CN109511664A - A kind of bactericidal composition for disliking bacterium azoles and cyazofamid containing dichloro - Google Patents
A kind of bactericidal composition for disliking bacterium azoles and cyazofamid containing dichloro Download PDFInfo
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- CN109511664A CN109511664A CN201710838577.3A CN201710838577A CN109511664A CN 109511664 A CN109511664 A CN 109511664A CN 201710838577 A CN201710838577 A CN 201710838577A CN 109511664 A CN109511664 A CN 109511664A
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- bactericidal composition
- cyazofamid
- bacterium azoles
- dichloro
- synergistic bactericidal
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/82—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with three ring hetero atoms
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/50—1,3-Diazoles; Hydrogenated 1,3-diazoles
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The present invention relates to a kind of Synergistic bactericidal composition for disliking bacterium azoles and cyazofamid containing dichloro, it is 1:30-30:1 that the dichloro, which dislikes bacterium azoles and the weight ratio of cyazofamid, and the weight ratio is 1:10-10:1；The weight percentage of composition shared by active constituent is 1-80%, preferably 20-50% in the Synergistic bactericidal composition, remaining is auxiliary element conventional in Pesticide formulation；Synergistic bactericidal composition of the invention is prepared into any one dosage form used in suitable agricultural production by being aided with auxiliary element, and composition pesticide compounding of the invention is reasonable, it is possible to reduce pesticide activity component usage amount improves control efficiency.
Description
Technical field
The present invention relates to a kind of bactericidal compositions and application thereof, more particularly to a kind of dichloro that contains to dislike bacterium azoles and cyanogen frost
The bactericidal composition of azoles, and its application for preventing and treating corps diseases, especially oomycetes diseases.
Background technique
The late blight of potato is caused by phytophthora infestans, a kind of destructiveness for causing potato haulm death and stem tuber to be rotted
Fungal disease, germ is mainly overwintering in potato wedge with mycelium, sows potato wedge of carrying disease germs, and causes to be unearthed after not germinateing or germinateing i.e. dead
It goes, some becomes primary infection focus after being unearthed, sick portion generates sporangium and air-flow propagation is borrowed to be infected again, forms infection center, cause
From point to surface, sprawling expands the disease rapidly, and the sporangium on sick leaf can also go deep into soil infecting potato wedge, shape with rainwater or irrigation water
At sick potato, become next year main source of infection, comes currently, the prevention and treatment late blight of potato relies primarily on chemical pesticide using but single
The long-time service of Class Chemical pesticide will lead to the generation of pathogen drug resistance, cause to increase in Pesticide use, under control efficiency
Drop.
Cyazofamid is sulphaguanidine azoles fungicide, has strong bactericidal activity to Oomycete fungal, raw to Pseudoperonospora cubensis
Each growth phase of history living include the formation of sporangium, the sprouting of sporangium, the formation of egg spore, the release of zoospore,
The movement of zoospore and the growth of mycelia all have very high inhibitory effect, and the cyazofamid mode of action is different from other sterilizations
No interactions drug resistance between agent, with other systemic fungicides；The reagent toxicity is low, has good toxicologic properties, to ecology
Environment and crop and non-target organism safety.
It is a kind of oxazole sulfone class fungicide, chemical name that dichloro, which dislikes bacterium azoles, are as follows: 2- methyl sulfuryl -5-(2,4- dichloro-benzenes
Base) -1,3,4- oxadiazoles, molecular formula C9H6O3N2C12S, dichloro dislike bacterium azoles to such as evening of the disease as caused by Oomycete pathogen
Epidemic disease, downy mildew etc. have good control efficiency.
The pesticide species that single kind is used for a long time will lead to the increase of pathogen drug resistance, control efficiency decline, and cyanogen frost
Azoles price itself is relatively expensive, higher operating costs.Present inventor is by the screening of a large amount of toxicity and field medicine
Effect test is found surprisingly that after dichloro is disliked bacterium azoles and cyazofamid compounding, Pesticide use amount and cost can be significantly reduced, mutually
Between can achieve apparent synergistic function, it is expected to as the important means of comprehensive control of disease, after further research,
The present invention is completed, currently, it is not yet found that disliking the relevant report of bacterium azoles and cyazofamid compounding about dichloro.
Summary of the invention
The purpose of the present invention is to provide a kind of compounding synergistic sterilizing combinations that bacterium azoles and cyazofamid are disliked containing dichloro
Object, the bactericidal composition control efficiency is good, and use cost is low, environmentally friendly reliable.
The association that can be overcome another object of the present invention is to provide described one kind and/or pathogen drug resistance is delayed to generate
Same Synergistic bactericidal composition.
Another object of the present invention, which also resides in, provides the bactericidal composition for preventing and treating corps diseases, especially oomycetes
The application of guiding principle disease.
In order to achieve the above object, the present invention adopts the following technical scheme:
A kind of Synergistic bactericidal composition, its active constituent include that dichloro dislikes bacterium azoles and cyazofamid, wherein dichloro dislikes bacterium azoles and cyanogen
The weight ratio of white azoles is 1:30-30:1, it is preferred that the weight ratio is 1:10-10:1.
Further, the weight percentage of composition shared by active constituent is 1-80% in the Synergistic bactericidal composition,
Preferably 20-50%, remaining is auxiliary element conventional in Pesticide formulation.
Further, the auxiliary element includes wetting agent, dispersing agent, thickener, stabilizer, defoaming agent, disintegrating agent, profit
One of humectant, filler etc. are a variety of.
Further, Synergistic bactericidal composition of the invention is prepared into suitable agricultural production by being aided with auxiliary element and is made
Any one dosage form, including but not limited to missible oil, aqueous emulsion, water dispersible granules, wettable powder, microemulsion, suspending agent,
Any one of seed treatment.
Further, Synergistic bactericidal composition of the invention can be provided in the form of finished product preparation, i.e., each object in composition
Matter has mixed, and can also be provided with independent dosage form, is directly mixed, is then diluted in the containers such as bucket, tank using preceding
Required concentration uses.
Further, Synergistic bactericidal composition of the invention can be also used in mixed way with other agricultural active ingredients, it is described its
Its agricultural active ingredient include but is not limited to the fungicide of other types, nematicide, insecticide, plant growth regulator,
One of soil conditioner, synergist, safener etc. or more than one.
Further, Synergistic bactericidal composition of the invention can be used by a variety of different methods, such as by spraying, be spread
It applies, pour.
Further, the usage amount of Synergistic bactericidal composition of the invention is with place, weather, difference of controlling object etc.,
Administration dosage would also vary from.
Compared with prior art, Synergistic bactericidal composition of the invention has the beneficial effect that
(1) after active constituent is used in compounding in Synergistic bactericidal composition of the invention, it can achieve significant synergistic function,
Pesticide activity component usage amount can be reduced, control efficiency is improved；
(2) Synergistic bactericidal composition lasting effect of the invention and quick-acting are substantially less than unit dose preparation, it is possible to reduce the applications of pesticide
Number reduces Pesticide use cost；
(3) Synergistic bactericidal composition of the invention can overcome and/or delay the generation of pathogen drug resistance.
Specific embodiment
In order to which the purpose of the present invention, technical solution and advantage is more clearly understood, with reference to embodiments, to this hair
It is bright to be described in further detail, it should be appreciated that specific embodiment described herein is used only for explaining the present invention, not
Limitation of the invention, any modifications, equivalent replacements and improvementsmade within the spirit and principles of the invention, can be considered as
Deng should all be included in the protection scope of the present invention.
One, raw to survey embodiment
1, controlling object: the late blight of potato
2, test method: dilute with the deionized water containing 0.1%Tween 80 after dichloro evil bacterium azoles and cyazofamid are dissolved with solvent
The mother liquor for being configured to 1000 ug/mL is released, is saved in 4 DEG C stand-by.
Test uses mycelial growth rate method with reference to " farm-chemical indoor determination test rule NY/T1156.2-2006 ".
On ultra-clean station, the medical fluid prepared is uniformly mixed with the rye agar culture medium melted with the volume ratio of 1:9,
Enter in the glass culture dish of 9 cm of preparation, pastille culture medium is made in every 10 mL of ware, is with the sterile water containing 0.1% Tween 80
Control, every concentration set 3 repetitions.For examination phytophthora infestans strain colony edge the bacterium that cut-off meets 5 mm was beaten from growth 10 days
Handle, face down connect on the pastille culture medium plate prepared, are placed under 18 DEG C of dark condition and cultivate about 12 days.When right
When being approximately the 2/3 of culture dish diameter according to colony diameter, colony diameter is measured using crossing method, calculates inhibiting rate.It is united with DPS
Meter analysis software is for statistical analysis, calculates the EC of each medicament50, and according to the co-toxicity coefficient CTC of Sun Yunpei's Method calculating mixture.Examination
Test result as indicated with 1:
As shown in Table 1, dichloro dislikes bacterium azoles and cyazofamid to late blight of potato toxicity test, and cyazofamid virulence is apparently higher than dichloro
The virulence of bacterium azoles is disliked, when the two compound proportion is in the range of 1:30-30:1, co-toxicity coefficient is above 120, shows as cooperateing with
Synergistic effect, when the two compound proportion is 1:10-10:1, for co-toxicity coefficient 170 or more, synergistic function is relatively brighter
It is aobvious.
Two, example of formulations
1: embodiment 1:33% dichloro dislikes bacterium azoles cyazofamid wettable powder (1:1)
Dichloro dislikes bacterium azoles 16.5%
Cyazofamid 16.5%
Neopelex 2%
Sodium lignin sulfonate 6%
White carbon black 15%
Kaolin surplus
The wettable powder sufficiently mixes pesticide original medicine, dispersing agent, wetting agent and filler the preparation method comprises the following steps: pressing above-mentioned formula
It closes uniformly, after ultra-fine pulverizer disintegrating, can be prepared by wettable powder of the present invention.
2, embodiment 2:40% dichloro dislikes bacterium azoles cyazofamid suspending agent (7:3)
Dichloro dislikes bacterium azoles 28%
Cyazofamid 12%
Naphthalenesulfonate formaldehyde condensation compound 4%
Fatty alcohol polyoxyethylene ether 3%
Bentonite 1%
Silicone 0.3%
Urea 3%
Xanthan gum 0.2%
Deionized water surplus
The suspending agent the preparation method comprises the following steps: by above-mentioned formula by water and wetting agent, dispersing agent, thickener, antifreeze and
Defoaming agent mixing, is uniformly mixed through high speed shear, and active constituent is added, and continuation shear-mixed is uniform, and horizontal sand milling is then added
It is ground in machine, so that preparation partial size is at 5 microns hereinafter, can be prepared by suspending agent of the present invention.
3, embodiment 3:39.6% dichloro dislikes bacterium azoles cyazofamid water dispersible granules (1:10)
Dichloro dislikes bacterium azoles 3.6%
Cyazofamid 36%
Methanonaphthalene sodium sulfonate 4%
Alkyl sulfo succinate 5%
Sodium sulphate 3%
Carboxymethyl cellulose 2%
Kaolin surplus
The water dispersible granules the preparation method comprises the following steps: by above-mentioned formula by active constituent and dispersing agent, wetting agent, disintegrating agent, viscous
It ties agent and filler is uniformly mixed, crushed with micro jet, through mediating, is granulated subsequently into Squeezinggranulator, boiling is dry
It is dry in dry machine, through sampling analysis after screening, water dispersible granules of the present invention are made.
4, embodiment 4:18% dichloro dislikes bacterium azoles cyazofamid microemulsion (1:5)
Dichloro dislikes bacterium azoles 3%
Cyazofamid 15%
Calcium dodecyl benzene sulfonate 6%
Cyclohexanone 10%
Dimethylbenzene 15%
Glycerine 3%
Deionized water surplus
The microemulsion the preparation method comprises the following steps: pesticide activity component, solvent, emulsifier and assistant for emulsifying agent are added together, make molten
Solution is in homogeneous oil phase, and antifreeze, deionized water etc. are mixed into uniform water phase, under high velocity agitation, water phase is added to oily phase,
The microemulsion for forming good dispersion property, can be prepared by microemulsion of the present invention.
Three, field control effectiveness test
In order to preferably verify the field practical application effect of bactericidal composition of the invention, using the combination of the embodiment of the present invention
Object carries out prevention and treatment late blight of potato field control effectiveness test, dislikes bacterium azole suspending agent with 20% dichloro and 50% cyazofamid suspending agent is pair
According to medicament, the late blight of potato state of an illness is investigated before application, is administered for the first time in state of an illness initial stage, 7 days after medicine, 14 days difference
Investigation disease index simultaneously calculates preventive effect, and test result is as shown in table 2:
As shown in Table 2, dichloro shows preferable lasting effect to the prevention and treatment of the late blight of potato after disliking bacterium azoles and cyazofamid compounding
And quick-acting, the two are significantly better than control single dose, especially 2 pesticide system of embodiment to the prevention and treatment of the late blight of potato after compounding
Agent, 14 days control efficiency to the late blight of potato are considerably better than other each processing 85% or more after medicine.In addition, in medication
It does not find that composition pesticide of the invention has phytotoxicity generation to crop in range, shows that composition pesticide of the invention pacifies crop
Entirely, it is worthy of popularization.
Claims (9)
1. a kind of Synergistic bactericidal composition, which is characterized in that active constituent, which contains dichloro, dislikes bacterium azoles and cyazofamid.
2. Synergistic bactericidal composition according to claim 1, feature is in the dichloro dislikes the weight of bacterium azoles and cyazofamid
Than for 1:30-30:1.
3. Synergistic bactericidal composition according to claim 2, which is characterized in that the dichloro dislikes the weight of bacterium azoles and cyazofamid
Amount is than being 1:10-10:1.
4. Synergistic bactericidal composition described in any one of -3 claims according to claim 1, which is characterized in that the dichloro
The weight percentage for disliking composition shared by bacterium azoles and cyazofamid is 1-80%.
5. Synergistic bactericidal composition according to claim 4, which is characterized in that the dichloro is disliked shared by bacterium azoles and cyazofamid
The weight percentage of composition is preferably 20-50%.
6. Synergistic bactericidal composition described in any one of -3 claims according to claim 1, which is characterized in that the collaboration
Bactericidal composition can be prepared into any dosage form used in suitable agricultural production.
7. Synergistic bactericidal composition according to claim 6, which is characterized in that the dosage form is selected from missible oil, aqueous emulsion, water
Dispersible granule, wettable powder, microemulsion, suspending agent, seed treatment.
8. Synergistic bactericidal composition described in any one of -7 claims is for preventing and treating corps diseases according to claim 1
Purposes.
9. purposes according to claim 8, which is characterized in that the corps diseases are preferably oomycetes diseases.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710838577.3A CN109511664A (en) | 2017-09-18 | 2017-09-18 | A kind of bactericidal composition for disliking bacterium azoles and cyazofamid containing dichloro |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710838577.3A CN109511664A (en) | 2017-09-18 | 2017-09-18 | A kind of bactericidal composition for disliking bacterium azoles and cyazofamid containing dichloro |
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| CN109511664A true CN109511664A (en) | 2019-03-26 |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101812034A (en) * | 2010-05-11 | 2010-08-25 | 贵州大学 | 2-substituent-5-(2,4-dichlorophenyl)-1,3,4-oxadiazole derivative, synthetic method and application thereof |
| CN102499247A (en) * | 2011-10-17 | 2012-06-20 | 贵州大学 | Oxadiazole sulfone compound for controlling bacterial crop diseases |
| CN104522030A (en) * | 2014-12-18 | 2015-04-22 | 广西田园生化股份有限公司 | Compound composition containing 2-(p-fluorophenyl)-5-methanesulfonyl-1,3,4-oxadiazole and imidazole bactericides and preparation |
-
2017
- 2017-09-18 CN CN201710838577.3A patent/CN109511664A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101812034A (en) * | 2010-05-11 | 2010-08-25 | 贵州大学 | 2-substituent-5-(2,4-dichlorophenyl)-1,3,4-oxadiazole derivative, synthetic method and application thereof |
| CN102499247A (en) * | 2011-10-17 | 2012-06-20 | 贵州大学 | Oxadiazole sulfone compound for controlling bacterial crop diseases |
| CN104522030A (en) * | 2014-12-18 | 2015-04-22 | 广西田园生化股份有限公司 | Compound composition containing 2-(p-fluorophenyl)-5-methanesulfonyl-1,3,4-oxadiazole and imidazole bactericides and preparation |
Non-Patent Citations (1)
| Title |
|---|
| WEIMING XU 等: "Synthesis and bioactivity of novel sulfone derivatives containing 2,4-dichlorophenyl substituted 1,3,4-oxadiazole/thiadiazole moiety as chitinase inhibitors", 《PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY》 * |
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