CN108801367A - A kind of environmental detection set and its manufacturing method suitable for poct class diagnostic reagents - Google Patents
A kind of environmental detection set and its manufacturing method suitable for poct class diagnostic reagents Download PDFInfo
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- CN108801367A CN108801367A CN201811045309.7A CN201811045309A CN108801367A CN 108801367 A CN108801367 A CN 108801367A CN 201811045309 A CN201811045309 A CN 201811045309A CN 108801367 A CN108801367 A CN 108801367A
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- humidity
- chromogenic reaction
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- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 14
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- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 6
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 6
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- KXGFMDJXCMQABM-UHFFFAOYSA-N 2-methoxy-6-methylphenol Chemical compound [CH]OC1=CC=CC([CH])=C1O KXGFMDJXCMQABM-UHFFFAOYSA-N 0.000 description 2
- 229920000178 Acrylic resin Polymers 0.000 description 2
- 239000004925 Acrylic resin Substances 0.000 description 2
- GSNUFIFRDBKVIE-UHFFFAOYSA-N DMF Natural products CC1=CC=C(C)O1 GSNUFIFRDBKVIE-UHFFFAOYSA-N 0.000 description 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 2
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 description 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 2
- 239000013032 Hydrocarbon resin Substances 0.000 description 2
- 239000004640 Melamine resin Substances 0.000 description 2
- 229920000877 Melamine resin Polymers 0.000 description 2
- 239000004952 Polyamide Substances 0.000 description 2
- 229920006387 Vinylite Polymers 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- HGAZMNJKRQFZKS-UHFFFAOYSA-N chloroethene;ethenyl acetate Chemical compound ClC=C.CC(=O)OC=C HGAZMNJKRQFZKS-UHFFFAOYSA-N 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 229920002313 fluoropolymer Polymers 0.000 description 2
- 239000004811 fluoropolymer Substances 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 125000004836 hexamethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[*:1] 0.000 description 2
- 229920006270 hydrocarbon resin Polymers 0.000 description 2
- 239000003094 microcapsule Substances 0.000 description 2
- 239000005416 organic matter Substances 0.000 description 2
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 2
- 239000005011 phenolic resin Substances 0.000 description 2
- 229920001568 phenolic resin Polymers 0.000 description 2
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 2
- 229920002647 polyamide Polymers 0.000 description 2
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- 229920000570 polyether Polymers 0.000 description 2
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- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 2
- 229920001451 polypropylene glycol Polymers 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- ZPLCXHWYPWVJDL-UHFFFAOYSA-N 4-[(4-hydroxyphenyl)methyl]-1,3-oxazolidin-2-one Chemical compound C1=CC(O)=CC=C1CC1NC(=O)OC1 ZPLCXHWYPWVJDL-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical class [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 description 1
- 241000282941 Rangifer tarandus Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01D—MEASURING NOT SPECIALLY ADAPTED FOR A SPECIFIC VARIABLE; ARRANGEMENTS FOR MEASURING TWO OR MORE VARIABLES NOT COVERED IN A SINGLE OTHER SUBCLASS; TARIFF METERING APPARATUS; MEASURING OR TESTING NOT OTHERWISE PROVIDED FOR
- G01D21/00—Measuring or testing not otherwise provided for
- G01D21/02—Measuring two or more variables by means not covered by a single other subclass
Landscapes
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Inks, Pencil-Leads, Or Crayons (AREA)
Abstract
The invention discloses a kind of environmental detection set and its manufacturing method suitable for poct class diagnostic reagents, environmental detection set, including：Temperature colour developing item and the humidity chromogenic item being fixed on poct class diagnostic reagent carriers.Temperature and Humidity reaction paste is printed by screen printing technique, is dried, is fixed on poct class diagnostic reagent carriers by the present invention, convenient for users to voluntarily judging whether the humiture of poct classes diagnostic reagent environment when in use meets product technology requirement；Humiture identification point is simple in structure, and judgment method is intuitive, is easy observation, also brings facility to the use of operator.
Description
Technical field
The present invention relates to poct diagnostic fields, the detection device of especially a kind of auxiliary poct diagnostic reagents detection environment and
Its manufacturing method.
Background technology
Poct refers to a kind of diagnostic check carried out by non-Lab workers.Close at Case treatment, by not receiving
The clinical laboratory inspection that the clinical staff of clinical labororatory's subject training or patient's (self detection) carry out.Poct is to pass
The at-once monitor equipment of the inspection carried out other than system, core or central laboratory.The check system of poct will be closer to trouble at present
Person is simultaneously distributed in hospital, community clinic and familial self monitoring field etc..
Poct class diagnostic reagents have easy to operate, field monitoring, sample disposal require it is low, quickly provide result, examine
As a result the advantages that being comparable.Small-sized testing instruments are usually applicable in, are clinical examination center high pass amount, large automatic inspection
Strong supplement, have the characteristics that certain.But many poct class diagnostic reagents are very big by environmental influence.It is commented using room interstitial
Whether testing result of the sample under different humitures reaches in the standard of biochemical instruments test value (target value), and conclusion is test environment
Humiture is affected to poct class diagnostic reagent testing results.
Poct class diagnostic reagents have it is small, it is easy to carry, test out the result time is short, sample disposal require it is low excellent
Point is widely applied to the fields such as hospital, community clinic and household self-monitoring at present.Poct class diagnostic reagents divide when detecting
For two classes, for one kind there is provided a kind of detector, which provides testing result.One kind is the diagnosis examination of poct classes
Agent does not have the participation of detector, individually provides testing result.Poct classes diagnostic reagent when detecting, can directly display test knot
Fruit, but poct classes diagnostic reagent can have the following disadvantages when detecting：It cannot ensure whether the test environment of user meets poct
The requirement of class diagnostic reagent technology, if the test environment of user does not operate under desired test environment, will eventually influence
The accuracy of testing result.
Market needs a kind of poct diagnostic reagents of included temperature-humidity detecting device, can allow user's voluntarily discriminating test ring
Whether the humiture in border meets the requirement of poct class diagnostic reagent technologies, and the present invention solves this problem.
Invention content
To solve the deficiencies in the prior art, the purpose of the present invention is to provide a kind of rings suitable for poct class diagnostic reagents
Temperature and Humidity item is arranged, convenient for users to voluntarily in border detection device and its manufacturing method on poct class diagnostic reagent carriers
Whether the humiture of judgement poct classes diagnostic reagent environment when in use meets product technology requirement；Humiture identification point structure
Simply, judgment method is intuitive, is easy observation, also brings facility to the use of operator.
In order to realize that above-mentioned target, the present invention adopt the following technical scheme that：
A kind of environmental detection set suitable for poct class diagnostic reagents, including：It is fixed on poct class diagnostic reagent carriers
On temperature develop the color item.
A kind of environmental detection set suitable for poct class diagnostic reagents above-mentioned, temperature develop the color item by temperature chromogenic reaction
Slurry is formed；Temperature chromogenic reaction slurry has according to mass percent composition：The solvent of 57%-63%, the tree of 27%-33%
Fat, the surfactant of 0.3%-0.9%, the temperature-sensitive toner of 7%-13%；Temperature-sensitive toner is passed through by Reversible Thermochromic Compounds
Electronics transfer is prepared.
A kind of environmental detection set suitable for poct class diagnostic reagents, which is characterized in that including：Poct classes are fixed on to examine
Humidity chromogenic item on disconnected reagent carrier.
A kind of environmental detection set suitable for poct class diagnostic reagents above-mentioned, humidity chromogenic item are reacted by humidity chromogenic
Slurry is formed；Humidity chromogenic reaction paste has according to mass percent composition：The solvent of 57%-63%, the tree of 27%-33%
Fat, the surfactant of 0.3%-0.9%, the wet toner of sense of 7%-13%；Feel wet toner to be placed in silicon substrate carrier by colorant
It is prepared.
A kind of environmental detection set suitable for poct class diagnostic reagents, including：It is fixed on poct class diagnostic reagent carriers
On temperature colour developing item and humidity chromogenic item.
A kind of environmental detection set suitable for poct class diagnostic reagents above-mentioned, temperature develop the color item by temperature chromogenic reaction
Slurry is formed；The temperature chromogenic reaction slurry has according to mass percent composition：The solvent of 57-63%, the tree of 27-33%
Fat, the surfactant of 0.3%-0.9%, the temperature-sensitive toner of 7%-13%；Temperature-sensitive toner is passed through by Reversible Thermochromic Compounds
Electronics transfer is prepared.
Humidity chromogenic item is formed by humidity chromogenic reaction paste；The humidity chromogenic reaction paste is according to mass percent group
Cheng You：The solvent of 57-63%, the resin of 27-33%, the surfactant of 0.3%-0.9%, the wet toner of sense of 7%-13%；
Feel wet toner and be placed in silicon substrate carrier by colorant and is prepared.
A kind of manufacturing method of environmental detection set suitable for poct class diagnostic reagents, including：
Configure temperature chromogenic reaction slurry；Temperature colour developing item is formed by temperature chromogenic reaction slurry；Temperature chromogenic reaction is starched
Material has according to mass percent composition：The solvent of 57-63%, the resin of 27-33%, the surfactant of 0.3%-0.9%,
The temperature-sensitive toner of 7%-13%；Temperature-sensitive toner is prepared by Reversible Thermochromic Compounds by electronics transfer；By solvent, tree
Fat, surfactant, temperature-sensitive toner are in uniform flow-like according to proportioning successively uniform dissolution；
Configure humidity chromogenic reaction paste；Humidity chromogenic item is formed by humidity chromogenic reaction paste；Humidity chromogenic reaction slurry
Material has according to mass percent composition：The solvent of 57-63%, the resin of 27-33%, the surfactant of 0.3%-0.9%,
The wet toner of sense of 7%-13%；Feel wet toner and be placed in silicon substrate carrier by colorant and is prepared；By solvent, resin, surface is lived
Property agent, feel wet toner according to proportioning uniform dissolution successively, be in uniform flow-like；
The temperature chromogenic reaction slurry, humidity chromogenic reaction paste are printed on poct classes and examined by screen printing technique
On the carrier of disconnected reagent；
Carrier after printing is placed in baker and cured, dried.
A kind of manufacturing method of environmental detection set suitable for poct class diagnostic reagents above-mentioned,
Screen printing technique is using film thickness 20um, 300 mesh of mesh number, 22.5 ° of angle, the silk printing screen of 21 ± 1N of tension
Version；
A kind of manufacturing method of environmental detection set suitable for poct class diagnostic reagents above-mentioned, before silk-screen printing,
It needs to adjust screen printer print parameter；
Specific silk-screen parameter is as follows：Screen printer air pressure should be within the scope of 6.0 ± 1.0Bar；It is required that silk-screen figure is in scraper
Center and, the angle of scraper and halftone parallel with scraper：75°；The speed of service：240mm/s±100mm/s；The fortune of ink-retruning blade
Scanning frequency degree：240mm/s±100mm/s；Table top halftone spacing：4.0mm±1.0mm.
A kind of manufacturing method of environmental detection set suitable for poct class diagnostic reagents above-mentioned, baker are dried using IR
Main line, drying, solidification design parameter are as follows：
Spin manifold temperature is set as 110 DEG C, and the temperature in oven body is made to control at 110 DEG C ± 2 DEG C；
Transmission net tape speed：Ensure that by the time for keeping the temperature effective coverage be 6 ± 1min；Corresponding guipure speed is 0.8
M/min.
The invention has the beneficial effects that：
Temperature and Humidity item is set on poct class diagnostic reagent carriers, convenient for users to voluntarily judging the diagnosis examination of poct classes
Whether the humiture of agent environment when in use meets product technology requirement；
Temperature and Humidity item is fixed on carrier by the present invention by screen printing technique, and plate-making is easy with printing process,
Equipment investment is few, at low cost.It is not limited by printing species, size, shape.The ink and coating of different solvents can be selected
Adapt to the printing of different type stock, and due to silk-screen plate softness, required printing pressure is small, can carry out curved surface, breakable object
Printing.Printer's ink thickness, bright in luster, three-dimensional sense and strong covering power.4. not limited by ink and diluent, can print resistance to
The strong printed matter of photosensitiveness.
Warm color-change powder is a kind of microcapsules changing color with temperature rise or decline, is organised by electron transfer type
Close prepared by objects system.Electron transfer type organic compound is a kind of organic chromophoric system with special chemical structure.In spy
Determine because electronics transfer makes the molecular structure of the organic matter change at temperature, to realize color change.The test model of temperature
It is 0 DEG C~45 DEG C to enclose, and temperature is revealed as colorless state at test environment≤32 DEG C, when 32 DEG C of >, is revealed as pink colour state.
The test scope 30%RH-90%RH of humidity, the i.e. chromogenic reaction of humidity can with the increase of humidity, color from depth to shallow, most
After become colorless.Humiture identifies that judgment method is intuitive, is easy observation, also brings facility to the use of operator.
Description of the drawings
Fig. 1 is a kind of structural schematic diagram of embodiment of poct diagnostic reagents carrier of the present invention.
Specific implementation mode
Specific introduce is made to the present invention below in conjunction with the drawings and specific embodiments.
A kind of environmental detection set suitable for poct class diagnostic reagents, including：It is fixed on poct class diagnostic reagent carriers
On temperature colour developing item and humidity chromogenic item.It should be noted that can there was only temperature colour developing item or temperature colour developing on carrier
Item one of them, and develop the color item number be not limited.
Temperature colour developing item is formed by temperature chromogenic reaction slurry；Temperature chromogenic reaction slurry is formed according to mass percent
Have：The solvent of 57-63%, the resin of 27-33%, the surfactant of 0.3%-0.9%, the temperature-sensitive toner of 7%-13%；Sense
Warm colour powder is prepared by Reversible Thermochromic Compounds by electronics transfer.
Humidity chromogenic item is formed by humidity chromogenic reaction paste；Humidity chromogenic reaction paste is formed according to mass percent
Have：The solvent of 57-63%, the resin of 27-33%, the surfactant of 0.3%-0.9%, the wet toner of sense of 7%-13%.Sense
Wet toner, which is placed in by colorant in silicon substrate carrier, to be prepared.
A kind of manufacturing method of environmental detection set suitable for poct class diagnostic reagents, including：
Configure temperature chromogenic reaction slurry；Temperature colour developing item is formed by temperature chromogenic reaction slurry；Temperature chromogenic reaction is starched
Material has according to mass percent composition：The solvent of 57-63%, the resin of 27-33%, the surfactant of 0.3%-0.9%,
The temperature-sensitive toner of 7%-13%；Temperature-sensitive toner is prepared by Reversible Thermochromic Compounds by electronics transfer；By solvent, tree
Fat, surfactant, temperature-sensitive toner are in uniform flow-like according to proportioning successively uniform dissolution.
As a kind of embodiment, solvent can select methanol, DMF, ethylene glycol diethyl ether, toluene, cyclohexanone, benzyl alcohol,
One or more combinations in dimethylbenzene, hexamethylene.
As a kind of embodiment, resin uses the resin of high solids low-viscosity (low polymerization degree or low molecular weight), can be with
Select epoxy resin, phenolic resin, Lauxite, melamine resin, furane resins, organic siliconresin, polyester resin,
One kind in polyamide, acrylic resin, polyurethane, vinylite, hydrocarbon resins, polyethers resinoid, vinyl chloride-vinyl acetate resin
Or multiple combinations.
As a kind of embodiment, surfactant is polyether-modified organosilicon, ethylene oxide adduct and fluoropolymer
The fatty acid ester compounded object of object, silicone emulsion, higher alcohols, polyoxyethylene polyoxypropylene pentaerythrite ether, polyoxyethylene polyoxy propyl alcohol
One or more combinations in amidogen ether, polypropylene glycerol aether and polyoxypropylene.
As a kind of embodiment, temperature-sensitive toner is prepared by Reversible Thermochromic Compounds by electronics transfer；It can backheating
Color compound includes：Loop coil class Reversible Thermochromic Compounds, the Reversible Thermochromic Compounds of more aromatic rings containing CH=CH,
One or more combinations of Schiff Reversible Thermochromic Compounds.
Configure humidity chromogenic reaction paste；Humidity chromogenic item is formed by humidity chromogenic reaction paste；Humidity chromogenic reaction slurry
Material has according to mass percent composition：The solvent of 57-63%, the resin of 27-33%, the surfactant of 0.3%-0.9%,
The wet toner of sense of 7%-13%；Feel wet toner and be placed in silicon substrate carrier by colorant and is prepared；By solvent, resin, surface is lived
Property agent, feel wet toner according to proportioning uniform dissolution successively, be in uniform flow-like.
As a kind of embodiment, solvent can select methanol, DMF, ethylene glycol diethyl ether, toluene, cyclohexanone, benzyl alcohol,
One or more combinations in dimethylbenzene, hexamethylene.
As a kind of embodiment, resin uses the resin of high solids low-viscosity (low polymerization degree or low molecular weight), can be with
Select epoxy resin, phenolic resin, Lauxite, melamine resin, furane resins, organic siliconresin, polyester resin,
One kind in polyamide, acrylic resin, polyurethane, vinylite, hydrocarbon resins, polyethers resinoid, vinyl chloride-vinyl acetate resin
Or multiple combinations.
As a kind of embodiment, surfactant is polyether-modified organosilicon, ethylene oxide adduct and fluoropolymer
The fatty acid ester compounded object of object, silicone emulsion, higher alcohols, polyoxyethylene polyoxypropylene pentaerythrite ether, polyoxyethylene polyoxy propyl alcohol
One or more combinations in amidogen ether, polypropylene glycerol aether and polyoxypropylene.
Feel wet toner and be placed in silicon substrate carrier by colorant and is prepared；As a kind of embodiment, colorant can be iron
(II) and/or activated indicators as iron (III) salt or salt can also be, acid-base indicator；As a kind of embodiment, acid
Neutralization indicator includes：One or more combinations in reindeer moss, crystal violet, Bromothymol blue, xylenol basket.Colorant with
Water combines, and color changes.
Temperature chromogenic reaction slurry, humidity chromogenic reaction paste are printed on the diagnosis examination of poct classes by screen printing technique
On the carrier of agent；Screen printing technique is using film thickness 20um, 300 mesh of mesh number, 22.5 ° of angle, the silk-screen of 21 ± 1N of tension
Halftone.
Before silk-screen printing, need to adjust screen printer print parameter；Specific silk-screen parameter is as follows：Screen printer air pressure should be
Within the scope of 6.0 ± 1.0Bar；It is required that silk-screen figure is in scraper center and, the angle of scraper and halftone parallel with scraper：
75°；The speed of service：240mm/s±100mm/s；The gap of ink-retruning blade and halftone screen cloth is about the thickness of an A4 paper, to be protected
Hold appropriate carbon slurry thickness uniform fold whole silk-screen graphics field；The speed of service：240mm/s±100mm/s；Between table top halftone
Away from：4.0mm±1.0mm；And examination printing is carried out after being aligned to silk-screen halftone.Under process above printing parameter, test strips
Performance it is best, desired use of otherwise arriving.
Carrier after printing is placed in baker and cured, dried.As a kind of embodiment, baker uses IR
Drying line, drying, solidification design parameter are as follows：Spin manifold temperature is set as 110 DEG C, and the temperature in oven body is made to control at 110 DEG C
±2℃。
Transmission net tape speed：Ensure that by the time for keeping the temperature effective coverage be 6 ± 1min；Corresponding guipure speed is 0.8
M/min.Under process above printing parameter, the performance of test strips is best, desired use of otherwise arriving.
Upper cover plate after drying sticks in the top of test paper.
The principle of colour developing；Warm color-change powder is a kind of microcapsules changing color with temperature rise or decline, is by electronics
Prepared by transfevent organic compound objects system.Electron transfer type organic compound is a kind of organic hair with special chemical structure
Color system.At a certain temperature because electronics transfer makes the molecular structure of the organic matter change, to realize color change.Sense
Colorant in wet toner can be combined with water, and color changes.Humiture identifies that judgment method is intuitive, is easy observation, also gives
The use of operator brings facility.
User by poct class diagnostic reagents expose under the test environment, the carrier part of poct class diagnostic reagents it is corresponding
Printing part can participate in temperature chromogenic reaction, humidity chromogenic reaction, judge whether the environment meets test request by color.
The test scope of temperature is 0 DEG C~45 DEG C, and for temperature at test environment≤32 DEG C, the coloured moiety of silk-screen printing is colourless, >
At 32 DEG C, the part of silk-screen printing can show pink colour.The test scope 30%RH-90%RH of humidity, the i.e. chromogenic reaction of humidity
It from depth to shallow, can be eventually become colourless with the increase of humidity, color.
If user uses poct class diagnostic reagents, the temperature identification point pink colour on poct class diagnostic reagent carrier parts,
Or the color of the humidity identification point on poct class diagnostic reagent carrier parts is light green color；Then the environment does not meet test and wants
It asks.
In order to verify the present invention temperature chromogenic reaction slurry, humidity chromogenic reaction paste can be real in ratio range
It now detects, does following experiment：
Experiment one：
Temperature chromogenic reaction slurry：Solvent uses：DMF, resin use epoxy resin：Surfactant uses polyoxyethylene
Polyoxy propyl alcohol amidogen ether：Temperature-sensitive toner is generated by loop coil class Reversible Thermochromic Compounds in electronics transfer chemical reaction system.
Configure temperature chromogenic reaction slurry；Temperature colour developing item is formed by temperature chromogenic reaction slurry；Temperature chromogenic reaction is starched
Material has according to mass percent composition：The solvent of 57-63%, the resin of 27-33%, the surfactant of 0.3%-0.9%,
The temperature-sensitive toner of 7%-13%；
Embodiment 1,57g solvents, 33g resins, 0.3g surfactants, 9.7g temperature-sensitive toners；
Embodiment 2,63g solvents, 27g resins, 0.9g surfactants, 9.1g temperature-sensitive toners；
Embodiment 2,58g solvents, 28.3g resins, 0.7g surfactants, 13g temperature-sensitive toners；
It by same set of technique, is printed on carrier, is individually positioned in 26 DEG C, 32 DEG C, in 36 DEG C of vial, colour developing is such as
Under：
By being tested above it is found that the ratio range according to formula configures, obtained colour developing item all has detectability.
Experiment two：
Humidity chromogenic reaction paste：Solvent uses：DMF, resin use epoxy resin：Surfactant uses polyoxyethylene
Polyoxy propyl alcohol amidogen ether：Feel wet toner to be made up of iron (II) salt dipping silicon substrate carrier.
Configure humidity chromogenic reaction paste；Humidity chromogenic item is formed by humidity chromogenic reaction paste；Humidity chromogenic reaction slurry
Material has according to mass percent composition：The solvent of 57-63%, the resin of 27-33%, the surfactant of 0.3%-0.9%,
The wet toner of sense of 7%-13%；
Embodiment 1,57g solvents, 33g resins, 0.3g surfactants, 9.7g feel wet toner；
Embodiment 2,63g solvents, 27g resins, 0.9g surfactants, 9.1g feel wet toner；
Embodiment 2,58g solvents, 28.3g resins, 0.7g surfactants, 13g feel wet toner；
It by same set of technique, is printed on carrier, it is 30%RH, the glass of 60%RH, 90%RH to be individually positioned in humidity
In glass bottle, colour developing is as follows：
By being tested above it is found that the ratio range according to formula configures, obtained colour developing item all has detectability.
The present invention provides a kind of environmental detection set and its manufacturing method suitable for poct class diagnostic reagents, in poct classes
Temperature and Humidity item is set on diagnostic reagent carrier, convenient for users to voluntarily judging poct classes diagnostic reagents environment when in use
Whether humiture meets product technology requirement；Humiture identification point is simple in structure, and judgment method is intuitive, is easy observation, also gives
The use of operator brings facility.
The basic principles, main features and advantages of the invention have been shown and described above.The technical staff of the industry should
Understand, the invention is not limited in any way above-described embodiment, all to be obtained by the way of equivalent substitution or equivalent transformation
Technical solution is all fallen in protection scope of the present invention.
Claims (10)
1. a kind of environmental detection set suitable for poct class diagnostic reagents, which is characterized in that including：It is fixed on the diagnosis of poct classes
Temperature colour developing item on reagent carrier.
2. a kind of environmental detection set suitable for poct class diagnostic reagents according to claim 1, which is characterized in that institute
Temperature colour developing item is stated to be formed by temperature chromogenic reaction slurry；The temperature chromogenic reaction slurry has according to mass percent composition：
The solvent of 57%-63%, the resin of 27%-33%, the surfactant of 0.3%-0.9%, the temperature-sensitive toner of 7%-13%；Institute
Temperature-sensitive toner is stated to be prepared by electronics transfer by Reversible Thermochromic Compounds.
3. a kind of environmental detection set suitable for poct class diagnostic reagents, which is characterized in that including：It is fixed on the diagnosis of poct classes
Humidity chromogenic item on reagent carrier.
4. a kind of environmental detection set suitable for poct class diagnostic reagents according to claim 3, which is characterized in that institute
Humidity chromogenic item is stated to be formed by humidity chromogenic reaction paste；The humidity chromogenic reaction paste has according to mass percent composition：
The solvent of 57%-63%, the resin of 27%-33%, the surfactant of 0.3%-0.9%, the wet toner of sense of 7%-13%；Institute
It states the wet toner of sense and is placed in silicon substrate carrier by colorant and is prepared.
5. a kind of environmental detection set suitable for poct class diagnostic reagents, which is characterized in that including：It is fixed on the diagnosis of poct classes
Temperature colour developing item on reagent carrier and humidity chromogenic item.
6. a kind of environmental detection set suitable for poct class diagnostic reagents according to claim 5, which is characterized in that
The temperature colour developing item is formed by temperature chromogenic reaction slurry；The temperature chromogenic reaction slurry is according to mass percent group
Cheng You：The solvent of 57-63%, the resin of 27-33%, the surfactant of 0.3%-0.9%, the temperature-sensitive toner of 7%-13%；
The temperature-sensitive toner is prepared by Reversible Thermochromic Compounds by electronics transfer；
The humidity chromogenic item is formed by humidity chromogenic reaction paste；The humidity chromogenic reaction paste is according to mass percent group
Cheng You：The solvent of 57-63%, the resin of 27-33%, the surfactant of 0.3%-0.9%, the wet toner of sense of 7%-13%；
The wet toner of sense, which is placed in by colorant in silicon substrate carrier, to be prepared.
7. a kind of manufacturing method of environmental detection set suitable for poct class diagnostic reagents, which is characterized in that including：
Configure temperature chromogenic reaction slurry；The temperature colour developing item is formed by temperature chromogenic reaction slurry；The temperature colour developing is anti-
Slurry is answered to have according to mass percent composition：The solvent of 57-63%, the resin of 27-33%, the surface-active of 0.3%-0.9%
Agent, the temperature-sensitive toner of 7%-13%；The temperature-sensitive toner is prepared by Reversible Thermochromic Compounds by electronics transfer；It will be molten
Agent, resin, surfactant, temperature-sensitive toner are in uniform flow-like according to proportioning successively uniform dissolution；
Configure humidity chromogenic reaction paste；The humidity chromogenic item is formed by humidity chromogenic reaction paste；The humidity chromogenic is anti-
Slurry is answered to have according to mass percent composition：The solvent of 57-63%, the resin of 27-33%, the surface-active of 0.3%-0.9%
Agent, the wet toner of sense of 7%-13%；The wet toner of sense, which is placed in by colorant in silicon substrate carrier, to be prepared；By solvent, resin,
Surfactant feels wet toner according to proportioning successively uniform dissolution, is in uniform flow-like；
The temperature chromogenic reaction slurry, humidity chromogenic reaction paste are printed on the diagnosis examination of poct classes by screen printing technique
On the carrier of agent；
Carrier after printing is placed in baker and cured, dried.
8. a kind of manufacturing method of environmental detection set suitable for poct class diagnostic reagents according to claim 7,
It is characterized in that,
The screen printing technique is using film thickness 20um, 300 mesh of mesh number, 22.5 ° of angle, the silk printing screen of 21 ± 1N of tension
Version.
9. a kind of manufacturing method of environmental detection set suitable for poct class diagnostic reagents according to claim 7,
It is characterized in that, before silk-screen printing, needs to adjust screen printer print parameter；
Specific silk-screen parameter is as follows：Screen printer air pressure should be within the scope of 6.0 ± 1.0Bar；It is required that silk-screen figure is in scraper center
And, the angle of scraper and halftone parallel with scraper：75°；The speed of service：240mm/s±100mm/s；The operation speed of ink-retruning blade
Degree：240mm/s±100mm/s；Table top halftone spacing：4.0mm±1.0mm.
10. a kind of manufacturing method of environmental detection set suitable for poct class diagnostic reagents according to claim 7,
It is characterized in that, the baker uses IR drying lines, drying, solidification design parameter as follows：
Spin manifold temperature is set as 110 DEG C, and the temperature in oven body is made to control at 110 DEG C ± 2 DEG C；
Transmission net tape speed：Ensure that by the time for keeping the temperature effective coverage be 6 ± 1min；Corresponding guipure speed is 0.8 m/min
Clock.
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| JP2012127885A (en) * | 2010-12-17 | 2012-07-05 | Kyodo Printing Co Ltd | Humidity indicator and method for manufacturing the same |
| CN103814293A (en) * | 2011-09-12 | 2014-05-21 | 金伯利-克拉克环球有限公司 | Wetness indicator having varied hues |
| CN104875544A (en) * | 2014-02-27 | 2015-09-02 | 金红叶纸业集团有限公司 | Color development material and preparation method |
| CN105038410A (en) * | 2015-09-15 | 2015-11-11 | 东莞市润丽华实业有限公司 | Anti-counterfeiting and temperature-changing printing ink |
| CN105131717A (en) * | 2015-09-10 | 2015-12-09 | 上海贝达包装材料有限公司 | Environment-friendly color-changeable printing ink with humidity display function and preparation method of printing ink |
| CN105572110A (en) * | 2014-11-04 | 2016-05-11 | 三星电子株式会社 | A method of and an apparatus for measuring biometric information |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1281144A (en) * | 2000-03-24 | 2001-01-24 | 青岛海洋化工有限公司 | Multi-colour allochromatic indicator and its producing method |
| JP2012127885A (en) * | 2010-12-17 | 2012-07-05 | Kyodo Printing Co Ltd | Humidity indicator and method for manufacturing the same |
| CN103814293A (en) * | 2011-09-12 | 2014-05-21 | 金伯利-克拉克环球有限公司 | Wetness indicator having varied hues |
| CN104875544A (en) * | 2014-02-27 | 2015-09-02 | 金红叶纸业集团有限公司 | Color development material and preparation method |
| CN105572110A (en) * | 2014-11-04 | 2016-05-11 | 三星电子株式会社 | A method of and an apparatus for measuring biometric information |
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