CN109498074A - Method Wholly-degradable plugging device dedicated driving means and its connect with plugging device - Google Patents
Method Wholly-degradable plugging device dedicated driving means and its connect with plugging device Download PDFInfo
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- CN109498074A CN109498074A CN201910006276.3A CN201910006276A CN109498074A CN 109498074 A CN109498074 A CN 109498074A CN 201910006276 A CN201910006276 A CN 201910006276A CN 109498074 A CN109498074 A CN 109498074A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
- A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
- A61B17/12122—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder within the heart
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
- A61B2017/00575—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
- A61B2017/00575—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
- A61B2017/00623—Introducing or retrieving devices therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00831—Material properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B2017/1205—Introduction devices
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- Heart & Thoracic Surgery (AREA)
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- Surgical Instruments (AREA)
Abstract
The invention discloses a kind of dedicated driving means of Wholly-degradable plugging device, it is characterized in that, including spring steel cable, being equipped in spring steel cable can be fixedly connected with the interior core filaments of fore-aft travel, the front end of spring steel cable with the middle position of binding clip, and the rear end of binding clip is connect with the front end of interior core filaments, the rear end of interior core filaments is connect with sliding block, slide block set pushes on push ring and is also cased with deadlocking member on ring, and spring steel cable is set in push ring；The position that the centre of binding clip is connect with plugging device is equipped with through-hole or binding clip is the double-deck noose or binding clip is mouse tooth-shape structure.Dedicated driving means of the invention matches connection with plugging device, cooperate the use of plugging device, from the angle of engineering science solve completely can will solution plugging device sheath, push, release are pulled in intervention operation the problems such as, be used in its safe and effective through in chest, percutaneous intervention operation.
Description
Technical field
The present invention relates to a kind of minimally invasive intervention surgical medical instrument of surgery more particularly to a kind of Wholly-degradable plugging device are special
With driving means, belongs to Medical treatment device and guard against technical field.
Background technique
The current essential therapeutic arsenals of patients with congenital heart are surgery open chest surgery and percutaneous intervention operation, and surgery is opened
Chest is repaired using sticking patch or simple suture repair heart defect, and percutaneous intervention operation is that implantation NiTi is closed under X-ray development
Golden plugging device blocks defect.With the development of science and technology, the minimally invasive Focal cleaning of surgery becomes the outer chest of set surgery and percutaneous intervention two
The new hybridization modus operandi of one kind of person's advantage.The relatively major trauma that surgery opens chest is avoided, the radiation of X-ray is also avoided,
The implantation of NiTi plugging device and the closure of defect can be completed in operation through ultrasonic guidance merely.
NiTi plugging device some problems as existing for its metal material, such as: metal protection, nickel ion be precipitated,
Small number of patients influences other interventional cardiac procedures operation in patient's later period, metal on nickel ion allergy, block, metal residual
Influence etc. of the implantation material to patient's nuclear magnetic resonance check, in addition, the clinical implantation of the first of NiTi alloys occluder more than 20 years away from the present,
Query is still deposited in long-term safety.
Therefore, there are biggish duration potentiality for the exploitation of degradable plugging device.Currently, having there is a few money parts can in the world
Degradation plugging device has carried out clinical test, only the Carag Bioresorbable Septal Occluder of Carag AG company
(CBSO) CE registration certificate is obtained, the skeleton of the plugging device product is degradable PLA material, and choked flow film is still nondegradable
PET material.The BioSTAR ASD and BioTREK developed by such as NMT company.The choked flow film of this two plugging device is by completely may be used
The collagen of degradation is made, but the skeleton that BioSTAR ASD plugging device plays a supportive role is still nondegradable metal
Material, therefore the plugging device of Wholly-degradable cannot be can be regarded as.Although BioTREK plugging device is Wholly-degradable, but be implanted into
Several hours materials start to degrade afterwards, and degradation rate is too fast, mismatch with endothelialization rate.
2 months 2018, Shanghai Form Memory Alloy Materials Co., Ltd has carried out in Fuwai Hospital, Yunnan Province can drop completely
Solve the first clinical implantation in the whole world of plugging device.The plugging device of current clinical implantation is prepared by biological absorbable material completely, and nothing is appointed
What metal material, skeleton are polydioxanone (PDO) material, as shown in Figure 1a.
Although being manufactured that the plugging device of Wholly-degradable using Biodegradable material from material,
It is how the plugging device to be implanted to defect location by intervention means from modus operandi and safe release is from engineering angle
Problem to be solved on degree.
The framework material polydioxanone (PDO) of Wholly-degradable plugging device is due to lower glass transition temperature
(Tg) just very soft at room temperature, it is conducive to braiding and customization, but the material is unfavorable for high-precision in size since fusing point is relatively low
Degree processing, therefore, traditional NiTi plugging device is commonly threadedly coupled that can not be applied on Wholly-degradable plugging device (can not be complete
Screw thread is processed based on PDO material on complete degradable plugging device).
To solve the above problems, the solution provided first is the annulus for being woven into a snare shape using PDO material
It is added in the right disk bottom of plugging device, then designs the driving means of a Tourniquet clamping head (or binding clip), which is woven into marmon clamp
Firmly post-tensioning or plugging device is pushed away, it is made to push and discharge or is recycled.
In fact, the design comparison it is easy to accomplish be the operation for pulling in sheath to Wholly-degradable plugging device, push
Different effects is presented with the variation of occluder size in effect, and specifically, i.e., the plugging device of small size is easy to push, and size
The more difficult push of slightly larger plugging device.It is indirect force that this, which is primarily due to the annular connection between snare ring and plugging device main body rack,
Effect, rather than direct force acts on.
Therefore, the connecting portion for how designing plugging device and driving means makes it effectively realize that Wholly-degradable blocks
Device pulls in the operation such as sheath, push, release, is suitble to the operation of intervention operation.
Summary of the invention
Wholly-degradable plugging device how is made to be suitble to intervention operation behaviour the technical problem to be solved by the present invention is solving
The problem of making.
In order to solve the above-mentioned technical problem, the technical solution of the present invention is to provide a kind of Wholly-degradable plugging device is dedicated
Driving means, which is characterized in that including spring steel cable, being equipped in spring steel cable can be with the interior core filaments of fore-aft travel, spring steel cable
Front end be fixedly connected with the middle position of binding clip, the rear end of binding clip is connect with the front end of interior core filaments, the rear end of interior core filaments and cunning
Block connection, slide block set push on push ring and are also cased with deadlocking member on ring, and spring steel cable is set in push ring；The centre of binding clip
The position connecting with plugging device is equipped with through-hole or binding clip is the double-deck noose or binding clip is mouse tooth-shape structure.
Preferably, the binding clip is the double-deck noose, and the both ends of the double-deck noose are fixed on the front end of spring steel cable, interior core filaments
The hole surrounded among the double-deck noose.
Preferably, the binding clip is mouse tooth-shape structure, and binding clip includes 2 intermediate plates mutually staggered, and every intermediate plate is " L "
Shape structure, the upper end of L shape structure intermediate plate and the front end of spring steel cable connect, lower end and the interior core filaments of L shape structure intermediate plate
Front end connection.
Preferably, the binding clip includes the intermediate plate of 2 encircling types, and 2 intermediate plates form an arc-shaped top after merging,
There is a circular through-hole at the top center of dome.
Preferably, the diameter of the through-hole is (0.8 ± 0.1) mm.
A kind of method that the dedicated driving means of Wholly-degradable plugging device is connect with plugging device, which is characterized in that including with
Lower step: by the PDO silk of the right disk bottom end of Wholly-degradable plugging device bracket by way of hot melt clinkering at a cylinder
Shape structure, so that the non-clinkering PDO silk material of Wholly-degradable plugging device passes through out of binding clip through-hole, 2 intermediate plates are just clamped
The cylindrical-shaped structure of right disk bottom end.
Preferably, the surface of the cylindrical-shaped structure is rough surface；Clinkering position can also be spherical or inverted triangle
Shape.
Preferably, PDO silk hot melt processing when heating be originally air-heater or hot-air welding machine or alcolhol burner or
Alcohol blast burner.
Preferably, PDO silk hot melt is 350 DEG C~550 DEG C at temperature required for cylindrical-shaped structure.
Preferably, PDO silk hot melt is 400 DEG C~500 DEG C at temperature required for cylindrical-shaped structure.
Dedicated driving means of the invention matches connection with plugging device, cooperates the use of plugging device, from the angle of engineering science
It solves the problems such as solution plugging device can be pulled in sheath, push, release in intervention operation completely, makes its safe and effective quilt
It is used in through in chest, percutaneous intervention operation.
Detailed description of the invention
Fig. 1 a is Wholly-degradable plugging device schematic diagram (skeleton is PDO material)；
Fig. 1 b is Wholly-degradable plugging device schematic diagram (the PDO silk clinkering of right disk bottom end is cylindric)；
Fig. 1 c is Wholly-degradable plugging device schematic diagram (the PDO silk clinkering of right disk bottom end is spherical)；
Fig. 1 d is Wholly-degradable plugging device schematic diagram (the PDO silk clinkering inverted triangle shape of right disk bottom end)；
Fig. 1 e is Wholly-degradable plugging device schematic diagram (double end is without riveting)；
Fig. 1 f is the top view of Fig. 1 e；
Fig. 1 g is the bottom view of Fig. 1 e；
Fig. 1 h is Wholly-degradable plugging device schematic diagram (right disk bottom end is equipped with annulus)；
Fig. 1 i is Wholly-degradable plugging device schematic diagram (double end has riveting)；
Fig. 2 a is a kind of schematic diagram of dedicated driving means of Wholly-degradable plugging device；
Fig. 2 b is the main view of binding clip；
Fig. 2 c is the top view of Fig. 2 b；
Fig. 3 is that Wholly-degradable plugging device and dedicated driving means cooperate schematic diagram；
Fig. 4 a is the schematic diagram of mouse tooth form binding clip；
Fig. 4 b is the left view of Fig. 4 a；
Fig. 4 c is the schematic diagram of the mouse tooth form binding clip open configuration in Fig. 4 a；
Fig. 5 a is the schematic diagram that Wholly-degradable plugging device and dedicated driving means cooperate otherwise；
Fig. 5 b is the partial enlarged view of Wholly-degradable plugging device and dedicated driving means junction.
Specific embodiment
In order to make the present invention more obvious and understandable, hereby with preferred embodiment, and attached drawing is cooperated to be described in detail below.
Embodiment 1
A kind of dedicated driving means of Wholly-degradable plugging device, as shown in Figure 2 a comprising push wirerope 2 and handle push away
Sending wirerope 2 includes binding clip 1, spring steel cable 7 and interior core filaments 6；Handle includes push ring 5, sliding block 4 and deadlocking member 3.
Being equipped in spring steel cable 7 can be with the interior core filaments 6 of fore-aft travel, the front end of spring steel cable 7 and the middle position of binding clip 1
It is fixedly connected, the rear end of binding clip 1 is connect with the front end of interior core filaments 6, and the rear end of interior core filaments 6 is connect with sliding block 4, and 4 sets of sliding block are pushing away
It send on ring 5, pushes and be also cased with deadlocking member 3 on ring 5, spring steel cable 7 is set in push ring 5.
Binding clip is designed as the intermediate plate of 2 encircling types, as shown in Figure 2 b, an arc-shaped top is formed after merging, in circular arc
There is a circular through-hole at the position that the top center on top is connect with plugging device, the diameter of the through-hole is (0.8 ± 0.1)
mm.When conveying, the clinkering cylinder of the right disk bottom end of plugging device is placed between two intermediate plates of the binding clip 1, after intermediate plate merges, completely may be used
The non-clinkering PDO silk material of degradation plugging device passes through out of binding clip 1 through-hole, makes have firm connection between plugging device and binding clip 1.
On binding clip 1 aperture design mainly solve the problems, such as the non-clinkering silk of plugging device by, if be not open herein, binding clip
1 can not just be closed completely, and the protuberance of a larger size is formed after causing binding clip 1 and plugging device tail end junction to clamp, this
Protuberance can seriously affect the size that plugging device crosses sheath, and making can only with the Wholly-degradable plugging device of size with tradition NiTi plugging device
The sheath of excessive several specification.After the design very good solution of 1 aperture of binding clip clamping plugging device tail end closure binding clip 1, pincers
First 1 dimensional problem makes it the sheath by smaller size, increases operability clinically, blocks with traditional NiTi
The sheath ability excessively of device is equally matched.
What the chucking power of binding clip 1 was enough to ensure that plugging device pulls in sheath and the push in sheath.The intermediate plate of binding clip 1 separates
Afterwards, plugging device, that is, releasable.
Before the binding clip of such design is connect with Wholly-degradable plugging device, need to change Wholly-degradable plugging device
Processing is made, specific as follows:
By the PDO silk of the right disk bottom end of Wholly-degradable plugging device bracket by way of hot melt clinkering at a cylinder
Shape structure, and the surface of cylindrical-shaped structure facilitates the folder of dedicated driving means binding clip for coarse surface to increase frictional force
It holds；The schematic diagram of clinkering cylinder, as shown in Figure 1 b；The schematic diagram of driving means binding clip, as shown in Figure 2 a；Clinkering position can also be with
It is other shapes, such as spherical (Fig. 1 c), inverted triangle shape (Fig. 1 d)；
PDO hot melt processing methods need the stable heating for being capable of providing high temperature former, which can be
Air-heater, hot-air welding machine, alcolhol burner, alcohol blast burner etc.；
By PDO hot melt at cylindric required temperature be 350 DEG C~550 DEG C, specific hot melting temperature be 400 DEG C~
500℃。
Handle includes push ring 5, sliding block 4 and deadlocking member 3, and as shown in Figure 2 a, push handle primarily serves open or close
Binding clip 1, lock or the effect of unlock binding clip 1, specific operation are as follows: sliding block 4 forward, binding clip 1 are opened；Sliding block 4 backward,
Binding clip 1 is closed；Deadlocking member 3 is rotated clockwise to maximum limit, sliding block 4 is immovable, and binding clip 1 is closed and locks, and revolves counterclockwise
Turn deadlocking member 3 and exit limit, sliding block 4 can move, and binding clip 1 can be opened.
As shown in figure 3, the method that is used cooperatively of Wholly-degradable plugging device and dedicated driving means of the invention describes such as
Under:
1, sheath is pulled in:
The loader to match is mounted in advance on push wirerope 2；Confirm that the deadlocking member 3 of driving means is in maximum unlock shape
State pushes sliding block 4, opens binding clip 1, the clinkering column of the right disk bottom end of Wholly-degradable plugging device is put into the pincers of driving means
In first 1, sliding backward sliding block 4 is closed binding clip 1, and confirms that the tail end of Wholly-degradable plugging device is clipped completely, non-clinkering
PDO silk all pass through the circular hole of binding clip 1；Deadlocking member 3 to maximum is rotated clockwise to limit；Pull driving means handle or push
Wirerope 2 is incorporated into Wholly-degradable plugging device in loader.
2, it pushes:
Confirm that the deadlocking member 3 of driving means is in maximum spacing place, pushes driving means handle or push wirerope 2, made
Complete degradable plugging device is pushed into outer tube, until heart defect position, and smoothly discharge disk up and down；
3, plugging device (separation) is discharged:
Rotation deadlocking member 3 counterclockwise, is at maximum unlocked state, then pushes sliding block 4 forward, and binding clip 1 is opened, pincers
First 1 separates with plugging device；It pushes sliding block 4 backward again, is closed binding clip 1, take in sheath, and withdrawn from vitro with sheath.
Embodiment 2
In the present embodiment, binding clip 1 be mouse tooth form (two tooth forms) structure, binding clip 1 include 2 intermediate plates mutually staggered, every
Intermediate plate is mouse tooth form (L shape) structure, as shown in Fig. 4 a- Fig. 4 c, upper end and the spring steel cable 7 of L shape structure intermediate plate
Front end connection, the lower end of L shape structure intermediate plate is connect with the front end of interior core filaments 6.Clinkering portion of the binding clip of the design to plugging device
Bit architecture has no special requirements, such as rough surface (function of not influencing binding clip whether not needing be coarse or coarse), or even envelope
Stifled device can be without tail end.2 mouse teeth catch the right disk bottom of plugging device that can pull in plugging device in sheath.
Other are same as Example 1.
Embodiment 3
As shown in Fig. 5 a, Fig. 5 b, binding clip 1 is the double-deck noose 8, before the both ends of the double-deck noose 8 are fixed on spring steel cable 7
End, interior core filaments 6 pass through the hole surrounded among the double-deck noose 8.It is the interior core filaments 6 that can be slided, handle among spring steel cable 7
On the adjustable interior core filaments 6 of sliding block it is flexible.Sliding block is specially pushed forward, and interior core filaments 6 forward extend out, and slide backward cunning
Block, interior core filaments 6 retract backward.The both ends of the double-deck noose 8 are all fixed on same position (the i.e. groove 9 of the head end of spring steel cable 7
It is interior).When in use, from double end without riveting, or the single degradable plugging device of riveting passes through the double-deck noose 8 without riveting end, and interior core filaments 6
It to be passed through from the centre of the double-deck noose 8, all the way through plugging device, as shown in Figure 5 a.Degradable plugging device and driving means are secured
After connection, plugging device is taken in into loader.
It is defeated without the degradable plugging device of riveting without riveting, single head that the driving means as shown in Fig. 5 a, Fig. 5 b cannot be only used for double end
It send, it may also be used for conveying of the double end without riveting or single head without the non-degradable plugging device of riveting, such as the plugging device of NiTi alloy braiding.
Other are same as Example 1.
Claims (10)
1. a kind of dedicated driving means of Wholly-degradable plugging device, which is characterized in that including spring steel cable (7), spring steel cable (7)
Interior be equipped with can be fixedly connected with the interior core filaments (6) of fore-aft travel, the front end of spring steel cable (7) with the middle position of binding clip (1), be clamped
The rear end of head (1) is connect with the front end of interior core filaments (6), and the rear end of interior core filaments (6) is connect with sliding block (4), and sliding block (4), which covers, to be pushed
It on ring (5), is also cased with deadlocking member (3) in push ring (5), spring steel cable (7) is set in push ring (5)；The centre of binding clip (1) with
The position of plugging device connection is equipped with through-hole or binding clip (1) is the double-deck noose (8) or binding clip (1) is mouse tooth-shape structure.
2. a kind of dedicated driving means of Wholly-degradable plugging device as described in claim 1, which is characterized in that the bilayer
The both ends of noose (8) are fixed on the front end of spring steel cable (7), and interior core filaments (6) pass through the hole surrounded among the double-deck noose (8).
3. a kind of dedicated driving means of Wholly-degradable plugging device as described in claim 1, which is characterized in that the binding clip
It (1) include 2 intermediate plates mutually staggered, every intermediate plate is L shape structure, the upper end and spring steel cable (7) of L shape structure intermediate plate
Front end connection, the lower end of L shape structure intermediate plate is connect with the front end of interior core filaments (6).
4. a kind of dedicated driving means of Wholly-degradable plugging device as described in claim 1, which is characterized in that the binding clip
(1) include 2 encircling types intermediate plate, 2 intermediate plates form an arc-shaped top, have at the top center of dome after merging
One circular through-hole.
5. a kind of dedicated driving means of Wholly-degradable plugging device as claimed in claim 4, which is characterized in that the through-hole
Diameter be (0.8 ± 0.1) mm.
6. a kind of method that the dedicated driving means of Wholly-degradable plugging device as claimed in claim 4 is connect with plugging device,
It is characterized in that, comprising the following steps: by the PDO silk of the right disk bottom end of Wholly-degradable plugging device bracket by way of hot melt
Clinkering is at a cylindrical-shaped structure, so that the non-clinkering PDO silk material of Wholly-degradable plugging device is led to out of binding clip (1) through-hole
It crosses, 2 intermediate plates just clamp the cylindrical-shaped structure of right disk bottom end.
7. a kind of method that the dedicated driving means of Wholly-degradable plugging device is connect with plugging device as claimed in claim 6,
It is characterized in that, the surface of the cylindrical-shaped structure is rough surface；Clinkering position can also be spherical or inverted triangle shape.
8. a kind of method that the dedicated driving means of Wholly-degradable plugging device is connect with plugging device as claimed in claim 6,
It is characterized in that, the heating when hot melt of the PDO silk is processed was air-heater or hot-air welding machine or alcolhol burner or alcohol spray originally
Lamp.
9. a kind of method that the dedicated driving means of Wholly-degradable plugging device is connect with plugging device as claimed in claim 6,
It is characterized in that, the PDO silk hot melt is 350 DEG C~550 DEG C at temperature required for cylindrical-shaped structure.
10. a kind of method that the dedicated driving means of Wholly-degradable plugging device is connect with plugging device as claimed in claim 9,
It is characterized in that, the PDO silk hot melt is 400 DEG C~500 DEG C at temperature required for cylindrical-shaped structure.
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| CN201910006276.3A CN109498074A (en) | 2019-01-04 | 2019-01-04 | Method Wholly-degradable plugging device dedicated driving means and its connect with plugging device |
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| CN201910006276.3A CN109498074A (en) | 2019-01-04 | 2019-01-04 | Method Wholly-degradable plugging device dedicated driving means and its connect with plugging device |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110477969A (en) * | 2019-07-08 | 2019-11-22 | 江苏省肿瘤医院 | A kind of fistula hole plugging system |
| CN110876633A (en) * | 2019-12-03 | 2020-03-13 | 江苏博朗森思医疗器械有限公司 | Special conveyor for degradable plugging device |
| WO2021253980A1 (en) * | 2020-06-16 | 2021-12-23 | 上海形状记忆合金材料有限公司 | Head end enveloping-type clamping and conveying system |
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