CN109045379A - A kind of plasma purification method - Google Patents
A kind of plasma purification method Download PDFInfo
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- CN109045379A CN109045379A CN201810766399.2A CN201810766399A CN109045379A CN 109045379 A CN109045379 A CN 109045379A CN 201810766399 A CN201810766399 A CN 201810766399A CN 109045379 A CN109045379 A CN 109045379A
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- plasma
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0281—Apparatus for treatment of blood or blood constituents prior to transfusion, e.g. washing, filtering or thawing
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Abstract
The invention discloses a kind of plasma purification methods, specifically includes the following steps: S1, plasma dialysis: dialysis membrane is made by film making solution first, then dialysis membrane obtained is mounted on dialysis machine, the plasma solutions of pending purification are slowly poured on dialysis membrane later and are dialysed, S2, filtering: the plasma solutions after the completion of dialysing in S1 are poured into the filtering net cylinder in filter, and filter is started by filter switch, it carries out pivot analysis and filters 20-30min, be related to plasma purification technical field.The plasma purification method, it can be achieved first to dialyse to blood plasma and filter and good electrode separation and adsorption cleaning processing carried out to blood plasma again, greatly enhance clean-up effect, realize in Disease blood plasma blood lipid and harmful substance adequately purified, achieve the purpose that not only quick but also good purified treatment efficiently is carried out to Disease blood plasma, the health for guaranteeing Disease, to greatly facilitate the treatment of Disease.
Description
Technical field
The present invention relates to plasma purification technical field, specially a kind of plasma purification method.
Background technique
The main function of blood plasma is delivery haemocyte, substance needed for transport maintains human life activity and is generated in vivo
Waste etc., blood plasma are equivalent to the cytoplasm of connective tissue, and blood plasma is the important component of blood, are in weak yellow liquid, blood
In the chemical component of slurry, moisture accounts for 90~92%, other 10% based on solute plasma protein, and containing electrolyte, nutrient,
Enzyme, steroids, cholesterol and other important components, plasma protein are the general names of multiple proteins, can be incited somebody to action with salting out method
It is divided into albumin, globulin and fibrinogen three classes, and blood plasma is the extracellular matrix of blood, the composition of blood plasma and its multiple
It is miscellaneous, including protein, lipid, inorganic salts, sugar, amino acid, metabolic waste and a large amount of water, plasma protein are most heavy in blood
The matrix wanted, blood plasma are the liquid components of blood, and haemocyte is suspended in wherein, and the function of plasma proteins has: maintaining blood plasma glue
Body osmotic pressure；Blood buffer system is formed, participates in maintaining blood acid-base balance；Transport nutrition and metabolite, plasma proteins
For hydrophilic colloid, many substances for being insoluble in water are in connection to become substance soluble easily in water；Trophic function, plasma protein decompose
The amino acid of generation can be used for synthetic tissue protein or oxygenolysis supplying energy；Blood coagulation and immunization are participated in, blood plasma
Inorganic salts mainly exist with ionic condition, and since modern life rhythm becomes faster, erratically life, intemperate diet is high
Pionemia patient is more and more, and in addition environmental pollution is increasingly severe, and various poisonous and harmful substances enter human body blood
It in liquid, damages human body and brings various diseases, some Diseases need to carry out purified treatment to the blood plasma in blood, to guarantee
The health of Disease.
It is to directly adopt simple diafiltration processing mostly, however, such blood at present when being purified to blood plasma
Starch purification style clean-up effect it is poor, can not achieve in Disease blood plasma blood lipid and harmful substance carry out adequately it is net
Change, is unable to reach purpose that is not only quick but also efficiently carrying out good purified treatment to Disease blood plasma, can not achieve guarantee
The health of Disease, so that the treatment to Disease brings great inconvenience.
Summary of the invention
(1) the technical issues of solving
In view of the deficiencies of the prior art, the present invention provides a kind of plasma purification method, existing plasma purification is solved
Mode clean-up effect is poor, can not achieve in Disease blood plasma blood lipid and harmful substance adequately purified, can not
Achieve the purpose that not only quick but also good purified treatment efficiently is carried out to Disease blood plasma, can not achieve guarantee Disease
Health, so that the treatment to Disease brings the problem of very big inconvenience.
(2) technical solution
In order to achieve the above object, the present invention is achieved by the following technical programs: a kind of plasma purification method is specific to wrap
Include following steps:
S1, plasma dialysis: dialysis membrane is made by film making solution first, dialysis membrane obtained is then mounted on dialysis and is set
It is standby upper, the plasma solutions of pending purification are slowly poured on dialysis membrane dialyse later；
S2, filtering: the plasma solutions after the completion of dialysing in S1 are poured into the filtering net cylinder in filter, and pass through filtering
Switch starting filter, carries out pivot analysis and filters 20-30min, be later collected filtered plasma filtrate, achievable
Blood lipid in blood plasma is filtered；
S3, electrode separation: plasma filtrate obtained in S2 is poured into electrolytic cell, and by electrode separation equipment anode and
Cathode equipment is inserted into electrolytic cell respectively, and the anode and cathode of electrode separation equipment are carried out power supply energization, positive and negative
Size of current is 0.2-0.6mA/cm2 between pole, powers on and carries out plasma purification as 1-2.5h；
S4, adsorption cleaning: the medical activated carbon for choosing 30g is put into purification tank, then by plasma purification obtained in S3
Liquid pours into purification tank, uniform stirring 1-2h, later that the plasma solutions after the completion of purification are for re-filtering, can be obtained very
Good plasma purification liquid.
Preferably, film making solution is by by the polysulfones of 25wt% and 7wt% polyvinylpyrrolidone in the step S1
It is dissolved in the n-methyl-2-pyrrolidone of 80wt% to obtain homogeneous solution, polyvinylpyrrolidone is to poly- in film making solution
The mixing ratio of sulfone is 35wt%, and film making solution is maintained at 55 DEG C, and with the n-methyl-2-pyrrolidone and 60wt% by 50wt%
Water mixed solution composition internal solution together from mouth discharge is spun, the size of Crossed Circle nozzle is 0.12mm-0.43mm, spray
The temperature of film making solution at mouth is 55 DEG C.
Preferably, the electrode in the step S3 can be selected from material below and be made: silver, silver chlorate, platinum, gold, copper, steel,
Vanadium, tungsten or graphite, and silver-colored electrode using effect the most is best.
Preferably, the preparation process of the medical activated carbon in the step S4 is: the medical activated carbon of 20-30g is first chosen,
Strength detection is carried out to medical activated carbon again, it is complete that progress pickling 20-30min, pickling in hydrochloric acid then is added in medical activated carbon
It adequately cleaned at the rear surface to medical activated carbon, successively carry out coating and high-temperature disinfection treatment respectively later
The preparation of medical activated carbon after the completion.
(3) beneficial effect
The present invention provides a kind of plasma purification methods.Have following the utility model has the advantages that the plasma purification method, specifically includes
Following steps: S1, plasma dialysis: dialysis membrane is made by film making solution first, dialysis membrane obtained is then mounted on dialysis
In equipment, S2, filtering: the plasma solutions after the completion of dialysing in S1 are poured into the filtering net cylinder in filter, and pass through filtering
Switch starting filter, S3, electrode separation: plasma filtrate obtained in S2 is poured into electrolytic cell, and by electrode separation equipment
Anode and cathode equipment be inserted into electrolytic cell respectively, S4, adsorption cleaning: the medical activated carbon for choosing 30g is put into purification tank,
Then plasma purification liquid obtained in S3 is poured into purification tank, it can be achieved that first dialysed and filtered to blood plasma again to blood plasma into
The good electrode separation of row and adsorption cleaning processing, greatly strengthen clean-up effect, realize to the blood in Disease blood plasma
Rouge and harmful substance are adequately purified, and have reached not only quickly but also efficiently carried out well to Disease blood plasma well
The purpose of purified treatment, ensure that the health of Disease, to greatly facilitate the treatment of Disease.
Specific embodiment
Below in conjunction with the embodiment of the present invention, technical scheme in the embodiment of the invention is clearly and completely described,
Obviously, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Based in the present invention
Embodiment, every other embodiment obtained by those of ordinary skill in the art without making creative efforts, all
Belong to the scope of protection of the invention.
The embodiment of the present invention provides a kind of technical solution: a kind of plasma purification method, specifically includes the following steps:
S1, plasma dialysis: dialysis membrane is made by film making solution first, dialysis membrane obtained is then mounted on dialysis and is set
It is standby upper, the plasma solutions of pending purification are slowly poured on dialysis membrane dialyse later；
S2, filtering: the plasma solutions after the completion of dialysing in S1 are poured into the filtering net cylinder in filter, and pass through filtering
Switch starting filter, carries out pivot analysis and filters 20-30min, be later collected filtered plasma filtrate, achievable
Blood lipid in blood plasma is filtered；
S3, electrode separation: plasma filtrate obtained in S2 is poured into electrolytic cell, and by electrode separation equipment anode and
Cathode equipment is inserted into electrolytic cell respectively, and the anode and cathode of electrode separation equipment are carried out power supply energization, positive and negative
Size of current is 0.2-0.6mA/cm2 between pole, powers on and carries out plasma purification as 1-2.5h；
S4, adsorption cleaning: the medical activated carbon for choosing 30g is put into purification tank, then by plasma purification obtained in S3
Liquid pours into purification tank, uniform stirring 1-2h, later that the plasma solutions after the completion of purification are for re-filtering, can be obtained very
Good plasma purification liquid.
In the present invention, film making solution is by the way that the polysulfones of 25wt% and 7wt% polyvinylpyrrolidone is molten in step S1
Solution obtains homogeneous solution in the n-methyl-2-pyrrolidone of 80wt%, and polyvinylpyrrolidone is to polysulfones in film making solution
Mixing ratio be 35wt%, film making solution is maintained at 55 DEG C, and with the n-methyl-2-pyrrolidone and 60wt% by 50wt%
For the internal solution of the mixed solution composition of water together from mouth discharge is spun, the size of Crossed Circle nozzle is 0.12mm-0.43mm, nozzle
The temperature of the film making solution at place is 55 DEG C.
In the present invention, the electrode in step S3 can be selected from material below and be made: silver, silver chlorate, platinum, gold, copper, steel, vanadium,
Tungsten or graphite, and silver-colored electrode using effect the most is best, all negatively charged, the Ke Yitong such as lipoprotein isocolloid particle in blood
Positive charge is crossed to be adsorbed and removed, thus reduce in blood can condensation product, prevent blood viscousness, blood can be made after energization
In negatively charged lipoprotein isocolloid particle etc. migrated to anode, and adsorbed by anode, reach degreasing, purification blood plasma, improve
The purpose of blood plasma quality, the electric current lower than 0.5mA/cm2 will not cause to damage to blood or body cell, in addition, Ag/AgCl electrode
PH value is not influenced, after powering on progress plasma purification, takes out anode, then be ultrasonically treated, being conducive to will be on cathode
Adsorbate is detached from electrode, evenly dispersed to stay in blood plasma.
In the present invention, the preparation process of the medical activated carbon in step S4 is: the medical activated carbon of 20-30g is first chosen, then
Strength detection is carried out to medical activated carbon, then medical activated carbon is added in hydrochloric acid and carries out pickling 20-30min, pickling is completed
The surface of medical activated carbon is adequately cleaned afterwards, successively carries out coating and high-temperature disinfection treatment respectively later, it can be complete
At the preparation of rear medical activated carbon.
It should be noted that, in this document, relational terms such as first and second and the like are used merely to a reality
Body or operation are distinguished with another entity or operation, are deposited without necessarily requiring or implying between these entities or operation
In any actual relationship or order or sequence.Moreover, the terms "include", "comprise" or its any other variant are intended to
Non-exclusive inclusion, so that the process, method, article or equipment including a series of elements is not only wanted including those
Element, but also including other elements that are not explicitly listed, or further include for this process, method, article or equipment
Intrinsic element.
It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with
A variety of variations, modification, replacement can be carried out to these embodiments without departing from the principles and spirit of the present invention by understanding
And modification, the scope of the present invention is defined by the appended.
Claims (4)
1. a kind of plasma purification method, it is characterised in that: specifically includes the following steps:
S1, plasma dialysis: dialysis membrane is made by film making solution first, dialysis membrane obtained is then mounted on dialysis machine
On, the plasma solutions of pending purification are slowly poured on dialysis membrane dialyse later；
S2, filtering: the plasma solutions after the completion of dialysing in S1 are poured into the filtering net cylinder in filter, and pass through filter switch
Start filter, carries out pivot analysis and filter 20-30min, be later collected filtered plasma filtrate, it is achievable by blood
Blood lipid in slurry is filtered；
S3, electrode separation: plasma filtrate obtained in S2 is poured into electrolytic cell, and by the anode and cathode of electrode separation equipment
Equipment is inserted into electrolytic cell respectively, and by electrode separation equipment anode and cathode carry out power supply energization, anode and cathode it
Between size of current be 0.2-0.6mA/cm2, power on carry out plasma purification be 1-2.5h；
S4, adsorption cleaning: the medical activated carbon for choosing 30g is put into purification tank, then falls plasma purification liquid obtained in S3
Enter in purification tank, uniform stirring 1-2h is for re-filtering by the plasma solutions after the completion of purification later, can be obtained well
Plasma purification liquid.
2. a kind of plasma purification method according to claim 1, it is characterised in that: film making solution is logical in the step S1
It crosses and the polysulfones of 25wt% and 7wt% polyvinylpyrrolidone is dissolved in the n-methyl-2-pyrrolidone of 80wt% to obtain
Homogeneous solution, polyvinylpyrrolidone is 35wt% to the mixing ratio of polysulfones in film making solution, and film making solution is maintained at 55 DEG C, and
From spinning mouth row together with the internal solution that the mixed solution of the water of the n-methyl-2-pyrrolidone and 60wt% by 50wt% forms
Out, the size of Crossed Circle nozzle is 0.12mm-0.43mm, and the temperature of the film making solution at nozzle is 55 DEG C.
3. a kind of plasma purification method according to claim 1, it is characterised in that: the electrode in the step S3 can be selected from
Material below is made: silver, silver chlorate, platinum, gold, copper, steel, vanadium, tungsten or graphite, and silver-colored electrode using effect the most is best.
4. a kind of plasma purification method according to claim 1, it is characterised in that: the medical activated carbon in the step S4
Preparation process be: first choose 20-30g medical activated carbon, then to medical activated carbon carry out strength detection, then by medical work
Property charcoal be added in hydrochloric acid and carry out pickling 20-30min, the surface of medical activated carbon adequately cleaned after the completion of pickling, it
It successively carries out coating and high-temperature disinfection treatment respectively afterwards, the preparation of rear medical activated carbon can be completed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810766399.2A CN109045379A (en) | 2018-07-12 | 2018-07-12 | A kind of plasma purification method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810766399.2A CN109045379A (en) | 2018-07-12 | 2018-07-12 | A kind of plasma purification method |
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| CN109045379A true CN109045379A (en) | 2018-12-21 |
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|---|---|---|---|---|
| CN1341460A (en) * | 2001-09-20 | 2002-03-27 | 上海江夏血液技术有限公司 | Method for producing blood-fat in blood plasma |
| CN2507460Y (en) * | 2001-01-15 | 2002-08-28 | 北京京精医疗设备有限公司 | Full-enclosed external blood fat removing apparatus |
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| CN1611273A (en) * | 2003-10-31 | 2005-05-04 | 上海建福生物技术有限公司 | Extracorporeal blood dialysis filtering method and apparatus for treating cerebral apoplexy |
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| CN100998898A (en) * | 2006-12-29 | 2007-07-18 | 上海达华医疗器械有限公司 | Multifunction in-vitro blood therapeutic instrument |
| CN101041092A (en) * | 2007-04-27 | 2007-09-26 | 高光勇 | Multiple organ dysfunction and support system |
| CN103402563A (en) * | 2010-11-02 | 2013-11-20 | Ic创新有限公司 | Electrosorption and decomposition device for the purification of blood and other fluids |
| CN204411380U (en) * | 2015-01-13 | 2015-06-24 | 倪自谦 | A kind of blood-lipoids material specific adsorption device |
| CN107693873A (en) * | 2017-11-01 | 2018-02-16 | 桂林欣中伊健康产业有限公司 | Plasma purification simple and easy method |
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2018
- 2018-07-12 CN CN201810766399.2A patent/CN109045379A/en active Pending
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2507460Y (en) * | 2001-01-15 | 2002-08-28 | 北京京精医疗设备有限公司 | Full-enclosed external blood fat removing apparatus |
| CN1341460A (en) * | 2001-09-20 | 2002-03-27 | 上海江夏血液技术有限公司 | Method for producing blood-fat in blood plasma |
| CN1684727A (en) * | 2002-09-12 | 2005-10-19 | 旭化成医疗有限公司 | Plasma purifying membrane and plasma purifying system |
| CN1488410A (en) * | 2002-10-11 | 2004-04-14 | 南京红十字血液中心 | Method for specific adsorption of low density fat-cholesterine in hyperlipemia |
| CN1611273A (en) * | 2003-10-31 | 2005-05-04 | 上海建福生物技术有限公司 | Extracorporeal blood dialysis filtering method and apparatus for treating cerebral apoplexy |
| CN100998898A (en) * | 2006-12-29 | 2007-07-18 | 上海达华医疗器械有限公司 | Multifunction in-vitro blood therapeutic instrument |
| CN101041092A (en) * | 2007-04-27 | 2007-09-26 | 高光勇 | Multiple organ dysfunction and support system |
| CN103402563A (en) * | 2010-11-02 | 2013-11-20 | Ic创新有限公司 | Electrosorption and decomposition device for the purification of blood and other fluids |
| CN204411380U (en) * | 2015-01-13 | 2015-06-24 | 倪自谦 | A kind of blood-lipoids material specific adsorption device |
| CN107693873A (en) * | 2017-11-01 | 2018-02-16 | 桂林欣中伊健康产业有限公司 | Plasma purification simple and easy method |
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Application publication date: 20181221 |
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