CN109701161B - Method for stimulating cerebral motor cortex twitch - Google Patents
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Abstract
Embodiments of the present invention provide a method of stimulating cerebral motor cortex tics comprising: determining a first voltage value, wherein the stimulation intensity of a magnetic field generated by taking the voltage with the first voltage value as the input of a stimulation coil to the cerebral motor cortex reaches a motor threshold; determining a first frequency according to a first voltage value, wherein a pulse voltage with the first frequency and a first amplitude is used as a magnetic field generated by the input of a stimulation coil to stimulate the cerebral motor cortex, the stimulation intensity of the magnetic field on the cerebral motor cortex reaches a twitch threshold value, and the first amplitude is twice the first voltage value; and generating a driving voltage according to the first voltage value and the first frequency, inputting the driving voltage to the stimulation coil and continuously inputting the driving voltage for a first preset time period so that the magnetic field generated by the stimulation coil stimulates the cerebral motor cortex to twitch, wherein the driving voltage is a pulse voltage with the first frequency and a second amplitude, and the second amplitude is four times of the first voltage value. The method can screen out the effective stimulation scheme with minimum stimulation intensity in a short time to stimulate cerebral motor cortex twitches.
Description
Technical Field
The embodiment of the invention relates to the technical field of biological stimulation, in particular to a method for stimulating cerebral motor cortex twitches.
Background
MST (Magnetic seizure therapy) technology is a biostimulation technology developed in the middle of the 80 s of the 20 th century that affects and alters brain function. And with the development of technology, the application of the MST in clinical medicine is more and more paid attention to, MST is a biological stimulation technology which utilizes a time-varying magnetic field to act on the cerebral motor cortex to generate induced current to change action potential of cortical nerve cells, thereby affecting metabolism and nerve electric activity in the brain, and for some stimulation for changing brain functions, the cerebral motor cortex is required to generate convulsion.
At present, equipment (such as a transcranial magnetic stimulation instrument) based on the MST technology is in a test stage, and has the advantages of more stimulation parameters, more stimulation schemes, complex setting and difficult determination of ideal stimulation schemes for stimulating the tic attacks. The parameters which can be adjusted in the stimulation scheme are the stimulation intensity (expressed by 1-100% of the maximum output magnetic field intensity of the device), the stimulation intensity is adjusted by the voltage value input to the stimulation coil, the stimulation frequency is adjustable by 1-100Hz, the stimulation frequency is also adjustable by the frequency of the voltage input to the stimulation coil, the stimulation time is adjustable by 1-10 seconds, the stimulation time is also adjustable by the continuous input time of the voltage input to the stimulation coil, and 3 parameters are 100 choices and total 100 3 The individual arrangements can form 100 tens of thousands of stimulation schemes, so that it is difficult to select a reasonable scheme. The stimulation operation in the current MST technology is to gradually increase the stimulation dosage by using 0.1Hz low-frequency stimulation, stimulate once every 10 seconds, measure the movement threshold value (the minimum stimulation amount causing muscle contraction) of an individual, then empirically adjust the stimulation parameters by using ECT (Electric convulsive therapy), measure the tic threshold value (the minimum stimulation amount causing the tic) by using 100% output intensity, 100Hz frequency, gradually increase the time of a stimulation string every 20 seconds to determine the tic threshold value, multiply the threshold value by the stimulation amount of 2-4 times after determining the tic threshold value, and the whole operation process needs manual operation, which is particularly complicated and time-consuming. Since both the stimulus intensity and the stimulus frequency are 100%, merely changing the stimulus time often causes excessive stimulus and unnecessary side effects. And because of the difference of human brain anatomy structure, physiological and pathological state, coil stimulation position, nervous function change after convulsion, magnetic stimulation operation difference each time and other factors, MST is difficult to select a reasonable scheme suitable for individuation, and no general and fixed stimulation-induced convulsion mode exists at present. The reasonable twitch stimulation amount and stimulation method are difficult to select in the stimulation scheme, and the twitch and thorn cannot be caused by the too small stimulation amount by repeatedly selecting and adjusting various stimulation schemesThe over-excitation not only requires the equipment to output more power and increases the manufacturing difficulty of the equipment, but also can cause over-excitation and limb ache or potential brain cell injury.
The stimulation scheme of the MST technology comprises 3 conventional stimulation parameters of stimulation intensity, stimulation frequency and stimulation time, each parameter has 100 selectable values, and the selection of permutation and combination is varied. The stimulation scheme is even more countless if modes such as paired stimulation, burst stimulation, quadruple stimulation and the like which are increased in the recent years TMS (Transcranial magnetic stimulation) are added. Operators are often faced with numerous choices and it is difficult to screen for effective, minimal time, minimal stimulus-induced twitches in a short period of time.
Disclosure of Invention
To overcome or at least partially address the above problems, embodiments of the present invention provide a method of stimulating cerebral motor cortex twitches.
Embodiments of the present invention provide a method of stimulating cerebral motor cortex tics comprising: determining a first voltage value, wherein the voltage with the first voltage value is used as the input of a stimulation coil, so that the stimulation intensity of a magnetic field generated by the stimulation coil on the cerebral motor cortex reaches a motor threshold value, and the stimulation coil is arranged above the cerebral motor cortex; determining a first frequency according to a first voltage value, wherein a pulse voltage with the first frequency and a first amplitude is used as an input of a stimulation coil, so that the stimulation intensity of a magnetic field generated by the stimulation coil on the cerebral motor cortex reaches a twitch threshold value, and the first amplitude is twice the first voltage value; and generating a driving voltage according to the first voltage value and the first frequency, inputting the driving voltage to the stimulation coil and continuously inputting the driving voltage for a first preset time period so that the magnetic field generated by the stimulation coil stimulates the cerebral motor cortex to twitch, wherein the driving voltage is a pulse voltage with the first frequency and a second amplitude, and the second amplitude is four times that of the first voltage value.
Before the driving voltage is input to the stimulation coil and continuously input for a first preset time period, the method further comprises the following steps: and inputting a pulse voltage with the frequency of 50Hz and a third amplitude into the stimulation coil, so that the magnetic field generated by the stimulation coil prestimulates the cerebral motor cortex, wherein the third amplitude is a second voltage value, and the second voltage value does not exceed the first voltage value.
Wherein, after the driving voltage is input to the stimulation coil and continuously input for a first preset time period, the method further comprises: acquiring driving voltage and inputting the driving voltage to the stimulation coil so that a magnetic field generated by the stimulation coil stimulates a first blood pressure signal after the cerebral motor cortex; if the strength of the first blood pressure signal does not meet the preset condition, after the second preset time period, based on the continuous input time of the driving voltage input to the stimulation coil, gradually increasing the continuous input time of the driving voltage input to the stimulation coil by a first preset step length until the strength of the first blood pressure signal is determined to meet the preset condition or the continuous input time of the driving voltage reaches the continuous upper limit value, wherein the preset condition is that the duration of the strength of the first blood pressure signal exceeding the preset blood pressure strength threshold value is at least a third preset time period.
Wherein, based on the last input time of the driving voltage input to the stimulating coil, after gradually increasing the last input time of the driving voltage input to the stimulating coil by the first preset step, the method further comprises: if the continuous input time of the driving voltage reaches the continuous upper limit value and the intensity of the first blood pressure signal does not meet the preset condition, after a second preset time period, pulse voltage with second frequency and fourth amplitude is input to the stimulation coil and the continuous input time upper limit value is carried out, so that the magnetic field generated by the stimulation coil stimulates cerebral motor cortex twitches, the second frequency is the frequency upper limit value, and the fourth amplitude is the voltage upper limit value.
Wherein determining the first voltage value comprises: inputting first test pulse voltages with the frequency of 50Hz to the stimulation coils one by one, wherein each first test pulse voltage input to the stimulation coils lasts for 5 pulses, and the amplitude of the next first test pulse voltage is increased by a second preset step length based on the amplitude of the previous first test pulse voltage; after the first test pulse voltage is input to the stimulation coil each time, the first test pulse voltage is obtained and input to the stimulation coil, so that the magnetic field generated by the stimulation coil stimulates the composite electromyographic signals after the brain motor cortex until the maximum value of the composite electromyographic signals is determined to exceed a first preset value; and taking the amplitude of the corresponding first test pulse voltage when the maximum value of the composite electromyographic signal exceeds a first preset value as a first voltage value.
Wherein determining the first frequency based on the first voltage value comprises: inputting second test pulse voltages with first amplitudes to the stimulation coils one by one, wherein each second test pulse voltage input to the stimulation coils is continuously input for a fourth preset time period, and the frequency of the next second test pulse voltage is increased by a third preset step length based on the frequency of the previous second test pulse voltage; after the second test pulse voltage is input to the stimulation coil each time, the second test pulse voltage is acquired and input to the stimulation coil, so that the magnetic field generated by the stimulation coil stimulates the second blood pressure signal after the cerebral motor cortex until the maximum value of the second blood pressure signal is determined to exceed a second preset value; and taking the frequency of the second test pulse voltage corresponding to the maximum value of the second blood pressure signal exceeding the second preset value as the first frequency.
The embodiment of the invention provides a method for stimulating cerebral motor cortex twitch, which comprises the following steps: determining a first voltage value, wherein the voltage with the first voltage value is used as the input of a stimulation coil, so that the stimulation intensity of a magnetic field generated by the stimulation coil on the cerebral motor cortex reaches a motor threshold value, and the stimulation coil is arranged above the cerebral motor cortex; determining a first frequency according to a first voltage value, wherein a pulse voltage with the first frequency and a first amplitude is used as an input of a stimulation coil, so that the stimulation intensity of a magnetic field generated by the stimulation coil on the cerebral motor cortex reaches a twitch threshold value, and the first amplitude is twice the first voltage value; and generating a driving voltage according to the first voltage value and the first frequency, inputting the driving voltage to the stimulation coil and continuously inputting the driving voltage for a first preset time period so that the magnetic field generated by the stimulation coil stimulates the cerebral motor cortex to twitch, wherein the driving voltage is a pulse voltage with the first frequency and a second amplitude, and the second amplitude is four times that of the first voltage value. The method comprises the steps of determining a first voltage value according to a motion threshold, determining a first frequency according to a tic threshold, generating a driving voltage according to the first voltage value and the first frequency, driving a stimulation coil to generate a magnetic field through the driving voltage, and stimulating cerebral motor cortex tic, so that an effective stimulation scheme with minimum stimulation intensity is screened in a short time to stimulate cerebral motor cortex tic.
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In order to more clearly illustrate the embodiments of the present invention or the technical solutions of the prior art, the following description will briefly explain the drawings used in the embodiments or the description of the prior art, and it is obvious that the drawings in the following description are some embodiments of the present invention, and other drawings can be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 is a flow chart of a method of stimulating cerebral motor cortex tics according to an embodiment of the invention;
fig. 2 is a schematic diagram of a device for stimulating cerebral motor cortex twitches according to an embodiment of the present invention.
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention, and it is apparent that the described embodiments are some embodiments of the present invention, but not all embodiments of the present invention. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
An embodiment of the present invention provides a method of stimulating cerebral motor cortex tics, referring to fig. 1, comprising: s11, determining a first voltage value, wherein the voltage with the first voltage value is used as input of a stimulation coil, so that the stimulation intensity of a magnetic field generated by the stimulation coil on the cerebral motor cortex reaches a motor threshold value, and the stimulation coil is arranged above the cerebral motor cortex; s12, determining a first frequency according to a first voltage value, wherein a pulse voltage with the first frequency and a first amplitude is used as an input of a stimulation coil, so that the stimulation intensity of a magnetic field generated by the stimulation coil on the cerebral motor cortex reaches a twitch threshold value, and the first amplitude is twice the first voltage value; and S13, generating a driving voltage according to the first voltage value and the first frequency, inputting the driving voltage to the stimulation coil and continuously inputting the driving voltage for a first preset time period so that the magnetic field generated by the stimulation coil stimulates the cerebral motor cortex to twitch, wherein the driving voltage is a pulse voltage with the first frequency and a second amplitude, and the second amplitude is four times the first voltage value.
Specifically, devices based on MST technology, such as transcranial magnetic stimulation devices, mainly include an energy storage capacitor, a silicon controlled rectifier and a stimulation coil, wherein the energy storage capacitor can provide a constant voltage, the constant voltage is modulated into a pulse voltage by the silicon controlled rectifier and then is input into the stimulation coil, the stimulation coil generates a transient magnetic field with the same frequency as the pulse voltage under the action of the pulse voltage, the strength of the magnetic field is determined by the amplitude of the pulse voltage, and the duration of the magnetic field is determined by the duration of the voltage input into the stimulation coil, so that the stimulation strength (i.e., the magnetic field strength), the stimulation frequency (i.e., the frequency of the magnetic field) and the stimulation time (i.e., the duration of the magnetic field) in a stimulation scheme based on MST technology are respectively determined by the voltage value, the frequency and the duration of the voltage input into the stimulation coil, and the stimulation scheme is determined.
In order to screen out an effective stimulation scheme with minimum stimulation intensity in a short time, the embodiment firstly determines a first voltage value, wherein the voltage with the first voltage value is used as input of a stimulation coil, the stimulation intensity of a generated magnetic field to the cerebral motor cortex reaches a motor threshold, and the stimulation coil is arranged above the cerebral motor cortex to ensure that the magnetic field generated by the stimulation coil can generate effective stimulation to the cerebral motor cortex; the exercise threshold is the minimum stimulus intensity causing muscle contraction, and the first voltage value is determined based on the exercise threshold, so that the first voltage value can be ensured to be an optional minimum value; then determining a first frequency according to the first voltage value, wherein a pulse voltage with the first frequency and a first amplitude is used as an input of a stimulation coil, the stimulation intensity of the generated magnetic field to the cerebral motor cortex reaches a twitch threshold value, the first amplitude is twice the first voltage value, the twitch threshold value is the minimum stimulation intensity for leading twitch, and the first frequency determined based on the twitch threshold value can ensure that the first frequency is an optional minimum value; finally, generating a driving voltage according to the first voltage value and the first frequency, wherein the driving voltage is a pulse voltage with the first frequency and the second amplitude, inputting the driving voltage to the stimulation coil and continuously inputting the driving voltage for a first preset time period so that the magnetic field generated by the stimulation coil stimulates the cerebral motor cortex to twitch, the amplitude of the driving voltage is a multiple of the first voltage value, the continuous input time of the driving voltage can be determined according to historical experience, the second amplitude in the embodiment is four times of the first voltage value, and the first preset time period can be six seconds; the first voltage value may be converted to a percentage of the maximum storage voltage of the storage capacitor, for example, the first voltage value may be converted to a percentage of the maximum storage voltage of the storage capacitor of 20%, and the amplitude of the driving voltage may be 80% of the maximum storage voltage of the storage capacitor. The driving voltage is generated through the first voltage value and the first frequency, so that the lower limit value of the amplitude and the frequency of the driving voltage is ensured to be rapidly determined, the effective stimulation scheme with the minimum stimulation intensity is further ensured to be screened out in a short time to stimulate cerebral motor cortex twitches, and side effects caused by overlarge stimulation intensity are avoided.
The driving voltage can be generated through a device shown in fig. 2 and input into a stimulation coil to finish stimulation of the brain motor cortex, wherein a switch 1 controls whether a singlechip is started, a singlechip 2 controls the charge amount of an energy storage capacitor 3 and the switching frequency of a controllable silicon 4, the voltage of the energy storage capacitor 3 is input into the controllable silicon 4 and is modulated into pulse voltage with the same frequency as the switching frequency of the controllable silicon 4 through the controllable silicon 4, the generated pulse voltage is the driving voltage, the driving voltage is input into a stimulation coil 5 positioned above the human brain 6, and the generated magnetic field realizes stimulation of the brain motor cortex.
According to the method for stimulating cerebral motor cortex twitches, a first voltage value is determined according to a motor threshold, a first frequency is determined according to a twitch threshold, a driving voltage is generated according to the first voltage value and the first frequency, a stimulation coil is driven by the driving voltage to generate a magnetic field, and cerebral motor cortex twitches are stimulated, so that an effective stimulation scheme with minimum stimulation intensity is screened in a short time to stimulate cerebral motor cortex twitches.
Based on the above embodiment, before the driving voltage is input to the stimulation coil and continuously input for the first preset period of time, the method further includes: and inputting a pulse voltage with the frequency of 50Hz and a third amplitude into the stimulation coil, so that the magnetic field generated by the stimulation coil prestimulates the cerebral motor cortex, wherein the third amplitude is a second voltage value, and the second voltage value does not exceed the first voltage value.
Specifically, before the driving voltage is used for driving the stimulation coil to generate a magnetic field to stimulate the cerebral motor cortex, the cerebral motor cortex is also prestimulated by a magnetic field with relatively weak stimulation intensity, and the prestimulation can improve the excitability of the cerebral motor cortex so as to reduce the tic threshold, so that the tic of the cerebral motor cortex can be realized more easily by a low-intensity pulse magnetic field; the magnetic field for pre-stimulating the cerebral motor cortex can be generated by driving the stimulating coil through pulse voltage with the frequency of 50Hz and third amplitude, and continuously driving 5 pulses, wherein the third amplitude is a second voltage value, and the second voltage value does not exceed the first voltage value.
Based on the above embodiment, after the driving voltage is input to the stimulation coil and continuously input for the first preset period of time, the method further includes: acquiring driving voltage and inputting the driving voltage to the stimulation coil so that a magnetic field generated by the stimulation coil stimulates a first blood pressure signal after the cerebral motor cortex; if the strength of the first blood pressure signal does not meet the preset condition, after the second preset time period, based on the continuous input time of the driving voltage input to the stimulation coil, gradually increasing the continuous input time of the driving voltage input to the stimulation coil by a first preset step length until the strength of the first blood pressure signal is determined to meet the preset condition or the continuous input time of the driving voltage reaches the continuous upper limit value, wherein the preset condition is that the duration of the strength of the first blood pressure signal exceeding the preset blood pressure strength threshold value is at least a third preset time period.
Specifically, as to whether or not the cerebral motor cortex produces a tic, it may be determined by a blood pressure signal, which may be obtained by a cuff pressure signal received by a sphygmomanometer, and a determination condition for determining whether the cerebral motor cortex produces a tic may be set as the following preset condition: the duration that the intensity of the first blood pressure signal exceeds the preset blood pressure intensity threshold is at least a third preset duration, wherein the first blood pressure signal is a blood pressure signal measured by a sphygmomanometer after the driving voltage is input to a magnetic field generated by the stimulation coil to stimulate the cerebral motor cortex, the blood pressure intensity threshold can be determined according to historical data, and the third preset duration can be set to 10 seconds.
If the intensity of the first blood pressure signal after the driving voltage is input to the magnetic field generated by the stimulation coil to stimulate the cerebral motor cortex does not meet the preset condition, it is indicated that the cerebral motor cortex has not been twitched, the second preset time period may be set to 20 seconds after the second preset time period, the input time of the driving voltage to the stimulation coil is increased to maintain the longer magnetic field to stimulate the cerebral motor cortex, the increased input time is gradually increased by a first preset step length based on the continuous input time of the driving voltage previously input to the stimulation coil, so as to gradually increase the stimulation intensity to the cerebral motor cortex, the first preset step length may be set to 1 second until it is determined that the intensity of the first blood pressure signal meets the preset condition or the continuous input time of the driving voltage reaches the continuous upper limit value, wherein the continuous upper limit value is 10 seconds, and the continuous upper limit value is used for avoiding the stimulation to the overlong time of the cerebral motor cortex and avoiding the bad influence to the human body.
The above process may also be implemented by a device as shown in fig. 2, where the second preset duration and the first preset step length may be implemented by controlling the thyristor 4 by the singlechip 2, the first blood pressure signal may be obtained by a sphygmomanometer in the detecting instrument 7, and the auxiliary detection may be performed by an electroencephalograph and an electromyograph in the detecting instrument 7, and the parameters of various stimulus signals and detection signals such as blood pressure signals may be displayed by the display screen 8.
Based on the above embodiment, after gradually increasing the duration of the driving voltage input to the stimulation coil by the first preset step based on the duration of the driving voltage input to the stimulation coil, the method further includes: if the continuous input time of the driving voltage reaches the continuous upper limit value and the intensity of the first blood pressure signal does not meet the preset condition, after a second preset time period, pulse voltage with second frequency and fourth amplitude is input to the stimulation coil and the continuous input time upper limit value is carried out, so that the magnetic field generated by the stimulation coil stimulates cerebral motor cortex twitches, the second frequency is the frequency upper limit value, and the fourth amplitude is the voltage upper limit value.
Specifically, if the continuous input time of the driving voltage reaches the upper limit value of the continuous time, the cerebral motor cortex is not twitched yet, the maximum output value of the equipment used in the human body bearing is ensured, and the cerebral motor cortex is twitched, wherein the upper limit value of the frequency is 100Hz, the upper limit value of the voltage is the maximum output voltage of the energy storage capacitor, and the upper limit value of the continuous time of the driving voltage input to the stimulation coil is 10 seconds.
Based on the above embodiments, determining the first voltage value includes: inputting first test pulse voltages with the frequency of 50Hz to the stimulation coils one by one, wherein each first test pulse voltage input to the stimulation coils lasts for 5 pulses, and the amplitude of the next first test pulse voltage is increased by a second preset step length based on the amplitude of the previous first test pulse voltage; after the first test pulse voltage is input to the stimulation coil each time, the first test pulse voltage is obtained and input to the stimulation coil, so that the magnetic field generated by the stimulation coil stimulates the composite electromyographic signals after the brain motor cortex until the maximum value of the composite electromyographic signals is determined to exceed a first preset value; and taking the amplitude of the corresponding first test pulse voltage when the maximum value of the composite electromyographic signal exceeds a first preset value as a first voltage value.
Specifically, the first voltage value is determined by a first test pulse voltage which is input to the stimulating coil one by one, wherein the frequency of the first test pulse voltage is 50Hz, 5 pulses are continued, the amplitude of the following first test pulse voltage is increased by a second preset step length based on the amplitude of the preceding first test pulse voltage, the second preset step length can be calculated according to the percentage of the maximum output voltage of the energy storage capacitor, the amplitude of the first test pulse voltage which is input to the stimulating coil is 20% of the maximum output voltage of the energy storage capacitor, after the first test pulse voltage is input to the stimulating coil, a composite electromyography signal after the brain motion cortex is stimulated by a magnetic field generated by the first test pulse voltage is acquired, the composite electromyography signal can be measured by an electromyography in a detection instrument 7 in fig. 2, if the maximum value of the composite electromyography signal does not exceed the first preset value, the first preset step length can be set to 50uV, the stimulation strength of the magnetic field generated by the first test pulse voltage after the first test pulse voltage is input to the stimulating coil does not reach the motion threshold value, the first electrical signal according to the second preset step length can be increased by the first preset step length, and the maximum value can be set to the maximum value when the maximum value of the maximum output voltage exceeds the first preset value, and the maximum value of the composite electromyography voltage exceeds the first preset value, and the composite electromyography signal can be measured by the maximum value.
Based on the above embodiments, determining the first frequency from the first voltage value includes: inputting second test pulse voltages with first amplitudes to the stimulation coils one by one, wherein each second test pulse voltage input to the stimulation coils is continuously input for a fourth preset time period, and the frequency of the next second test pulse voltage is increased by a third preset step length based on the frequency of the previous second test pulse voltage; after the second test pulse voltage is input to the stimulation coil each time, the second test pulse voltage is acquired and input to the stimulation coil, so that the magnetic field generated by the stimulation coil stimulates the second blood pressure signal after the cerebral motor cortex until the maximum value of the second blood pressure signal is determined to exceed a second preset value; and taking the frequency of the second test pulse voltage corresponding to the maximum value of the second blood pressure signal exceeding the second preset value as the first frequency.
Specifically, a second test pulse voltage with a first amplitude is input to the stimulation coils one by one, the first amplitude is twice the first voltage value, each second test pulse voltage input to the stimulation coils is continuously input for a fourth preset time period, the second test pulse voltage can be generated by the device shown in fig. 2, wherein the fourth preset time period can be set to 6 seconds, the frequency of the latter second test pulse voltage is increased by a third preset step length based on the frequency of the former second test pulse voltage, the frequency of the first second test pulse voltage is 20Hz, and the third preset step length can be set to 10Hz; after each time the second test pulse voltage is input to the stimulation coil, obtaining a second blood pressure signal after the magnetic field generated by the second test pulse voltage input to the stimulation coil stimulates the cerebral motor cortex, wherein the second blood pressure signal can be measured by a sphygmomanometer 7 in the detecting instrument shown in fig. 2 until it is determined that the maximum value of the second blood pressure signal exceeds a second preset value, wherein the second preset value can be determined according to historical data; and taking the frequency of the second test pulse voltage corresponding to the maximum value of the second blood pressure signal exceeding the second preset value as the first frequency.
The last explanation is: the above embodiments are only for illustrating the technical solution of the present invention, and are not limiting; although the invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit and scope of the technical solutions of the embodiments of the present invention.
Claims (4)
1. A device for stimulating motor cortex twitches in the brain, comprising: the single chip microcomputer is connected with the energy storage capacitor and the silicon controlled rectifier respectively;
the singlechip is used for determining a first voltage value, wherein the voltage with the first voltage value is used as the input of a stimulation coil, so that the stimulation intensity of a magnetic field generated by the stimulation coil on the cerebral motor cortex reaches a motion threshold value, and the stimulation coil is arranged above the cerebral motor cortex;
the singlechip is further configured to determine a first frequency according to the first voltage value, where the silicon controlled rectifier is configured to modulate a voltage output by the energy storage capacitor into a pulse voltage with the first frequency and a first amplitude, and use the pulse voltage as an input of the stimulation coil, so that a stimulation intensity of a magnetic field generated by the stimulation coil on a cerebral motor cortex reaches a twitch threshold, and the first amplitude is twice the first voltage value;
the controllable silicon is used for modulating the voltage output by the energy storage capacitor so as to output a driving voltage, wherein the driving voltage is input to the stimulating coil and continuously input for a first preset time period so that the magnetic field generated by the stimulating coil stimulates the cerebral motor cortex to twitch, the driving voltage is a pulse voltage with the first frequency and the second amplitude, and the second amplitude is four times the first voltage value;
the device further comprises a detection instrument; the input of the stimulation coil further comprises first test pulse voltages with the frequency of 50Hz which are input one by one, each first test pulse voltage input to the stimulation coil lasts for 5 pulses, and the amplitude of the subsequent first test pulse voltage is increased by a second preset step length based on the amplitude of the previous first test pulse voltage;
the detection instrument is used for acquiring a first test pulse voltage and inputting the first test pulse voltage to the stimulation coil after inputting the first test pulse voltage to the stimulation coil each time, so that a magnetic field generated by the stimulation coil stimulates a composite electromyographic signal after brain motor cortex until the maximum value of the composite electromyographic signal is determined to exceed a first preset value;
the first voltage value is the amplitude of the first test pulse voltage corresponding to the maximum value of the composite electromyographic signal exceeding the first preset value;
the input of the stimulation coil further comprises second test pulse voltages with the first amplitude, wherein the second test pulse voltages are input one by one, each second test pulse voltage input to the stimulation coil is continuously input for a fourth preset duration, and the frequency of the latter second test pulse voltage is increased by a third preset step length based on the frequency of the former second test pulse voltage;
the detecting instrument is further configured to obtain, after each time of inputting a second test pulse voltage to the stimulation coil, a second blood pressure signal obtained after the stimulation coil generates a magnetic field to stimulate the cerebral motor cortex, until it is determined that a maximum value of the second blood pressure signal exceeds a second preset value;
the first frequency is the frequency of the second test pulse voltage corresponding to the case that the maximum value of the second blood pressure signal exceeds the second preset value.
2. The apparatus of claim 1, wherein the input voltage to the stimulation coil further comprises a continuous 5 pulse voltage such that the magnetic field generated by the stimulation coil pre-stimulates the cerebral motor cortex, wherein the continuous 5 pulse voltage is a pulse voltage having a frequency of 50Hz and a voltage value of a third amplitude, the third amplitude being a second voltage value, the second voltage value not exceeding the first voltage value.
3. The apparatus of claim 1, wherein the detection instrument is further configured to obtain a first blood pressure signal after the driving voltage is input to the stimulation coil, so that the magnetic field generated by the stimulation coil stimulates the motor cortex of the brain;
the singlechip is further configured to, after determining that the intensity of the first blood pressure signal does not meet a preset condition, control the silicon controlled rectifier to gradually increase the duration of input of the driving voltage to the stimulation coil by a first preset step length based on the duration of input of the driving voltage to the stimulation coil after a second preset time length until it is determined that the intensity of the first blood pressure signal meets the preset condition or the duration of input of the driving voltage reaches a duration upper limit value, where the preset condition is that the duration of the intensity of the first blood pressure signal exceeding a preset blood pressure intensity threshold is at least a third preset time length.
4. The apparatus of claim 3, wherein the input of the stimulation coil further comprises a pulse voltage having a second frequency and a fourth amplitude, the pulse voltage being input after determining that a duration of the input of the driving voltage reaches an upper duration limit and that the intensity of the first blood pressure signal does not meet the preset condition, and after a second preset duration, the pulse voltage being continuously input to the upper duration limit such that the magnetic field generated by the stimulation coil stimulates the cerebral motor cortex twitches, the second frequency being an upper frequency limit and the fourth amplitude being an upper voltage limit.
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