CN108866645B - Tubular support collection device for electrostatic spinning and electrostatic spinning equipment - Google Patents
Tubular support collection device for electrostatic spinning and electrostatic spinning equipment Download PDFInfo
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- CN108866645B CN108866645B CN201810724107.9A CN201810724107A CN108866645B CN 108866645 B CN108866645 B CN 108866645B CN 201810724107 A CN201810724107 A CN 201810724107A CN 108866645 B CN108866645 B CN 108866645B
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- tubular
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- 238000010041 electrostatic spinning Methods 0.000 title description 18
- 230000005540 biological transmission Effects 0.000 claims abstract description 31
- 238000001523 electrospinning Methods 0.000 claims abstract description 16
- 230000007246 mechanism Effects 0.000 claims abstract description 11
- 230000008878 coupling Effects 0.000 claims abstract description 9
- 238000010168 coupling process Methods 0.000 claims abstract description 9
- 238000005859 coupling reaction Methods 0.000 claims abstract description 9
- 230000009471 action Effects 0.000 claims abstract description 8
- 239000000835 fiber Substances 0.000 claims abstract description 7
- 230000005684 electric field Effects 0.000 claims abstract description 4
- 238000009987 spinning Methods 0.000 claims description 11
- 239000000725 suspension Substances 0.000 claims 1
- 230000002792 vascular Effects 0.000 description 6
- 239000002121 nanofiber Substances 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 210000004204 blood vessel Anatomy 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 208000024172 Cardiovascular disease Diseases 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000000452 restraining effect Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 108060003393 Granulin Proteins 0.000 description 1
- 238000005267 amalgamation Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229920001222 biopolymer Polymers 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 210000004351 coronary vessel Anatomy 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 210000005167 vascular cell Anatomy 0.000 description 1
Images
Classifications
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/0007—Electro-spinning
- D01D5/0061—Electro-spinning characterised by the electro-spinning apparatus
- D01D5/0076—Electro-spinning characterised by the electro-spinning apparatus characterised by the collecting device, e.g. drum, wheel, endless belt, plate or grid
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/0007—Electro-spinning
- D01D5/0061—Electro-spinning characterised by the electro-spinning apparatus
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- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Textile Engineering (AREA)
- Prostheses (AREA)
- Spinning Methods And Devices For Manufacturing Artificial Fibers (AREA)
Abstract
本发明涉及静电纺丝的技术领域，更具体地，涉及静电纺丝管状支架收集装置及静电纺丝设备，包括支撑架以及转动连接于支撑架的收集器，收集器包括分体式管状结构以及用于约束分体式管状结构的联轴器，联轴器可拆卸连接于分体式管状结构的两端；分体式管状结构的一端连接有传动机构，传动机构连接有驱动电机；分体式管状结构为导电结构，分体式管状结构上施加有负电压，从正电压端释放的带电射流分裂形成的纤维因电场力的作用而定向收集于分体式管状结构的外表面。本发明的分体式管状结构在联轴器的固定下为柱体，解开联轴器的约束后分体式管状结构分体，能够轻易地将管状支架取出而不破坏管状支架的原本样貌，解决了管状支架难以取出的问题。
The present invention relates to the technical field of electrospinning, and more particularly, to an electrospinning tubular stent collecting device and electrospinning equipment, comprising a support frame and a collector rotatably connected to the support frame. The collector includes a split tubular structure and a The coupling for constraining the split tubular structure, the coupling can be detachably connected to both ends of the split tubular structure; one end of the split tubular structure is connected with a transmission mechanism, and the transmission mechanism is connected with a drive motor; the split tubular structure is conductive Structure, a negative voltage is applied to the split tubular structure, and the fibers formed by the splitting of the charged jet released from the positive voltage end are oriented and collected on the outer surface of the split tubular structure due to the action of the electric field force. The split tubular structure of the present invention is a cylinder under the fixing of the coupling, and the split tubular structure is split after the constraint of the coupling is released, and the tubular support can be easily taken out without destroying the original appearance of the tubular support. The problem that the tubular stent is difficult to take out is solved.
Description
Technical Field
The invention relates to the technical field of electrostatic spinning, in particular to an electrostatic spinning tubular support collecting device and electrostatic spinning equipment.
Background
Cardiovascular diseases are one of the main causes of human death, particularly coronary artery diseases account for 53 percent of the total death rate of cardiovascular diseases, and surgical replacement or bypass transplantation is the main means for treating diseases such as coronary arteries. Autologous blood vessels and artificially synthesized blood vessels are clinically main vascular grafts, but the autologous blood vessels have limited sources and are difficult to meet clinical requirements. The vascular tissue engineering technology provides a new source for small-diameter vascular grafts, and the idea is to construct a functional small-diameter vascular substitute with bioactivity by utilizing the composite culture of vascular cells and a degradable stent. The degradable stent plays an important supporting role in cell growth and tissue reconstruction, and the preparation of an ideal vascular stent is the key of vascular tissue engineering.
The electrostatic spinning technology is a simple, convenient and feasible preparation method of a novel porous scaffold, and can form nano-to submicron-grade fibers. The electrospinning parameters are easy to control, the diameter of the formed fiber is similar to that of structural matrix protein (50 nm-500 nm) in natural tissues, in addition, the fiber has high specific surface area and high porosity and simulates an extracellular matrix structure, a good growth environment can be provided for cells, and in addition, tubular structures with different diameters can be obtained by designing a receiving device, so that the electrospinning technology can be widely applied to intravascular stent preparation. However, after the biopolymer material is collected into a tubular structure of nanofibers formed by electrospinning, the tubular structure becomes a tubular scaffold with a certain thickness, and the nanofibers in the tubular scaffold are tightly attached to the tubular collecting device, so that it is difficult to separate and take out the tubular scaffold from the collecting device without any damage. The applicant can increase the accessibility of the tubular stent by adding the lubricant to the tubular collection device, but the added substance destroys the original appearance of the tubular stent to some extent, and the subsequent lubricant removal treatment also increases the experimental steps.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide an electrostatic spinning tubular stent collecting device, which uses a split-type tubular collector to collect a tubular stent, can easily take out the tubular stent without damaging the original appearance of the tubular stent and solves the problem that the tubular stent is difficult to take out.
In order to solve the technical problems, the invention adopts the technical scheme that:
the electrostatic spinning tubular support collecting device comprises a supporting frame and a collector which is rotatably connected to the supporting frame, wherein the collector comprises a split tubular structure and a coupler used for restraining the split tubular structure, and the coupler is detachably connected to two ends of the split tubular structure; one end of the split tubular structure is connected with a transmission mechanism, and the transmission mechanism is connected with a driving motor; the split type tubular structure is a conductive structure, negative voltage is applied to the split type tubular structure, and fibers formed by splitting of the charged jet released from the positive voltage end are directionally suspended above the split type tubular structure due to the action of electric field force.
The electrostatic spinning tubular support collecting device adopts the split type tubular structure to collect the tubular support, the split type tubular structure is a cylinder under the fixation of the coupler, the split type tubular structure is split after the constraint of the coupler is released, the tubular support can be easily taken out without damaging the original appearance of the tubular support, and the problem that the tubular support is difficult to take out is solved.
Furthermore, the split type tubular structure is formed by assembling a plurality of columns with sector-shaped cross sections, the sum of central angles of the columns is 360 degrees, and the sector-shaped radiuses of the cross sections of the columns are equal. The split type tubular structure is a cylinder under the fixation of the coupler, and the dispersed cylinders can be easily drawn out from the interior of the tubular support without damaging the original appearance of the tubular support after leaving the coupler.
Furthermore, the split tubular structure is formed by splicing four columns with sector cross sections, and the central angle of each column is 90 degrees. The cylinder that sets up like this processes conveniently, practices thrift the processing cost, agrees with well, can guarantee that split type tubular structure outward appearance is smooth when the amalgamation, improves the shaping quality of tubulose support.
Furthermore, the outer wall of the split tubular structure is uniformly sprayed with an anti-sticking layer. The non-stick layer can increase the accessibility of the tubular support, further avoid damaging the original appearance of the tubular support, is stable in property and does not influence the experimental steps.
Further, drive mechanism is belt pulley transmission, including the action wheel, follow driving wheel and encircle in the action wheel, follow the belt of driving wheel periphery, action wheel, follow driving wheel install in support frame one side. The driving motor drives the driving wheel to rotate, the driving wheel drives the driven wheel to rotate under the action of the belt, and the driven wheel drives the split tubular structure collector to rotate to collect the nanofibers.
Furthermore, the driving motor is a direct current motor with adjustable rotating speed, an output shaft of the direct current motor is connected with the center of the driving wheel, the driven wheel is connected with a transmission shaft, and the transmission shaft is connected with a coupler. The rotation speed of the collector can be adjusted by the arrangement of the adjustable rotation speed of the direct current motor, so that the thickness of the tubular support can be controlled.
Furthermore, the transmission shaft is arranged on the support frame, and a bearing is arranged at the joint of the transmission shaft and the support frame. The setting of bearing can reduce the wearing and tearing that lead to the support frame when transmission shaft and support frame rotate relatively, prolongs collection device's life.
Furthermore, the two groups of support frames are arranged oppositely; the split type tubular structure is rotatably connected between the two groups of support frames. Set up like this and to increase the stability that the support frame supported, split type tubular structure supports between two sets of support frames, can rotate steadily, improves the quality of tubulose support.
Furthermore, the support frame includes mounting panel and the connecting plate of vertical connection, the mounting panel level sets up, the one end that the mounting panel was kept away from to the connecting plate is equipped with the smooth semi-circular structure of outline. Can set up the mounting hole as required on the mounting panel, semicircular structure's setting is outward appearance pleasing to the eye on the one hand, can effectively avoid the injury that causes operating personnel on the one hand.
The invention also provides electrostatic spinning equipment, which comprises the tubular bracket collecting device, a direct-current power supply, a spinning needle head connected to the positive voltage end of the direct-current power supply and an injection pump communicated with the spinning needle head, wherein the tubular bracket collecting device is connected to the negative voltage end of the high-voltage power supply; the spinning needle head is arranged above the split type tubular structure and used for ejecting the charged solution towards the tubular support collecting device.
Compared with the prior art, the invention has the beneficial effects that:
(1) the electrostatic spinning tubular support collecting device provided by the invention collects the tubular supports by using the collector formed by splicing the split tubular structures, the split tubular structures are cylindrical under the fixation of the coupler, the split tubular structures separated from the coupler can be easily taken out of the tubular supports without damaging the original appearance of the tubular supports, and the problem that the tubular supports are difficult to take out is solved.
(2) According to the electrostatic spinning tubular stent collecting device, the non-stick layer is sprayed on the outer wall of the split type tubular structure, so that the accessibility of the tubular stent can be increased, the original appearance of the tubular stent is further prevented from being damaged, the property of the non-stick layer is stable, and the steps of an experiment are not influenced.
Drawings
Fig. 1 is a schematic structural view of an electrospinning device according to a second embodiment.
Fig. 2 is a schematic structural diagram of a separated tubular structure in the first embodiment.
In the drawings: 1-a syringe pump; 2-spinning needle head; 3-driving a motor; 4-a transmission device; 41-driving wheel; 42-a belt; 43-a driven wheel; 5-a support frame; 6-split tubular structure; 7-a transmission shaft; 8-a coupler; 9-direct current power supply.
Detailed Description
The present invention will be further described with reference to the following embodiments. Wherein the showings are for the purpose of illustration only and are shown by way of illustration only and not in actual form, and are not to be construed as limiting the present patent; to better illustrate the embodiments of the present invention, some parts of the drawings may be omitted, enlarged or reduced, and do not represent the size of an actual product; it will be understood by those skilled in the art that certain well-known structures in the drawings and descriptions thereof may be omitted.
The same or similar reference numerals in the drawings of the embodiments of the present invention correspond to the same or similar components; in the description of the present invention, it should be understood that if there is an orientation or positional relationship indicated by the terms "upper", "lower", "left", "right", etc. based on the orientation or positional relationship shown in the drawings, it is only for convenience of describing the present invention and simplifying the description, but it is not intended to indicate or imply that the referred device or element must have a specific orientation, be constructed in a specific orientation, and be operated, and therefore, the terms describing the positional relationship in the drawings are only used for illustrative purposes and are not to be construed as limiting the present patent, and the specific meaning of the terms may be understood by those skilled in the art according to specific circumstances.
Example one
As shown in fig. 1 to 2, a first embodiment of the electrostatic spinning tubular stent collecting device of the present invention comprises a support frame 5 and a collector rotatably connected to the support frame 5, wherein the collector comprises a split tubular structure 6 and a coupling 8 for restraining the split tubular structure 6, and the coupling 8 is detachably connected to two ends of the split tubular structure 6; one end of the split tubular structure 6 is connected with a transmission mechanism, and the transmission mechanism is connected with a driving motor 3; the split type tubular structure 6 is a conductive structure, negative voltage is applied to the split type tubular structure 6, and fibers formed by splitting of charged jet released from a positive voltage end are directionally suspended above the split type tubular structure 6 due to the action of electric field force.
In the implementation of the embodiment, the split-type tubular structure 6 is a cylinder under the fixation of the coupler 8, and after the constraint of the coupler 8 is released, the split-type tubular structure 6 is split, so that the tubular support can be easily taken out without damaging the original appearance of the tubular support, and the problem that the tubular support is difficult to take out is solved.
The split tubular structure 6 is formed by assembling a plurality of columns with sector-shaped cross sections, the sum of central angles of the columns is 360 degrees, and the sector-shaped radiuses of the cross sections of the columns are equal. The split tubular structure 6 in this embodiment is formed by assembling four columns with sector cross sections, and the central angle of each column is 90 °. The split type tubular structure 6 has the advantages of convenient processing, processing cost saving, good fit, capability of ensuring smooth appearance of the split type tubular structure 6 during splicing and improvement on the molding quality of the tubular support.
For the convenience of increasing the separation of the tubular support and the split type tubular structure 6, the outer wall of the split type tubular structure 6 is uniformly coated with an anti-sticking layer. The retrievability of the tubular stent can be improved, the original appearance of the tubular stent is further prevented from being damaged, the property of the non-stick layer is stable, and the steps of an experiment are not influenced.
As shown in fig. 1, the transmission mechanism is a belt pulley transmission device 4, and includes a driving wheel, a driven wheel and a belt surrounding the periphery of the driving wheel and the driven wheel, and the driving wheel and the driven wheel are installed on one side of the support frame 5. The driving motor 3 is a direct current motor with adjustable rotating speed, an output shaft of the direct current motor is connected with the center of the driving wheel, the driven wheel is connected with a transmission shaft 7, and the transmission shaft 7 is connected with a coupler 8; the transmission shaft 7 is arranged on the support frame 5, and a bearing is arranged at the joint of the transmission shaft 7 and the support frame 5.
The two groups of support frames 5 are arranged oppositely, and the split type tubular structure 6 is rotatably connected between the two groups of support frames 5; can increase the stability that support 5 supported, support split type tubular structure 6 between two sets of support frames 5, can the steady rotation, can improve the quality of tubulose support. The supporting frame 5 comprises a mounting plate and a connecting plate which are vertically connected, the mounting plate is horizontally arranged, and one end, far away from the mounting plate, of the connecting plate is provided with a semicircular structure with a smooth outer contour; can set up the mounting hole as required on the mounting panel of this embodiment, semicircular structure's setting is outward appearance pleasing to the eye on the one hand, can effectively avoid the injury that causes operating personnel on the one hand.
Example two
Fig. 1 shows an embodiment of the electrospinning device of the present invention, comprising the tubular stent collecting device as described above, a dc power supply 9, a spinning needle 2 connected to the positive voltage end of the dc power supply 9, and an injection pump 1 communicated with the spinning needle 2, wherein the tubular stent collecting device is connected to the negative voltage end of the high voltage power supply; the spinning needle head 2 is arranged above the split type tubular structure 6 and used for ejecting the charged solution to the tubular support collecting device.
In the embodiment, before electrostatic spinning, the split-type tubular structure 6 is synthesized into a cylinder and is fixed by the coupler 8, the cylinder is installed on the transmission shafts 7 on two sides of the support frame 5 through the other end of the coupler 8, then a power supply is turned on, the injection pump 1 and the direct current motor carry out electrostatic spinning, and the direct current motor drives the split-type tubular structure 6 to rotate through the transmission device 4 and the transmission shafts 7 to collect nano fibers; after the electrostatic spinning is finished, the split type tubular structure 6 is taken out from the coupler 8, the split type tubular structure 6 without constraint can be separated from the tubular support one by one through slight displacement until the split type tubular structure is completely removed, and finally the intact tubular support can be obtained.
It should be understood that the above-described embodiments of the present invention are merely examples for clearly illustrating the present invention, and are not intended to limit the embodiments of the present invention. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. Any modification, equivalent replacement, and improvement made within the spirit and principle of the present invention should be included in the protection scope of the claims of the present invention.
Claims (8)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810724107.9A CN108866645B (en) | 2018-07-04 | 2018-07-04 | Tubular support collection device for electrostatic spinning and electrostatic spinning equipment |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810724107.9A CN108866645B (en) | 2018-07-04 | 2018-07-04 | Tubular support collection device for electrostatic spinning and electrostatic spinning equipment |
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| Publication Number | Publication Date |
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| CN108866645A CN108866645A (en) | 2018-11-23 |
| CN108866645B true CN108866645B (en) | 2021-02-19 |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN200985371Y (en) * | 2006-08-21 | 2007-12-05 | 福建师范大学 | Cylindrical collector used in static electricity spinning equipment |
| CN101363137A (en) * | 2008-09-24 | 2009-02-11 | 重庆大学 | An electrospinning device for preparing aligned nanofibers |
| CN203034156U (en) * | 2013-01-10 | 2013-07-03 | 南京市鼓楼医院 | Collection device of electrostatic spinning |
| CN204474807U (en) * | 2015-01-24 | 2015-07-15 | 哈尔滨理工大学 | A kind of electrostatic spinning receiving system of replaceable multiple diameter collection cylinder |
| WO2016163651A1 (en) * | 2015-04-09 | 2016-10-13 | 울산과학기술원 | Electrospinning apparatus using drum collector and transparent electrode preparation method using same |
-
2018
- 2018-07-04 CN CN201810724107.9A patent/CN108866645B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN200985371Y (en) * | 2006-08-21 | 2007-12-05 | 福建师范大学 | Cylindrical collector used in static electricity spinning equipment |
| CN101363137A (en) * | 2008-09-24 | 2009-02-11 | 重庆大学 | An electrospinning device for preparing aligned nanofibers |
| CN203034156U (en) * | 2013-01-10 | 2013-07-03 | 南京市鼓楼医院 | Collection device of electrostatic spinning |
| CN204474807U (en) * | 2015-01-24 | 2015-07-15 | 哈尔滨理工大学 | A kind of electrostatic spinning receiving system of replaceable multiple diameter collection cylinder |
| WO2016163651A1 (en) * | 2015-04-09 | 2016-10-13 | 울산과학기술원 | Electrospinning apparatus using drum collector and transparent electrode preparation method using same |
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| CN108866645A (en) | 2018-11-23 |
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