CN109125360A - A kind of preparation method of Shilintong Granule thick paste - Google Patents
A kind of preparation method of Shilintong Granule thick paste Download PDFInfo
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- 238000002360 preparation method Methods 0.000 title claims abstract description 39
- 239000008187 granular material Substances 0.000 title claims abstract description 30
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 95
- 235000019441 ethanol Nutrition 0.000 claims abstract description 66
- 244000227573 Desmodium styracifolium Species 0.000 claims abstract description 37
- 239000012141 concentrate Substances 0.000 claims abstract description 34
- 239000000463 material Substances 0.000 claims abstract description 33
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 31
- 238000001556 precipitation Methods 0.000 claims abstract description 28
- 239000000706 filtrate Substances 0.000 claims abstract description 23
- 239000006071 cream Substances 0.000 claims abstract description 19
- 238000000605 extraction Methods 0.000 claims abstract description 19
- 238000001914 filtration Methods 0.000 claims abstract description 16
- 239000007788 liquid Substances 0.000 claims abstract description 11
- 238000004064 recycling Methods 0.000 claims abstract description 9
- 239000006228 supernatant Substances 0.000 claims abstract description 9
- 238000004140 cleaning Methods 0.000 claims abstract description 8
- 238000003756 stirring Methods 0.000 claims abstract description 4
- 238000005303 weighing Methods 0.000 claims abstract description 4
- 238000000034 method Methods 0.000 claims description 14
- 238000005406 washing Methods 0.000 claims description 13
- 238000007906 compression Methods 0.000 claims description 7
- 230000006835 compression Effects 0.000 claims description 7
- 238000012423 maintenance Methods 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 abstract description 11
- 239000000047 product Substances 0.000 abstract description 4
- 241000208340 Araliaceae Species 0.000 description 5
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 5
- 235000003140 Panax quinquefolius Nutrition 0.000 description 5
- 238000005520 cutting process Methods 0.000 description 5
- 235000008434 ginseng Nutrition 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 2
- 208000004880 Polyuria Diseases 0.000 description 1
- 206010037596 Pyelonephritis Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 201000001352 cholecystitis Diseases 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/04—Drugs for disorders of the urinary system for urolithiasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
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Abstract
The invention discloses a kind of preparation methods of Shilintong Granule thick paste, comprising: material preparation step: weighing Desmodium styracifolium, is cleaned, and the section of 2-3cm long is cut into after cleaning, obtains Desmodium styracifolium segment, spare；Extraction step: Desmodium styracifolium segment is taken, adds 9-11 times of water for the first time, boils for the first time, is filtered；Second plus 9-11 times of water, boil for the second time, filter, merging filtrate；Concentration step: filtrate is concentrated, and obtains concentrate；Alcohol precipitation and receipts cream step: taking concentrate that ethyl alcohol is added to stir evenly, after standing, by the supernatant liquid filtering after alcohol precipitation, then recycle ethyl alcohol, and the medicinal extract after recycling ethyl alcohol is concentrated again, obtains thick paste.The loss of the medicinal material effective component of the preparation method is small, the high income of thick paste, can be improved production efficiency and reduces production cost, guarantees product quality.
Description
Technical field
The present invention relates to a kind of preparation methods of Shilintong Granule thick paste.
Background technique
Granule (Granules) is manufactured granular formulations by drug and suitable auxiliary material cooperation, be generally can be divided into
Soluble granule, suspension granule and effervescency granule.It is mainly characterized by directly swallowing, and can also pour water
In drink into, application and carry more convenient, dissolution and infiltration rate are very fast.The ingredient of Shilintong Granule is Desmodium styracifolium.Mainly
Effect: stone is arranged in clear warm, diuresis.For lithangiuria, pyelonephritis, cholecystitis.
In the prior art, in Shilintong Granule production process, using water boiling method extract Desmodium styracifolium in it is effective at
Point, the loss of the effective component of medicinal material is big.
Summary of the invention
For overcome the deficiencies in the prior art, an object of the present invention is to provide a kind of preparation of Shilintong Granule thick paste
The loss of method, the medicinal material effective component of the preparation method is small, and the high income of thick paste can be improved production efficiency and reduction
Production cost guarantees product quality.
A kind of preparation method of Shilintong Granule thick paste characterized by comprising
Material preparation step: weighing Desmodium styracifolium, is cleaned, and the section of 2-3cm long is cut into after cleaning, obtains Desmodium styracifolium piece
Section, it is spare；
Extraction step: Desmodium styracifolium segment is taken, adds 9-11 times of water for the first time, boils for the first time, is filtered；Second plus 9-11
Times water, boils for the second time, filters, merging filtrate；
Concentration step: filtrate is concentrated, and obtains concentrate；
Alcohol precipitation and receipts cream step: it takes concentrate that ethyl alcohol is added to stir evenly, after standing, then the supernatant liquid filtering after alcohol precipitation returns
Ethyl alcohol is received, the medicinal extract after recycling ethyl alcohol is concentrated again, obtains thick paste.
Further, in material preparation step, Desmodium styracifolium is weighed, is cleaned by medicine-washing machine, is cut into 2.5cm's long after cleaning
Section, obtains Desmodium styracifolium segment, spare.
Further, extraction step takes Desmodium styracifolium segment, adds 10 times of water for the first time, boil for the first time, filters；Second
Secondary plus 10 times of water, boil for the second time, filter, merging filtrate.
Further, in extraction step, boil that detailed process is as follows for the first time: maintenance 1 is boiled in 95-100 DEG C of temperature of control
Hour.
Further, in extraction step, boil that detailed process is as follows for the second time: maintenance 1 is boiled in 95-100 DEG C of temperature of control
Hour.
Further, in concentration step, filtrate is once concentrated and secondary concentration, obtains concentrate；Wherein, once
The parameter of concentration is as follows: concentration pressure is less than 0.5MPa, a temperature is 70-95 DEG C, a vacuum degree be (- 0.03)-(-
0.08)MPa；The parameter of secondary concentration is as follows: concentration pressure is less than 0.5MPa, and secondary temperature is 60-85 DEG C, secondary vacuum degree is
(-0.04)-(-0.09)MPa。
Further, in concentration step, the relative density of concentrate is 1.20-1.22, and temperature is 60 DEG C.
Further, in alcohol precipitation and receipts cream step, take concentrate that the ethyl alcohol that concentration is 85% or more is added, so that concentrate
In alcohol content up to 63%.
Further, in alcohol precipitation and receipts cream step, time of repose is 24 hours, and steam pressure is 0.4MPa or less, compresses
Temperature is 50-80 DEG C, vacuum degree is (- 0.05)-(- 0.09) MPa.
Further, in alcohol precipitation and receipts cream step, the relative density of thick paste is 1.20-1.25, and temperature is 60 DEG C.
The beneficial effects of the present invention are:
Preparation method of the invention is cut into the section of 2-3cm long, optimizes simultaneously in material preparation step after cleaning Desmodium styracifolium
Extraction step, concentration step, alcohol precipitation and the parameter for receiving cream step, so that the loss of the effective component of medicinal material is small, the receipts of thick paste
Rate is high, can be improved production efficiency and reduces production cost, guarantees product quality.
Specific embodiment
In the following, being described further in conjunction with specific embodiment to the present invention, it should be noted that is do not collided
Under the premise of, new embodiment can be formed between various embodiments described below or between each technical characteristic in any combination.
A kind of preparation method of Shilintong Granule thick paste, comprising:
Material preparation step: weighing Desmodium styracifolium, is cleaned, and the section of 2-3cm long is cut into after cleaning, obtains Desmodium styracifolium piece
Section, it is spare；
Extraction step: Desmodium styracifolium segment is taken, adds 9-11 times of water for the first time, boils for the first time, is filtered；Second plus 9-11
Times water, boils for the second time, filters, merging filtrate；
Concentration step: filtrate is concentrated, and obtains concentrate；
Alcohol precipitation and receipts cream step: it takes concentrate that ethyl alcohol is added to stir evenly, after standing, then the supernatant liquid filtering after alcohol precipitation returns
Ethyl alcohol is received, the medicinal extract after recycling ethyl alcohol is concentrated again, obtains thick paste.
As preferred embodiment, in material preparation step, Desmodium styracifolium is weighed, is cleaned by medicine-washing machine, is cut after cleaning
At the section of 2.5cm long, Desmodium styracifolium segment is obtained, it is spare.
Further, extraction step takes Desmodium styracifolium segment, adds 10 times of water for the first time, boil for the first time, filters；Second
Secondary plus 10 times of water, boil for the second time, filter, merging filtrate.
As preferred embodiment, in extraction step, boil that detailed process is as follows: control temperature 95-100 for the first time
DEG C, boil maintenance 1 hour.
As preferred embodiment, in extraction step, boil that detailed process is as follows: control temperature 95-100 for the second time
DEG C, boil maintenance 1 hour.
As preferred embodiment, in concentration step, filtrate is once concentrated and secondary concentration, is concentrated
Liquid；Wherein, the parameter being once concentrated is as follows: concentration pressure is less than 0.5MPa, and a temperature is 70-95 DEG C, a vacuum degree is
(-0.03)-(-0.08)MPa；The parameter of secondary concentration is as follows: concentration pressure is less than 0.5MPa, and secondary temperature is 60-85 DEG C, two
Secondary vacuum degree is (- 0.04)-(- 0.09) MPa.
As preferred embodiment, in concentration step, the relative density of concentrate is 1.20-1.22, and temperature is 60 DEG C.
As preferred embodiment, in alcohol precipitation and receipts cream step, take concentrate that the ethyl alcohol that concentration is 85% or more is added,
So that alcohol content in concentrate is up to 63%.
As preferred embodiment, in alcohol precipitation and receipts cream step, time of repose is 24 hours, steam pressure 0.4MPa
Below, compression temperature is 50-80 DEG C, vacuum degree is (- 0.05)-(- 0.09) MPa.
As preferred embodiment, in alcohol precipitation and receipts cream step, the relative density of thick paste is 1.20-1.25, and temperature is
60℃。
The following are specific embodiments of the present invention, and used raw material, equipment etc. remove special limit in the following embodiments
It can be obtained by buying pattern outside fixed.
Embodiment 1:
A kind of preparation method of Shilintong Granule thick paste, comprising:
Material preparation step: taking Desmodium styracifolium medicinal material 2000g, and medicinal material is put into wash pond, then plus to drink water submerged medicinal material laggard
Row washing, is fitted into cutting in circulating frame after washing, after being cut into the section of 2.5cm, obtains Desmodium styracifolium segment, spare；
Extraction step: taking Desmodium styracifolium segment 1500g, and for the first time plus water 15L, 98 DEG C of temperature of control decoct 1 hour, mistake
Filter；Second plus water 15L, 98 DEG C of temperature are controlled, is decocted 1 hour, filtering, merging filtrate；
Concentration step: filtrate is once concentrated and secondary concentration, obtains 3L concentrate；Wherein, the ginseng being once concentrated
Number is as follows: concentration pressure is less than 0.5MPa, and a temperature is 85 DEG C, a vacuum degree is -0.06MPa；The parameter of secondary concentration
As follows: concentration pressure is less than 0.5MPa, and secondary temperature is 70 DEG C, secondary vacuum degree is -0.07MPa；
Alcohol precipitation and receipts cream step: take concentrate that the ethyl alcohol that concentration is 85% or more is added, so that the alcohol content in concentrate
Up to 63%, time of repose is 24 hours, by the supernatant liquid filtering after alcohol precipitation, then recycles ethyl alcohol, by the medicinal extract after recycling ethyl alcohol
It is concentrated again, obtains 300g thick paste；In concentration process, steam pressure is 0.4MPa or less, compression temperature is 65 DEG C, vacuum degree be-
0.07MPa, the relative density of thick paste are 1.22, and temperature is 60 DEG C.
Embodiment 2:
A kind of preparation method of Shilintong Granule thick paste, comprising:
Material preparation step: taking Desmodium styracifolium medicinal material 2000g, and medicinal material is put into wash pond, then plus to drink water submerged medicinal material laggard
Row washing, is fitted into cutting in circulating frame after washing, after being cut into the section of 2cm, obtains Desmodium styracifolium segment, spare；
Extraction step: taking Desmodium styracifolium segment 1500g, and for the first time plus water 15L, 95 DEG C of temperature of control decoct 1 hour, mistake
Filter；Second plus water 15L, 95 DEG C of temperature are controlled, is decocted 1 hour, filtering, merging filtrate；
Concentration step: filtrate is once concentrated and secondary concentration, obtains 3L concentrate；Wherein, the ginseng being once concentrated
Number is as follows: concentration pressure is less than 0.5MPa, and a temperature is 95 DEG C, a vacuum degree is -0.03MPa；The parameter of secondary concentration
As follows: concentration pressure is less than 0.5MPa, and secondary temperature is 85 DEG C, secondary vacuum degree is -0.04MPa；
Alcohol precipitation and receipts cream step: take concentrate that the ethyl alcohol that concentration is 85% or more is added, so that the alcohol content in concentrate
Up to 63%, time of repose is 24 hours, by the supernatant liquid filtering after alcohol precipitation, then recycles ethyl alcohol, by the medicinal extract after recycling ethyl alcohol
It is concentrated again, obtains 310g thick paste；In concentration process, steam pressure is 0.4MPa or less, compression temperature is 80 DEG C, vacuum degree be-
0.05MPa, the relative density of thick paste are 1.22, and temperature is 60 DEG C.
Embodiment 3:
A kind of preparation method of Shilintong Granule thick paste, comprising:
Material preparation step: taking Desmodium styracifolium medicinal material 155kg, and medicinal material is put into wash pond, then plus to drink water submerged medicinal material laggard
Row washing, is fitted into cutting in circulating frame after washing, after being cut into the section of 3cm, obtains Desmodium styracifolium segment, spare；
Extraction step: taking Desmodium styracifolium segment 150kg, and for the first time plus water 1500L, 100 DEG C of temperature of control decoct 1 hour,
Filtering；Second plus water 1500L, 100 DEG C of temperature are controlled, is decocted 1 hour, filtering, merging filtrate；
Concentration step: filtrate is once concentrated and secondary concentration, obtains 104L concentrate；Wherein, it is once concentrated
Parameter is as follows: concentration pressure is less than 0.5MPa, and a temperature is 85 DEG C, a vacuum degree is -0.05MPa；The ginseng of secondary concentration
Number is as follows: concentration pressure is less than 0.5MPa, and secondary temperature is 75 DEG C, secondary vacuum degree is -0.06MPa；
Alcohol precipitation and receipts cream step: take concentrate that the ethyl alcohol that concentration is 85% or more is added, so that the alcohol content in concentrate
Up to 63%, time of repose is 24 hours, by the supernatant liquid filtering after alcohol precipitation, then recycles ethyl alcohol, by the medicinal extract after recycling ethyl alcohol
It is concentrated again, obtains 23.5kg thick paste；In concentration process, steam pressure is 0.4MPa or less, compression temperature is 50 DEG C, vacuum degree
For -0.09MPa, the relative density of thick paste is 1.21, and temperature is 60 DEG C.
Embodiment 4:
A kind of preparation method of Shilintong Granule thick paste, comprising:
Material preparation step: taking Desmodium styracifolium medicinal material 155kg, and medicinal material is put into wash pond, then plus to drink water submerged medicinal material laggard
Row washing, is fitted into cutting in circulating frame after washing, after being cut into the section of 2cm, obtains Desmodium styracifolium segment, spare；
Extraction step: taking Desmodium styracifolium segment 150kg, and for the first time plus water 15L, 97 DEG C of temperature of control decoct 1 hour, mistake
Filter；Second plus water 15L, 97 DEG C of temperature are controlled, is decocted 1 hour, filtering, merging filtrate；
Concentration step: filtrate is once concentrated and secondary concentration, obtains 103L concentrate；Wherein, it is once concentrated
Parameter is as follows: concentration pressure is less than 0.5MPa, and a temperature is 70 DEG C, a vacuum degree is -0.08MPa；The ginseng of secondary concentration
Number is as follows: concentration pressure is less than 0.5MPa, and secondary temperature is 85 DEG C, secondary vacuum degree is -0.09MPa；
Alcohol precipitation and receipts cream step: take concentrate that the ethyl alcohol that concentration is 85% or more is added, so that the alcohol content in concentrate
Up to 63%, time of repose is 24 hours, by the supernatant liquid filtering after alcohol precipitation, then recycles ethyl alcohol, by the medicinal extract after recycling ethyl alcohol
It is concentrated again, obtains 24kg thick paste；In concentration process, steam pressure is 0.4MPa or less, compression temperature is 80 DEG C, vacuum degree be-
0.05MPa, the relative density of thick paste are 1.21, and temperature is 60 DEG C.
Comparative example 1:
A kind of preparation method of Shilintong Granule thick paste, comprising:
Material preparation step: taking Desmodium styracifolium medicinal material 2000g, and medicinal material is put into wash pond, then plus to drink water submerged medicinal material laggard
Row washing, is fitted into cutting in circulating frame after washing, after being cut into the section of 5cm, obtains Desmodium styracifolium segment, spare；
Extraction step: taking Desmodium styracifolium segment 1500g, and for the first time plus water 15L, 98 DEG C of temperature of control decoct 1 hour, mistake
Filter；Second plus water 15L, 98 DEG C of temperature are controlled, is decocted 1 hour, filtering, merging filtrate；
Concentration step: filtrate is once concentrated and secondary concentration, obtains 5L concentrate；Wherein, the ginseng being once concentrated
Number is as follows: concentration pressure is less than 0.5MPa, and a temperature is 85 DEG C, a vacuum degree is -0.06MPa；The parameter of secondary concentration
As follows: concentration pressure is less than 0.5MPa, and secondary temperature is 70 DEG C, secondary vacuum degree is -0.07MPa；
Alcohol precipitation and receipts cream step: take concentrate that the ethyl alcohol that concentration is 85% or more is added, so that the alcohol content in concentrate
Up to 63%, time of repose is 24 hours, by the supernatant liquid filtering after alcohol precipitation, then recycles ethyl alcohol, by the medicinal extract after recycling ethyl alcohol
It is concentrated again, obtains 100g thick paste；In concentration process, steam pressure is 0.4MPa or less, compression temperature is 65 DEG C, vacuum degree be-
0.07MPa, the relative density of thick paste are 1.22, and temperature is 60 DEG C.
Thick paste amount such as the following table 1 is obtained according to embodiment 1-4 and 1 preparation method of comparative example:
Table 1
| Project | Thick paste amount | Thick paste standard volume | As a result |
| Comparative example 1 | 100g | 200g | It is unqualified |
| Embodiment 1 | 300g | 200g | It is qualified |
| Embodiment 2 | 310g | 200g | It is qualified |
| Embodiment 3 | 23.5kg | 22kg ± 5% | It is qualified |
| Embodiment 4 | 24kg | 22kg ± 5% | It is qualified |
As seen from the data in Table 1, it is extracted in production in Shilintong Granule, the thick paste amount of embodiment 1-4 is more, high income, meets
Production requirement can be improved production efficiency and reduce production cost, guarantees product quality.Wherein, with the effect of embodiment 2
Most preferably.
The above embodiment is only the preferred embodiment of the present invention, and the scope of protection of the present invention is not limited thereto,
The variation and replacement for any unsubstantiality that those skilled in the art is done on the basis of the present invention belong to institute of the present invention
Claimed range.
Claims (10)
1. a kind of preparation method of Shilintong Granule thick paste characterized by comprising
Material preparation step: weighing Desmodium styracifolium, is cleaned, and the section of 2-3cm long is cut into after cleaning, obtains Desmodium styracifolium segment, standby
With；
Extraction step: Desmodium styracifolium segment is taken, adds 9-11 times of water for the first time, boils for the first time, is filtered；Second plus 9-11 times
Water boils for the second time, filtering, merging filtrate；
Concentration step: filtrate is concentrated, and obtains concentrate；
Alcohol precipitation and receipts cream step: it takes concentrate that ethyl alcohol is added to stir evenly, after standing, by the supernatant liquid filtering after alcohol precipitation, then recycles second
Medicinal extract after recycling ethyl alcohol is concentrated again, obtains thick paste by alcohol.
2. the preparation method of Shilintong Granule thick paste as described in claim 1, which is characterized in that in material preparation step, weigh wide
Herba lysimachiae is cleaned by medicine-washing machine, and the section of 2.5cm long is cut into after cleaning, obtains Desmodium styracifolium segment, spare.
3. the preparation method of Shilintong Granule thick paste as described in claim 1, which is characterized in that extraction step takes wide money
Blade section adds 10 times of water for the first time, boils for the first time, filters；Second plus 10 times of water, boil for the second time, filter, and merge filter
Liquid.
4. the preparation method of Shilintong Granule thick paste as described in claim 1, which is characterized in that in extraction step, for the first time
Boil that detailed process is as follows: maintenance 1 hour is boiled in 95-100 DEG C of temperature of control.
5. the preparation method of Shilintong Granule thick paste as described in claim 1, which is characterized in that in extraction step, second
Boil that detailed process is as follows: maintenance 1 hour is boiled in 95-100 DEG C of temperature of control.
6. the preparation method of Shilintong Granule thick paste as described in claim 1, which is characterized in that in concentration step, by filtrate
It is once concentrated and secondary concentration, obtains concentrate；Wherein, the parameter being once concentrated is as follows: concentration pressure is less than 0.5MPa,
Temperature is 70-95 DEG C, a vacuum degree is (- 0.03)-(- 0.08) MPa；The parameter of secondary concentration is as follows: concentration pressure
Less than 0.5MPa, secondary temperature is 60-85 DEG C, secondary vacuum degree is (- 0.04)-(- 0.09) MPa.
7. the preparation method of Shilintong Granule thick paste as described in claim 1, which is characterized in that in concentration step, concentrate
Relative density be 1.20-1.22, temperature be 60 DEG C.
8. the preparation method of Shilintong Granule thick paste as described in claim 1, which is characterized in that in alcohol precipitation and receipts cream step,
Take concentrate that the ethyl alcohol that concentration is 85% or more is added, so that alcohol content in concentrate is up to 63%.
9. the preparation method of Shilintong Granule thick paste as described in claim 1, which is characterized in that in alcohol precipitation and receipts cream step,
Time of repose be 24 hours, steam pressure is 0.4MPa or less, compression temperature is 50-80 DEG C, vacuum degree be (- 0.05)-(-
0.09)MPa。
10. the preparation method of Shilintong Granule thick paste as described in claim 1, which is characterized in that in alcohol precipitation and receipts cream step,
The relative density of thick paste is 1.20-1.25, and temperature is 60 DEG C.
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| CN101249135A (en) * | 2008-03-28 | 2008-08-27 | 湖南长沙宝鉴生物工程有限公司 | Compound urolithic stranguria unlock capsules and preparation technique thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101249135A (en) * | 2008-03-28 | 2008-08-27 | 湖南长沙宝鉴生物工程有限公司 | Compound urolithic stranguria unlock capsules and preparation technique thereof |
Non-Patent Citations (2)
| Title |
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| 中华人民共和国卫生部药典委员会: "《中华人民共和国药典1990版一部》", 31 October 1990, 人民卫生出版社 * |
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Application publication date: 20190104 |