CN109675202A - A kind of smooth power and ultrasonic atomizatio combination therapy device and treatment method - Google Patents
A kind of smooth power and ultrasonic atomizatio combination therapy device and treatment method Download PDFInfo
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- CN109675202A CN109675202A CN201811568424.2A CN201811568424A CN109675202A CN 109675202 A CN109675202 A CN 109675202A CN 201811568424 A CN201811568424 A CN 201811568424A CN 109675202 A CN109675202 A CN 109675202A
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/005—Sprayers or atomisers specially adapted for therapeutic purposes using ultrasonics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/05—General characteristics of the apparatus combined with other kinds of therapy
- A61M2205/051—General characteristics of the apparatus combined with other kinds of therapy with radiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
- A61N2005/0642—Irradiating part of the body at a certain distance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/065—Light sources therefor
- A61N2005/0651—Diodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0664—Details
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Radiation-Therapy Devices (AREA)
Abstract
The present invention provides a kind of smooth power and ultrasonic atomizatio combination therapy device and treatment method, the device includes: host, corresponding light source control signal is exported for determining treatment time and irradiation distance, and according to preset light sequence irradiation mode, is also used to prepare the mist particle water containing oxygen；Irradiator generates the exposure light for meeting light sequence irradiation mode, and be irradiated under irradiation distance according to treatment region of the treatment time to patient for receiving light source control signal；Atomized spray mechanism, for receiving and spraying mist particle water to the treatment region of patient.The Uniform Irradiation to the treatment region of patient can be achieved in the present invention, personalized therapeutic scheme targetedly can be realized to different patient and its different treatment region, mist particle water can also be sprayed to the treatment region of patient, it effectively prevent the enzymatic reaction speed of the precursor of photosensitizer substance to decline, to improve optical dynamic therapy effect.
Description
Technical field
The present invention relates to field of photodynamic, and in particular to a kind of smooth power and ultrasonic atomizatio combination therapy device and controls
Treatment method.
Background technique
In recent years, optical dynamic therapy (PDT) is widely answered in the indications such as treatment skin diseases, medical cosmetology
With.However, there are some problems for optical power therapentic equipment in the prior art, it is each different wave length in radiation source first
The light angle of scattering of LED chip is different, so that illumination power density distribution of the different wavelengths of light in patient treatment region
Curve form is widely different, the efficiency of light energy utilization is low, uneven illumination is even, to cause using multiple and different wavelength LED as light source
The multispectral combination therapy of light power it is ineffective；Secondly, in association illumination parameter, the upper primary limitation of light irradiation strategy in illumination
Power density, optical source wavelength, treatment time etc., regulating power is limited, cannot give full play to the excellent of multispectral optical dynamic therapy
Gesture is unsuitable for realizing personalized therapeutic scheme.
In addition, during optical dynamic therapy, the precursor of the skin for the treatment of region in photosensitizer or photosensitizer substance
Under effect is lower and the irradiation of exposure light, the precursor of skin and photosensitizer or photosensitizer substance can all generate a degree of de-
Water, simultaneously because the irradiation of exposure light is so that the raising of skin surface local temperature, causes the senses of discomfort such as dry skin, scorching hot.And
And the precursor of the widely used photosensitizer substance of partial clinical, itself does not have light sensitivity, it is closed by enzymatic reaction
Adult body endogenous photosensitizers protoporphyrin PpIX substance and play photosensitization, to will cause its enzymatic anti-for the factors such as heating, dehydration
Speed is answered to decline, so that the endogenous photosensitizers quantity decline of synthesis, to influence the effect and application of optical dynamic therapy.
Summary of the invention
The embodiment of the present invention provides a kind of smooth power and ultrasonic atomizatio combination therapy device and treatment method, existing to solve
The radiation response of radiation source is bad in optical power therapentic equipment in technology, is unsuitable for realizing personalized therapeutic scheme, and
Optical dynamic therapy process easily make treatment region skin surface local temperature increase and drying and dehydrating and make therapeutic effect not
Good problem.
In a first aspect, the embodiment of the present invention provides a kind of smooth power and ultrasonic atomizatio combination therapy device, described device packet
It includes:
Host for determining treatment time and irradiation distance according to preset illumination parameter, and sorts according to preset light
Irradiation mode exports corresponding light source control signal；It is also used to prepare the mist particle water containing oxygen；
Irradiator is connect with the host, and for receiving the light source control signal, generation meets the light sequence spoke
According to the parallel collimation and the uniform exposure light of hot spot of at least one different peak wavelengths of mode, and pressed under the irradiation distance
It is irradiated according to treatment region of the treatment time to patient；
Atomized spray mechanism is connect with the host, for receiving the mist particle water, and to patient
Treatment region sprays the mist particle water.
As the preferred embodiment of first aspect present invention, the irradiator includes irradiator end cap and is arranged in the spoke
According to the radiation source below device end cap；
The radiation source includes successively multispectral irradiation mould group, the first optical lens array and the second light disposed in parallel
Learn lens array；The multispectral irradiation mould group includes wiring board and at least one can generate the parallel of different peak wavelengths
The multispectral Sony ericsson mobile comm ab of collimation and the uniform light beam of hot spot, each multispectral orthogonal thereto array row of Sony ericsson mobile comm ab
Cloth is on the wiring board；There is the refractive lenslet of multiple orthogonal thereto array arrangements on first optical lens array
Side is towards the multispectral irradiation mould group, with the refraction of multiple orthogonal thereto array arrangements on second optical lens array
Each lenslet of the side of type lenslet in the multispectral irradiation mould group, second optical lens array and described the
The center of each lenslet on one optical lens array is overlapped and each side corresponds；The multispectral irradiation mould group and described the
The distance of one optical lens array is 3~5mm, and first optical lens array is at a distance from second optical lens array
It is 0.85~1.15 times of the focal length of the lenslet.
As the preferred embodiment of first aspect present invention, the multispectral Sony ericsson mobile comm ab includes package substrate, described
It is provided with reflector on the loading end of package substrate, at least two different peak value waves are provided in the accommodation space of the reflector
Long solid-state light emitting element；The package substrate two sides are provided at least two pairs of electrodes, the electrode and solid luminescent member
The positive and negative anodes of part are connected, and the electrode is also connect with the host；Also closed off at the light-emitting window of the reflector be provided with it is micro-
Lens array, the microlens array is parallel with the package substrate, and has multiple orthogonal thereto arrays on the microlens array
The side of the refractive hemispherical microlenses of arrangement is backwards to the solid-state light emitting element.
As the preferred embodiment of first aspect present invention, the radius of the lenticule is 0.05~0.25mm, described micro-
The focal length of mirror is 0.8mm, and the distance between rounded bottom surface of the adjacent lenticule is 0mm.
As the preferred embodiment of first aspect present invention, the host includes man-machine interaction unit, Decision Control unit, light
Source driving unit and atomization generating unit, the man-machine interaction unit, the light source driving units and the atomization generating unit
Connect respectively with the Decision Control unit, the Decision Control unit and the atomization generating unit also respectively with the atomization
Injection equipment connection.
As the preferred embodiment of first aspect present invention, the atomization generating unit include ultrasonic atomizatio room, liquid container,
Air supplying part, heating part, oxygen portion processed, solenoid valve, ozone generating unit and output interface, the liquid container and air supplying part difference
It is set to above and below the ultrasonic atomizatio room, the ultrasonic atomizatio room is connect by pipeline with the heating part, described
Oxygen portion processed connect with the solenoid valve by pipeline, the heating part and the solenoid valve pass through respectively pipeline through three-way connection and
The output interface connection, the output interface are also connect with the atomized spray mechanism；The ozone generating unit is arranged in institute
Solenoid valve is stated to connect on the pipeline of the three-way connection.
As the preferred embodiment of first aspect present invention, the atomized spray mechanism includes injection spray pipe, water collector and miniature
Water pump, the side of the injection spray pipe are provided with into water and connect mouth, and the side of the water collector is provided with draining and connects mouth, the Miniature water
Pump connects mouth with the water inlet by drainpipe respectively and the draining connects mouth and connect；The water collector is set in the injection spray pipe
On lower end, the water collector includes lower cover and upper end cover, is provided on the lower cover to the upper end cover direction and is extended
Horn-like boss, the periphery of the boss is provided with multiple U-type grooves, so that the condensed water on the spraying inside pipe wall passes through institute
U-type groove is stated to enter in the water collector.
Second aspect, the embodiment of the present invention provide a kind of smooth power and ultrasonic atomizatio combination therapy method, the method packet
It includes:
Host determines treatment time and irradiation distance, and sort and irradiate according to the light of input according to the illumination parameter of input
Mode exports corresponding light source control signal, arranges so that the irradiator meets the light according to light source control signal generation
Sequence irradiates the parallel collimation and the uniform exposure light of hot spot of at least one different peak wavelengths of mode, and in the irradiation distance
Under be irradiated according to treatment region of the treatment time to patient；The illumination parameter includes at least one exposure light
Peak wavelength and the exposure light to match with the treatment region of patient light energy density and illumination power
Density；
The host prepares and exports the mist particle water containing oxygen, so that atomized spray mechanism is in the irradiator
During being irradiated to the treatment region of patient, the mist water is sprayed to the treatment region of patient
Grain.
As the preferred embodiment of second aspect of the present invention, the light sequence irradiation mode includes the first light sequence irradiation mould
Formula, the second light sequence irradiation mode and third light sequence irradiation mode；
The first light sequence irradiation mode is that a kind of exposure light of peak wavelength carries out the treatment region of patient
Duplicate continuous or segmentation irradiation, until stopping when reaching its preset light energy density；
The second light sequence irradiation mode is the exposure light of at least two different peak wavelengths simultaneously to patient
Treatment region carries out duplicate continuous or segmentation irradiation, stops when one of exposure light reaches its preset light energy density
It only irradiates, remaining exposure light continues to be irradiated the treatment region of patient, presets until all exposure lights reach it
Light energy density when stop irradiation；
The third light sequence irradiation mode is the exposure light cycle alternation of at least two different peak wavelengths to treated
The treatment region of person carries out duplicate continuous or segmentation irradiation, when one of exposure light reaches its preset light energy density
When stop irradiation, remaining exposure light continues to be irradiated the treatment region of patient, until all exposure lights reach it
Stop irradiation when preset light energy density.
As the preferred embodiment of second aspect of the present invention, the step of determining irradiation distance according to the illumination parameter, includes:
Establish distance-illumination saturation effect database of the exposure light, the distance-illumination saturation effect
Database is used to indicate the exposure light and illumination power density average value of the target target surface under different distance；
Based on the distance-illumination saturation effect database, using linear interpolation method according to the illumination parameter
Described in the illumination power density of exposure light determine the irradiation distance.
A kind of smooth power provided in an embodiment of the present invention and ultrasonic atomizatio combination therapy device and treatment method, pass through host
According to treatment time and the irradiation distance for determining the patient for the preset illumination parameter of specific patient, and according to pre-
If light sequence irradiation mode export corresponding light source control signal, so that generating irradiator meets light sequence irradiation mode
The parallel collimation and the uniform exposure light of hot spot of at least one difference peak wavelength, and in the treatment region of irradiator and patient
The distance between domain is maintained under irradiation distance, is shone according to the treatment time determined to the treatment region of patient
It penetrates.Therefore, the Uniform Irradiation to the treatment region of patient can be achieved in the present invention, and exposure light is in the treatment region of patient
Illumination power density distribution curved surface height in domain is similar, and the efficiency of light energy utilization is high, can effectively enhance therapeutic effect；Meanwhile energy
It is enough targetedly to different patient and its different treatment region according to different irradiation distances, different treatment times and not
The irradiation mode etc. that sorts of sharing the same light is irradiated, and is realized personalized therapeutic scheme, can be obtained preferable therapeutic effect.
In addition, also the mist particle water containing oxygen is prepared by host, in treatment of the irradiator to patient
During region is irradiated, mist particle water is sprayed to the treatment region of patient, is drawn with mitigating in therapeutic process
The local temperature risen increases, has dry skin the senses of discomfort such as scorching hot, effectively prevent the enzymatic reaction speed of the precursor of photosensitizer substance
While degree decline, the yield of singlet oxygen during photodynamic reaction is not had an impact, light power is can further improve and controls
Therapeutic effect.
Detailed description of the invention
To describe the technical solutions in the embodiments of the present invention more clearly, make required in being described below to embodiment
Attached drawing is briefly described, it should be apparent that, drawings in the following description are only some embodiments of the invention, for
For those of ordinary skill in the art, without creative efforts, it can also be obtained according to these attached drawings other
Attached drawing.
Fig. 1 is a kind of structural block diagram of smooth power and ultrasonic atomizatio combination therapy device provided in an embodiment of the present invention；
Fig. 2 is a kind of decomposition of irradiator in smooth power and ultrasonic atomizatio combination therapy device provided in an embodiment of the present invention
Structural schematic diagram；
Fig. 3 is a kind of irradiation of irradiator in smooth power and ultrasonic atomizatio combination therapy device provided in an embodiment of the present invention
The structural schematic diagram of light source；
Fig. 4 is a kind of irradiation of irradiator in smooth power and ultrasonic atomizatio combination therapy device provided in an embodiment of the present invention
The structural schematic diagram of multispectral irradiation mould group in light source；
Fig. 5 is a kind of irradiation of irradiator in smooth power and ultrasonic atomizatio combination therapy device provided in an embodiment of the present invention
The structural schematic diagram for the multispectral Sony ericsson mobile comm ab that multispectral irradiation mould group in light source uses；
Fig. 6 is a kind of smooth power provided in an embodiment of the present invention and irradiator in ultrasonic atomizatio combination therapy device and existing
The radiation response comparison diagram of irradiator in technology；
Fig. 7 is atomized spray process in a kind of smooth power and ultrasonic atomizatio combination therapy device provided in an embodiment of the present invention
Specific implementation structural block diagram；
Fig. 8 is atomized spray mechanism in a kind of smooth power and ultrasonic atomizatio combination therapy device provided in an embodiment of the present invention
Decomposition texture schematic diagram；
Fig. 9 is that the specific structure of a kind of smooth power and ultrasonic atomizatio combination therapy device provided in an embodiment of the present invention is illustrated
Figure；
Figure 10 is a kind of flow diagram of smooth power and ultrasonic atomizatio combination therapy method provided in an embodiment of the present invention；
Figure 11 is to arrange in a kind of smooth power provided in an embodiment of the present invention and ultrasonic atomizatio combination therapy method in the first light
A kind of exposure light of peak wavelength is in the control signal schematic representation that lighting with extinguishing being segmented under radiation mode under sequence irradiation mode；
Figure 12 is to arrange in a kind of smooth power provided in an embodiment of the present invention and ultrasonic atomizatio combination therapy method in the second light
The exposure light of at least two different peak wavelengths is believed in the control lighted with extinguished being segmented under radiation mode under sequence irradiation mode
Number schematic diagram；
Figure 13 is to arrange in a kind of smooth power provided in an embodiment of the present invention and ultrasonic atomizatio combination therapy method in third light
The exposure light of at least two different peak wavelengths is believed in the control lighted with extinguished being segmented under radiation mode under sequence irradiation mode
Number schematic diagram.
Wherein, 201, irradiator end cap, 202, multispectral irradiation mould group, 202-1, wiring board, 202-2, multispectral solid-state
Luminescent device, the 203, first optical lens array, the 204, second optical lens array, 205, radiator fan, 206, injection spray pipe,
206-1, water inlet connect mouth, 207, water collector, and 207-1, draining connect mouth, 207-2, upper end cover, 207-3, lower cover, 207-4, convex
Platform, 208, micro pump, 209, sealing ring, 210, nut, 211, through-hole, 212, aperture；
501, package substrate, 502, reflector, 503, solid-state light emitting element, 504, electrode, 505, microlens array；
901, host, 902, irradiator, 903, automatic resistance stop multi-joint suspension arm, 9031, upper arm parts, 9032, lower arm part,
9033, wrist, 9034, terminal connection portion, 9035, band annulus D type shield irdome, 904, support portion, 905, liquid crystal display, 906,
IC card seat, 907, knob, 908, universal caster wheel.
Specific embodiment
In order to enable those skilled in the art to better understand the solution of the present invention, below in conjunction in the embodiment of the present invention
Attached drawing, technical scheme in the embodiment of the invention is clearly and completely described, it is clear that described embodiment is only
The embodiment of a part of the invention, instead of all the embodiments.Based on the embodiments of the present invention, ordinary skill people
The model that the present invention protects all should belong in member's every other embodiment obtained without making creative work
It encloses.
It should also be noted that similar label and letter indicate similar terms in following attached drawing, therefore, once a certain Xiang Yi
It is defined in a attached drawing, does not then need that it is further defined and explained in subsequent attached drawing.
Since the treatment region of different patient is different with the depth position of diseased region in vivo, while not
Also there is larger difference with the photosensitizer that patient uses, so that different patient are when receiving optical dynamic therapy, such as
Fruit targetedly can not realize personalized therapeutic scheme to different patient and its different treatment region, i.e., different
Patient according to different irradiation distances, different treatment times and different peak wavelength light light sequence irradiation mode etc.
It is irradiated, is then difficult to obtain preferable therapeutic effect.
Simultaneously as human body different tissues have differences the absorptivity and scattered power of photon, so that different peak wavelengths
Light different penetration depthes is woven with to group, and the photosensitizer used in actual optical dynamic therapy is commonly present multiple absorption light
Therefore spectrum peak selects the light of multiple peak wavelengths to carry out joint irradiation in optical dynamic therapy, acquired therapeutic effect is logical
It is often better than the therapeutic effect of the light using single peak value wavelength.In addition, if generating each difference in the radiation source of exposure light
The light angle of scattering of the LED chip of peak wavelength is different, can make different peak wavelength light in the treatment region of patient
Illumination power density distribution curve form it is widely different, lead to that the efficiency of light energy utilization is low, uneven illumination is even, to cause with multiple
Different peak wavelength LED as light source the multispectral combination therapy of light power it is ineffective.
In addition, during optical dynamic therapy, the precursor of the skin for the treatment of region in photosensitizer or photosensitizer substance
Under effect is lower and the irradiation of exposure light, the precursor of skin and photosensitizer or photosensitizer substance can all generate a degree of de-
Water, simultaneously because the irradiation of exposure light is so that the raising of skin surface local temperature, causes the senses of discomfort such as dry skin, scorching hot.And
And the precursor of the widely used photosensitizer substance of partial clinical, itself does not have light sensitivity, it is closed by enzymatic reaction
Adult body endogenous photosensitizers protoporphyrin PpIX substance and play photosensitization, to will cause its enzymatic anti-for the factors such as heating, dehydration
Speed is answered to decline, so that the endogenous photosensitizers quantity decline of synthesis, to influence the effect and application of optical dynamic therapy.
The embodiment of the invention discloses a kind of smooth power and ultrasonic atomizatio combination therapy device, shown referring to Fig.1, the device
It specifically includes that
Host for determining treatment time and irradiation distance according to preset illumination parameter, and sorts according to preset light
Irradiation mode exports corresponding light source control signal；It is also used to prepare the mist particle water containing oxygen；
Irradiator is connect with host, and for receiving light source control signal, generation meets light sequence irradiation mode at least
A kind of the parallel of difference peak wavelength collimates and the uniform exposure light of hot spot, and under irradiation distance according to treatment time to being controlled
The treatment region for the treatment of person is irradiated；
Atomized spray mechanism, connect with host, for receiving mist particle water, and to the treatment region of patient
Spray mist particle water.
In the present embodiment, it is respectively provided with host and irradiator, then by host according to pre- for specific patient
If illumination parameter determine treatment time and the irradiation distance of the patient, and according to being directed to the preset light of specific patient
The irradiation mode that sorts exports corresponding light source control signal to irradiator；Irradiator generation meets light sequence irradiation mode at least
It is a kind of difference peak wavelength it is parallel collimate and the uniform exposure light of hot spot, and the treatment region of irradiator and patient it
Between distance when being maintained at irradiation distance, be irradiated according to the treatment time determined to the treatment region of patient.It is main
Machine can also prepare the mist particle water containing oxygen.
Therefore, the Uniform Irradiation to the treatment region of patient is realized, and exposure light is in the treatment of patient
Illumination power density distribution curved surface height in region is similar, and the efficiency of light energy utilization is high, can effectively enhance therapeutic effect；Meanwhile
Can targetedly to different patient and its different treatment region according to different irradiation distances, different treatment times and
The irradiation mode etc. that sorts of not sharing the same light is irradiated, and is realized personalized therapeutic scheme, can be obtained preferable therapeutic effect.
Meanwhile it being also provided with atomized spray mechanism, the aerosol containing oxygen of atomized spray authorities host output
Shape particle water sprays during treatment region of the irradiator to patient is irradiated to the treatment region of patient
The mist particle water is penetrated, increased with mitigating caused local temperature in therapeutic process, have dry skin the senses of discomfort such as scorching hot, effectively
While preventing the enzymatic reaction speed of the precursor of photosensitizer substance from declining, the production to singlet oxygen during photodynamic reaction
Rate does not have an impact, and can further improve optical dynamic therapy effect.
Preferably, according to an embodiment of the invention, host includes man-machine interaction unit, Decision Control unit, light source driving
Unit and atomization generating unit, man-machine interaction unit, light source driving units and atomization generating unit respectively with Decision Control unit
Connection, Decision Control unit and atomization generating unit are also connect with atomized spray mechanism respectively.
Specifically, host includes a shell, and man-machine interaction unit is arranged on the housing, and Decision Control unit, light
Source driving unit and atomization generating unit are arranged in the shell.Man-machine interaction unit is a multimedia mould group, is set thereon
There is the liquid crystal display for display, and the touch screen as touch key-press input is installed on liquid crystal display.The liquid crystal
Display screen is connect by UART with Decision Control unit, realizes the human-computer interaction function of host.It can be inputted by the touch screen
The illumination parameter and light sequence irradiation mode of preset difference patient.
Decision Control unit is the control core of entire host, remaining each unit in host is both needed to and Decision Control unit
Connection.During entire optical dynamic therapy, the treatment of irradiator and patient is on the one hand determined by Decision Control unit
Irradiation distance between region forms the light sequence irradiation mode for realizing preferable photodynamic effect, generates corresponding different peak value waves
The light source control signal of long light source shines the corresponding peaks wavelength light from irradiator to the treatment region of patient
Penetrate, and real-time perfoming distance detection and in the liquid crystal display screen display of man-machine interaction unit, to prompt user by irradiator tune
In the whole irradiation distance determined to Decision Control unit；On the other hand it is generated by Decision Control unit control atomization generating unit
Mist particle water containing oxygen sprays the mist particle water from atomized spray mechanism to the treatment region of patient.
Decision Control unit uses ARM series microprocessor, pre-installs the embedded system of WinCE operating system.Micro- place
3 output bits of general purpose I/O Interface for managing device, the lighting and extinguishing as different peak wavelength exposure lights after Phototube Coupling
Signal is controlled, is then transferred in irradiator by light source driving units, thus by different electrodes to each LED chip
It lights and extinguishing is controlled, be irradiated the corresponding peaks wavelength light from irradiator to the treatment region of patient.
Further, host further includes IC card administrative unit and communication unit, and IC card administrative unit and communication unit are divided equally
It is not connect with Decision Control unit；Wherein, IC card administrative unit is used to record the illumination parameter of patient for the first time when treating
It sorts irradiation mode with light, communication unit is used for and external intelligent terminal or server are established and communicated to connect.
Specifically, the IC card administrative unit and communication unit are also disposed at enclosure interior, connect with Decision Control unit.
The structure of the IC card administrative unit realizes that details are not described herein using usually existing technical solution.When treating for the first time, IC card
Administrative unit will be directed to the illumination parameter and light sequence irradiation mode record of different patient setting from man-machine interaction unit
Onto an IC card, the treatment in the subsequent course for the treatment of can directly content of the usage record in IC card be carried out, without again
It is secondary to be inputted by man-machine interaction unit.
The communication unit use USR-C215UART-WiFi module, the module be integrated on hardware MAC, baseband chip,
Transmit Receive Unit and power amplifier etc. support WIFI agreement and ICP/IP protocol, realize host and external intelligence
Terminal or server establish the functions such as communication connection and data transmission.
On the basis of the above embodiments, referring to shown in Fig. 2~Fig. 4, irradiator includes irradiator end cap 201 and setting
Radiation source below irradiator end cap 201；Radiation source includes successively multispectral irradiation mould group 202 disposed in parallel, the
One optical lens array 203 and the second optical lens array 204；Multispectral irradiation mould group 202 is including wiring board 202-1 and extremely
Few one can generate the parallel collimation of different peak wavelengths and the multispectral Sony ericsson mobile comm ab 202- of the uniform light beam of hot spot
On 2, each multispectral orthogonal thereto array arrangement assist side 202-1 of Sony ericsson mobile comm ab 202-2；First optical lens array 203
Above have the side of the refractive lenslet of multiple orthogonal thereto array arrangements towards multispectral irradiation mould group 202, the second optical lens
The side of refractive lenslet on lens array 204 with multiple orthogonal thereto array arrangements is backwards to multispectral irradiation mould group 202, and the
Each lenslet on two optical lens arrays 204 is overlapped and each with the center of each lenslet on the first optical lens array 203
Side corresponds；Multispectral irradiation mould group 202 is 3~5mm, the first optical lens at a distance from the first optical lens array 203
Array 203 is 0.85~1.15 times of the focal length of lenslet at a distance from the second optical lens array 204.
In the present embodiment, the multispectral irradiation mould group in radiation source is used to generate the exposure light of optical dynamic therapy,
It is positioned close to the side of irradiator end cap.
Preferably, at least one radiator fan is additionally provided between multispectral irradiation mould group 202 and irradiator end cap 201
205, for radiating to multispectral irradiation mould group, also can effectively avoid because the heat that multispectral irradiation mould group generates makes patient
Generate sense of discomfort.
In the multispectral irradiation mould group, on wiring board orthogonal thereto array arrangement at least one can generate different peak value waves
The multispectral Sony ericsson mobile comm ab of long parallel collimation and the uniform light beam of hot spot.After being arranged in this way, multiple multispectral solid-state hairs
Optical device forms an area source, and each multispectral Sony ericsson mobile comm ab generates the parallel collimation and light of more different peak wavelengths
The uniform light pencil of spot, thus entire multispectral irradiation mould group can produce it is identical with the quantity of multispectral Sony ericsson mobile comm ab
Respectively independent parallel beamlet, wherein each beamlet is made of more light pencils, and between existing between each beamlet
Gap, more beamlets constitute an angle pencil of ray again, so as to provide enough illumination power densities for optical dynamic therapy；Mostly light
The angle pencil of ray that spectrum irradiation mould group generates successively passes through the first optical lens array and the output of the second optical lens array, realizes to quilt
The Uniform Irradiation of the treatment region of curer.
In practical applications, multispectral irradiation mould group is set as 3~5mm at a distance from the first optical lens array, can expire
The needs of sufficient practical application and assembly technology.First optical lens array is lenslet at a distance from the second optical lens array
The back focal plane that 0.85~1.15 times of focal length, i.e. the second optical lens array are set in parallel in the first optical lens array is attached
Nearby.
Specifically, the lenslet on the first optical lens array and the second optical lens array be regular hexagon or rectangle,
The seamless close arrangement of the first optical lens array and the lenslet on the second optical lens array may be implemented.
Specifically, identical as the focal length of lenslet at a distance from the first optical lens array and the second optical lens array, it can
So that hot spot even results of the irradiation in the treatment region of patient are best.
First optical lens array and the second optical lens array can be used from visible light to infrared light wave-length coverage all
Material processing and fabricating with good light permeability, such as polymethyl methacrylate materials.
In addition, in practical applications, multiple multispectral irradiation mould group close-packed arrays can be formed a plane or cambered surface
Optical dynamic therapy light source, keep its effective irradiated area bigger, the first optical lens array of corresponding setting and second
Optical lens array is also a plane or an arc surface.If multiple multispectral irradiation mould group close-packed arrays form a cambered surface, the first light
The cambered surface that the cambered surface curvature and multiple multispectral irradiation mould group close-packed arrays for learning lens array and the second optical lens array are formed
Cambered surface curvature it is identical.
On the basis of the above embodiments, referring to Figure 5, multispectral Sony ericsson mobile comm ab includes package substrate 501, envelope
It fills and is provided with reflector 502 on the loading end of substrate 501, at least two different peaks are provided in the accommodation space of reflector 502
It is worth the solid-state light emitting element 503 of wavelength；501 two sides of package substrate are provided at least two pairs of electrodes 504, and electrode 504 and solid-state are sent out
The positive and negative anodes of optical element 503 are connected, and electrode 504 is also connect with host；Also closed off at the light-emitting window of reflector 502 be provided with it is micro-
Lens array 505, microlens array 505 is parallel with package substrate 501, and has multiple orthogonal thereto arrays on microlens array 505
The side of the refractive hemispherical microlenses of arrangement is backwards to solid-state light emitting element 503.
In the present embodiment, the transparent materials such as epoxy resin or silica gel are not used to anti-in above-mentioned multispectral Sony ericsson mobile comm ab
It penetrates cup to be filled, but closing is provided with a microlens array, the ruler of the microlens array at the light-emitting window of reflector
The very little size than the light-emitting window of reflector is bigger, so that microlens array can cover all the light-emitting window of reflector, so that
Microlens array is fixed at a distance from each solid-state light emitting element and each solid-state light emitting element is isolated with outside air, also makes
The structure of entire device is more compact, easy to produce and use.After being arranged in this way, each solid-state light emitting element can be made directly exposed
In air, so as to reduce etendue.And refractive index is used to be packaged for the transparent material of n to solid-state light emitting element
Mode, etendue can expand n2Times.
Compared with two kinds of encapsulating structures in the prior art, i.e., using plane packaging structure or in the plane packaging structure
Light output surface on be further added by a hemispherical lens structure, the lenticule battle array being arranged in above-mentioned multispectral Sony ericsson mobile comm ab
Column significantly reduce the thickness of lens, thus greatly reduce energy loss of the light in lens.Therefore, by reflector
Light-emitting window at encapsulate the microlens array, not only solve the efficiency of light extraction problem of multispectral Sony ericsson mobile comm ab, but also
The Space Angle of each different wave length light can be constrained to it is approximately uniform, formed illumination power density distribution uniformly and position one
The large spot of cause can effectively improve the clinical effectiveness of optical dynamic therapy.
Meanwhile the microlens array can collect the light that each solid-state light emitting element is emitted in wide-angle light emitting region
Line, and form the parallel light pencil of identical with the quantity of the lenticule on microlens array more collimations.The result handled in this way
It is, it is different although set up the spatial position of each solid-state light emitting element on same package substrate, but for lenticule battle array
For each lenticule on column, it is on same position that the light of incident different wave length can be seen as by approximation
Point light source.Therefore, the light that each solid-state light emitting element issues is after microlens array collimates, each difference in light pencil
The Space Angle distributional difference of peak wavelength light is constrained for very little, and the light pencil of each difference peak wavelength is in patient
Treatment region is formed by facula position close to identical.Since the lenticule on microlens array is closely arranged, more thin light
The hot spot that beam is formed in the treatment region of patient is connected to each other, and forms illumination power density distribution uniformly and position consistency
Large spot, the clinical effectiveness of optical dynamic therapy can be effectively improved.
Generally, the light-emitting window of reflector be rectangle or circle, the light-emitting window of the shape and reflector of microlens array
Shape matches.In addition, the bottom surface of reflector is preferably consistent with the shape of its light-emitting window, and the height of reflector and micro-
The focal length of mirror is identical.
Preferably, solid-state light emitting element includes the red-light LED core in 620~630nm wave-length coverage with peak wavelength
Piece has the green LED chip of peak wavelength and in 460~470nm wave-length coverage in 520~530nm wave-length coverage
Blue-light LED chip with peak wavelength.
Since the peak value of the extinction spectrum of most photosensitizer is 625nm or 525nm or 465nm, so solid luminescent
Element is preferably respectively in above-mentioned wave-length coverage with red LED chip, green LED chip and the blue-ray LED of peak wavelength
Chip can satisfy most of optical dynamic therapy to the particular demands of the wavelength of light.
Further, the two sides of package substrate are provided with three pairs of electrodes, three pairs of electrodes respectively with red LED chip, green light
LED chip is connected with the positive and negative anodes of blue-light LED chip, and each electrode is also connect with the light source driving units in host, therefore each
Lighting and extinguishing for a LED chip can be independently controlled, convenient to control when carrying out optical dynamic therapy to each LED chip
System.
Preferably, according to an embodiment of the invention, the radius of lenticule is 0.05~0.25mm, the focal length of lenticule is
0.8mm, the distance between rounded bottom surface of contiguous microlens are 0mm.
The radius for the microlens array being arranged at the light-emitting window of reflector is 0.05~0.25mm, the circle of contiguous microlens
When the distance between center of circle of shape bottom surface is 0.1~0.5mm, it is obvious that efficiency of light extraction promotes effect.At this point, the circle of contiguous microlens
The distance between shape bottom surface d=0mm, effective aperture ratio [the π r of microlens array2/(2r+d)2The value of] × 100% is 78.5%.
According to above-mentioned preferred lenticule parameter, the making material of microlens array selects the wave to visible light to infrared light
The light of long range all has the optical glass of good light permeability.Therefore, in the radius of above-mentioned lenticule and adjacent micro-
In the case that the distance between rounded bottom surface of mirror is 0mm, the focal length of each lenticule on the microlens array that made by the material
For 0.8mm.
Further, irradiator further include range sensor and with range sensor connection at a distance from detection circuit, away from
It is connect from detection circuit with host.
Specifically, range sensor and the detection circuit at a distance from range sensor connection are also provided in irradiator,
It can be with the distance between real-time detection irradiator and the treatment region of patient.Decision control in detection circuit and host
Unit connection processed, so that the Decision Control unit in host can be between real-time detection irradiator and the treatment region of patient
Distance, and user is prompted to adjust the distance between the treatment region of irradiator and patient in time, it is ensured that irradiator can
It is irradiated under determining irradiation distance to the treatment region of patient, to obtain preferable therapeutic effect.
Range sensor and digital miniature laser range finder module being used apart from detection circuit, range accuracy can reach ±
The distance value of 1.0mm, real-time measurement send host to binary-coded decimal format.The range sensor and structure apart from detection circuit
It is all made of usually existing technical solution and realizes that details are not described herein.
On the basis of the structure of the irradiator described in above-mentioned each embodiment, referring to shown in Fig. 6, Fig. 6 is that the present invention is real
The radiation response comparison diagram of irradiator and irradiator in the prior art in a kind of optical power therapentic equipment of example offer is provided.Its
In, Fig. 6 (a) is that irradiator described in above-described embodiment projects peak value wave to the white curtain of distance 50cm under dark room conditions
Captured picture after a length of 625nm feux rouges, Fig. 6 (b) are more using multispectral Sony ericsson mobile comm ab composition in the prior art
Spectral illumination light source module group, and remove the irradiation further formed after the first optical lens array and the second optical lens array
Device, captured figure after being 625nm feux rouges to the white curtain of distance 50cm projection peak wavelength under same dark room conditions
Piece.It can clearly be seen that the difference of the two, the hot spot on white curtain are whether equal from illumination from Fig. 6 (a) and Fig. 6 (b)
From the point of view of even property or intensity of illumination, Fig. 6 (a) suffers from significant raising than Fig. 6 (b).
On the basis of the above embodiments, referring to shown in Fig. 7, atomization generating unit include ultrasonic atomizatio room, liquid container,
Air supplying part, heating part, oxygen portion processed, solenoid valve, ozone generating unit and output interface, liquid container and air supplying part are respectively arranged at super
Above and below sound spray chamber, ultrasonic atomizatio room is connect by pipeline with heating part, and oxygen portion processed is connected by pipeline and solenoid valve
Connect, heating part and solenoid valve pass through pipeline respectively and connect through three-way connection with output interface, output interface also with atomized spray machine
Structure connection；Ozone generating unit is arranged on the pipeline of solenoid valve connection three-way connection.
In the present embodiment, atomization generating unit is arranged in the shell of host, mainly for the preparation of the aerosol containing oxygen
Shape particle water.It is mainly comprised the following structure:
Liquid is atomized by ultrasonic atomizatio room using ultrasonic transducer, which can be pure water or be added a small amount of
The clear water of fragrant atmosphere substance.In order to increase atomization yield and to the control of spray patterns, changed in the embodiment of the present invention using double ultrasounds
Can device structure, each ultrasonic transducer configures self-powered circuit, realizes its accomplished continuously or intermittently individually or simultaneously work under mode
Make.In addition, maglev type water level detection switch is provided in ultrasonic atomizatio room, when ultrasonic atomizatio room water level is lower than preset value,
It is automatically stopped the atomization work of ultrasonic transducer, and water shortage report is generated by the liquid crystal display of man-machine interaction unit in host
It is alert.The atomization work of above-mentioned ultrasonic transducer be controlled by the driving circuit being electrical connected with it, and control signal and
Water shortage alarm signal is connected in the Decision Control unit in host.Preferably, ultrasonic atomizatio room in embodiments of the present invention
Maximum atomization ability be 800ml/h.
Liquid container, for holding liquid to be atomized, positioned at the top of ultrasonic atomizatio room, its underpart is equipped with liquid discharge
Mouthful, liquid to be atomized is supplemented by exporting from trend ultrasonic atomizatio room.Preferably, liquid container in embodiments of the present invention
Capacity is 8L.
Air supplying part, for generating wind pressure, the spray water particle that ultrasonic atomizatio room is generated finally can be defeated in the form of mist
It send into atomized spray mechanism.The wind pushing part is made of in the lower section of ultrasonic atomizatio room DC fan and air supply duct, is passed through
Air supply duct is connected with ultrasonic atomizatio room.To realize Boiler pressure control, DC fan is adjusted using PWM in the present invention is implemented
Speed control, rotation speed of fan range: 0-3800rpm.The pwm control signal of above-mentioned blower is connected to the Decision Control list in host
Member.
Oxygen portion processed, the oxygen for being greater than 90% for generating purity, the air extracted in environment pass through omnibus control system
Principle generates oxygen, and the oxygen of output is connected by pipeline with solenoid valve inlet end.After solenoid valve is opened, oxygen is from solenoid valve
Outlet side output, oxygen flow 1.0-1.2l/min.The work in above-mentioned oxygen portion processed is by the host that is electrical connected with it
Decision Control unit control, and the control signal of solenoid valve is also connected in the Decision Control unit in host.
Ozone generating unit makes oxygen molecule that electrochemical reaction occur and generates ozone comprising high pbo glass using electrion
Discharge tube and the high-frequency and high-voltage power supply for making discharge tube generation high voltage corona electric field.One end of high pbo glass discharge tube passes through tracheae
It is connected to solenoid valve, the other end is connected by tracheae with a three-way connection.Enter to make the oxygen in oxygen portion by oneself through solenoid valve
In high pbo glass discharge tube in ozone generating unit.In optical dynamic therapy process, high-frequency and high-voltage power supply is set to close shape
State, therefore oxygen is remained as from the gas that the high pbo glass discharge tube other end exports, the oxygen is through three-way connection and from ultrasound
The mist water particle of spray chamber mixes, the aerosol formed after mixing oxygen concentration with higher and partial pressure of oxygen, spray water
Mist particle water after particle and oxygen mix reaches output interface along tracheae, and further transtracheal is output to atomized spray machine
Structure is sprayed to treatment region.On the other hand, when needing to carry out ozonization, high-frequency and high-voltage power supply is configured to open state, this
When by power supply provide high pressure will make high pbo glass discharge tube generate high voltage corona electric field so that via in high pbo glass discharge tube
Oxygen molecule occur electrochemical reaction, to be in oxygen flow in high pbo glass discharge tube other end output ozone gas
When 1.0-1.2l/min, ozone content is 80-75mg/l in the gas of output.High-frequency and high-voltage power supply opens and closes signal and also connects
It is connected in the Decision Control unit in host.
Heating part stops for heating to by endotracheal gas in the indoor ultrasonic transducer of ultrasonic atomizatio
In the state of work, the air from air supplying part enters the intratracheal of heating part via ultrasonic atomizatio room, and air is heated to be formed
Hot wind, hot wind are sprayed by atomized spray mechanism again via after all tracheaes, to realize to retention in solidifying on inner surface of trachea
Bear water the drying of body.Heating part includes one section of round tube made of the metal material with good heat conductive characteristic, in the outer of round tube
PTC heating element and the NTC temperature sensor for measuring temperature is arranged in wall；One end of round tube passes through tracheae and ultrasonic atomizatio room
Gas outlet be connected, the other end is connected by tracheae with three-way connection.The control signal and NTC temperature of above-mentioned PTC heating element
The detection signal of degree sensor is also connected in the Decision Control unit in host.
Specifically, the modeling muscle that the tracheae of above-mentioned connection various components is all made of that internal diameter is 20mm enhances hose.
On the basis of the above embodiments, referring to shown in Fig. 7 and Fig. 8, atomized spray mechanism includes injection spray pipe 206, catchments
Device 207 and micro pump 208, the side of injection spray pipe 206 are provided with into water and meet mouth 206-1, and the side of water collector 207 is provided with row
Water meets mouth 207-1, and micro pump 208 meets mouth 206-1 with water inlet by drainpipe respectively and draining meets mouth 207-1 and connect；It catchments
Device 207 is set on the lower end of injection spray pipe 206, and water collector 207 includes lower cover 207-3 and upper end cover 207-2, lower cover
The horn-like boss 207-4 extended to the direction upper end cover 207-2 is provided on 207-3, the periphery of boss 207-4 is provided with multiple
U-type groove, so that the condensed water on 206 inner wall of injection spray pipe is entered in water collector 207 by U-type groove.
In the present embodiment, atomized spray mechanism is arranged in irradiator, is occurred by the atomization in tracheae and host single
Member connection, is mainly used for the mist particle water containing oxygen of jet atomization generating unit preparation.
Specifically, the upper end of injection spray pipe be equipped with for connect be atomized generating unit output interface tracheae, lower end according to
Upper end cover after secondary irradiator end cap, the first optical lens array, the second optical lens array across irradiator with water collector
Using threaded connection.The water inlet of micro pump connects mouth with the water inlet on water collector upper end cover by drainpipe and connect, water outlet
Mouth connects mouth with the draining on injection spray pipe by drainpipe and connect.The other end that water inlet connects mouth is located at the inside of injection spray pipe, and connects
There is drainpipe, which is set in the pipe that the upper end of injection spray pipe is connect with the output interface of atomization generating unit, and
The drainpipe is also connected to close at the position of the output interface of atomization generating unit.Preferably, above-mentioned drainpipe is all made of fluorine
Sebific duct, internal diameter 3mm, outer diameter 5mm.
The condensation water body being collected in water collector is extracted out by drainpipe by micro pump, via flowing to after another drainpipe
The pipe that the upper end of injection spray pipe is connect with the output interface of atomization generating unit, therefore by being set in the endotracheal draining
The condensation water body of pipe discharge can finally flow back in the ultrasonic atomizatio room of atomization generating unit along the inner surface of trachea.Above-mentioned Miniature water
Pump uses brushless peristaltic pump, is electrically connected with the Decision Control unit in host.
Further, upper end cover and lower cover that water collector includes, the two are snugly assembled.The one of upper end cover
Side is equipped with circular hole, and draining connects mouth and is snugly from top to bottom pressed into from the circular hole, and the bottom that draining connects mouth extension end opens up
One cross recess, after the length of extension end is upper end cover and lower cover assembly, the cross recess just with the bottom connection of lower cover
It touches, the ponding in such water collector can be cleaned by micro pump.It is provided on lower cover to the extension of upper end cover direction
Horn-like boss, the overall diameter of the boss has the internal diameter of screw thread one end 1mm small or so than injection spray pipe, uniform in the periphery of boss
Several U-type grooves are distributed, groove depth is preferably 0.7mm, is flowed down in this way along the tracheae of injection spray pipe upper end connection and spraying inside pipe wall solidifying
Bearing water body will be entered in water collector by U-type groove, and the mist water particle in injection spray pipe is then from water collector lower end by boss shape
At horn opening output.
Preferably, the junction of injection spray pipe 206 and irradiator is additionally provided with nut 210 and sealing ring 209, injection spray pipe 206
Lower end and the junction of water collector 207 also are provided with sealing ring 209, can prevent condensation water body from oozing out from junction in this way, influence
The treatment of patient is experienced.
Shown in referring further to Figure 2, the atomized spray mechanism on irradiator when being arranged, except on irradiator end cap 201
It is provided with outside through-hole 211, is also respectively provided with one in the center of the first optical lens array 203 and the second optical lens array 204
A through-hole 211, these three 211 central coaxials of through-hole, injection spray pipe 206 is from top to bottom across the irradiator end cap 201 of irradiator, the
Then the through-hole 211 of one optical lens array 203, central coaxial on the second optical lens array 204 connects with water collector 207
It connects.Two apertures are also provided with beside the through-hole 211 of the first optical lens array 203 and the second optical lens array 204
212, the drainpipe that mouth 207-1 is connect is connect with the draining on water collector 207 and sequentially passes through above-mentioned aperture 212, is then attached to position
Pass through drainpipe and injection spray pipe in the water outlet of the water inlet of the micro pump 208 on irradiator end cap 201, micro pump 208
Water inlet on 206 meets mouth 206-1 and is connected.
In conclusion one kind that entire atomized spray process is shown in FIG. 7 is specific to implement structure, wherein atomization
Generating unit is arranged in the shell of host, and atomized spray mechanism is then arranged inside irradiator, and the two is carried out by tracheae
Air circuit connection.In optical dynamic therapy, the mist water particle containing oxygen generated by atomization generating unit is defeated by tracheae
It send into atomized spray mechanism, the treatment region irradiated to exposure light is sprayed.After therapeutic process, atomized spray machine
The condensation water body that micro pump in structure will be drained automatically in water collector, and surpassing in atomization generating unit is flowed back by tracheae
In sound spray chamber；Meanwhile the air stream by being heated dries the condensation water body of each pipeline inner wall, finally using smelly
Oxygen carries out the disinfection and sterilization of strong oxidizing property to each pipeline, prevents pipeline inner wall and breeds bacterial propagule and mildew.
Remove irradiator on atomized spray mechanism water collector after, environment temperature be 15-35 DEG C, relative humidity 40-
Under conditions of 80%.It is collected using manual method every 20 with the maximum atomization ability continuous work of 800ml/h ultrasonic atomizatio room
The condensation water inventory oozed in continuous time minute from injection spray pipe.Test result shows that be averaged every condensation being collected into 20 minutes
Water inventory is 10-13ml.According to above-mentioned test result, it is preferable that the overall diameter of the water collector in the embodiment of the present invention is 60mm,
Height is 12mm, the capacity of water collector about 16ml, during ultrasonic atomizatio indoor ultrasonic transducer work, micro pump every
It automatically turns on 30 seconds within 20 minutes and water collector is drained, so as to avoid water collector spilling water phenomenon occur completely.
On the basis of the structure described in above-mentioned each embodiment, in a kind of implementation, referring to shown in Fig. 9, host
901 and irradiator 902 by automatically resistance stop multi-joint suspension arm 903 connection, it is by wrapping which, which stops multi-joint suspension arm 903,
Include the connection with 6 damping joints that upper arm parts 9031, lower arm part 9032, wrist 9033 and terminal connection portion 9034 form
Arm, the support portion 904 by being rigidly fixed in 901 central top of host realize the mechanical connection of itself and host 901.Irradiator
Automatically controlled signal on 902 is concentrated on the socket being connected at the top of it, is stopped on multi-joint suspension arm 903 by being built in automatic resistance
With the call wire in annulus D type shield irdome 9035 by the socket and host 901 light source driving units, Decision Control unit into
Row is electrically connected.The mist water particle containing oxygen that atomization generating unit in host 901 generates then passes through tracheae and is sent
To the atomized spray structure being arranged in irradiator 902.
It not will cause the distortion of tracheae in adjustment 902 spatial attitude process of irradiator to realize, stop close in automatic resistance more
The two band annulus D types that have been respectively arranged below of the upper arm parts 9031 and lower arm part 9032 that save suspension arm 903 protect irdome 9035, should
One end of tracheae is connected to the injection spray pipe on irradiator 902, then sequentially passes through 9031 lower section of lower arm part 9032 and upper arm parts
After the annulus on annulus D type shield irdome 9035, the other end is connected to the output interface in 901 shell back plate of host.
It is additionally provided with hydraulic damper inside lower arm part 9032, when the spatial attitude and quilt for manually adjusting irradiator 902
When the distance between treatment region of curer, due to hindering the hydraulic damper and damping that stop in multi-joint suspension arm 903 automatically
The spatial attitude of the effect in joint, irradiator 902 can be automatically kept, and be locked without other additional locking mechanisms to cantilever joint
It is fixed.Automatic resistance, which stops multi-joint suspension arm 903, can realize that 902 upper-lower height 50cm of irradiator, left-right rotary is turn 90 degrees and upper nutation
The adjustment within the scope of 90 degree is faced upward, so that patient be facilitated to receive treatment using sitting posture or prone position, while easily realizing irradiation
The adjustment of distance between device 902 and the treatment region of patient, is in it on position of desired distance.
Further, be provided on the shell of host 901 includes in man-machine interaction unit for treating parameter and state
The liquid crystal display 905 of display and the touch screen and IC inputted for treating parameter being arranged on the liquid crystal display 905
The IC card seat 906 of card administrative unit.
In 901 enclosure interior of host, it is atomized the heavier-weight of generating unit, therefore it is intracorporal to be installed in 901 shell of host
Lower part, other units are mounted on the intracorporal top of 901 shell of host, and specific location is determined according to 901 housing interior structure of host,
It is not indicated in figure, herein also with no restriction.
Be additionally provided with automatically controlled signal socket in the 901 shell back plate of host, the automatically controlled signal socket in host 901 with
Light source driving units are connected with Decision Control unit.In addition, output interface is located at the top of 901 shell back plate of host, therefore mist
Ultrasonic mist can be flowed back to along inner surface of trachea under the effect of gravity by changing the condensation water body that each inner surface of trachea in generating unit is formed
Change indoor.Knob 907 is respectively arranged at left and right sides of 901 shell of host, 901 housing bottom of host is provided with universal caster wheel
908, wherein two universal caster wheels 908 for being located at shell front have braking mechanism, facilitate the movement of whole device and position solid
It is fixed.
On the basis of structure based on light power described in above-mentioned each embodiment and ultrasonic atomizatio combination therapy device, this
Inventive embodiments also provide a kind of smooth power and ultrasonic atomizatio combination therapy method, and referring to Fig.1 shown in 0, this method is specifically included that
1001, host determines treatment time and irradiation distance, and sort according to the light of input according to the illumination parameter of input
Irradiation mode exports corresponding light source control signal, so that irradiator meets light sequence irradiation mould according to light source control signal generation
The parallel collimation and the uniform exposure light of hot spot of at least one different peak wavelengths of formula, and when under irradiation distance according to treating
Between the treatment region of patient is irradiated；Illumination parameter include at least one exposure light peak wavelength and with controlled
The light energy density and illumination power density for the exposure light that the treatment region for the treatment of person matches；
1002, host prepares and exports the mist particle water containing oxygen, so that atomized spray mechanism is in irradiator pair
During the treatment region of patient is irradiated, mist particle water is sprayed to the treatment region of patient.
In step 1001, different patient and its different treatment region are realized in order to targetedly a
Property therapeutic scheme, i.e., different patient is according to different irradiation distances, different treatment times and different peak value wave
Light sequence irradiation mode of long light etc. is irradiated to obtain preferable therapeutic effect, then is needed through the human-computer interaction in host
Default illumination parameter and light the sequence irradiation mode for the patient of unit.
Specifically, illumination parameter includes the peak wavelength of at least one exposure light and the treatment region phase with patient
The light energy density and illumination power density of matched exposure light.
Preferably, according to an embodiment of the invention, light sequence irradiation mode includes the first light sequence irradiation mode, the second light
The irradiation mode that sorts and third light sequence irradiation mode；
First light sequence irradiation mode is that a kind of exposure light of peak wavelength repeats the treatment region of patient
Continuous or segmentation irradiation, until stopping when reaching its preset light energy density；Second light sequence irradiation mode is at least
The exposure light of two kinds of different peak wavelengths carries out duplicate continuous or segmentation to the treatment region of patient simultaneously and irradiates, when it
A kind of middle exposure light stops irradiation when reaching its preset light energy density, remaining exposure light continues the treatment to patient
Region is irradiated, until all exposure lights stop irradiation when reaching its preset light energy density；Third light sequence spoke
Duplicate company is carried out to the treatment region of patient according to the exposure light cycle alternation that mode is at least two different peak wavelengths
Continuous or segmentation irradiation, stops irradiation when one of exposure light reaches its preset light energy density, remaining exposure light after
It is continuous that the treatment region of patient is irradiated, until stopping when all exposure lights reach its preset light energy density
Irradiation.
It, should after the peak wavelength for the exposure light for being determined to that the treatment region of patient is made to reach preferable therapeutic effect
The illumination power density of the exposure light of peak wavelength is corresponding with the distance between irradiator and the treatment region of patient
's.Therefore, the Decision Control unit in host can be close according to the peak wavelength of the exposure light and the illumination power of the exposure light
Degree, determines irradiation distance, i.e. the distance between the treatment region of irradiator and patient.It in turn, can be according to the exposure light
Illumination power density and need light energy density to be achieved, determine treatment time, i.e. treatment of the irradiator to patient
The time that region is irradiated.
Preferably, in one possible implementation, the step of determining irradiation distance according to illumination parameter can be according to such as
Under type is implemented:
S1, the distance-illumination saturation effect database for establishing exposure light, distance-illumination saturation effect data
Library is used to indicate exposure light and illumination power density average value of the target target surface under different distance；
S2, it is based on distance-illumination saturation effect database, is irradiated using linear interpolation method according in illumination parameter
The illumination power density of light determines irradiation distance.
Due to the exposure light of different peak wavelengths illumination power density and irradiator and patient treatment region it
Between distance be corresponding.Decision Control unit in host is previously stored with distance-illumination saturation effect database,
The relational database is according under the different irradiation distances between irradiator and target target surface, and the exposure light of different peak wavelengths exists
The corresponding relationship of illumination power density average value in the uniform light spots region of target target surface and establish, i.e., a kind of peak wavelength
Exposure light different illumination power densities is respectively corresponded under different irradiation distances.
Illumination power density refers to the gross energy in unit illuminating area, receiving illumination on the unit time, unit mW/
cm2.Illumination power density is the basic parameter of PDT dosimeter, it determines that illumination locally receives photon intensity, is presently believed to be
Determine the key factor of PDT curative effect.The illumination power density that the optical power therapentic equipment of the prior art provides typically refers to light source
The illumination power density of Exit positions, in practical applications, due to the difference of distance between light source and irradiated site, arrival is controlled
The illumination power density of the treatment region for the treatment of person be it is uncertain, especially by change light source drive current size realize illumination
The optical power therapentic equipment of power density adjustment, inherently changes in the illumination power density of light source Exit positions.Although
Optical sensor is arranged in the treatment region of patient for some optical power therapentic equipments or CCD carries out illumination power density and examines in real time
It surveys, then adjusting distance between light source and irradiation area by modes such as automatic or manuals makes the illumination power density for the treatment of region
Measured value is in range of set value, although this scheme realizes the accurate of the therapentic part illumination power density of patient
Control, but since the irradiation light that set optical sensor or CCD generate part to therapentic part is blocked, to influence treatment region
The optical dynamic therapy effect in domain, and the program also will increase the complexity of device and the triviality of use process.
In the present embodiment by way of establishing distance-illumination saturation effect database, can accurately it use
Linear interpolation method determines corresponding irradiation distance according to the corresponding illumination power density of the exposure light, so that irradiator can be
It is irradiated under determining irradiation distance to the treatment region of patient, to obtain preferable therapeutic effect.
Specifically, the specific establishment process of distance-illumination saturation effect database can refer to following process and carry out:
First it is defined as follows parameter:
The uniformity: Ai=Ei/Ep (1)
Coefficient of uniformity: E=Se/S (2)
In formula, Ei is the illumination power density that light irradiates target target surface glazing spot certain point；Ep is that light irradiates target
Illumination power density peak value on target surface in hot spot；S is the gross area that light irradiates target target surface glazing spot；Se is light irradiation
The area in the region Ai >=0.85 in target target surface glazing spot；The region of Ai >=0.85 is defined as uniform light spots region.
One target target surface is set in the irradiation position light-emitting face 100mm apart from irradiator, is thrown respectively to target target surface
It penetrates the feux rouges within the scope of wavelength 620-630nm with peak wavelength, there is peak wavelength within the scope of wavelength 520-530nm
Green light and the blue light within the scope of wavelength 460-470nm with peak wavelength, measure each peak wavelength using light irradiatometer
Illumination power density of the exposure light in target target surface glazing spot.
Specifically, target target surface is divided into 10 × 10mm square measurement subregion, measurement target is each sub-regions
The illumination power density values for measuring target are denoted as Ei by geometric center point, and the uniformity Ai of measurement target is calculated according to formula (1).
Illumination power density values Ei in the region Ai >=0.85 is carried out to take its average value after adding up, which is demarcated as corresponding peak value wave
The illumination power density values on long exposure light irradiated site surface in distance 100mm.Using 20mm as distance increment, change irradiation
The irradiation light-emitting face of device repeats the above process at a distance from target target surface, until distance value is 300mm, completes calibration test.
By the above process, the distance between irradiator and target target surface are established from 100mm to 300mm, and is changed by 20mm increment
Distance-illumination saturation effect database.
Since the Sony ericsson mobile comm ab used in irradiator has the advantages that long service life, light intensity attenuation are small, on
Stating more can chronically be stored in determining in host by distance-illumination saturation effect database that calibration measurement is established
In plan control unit, the treatment region difference peak wavelength exposure light for completing patient indirectly by the measurement adjusted the distance is realized
Illumination power density average value Accurate Determining.In addition, can increase simultaneously when carrying out periodic inspection to above-mentioned distance-
Illumination saturation effect database is carried out re-scaling measurement and be updated, to guarantee that illumination power density average value is surveyed indirectly
Fixed accuracy, the database after re-scaling measurement pass through the communication unit in host and establish the intelligent terminal or clothes of connection
Business device is updated.
After the treatment time and irradiation distance that patient has been determined, the Decision Control unit in host sorts according to light
Irradiation mode exports corresponding light source control signal, and light source control signal is transferred into light source driving units, to being connected thereto
Irradiator in each LED light source independent constant-current source circuit electric current implement on-off control, to realize different peak value waves
The open and close of long exposure light.
In three kinds of light sequence irradiation mode that light sequence irradiation mode includes, comprising duplicate continuous or be segmented both
Radiation mode.Under identical illumination power density, the treatment region of patient obtains same light energy density, segmentation
Radiation mode needs more treatment times than continuous irradiation mode.But in segmentation radiation mode, due to target site
The oxygen concentration of tissue and peripheral vessels is higher, and exposure light irradiation can generate more fully singlet oxygen, to obtain better
Photodynamic effect, in addition, segmentation radiation mode, which can reduce the heat generated due to light source, gives patient bring discomfort.Cause
This, in practical application, generalling use segmentation radiation mode in three kinds of light sequence irradiation modes to be treated.
Referring to Fig.1 shown in 1, Figure 11 is a kind of smooth power provided in an embodiment of the present invention and ultrasonic atomizatio combination therapy method
In in the case where the first light sorts irradiation mode a kind of exposure light of peak wavelength in the control that lighting with extinguishing be segmented under radiation mode
Signal schematic representation processed.In figure, ToffFor dark cycle time, exposure light is in OFF state during this period；TonFor bright cycle time,
Exposure light is in the illuminating state under pulsewidth modulation during this period；F is the frequency that pulsewidth modulation is carried out to exposure light；tonFor pulsewidth
The light irradiation time of modulation；tcThe treatment region of patient is set to reach preset light energy for the exposure light of the peak wavelength
Treatment time required for density.
Wherein, the treatment region of patient reaches treatment time t required for preset light energy densityc(unit:
Second), i.e. the first light sequence irradiation mode under required treatment time be calculated as follows:
tc=H0/[(E0×D1×D2)×1000] (3)
Wherein, E0For a kind of illumination power density of the exposure light of peak wavelength, unit mW/cm2；H0For a kind of peak value
The light energy density of the exposure light of wavelength, unit J/cm2；D1The irradiation duty ratio of exposure light, D when for pulsewidth modulation1=ton
×f；D2For bright cycle time duty ratio, D2=Ton/(Ton+Toff)。
In bright cycle time TonPeriod, the irradiation of exposure light are based on photodynamic reaction process machine using non-inverting output
What reason considered.Since excitation state will be transitted to after absorbing the light energy more than threshold value in ground state photosensitizer molecule, it is in
The photosensitizer molecule of excitation state first transits to triplet state, and then decay returns to ground state.Photosensitizer molecule and oxygen in triplet state
Molecule occurs redox reaction and releases energy, and forms toxicant singlet oxygen1O2, singlet oxygen destroy pathological tissues or
Surrounding blood vessel is to kill pathological tissues.Therefore, corresponding with above-mentioned photodynamic reaction process is irradiation light in tonPeriod
The light energy t of generationon×E0The light energy of threshold value needed for photosensitizer molecule need to be met and exceeded from ground state transition to excitation state,
And in 1/f-tonPeriod stops light irradiation, and the photosensitizer molecule of excitation state releases energy, and forms toxicant singlet oxygen and declines
Ground state is changed back to, is so recycled.In embodiments of the present invention, it is preferable that the frequency f for carrying out pulsewidth modulation to exposure light is fixed as
1.75KHz；The light irradiation time t of pulsewidth modulationonValue range are as follows: 1/2f≤ton≤1/f.Specifically, host can be passed through
In man-machine interaction unit to tonIt is set, sets step pitch 50usec.
Singlet oxygen during photodynamic reaction1O2Production will to consume oxygen in target site tissue and peripheral vessels dense
Degree, excessive oxygen concentration consumption will reduce singlet oxygen1O2Yield cannot continue so as to cause optical dynamic therapy effect, therefore,
In the light source control signal lighted and extinguished arranges, each bright cycle time TonFollowed by primary dark cycle time Toff, with
It realizes and segmentation irradiation is implemented to the treatment region of patient.Utilize dark cycle time Toff, target site tissue and peripheral vessels
Effectively restore oxygen concentration from body processes system, form sufficient singlet oxygen when enabling to irradiate next time, to reach more
Good therapeutic effect.In embodiments of the present invention, it is preferable that bright cycle time TonRange be 1.0~10.0sec；The dark period
Time ToffRange be 1.0~10.0sec.It specifically, can be by the man-machine interaction unit in host to TonAnd ToffIt carries out
Setting sets step pitch 0.1sec.
In the segmentation irradiation process in above-mentioned first light sequence irradiation mode, if by dark cycle time ToffIt is set as
Zero, and by the light irradiation time t of the pulsewidth modulation in the bright periodonBe set as 1/f, then can treatment region to patient it is real
Apply continuous irradiation.
Since many photosensitizers have multiple characteristic absorption peaks on its extinction spectrum, such as the widely used δ-in clinic
Aminolevulinic acid (5-ALA), substantially δ-aminolevulinic acid do not have light sensitive characteristic, it is by enzymatic reaction synthesized human
Endogenous photosensitizers protoporphyrin PpIX substance and play photosensitization.The extinction spectrum figure of protoporphyrin PpIX is in wavelength 410nm, wave
Long 510nm, wavelength 545nm, wavelength 580nm and wavelength 630nm all have absorption peak.In optical dynamic therapy, selection and original
The exposure light of multiple peak wavelengths similar in multiple absorption peaks of porphyrin PpIX extinction spectrum figure carries out joint radiation treatment, energy
Therapeutic effect more better than a kind of above-mentioned exposure light of peak wavelength is obtained, and required treatment time shortens.Therefore, upper
On the basis of stating the first light sequence irradiation mode, and it is provided with the second light sequence irradiation mode and third light sequence irradiation mode,
It is that the exposure light at least two different peak wavelengths repeats the treatment region of patient in both modes
It is continuous or segmentation irradiation.
Referring to Fig.1 shown in 2, Figure 12 is a kind of smooth power provided in an embodiment of the present invention and ultrasonic atomizatio combination therapy method
In in the case where the second light sorts irradiation mode the exposure lights of at least two peak wavelengths be segmented lighting under radiation mode and extinguishing
Control signal schematic representation.In figure, tc1The treatment region of patient is set to reach default for the exposure light of the first peak wavelength
Light energy density required for treatment time, tc2Make the treatment region of patient for the exposure light of second of peak wavelength
Reach treatment time required for preset light energy density, tc3Make patient for the exposure light of the third peak wavelength
Treatment region reaches treatment time required for preset light energy density, tcRequired under the second light sequence irradiation mode
Treatment time.
Wherein, the exposure light of the first peak wavelength makes the treatment region of patient reach preset light energy density
Required treatment time tc1(unit: second), the exposure light of second of peak wavelength make the treatment region of patient reach pre-
If light energy density required for treatment time tc2(unit: second), the exposure light of the third peak wavelength make patient
Treatment region reach treatment time t required for preset light energy densityc3The sequence irradiation of (unit: second) and the second light
Required treatment time t under modec(unit: second) is calculated as follows:
tc1=H10/[(E10×D1×D2)×1000] (4)
tc2=H20/[(E20×D1×D2)×1000] (5)
tc3=H30/[(E30×D1×D2)×1000] (6)
tc=Max (tc1, tc2, tc3) (7)
Wherein, E10、E20And E30The respectively exposure light of the first peak wavelength, second of peak wavelength exposure light and
The illumination power density of the exposure light of three kinds of peak wavelengths, unit mW/cm2；H10、H20And H30Respectively the first peak value wave
The light energy density of the exposure light of long exposure light, second of peak wavelength exposure light and the third peak wavelength, unit are
J/cm2。
After starting to carry out the optical dynamic therapy under the second light sequence irradiation mode, the Decision Control unit in host is not to
Light energy density value with the exposure light of peak wavelength is accumulated, when the illumination energy of the exposure light of one of peak wavelength
When metric density value accumulated value reaches its preset value, Decision Control unit stops putting out for the exposure light of the time corresponding peak wavelength
The light source control signal to go out, and so on, until accumulated time reaches tcValue.
It should be noted that under the sequence irradiation mode of the second light shown in Figure 12 the exposure light of different peak wavelengths point
In the bright light source control signal with extinguishing, in bright cycle time, exposure light is to carry out non-inverting output with fixed frequency f.
Referring to Fig.1 shown in 3, Figure 13 is a kind of optical dynamic therapy and ultrasonic atomizatio complex method provided in an embodiment of the present invention
In in the case where third light sorts irradiation mode the exposure lights of at least two peak wavelengths be segmented lighting under radiation mode and extinguishing
Control signal schematic representation.In figure, tc1The treatment region of patient is set to reach default for the exposure light of the first peak wavelength
Light energy density required for treatment time, tc2Make the treatment region of patient for the exposure light of second of peak wavelength
Reach treatment time required for preset light energy density, tc3Make patient for the exposure light of the third peak wavelength
Treatment region reaches treatment time required for preset light energy density, tcRequired under third light sequence irradiation mode
Treatment time.
Wherein, the exposure light of the first peak wavelength makes the treatment region of patient reach preset light energy density
Required treatment time tc1(unit: second), the exposure light of second of peak wavelength make the treatment region of patient reach pre-
If light energy density required for treatment time tc2(unit: second), the exposure light of the third peak wavelength make patient
Treatment region reach treatment time t required for preset light energy densityc3The sequence irradiation of (unit: second) and third light
Required treatment time t under modec(unit: second) is calculated as follows:
tc1=H10/[(E10×D1×D2)×1000] (8)
tc2=H20/[(E20×D1×D2)×1000] (9)
tc3=H30/[(E30×D1×D2)×1000] (10)
tc=tc1+tc2+tc3 (11)
Wherein, E10、E20And E30The respectively exposure light of the first peak wavelength, second of peak wavelength exposure light and
The illumination power density of the exposure light of three kinds of peak wavelengths, unit mW/cm2；H10、H20And H30Respectively the first peak value wave
The light energy density of the exposure light of long exposure light, second of peak wavelength exposure light and the third peak wavelength, unit are
J/cm2。
After starting to carry out the optical dynamic therapy under third light sequence irradiation mode, the Decision Control unit in host is not to
Light energy density value with the exposure light of peak wavelength is accumulated, when the illumination energy of the exposure light of one of peak wavelength
When metric density value accumulated value reaches its preset value, the exposure light that Decision Control unit stops the time corresponding peak wavelength is extinguished
Light source control signal, and so on, until accumulated time reaches tcValue.
It should be noted that the sort different peak wavelength exposure lights under irradiation mode of third light in Figure 13 are lighted and are put out
In the light source control signal to go out, in bright cycle time, exposure light is to carry out non-inverting output with fixed frequency f.
Host exports corresponding light source control signal according to above-mentioned light sequence irradiation mode, and is sent in irradiator.
Irradiator generates the parallel standard for meeting at least one different peak wavelengths of light sequence irradiation mode according to the light source control signal
The straight and uniform exposure light of hot spot, and above-mentioned obtain is in by adjusting the distance between irradiator and the treatment region of patient
Under irradiation distance out, finally it is irradiated according to the above-mentioned treatment time obtained to the treatment region of patient.It is dynamic in light
It, can it is preferable to use described in the embodiment of the present invention according to the disease for the photosensitizer and treatment that optical dynamic therapy uses in power treatment
Any mode in first light sequence irradiation mode, the second light sequence irradiation mode or third light sequence irradiation mode.Specifically
For, if the photosensitizer used only one characteristic absorption peak on extinction spectrum figure, although there are also other absorption peaks,
But its peak value very little when compared with characteristic absorption peak, it is clear that the light power and ultrasonic atomizatio described in the embodiment of the present invention are compound
Selection and a kind of exposure light of peak wavelength similar in photosensitizer characteristic absorption peak on the basis of therapeutic device, and according to the first light
It is the most appropriate that sequence irradiation mode, which carries out optical dynamic therapy,.
And to endogenous photosensitizers protoporphyrin PpIX etc., according to the second sequence irradiation mode or third light sequence irradiation mode
Optical dynamic therapy is carried out, better therapeutic effect can be obtained.According to the optical characteristics of tissue, due to organizing the scattering to exposure light
Rate and absorptivity have differences, and the penetrating power of the exposure light of different peak wavelengths in the tissue is different, and the wavelength of exposure light is got over
Small penetration depth within the organization is more shallow.It sorts under irradiation mode in the second light, the exposure light of each peak wavelength is in the bright period
It is to be irradiated in the treatment region of patient simultaneously in time, generates singlet oxygen in photosensitizer molecule redox reaction
While will consume the oxygen concentration of skin shallow-layer and deep tissues, since the capillary of shallow layer tissue is distributed opposite deep tissues
Want sparse, the speed of shallow layer tissue's recovery oxygen concentration is slower than deep tissues within same dark cycle time, therefore is easy to make
At shallow layer tissue's anoxic.Therefore, sort irradiation model comparision with third light, and the second light sorts irradiation mode more suitable for such as daylight
The lesions such as keratosis, bowen's disease are stored in the skin disease of organism internal ratio deep place.It sorts under irradiation mode in third light, respectively
The exposure light of a peak wavelength is different peak value waves in the treatment region for being alternately irradiated to patient within bright cycle time
Long exposure light has longer dark cycle time, and shallow layer tissue has time enough to restore its oxygen concentration in organism, therefore,
It sorts with the second light and irradiates model comparision, third light sequence irradiation mode is stored in organism more suitable for lesions such as such as acne vulgaris
The disease of inner skin surface location.
In step 1002, the mist particle water containing oxygen of atomized spray authorities host output, is irradiating
During device is irradiated the treatment region of patient, the mist water is sprayed to the treatment region of patient
Grain is increased with mitigating caused local temperature in therapeutic process, has dry skin the senses of discomfort such as scorching hot, effectively prevent photosensitizer substance
Precursor enzymatic reaction speed decline while, the yield of singlet oxygen during photodynamic reaction is not had an impact,
It can further improve optical dynamic therapy effect.
A kind of smooth power provided in an embodiment of the present invention is with ultrasonic atomizatio combination therapy device and treatment method, it can be achieved that right
The Uniform Irradiation of the treatment region of patient, and illumination power density distribution of the exposure light in the treatment region of patient
Curved surface height is similar, and the efficiency of light energy utilization is high, can effectively enhance therapeutic effect；Meanwhile, it is capable to targetedly be controlled different
Treatment person and its different treatment region are according to different irradiation distances, different treatment times and the progress such as irradiation mode of sorting of not sharing the same light
Irradiation realizes personalized therapeutic scheme, can obtain preferable therapeutic effect.In addition, also being prepared by host containing aerobic
The mist particle water of gas, during treatment region of the irradiator to patient is irradiated, to controlling for patient
Treat the area spray mist particle water, increased with mitigating caused local temperature in therapeutic process, have dry skin it is scorching hot etc. no
Suitable sense, while effectivelying prevent the enzymatic reaction speed of the precursor of photosensitizer substance to decline, to single during photodynamic reaction
The yield of line state oxygen does not have an impact, and can further improve optical dynamic therapy effect.
It should be noted that for simple description, therefore, it is stated as a series of for the embodiment of the above method
Combination of actions, but those skilled in the art should understand that, the present invention is not limited by the sequence of acts described.Secondly,
Those skilled in the art should also know that the embodiments described in the specification are all preferred embodiments, related movement
It is not necessarily essential to the invention.
It should be noted that smooth power provided in an embodiment of the present invention and ultrasonic atomizatio combination therapy method and aforementioned implementation
Light power described in example and ultrasonic atomizatio combination therapy device belong to identical technical concept, unmentioned in embodiment of the method
Content can refer to the explanation in aforementioned device embodiment, and details are not described herein.
In the above embodiment of the invention, it all emphasizes particularly on different fields to the description of each embodiment, does not have in some embodiment
The part of detailed description, reference can be made to the related descriptions of other embodiments.
The foregoing is merely presently preferred embodiments of the present invention, is not intended to limit the invention, it is all in spirit of the invention and
Within principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of smooth power and ultrasonic atomizatio combination therapy device, which is characterized in that described device includes:
Host for determining treatment time and irradiation distance according to preset illumination parameter, and sorts according to preset light and irradiates
Mode exports corresponding light source control signal；It is also used to prepare the mist particle water containing oxygen；
Irradiator is connect with the host, and for receiving the light source control signal, generation meets the light sequence irradiation mould
The parallel collimation and the uniform exposure light of hot spot of at least one different peak wavelengths of formula, and according to institute under the irradiation distance
Stating treatment time is irradiated the treatment region of patient；
Atomized spray mechanism is connect with the host, for receiving the mist particle water, and the treatment to patient
Mist particle water described in area spray.
2. the apparatus according to claim 1, which is characterized in that the irradiator includes irradiator end cap and is arranged in institute
State the radiation source below irradiator end cap；
The radiation source includes successively multispectral irradiation mould group, the first optical lens array and the second optical lens disposed in parallel
Lens array；The multispectral irradiation mould group includes wiring board and at least one can generate the parallel collimation of different peak wavelengths
And the multispectral Sony ericsson mobile comm ab of the uniform light beam of hot spot, each multispectral orthogonal thereto array arrangement of Sony ericsson mobile comm ab exist
On the wiring board；The side of refractive lenslet on first optical lens array with multiple orthogonal thereto array arrangements
Towards the multispectral irradiation mould group, the refractive on second optical lens array with multiple orthogonal thereto array arrangements is small
Each lenslet of the side of lens in the multispectral irradiation mould group, second optical lens array and first light
The center for learning each lenslet on lens array is overlapped and each side corresponds；The multispectral irradiation mould group and first light
The distance for learning lens array is 3~5mm, and first optical lens array is institute at a distance from second optical lens array
0.85~1.15 times for stating the focal length of lenslet.
3. the apparatus of claim 2, which is characterized in that the multispectral Sony ericsson mobile comm ab includes package substrate,
It is provided with reflector on the loading end of the package substrate, at least two different peaks are provided in the accommodation space of the reflector
It is worth the solid-state light emitting element of wavelength；The package substrate two sides are provided at least two pairs of electrodes, and the electrode and the solid-state are sent out
The positive and negative anodes of optical element are connected, and the electrode is also connect with the host；It also closes off and is provided at the light-emitting window of the reflector
Microlens array, the microlens array is parallel with the package substrate, and has on the microlens array multiple orthogonal thereto
The side of the refractive hemispherical microlenses of array arrangement is backwards to the solid-state light emitting element.
4. device according to claim 3, which is characterized in that the radius of the lenticule is 0.05~0.25mm, described
The focal length of lenticule is 0.8mm, and the distance between rounded bottom surface of the adjacent lenticule is 0mm.
5. device described according to claim 1~any one of 4, which is characterized in that the host includes human-computer interaction list
Member, Decision Control unit, light source driving units and atomization generating unit, the man-machine interaction unit, the light source driving units
It is connect respectively with the Decision Control unit with the atomization generating unit, list occurs for the Decision Control unit and the atomization
Member is also connect with the atomized spray mechanism respectively.
6. device according to claim 5, which is characterized in that the atomization generating unit includes ultrasonic atomizatio room, liquid
Container, air supplying part, heating part, oxygen portion processed, solenoid valve, ozone generating unit and output interface, the liquid container and the air-supply
Portion is respectively arranged above and below the ultrasonic atomizatio room, and the ultrasonic atomizatio room is connected by pipeline and the heating part
It connects, the oxygen portion processed is connected by pipeline with the solenoid valve, and the heating part and the solenoid valve pass through pipeline through three respectively
Pass joint is connect with the output interface, and the output interface is also connect with the atomized spray mechanism；The ozone generating unit
The solenoid valve is arranged in connect on the pipeline of the three-way connection.
7. device described according to claim 1~any one of 4, which is characterized in that the atomized spray mechanism includes spray
Mist pipe, water collector and micro pump, the side of the injection spray pipe are provided with into water and connect mouth, and the side of the water collector is provided with row
Water connects mouth, and the micro pump passes through that drainpipe connects mouth with the water inlet and the draining connects mouth and connect respectively；The water collector
Be set on the lower end of the injection spray pipe, the water collector includes lower cover and upper end cover, be provided on the lower cover to
The horn-like boss that the upper end cover direction extends, the periphery of the boss is provided with multiple U-type grooves, so that in the injection spray pipe
Condensed water on wall is entered in the water collector by the U-type groove.
8. a kind of smooth power and ultrasonic atomizatio combination therapy method, which is characterized in that the described method includes:
Host determines treatment time and irradiation distance, and according to the light of input sequence irradiation mode according to the illumination parameter of input
Corresponding light source control signal is exported, so that the irradiator meets the light sequence spoke according to light source control signal generation
According to the parallel collimation and the uniform exposure light of hot spot of at least one different peak wavelengths of mode, and pressed under the irradiation distance
It is irradiated according to treatment region of the treatment time to patient；The illumination parameter includes the peak of at least one exposure light
The light energy density and illumination power density of value wavelength and the exposure light to match with the treatment region of patient；
The host prepares and exports the mist particle water containing oxygen, so that atomized spray mechanism is in the irradiator to quilt
During the treatment region of curer is irradiated, the mist particle water is sprayed to the treatment region of patient.
9. according to the method described in claim 8, it is characterized in that, light sequence irradiation mode includes the sequence irradiation of the first light
Mode, the second light sequence irradiation mode and third light sequence irradiation mode；
The first light sequence irradiation mode is that a kind of exposure light of peak wavelength repeats the treatment region of patient
Continuous or segmentation irradiation, until stopping when reaching its preset light energy density；
The second light sequence irradiation mode is the exposure light treatment to patient simultaneously of at least two different peak wavelengths
Region carries out duplicate continuous or segmentation irradiation, stops shining when one of exposure light reaches its preset light energy density
It penetrates, remaining exposure light continues to be irradiated the treatment region of patient, until all exposure lights reach its preset light
Stop irradiation when according to energy density；
The third light sequence irradiation mode is the exposure light cycle alternation of at least two different peak wavelengths to patient
Treatment region carries out duplicate continuous or segmentation irradiation, stops when one of exposure light reaches its preset light energy density
It only irradiates, remaining exposure light continues to be irradiated the treatment region of patient, presets until all exposure lights reach it
Light energy density when stop irradiation.
10. according to the method described in claim 8, it is characterized in that, the step of determining irradiation distance according to the illumination parameter
Include:
Establish distance-illumination saturation effect database of the exposure light, the distance-illumination saturation effect data
Library is used to indicate the exposure light and illumination power density average value of the target target surface under different distance；
Based on the distance-illumination saturation effect database, using linear interpolation method according to institute in the illumination parameter
The illumination power density for stating exposure light determines the irradiation distance.
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| CN201811568424.2A CN109675202B (en) | 2018-12-20 | 2018-12-20 | Photodynamic and ultrasonic atomization composite treatment device and treatment method |
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| CN109675202B (en) | 2024-05-17 |
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