CN109091728A - A kind of micro liquid syringe and the method that parenchymal tissue is injected - Google Patents
A kind of micro liquid syringe and the method that parenchymal tissue is injected Download PDFInfo
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- CN109091728A CN109091728A CN201710646860.6A CN201710646860A CN109091728A CN 109091728 A CN109091728 A CN 109091728A CN 201710646860 A CN201710646860 A CN 201710646860A CN 109091728 A CN109091728 A CN 109091728A
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- 239000007788 liquid Substances 0.000 title claims abstract description 34
- 238000000034 method Methods 0.000 title claims abstract description 12
- 238000002347 injection Methods 0.000 claims abstract description 70
- 239000007924 injection Substances 0.000 claims abstract description 70
- 239000011521 glass Substances 0.000 claims description 10
- 239000002184 metal Substances 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 2
- 210000004204 blood vessel Anatomy 0.000 abstract description 26
- 210000003169 central nervous system Anatomy 0.000 abstract description 5
- 239000000835 fiber Substances 0.000 abstract description 5
- 230000002889 sympathetic effect Effects 0.000 abstract description 5
- 230000005587 bubbling Effects 0.000 abstract description 4
- 210000005037 parasympathetic nerve Anatomy 0.000 abstract description 4
- 230000000149 penetrating effect Effects 0.000 abstract description 3
- 241000700605 Viruses Species 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 238000002372 labelling Methods 0.000 description 4
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 description 2
- 206010020772 Hypertension Diseases 0.000 description 2
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 2
- 229920005372 Plexiglas® Polymers 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 210000000981 epithelium Anatomy 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 210000004126 nerve fiber Anatomy 0.000 description 2
- 230000001537 neural effect Effects 0.000 description 2
- 229960002748 norepinephrine Drugs 0.000 description 2
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 210000000329 smooth muscle myocyte Anatomy 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- 238000010146 3D printing Methods 0.000 description 1
- 241000197194 Bulla Species 0.000 description 1
- 208000001953 Hypotension Diseases 0.000 description 1
- 206010047139 Vasoconstriction Diseases 0.000 description 1
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 1
- 229960004373 acetylcholine Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 208000002352 blister Diseases 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 230000036543 hypotension Effects 0.000 description 1
- 238000000520 microinjection Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
- 210000001002 parasympathetic nervous system Anatomy 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 210000002820 sympathetic nervous system Anatomy 0.000 description 1
- 230000025033 vasoconstriction Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/19—Syringes having more than one chamber, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3129—Syringe barrels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3286—Needle tip design, e.g. for improved penetration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M2005/3201—Coaxially assembled needle cannulas placed on top of another, e.g. needles having different diameters
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- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
本发明涉及医疗器械技术领域，尤其涉及一种微量液体注射器及对薄壁组织进行注射的方法，其包括负压针和负压针筒，其中，所述负压针筒包括内筒和外筒，所述内筒的内壁与注射针筒紧密贴合，所述内筒的外壁与所述外筒的内壁紧密贴合，所述内筒在外力作用下能够相对于所述外筒和所述注射针筒移动；所述负压针连接于所述外筒的一端，且套设在注射针的外部，所述负压针与所述注射针之间存在间隙。本发明利用负压使血管壁等薄壁组织形成鼓泡，能够很好的控制注射针穿透血管壁等薄壁组织的深度，保证将微量液体注射入血管壁等薄壁组织中，为探索中枢神经系统是如何控制血管上分布的交感或副交感神经纤维的技术问题做出了突出的贡献。
The present invention relates to the technical field of medical devices, in particular to a micro-liquid injector and a method for injecting parenchyma, which includes a negative pressure needle and a negative pressure syringe, wherein the negative pressure syringe includes an inner cylinder and an outer cylinder , the inner wall of the inner cylinder is closely attached to the injection syringe, the outer wall of the inner cylinder is closely attached to the inner wall of the outer cylinder, and the inner cylinder can be relatively The injection needle barrel moves; the negative pressure needle is connected to one end of the outer cylinder and sleeved on the outside of the injection needle, and there is a gap between the negative pressure needle and the injection needle. The invention utilizes negative pressure to form bubbling in parenchyma such as blood vessel wall, can well control the depth of injection needle penetrating through parenchyma such as blood vessel wall, and ensures that a small amount of liquid is injected into parenchyma such as blood vessel wall. For outstanding contributions to the technical question of how the central nervous system controls the distribution of sympathetic or parasympathetic nerve fibers on blood vessels.
Description
技术领域technical field
本发明涉及医疗器械技术领域，尤其涉及一种用于血管等薄壁组织的微量液体注射器及对薄壁组织进行注射的方法。The invention relates to the technical field of medical devices, in particular to a microfluid injector for parenchyma such as blood vessels and a method for injecting parenchyma.
背景技术Background technique
血压是由血液在血管内流动时作用于血管壁的压力，是推动血液在血管内流动的动力。这一动力的改变，过低或者过高，会出现低血压或高血压。血管上皮分布着交感或者副交感神经纤维，这些纤维受控于中枢神经元，中枢神经兴奋或者抑制，会影响这些神经纤维释放单胺类神经递质、乙酰胆碱或者去甲肾上腺素，其中，去甲肾上腺素作用于血管上皮平滑肌细胞，平滑肌细胞收缩，导致血管收缩，血压升高。然而，中枢神经系统是如何控制交感和副交感神经系统的未可知，具体核团、神经环路、特异细胞均不知道。因此从血管做逆向标记寻找神经纤维发出的核团，甚至追踪核团之间的神经环路是非常重要的。Blood pressure is the pressure that the blood acts on the wall of the blood vessel when it flows in the blood vessel, and it is the driving force that pushes the blood to flow in the blood vessel. If this dynamic change is too low or too high, hypotension or high blood pressure will occur. The vascular epithelium is distributed with sympathetic or parasympathetic nerve fibers. These fibers are controlled by central neurons, and the central nervous system is excited or inhibited, which will affect the release of monoamine neurotransmitters, acetylcholine or norepinephrine from these nerve fibers. Among them, norepinephrine The hormone acts on the smooth muscle cells of the vascular epithelium, and the smooth muscle cells contract, resulting in vasoconstriction and increased blood pressure. However, how the central nervous system controls the sympathetic and parasympathetic nervous systems is unknown, and the specific nuclei, neural circuits, and specific cells are not known. Therefore, it is very important to do reverse labeling from the blood vessels to find the nuclei from the nerve fibers, and even trace the neural circuits between the nuclei.
血管逆向标记技术可以采用微量液体注射器直接向血管壁注射PRV逆向标记病毒，在七天左右取脑灌注，切片即可。现有的微量液体注射器的结构如图1所示，包括注射针筒1'、注射针2'、顶针3'和柱塞4'，其中，所述注射针2'连接于所述注射针筒1'一端，所述顶针3'插入所述注射针筒1'中，并可沿着所述注射针筒1'的长度方向移动，所述顶针3'位于所述注射针筒1'内部的一端设置有所述柱塞4'，所述柱塞4'可随所述顶针3'一起移动，并与所述注射针筒1'内壁气密性结合。Blood vessel reverse labeling technology can use a micro-liquid syringe to directly inject PRV reverse labeling virus into the blood vessel wall, and take brain perfusion in about seven days and slice it. The structure of the existing micro-liquid injector is shown in Figure 1, comprising an injection syringe 1', an injection needle 2', a thimble 3' and a plunger 4', wherein the injection needle 2' is connected to the injection syringe 1', the thimble 3' is inserted into the injection barrel 1' and can move along the length direction of the injection barrel 1', the thimble 3' is located inside the injection barrel 1' One end is provided with the plunger 4', the plunger 4' can move together with the thimble 3', and is airtightly combined with the inner wall of the injection syringe 1'.
传统的注射针2'采用金属制成，尖端的内径在200um左右，无法穿透坚韧的血管壁；故采用由毛细玻璃管拉制而成的注射针2'，尖端内径可以达到50um，虽然可以穿透血管壁，但是容易穿透血管壁将病毒注射进血液中，得不到血管逆向标记的结果。The traditional injection needle 2' is made of metal, and the inner diameter of the tip is about 200um, which cannot penetrate the tough blood vessel wall; therefore, the injection needle 2' made of capillary glass tube is used, and the inner diameter of the tip can reach 50um, although it can Penetrate the blood vessel wall, but it is easy to penetrate the blood vessel wall to inject the virus into the blood, and the result of reverse labeling of the blood vessel cannot be obtained.
因此，急需一种可以在保证不将病毒注射进血液中的情况下，将逆向标记病毒注射进血管壁的微量液体注射器。Therefore, there is an urgent need for a micro-fluid injector that can inject the retromarked virus into the blood vessel wall without injecting the virus into the blood.
发明内容Contents of the invention
本发明的目的在于提供一种微量液体注射器及对薄壁组织进行注射的方法，以解决现有技术存在的注射针容易穿透血管壁等薄壁组织的问题。The object of the present invention is to provide a micro-liquid syringe and a method for injecting parenchyma, so as to solve the problem in the prior art that injection needles easily penetrate parenchyma such as blood vessel walls.
为达此目的，本发明采用以下技术方案：For reaching this purpose, the present invention adopts following technical scheme:
一种微量液体注射器，包括：负压针筒和负压针，其中，所述负压针筒包括内筒和外筒，所述内筒的内壁与注射针筒紧密贴合，所述内筒的外壁与所述外筒的内壁紧密贴合，所述内筒在外力作用下能够相对于所述外筒和所述注射针筒移动；所述负压针连接于所述外筒的一端，且套设在注射针的外部，所述负压针与所述注射针之间存在间隙。A micro-liquid injector, comprising: a negative pressure syringe and a negative pressure needle, wherein the negative pressure syringe includes an inner cylinder and an outer cylinder, the inner wall of the inner cylinder is in close contact with the injection syringe, and the inner cylinder The outer wall of the outer cylinder is in close contact with the inner wall of the outer cylinder, and the inner cylinder can move relative to the outer cylinder and the injection syringe under the action of an external force; the negative pressure needle is connected to one end of the outer cylinder, And it is sheathed on the outside of the injection needle, and there is a gap between the negative pressure needle and the injection needle.
作为优选，所述内筒外露的一端形成凸缘把手。Preferably, the exposed end of the inner cylinder forms a flange handle.
作为优选，所述内筒与所述外筒之间以及所述内筒与所述注射针筒之间均设置有橡胶塞。Preferably, rubber stoppers are provided between the inner cylinder and the outer cylinder and between the inner cylinder and the injection syringe.
作为优选，所述负压针由有机玻璃制成。Preferably, the negative pressure needle is made of plexiglass.
作为优选，所述负压针的尖端的内径为0.3mm-1mm。Preferably, the inner diameter of the tip of the negative pressure needle is 0.3mm-1mm.
作为优选，所述负压针筒的材质为玻璃或金属。Preferably, the negative pressure syringe is made of glass or metal.
作为优选，所述注射针筒的筒壁上设置有刻度值。Preferably, scale values are provided on the cylinder wall of the injection syringe.
作为优选，所述注射针的尖端的内径为0.05mm-0.3mm。Preferably, the inner diameter of the tip of the injection needle is 0.05mm-0.3mm.
作为优选，所述注射针由毛细玻璃管拉制而成。Preferably, the injection needle is drawn from a capillary glass tube.
一种对薄壁组织进行注射的方法，该方法采用如上所述的微量液体注射器，包括如下步骤：A method for injecting parenchyma, the method using the above-mentioned micro-fluid injector, comprising the following steps:
将负压针的尖端贴合在薄壁组织上；Attach the tip of the negative pressure needle to the parenchyma;
向外抽拉内筒，使内筒相对于外筒和注射针筒移动，在负压针内形成负压，使所述薄壁组织形成鼓泡；Pull the inner cylinder outward, so that the inner cylinder moves relative to the outer cylinder and the injection syringe, and a negative pressure is formed in the negative pressure needle, so that the parenchyma forms a bubble;
推压注射针的顶针，将注射针筒内的微量液体注射进薄壁组织中。Push the thimble of the injection needle to inject a small amount of liquid in the injection syringe into the parenchyma.
本发明的有益效果：Beneficial effects of the present invention:
本发明提供的微量液体注射器及对薄壁组织进行注射的方法，利用负压使血管壁等薄壁组织形成鼓泡，能够很好的控制注射针穿透血管壁等薄壁组织的深度，保证将微量液体注射入血管壁等薄壁组织中，为探索中枢神经系统是如何控制血管上分布的交感或副交感神经纤维的技术问题做出了突出的贡献。The micro-liquid syringe and the method for injecting parenchyma provided by the present invention utilize negative pressure to form bubbling in the parenchyma such as the blood vessel wall, and can well control the depth of the injection needle penetrating the parenchyma such as the blood vessel wall, ensuring Injecting a small amount of liquid into parenchyma such as blood vessel walls has made outstanding contributions to exploring the technical issues of how the central nervous system controls the distribution of sympathetic or parasympathetic nerve fibers on blood vessels.
附图说明Description of drawings
图1是现有技术提供的一种微量液体注射器的结构示意图；Fig. 1 is a schematic structural view of a micro-liquid syringe provided in the prior art;
图2是本发明提供的微量液体注射器的结构示意图；Fig. 2 is a schematic structural view of a micro-liquid syringe provided by the present invention;
图3是本发明提供的微量液体注射器的使用时的示意图。Fig. 3 is a schematic diagram of the micro-liquid syringe provided by the present invention during use.
图中：In the picture:
1'-注射针筒；2'-注射针；3'-顶针；4'-柱塞；1'-injection barrel; 2'-injection needle; 3'-thimble; 4'-plunger;
1-注射针筒；2-注射针；3-顶针；4-柱塞；5-负压针筒；6-负压针；7-薄壁组织；1-injection syringe; 2-injection needle; 3-thimble; 4-plunger; 5-negative pressure syringe; 6-negative pressure needle; 7-parenchyma;
51-内筒；52-外筒；51-inner cylinder; 52-outer cylinder;
511-凸缘把手；511 - flange handle;
71-鼓泡。71 - Bubbling.
具体实施方式Detailed ways
下面结合附图和实施方式进一步说明本发明的技术方案。可以理解的是，此处所描述的具体实施例仅仅用于解释本发明，而非对本发明的限定。另外还需要说明的是，为了便于描述，附图中仅示出了与本发明相关的部分而非全部。The technical solutions of the present invention will be further described below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the present invention, but not to limit the present invention. In addition, it should be noted that, for the convenience of description, only the parts related to the present invention are shown in the drawings but not all of them.
如图2所示，本发明提供一种微量液体注射器，用于血管壁等薄壁组织的微量液体的注射，包括：注射针筒1、注射针2、顶针3、柱塞4、负压针筒5和负压针6，其中，注射针2连接于注射针筒1的一端，注射针2由毛细玻璃管拉制而成；顶针3插入注射针筒1内，并可沿着注射针筒1的长度方向移动；柱塞4设置于顶针3位于注射针筒1内部的一端，柱塞4可随顶针3一起移动，并与注射针筒1内壁气密性结合；负压针筒5包括内筒51和外筒52，内筒51的内壁与注射针筒1紧密贴合，内筒51的外壁与外筒52的内壁紧密贴合，内筒51在外力作用下能够相对于外筒52和注射针筒1移动；负压针6连接于外筒52的一端，且套设在注射针2的外部，负压针6与注射针2之间存在间隙。优选的，注射针2的尖端的中心正对负压针6的尖端的中心。As shown in Figure 2, the present invention provides a micro-liquid injector for injection of micro-liquid in parenchyma such as blood vessel walls, comprising: injection syringe 1, injection needle 2, thimble 3, plunger 4, negative pressure needle Barrel 5 and negative pressure needle 6, wherein the injection needle 2 is connected to one end of the injection syringe 1, and the injection needle 2 is drawn from a capillary glass tube; the thimble 3 is inserted into the injection syringe 1, and can be inserted along the injection syringe 1 moves in the length direction; the plunger 4 is set at the end of the thimble 3 inside the injection syringe 1, the plunger 4 can move together with the thimble 3, and is airtightly combined with the inner wall of the injection syringe 1; the negative pressure syringe 5 includes The inner cylinder 51 and the outer cylinder 52, the inner wall of the inner cylinder 51 is closely attached to the injection syringe 1, the outer wall of the inner cylinder 51 is closely attached to the inner wall of the outer cylinder 52, and the inner cylinder 51 can be pressed against the outer cylinder 52 under the action of external force. and the injection syringe 1 to move; the negative pressure needle 6 is connected to one end of the outer cylinder 52 and sleeved on the outside of the injection needle 2 , there is a gap between the negative pressure needle 6 and the injection needle 2 . Preferably, the center of the tip of the injection needle 2 is right to the center of the tip of the negative pressure needle 6 .
本发明提供的微量液体注射器在对血管壁等薄壁组织进行微量液体注射时，如图3所示，首先，使负压针6的尖端贴合在薄壁组织7上；然后，向外抽拉内筒51，使内筒51相对于外筒52和注射针筒1移动，在负压针6内形成负压，使薄壁组织7形成小丘状鼓泡71，此时，注射针2的尖端扎入鼓泡71处的薄壁组织7中；最后，推压顶针3，将注射针筒1内的微量液体注射进薄壁组织7中。When the micro-liquid injector provided by the present invention injects a micro-liquid into parenchyma such as blood vessel walls, as shown in Figure 3, at first, the tip of the negative pressure needle 6 is attached to the parenchyma 7; Pull the inner cylinder 51 to move the inner cylinder 51 relative to the outer cylinder 52 and the injection syringe 1, and form a negative pressure in the negative pressure needle 6, so that the parenchyma 7 forms a hillock-shaped bubble 71. At this time, the injection needle 2 The tip of the needle pierces into the parenchyma 7 at the bulla 71; finally, pushes the thimble 3 to inject a small amount of liquid in the injection syringe 1 into the parenchyma 7.
利用负压使薄壁组织7形成鼓泡71，能够很好的控制注射针2穿透薄壁组织7的深度，保证将微量液体注射入薄壁组织7中，为探索中枢神经系统是如何控制血管上分布的交感或副交感神经纤维的技术问题做出了突出的贡献。Using negative pressure to make the parenchyma 7 form bubbling 71, the depth of the injection needle 2 penetrating the parenchyma 7 can be well controlled, and a small amount of liquid can be injected into the parenchyma 7. In order to explore how the central nervous system controls Outstanding contributions were made to the technical issue of sympathetic or parasympathetic nerve fibers distributed over blood vessels.
进一步的，内筒51外露的一端形成凸缘把手511，用于被注射泵夹持，本发明提供的微量液体注射器的注射过程由注射泵操作完成，注射泵能保证全程匀速注射，控制精度高。Further, the exposed end of the inner cylinder 51 forms a flange handle 511, which is used to be clamped by the syringe pump. The injection process of the micro-liquid syringe provided by the present invention is completed by the syringe pump. The syringe pump can ensure uniform injection throughout the process, and the control accuracy is high. .
进一步的，为保证内筒51与外筒52之间结合的紧密性，在内筒51与外筒52之间设置有橡胶塞；另外，为保证内筒51与注射针筒1之间结合的紧密性，在内筒51与注射针筒1之间也设置有橡胶塞。Further, in order to ensure the tightness of the connection between the inner cylinder 51 and the outer cylinder 52, a rubber stopper is provided between the inner cylinder 51 and the outer cylinder 52; For tightness, a rubber stopper is also provided between the inner cylinder 51 and the injection syringe 1 .
负压针6由有机玻璃制成，尖端的内径为0.3mm-1mm，和血管外径近似；负压针筒5的材质为玻璃或金属。负压针6和负压针筒5可以手工拉制而成，也可以采用3D打印技术制作而成。The negative pressure needle 6 is made of plexiglass, and the inner diameter of the tip is 0.3mm-1mm, which is similar to the outer diameter of the blood vessel; the material of the negative pressure needle cylinder 5 is glass or metal. The negative pressure needle 6 and the negative pressure syringe 5 can be drawn by hand, or can be made by 3D printing technology.
注射针2由毛细玻璃管拉制而成，注射针2的尖端的内径为0.05mm-0.2mm。此外，在注射针筒1的筒壁上设置有代表体积的刻度值，便于控制注射针筒1内吸入的液体的体积。The injection needle 2 is drawn from a capillary glass tube, and the inner diameter of the tip of the injection needle 2 is 0.05mm-0.2mm. In addition, a scale representing the volume is provided on the wall of the injection syringe 1 to facilitate the control of the volume of the liquid sucked into the injection syringe 1 .
本发明提供的微量液体注射器除了可以用于血管壁等薄壁组织的微量注射外，还可以通过调节负压针6和注射针2的尖端的内径来改造整个注射器，用于注射细胞等；也可以用于其他需要先形成负压后再进行液体等注射的实验。The micro-liquid syringe provided by the present invention can be used for micro-injection of parenchyma such as blood vessel walls, and can also transform the entire syringe by adjusting the inner diameter of the negative pressure needle 6 and the tip of the injection needle 2 for injecting cells, etc.; It can be used in other experiments that need to form a negative pressure before injecting liquids, etc.
显然，本发明的上述实施例仅仅是为了清楚说明本发明所作的举例，而并非是对本发明的实施方式的限定。对于所属领域的普通技术人员来说，在上述说明的基础上还可以做出其它不同形式的变化或变动。这里无需也无法对所有的实施方式予以穷举。凡在本发明的精神和原则之内所作的任何修改、等同替换和改进等，均应包含在本发明权利要求的保护范围之内。Apparently, the above-mentioned embodiments of the present invention are only examples for clearly illustrating the present invention, rather than limiting the implementation of the present invention. For those of ordinary skill in the art, other changes or changes in different forms can be made on the basis of the above description. It is not necessary and impossible to exhaustively list all the implementation manners here. All modifications, equivalent replacements and improvements made within the spirit and principles of the present invention shall be included within the protection scope of the claims of the present invention.
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