CN109157228A - Blood collection tube for instant serum separation - Google Patents
Blood collection tube for instant serum separation Download PDFInfo
- Publication number
- CN109157228A CN109157228A CN201810671755.2A CN201810671755A CN109157228A CN 109157228 A CN109157228 A CN 109157228A CN 201810671755 A CN201810671755 A CN 201810671755A CN 109157228 A CN109157228 A CN 109157228A
- Authority
- CN
- China
- Prior art keywords
- tube body
- tube
- serum
- plug
- blood
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000002966 serum Anatomy 0.000 title claims abstract description 41
- 238000000926 separation method Methods 0.000 title claims abstract description 21
- 210000004369 blood Anatomy 0.000 title abstract description 32
- 239000008280 blood Substances 0.000 title abstract description 32
- 239000012528 membrane Substances 0.000 claims abstract description 17
- 238000010241 blood sampling Methods 0.000 claims abstract description 5
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 14
- 229960002897 heparin Drugs 0.000 claims description 14
- 229920000669 heparin Polymers 0.000 claims description 14
- 239000000463 material Substances 0.000 claims description 13
- 239000002184 metal Substances 0.000 claims description 4
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 3
- 239000011521 glass Substances 0.000 claims description 3
- 239000004033 plastic Substances 0.000 claims description 3
- 229920003023 plastic Polymers 0.000 claims description 3
- 239000011148 porous material Substances 0.000 claims description 3
- 239000000919 ceramic Substances 0.000 claims description 2
- 239000002241 glass-ceramic Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 9
- 238000007789 sealing Methods 0.000 abstract description 8
- 239000000701 coagulant Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- PNEYBMLMFCGWSK-UHFFFAOYSA-N Alumina Chemical group [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 101710145505 Fiber protein Proteins 0.000 description 1
- 206010018910 Haemolysis Diseases 0.000 description 1
- 238000012742 biochemical analysis Methods 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 229910010293 ceramic material Inorganic materials 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000003670 easy-to-clean Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 229920002492 poly(sulfone) Polymers 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000012106 screening analysis Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150015—Source of blood
- A61B5/15003—Source of blood for venous or arterial blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150755—Blood sample preparation for further analysis, e.g. by separating blood components or by mixing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/153—Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
- A61B5/154—Devices using pre-evacuated means
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The invention relates to a blood collection tube for instant serum separation, which consists of a tube body (1), a sealing plug (2), a separation membrane (3), a blood collection needle tube (4) and a serum discharge tube (5); the top end of the tube body (1) is sealed by a sealing plug (2); the separation membrane passes through the sealing plug (2) and enters the tube body; the blood sampling needle tube (4) is connected with the sealing plug (2); the serum discharge pipe (5) is tightly wrapped outside the separation membrane (3). The device structure is simple and easy, realizes serum quickly separating in step at the blood sampling in-process, obtains high-quality serum sample, increases the reliability of testing result.
Description
Technical field
The present invention relates to a kind of novel heparin tubes for the separation of instant serum.Designed heparin tube can be applied to blood
The whole blood to liquefy in testing extracts and realizes the instant extraction of serum, can significantly simplify the diagnostic process of blood testing.
Background technique
Examination of serum in modern medical service is needed by a series of processes such as vacuum blood collection, centrifuge separation, biochemical analysis.It is logical
Often, coagulant need to be added when blood sampling in vacuum blood collection tube, accelerates coagulation process, then blood constitutent is made by the effect of centrifugal force
Layering carries out biochemical project detection to obtain serum.And after adding coagulant, it will appear fiber protein yarn and block in blood
Block the situations such as Biochemical Analyzer blood taking needle, haemolysis, seriously affects the reliability of testing result.Meanwhile in centrifugal process due to
The special tectonic of haemocyte, so that the unbearable excessively high centrifugal force of cell membrane, causes centrifugal rotational speed to be normally controlled in lower
Level can not completely separate component in most cases, and certain influence is also resulted in testing result.
Membrane technology as a kind of novel isolation technics with its green, low-carbon, it is sustainable the features such as, must in medical industry
Promotion and application gradually are arrived.For the demand of blood separation, membrane structure is designed, the blood compatibility property of film is improved, adjusted
Membrane pore size is, it can be achieved that blood constitutent is precisely separated.Based on principles above, this patent devises a kind of novel heparin tube,
It is realized in blood collection procedure and the original position of serum is obtained, the efficiency and precision of blood testing are improved, for the blood of medicine
Urgent blood transfusion screening in quick chemical examination and first aid procedures has important clinical meaning.
Summary of the invention
It is an object of the invention to a kind of blood sampling of instant serum separation is provided to improve the deficiencies in the prior art
It manages, original position is synchronized in blood collection procedure and isolates serum, improves blood testing efficiency.This method is fast and convenient, is suitable for doctor
Treat diagnosis in serum rapidly extracting, can it is easy to clean and replacement, cost is relatively low, have good medical prospect.
The technical solution of the present invention is as follows: a kind of heparin tube of instant serum separation, it is characterised in that: by tube body 1, sealing-plug
2, seperation film 3, blood-collecting needle tube 4, serum discharge nozzle 5 form；Tube body 1 is apparatus main body, and top is sealed by sealing-plug 2；Separation
3 one end of film passes through sealing-plug 2 and enters in tube body, and the other end is outside tube body；Blood-collecting needle tube 4 is connected with sealing-plug 2 enters tube body
It is interior；5 tight of serum discharge nozzle is not in 3 outside one end of seperation film, not and sealing-plug 2.
It is preferred that 1 material of above-mentioned tubular body is glass, acrylic, glass ceramics, plastics or metal；Its top diameter is in 1-
10cm, length is in 5-20cm.
The fixedly separated film 3 of above-mentioned sealing-plug 2, and keep sealing.
It is preferred that above-mentioned separation membrane material is the blood compatibility materials such as ceramic membrane, metal film or organic film；Preferable separate passes
Sense film outer diameter is generally 1-4mm, internal diameter 0.1-0.9mm, length 5-20cm, and pore diameter range is 0.01-1 μm；Separation
The length range that film stretches out sealing-plug is 0.5-2cm.It is preferred that above-mentioned separation membrane structure is hollow tubular structure.
The seperation film stretches out sealing-plug 2, and the part for being present in tubular body is not in contact with tube body.
Seperation film is fixed in the middle part of sealing-plug and does not contact with tube body, and serum discharge nozzle tight stretches out close in seperation film
The part of blocking.Blood-collecting needle tube, which is located at plug rim and enters in tube body, not to be contacted with tube body and seperation film, and is protruded into tube body
Length be 0.5-1cm.
Blood enters tube body by blood-collecting needle tube, and enters in seperation film under motive force, and the serum isolated is by membrane tube
Body, which flows out and passes through serum discharge nozzle, is discharged collection.
The utility model has the advantages that
The present invention is to be designed based on membrane separation technique and prepared the blood-taking device with serum separation function.The device
Have the speciality of separator, the extraction of serum can be carried out to the blood direct in-situ of acquisition.Apparatus structure design is simple, energy
Serum is rapidly extracted, the blood testing efficiency of hospital is improved, provides high precision for the urgent Screening analysis of blood in first aid
The measuring means of degree.
Detailed description of the invention
Fig. 1 is a kind of heparin tube structural schematic diagram of instant serum separation: 1- tube body；2- sealing-plug；3- seperation film；4- is adopted
Blood needle tubing；5- serum discharge nozzle.
Specific embodiment
Embodiment 1
As shown in Figure 1, Novel blood taking tube of the invention is apparatus main body with tube body 1, top is sealed by sealing-plug 2；Point
It passes through sealing-plug 2 from 3 one end of film to enter in tube body, the other end is outside tube body；Blood-collecting needle tube 4 is connected into pipe with sealing-plug 2
In vivo；Serum discharge nozzle 5 is connected to 3 outside one end of seperation film.
The seperation film is fixed in the middle part of sealing-plug and does not contact with tube body, and serum discharge nozzle tight is outside seperation film
Surface, blood-collecting needle tube, which is located at plug rim and enters in tube body, not to be contacted with tube body and seperation film.
1 material of tube body is glass: top diameter 1cm, a height of 7cm.
2 diameter dimension of sealing-plug matches pipe diameter, is highly 1cm.
Seperation film 3 be hollow tubular structure, outer diameter 1.5mm, internal diameter 0.4mm, pipe range 6cm, aperture 200nm,
The height for stretching out sealing-plug 2 is 0.5cm.
It is 0.5cm that blood-collecting needle tube 4, which protrudes into length in tube body,.
The length of blood-collecting needle tube 4 and serum discharge nozzle 5 can practical adjustments as needed.
3 material of seperation film is alumina ceramic material.
The sealing-plug 2 can fix sensing membrane 3, and keep sealing.
3 structure of seperation film is hollow tubular structure.
The seperation film 3 stretches out sealing-plug 2, and the part for being present in tubular body is located at tube body contact.
The seperation film 3 is connect with 5 air-tightness of serum discharge nozzle.
Embodiment 2
Referring to attached drawing 1, the preferred size of blood separating mechanism of the invention is described in detail.
The top diameter of tube body 1 is 5cm, a height of 13cm.
The diameter dimension of sealing-plug 2 matches tube body size, is highly 1cm.
Seperation film 3 be hollow tubular structure, outer diameter 2.6mm, internal diameter 0.6mm, pipe range 12cm, aperture 500nm,
Stretching 2 height of sealing-plug is 1cm.
It is 0.8cm that blood-collecting needle tube 4, which protrudes into length in tube body,.
The length of blood-collecting needle tube 4 and serum discharge nozzle 5 can practical adjustments as needed.
1 material of tube body is acrylic.
The sealing-plug 2 can fix sensing membrane 3, and keep sealing.
3 material of seperation film is polysulfone material.
3 structure of seperation film is hollow tubular structure.
The seperation film 3 stretches out sealing-plug 2, and the part for being present in tube body is not contacted with tube body.
The seperation film 3 is connected with 5 air-tightness of serum discharge nozzle.
Embodiment 3
Referring to attached drawing 1, the preferred size of blood separating mechanism of the invention is described in detail.
The top diameter of tube body 1 is 7cm, a height of 18cm.
The diameter dimension of sealing-plug 2 matches tube body size, is highly 1cm.
Seperation film 3 is hollow tubular structure, and outer diameter 3.5mm, internal diameter 0.9mm, pipe range 16cm, aperture is 1 μm, is stretched
2 height of sealing-plug is 2cm out.
It is 1cm that blood-collecting needle tube 4, which protrudes into length in tube body,.
The length of blood-collecting needle tube 4 and serum discharge nozzle 5 can practical adjustments as needed.
1 material of tube body is plastics.
The sealing-plug 2 can fix sensing membrane 3, and keep sealing.
3 material of seperation film is stainless steel material.
3 structure of seperation film is hollow tubular structure.
The seperation film 3 stretches out sealing-plug 2, and the part for being present in tube body is not contacted with tube body.
The seperation film 3 is connected with 5 air-tightness of serum discharge nozzle.
The serum that the present apparatus can quickly extract high-quality is detected for blood testing.When work, discharge in serum
End connection vacuum pump, opens vacuum pump, and haemocyte is rejected by, and the serum isolated flows out via film inner wall and gone out by serum
Expect that end discharge is collected.
Using whole blood as raw material, the separating property of Novel blood taking tube described in embodiment 1-3 is as follows:
Three embodiments described above are only the preferred embodiment of the present invention, before not departing from the technology of the present invention principle
It puts, being correspondingly improved and replacing also should be regarded as protection scope of the present invention.
Claims (8)
1. a kind of heparin tube of instant serum separation, it is characterised in that: by tube body (1), sealing-plug (2), seperation film (3), blood sampling
Needle tubing (4), serum discharge nozzle (5) composition；Tube body (1) is apparatus main body, and top is sealed by sealing-plug 2；Seperation film (3) one end
Enter in tube body across sealing-plug (2), the other end is outside tube body；Blood-collecting needle tube (4) is connected with sealing-plug (2) enters tube body
It is interior；Serum discharge nozzle (5) tight is not in the external one end of seperation film (3), not and sealing-plug (2).
2. heparin tube according to claim 1, it is characterised in that: tube body (1) material is glass, acrylic, glass
Ceramics, plastics or metal.
3. heparin tube according to claim 1, it is characterised in that: the separation membrane material is ceramic membrane, metal film or has
Machine film.
4. heparin tube according to claim 1, it is characterised in that: the separation membrane structure is hollow tubular structure.
5. heparin tube according to claim 1, it is characterised in that: the top diameter of tube body (1) is 1-10cm, and length is in 5-
20cm。
6. heparin tube according to claim 1, it is characterised in that: seperation film (3) outer diameter is 1-4mm, internal diameter 0.1-
0.9mm, length 5-20cm, pore diameter range are 0.01-1 μm.
7. heparin tube according to claim 1, it is characterised in that: the length that seperation film (3) stretches out sealing-plug (2) is 0.5-
2cm。
8. heparin tube according to claim 1, it is characterised in that: the length that blood-collecting needle tube (4) protrudes into tube body (1) is
0.5-1cm。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810671755.2A CN109157228A (en) | 2018-06-26 | 2018-06-26 | Blood collection tube for instant serum separation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810671755.2A CN109157228A (en) | 2018-06-26 | 2018-06-26 | Blood collection tube for instant serum separation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109157228A true CN109157228A (en) | 2019-01-08 |
Family
ID=64897257
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810671755.2A Pending CN109157228A (en) | 2018-06-26 | 2018-06-26 | Blood collection tube for instant serum separation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109157228A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111610235A (en) * | 2020-06-03 | 2020-09-01 | 南京工业大学 | Clinical blood on-line analysis and detection device and method |
| CN114778639A (en) * | 2022-05-13 | 2022-07-22 | 南京工业大学 | Physiological index on-line monitoring instrument based on separation sensing membrane |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5238655A (en) * | 1990-07-09 | 1993-08-24 | Bradley V. Brown | Apparatus for collecting blood sample |
| US20010044615A1 (en) * | 2000-05-16 | 2001-11-22 | Fuji Photo Film Co., Ltd. | Plasma collecting device |
| CN1714292A (en) * | 2002-11-19 | 2005-12-28 | 积水化学工业株式会社 | Plasma or serum separation membrane and filter apparatus including the plasma or serum separation membrane |
| CN102764133A (en) * | 2012-08-10 | 2012-11-07 | 上海科华检验医学产品有限公司 | Vacuum blood collection tube and method thereof capable of directly separating blood plasma |
| CN202875351U (en) * | 2012-08-10 | 2013-04-17 | 上海科华检验医学产品有限公司 | Vacuum blood sampling tube capable of directly separating serum |
| CN203852358U (en) * | 2014-04-23 | 2014-10-01 | 湖南千山制药机械股份有限公司 | Vacuum blood collection tube for separating serum |
| CN204542153U (en) * | 2015-04-19 | 2015-08-12 | 黄燎源 | A kind of medical blood taking pipe |
-
2018
- 2018-06-26 CN CN201810671755.2A patent/CN109157228A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5238655A (en) * | 1990-07-09 | 1993-08-24 | Bradley V. Brown | Apparatus for collecting blood sample |
| US20010044615A1 (en) * | 2000-05-16 | 2001-11-22 | Fuji Photo Film Co., Ltd. | Plasma collecting device |
| CN1714292A (en) * | 2002-11-19 | 2005-12-28 | 积水化学工业株式会社 | Plasma or serum separation membrane and filter apparatus including the plasma or serum separation membrane |
| CN102764133A (en) * | 2012-08-10 | 2012-11-07 | 上海科华检验医学产品有限公司 | Vacuum blood collection tube and method thereof capable of directly separating blood plasma |
| CN202875351U (en) * | 2012-08-10 | 2013-04-17 | 上海科华检验医学产品有限公司 | Vacuum blood sampling tube capable of directly separating serum |
| CN203852358U (en) * | 2014-04-23 | 2014-10-01 | 湖南千山制药机械股份有限公司 | Vacuum blood collection tube for separating serum |
| CN204542153U (en) * | 2015-04-19 | 2015-08-12 | 黄燎源 | A kind of medical blood taking pipe |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111610235A (en) * | 2020-06-03 | 2020-09-01 | 南京工业大学 | Clinical blood on-line analysis and detection device and method |
| CN114778639A (en) * | 2022-05-13 | 2022-07-22 | 南京工业大学 | Physiological index on-line monitoring instrument based on separation sensing membrane |
| CN114778639B (en) * | 2022-05-13 | 2024-04-16 | 南京工业大学 | Physiological index on-line monitoring instrument based on separation sensing film |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190108 |