CN109331045A - It is a kind of containing Bee Pollen, the probiotic composition of active carbon and preparation method thereof - Google Patents
It is a kind of containing Bee Pollen, the probiotic composition of active carbon and preparation method thereof Download PDFInfo
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- CN109331045A CN109331045A CN201811404691.6A CN201811404691A CN109331045A CN 109331045 A CN109331045 A CN 109331045A CN 201811404691 A CN201811404691 A CN 201811404691A CN 109331045 A CN109331045 A CN 109331045A
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- active carbon
- bee pollen
- powder
- probiotic
- lactobacillus
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- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 title claims abstract description 97
- 229910052799 carbon Inorganic materials 0.000 title claims abstract description 96
- 239000006041 probiotic Substances 0.000 title claims abstract description 78
- 235000018291 probiotics Nutrition 0.000 title claims abstract description 78
- 239000000203 mixture Substances 0.000 title claims abstract description 60
- 230000000529 probiotic effect Effects 0.000 title claims abstract description 55
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 239000000843 powder Substances 0.000 claims abstract description 61
- 239000000463 material Substances 0.000 claims abstract description 32
- 241000894006 Bacteria Species 0.000 claims abstract description 12
- 241000186000 Bifidobacterium Species 0.000 claims description 19
- 239000003610 charcoal Substances 0.000 claims description 18
- 230000000694 effects Effects 0.000 claims description 18
- 238000001035 drying Methods 0.000 claims description 17
- 240000001046 Lactobacillus acidophilus Species 0.000 claims description 12
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 claims description 12
- 229940039695 lactobacillus acidophilus Drugs 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 230000001954 sterilising effect Effects 0.000 claims description 9
- 238000004659 sterilization and disinfection Methods 0.000 claims description 9
- 241000186660 Lactobacillus Species 0.000 claims description 7
- 235000013325 dietary fiber Nutrition 0.000 claims description 7
- 229940039696 lactobacillus Drugs 0.000 claims description 7
- 241000196324 Embryophyta Species 0.000 claims description 6
- 241001465754 Metazoa Species 0.000 claims description 6
- 229940038481 bee pollen Drugs 0.000 claims description 6
- 235000013336 milk Nutrition 0.000 claims description 6
- 239000008267 milk Substances 0.000 claims description 6
- 210000004080 milk Anatomy 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 229920002774 Maltodextrin Polymers 0.000 claims description 5
- 239000005913 Maltodextrin Substances 0.000 claims description 5
- 229920002472 Starch Polymers 0.000 claims description 5
- 239000002775 capsule Substances 0.000 claims description 5
- 239000012043 crude product Substances 0.000 claims description 5
- 229940035034 maltodextrin Drugs 0.000 claims description 5
- 235000019698 starch Nutrition 0.000 claims description 5
- 239000008107 starch Substances 0.000 claims description 5
- 235000017166 Bambusa arundinacea Nutrition 0.000 claims description 4
- 235000017491 Bambusa tulda Nutrition 0.000 claims description 4
- 241000901050 Bifidobacterium animalis subsp. lactis Species 0.000 claims description 4
- 241000186016 Bifidobacterium bifidum Species 0.000 claims description 4
- 240000001548 Camellia japonica Species 0.000 claims description 4
- 244000060011 Cocos nucifera Species 0.000 claims description 4
- 235000013162 Cocos nucifera Nutrition 0.000 claims description 4
- 240000001008 Dimocarpus longan Species 0.000 claims description 4
- 244000166124 Eucalyptus globulus Species 0.000 claims description 4
- 235000000235 Euphoria longan Nutrition 0.000 claims description 4
- 244000199885 Lactobacillus bulgaricus Species 0.000 claims description 4
- 235000013960 Lactobacillus bulgaricus Nutrition 0.000 claims description 4
- 244000199866 Lactobacillus casei Species 0.000 claims description 4
- 235000013958 Lactobacillus casei Nutrition 0.000 claims description 4
- 241000218588 Lactobacillus rhamnosus Species 0.000 claims description 4
- 241000228347 Monascus <ascomycete fungus> Species 0.000 claims description 4
- 244000082204 Phyllostachys viridis Species 0.000 claims description 4
- 235000015334 Phyllostachys viridis Nutrition 0.000 claims description 4
- 240000008670 Pinus densiflora Species 0.000 claims description 4
- 235000000405 Pinus densiflora Nutrition 0.000 claims description 4
- 240000007263 Pinus koraiensis Species 0.000 claims description 4
- 235000011615 Pinus koraiensis Nutrition 0.000 claims description 4
- 241000235342 Saccharomycetes Species 0.000 claims description 4
- 241000194020 Streptococcus thermophilus Species 0.000 claims description 4
- 239000011425 bamboo Substances 0.000 claims description 4
- 229940002008 bifidobacterium bifidum Drugs 0.000 claims description 4
- 229940009289 bifidobacterium lactis Drugs 0.000 claims description 4
- 235000018597 common camellia Nutrition 0.000 claims description 4
- 239000000835 fiber Substances 0.000 claims description 4
- 239000010903 husk Substances 0.000 claims description 4
- 229940004208 lactobacillus bulgaricus Drugs 0.000 claims description 4
- 229940017800 lactobacillus casei Drugs 0.000 claims description 4
- 241000193830 Bacillus <bacterium> Species 0.000 claims description 3
- 241000186018 Bifidobacterium adolescentis Species 0.000 claims description 3
- 241000186015 Bifidobacterium longum subsp. infantis Species 0.000 claims description 3
- 241000628997 Flos Species 0.000 claims description 3
- 241000186869 Lactobacillus salivarius Species 0.000 claims description 3
- 229940004120 bifidobacterium infantis Drugs 0.000 claims description 3
- 238000001291 vacuum drying Methods 0.000 claims description 3
- 241000186605 Lactobacillus paracasei Species 0.000 claims description 2
- 239000006071 cream Substances 0.000 claims description 2
- 238000010348 incorporation Methods 0.000 claims description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract description 12
- 206010010774 Constipation Diseases 0.000 abstract description 10
- 230000000968 intestinal effect Effects 0.000 abstract description 8
- 206010012735 Diarrhoea Diseases 0.000 abstract description 6
- 230000009286 beneficial effect Effects 0.000 abstract description 5
- 230000002040 relaxant effect Effects 0.000 abstract description 3
- 238000011282 treatment Methods 0.000 abstract description 3
- 238000010521 absorption reaction Methods 0.000 abstract description 2
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 8
- 230000002401 inhibitory effect Effects 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- 244000052616 bacterial pathogen Species 0.000 description 5
- 230000001580 bacterial effect Effects 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 235000014655 lactic acid Nutrition 0.000 description 4
- 239000004310 lactic acid Substances 0.000 description 4
- 239000003053 toxin Substances 0.000 description 4
- 231100000765 toxin Toxicity 0.000 description 4
- 238000009395 breeding Methods 0.000 description 3
- 230000001488 breeding effect Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 231100000614 poison Toxicity 0.000 description 3
- 230000007096 poisonous effect Effects 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 241000186012 Bifidobacterium breve Species 0.000 description 2
- 230000003385 bacteriostatic effect Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 201000006549 dyspepsia Diseases 0.000 description 2
- 230000008030 elimination Effects 0.000 description 2
- 238000003379 elimination reaction Methods 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- 230000001473 noxious effect Effects 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 241001608472 Bifidobacterium longum Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 208000007882 Gastritis Diseases 0.000 description 1
- 240000006024 Lactobacillus plantarum Species 0.000 description 1
- 235000013965 Lactobacillus plantarum Nutrition 0.000 description 1
- 240000002853 Nelumbo nucifera Species 0.000 description 1
- 235000006508 Nelumbo nucifera Nutrition 0.000 description 1
- 235000006510 Nelumbo pentapetala Nutrition 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 230000001142 anti-diarrhea Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 229940009291 bifidobacterium longum Drugs 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 150000001722 carbon compounds Chemical class 0.000 description 1
- 239000003575 carbonaceous material Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000013872 defecation Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 210000003736 gastrointestinal content Anatomy 0.000 description 1
- 230000005176 gastrointestinal motility Effects 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 208000002551 irritable bowel syndrome Diseases 0.000 description 1
- 229940072205 lactobacillus plantarum Drugs 0.000 description 1
- 238000009630 liquid culture Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/44—Elemental carbon, e.g. charcoal, carbon black
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/745—Bifidobacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/064—Saccharomycetales, e.g. baker's yeast
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- Organic Chemistry (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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Abstract
The invention discloses a kind of containing Bee Pollen, the probiotic composition of active carbon and preparation method thereof, belongs to probiotics field.The composition includes following materials in percentage by mass: probiotic powder 1%-50%, Bee Pollen 1%-40%, active carbon 0.1%-0.5% and auxiliary material 9.5%-97.9%.The present invention is that will have the probiotics powder agent for adjusting function of intestinal canal, have the Bee Pollen of facilitation with function of relaxing bowel and to growth of probiotics and have the active carbon of absorption harmful intestinal tract material function is combined to form.A kind of probiotic composition beneficial bacterium, Bee Pollen and active carbon provided by the invention cooperate, and are effectively improved intestinal microecology, are beneficial to constipation, diarrhea and dyspeptic alleviation and treatment.
Description
Technical field
The invention belongs to probiotics fields, and in particular to it is a kind of containing Bee Pollen, active carbon probiotic composition and
Preparation method.
Background technique
With the quickening of modern life rhythm, the pressure of people's life increases, stays up late, having a sleepless night and largely taking antibiolics
The factors such as object make many people digestive system imbalance usually occur, cause the situations such as constipation, indigestion, so as to cause disease
Occur.It is blindly easy to further result in again using antibiotic medicine in gastrointestinal tract and the flora that human health cuts much ice is lost
Weighing apparatus, therefore, very little can be negatively affected to human gastrointestinal tract flora by developing one kind, and can quickly eliminate constipation and digestion not
The product of good situation has great importance.
Probiotics is a kind of microorganism beneficial to human gastrointestinal tract, mainly has lactobacillus and Bifidobacterium etc., it takes the photograph
Enter the metabolism that can change the structure of autochthonous flora or influence intestinal flora in enteron aisle.Probiotics mainly pass through field planting, occupy-place,
Nutrition and antagonism mode are fought for, breeding of the harmful microorganism in enteron aisle is inhibited or weaken, balance intestinal Tiny ecosystem reaches healing
Or alleviate a variety of enteron aisles or enteron aisle related disease, such as diarrhea, constipation and irritable bowel syndrome etc..Currently, having developed both at home and abroad
Many probiotics health products out, commercially available major part probiotics generate one or more of special functions substantially all to host
By demonstration.Largely researches show that probiotics to facilitate many disease treatments, including improves diarrhea, constipation and improve itself
Immunity etc. but it is different specific strain efficacy and different.
Bee Pollen is a kind of containing there are many sugar, enzyme, organic acid, amino acid, unsaturated fatty acid, nucleic acid and minerals etc.
Natural products.Contain a large amount of glucide in Bee Pollen, is conducive to the growth of beneficial bacteria of intestinal tract.In Bee Pollen it is a variety of at
Point, there is high medical value, have the function of promoting gastrointestinal motility, relax bowel and defecation.Therefore, can be used for various types of
Constipation.But the independent eating mouth feel of Bee Pollen is poor.
Active carbon is a kind of carbonaceous material containing a large amount of micropores, has extremely strong suction-operated.Orally active charcoal can
Pass through the metabolite accumulation noxious material in absorption enteron aisle, stink substances, external source noxious material, toxin, virus and the nocuousness eaten by mistake
Microorganism etc., excretes with excrement and is not absorbed in gastrointestinal tract so that more cleaned in enteron aisle, conducive to probiotics competition and
Field planting, to reach the function of adjusting gastrointestinal tract.Active carbon gastritis, indigestion and in terms of have adjusting digestive function
Effect, while there is functions of expelling toxin.Orally active charcoal can reduce stimulation of the intestinal contents to intestinal wall, so that enterocinesia is reduced,
Have the function that antidiarrheal, to absorbed poisonous substance, the removing of poisonous substance can be accelerated.But the stomach that a large amount of Orally active charcoals generate is not
Constipation side effect is accommodated, keeps its application limited.
Probiotics compound is increasingly valued by people in recent years, it has also become improves human gastrointestinal tract microecosystem
Important means, not sick diseases prevention has become a kind of normality, and either healthy people, diarrhea patient or constipation patient can take
With.Probiotics with many kinds of substance is compound can play coordination facilitation, there is the probiotics for adjusting intestinal flora balance and tool
There is the Bee Pollen of function of relaxing bowel that can avoid list well with the active carbon combination that can adsorb various poisonous substances in gastrointestinal tract
The defect solely used more effectively acts synergistically.
Summary of the invention
Present invention aims to overcome that deficiency in the prior art, provides a kind of probiotic group containing Bee Pollen, active carbon
Object and preparation method thereof is closed, is able to solve constipation, diarrhea problem, while promoting enteral nutrition material absorbing and functions of expelling toxin.
To achieve the above object, the present invention adopts the following technical scheme:
A kind of probiotic composition containing Bee Pollen, active carbon includes following raw material: probiotic powder, Bee Pollen, active carbon and auxiliary
Help raw material.
A kind of probiotic composition containing Bee Pollen, active carbon includes following materials in percentage by mass: probiotic powder 1%-
50%, Bee Pollen 1%-40%, active carbon 0.1%-0.5%, auxiliary material 9.5%-97.9%.
Further, probiotics is one of Bifidobacterium, lactobacillus, streptococcus thermophilus, saccharomycete, Monascus or several
Kind.
Further, Bifidobacterium includes animal bifidobacteria, bifidobacterium lactis, long Bifidobacterium Bifidum, baby's bifid bar
One or more of bacterium, bifidobacterium adolescentis, bifidobacterium breve；The lactobacillus is lactobacillus acidophilus, Lactobacillus casei, pair
One or more of Lactobacillus casei, lactobacillus plantarum, Lactobacillus salivarius, lactobacillus bulgaricus, Lactobacillus rhamnosus.
Further, the probiotic powder is viable bacteria, total viable count >=108 cfu/g。
Further, Bee Pollen includes bee pollen form cole, camellia Bee Pollen, lichee Bee Pollen, longan Bee Pollen, lotus bee
One or more of pollen.
Further, active carbon includes the bamboo charcoal powder that can be eaten, Korean pine charcoal powder, coconut husk powdered carbon, Eucalyptus powdered carbon, oak charcoal
One of powder, Japanese red pine charcoal powder, plant fiber powdered carbon, shell powdered carbon are several.
Further, auxiliary material includes one or more of maltodextrin, converted starch, dietary fiber, milk powder.
Further, the form of probiotic composition includes pulvis or capsule.
A kind of preparation method containing Bee Pollen, the probiotic composition of active carbon, includes the following steps:
(1) pretreatment of Bee Pollen: peak pollen is crossed 60 ~ 80 meshes after being mechanically pulverized, is utilized606 kGy dosage of Co- gamma-rays
Irradiation sterilization is carried out, under sterile conditions rapidly turns to irradiation sample in vacuum oven, 45~55 DEG C of drying 25~
35min, makes moisture content≤5wt%, and water activity≤0.2 is spare；
(2) pretreatment of auxiliary material: auxiliary material utilizes606 kGy dosage of Co- gamma-rays carries out irradiation sterilization, sterile
Under the conditions of irradiation sample is rapidly turned in vacuum oven, and in 45~55 DEG C of 25~35min of drying, make moisture content≤
5wt%, water activity≤0.2 are spare；
(3) pretreatment of active carbon: active carbon utilizes606 kGy dosage of Co- gamma-rays carries out irradiation sterilization, in sterile condition
It is lower to rapidly turn to irradiation sample in vacuum oven, and in 45~55 DEG C of 25~35min of drying, make moisture content≤
5wt%, water activity≤0.2 are spare；
(4) the pre- mixing of probiotic powder: required probiotic powder is weighed in proportion, and weighed probiotic powder is placed in powder and is mixed
10min~20min is mixed in conjunction machine；
(5) it is proportionally added into step (2) pretreated auxiliary material in the probiotic powder of step (4) preparation, it is mixed in powder
15min~35min is carried out in conjunction machine to mix well；Then add pretreated Bee Pollen in people's step (1) in proportion, it is mixed in powder
15min~35min is carried out in conjunction machine to mix well；It is proportionally added into step (3) pretreated active carbon again, in powder mixer
Middle progress 15min~35min is mixed well, and can be obtained powder composition；
(6) it is dried in vacuo: the composition crude product that step (5) obtain is carried out under the conditions of 4 ~ 28 DEG C, vacuum drying 5min~
25min；
(7) composition of powdery or capsule form is made in the sample after drying.
Further, in step (1) Bee Pollen in 50 DEG C of drying 30min.
Further, in step (2) active carbon in 50 DEG C of drying 30min.
Further, in step (3) auxiliary material in 50 DEG C of drying 30min.
Further, weighed probiotic powder is placed in powder mixer in step (4) and mixes 15min.
Further, incorporation time is all 20min in step (5).
Further, in step (6), to step (5) obtain composition crude product under the conditions of 25 DEG C, vacuum drying
20min。
The present invention has the advantages that
Composition of the invention is by with the probiotics for adjusting intestinal flora balance effect and the bee with function of relaxing bowel
Pollen and active carbon with absorbing toxin gut purge function are composed.Growth of the Bee Pollen to probiotics contained by the present invention
With facilitation；Active carbon can remove harmful intestinal tract substance；Bee Pollen and active carbon and probiotics act synergistically, and are effectively improved
Intestine microenvironment and achieve the purpose that prevent and treat intestines problem, be beneficial to constipation, diarrhea and dyspeptic alleviation and treatment.
Specific embodiment
Below by specific embodiment, the present invention is described in further detail
The influence that 1 Bee Pollen of embodiment, active carbon respectively grow Bifidobacterium and lactobacillus acidophilus in Liquid Culture
Strain bifidobacterium and lactobacillus acidophilus are inoculated into the active carbon of percent concentration containing different quality or Bee Pollen respectively
In lactic acid bacteria fluid nutrient medium, 37 DEG C of Anaerobic culturel 28h.Bacterium solution 10 is serially diluted again, selects 10-4~10-7Four dilutions
Degree is inoculated into respectively on lactic acid bacteria solid medium, continues 37 DEG C of Anaerobic culturel 48h, number plate viable count, with blank control
The viable count of middle flourish is 100%, calculates the breeding viable count in different quality percent concentration active carbon or Bee Pollen
Growth rate (table 1).
The influence that 1 Bee Pollen of table, active carbon grow different Bifidobacteriums and lactobacillus acidophilus
The result shows that in a liquid state, Bee Pollen has facilitation to the growth of lactobacillus acidophilus, Bifidobacterium；Quality
Active carbon within percentage 0.5% has facilitation to the growth of newborn Bifidobacterium Bifidum；And mass percent 0.25% and 0.5% is active
Charcoal has inhibiting effect to lactobacillus acidophilus and animal bifidobacteria, and wherein the active carbon of mass percent 0.1% is to these bacterial strains
Inhibiting effect is unobvious.
What 2 Bee Pollen of embodiment and active carbon combination in liquid medium grew Bifidobacterium and lactobacillus acidophilus
It influences
According to embodiment 1, select the Bee Pollen of mass percent 0.25%, 0.5%, respectively with mass percent 0.1%, 0.25%
Active carbon with 0.5% combines, and is added in lactic acid bacteria culture solution, 37 DEG C of Anaerobic culturel 28h.Bacterium solution 10 is serially diluted again,
Selection 10-4~10-7Four dilutions are inoculated into respectively on lactic acid bacteria solid medium, continue 37 DEG C of Anaerobic culturel 48h, number
Plate viable count, with the viable count of flourish in blank control be 100%, calculate different quality percent concentration active carbon or
The growth rate (table 2) of breeding viable count in Bee Pollen.
The influence that 2 Bee Pollen of table and active carbon combination grow different Bifidobacteriums and lactobacillus acidophilus
The result shows that in a liquid state, Bee Pollen is combined with active carbon, it to a certain degree being capable of suppression of the elimination activity charcoal to bacterial strain
Production is used, wherein the composition of the active carbon of mass percent 0.1% and the Bee Pollen of mass percent 0.5%, elimination activity charcoal
It is obvious to the effect of bacterial strain inhibiting effect.Show that active carbon is combined with Bee Pollen, active carbon can be effectively eliminated, bacterial strain is inhibited to make
With to realize that Bee Pollen can promote the growth of probiotics；Active carbon can remove harmful intestinal tract substance, and collaboration between the two is made
With.
Probiotic composition of the embodiment 3 containing Bee Pollen, active carbon
A kind of probiotic composition containing Bee Pollen, active carbon includes following raw material: probiotic powder, Bee Pollen, active carbon and auxiliary
Help raw material.Wherein probiotic powder is one or more of Bifidobacterium, lactobacillus, streptococcus thermophilus, saccharomycete, Monascus；
The Bifidobacterium is animal bifidobacteria, bifidobacterium lactis, long Bifidobacterium Bifidum, bifidobacterium infantis, bifidobacterium adolescentis, short
One or more of Bifidobacterium；The lactobacillus is lactobacillus acidophilus, Lactobacillus casei, lactobacillus paracasei, plant cream
One or more of bacillus, Lactobacillus salivarius, lactobacillus bulgaricus, Lactobacillus rhamnosus；Bee Pollen be bee pollen form cole,
One of camellia Bee Pollen, lichee Bee Pollen, longan Bee Pollen, Flos Nelumbinis pollen are several.Active carbon is that can eat
Bamboo charcoal powder, Korean pine charcoal powder, coconut husk powdered carbon, Eucalyptus powdered carbon, oak powdered carbon, Japanese red pine charcoal powder, plant fiber powdered carbon, fruit shell carbon
One of powder is several；Auxiliary material is one of maltodextrin, converted starch, dietary fiber, milk powder or several.
Concrete composition is as follows:
Probiotic composition A containing Bee Pollen, active carbon: including following materials in percentage by mass: animal bifidobacteria (1011
Cfu/g) 10%, bee pollen form cole 40%, bamboo charcoal powder 0.25%, converted starch 35% and dietary fiber 14.75%.
Probiotic composition B containing Bee Pollen, active carbon: including following materials in percentage by mass: bifidobacterium lactis (1011
Cfu/g) 10%, lactobacillus acidophilus (1011Cfu/g) 10%, bee pollen form cole 30%, Korean pine charcoal powder 0.25%, maltodextrin
29.75% and dietary fiber 20%.
Probiotic composition C containing Bee Pollen, active carbon: including following materials in percentage by mass: animal bifidobacteria
(1011Cfu/g) 5%, lactobacillus acidophilus (1011Cfu/g) 5 %, bee pollen form cole 40%, coconut husk powdered carbon 0.25% and milk powder
39.75%。
Probiotic composition D containing Bee Pollen, active carbon: including following materials in percentage by mass: bifidobacterium breve (1011
Cfu/g) 5%, Monascus 5%, camellia Bee Pollen 40%, Eucalyptus powdered carbon 0.25%, converted starch 35% and dietary fiber
14.75%。
Probiotic composition E containing Bee Pollen, active carbon: including following materials in percentage by mass: bifidobacterium longum (1011
Cfu/g) 10%, lactobacillus bulgaricus (1011Cfu/g) 10%, lichee peak pollen 30%, oak powdered carbon 0.25%, maltodextrin
29.75% and dietary fiber 20%.
Probiotic composition F containing Bee Pollen, active carbon: including following materials in percentage by mass: including following quality hundred
Divide than raw material: bifidobacterium infantis (1011Cfu/g) 5%, Lactobacillus rhamnosus (1011Cfu/g) 5 %, longan Bee Pollen 40%,
Japanese red pine charcoal powder 0.25% and milk powder 39.75%.
Probiotic composition G containing Bee Pollen, active carbon: including following materials in percentage by mass: streptococcus thermophilus (1011
Cfu/g) 5%, saccharomycete (1011Cfu/g) 5 %, Flos Nelumbinis pollen 40%, plant fiber powdered carbon 0.25% and milk powder 39.75%.
A kind of preparation method containing Bee Pollen, active carbon and the composition of probiotics of embodiment 4
Composition in embodiment 3, is prepared in the following manner:
(1) pretreatment of Bee Pollen: peak pollen is crossed 60 meshes after being mechanically pulverized, is utilized606 kGy dosage of Co- gamma-rays carries out
Irradiation sterilization under sterile conditions rapidly turns to irradiation sample in vacuum oven, and in 50 DEG C of drying 30min, makes water
Divide content 5wt%, water activity 0.2 is spare；
(2) pretreatment of auxiliary material: auxiliary material utilizes606 kGy dosage of Co- gamma-rays carries out irradiation sterilization, sterile
Under the conditions of irradiation sample is rapidly turned in vacuum oven, and in 50 DEG C of drying 30min, make moisture content 5wt%, water activity
0.2, it is spare；
(3) pretreatment of active carbon: active carbon utilizes606 kGy dosage of Co- gamma-rays carries out irradiation sterilization, in sterile condition
It is lower to rapidly turn to irradiation sample in vacuum oven, and in 50 DEG C of drying 30min, make moisture content 5wt%, water activity 0.2,
It is spare；
(4) the pre- mixing of probiotic powder: required probiotic powder is weighed in proportion, and weighed probiotic powder is placed in powder and is mixed
15min is mixed in conjunction machine；
(5) it is proportionally added into step (2) pretreated auxiliary material in the probiotic powder of step (4) preparation, is mixed in powder
20min is carried out in machine to mix well；Then in proportion plus people's step (1) in pretreated Bee Pollen, in powder mixer into
Row 20min is mixed well；It is proportionally added into step (3) pretreated active carbon again, it is abundant that 20min is carried out in powder mixer
It mixes, can be obtained powder composition；
(6) it is dried in vacuo: under the conditions of 25 DEG C of composition crude product of step (5) acquisition, being dried in vacuo 20min.
(7) after drying, powdery is made in composition A, B, C, D, and capsule form is made in composition E, F.
Stability test of the embodiment 5 containing Bee Pollen, active carbon and probiotic composition
Investigate the viable count stability of their 4 DEG C of storage different times respectively to composition A, B and C prepared by embodiment 4,
It the results are shown in Table 3.
Table 3 containing in Bee Pollen, active carbon compound probiotic composition number of viable (, n=10)
The result shows that the viable count variation in composition A, composition B and composition C is not significant within 24 months
(P > 0.05), is basically unchanged, excellent in stability.Show that Bee Pollen and active carbon have no adverse effects to the activity of probiotics, three
Between can exist simultaneously, collaboration plays a role.
Antimicrobial test of the embodiment 6 containing Bee Pollen, the probiotic composition of active carbon
Composition A, B and the C prepared to embodiment 4 investigates their In Vitro Bacteriostatic respectively, while investigating Bee Pollen
With active carbon itself to the bacteriostasis of pathogenic bacteria, it the results are shown in Table 4.
The In Vitro Bacteriostatic of 4 composition of table
Note :-indicate not act on
The result shows that active carbon has inhibiting effect to three kinds of pathogenic bacteria；And Bee Pollen then makees the equal unrestraint of three kinds of pathogenic bacteria
With；Inhibiting effect after active carbon and Bee Pollen combination is changed with individually with the effect of active carbon unobvious；But composition A,
Composition B and composition C has the inhibiting effect of three kinds of staphylococcus aureus, salmonella and Escherichia coli pathogenic bacteria
Increased.Therefore, Bee Pollen, active carbon and probiotics form composition, have inhibiting effect, Neng Gouda to pathogenic bacteria in enteron aisle
To the effect for adjusting intestinal flora.
The foregoing is merely presently preferred embodiments of the present invention, all equivalent changes done according to scope of the present invention patent with
Modification, is all covered by the present invention.
Claims (10)
1. a kind of probiotic composition containing Bee Pollen, active carbon, which is characterized in that include following raw material: probiotic powder, melissa
Powder, active carbon and auxiliary material.
2. a kind of probiotic composition containing Bee Pollen, active carbon according to claim 1, which is characterized in that include
Following materials in percentage by mass: probiotic powder 1%-50%, Bee Pollen 1%-40%, active carbon 0.1%-0.5%, auxiliary material
9.5%-97.9%。
3. a kind of probiotic composition containing Bee Pollen, active carbon according to claim 1, it is characterised in that: described
Probiotics includes one or more of Bifidobacterium, lactobacillus, streptococcus thermophilus, saccharomycete, Monascus.
4. a kind of probiotic composition containing Bee Pollen, active carbon according to claim 2, it is characterised in that: described double
Discrimination bacillus includes animal bifidobacteria, bifidobacterium lactis, long Bifidobacterium Bifidum, bifidobacterium infantis, bifidobacterium adolescentis, short bifid
One or more of bacillus；The lactobacillus includes lactobacillus acidophilus, Lactobacillus casei, lactobacillus paracasei, plant cream bar
One or more of bacterium, Lactobacillus salivarius, lactobacillus bulgaricus, Lactobacillus rhamnosus；The probiotics is viable bacteria, total
Viable count >=108 cfu/g。
5. a kind of probiotic composition containing Bee Pollen, active carbon according to claim 1, it is characterised in that: described
Bee Pollen includes one of bee pollen form cole, camellia Bee Pollen, lichee Bee Pollen, longan Bee Pollen, Flos Nelumbinis pollen or several
Kind.
6. a kind of probiotic composition containing Bee Pollen, active carbon according to claim 1, it is characterised in that: described
Active carbon include the bamboo charcoal powder that can be eaten, Korean pine charcoal powder, coconut husk powdered carbon, Eucalyptus powdered carbon, oak powdered carbon, Japanese red pine charcoal powder,
One of plant fiber powdered carbon, shell powdered carbon are several.
7. a kind of probiotic composition containing Bee Pollen, active carbon according to claim 1, it is characterised in that: described
Auxiliary material includes one or more of maltodextrin, converted starch, dietary fiber, milk powder.
8. a kind of probiotic composition containing Bee Pollen, active carbon according to claim 1, it is characterised in that: described
The form of probiotic composition includes pulvis or capsule.
9. a kind of preparation method containing Bee Pollen, the probiotic composition of active carbon as described in claim 1, feature exist
In including the following steps:
(1) pretreatment of Bee Pollen: peak pollen is crossed 60 ~ 80 meshes after being mechanically pulverized, is utilized606 kGy dosage of Co- gamma-rays into
Row irradiation sterilization, under sterile conditions rapidly turns to irradiation sample in vacuum oven, and dries 25 at 45~55 DEG C
~35min, makes moisture content≤5wt%, and water activity≤0.2 is spare；
(2) pretreatment of auxiliary material: auxiliary material utilizes606 kGy dosage of Co- gamma-rays carries out irradiation sterilization, sterile
Under the conditions of irradiation sample is rapidly turned in vacuum oven, and in 45~55 DEG C of 25~35min of drying, make moisture content≤
5wt%, water activity≤0.2 are spare；
(3) pretreatment of active carbon: active carbon utilizes606 kGy dosage of Co- gamma-rays carries out irradiation sterilization, in sterile condition
It is lower to rapidly turn to irradiation sample in vacuum oven, and in 45~55 DEG C of 25~35min of drying, make moisture content≤
5wt%, water activity≤0.2 are spare；
(4) the pre- mixing of probiotic powder: required probiotic powder is weighed in proportion, and weighed probiotic powder is placed in powder and is mixed
10min~20min is mixed in conjunction machine；
(5) it is proportionally added into step (2) pretreated auxiliary material in the probiotic powder of step (4) preparation, is mixed in powder
15min~35min is carried out in machine to mix well；Then add pretreated Bee Pollen in people's step (1) in proportion, mixed in powder
15min~35min is carried out in machine to mix well；Enter step (3) pretreated active carbon again plus in proportion, in powder mixer
It carries out 15min~35min to mix well, can be obtained powder composition；
(6) it is dried in vacuo: the composition crude product that step (5) obtain is carried out under the conditions of 4 ~ 28 DEG C, vacuum drying 5min~
25min；
(7) composition of powdery or capsule form is made in the sample after drying.
10. a kind of preparation method containing Bee Pollen, the probiotic composition of active carbon according to claim 9, feature
Be: Bee Pollen is in 50 DEG C of drying 30min in step (1)；Active carbon is in 50 DEG C of drying 30min in step (2)；In step (3)
Auxiliary material is in 50 DEG C of drying 30min；Weighed probiotic powder is placed in powder mixer in step (4) and mixes 15min；Step
Suddenly incorporation time is all 20min in (5)；In step (6), to step (5) obtain composition crude product under the conditions of 25 DEG C, vacuum
Dry 20min.
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