CN109528531A - A kind of composition for tooth whitening and the oral care product comprising the composition - Google Patents
A kind of composition for tooth whitening and the oral care product comprising the composition Download PDFInfo
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- CN109528531A CN109528531A CN201910049121.8A CN201910049121A CN109528531A CN 109528531 A CN109528531 A CN 109528531A CN 201910049121 A CN201910049121 A CN 201910049121A CN 109528531 A CN109528531 A CN 109528531A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/29—Titanium; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
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Abstract
The present invention relates to a kind of composition for tooth whitening and the oral care products comprising the composition, belong to oral care product technical field.To solve the problems, such as that existing tooth whitening mode can cause centainly to damage to tooth and oral cavity tissue, the present invention provides a kind of composition for tooth whitening, the component including following parts by weight: 10~30 parts of photocatalyst, 0.1~10 part of thymol and 10~30 parts of solvent.Simultaneously, the present invention also provides the oral care products containing the composition for tooth whitening, photocatalysis can be played under visible light to tooth-whitening, the oxidation disinfection effect having, it can be with the organic bonding layer between oxidation removal tartar and tooth, to effectively remove the obstinate tartar such as calculus dentalis；With this, the oral care product does not injure enamel simultaneously, can also reduce dentinal tubule permeability by thymol, eliminate dentine hypersensitivity, is more suitable for the fragile crowd of sensitivity that enamel sustains damage.
Description
Technical field
The invention belongs to oral care product technical field more particularly to a kind of composition for tooth whitening and comprising
The oral care product of the composition.
Background technique
With the continuous improvement of living standards, people increasingly pay attention to dental prosthetics, not only for the de-etiolation of general tooth
Whitening more requires to go stain whitening to including obstinate cigarette stain, color spot and calculus dentalis.
Currently used tooth whitening mode is broadly divided into two classes, i.e., using mechanical or ultrasonic wave toothwash physics mode and
Use the chemical mode of peroxide bleaching tooth.The shortcomings that physics mode is the effect for only serving cleaning tooth, is used for a long time
Enamel can be made thinning, dentine is damaged；And the whitening of physics mode is usually required in hospital or dentist's office by special
Industry personnel operate, time-consuming and laborious.The shortcomings that chemical mode is with irritation and corrosivity, and peroxide is to tooth and week
It encloses group and is woven with stronger stimulation, the stimulation of aching that can cause tooth and gum is used for a long time, or even cause oral cavity tissue
Chemical burn, and chemical whitening the stupid stain on tooth is not achieved the effect of decoloration whitening.
Since existing physics whitening mode and chemical whitening mode can all cause certain damage to tooth and oral cavity tissue
Wound, therefore for crowd fragile for the sensitivity sustained damage with calculus dentalis or enamel and be not suitable for.
Summary of the invention
To solve the problems, such as that existing tooth whitening mode can cause centainly to damage to tooth and oral cavity tissue, the present invention is provided
A kind of composition for tooth whitening and the oral care product comprising the composition.
Technical solution of the present invention:
A kind of composition for tooth whitening, the component including following parts by weight:
10~30 parts of photocatalyst, 0.1~10 part of thymol and 10~30 parts of solvent.
Further, the photocatalyst is anatase crystal nano titanium dioxide powder or rutile ore crystal type nano dioxy
Change titanium powder, the partial size of the titania powder is 5~50nm, and the solvent is glycerol, propylene glycol, sorbierite, poly- second two
The combination of one or more of alcohol 200, Liquid Macrogol, polyethylene glycol 400, Macrogol 600 or cetomacrogol 1000.
A kind of oral care product comprising the composition for tooth whitening, the oral care product are toothpaste, packet
Include the component of following parts by weight: 10~30 parts of photocatalyst, 0.1~10 part of thymol, 20~85 parts of solvent, rubbing agent 5~25
Part, 0.5~5 part of foaming agent, 0.1~1 part of thickener and 0.1~1 part of colorant.
Further, the photocatalyst is anatase crystal nano titanium dioxide powder or rutile ore crystal type nano dioxy
Change titanium powder, the partial size of the titania powder is 5~50nm；The solvent is glycerol, propylene glycol, sorbierite, poly- second two
The combination of one or more of alcohol 200, Liquid Macrogol, polyethylene glycol 400, Macrogol 600 or cetomacrogol 1000；
The rubbing agent is calcium carbonate, calcium monohydrogen phosphate, calcium pyrophosphate, tricalcium phosphate, alumina silicate, aluminium hydroxide, aluminium oxide, zeolite, silicon
The combination of one or more of sour or kaolin；The foaming agent is in lauryl sodium sulfate or dodecanoyl musculamine acid sodium
One or two kinds of combinations；The thickener is carbomer, xanthan gum, modified guar, carragheen, methylcellulose, carboxylic
The combination of one or more of methylcellulose, sodium carboxymethylcellulose, hydroxyethyl cellulose or hydroxypropyl methyl cellulose；
The colorant is non-nano grade titanium dioxide or natural pigment.
A kind of oral care product comprising the composition for tooth whitening, the oral care product are solidifying for tooth
Glue, the component including following parts by weight: 10~30 parts of photocatalyst, 0.1~10 part of thymol, 40~85 parts of solvent, thickener 5
~15 parts, 0.5~2 part of preservative and 1~2 part of bleeding agent.
Further, the photocatalyst is anatase crystal nano titanium dioxide powder or rutile ore crystal type nano dioxy
Change titanium powder, the partial size of the titania powder is 5~50nm；The solvent is glycerol, propylene glycol, ethyl alcohol, sorbierite, gathers
The group of one or more of ethylene glycol 200, Liquid Macrogol, polyethylene glycol 400, Macrogol 600 or cetomacrogol 1000
It closes；The thickener is in sodium carboxymethylcellulose, hypromellose, polyvinylpyrrolidone, gelatin or carbomer
One or more of combinations；The preservative is one in parabens, benzoic acid, sodium benzoate, sorbic acid or benzalkonium bromide
Kind or several combinations；The bleeding agent is azone, dimethyl sulfoxide, saliva ketone, azone, peppermint oil, borneol, eucalyptus oil or turpentine
The combination of one or more of oil.
A kind of oral care product comprising the composition for tooth whitening, the oral care product are tooth patch, packet
Include the component of following parts by weight: 10~30 parts of photocatalyst, 0.1~10 part of thymol, 10~30 parts of solvent, thickener 20~50
Part and 20~30 parts of film forming agent.
Further, the photocatalyst is anatase crystal nano titanium dioxide powder or rutile ore crystal type nano dioxy
Change titanium powder, the partial size of the titania powder is 5~50nm；The solvent is glycerol, propylene glycol, sorbierite, poly- second two
The combination of one or more of alcohol 200, Liquid Macrogol, polyethylene glycol 400, Macrogol 600 or cetomacrogol 1000；
The thickener is the combination of one or more of sodium carboxymethylcellulose, hypromellose, gelatin or carbomer；Institute
State the combination that film forming agent is one or more of polyvinyl alcohol, polyvinylpyrrolidone or acrylic resin.
Beneficial effects of the present invention:
Hydroxyl free is generated in photo-oxidation process provided by the present invention for the photocatalyst in the composition of tooth whitening
Base can aoxidize various organic matters, and the chemical bond cutting that can will constitute organic molecule is decomposed, and the higher photocatalyst of ratio can be with
The stains such as dental calculus are effectively eliminated, thus tooth-whitening, and during entire whitening damage is not generated to former tooth.
Thymol, disinfecting power is strong, and efficiency of preservation is big, and irritation is small, can infiltrate into dentinal tubule, through dentine
Tubule forms crystallization, blocks Dentinal tubules, reduces dentinal tubule permeability, eliminates dentine hypersensitivity；It is touched with light
Matchmaker's double action can promote remineralization of teeth while tooth-whitening.
Simple provided by the present invention for the composition preparation process of tooth whitening, processing cost is low, implementation easy to spread,
Can be widely applied to the various oral care products of tooth-whitening, including toothpaste, denfifrice, tooth powder, gargle, gel, dental floss,
Chewing gum, tooth patch, whitening tooth pen and effervescent tablet etc..
Oral care product provided by the invention containing the composition for tooth whitening, can play under visible light
Photocatalysis is to tooth-whitening, the oxidation disinfection effect having, can be viscous with the organic matter between oxidation removal tartar and tooth
Layer is connect, to effectively remove the obstinate tartar such as calculus dentalis；With this, oral care product provided by the invention does not injure tooth enamel simultaneously
Matter can also reduce dentinal tubule permeability by thymol, eliminate dentine hypersensitivity, be more suitable for enamel and damaged
The fragile crowd of harmful sensitivity.
Detailed description of the invention
Fig. 1 is after tested tooth impregnates the composition that embodiment 5 provides, to stay in the yellow particle shape insoluble matter in facing
Photo；
Fig. 2 is the effect contrast figure that dental calculus is eliminated before and after impregnating the composition that provides of embodiment 5, before upper figure be immersion, under
Figure is after impregnating；
Fig. 3 is the electron microscope brushed the composition predentin surface that embodiment 2 provides and amplify 2000 times；
Fig. 4 is the electron microscope that dentin surface amplifies 2500 times after brushing the composition that embodiment 2 provides；
Fig. 5 is to brush whitening effect comparison diagram before and after the toothpaste that embodiment 8 provides；
Fig. 6 is to impregnate whitening effect comparison diagram before and after the tooth gel that embodiment 11 provides；
Fig. 7 is the tooth patch front and back whitening effect comparison diagram pasting embodiment 15 and providing.
Specific embodiment
Below with reference to embodiment, the following further describes the technical solution of the present invention, and however, it is not limited to this, all right
Technical solution of the present invention is modified or replaced equivalently, and without departing from the spirit and scope of the technical solution of the present invention, should all be contained
Lid is within the protection scope of the present invention.
Embodiment 1
A kind of composition for tooth whitening, the component including following parts by weight:
10~30 parts of photocatalyst, 0.1~10 part of thymol and 10~30 parts of solvent.
In the present embodiment, the photocatalyst is anatase crystal nano titanium dioxide powder or rutile ore crystal type nano two
Titanium dioxide powder, the partial size of the titania powder are 5~50nm, and the solvent is glycerol, propylene glycol, sorbierite, poly- second
The group of one or more of glycol 200, Liquid Macrogol, polyethylene glycol 400, Macrogol 600 or cetomacrogol 1000
It closes.The preparation method of composition is that photocatalyst and thymol are added in solvent to stir evenly in the present embodiment.
Embodiment 2
A kind of composition for tooth whitening, the component including following parts by weight:
10 parts of anatase crystal nano titanium dioxide powder, 5 parts of thymol and 25 parts of glycerol.
Embodiment 3
A kind of composition for tooth whitening, the component including following parts by weight:
30 parts of anatase crystal nano titanium dioxide powder, 10 parts of thymol and 30 parts of glycerol.
Embodiment 4
A kind of composition for tooth whitening, the component including following parts by weight:
10 parts of anatase crystal nano titanium dioxide powder, 0.2 part of thymol and 20 parts of glycerol.
Embodiment 5
A kind of composition for tooth whitening, the component including following parts by weight:
30 parts of anatase crystal nano titanium dioxide powder, 5 parts of thymol and 10 parts of glycerol.
The preparation method for the composition that embodiment 2- embodiment 5 provides be by anatase crystal nano titanium dioxide powder and
Thymol is added in glycerol and stirs evenly.
Embodiment 6
Present embodiments provide a kind of oral care product comprising the composition for tooth whitening, the oral care
Product is toothpaste, the component including following parts by weight: 10~30 parts of photocatalyst, 0.1~10 part of thymol, solvent 20~85
Part, 5~25 parts of rubbing agent, 0.5~5 part of foaming agent, 0.1~1 part of thickener and 0.1~1 part of colorant.
Photocatalyst described in the present embodiment is anatase crystal nano titanium dioxide powder or rutile ore crystal type nano dioxy
Change titanium powder, the partial size of the titania powder is 5~50nm；The solvent is glycerol, propylene glycol, sorbierite, poly- second two
The combination of one or more of alcohol 200, Liquid Macrogol, polyethylene glycol 400, Macrogol 600 or cetomacrogol 1000；
Solvent described in the present embodiment plays the role of moisturizer simultaneously；The rubbing agent be calcium carbonate, calcium monohydrogen phosphate, calcium pyrophosphate,
The combination of one or more of tricalcium phosphate, alumina silicate, aluminium hydroxide, aluminium oxide, zeolite, silicic acid or kaolin；The hair
Infusion is the combination of one or both of lauryl sodium sulfate or dodecanoyl musculamine acid sodium；The thickener is card wave
Nurse, xanthan gum, modified guar, carragheen, methylcellulose, carboxymethyl cellulose, sodium carboxymethylcellulose, hydroxy ethyl fiber
The combination of one or more of plain or hydroxypropyl methyl cellulose；The colorant is non-nano grade titanium dioxide or natural colour
Element.
Steps are as follows for the preparation method of toothpaste provided in this embodiment:
Each raw material is weighed by formulation of tooth-paste, solvent is added in preparing tank, thickener is added by several times and stirs homogeneous, is stirred
While be heated to 40~60 DEG C, one third rubbing agent is added and stirs, sequentially add foaming agent, colorant,
Remaining 2/3rds rubbing agent is added by several times after mixing evenly and homogeneous, stopping heating being taken out true by photocatalyst, thymol
Sky is stirred until homogeneous, degassing, after standing it is filling to get.
Embodiment 7
Present embodiments provide a kind of oral care product comprising the composition for tooth whitening, the oral care
Product is toothpaste, the component including following parts by weight: 10 parts of anatase crystal nano titanium dioxide powder, 5 parts of thymol, sweet
42 parts of oil, 10 parts of propylene glycol, 20 parts of calcium carbonate, 1 part of lauryl sodium sulfate, 1 part of carbomer and non-nano grade titanium dioxide 1
Part, the partial size of titania powder is 5~50nm in the present embodiment.
Embodiment 8
Present embodiments provide a kind of oral care product comprising the composition for tooth whitening, the oral care
Product is toothpaste, the component including following parts by weight: 15 parts of rutile ore crystal type nano TiO 2 powder, thymol 10
Part, 34 parts of glycerol, 5.2 parts of polyethylene glycol 400,5 parts of calcium monohydrogen phosphate, 0.5 part of dodecanoyl musculamine acid sodium, carboxymethyl cellulose
0.2 part and 0.4 part of non-nano grade titanium dioxide, the partial size of titania powder is 5~50nm in the present embodiment.
Embodiment 9
Present embodiments provide a kind of oral care product comprising the composition for tooth whitening, the oral care
Product is tooth gel, the component including following parts by weight: 10~30 parts of photocatalyst, 0.1~10 part of thymol, solvent 40~
85 parts, 5~15 parts of thickener, 0.5~2 part of preservative and 1~2 part of bleeding agent.
Photocatalyst described in the present embodiment is anatase crystal nano titanium dioxide powder or rutile ore crystal type nano two
Titanium dioxide powder, the partial size of the titania powder are 5~50nm；The solvent be glycerol, propylene glycol, ethyl alcohol, sorbierite,
One or more of polyethylene glycol 200, Liquid Macrogol, polyethylene glycol 400, Macrogol 600 or cetomacrogol 1000
Combination, solvent described in the present embodiment play the role of moisturizer simultaneously；The thickener is sodium carboxymethylcellulose, hydroxypropyl first
The combination of one or more of base cellulose, polyvinylpyrrolidone, gelatin or carbomer；The preservative is nipalgin
The combination of one or more of class, benzoic acid, sodium benzoate, sorbic acid or benzalkonium bromide；The bleeding agent is azone, diformazan
The combination of one or more of sulfoxide, saliva ketone, azone, peppermint oil, borneol, eucalyptus oil or turpentine oil.
Steps are as follows for the preparation method of tooth gel provided in this embodiment:
1) will be pre-dispersed in thickener investment one third solvent, it stirs evenly, obtains feed liquid A；
2) by photocatalyst, thymol, 2/3rds solvents of investment, sufficiently dissolution is stirred, feed liquid B is obtained；
3) feed liquid B is transferred in feed liquid A, is stirred until homogeneous；
4) preservative and bleeding agent are slowly put into mixed liquor, vacuum stirring to uniform, degassing, it is filling after standing, i.e.,
?.
Embodiment 10
Present embodiments provide a kind of oral care product comprising the composition for tooth whitening, the oral care
Product is tooth gel, the component including following parts by weight: 15 parts of anatase crystal nano titanium dioxide powder, thymol 10
Part, 20 parts of glycerol, 20 parts of propylene glycol, 18 parts of ethyl alcohol, 10 parts of carbomer, 1 part of ethylparaben and 1 part of azone.
Embodiment 11
Present embodiments provide a kind of oral care product comprising the composition for tooth whitening, the oral care
Product is tooth gel, the component including following parts by weight: 25 parts of anatase crystal nano titanium dioxide powder, thymol 5
Part, 20 parts of glycerol, 10 parts of propylene glycol, 17 parts of ethyl alcohol, 15 parts of carbomer, 1 part of ethylparaben and 2 parts of azone.
Embodiment 12
Present embodiments provide a kind of oral care product comprising the composition for tooth whitening, the oral care
Product is tooth gel, the component including following parts by weight: 25 parts of rutile ore crystal type nano TiO 2 powder, thymol
8 parts, 20 parts of glycerol, 15 parts of sorbierite, 15 parts of polyethylene glycol 400,12 parts of gelatin, 1.5 parts of sorbic acid and 1.5 parts of dimethyl sulfoxide.
Embodiment 13
Present embodiments provide a kind of oral care product comprising the composition for tooth whitening, the oral care
Product is tooth patch, the component including following parts by weight: 10~30 parts of photocatalyst, 0.1~10 part of thymol, solvent 10~30
Part, 20~50 parts of thickener and 20~30 parts of film forming agent.
Photocatalyst described in the present embodiment is anatase crystal nano titanium dioxide powder or rutile ore crystal type nano two
Titanium dioxide powder, the partial size of the titania powder are 5~50nm；The solvent is glycerol, propylene glycol, sorbierite, poly- second
The group of one or more of glycol 200, Liquid Macrogol, polyethylene glycol 400, Macrogol 600 or cetomacrogol 1000
It closes, solvent described in the present embodiment plays the role of moisturizer simultaneously；The thickener is sodium carboxymethylcellulose, hydroxypropyl
The combination of one or more of cellulose, gelatin or carbomer；The film forming agent be polyvinyl alcohol, polyvinylpyrrolidone or
The combination of one or more of acrylic resin.
Steps are as follows for the preparation method of tooth patch provided in this embodiment:
Each raw material is weighed by tooth plaster formula, solvent is added in preparing tank, thickener is added by several times and stirs homogeneous, is stirred
While be heated to 40~60 DEG C, sequentially add film forming agent, photocatalyst, thymol and homogeneous, stop heating, vacuumize and stir
It mixes to uniform, gained viscoloid passes through coating again, cutting, impression, receives the continuous processings such as useless, cutting and directly prepare whitening tooth
Patch.
Embodiment 14
Present embodiments provide a kind of oral care product comprising the composition for tooth whitening, the oral care
Product is tooth patch, the component including following parts by weight: 10 parts of anatase crystal nano titanium dioxide powder, 2 parts of thymol, sweet
Oily 24 parts, 15 parts of sodium carboxymethylcellulose, 2 parts of hypromellose, 10 parts of polyvinylpyrrolidone, 10 parts of gelatin, card wave
4 parts of nurse, 18 parts of polyvinyl alcohol.
Embodiment 15
Present embodiments provide a kind of oral care product comprising the composition for tooth whitening, the oral care
Product is tooth patch, the component including following parts by weight: 25 parts of anatase crystal nano titanium dioxide powder, 2 parts of thymol, sweet
Oily 27 parts, 20 parts of sodium carboxymethylcellulose, 2 parts of hypromellose, 12 parts of polyvinylpyrrolidone, 12 parts of gelatin, card wave
5 parts of nurse, 10 parts of polyvinyl alcohol.
The whitening effect for the composition for tooth whitening for examining embodiment 2-5 to provide:
The method of inspection: according to International Commission on Illumination (InternationalCommittee ofIllumination,
CIE) the canonical measure HunterLab value formulated, the numerical value that Lab system provides three-dimensional color space indicate that wherein L indicates brightness
Axis, a indicate that red-green axis, b indicate yellow-blue axis.Usual L axis and b axis are best suited for the measurement of tooth whiteness.L value is bigger, and b value is got over
Small, tooth is whiter.Difference is indicated with △ L (L using-L after gel using gel before) before and after L value；Difference △ b before and after b value
(b using-b after gel using gel before) is indicated.
Experiment one:
1, any surface finish is chosen in experiment, and the bad baurodont of no dental caries is cut into the tooth enamel mass of 8mm × 8mm, with identical dyeing side
Case obtains the bovine-enamel block of fresh dyeing, and the Lab value of dyeing baurodont, the tooth enamel for taking 15 pieces of Lab values uniform are tested with color difference meter
Mass is uniformly divided into 5 groups at random；
2, the composition and pure glycerin for taking 0.5g embodiment 2-5 to prepare respectively, are uniformly applied to tooth enamel mass, 2 is small respectively
When after measure Lab value, calculate front and back L value difference；Experiment in triplicate, calculates the average value of every group of Δ L；It is recorded in table 1；
Table 1
| The variation of L value | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 | Glycerol |
| ΔL | 10.61 | 20.46 | 14.55 | 32.15 | 3.23 |
The composition that it can be seen from data in table 1 prepared by embodiment 2-5 has the effect of apparent tooth-whitening.
Experiment two:
1, random selection because often drinking coffee, subject 5 that tea, red wine or smoking due to make tooth turn to be yellow in various degree, use
Color difference meter tests the Lab value of upper 2, front tooth；
2, the composition and pure glycerin for taking 1.0g embodiment 2-5 to prepare respectively, are placed in facing, subject with upper shell,
Upper front tooth is immersed in solution 2 hours, with 10s is rinsed in deionized water, Lab value is measured, calculates the L value difference of front and back；It calculates
The average value of every group of Δ L；It is recorded in table 2；
Table 2
| The variation of L value | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 | Glycerol |
| ΔL | 11.23 | 21.32 | 15.27 | 33.48 | 4.71 |
The composition that it can be seen from data in table 2 prepared by embodiment 2-5 becomes apparent from the whitening effect of tooth.
With the presence of yellow particle shape insoluble matter in the facing that the composition that is provided using embodiment 2-5 impregnates tooth,
Fig. 1 is after tested tooth impregnates the composition that embodiment 5 provides, to stay in the photo of the yellow particle shape insoluble matter in facing；Phase
The dental calculus for the tested tooth answered is reduced, and reduces that degree photocatalyst concentration is directly proportional, this shows that high concentration photocatalyst can be with
Effectively eliminate dental calculus.Fig. 2 is the effect contrast figure that dental calculus is eliminated before and after impregnating the composition that embodiment 5 provides, and upper figure is leaching
Before bubble, the following figure is after impregnating；From the comparison of Fig. 1 and Fig. 2 as can be seen that the combination for tooth whitening that embodiment 2-5 is provided
Object can effectively eliminate the stains such as dental calculus while tooth-whitening.
The antiallergic effect for the composition for tooth whitening for examining embodiment 2 to provide:
The method of inspection: prepare the Isolated Tooth for impregnating 12h in artificial saliva, brushed with the composition that embodiment 2 provides
5min, manually saliva is rinsed, is dried.Dentin surface's mineralized layer formational situation is observed by SEM, as a result such as Fig. 3 and Fig. 4 institute
Show；
Fig. 3 is the electron microscope brushed the composition predentin surface that embodiment 2 provides and amplify 2000 times；Fig. 4 is to brush
2500 times of electron microscope is amplified by dentin surface after the composition that embodiment 2 provides.Comparison from Fig. 3 and Fig. 4 picture can
Out, after brushing the composition that embodiment 2 provides, thymol forms crystallization through dentinal tubule, makes Dentinal tubules
Blocking, exposed canaliculi dentales are all closed substantially.After canaliculi dentales are closed as can be seen from Figure 4, the tooth of demineralization is realized again
Mineralising, originally exposed canaliculi dentales are closed, to prevent extraneous by stimulation of the dentinal tubule to Intradental nerve.
It follows that the thymol in composition provided by the invention makes tooth to form crystallization through dentinal tubule
Tubules opening blocking, reduces dentinal tubule permeability, eliminates dentine hypersensitivity.Thymol i.e. in composition overcomes
Photocatalyst side effect caused by tooth, can repair rapidly photocatalyst damage caused by dentine during whitening, real
Existing antianaphylactic effect.
The whitening effect for the toothpaste comprising the composition for tooth whitening for examining embodiment 7,8 to provide:
Experiment one:
1, any surface finish is chosen in experiment, and the bad baurodont of no dental caries is cut into the tooth enamel mass of 8mm × 8mm, with identical dyeing side
Case obtains the bovine-enamel block of fresh dyeing, and the Lab value of dyeing baurodont, the enamel for taking 6 pieces of Lab values uniform are tested with color difference meter
Block is uniformly divided into 2 groups at random, is fixed on simulation Tooth-brushing device；
2,4 embodiment of 1g table, 7,8 gained toothpaste is taken respectively, is adsorbed in the sea of same specification (1.5cm × 1.5cm × 1.5cm)
Silk floss replaces removing tooth enamel mass under toothbrush brush baurodont 100,10s being rinsed in 10ml deionized water, and use color respectively with sponge
The Lab value of poor instrument test dyeing baurodont, calculates the L value difference of front and back, calculates every group of Δ L average value, be recorded in table 3；
Table 3
| The variation of L value | Embodiment 7 | Embodiment 8 |
| ΔL | 8.33 | 16.45 |
By table 3 statistics indicate that the offer of embodiment 7,8 includes the beauty for being used for the toothpaste of the composition of tooth whitening to tooth
White effect is more obvious.
Experiment two: quick whitening effect verification test:
It randomly chooses because often drinking coffee, the subject that tea, red wine or smoking due to make tooth turn to be yellow in various degree, sooner or later each one
The secondary toothpaste provided using embodiment 8 is brushed teeth, and two minutes every time；Compared after 20 days with 16 colour standard colorimetric cards, subject's tooth
Tooth brightens 1~2 color number, and Fig. 5 is to brush whitening effect comparison diagram before and after the toothpaste that embodiment 8 provides, can from figure
Out, toothpaste provided by the invention can fast implement whitening, and significant effect.After six weeks, subject is looked for again without any mouth
Chamber is uncomfortable, and tooth is to cold and hot stimulation also without sensitive ache phenomenon.
The whitening effect for the tooth gel comprising the composition for tooth whitening for examining embodiment 10,11,12 to provide:
Experiment one:
1, any surface finish is chosen in experiment, and the bad baurodont of no dental caries is cut into the tooth enamel mass of 8mm × 8mm, with identical dyeing side
Case obtains the bovine-enamel block of fresh dyeing, and the Lab value of dyeing baurodont, the enamel for taking 9 pieces of Lab values uniform are tested with color difference meter
Block is uniformly divided into 3 groups at random；
2,6 embodiment of 1g table, 10,11,12 gained gel is taken respectively, and dyeing baurodont is immersed in gel 2 hours, is removed
Tooth enamel mass rinses 10s in 10ml deionized water, and tests the Lab value of dyeing baurodont with color difference meter respectively, calculates front and back
L value difference calculates every group of Δ L average value, is recorded in table 4；
Table 4
| The variation of L value | Embodiment 10 | Embodiment 11 | Embodiment 12 |
| ΔL | 12.22 | 18.64 | 17.55 |
By table 4 statistics indicate that the tooth gel pair comprising the composition for tooth whitening that embodiment 10,11,12 provides
The whitening effect of tooth is more obvious.
Experiment two:
Quick whitening effect verification test:
It randomly chooses because often drinking coffee, the subject that tea, red wine or smoking due to make tooth turn to be yellow in various degree, uses implementation
The tooth gel that example 11 provides, upper front tooth is immersed in gel after 2 hours, is compared with 16 colour standard colorimetric cards, subject's tooth
Tooth brightens 1~2 color number, and Fig. 6 is to impregnate whitening effect comparison diagram before and after the tooth gel that embodiment 11 provides, can from figure
To find out, tooth gel provided by the invention can fast implement whitening, significant effect.And subject is uncomfortable without any oral cavity,
Tooth is to cold and hot stimulation also without sensitive ache phenomenon.
The whitening effect for the tooth patch comprising the composition for tooth whitening for examining embodiment 14,15 to provide:
Experiment one:
1, any surface finish is chosen in experiment, and the bad baurodont of no dental caries is cut into the tooth enamel mass of 8mm × 8mm, with identical dyeing side
Case obtains the bovine-enamel block of fresh dyeing, and the Lab value of dyeing baurodont, the enamel for taking 6 pieces of Lab values uniform are tested with color difference meter
Fastly, uniformly it is divided into 2 groups at random；
2,8 embodiment 14 of 1g table, 15 gained teeth patch are taken respectively, and tooth is attached on dyeing baurodont 2 hours, enamel is removed
Block rinses 10s in 10ml deionized water, and tests the Lab value of dyeing baurodont with color difference meter respectively, calculates the L value difference of front and back,
Every group of Δ L average value is calculated, table 5 is recorded in；
Table 5
| The variation of L value | Embodiment 14 | Embodiment 15 |
| ΔL | 8.72 | 13.69 |
By table 5 statistics indicate that the tooth comprising the composition for tooth whitening that embodiment 14,15 provides is pasted to tooth
Whitening effect is more obvious.
Experiment two: quick whitening effect verification test:
It randomly chooses because often drinking coffee, the subject that tea, red wine or smoking due to make tooth turn to be yellow in various degree, uses implementation
The tooth tooth patch that example 14 provides, tooth is affixed on upper front tooth after 4 hours, is compared with 16 colour standard colorimetric cards, subject's tooth
1~2 color number is brightened, Fig. 7 is the tooth patch front and back whitening effect comparison diagram pasting embodiment 15 and providing, can from figure
Out, tooth tooth patch provided by the invention can fast implement whitening, significant effect.And subject is uncomfortable without any oral cavity, tooth
To cold and hot stimulation also without sensitive ache phenomenon.
Claims (8)
1. a kind of composition for tooth whitening, which is characterized in that the component including following parts by weight:
10~30 parts of photocatalyst, 0.1~10 part of thymol and 10~30 parts of solvent.
2. a kind of composition for tooth whitening according to claim 1, which is characterized in that the photocatalyst is anatase
Crystal type nano TiO 2 powder or rutile ore crystal type nano TiO 2 powder, the partial size of the titania powder are 5
~50nm, the solvent are glycerol, propylene glycol, sorbierite, polyethylene glycol 200, Liquid Macrogol, polyethylene glycol 400, poly- second
The combination of one or more of glycol 600 or cetomacrogol 1000.
3. a kind of oral care product comprising the composition for tooth whitening, which is characterized in that including following parts by weight
Component: 10~30 parts of photocatalyst, 0.1~10 part of thymol, 20~85 parts of solvent, 5~25 parts of rubbing agent, foaming agent 0.5~5
Part, 0.1~1 part of thickener and 0.1~1 part of colorant.
4. a kind of oral care product comprising the composition for tooth whitening according to claim 3, which is characterized in that
The photocatalyst is anatase crystal nano titanium dioxide powder or rutile ore crystal type nano TiO 2 powder, the dioxy
The partial size for changing titanium powder is 5~50nm；The solvent be glycerol, propylene glycol, sorbierite, polyethylene glycol 200, Liquid Macrogol,
The combination of one or more of polyethylene glycol 400, Macrogol 600 or cetomacrogol 1000；The rubbing agent be calcium carbonate,
One of calcium monohydrogen phosphate, calcium pyrophosphate, tricalcium phosphate, alumina silicate, aluminium hydroxide, aluminium oxide, zeolite, silicic acid or kaolin or
Several combinations；The foaming agent is the combination of one or both of lauryl sodium sulfate or dodecanoyl musculamine acid sodium；
The thickener is carbomer, xanthan gum, modified guar, carragheen, methylcellulose, carboxymethyl cellulose, carboxymethyl fibre
Tie up the combination of one or more of plain sodium, hydroxyethyl cellulose or hydroxypropyl methyl cellulose；The colorant is non-nano
Grade titanium dioxide or natural pigment.
5. a kind of oral care product comprising the composition for tooth whitening, which is characterized in that including following parts by weight
Component: 10~30 parts of photocatalyst, 0.1~10 part of thymol, 40~85 parts of solvent, 5~15 parts of thickener, preservative 0.5~2
Part and 1~2 part of bleeding agent.
6. a kind of oral care product comprising the composition for tooth whitening according to claim 5, which is characterized in that
The photocatalyst is anatase crystal nano titanium dioxide powder or rutile ore crystal type nano TiO 2 powder, the dioxy
The partial size for changing titanium powder is 5~50nm；The solvent is glycerol, propylene glycol, ethyl alcohol, sorbierite, polyethylene glycol 200, poly- second two
The combination of one or more of alcohol 300, polyethylene glycol 400, Macrogol 600 or cetomacrogol 1000；The thickener is
The group of one or more of sodium carboxymethylcellulose, hypromellose, polyvinylpyrrolidone, gelatin or carbomer
It closes；The preservative is the combination of one or more of parabens, benzoic acid, sodium benzoate, sorbic acid or benzalkonium bromide；
The bleeding agent is one of azone, dimethyl sulfoxide, saliva ketone, azone, peppermint oil, borneol, eucalyptus oil or turpentine oil or several
The combination of kind.
7. a kind of oral care product comprising the composition for tooth whitening, which is characterized in that including following parts by weight
Component: 10~30 parts of photocatalyst, 0.1~10 part of thymol, 10~30 parts of solvent, 20~50 parts of thickener and film forming agent 20~
30 parts.
8. a kind of oral care product comprising the composition for tooth whitening according to claim 7, which is characterized in that
The photocatalyst is anatase crystal nano titanium dioxide powder or rutile ore crystal type nano TiO 2 powder, the dioxy
The partial size for changing titanium powder is 5~50nm；The solvent be glycerol, propylene glycol, sorbierite, polyethylene glycol 200, Liquid Macrogol,
The combination of one or more of polyethylene glycol 400, Macrogol 600 or cetomacrogol 1000；The thickener is carboxymethyl
The combination of one or more of sodium cellulosate, hypromellose, gelatin or carbomer；The film forming agent is polyethylene
The combination of one or more of alcohol, polyvinylpyrrolidone or acrylic resin.
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| CN110302065A (en) * | 2019-08-19 | 2019-10-08 | 四川涑爽医疗用品有限公司 | A kind of whitening strips and its preparation process containing photocatalyst |
| CN113041163A (en) * | 2021-03-03 | 2021-06-29 | 深圳市博威凯特科技有限公司 | Composition for promoting tooth mineralization and application |
| CN114933489A (en) * | 2022-07-01 | 2022-08-23 | 杭州新致美义齿研发有限公司 | All-ceramic tooth staining solution, preparation method and application of staining solution to all-ceramic teeth |
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| CN110302065A (en) * | 2019-08-19 | 2019-10-08 | 四川涑爽医疗用品有限公司 | A kind of whitening strips and its preparation process containing photocatalyst |
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