CN109432481A - A kind of polyurethane dressing of hemostatic and antibacterial and preparation method thereof - Google Patents
A kind of polyurethane dressing of hemostatic and antibacterial and preparation method thereof Download PDFInfo
- Publication number
- CN109432481A CN109432481A CN201811489303.9A CN201811489303A CN109432481A CN 109432481 A CN109432481 A CN 109432481A CN 201811489303 A CN201811489303 A CN 201811489303A CN 109432481 A CN109432481 A CN 109432481A
- Authority
- CN
- China
- Prior art keywords
- parts
- polyurethane
- dressing
- chitosan
- hemostatic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials For Medical Uses (AREA)
Abstract
The present invention relates to polyurethane dressing of a kind of hemostatic and antibacterial and preparation method thereof.The polyurethane dressing includes the ingredient of following parts by weight: dehydration 30~50 parts of polyethylene glycol, 1~10 part of chitosan, usnic acid 1~10,5~10 parts of 1% acetum, 1~5 part of glycerol, 20~40 parts of toluene di-isocyanate(TDI), 0.5~2 part of nano-titanium dioxide, 1~20 part of polyether polyol, 0.5~1.5 part of stannous octoate, 0.5~1.5 part of dimethylethanolamine, 0.5~5.0 part of silicon surface active agent.Polyurethane dressing of the invention the preparation method is as follows: A, weighing chitosan, usnic acid in 1% acetum solution, stirring and dissolving is stood until completely dissolved, filters out insoluble matter, obtains solution A；B, the preparation of performed polymer: by solution A, dehydration polyethylene glycol, glycerol, toluene di-isocyanate(TDI) mixing, stirring, insulation reaction obtains performed polymer；C, foam: polyether polyol, stannous octoate, dimethylethanolamine, silicon surface active agent are uniformly mixed, be added nano-titanium dioxide, stirring, be added performed polymer, foam after mixing, curing to get.Polyurethane foam dressing provided by the invention not only has hemostatic function, and has broad-spectrum sterilization performance.
Description
Technical field
The invention belongs to medical instruments fields, and in particular to a kind of polyurethane dressing of hemostatic and antibacterial and preparation method thereof.
Background technique
In various surgical operations, bleeding is reduced, shortens operating time, there is important influence to patient's prognosis.Properly
Hemostatic material can be obviously shortened operating time, it is most important to wound or post-operative recovery.
The dressing type clinically used has very much, wherein foam type polyurethane medical dressing is suitable for wound granulation shape
Cheng Qi, foam type dressing can absorb extra wound fluid, while can obstruct external foreign matter and part bacterium, protection exposure
Nerve endings, mitigate pain.Meanwhile foam dressing is moistened due to keeping, so as to avoid the excessive evaporation of surface of a wound exudate
And dry scab is formed, therefore property mechanical injuries again will not be generated in more change dressings, be conducive to the healing of the surface of a wound.
The bacterial species of wound are relatively more, and common pathogen has staphylococcus, streptococcus, Escherichia coli etc..Its main feature is that:
Same pathogenic bacteria can cause several different pyogenic infections, as staphylococcus aureus can cause furuncle, carbuncle, abscess, wound
Mouthfeel dye etc.；And different pathogenic bacteria can cause same disease, all such as staphylococcus aureus, streptococcus and Escherichia coli
It can cause acute cellulitis, Soft Tissue Abscess: An Experimental, wound infection etc..There is a common domestic animal feature of purulent inflammation, i.e., red, swollen, hot,
Pain and dysfunction.Also there is common point in prevention and treatment.Although existing antiseptic dressing has the effect of antibacterial, major part can not
Realize long-acting bacteriostatic, and the narrow range of antibacterial, effect are poor.
Chinese patent CN105497963A discloses a kind of trauma hemostasis polyurethane dressing, is mainly prepared by following raw materials according
It forms: polyethylene glycol, glycerol, methyl diphenylene diisocyanate, polyethers, chloroform, catalyst, radix scutellariae, Rhizoma Et Radix Notopterygii, setose thistle,
Japanses beauty-berry grass, catechu, fresh rehmannia root, alum fall certain herbaceous plants with big flowers, radish, great burdock achene.The present invention has preferable hydrophily, can absorb wound and seeps
Blood and sepage, haemostatic effect is good, and the present invention effectively extracts the effective component in chinese medicine material, can promote wound healing, prevention sense
Dye, the present invention and surface of a wound adhesion, Yi Genghuan prevent secondary insult.
Chinese patent CN107335089A discloses a kind of modified hydrophilic polyurethane dressing and preparation method thereof, the dressing
Including following component: polyurethane, collagen, hyaluronic acid, chitosan, egg white, sodium alginate, Cordyceps, silver nanoparticle
Solution, carboxymethyl cellulose, bamboo fibre, acetylcellulose sodium.Preparation method: each component is weighed by weight；By polyurethane,
Collagen, hyaluronic acid, chitosan, egg white and sodium alginate melt in a kettle, and after being down to 50~60 DEG C, remaining is added
Raw material, it is spare that cooling deaeration obtains the first mixture；First mixture is coated on colloid layer, spontaneously drying post package must be modified
Hydrophilic polyurethane dressing.Compared with prior art, there is preferable performance of keeping humidity, good antimicrobial effect non-stimulated to skin is fitted
Conjunction is widely applied and applies.
Currently, clinically common polyurethane medical dressing only has simple moisture retention, the surface of a wound has various bacteria
Infection, therefore, for the performance for improving dressing, urgent need researches and develops a kind of polyurethane dressing with hemostatic and antibacterial, wound can be helped to stop
Blood kills bacterium and inhibits the bacterial growth of wound, to accelerate wound healing.
Summary of the invention
The present invention provides composition and polyurethane dressing of a kind of hemostatic and antibacterial and preparation method thereof, not only has hemostasis
Function, and there is broad-spectrum sterilization performance, thallus remains can be handled, keep bactericidal property more thorough.The technical side that the present invention takes
Case is as follows:
A kind of composition of hemostatic and antibacterial, including following components and parts by weight: 1~10 part of chitosan, usnic acid 1~10,
1% 5~10 parts of acetum.
Preferably, a kind of composition of hemostatic and antibacterial, including following components and parts by weight: 5 parts of chitosan, 6 parts of usnic acid,
1% 10 parts of acetum.
A kind of polyurethane dressing of hemostatic and antibacterial, the ingredient comprising following parts by weight: dehydration 30~50 parts of polyethylene glycol, shell
1~10 part of glycan, usnic acid 1~10,5~10 parts of 1% acetum, 1~5 part of glycerol, 20~40 parts of toluene di-isocyanate(TDI),
0.5~2 part of nano-titanium dioxide, 1~20 part of polyether polyol, 0.5~1.5 part of stannous octoate, dimethylethanolamine 0.5~
1.5 parts, 0.5~5.0 part of silicon surface active agent.
Preferably, the polyurethane dressing of a kind of hemostatic and antibacterial, the ingredient comprising following parts by weight: dehydration polyethylene glycol 45
Part, 5 parts of chitosan, 6 parts of usnic acid, 10 parts of 1% acetum, 3 parts of glycerol, 30 parts of toluene di-isocyanate(TDI), nanometer titanium dioxide
1.5 parts of titanium, 15 parts of polyether polyol, 1.0 parts of stannous octoate, 1.0 parts of dimethylethanolamine, 3.0 parts of silicon surface active agent.
Further, the molecular weight of chitosan is 10000~100000.
Further, nano-titanium dioxide is Detitanium-ore-type, and partial size is 1~100nm.
Further, polyether polyol is end ring oxygen polyether polyol or amine terminated polyether polyalcohol.
Further, the silicon surface active agent is silicone surfactant.
The present invention also provides a kind of preparation methods of the polyurethane dressing of hemostatic and antibacterial, include the following steps:
A, chitosan, usnic acid are weighed in 1% acetum, stirring and dissolving is stood until completely dissolved, is filtered out not
Molten object, obtains solution A；
B, the preparation of performed polymer: by step A acquired solution, dehydration polyethylene glycol, glycerol, toluene di-isocyanate(TDI) is mixed,
Stirring, 80~85 DEG C insulation reaction 1~2 hour, obtain thick performed polymer；
C, it foams: weighing polyether polyol, stannous octoate, dimethylethanolamine, silicon surface active agent, be uniformly mixed, connect
Addition nano-titanium dioxide, quickly stir evenly, performed polymer obtained by step B, immediately high-speed stirred 1~2 hour, mixing be added
Foaming mould is poured into rapidly after uniformly to foam, and cures 20~30 hours to get polyurethane dressing.
Further, dressing of the present invention is when in use with semi permeability thermoplastic polyurethane elastomer (TPU) waterproof back
Lining is fixed.
Chitosan of the present invention is a kind of natural biological material quickly grown in biomedicine field nearly ten years
Material.The main performance of chitosan has: 1, bacteria resistance function: chitosan is to many microorganisms, such as bacterium, fungi and saccharomycete, all
There is different degrees of inhibiting effect；2, wound healing function: chitosan energy immune cell activated, inflammatory cell, macrophage are thin
The activity of born of the same parents, fibroblast and vascular endothelial cell, in wound, chitosan can be by influencing dividing for F parts of F
It secretes to stimulate fibroblast generation and collagen synthesis, further connective tissue is promoted to be formed；3, hemostatic function: chitosan
Positive charge on molecule can make erythrocyte aggregation, finally start hemostatic function in conjunction with the negative electrical charge of erythrocyte surface.
The nano-titanium dioxide that the present invention uses has excellent chemical stability, thermal stability and non-for inorganic constituents
Migration and stronger reducing power, covering power, lower corrosivity, good easily disperse, and nontoxic, tasteless and nonirritant
Property, use is safe, also has the effect of deodorization and sterilization concurrently.The antibacterial mechanisms of titanium dioxide are to make organic matter point based on light-catalyzed reaction
It solves and there is antibacterial action.Titanium dioxide has the function of decomposing pathogen and toxin.To Pseudomonas aeruginosa, Escherichia coli, golden yellow
Color staphylococcus, salmonella, bud branch bacterium and aspergillus etc. have very strong sterilizing ability, are a kind of broad spectrum antimicrobial agents.The present invention
The usnic acid of use is a kind of antibiotic of wide spectrum, has powerful inhibiting effect to most gram-positive bacteriums, can also inhibit
The growth of tulase, concentration, which reaches 50ug/ml, can completely inhibit bacterial growth.
Therefore, the addition of chitosan, usnic acid makes sponge have effects that hemostatic and antibacterial, and joined nanometer titanium dioxide
Titanium, antibacterial action further strengthen.
In conclusion the invention has the following advantages:
(1) polyurethane dressing of the invention has hemostatic function, under the premise of keeping performance of keeping humidity, can accelerate wound wound
Face healing；
(2) polyurethane dressing of the invention also has broad-spectrum sterilization performance, can handle thallus remains, makes bactericidal property more
Thoroughly.
Specific embodiment
The following describes the present invention further through the description of specific embodiments, but it is to limit of the invention that this, which is not,
System, those skilled in the art's basic thought according to the present invention can make various modifications or improvements, but without departing from this
The basic thought of invention, is all within the scope of the present invention.
Embodiment 1: a kind of preparation method of the polyurethane dressing of hemostatic and antibacterial includes the following steps:
A, the preparation of chitosan solution: chitosan, usnic acid are added in 1% acetum, stirring, until completely dissolved
It stands, falls insoluble matter with the filter screen filtration of 100 mesh, sodium hydroxide solution is added to pH to 8.0, repeatedly washed with distilled water and be
Gel aqueous dispersion is obtained, vacuum drying obtains microcrystalline powder；It weighs microcrystalline powder to be dissolved in purified water, stirring and dissolving, it is poly- to obtain shell
Sugar juice；
B, the preparation of performed polymer: by chitosan solution obtained by step A, dehydration polyethylene glycol, glycerol, toluene di-isocyanate(TDI)
Mixing, stirring, 83 DEG C insulation reaction 1.5 hours, obtain thick performed polymer；
C, it foams: weighing polyether polyol, stannous octoate, dimethylethanolamine, silicon surface active agent, be uniformly mixed, connect
Addition nano-titanium dioxide, quickly stir evenly, performed polymer obtained by step B, immediately high-speed stirred 1.5 hours, mixing be added
Foaming mould is poured into rapidly after uniformly to foam, and cures 25 hours to get polyurethane dressing.
Test example 1:
Bactericidal property (GB 15979- is carried out respectively to polyurethane sponge dressing prepared by embodiment 1-3, comparative example 1-3
2002 appendix Cs), cytotoxicity (GB/T14233.2-2005 chapter 8), sensitization (GB/T16886.10-2005 chapter 7),
Intradermal reaction (GB/T16886.10-2005), systemic acute toxi-city (GB/T 16886.11-2011 chapter 5), testing result is such as
Shown in the following table 1.The testing result for the polyurethane sponge dressing that 1-3 of the embodiment of the present invention is provided is shown, provided by the present invention to stop
The polyurethane dressing of blood antibacterial has good bactericidal property, while showing no sensitization, no cytotoxicity and whole body
Toxicity etc., provided sponge dressing is harmless, has mainly met the examination criteria of medical and sanitary products.Comparative example 1 is right
Than embodiment 3, chitosan solution is not added, nano-titanium dioxide is not added, both fails to reach for 2 comparative example 4 of comparative example
To bactericidal effect, chitosan solution and usnic acid and nano-titanium dioxide are not added for comparative example 3, entirely without bactericidal properties.
Test example 2:
The related experiment of functions of stanching and promoting healing
Using SD rat as experimental animal, half male and half female is randomly divided into 4 groups, every group 10, tests Wound dressing shield of the present invention
Create effect.By rat anesthesia back part unhairing, disinfection cuts the skin of 1cm × 1cm at back, the root after blood is full of the surface of a wound
Apply pressure haemostatic measures are taken according to grouping, record bleeding stopping period, observation counts wound healing rate after a week, see the table below.
Promoting healing test result
| Experimental project | Bleeding stopping period (s) | Healing rate (%) |
| Embodiment 3 | 10 | 99.8 |
| Comparative example 1 | 35 | 62.1 |
| Comparative example 4 | 32 | 69.8 |
| Comparative example 5 | 52 | 32.8 |
As can be seen from the table, 3 bleeding stopping period of embodiment is fast and promotes the effect of wound healing good, chitosan and usnic acid group
Conjunction can shorten bleeding stopping period, promote wound healing, can accelerate the anthemorrhagic speed of polyurethane sponge dressing, enhance the healing to wound
Rate is indispensable.
Claims (10)
1. a kind of composition of hemostatic and antibacterial, which is characterized in that the composition includes following components and parts by weight: chitosan 1
~10 parts, usnic acid 1~10,5~10 parts of 1% acetum.
2. hemostatic composition as described in claim 1, which is characterized in that the composition includes following components and parts by weight:
5 parts of chitosan, 6 parts of usnic acid, 10 parts of 1% acetum.
3. the application that a kind of hemostatic composition as claimed in claim 1 or 2 prepares dressing.
4. a kind of polyurethane dressing of hemostatic and antibacterial, which is characterized in that the polyurethane dressing includes as claimed in claim 1 or 2
Composition.
5. polyurethane as claimed in claim 4, which is characterized in that the polyurethane dressing further include dehydration polyethylene glycol 30~
50 parts, 1~5 part of glycerol, 20~40 parts of toluene di-isocyanate(TDI), 0.5-2 parts of nano-titanium dioxide, 1~20 part of polyether polyol,
0.5~1.5 part of stannous octoate, 0.5~1.5 part of dimethylethanolamine, 0.5~5.0 part of silicon surface active agent.
6. polyurethane dressing according to claim 4 or 5, which is characterized in that the ingredient comprising following parts by weight: dehydration is poly-
45 parts of ethylene glycol, 6 parts of usnic acid, 10 parts of 1% acetum, 3 parts of glycerol, 30 parts of toluene di-isocyanate(TDI), is received 5 parts of chitosan
Rice 1.5 parts of titanium dioxide, 15 parts of polyether polyol, 1.0 parts of stannous octoate, 1.0 parts of dimethylethanolamine, silicon surface active agent
3.0 part.
7. polyurethane dressing according to claim 4 or 5, which is characterized in that the molecular weight of the chitosan be 10000~
100000。
8. polyurethane dressing according to claim 4 or 5, which is characterized in that the nano-titanium dioxide is Detitanium-ore-type,
Partial size is 1~100nm, and the polyether polyol is end ring oxygen polyether polyol or amine terminated polyether polyalcohol, the silicon face
Activating agent is silicone surfactant.
9. polyurethane dressing according to claim 4 or 5, which is characterized in that the dressing is when in use with semi permeability warm
Plastic polyurethane elastomer (TPU) waterproof backing is fixed.
10. according to the preparation method of any polyurethane dressing of claim 4--9, it is characterised in that include the following steps:
A, chitosan, usnic acid are weighed in 1% acetum, stirring and dissolving is stood until completely dissolved, is filtered out insoluble
Object obtains solution A；
B, the preparation of performed polymer: by step A acquired solution, dehydration polyethylene glycol, glycerol, toluene di-isocyanate(TDI) mixing is stirred,
80~85 DEG C insulation reaction 1~2 hour, obtain thick performed polymer；
C, foam: weigh polyether polyol, stannous octoate, dimethylethanolamine, silicon surface active agent, be uniformly mixed, then plus
Enter nano-titanium dioxide, quickly stir evenly, performed polymer obtained by step B is added, immediately high-speed stirred 1~2 hour, is uniformly mixed
It pours into foaming mould rapidly afterwards to foam, cures 20~30 hours to get polyurethane dressing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811489303.9A CN109432481A (en) | 2018-12-06 | 2018-12-06 | A kind of polyurethane dressing of hemostatic and antibacterial and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811489303.9A CN109432481A (en) | 2018-12-06 | 2018-12-06 | A kind of polyurethane dressing of hemostatic and antibacterial and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109432481A true CN109432481A (en) | 2019-03-08 |
Family
ID=65556808
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811489303.9A Withdrawn CN109432481A (en) | 2018-12-06 | 2018-12-06 | A kind of polyurethane dressing of hemostatic and antibacterial and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109432481A (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109880052A (en) * | 2019-03-20 | 2019-06-14 | 亳州科蔚科技服务有限公司 | A kind of medical bandage coating preparation method of polyurethane resin compound material |
| CN112266455A (en) * | 2020-09-29 | 2021-01-26 | 万华化学集团股份有限公司 | Modified high blood absorption polyurethane sponge, preparation method and application thereof |
| CN113041389A (en) * | 2021-05-06 | 2021-06-29 | 南昌智产科技有限公司 | Medical dressing of antibiotic hydrophilic polyurethane foam |
| TWI733144B (en) * | 2019-07-22 | 2021-07-11 | 中鎮醫療產品科技股份有限公司 | Water glue for scar film and its preparation method |
| CN113713163A (en) * | 2021-09-09 | 2021-11-30 | 武汉理工大学 | Hydrophilic polyurethane dressing and preparation method thereof |
| CN113754853A (en) * | 2021-09-14 | 2021-12-07 | 武汉理工大学 | Antibacterial medical drainage polyurethane foam and preparation method thereof |
| CN114306721A (en) * | 2022-01-12 | 2022-04-12 | 河北卫崭医疗科技有限公司 | Waterproof and breathable foam dressing and preparation method thereof |
| CN114848884A (en) * | 2022-05-17 | 2022-08-05 | 山东万容生物科技有限公司 | Polyurethane foam dressing and preparation method thereof |
| CN116672488A (en) * | 2023-07-17 | 2023-09-01 | 泰州市榕兴医疗用品股份有限公司 | Bismuth-containing burn dressing and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040156873A1 (en) * | 2003-02-10 | 2004-08-12 | Gupta Shyam K. | Topically Bioavailable Acne and Rosacea Treatment Compositions |
| CN102552964A (en) * | 2012-01-09 | 2012-07-11 | 青岛明药堂医药科技开发有限公司 | Nano silver chitosan composite antibacterial composition, adhesive bandage and preparation method of adhesive bandage |
| CN104473809A (en) * | 2014-11-26 | 2015-04-01 | 青岛市市南区隆德中医药研究所 | Skin care solution and preparation method thereof |
| CN104667334A (en) * | 2015-03-24 | 2015-06-03 | 深圳市源兴纳米医药科技有限公司 | Foam dressing containing composite silver-zinc antibacterial material and preparation method of foam dressing |
| CN105431176A (en) * | 2013-05-30 | 2016-03-23 | 医疗行业产品有限公司 | Degradable haemostat composition |
-
2018
- 2018-12-06 CN CN201811489303.9A patent/CN109432481A/en not_active Withdrawn
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040156873A1 (en) * | 2003-02-10 | 2004-08-12 | Gupta Shyam K. | Topically Bioavailable Acne and Rosacea Treatment Compositions |
| CN102552964A (en) * | 2012-01-09 | 2012-07-11 | 青岛明药堂医药科技开发有限公司 | Nano silver chitosan composite antibacterial composition, adhesive bandage and preparation method of adhesive bandage |
| CN105431176A (en) * | 2013-05-30 | 2016-03-23 | 医疗行业产品有限公司 | Degradable haemostat composition |
| CN104473809A (en) * | 2014-11-26 | 2015-04-01 | 青岛市市南区隆德中医药研究所 | Skin care solution and preparation method thereof |
| CN104667334A (en) * | 2015-03-24 | 2015-06-03 | 深圳市源兴纳米医药科技有限公司 | Foam dressing containing composite silver-zinc antibacterial material and preparation method of foam dressing |
Non-Patent Citations (1)
| Title |
|---|
| DENISA FICAI等: "Manufacturing nanostructured chitosan-based 2D sheets with prolonged antimicrobial activity", 《ROM J MORPHOL EMBRYOL》 * |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109880052A (en) * | 2019-03-20 | 2019-06-14 | 亳州科蔚科技服务有限公司 | A kind of medical bandage coating preparation method of polyurethane resin compound material |
| TWI733144B (en) * | 2019-07-22 | 2021-07-11 | 中鎮醫療產品科技股份有限公司 | Water glue for scar film and its preparation method |
| CN112266455A (en) * | 2020-09-29 | 2021-01-26 | 万华化学集团股份有限公司 | Modified high blood absorption polyurethane sponge, preparation method and application thereof |
| CN113041389A (en) * | 2021-05-06 | 2021-06-29 | 南昌智产科技有限公司 | Medical dressing of antibiotic hydrophilic polyurethane foam |
| CN113713163A (en) * | 2021-09-09 | 2021-11-30 | 武汉理工大学 | Hydrophilic polyurethane dressing and preparation method thereof |
| CN113754853A (en) * | 2021-09-14 | 2021-12-07 | 武汉理工大学 | Antibacterial medical drainage polyurethane foam and preparation method thereof |
| CN114306721A (en) * | 2022-01-12 | 2022-04-12 | 河北卫崭医疗科技有限公司 | Waterproof and breathable foam dressing and preparation method thereof |
| CN114848884A (en) * | 2022-05-17 | 2022-08-05 | 山东万容生物科技有限公司 | Polyurethane foam dressing and preparation method thereof |
| CN114848884B (en) * | 2022-05-17 | 2023-08-04 | 山东万容生物科技有限公司 | Polyurethane foam dressing and preparation method thereof |
| CN116672488A (en) * | 2023-07-17 | 2023-09-01 | 泰州市榕兴医疗用品股份有限公司 | Bismuth-containing burn dressing and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN109432481A (en) | A kind of polyurethane dressing of hemostatic and antibacterial and preparation method thereof | |
| Rezvani Ghomi et al. | Wound dressings: Current advances and future directions | |
| CN103520764B (en) | Functional dressing, and preparation method and application thereof | |
| CN105107008B (en) | A kind of hydroxyl butyl chitosan/oxidized sodium alginate/nano silver composite hydrogel dressing patch | |
| CN107029272A (en) | A kind of alginate medical dressing and preparation method thereof | |
| CN102670929B (en) | Composite for injury healing and preparing method thereof | |
| CN104623718B (en) | Chitosan petrolatum gauze and preparation method thereof | |
| CN104758977A (en) | An alginate dressing for treating bedsore and a preparing method thereof | |
| CN107617121B (en) | Biological induction active dressing for skin wound surface and preparation method and application thereof | |
| CN107185031A (en) | A kind of medical dressing with bioactivity and preparation method thereof | |
| CN115124738B (en) | Double-layer bionic drug-loaded hydrogel and preparation and application thereof | |
| CN103263434A (en) | Anti-adhesion liquor for wound washing and surgery and preparation method and application of anti-adhesion liquor | |
| CN106110383A (en) | A kind of chitosan alginate dressing and freeze-drying process thereof | |
| CN111481735A (en) | Medical antibacterial wound-protecting hydrogel dressing and preparation method thereof | |
| CN104771779B (en) | A kind of functional dressings and preparation method thereof | |
| CN104306324A (en) | Medical collagen gel and preparation method thereof | |
| CN104474573A (en) | Biological mask and preparation method thereof | |
| CN100540066C (en) | Medical chitosan dressing and production method thereof | |
| CN104740141B (en) | A kind of antimicrobial spray and preparation method thereof | |
| CN112587655B (en) | Aloe arborescens-chitosan-graphene oxide gel freeze-dried powder for burns | |
| CN111166932B (en) | Liquid wound spray dressing and preparation method thereof | |
| CN111012945A (en) | Novel waterproof traditional Chinese medicine liquid band-aid and preparation method thereof | |
| CN107595819B (en) | A kind of Nano diamond modified liquid adhesive bandage and preparation method thereof | |
| CN109010907B (en) | A kind of functionality Wound-protection liquid body dressing and preparation method thereof | |
| CN110869062A (en) | Film for topical application in the treatment of skin lesions and method for obtaining and applying same |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20190308 |
|
| WW01 | Invention patent application withdrawn after publication |