CN108785363A

CN108785363A - Application of the yellow wingceltis platymiscium perfume (or spice) material in the drug for preparing treatment microorganism infection

Info

Publication number: CN108785363A
Application number: CN201811029360.9A
Authority: CN
Inventors: 王祥红
Original assignee: Zhuhai Ou Pu Si Household Products Co Ltd
Current assignee: Zhuhai Ou Pu Si Household Products Co Ltd
Priority date: 2018-09-05
Filing date: 2018-09-05
Publication date: 2018-11-13

Abstract

The invention discloses application of the yellow wingceltis platymiscium perfume (or spice) material in the drug for preparing treatment microorganism infection.When yellow wingceltis platymiscium is grown to a certain degree, stem center starts to assemble the ingredients such as volatile oil, flavones, tannin so that darkens, density becomes larger, forms heartwood shape perfume (or spice) material.Or to be chopped wound by artificially, after worm ant is bitten or typhoon blows wound, the surface of a wound is gathered in for some special compositions secreted by protection wound, make the surface of a wound darken, density becomes larger, and can also form fragrant material.This perfume material is applied alone or is used cooperatively with ethyl alcohol, or with other medicines compatibility, or the uses such as powder, tablet, tincture, vina, spray are made, or it is used in mixed way with facial mask, toothpaste, perfumed soap, handmade soap, it can play the role for the treatment of a variety of diseases such as canker sore, tinea pedis, diabetes, the acne of microorganism infection, to the Small side effects of human body, therapeutic effect is apparent.

Description

Application of the yellow wingceltis platymiscium perfume (or spice) material in the drug for preparing treatment microorganism infection

Technical field

The present invention relates to application of the yellow wingceltis platymiscium perfume (or spice) material in the drug for preparing treatment microorganism infection.

Background technology

One of microorganism influence most important on the mankind is exactly the prevalence for leading to infectious disease.Microorganism mainly include bacterium, Fungi, virus, Chlamydia, mycoplasma etc., and having 50% in human diseases is caused by virus.Microorganism leads to human diseases The history that history and the mankind constantly struggle against therewith.

By the research of Antimicrobial agent for many years, the mankind make some progress in the struggle with microorganism.

In terms of antibacterial medicament, since penicillin is found, modern medicinal agents develop very soon in terms of to antibacterium, Not lower hundred kinds so far, but also encounter huge challenge at present.Environmental pollution caused by abuse of antibiotics, bacterium are resistance to Medical increases the generation of even superbacteria, causes new antibiotic variety development difficulty increasing, and antibiotics The speed of exploitation is far unable to catch up with bacterial dissociation and drug resistant speed, and doctor can be absorbed in very much the available awkward situation of antibiotic-free.

In the treatment of the microorganism infections such as Chlamydia, mycoplasma, the drug that can be treated is relatively fewer, in predominantly big ring Esters antibiotic.

In the treatment of fungal infection, main drug is machine acids, polyenoid class, nitrogen azole, propylamine etc., but these On the one hand drug is easier to generate drug resistance, in addition side effect is also bigger.

And to human health risk it is maximum virus on, current antiviral drugs is even more limited, even common Common cold virus can not make its drug being completely recovered yet.

In the research of Chinese medicine Antimicrobial agent, many antipyretic and antidotal type Chinese medicines have antiviral, antibacterium, Zhi Yuan The effects that body, Chlamydia or fungi, such as radix scutellariae, the coptis, Herba Andrographitis etc., all have the work of different degrees of anti-sex pheromone With, and cacumen biotae, the tuber of stemona, Golden Larch Bark etc. have certain antifungic action, these Chinese medicines have certain advantage, but study base Plinth is less, using little.

The application study of yellow wingceltis platymiscium in medicine is concentrated mainly on sissoo (Dalbergia sissoo), dalbergia wood On yellow wingceltis (Dalbergia odorifera), broad-leaved yellow wingceltis (Dalbergia latifoliaRoxb) several species.And mostly Number has only included root, stem or leaf etc. and has been used as medicine, and effect is also only in terms of qi-regulating, promoting blood circulation, analgesic.And the platymiscium perfume (or spice) material disappears in antibacterial The effect of scorching aspect, has no record.

Invention content

The object of the present invention is to provide a kind of new application of yellow wingceltis platymiscium perfume (or spice) material, i.e. yellow wingceltis platymiscium perfume (or spice) material is controlled in preparation Treat the application in the drug of microorganism infection.

To achieve the goals above, the present invention provides a kind of yellow wingceltis platymiscium perfume (or spice) material in the medicine for preparing treatment microorganism infection Application in object.

One specific scheme is that it is yellow that the yellow wingceltis platymiscium perfume (or spice) material is selected from Lignum Dalbergiae benthamii perfume (or spice) material, Burma's yellow wingceltis perfume (or spice) material, curved branch Santal material, king kong rattan perfume (or spice) material, gamboge santal material, Mengzi yellow wingceltis perfume (or spice) material, Hong Kong yellow wingceltis perfume (or spice) material, trunk rattan perfume (or spice) material, white sand yellow wingceltis Fragrant material, Many-cleft Rosewood perfume (or spice) material, narrow leaf yellow wingceltis perfume (or spice) material, stipule yellow wingceltis perfume (or spice) material, red fruit yellow wingceltis perfume (or spice) material, Yunnan Guizhou Province yellow wingceltis perfume (or spice) material, suede leaf are yellow Santal material, the southern regions of the Yunnan Province yellow wingceltis perfume (or spice) material, oblique leaf yellow wingceltis perfume (or spice) material, South Asia yellow wingceltis perfume (or spice) material, yellow wingceltis perfume (or spice) material, Ai Baidisi yellow wingceltis perfume (or spice) material, thorn are yellow Santal material, Luigi Beccali yellow wingceltis perfume (or spice) material, the people all Shandong yellow wingceltis perfume (or spice) material, Borneo's yellow wingceltis perfume (or spice) material, Clarke yellow wingceltis perfume (or spice) material, close colored yellow wingceltis are fragrant It is material, cuneus yellow wingceltis perfume (or spice) material, Coromandel yellow wingceltis perfume (or spice) material, Kui Ming yellow wingceltis perfume (or spice) material, Ke Disi yellow wingceltis perfume (or spice) material, close hair yellow wingceltis perfume (or spice) material, different Color yellow wingceltis perfume (or spice) material, coin rattan perfume (or spice) Cai, Ke vine leaf yellow wingceltis perfume (or spice) material, sickle fruit yellow wingceltis perfume (or spice) material, rust yellow wingceltis perfume (or spice) material, recessed leaf yellow wingceltis are fragrant Material, Forbes yellow wingceltis perfume (or spice) material, Gardner's yellow wingceltis perfume (or spice) material, Ge Shi yellow wingceltis perfume (or spice) material, thorniness yellow wingceltis perfume (or spice) material, sky this yellow wingceltis perfume (or spice) material, Hu Lai Special yellow wingceltis perfume (or spice) material, Johore's yellow wingceltis perfume (or spice) material, holds big vast yellow wingceltis perfume (or spice) material, library this Teller yellow wingceltis perfume (or spice) material, Maraba yellow wingceltis at Ya Er yellow wingceltis perfume (or spice) material Fragrant material, moon fruit yellow wingceltis perfume (or spice) material, little Hua yellow wingceltis perfume (or spice) material, Pi Natubo yellow wingceltis perfume (or spice) material, leafy yellow wingceltis perfume (or spice) material, leather leaf yellow wingceltis perfume (or spice) material, net Arteries and veins yellow wingceltis perfume (or spice) material, Richards's yellow wingceltis perfume (or spice) material, rust reddish yellow santal material, Sandakan yellow wingceltis perfume (or spice) material, this Cole's Gabriele Tarquini yellow wingceltis perfume (or spice) material, length It is fragrant to pierce yellow wingceltis perfume (or spice) material, smelly yellow wingceltis perfume (or spice) material, blueness yellow wingceltis perfume (or spice) material advanced in years, Te Siman yellow wingceltis perfume (or spice) material, Thomson yellow wingceltis perfume (or spice) material, support labor yellow wingceltis It is one or more in material, Ting Nifuli yellow wingceltis perfume (or spice) materials or Annan's yellow wingceltis perfume (or spice) material.

Another specific scheme is that the microorganism infection is fungal infection.

Another specific scheme is that the microorganism infection is bacterium infection.

Another specific scheme is that the microorganism infection is viral infection.

Another specific scheme is that the microorganism infection is specially the pruitus of microorganism infection, microorganism infection Tinea pedis, the onychomycosis of microorganism infection, the jock itch of microorganism infection, the canker sore of microorganism infection, microorganism infection The vinasse nose of acne, the diabetes of microorganism infection or microorganism infection.

Another specific scheme is that the yellow wingceltis platymiscium perfume (or spice) material is in use, the yellow wingceltis platymiscium perfume (or spice) material is ground into Powder is extracted yellow wingceltis platymiscium perfume (or spice) material by suitable solvent, then by detaching, refining, concentrate and drying process system Obtain the yellow wingceltis platymiscium perfume (or spice) material extract.

Another specific scheme is, the yellow wingceltis platymiscium perfume (or spice) material is in use, pass through steam distillation or overcritical The yellow wingceltis platymiscium perfume (or spice) material essential oil is obtained by extraction in flow process.

Another specific scheme is, the yellow wingceltis platymiscium perfume (or spice) material in use, the yellow wingceltis platymiscium perfume (or spice) material can with Asian puccoon, One or more carry out compatible uses in Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, dragon's blood, dye yam, clam, ginseng, borneol, agalloch eaglewood, santal.

Another specific scheme is, the yellow wingceltis platymiscium perfume (or spice) material in use, by the yellow wingceltis platymiscium perfume (or spice) material with it is medical Antiseptic solution is used cooperatively.The medical disinfecting solution includes alcohol, hydrogen peroxide, the tincture of iodine, potassium permanganate, glutaraldehyde, Iodophor etc..

The present invention using yellow wingceltis platymiscium perfume (or spice) material as treatment microorganism infection in terms of drug, such plant perfume (or spice) material is natural Complex compound, compared to currently used antimicrobial agents Small side effects, in terms for the treatment of microorganism infection the effect of, is bright It is aobvious.

Description of the drawings

Fig. 1 is the effect of the embodiment of the invention by the little Hua yellow wingceltis perfume (or spice) timber-useds in yellow wingceltis platymiscium perfume (or spice) material in treatment tinea pedis Comparison diagram.Wherein, Fig. 1 (a) is the state diagram that patient is not used before little Hua yellow wingceltis perfume (or spice) materials.Fig. 1 (b) is that patient uses little Hua yellow wingceltises State diagram after fragrant material treatment.

Fig. 2 is the effect of the embodiment of the invention by the red fruit yellow wingceltis perfume (or spice) timber-used in yellow wingceltis platymiscium perfume (or spice) material in treatment vinasse nose Fruit comparison diagram.Wherein, Fig. 2 (a) is the state diagram that patient is not used before red fruit yellow wingceltis perfume (or spice) material.Fig. 2 (b) is that patient is yellow using red fruit State diagram after the treatment of santal material.

Fig. 3 be the present invention by the Lignum Dalbergiae benthamii perfume (or spice) timber-used in yellow wingceltis platymiscium perfume (or spice) material in treatment diabetes embodiment Effect contrast figure.Wherein, Fig. 3 (a) is the state diagram that patient is not used before Lignum Dalbergiae benthamii perfume (or spice) material.Fig. 3 (b) is that patient uses two Guangdong The state diagram of yellow wingceltis perfume (or spice) material after one week treatment.Fig. 3 (c) is the state diagram after patient is treated one month using Lignum Dalbergiae benthamii perfume (or spice) material.

The invention will be further described with reference to the accompanying drawings and embodiments.

Specific implementation mode

With reference to specific embodiment to yellow wingceltis platymiscium perfume (or spice) material of the present invention prepare treatment microorganism infection drug in Application be described in detail.

The yellow wingceltis platymiscium it is long to a certain extent when, stem center start to assemble volatile oil, flavones, tannin etc. at Point so that the darkening of stem center, density becomes larger, and then forms heartwood shape perfume (or spice) material.Or when the yellow wingceltis platymiscium is by people To chop wound, worm ant bites or after typhoon blows wound, is gathered in the surface of a wound for some special compositions secreted by protection wound so that the surface of a wound It darkens, density becomes larger, and can also form fragrant material.

The fragrant material of yellow wingceltis platymiscium has special fragrance since its color is red, aubergine, yellow or black etc., There is a small amount of raw material or fragrance as craftworks such as hand strings at present.Document, which records this kind of fragrant material, has preferable hemostasia and promoting granulation, work The effects that the effect of blood stagnation resolvation, external application can be to wound hemostasis, promotion wound healing.Present invention discover that the perfume (or spice) of above-mentioned yellow wingceltis platymiscium Material also has the function of that excellent treatment microorganism infection, this treatment microorganism infection effect include treatment bacterium infection, control Virus infection, treatment fungal infection, treatment are treated according to many aspects such as pathogen infection, treatment mycoplasma infections.

The fragrant material of above-mentioned yellow wingceltis platymiscium when in use, can be processed into powder, can also be by steam distillation or use Supercritical fluid method extraction is made essential oil or extract is made with suitable solvent or is further processed into monomeric compound, is applied alone Or with other medicines compatible use, or powder, tablet, tincture, vina or spray is made etc. and uses or be made facial mask, toothpaste, The special household chemicals such as perfumed soap, handmade soap uses.

The step of essential oil of such plant perfume (or spice) material (by taking Lignum Dalbergiae benthamii as an example) is obtained by extraction by steam distillation is as follows：

(1) Lignum Dalbergiae benthamii perfume (or spice) material is crushed to 10 to 50 mesh, obtains Lignum Dalbergiae benthamii perfume (or spice) material powder；

(2) Lignum Dalbergiae benthamii perfume (or spice) material powder 100g accurately is weighed, be put into the round-bottomed flask of 2000mL；

(3) it presses volume mass and is impregnated under room temperature after shaking mixing than the distilled water and bead number of 10 times of amounts is added 60min connects volatile oil extractor and reflux condensing tube；

(4) autocondensation pipe upper end Jia Shui makes it be full of scale part of volatile oil extractor, and when overflow enters flask until. It sets in electric jacket or is slowly heated to boiling with other proper methods, and keep slightly boiling about 10h, until oil mass no longer increases in extractor Add, stop heating, place a moment, Lignum Dalbergiae benthamii perfume (or spice) material volatile oil part is collected in volatile oil extractor lower end；

(5) suitable anhydrous Na is slowly added into volatile oil₂SO₄, remove Na₂SO₄, obtain the essence of Lignum Dalbergiae benthamii perfume (or spice) material Oil.

The step of such plant perfume (or spice) material (by taking little Hua yellow wingceltises as an example) essential oil is obtained by extraction by supercritical fluid method is as follows：

(1) little Hua yellow wingceltis perfume (or spice) materials are crushed to 10 to 50 mesh, obtain little Hua yellow wingceltis perfume (or spice) material powder；

(2) supercritical extracting equipment power supply is connected, SAPMAC method and switch heating is opened, sets extraction kettle temperature as 50 DEG C, Separation reactor I temperature is 35 DEG C, and separation reactor I I temperature is 35 DEG C, CO₂Flow is 25L/h；

(3) little Hua yellow wingceltis perfume (or spice) material powder 100g accurately are weighed, put into extraction kettle, start CO₂The circulatory system adjusts extraction It is 30MPa to take kettle pressure, and separation reactor I pressure is 5MPa, and separation reactor I I pressure is 5MPa；

(4) using absolute ethyl alcohol as entrainer, dosage is the 50% of feeding quantity；

(5) when kettle to be extracted, the temperature of separation reactor I and separation reactor I I and pressure reach the setting value, when start recording Between, wherein extraction time is 3h；

(6) after extracting, gained liquid, as little Hua yellow wingceltises perfume (or spice) material essential oil are released from separation reactor I and separation reactor I I.

The fragrant material of yellow wingceltis platymiscium can be with works such as water (containing pH is adjusted), ethyl alcohol, methanol, ethyl acetate, petroleum ether or gasoline For Extraction solvent, the fragrant material constituents extraction of yellow wingceltis platymiscium is come out, then is made by the techniques such as detaching, refining, concentrate, dry Extract or monomeric compound.

Theory of traditional Chinese medical science is relied primarily in terms of the fragrant material compatibility of above-mentioned yellow wingceltis platymiscium, according to its property, taste, effect, function master Control etc. and to carry out dialectical treatmert, common compatibility drug have Asian puccoon, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, dragon's blood, dye yam, clam, ginseng, borneol, agalloch eaglewood, Santal etc..

The example that yellow wingceltis perfume (or spice) material is made to household chemicals is as follows：

Improve zicao soft plaster：Zicao soft plaster is containing the drugs such as Asian puccoon, dragon's blood, Radix Angelicae Sinensis, Radix Astragali composition, to a variety of skins such as wound, eczema Skin disease has good effect, takes commercially available zicao soft plaster (Kunming Quanxin Biological Pharmaceutical Co., Ltd.'s production) box, and it is super that Lignum Dalbergiae benthamii perfume (or spice) material is added Fine powder 0.3g or considerable amount of extracts, grind well, and obtain improvement zicao soft plaster, through test of many times, to scald, bite by mosquitos, Acne and eczema etc. has more preferable curative effect.

The effect of yellow wingceltis platymiscium perfume (or spice) material in treating microorganism infection to illustrate the invention below, is spread using filter paper Method studies the antibacterial activity of yellow wingceltis platymiscium perfume (or spice) material.

The type for the yellow wingceltis platymiscium that 1.1 experiments use is as shown in the table：

1.2 for trying strain

Escherichia coli Escheichia coli

Staphylococcus aureus Stapnylocouusaureccs

Bacillus subtilis Bacillus subtilis

The above strain is all purchased from disease prevention and control center of Hunan Province.

1.3 reagent

Beef extract, peptone, agar glucose, sodium chloride, oxychloride sodium, sulfuric acid, barium chloride (being that analysis is pure)；Ma Ling Potato：It is commercially available.

Positive control：Tetracycline.

1.4 key instruments and equipment

Oxford cup

THZ-103B constant-temperature shaking incubators Shanghai Yiheng Scientific Instruments Co., Ltd

LS-35LD type high-pressure sterilizing pots Jiangyin Binjiang Medical Equipment Co., Ltd.

LRH-150F type biochemical cultivation cases Shanghai Yiheng Scientific Instruments Co., Ltd

SW-CJ-1F type superclean benches Shanghai rich news medical bio-instruments limited liability company

2 experimental methods

The preparation of 2.1 culture mediums

Beef extract albumen agar medium preparation formula：Beef extract 3g, peptone 10g, agar glucose 20g, sodium chloride 5g, water 1000mL, pH value 7.2-7.4.It is weighed up among reagent is put into beaker by the formula, adds water to 1000mL, boiled on electric furnace It to slightly boiling, during which ceaselessly stirs, each component in culture medium is made to dissolve, boiling after five minutes, then is settled to 1000mL, adjusts pH value 7.2-7.4, turns to be attached in triangular flask, mouth is sealed with tampon and ox-hide paper wrapper, and at 121 DEG C, progress high pressure sterilization 20min, standby With.

It is prepared by 2.2 culture medium plates

After prepared beef extract albumen agar medium high pressure steam sterilization, it is cooled to 50-60 DEG C, in ultra-clean work Culture medium is poured under platform and aseptic technique in the sterile petri dish after high pressure sterilization, per ware 10-15mL, is leveled to training Base solidification is supported, it is spare.

The activation of 2.3 strains

One oese is respectively connected to Escherichia coli, staphylococcus aureus, bacillus subtilis equipped with beef extract egg In the slant tube of white agar medium 4mL, 37 DEG C are cultivated for 24 hours, for use.

The preparation of 2.4 bacteria suspensions

Using inclined-plane low temperature preservation preservation of bacteria strain.Picking proper amount of strains, is coated on culture medium, 37 DEG C culture for 24 hours, from One ring thalline of picking is inoculated in corresponding fluid nutrient medium on thalline tablet through overactivation, is put into constant-temperature shaking incubator, To exponential phase, (cell metabolism of exponential phase is most vigorous, very sensitive to outside environmental elements, therefore is used as antibacterial for culture Experiment).Then it draws respectively for trying bacterium solution 0.5mL, sterile water is added, doubling dilution to 105-106CFU/mL is spare.

The measurement of 2.5 fungistatic effects

Above-mentioned yellow wingceltis platymiscium perfume (or spice) material 10g that is dry, crushing is weighed, water 100ml, boiling water bath 60 minutes is added to subtract after filtering It pushes back and receives to obtain medicinal extract.Each yellow wingceltis platymiscium perfume (or spice) material medicinal extract is made into the solution of 10mL with sterile water, with 0.22 μm of aseptic filtration Membrane filtration converts into a concentration of 1.0g/mL of perfume material weight.Qualitative filter paper is made the roundlet scraps of paper with card punch, a diameter of 6mm, It is spare to be put into hot air sterilization 120min in plate.On superclean bench, culture medium is poured into tablet, about 1.5cm is thick, stands 30min.The bacteria suspension 0.1mL prepared is drawn with liquid-transfering gun, is uniformly coated on tablet, 5min is stood, by the filter of diameter 6mm The scraps of paper are laid on tablet, and each culture dish pastes 3, and when patch pays attention to maintaining a certain distance between filter paper.Draw 0.1mL Yellow wingceltis platymiscium perfume (or spice) material medicinal extract solution is placed on filter paper, and using broad-spectrum antibiotic-tetracycline as positive control, concentration is selected as 5 μ g/mL draw 5 μ L with liquid-transfering gun and drop on filter paper, while using sterile water as blank control, being fallen in 37 DEG C of incubators Set culture for 24 hours, with vernier caliper measurement antibacterial circle diameter, the average value for as a result taking repetition to test.

3 results

This experimental selection Escherichia coli, staphylococcus aureus, bacillus subtilis are soaked as yellow wingceltis platymiscium perfume (or spice) material The research object of cream bacteriostatic activity test, according to upper table it is found that experimental selection sterile water is as negative control, broad-spectrum antibiotic- Tetracycline identifies the bacteriostasis property of Dalbergia perfume (or spice) material medicinal extract as positive control, the experimental results showed that above-mentioned yellow wingceltis platymiscium is fragrant Material medicinal extract has apparent antibacterial effect.

The effect of yellow wingceltis platymiscium perfume (or spice) material in treating microorganism infection to illustrate the invention below, lists some allusion quotations Type case：

1) it is used to treat intractable oral cavity ulcer

Not certain, female, 23 years old, normal hair canker sore since the childhood, often continuous recurrence, when breaking-out was in great pain, it is difficult to diet, The all doctors in Chinese and Western do not control, and in provincial capital, slow disease prevention hospital is slightly improved with Thalidomide in the recent period, but worry very much side effect (12 years old with Under child patient it is not yet established using the safety of Thalidomide, validity), this intractable oral cavity ulcer is fungi sense Dye, and often cause ulcer in immunity degradation after patient stays up late, begin to use Lignum Dalbergiae benthamii perfume (or spice) material fine powder in May, 2017, Daily not timing takes the powder to spread and spreads on ulcer surface, and as a result ulcer surface only needs can heal for 2 to 3 days, fast again than before, and recurs Interval is increasingly longer, after coordinating herbal treatment, until 2018 no longer recur substantially.

2) it is used to treat the infection of hand virus

Huang, man, 85 years old, in January, 2017, the burst two hand palms of the hand, arm and back is dry itches, was in symmetry, concurrent hickie, Hospital diagnosis is that virus infects, and gives and takes external application outside conventional anti-viral drug, and delay half a year takes oblique leaf santal material powder without good effect Last 1g is placed in 100ml disinfection ethyl alcohol, shakes up, and after impregnating 12 hours, dips immersion painting with cotton swab and puts on the skin in affected part, one day 4 to 6 Secondary, hickie subsides after three days, and disease of itching disappears, and restores after adhering to medication January, does not recur again.

3) it is used to treat tinea pedis

Tinea pedis is commonly called as tinea pedis, belongs to a kind of fungal infection, is highest one kind of incidence in dermatophytosis, is most common One of skin disease, thoroughly treatment is more difficult, and the course of disease is long, and long-standing problem patient, also the usually phase in entire kinsfolk Mutually infect.Although tinea pedis seems the scope for belonging to minor illness, but if being not treated in time, fungi can also infect its of patient His position, and lead to the tinea manuum, jock itch, onychomycosis etc. other dermatosis chronic diseases occur.The also patient of nearly half, may concurrent bacterial Infection, leads to the diseases such as angioleucitis, erysipelas, or even can cause the generation of septicemia, and then threatens the life of patient.

Referring to attached drawing 1, Hu, man, 38 years old, because working principle wears air-locked leather shoes for a long time, and commercial activity was more, It goes on business the standby shoes in the hotels Shi Chuan, tinea pedis is caught in cause, and skin heavy curtain is white at foot bifurcation, cracking, decortication, extremely itching, and has liquid to ooze Go out, occur red point on toe, it is fungal infection to show, and little Hua yellow wingceltis perfume (or spice) material powder is begun to use to mix alcohol painting on June 1st, 2018 Itch after foot bifurcation, one day desiccation only and in foot bifurcation, adheres to 15 days, and restore as before after coordinating shoe-sock sterilizing.

4) it is used to treat paddy-field dermatitis

Paddy-field dermatitis is most common skin disease in the production of China rural area, can be divided into poultry class schistosome cercarial dermatitis and leaching Two kinds of erosive type dermatitis, no specific medicament, often delay after illness it is refractory, in recent years with the use of fertilizer and pesticide and sanitary condition It improves, this disease incidence is reduced, but for part weakling, more difficult after catching an illness.

Mr. Wang, male, 39 years old.Element is without tinea pedis and paddy-field dermatitis medical history, but between 2016 to 2017, for several times when outdoor sports not Careful to fall into intermountain stagnant water ditch, because field condition does not have, dirty foot and shoes are unable to timely processing；And also summer rainstorm weather Visit Hong Kong Victoria Peak, rain rill water drenches cloth shoes, can not foot bath in time experience, after such a period of time, foot bifurcation starts gruel Lignum Dalbergiae benthamii perfume (or spice) material powder is used in rotten decortication then, and to impregnate 75% disinfection ethyl alcohol of Lignum Dalbergiae benthamii perfume (or spice) material powder outer together It puts on the skin in affected part, continuous two weeks, heals at erosion, observation half a year does not recur again.

5) it is used to treat onychomycosis

Onychomycosis is that one kind (referring to, toe) first disease caused by fungal infection, after (referring to, toe) first is infected, thickens, becomes It is crisp, fluff, cavity occur；Surface darkly, yellow, ash, Bai Dengse, the high area of air humidity adapts to fungi growing environment, so Incidence is higher.Oral medication onychomycosis medicine has Itraconazole and terbinafine HCl etc.；Externally applied drug has 10% tincture of iodine, salicylic acid With benzoic acid solution etc., but there is no specific drugs, and delay is refractory, and it is beautiful and physically and mentally healthy to seriously affect patient.

Tang, man, 55 years old, suffers from onychomycosis for many years, and all methods are invalid, take gamboge santal material, crushed 200 mesh, take about 0.5g, It is mixed thoroughly with appropriate disinfection ethyl alcohol mixing, takes mixture Tu affected part, gauze is used in combination suitably to wrap up, normal wear shoes socks, medicinal powder is done follow-up Drop disinfection ethyl alcohol, daily dressing, all diseases, which are known, after medication 2 weeks removes, and no longer recurs.

6) it is used to treat jock itch

Jock itch is a kind of more typical dermatophytid infection disease, and often hair is in groin, thigh root, vulva, anus week Enclose etc., especially multiple with male, since the hidrosis of private parts humidity grows suitable for fungi, simple antimycotic medicine for external application treatment is often difficult With radical cure.

Mr. Wang, male 35 years old, suffers from groin jock itch 20 years, once uses a variety of method processing such as compound Cortex Pseudolaricis tincture, liquid nitrogen, not It can effect a radical cure, groin pars affecta skin reddens, is dried, extremely itching, takes the disinfection ethyl alcohol that Yunnan Guizhou Province yellow wingceltis was impregnated and Yunnan Guizhou Province yellow wingceltis 200 mesh fine powders, put affected part on the skin outside, synchronize and take underpants disinfectant measure, after medication January, skin lightening, become profit, itch disappears, see It examines 1 year and does not recur again.

7) it is used to treat acne

The cause of disease of acne is more common in bacterium or fungal infection, at present also without special efficacy prescription.

Lee, female, acne breaking-out 10 years repeatedly, all methods are invalid, and because of working principle, the fragrant material powder of inconvenience on daytime just takes Lignum Dalbergiae benthamii perfume (or spice) material fine powder, being studied in France with vapor steaming and (supercritical fluid method extraction also can be used) (can be suitably added sodium hydroxide Solution) it is extracted into essential oil, with puts face portion affected part outside essential oil, after a week, acne disappears for medication, has preventing from scar, observes 1 year not It recurs again.

8) it is used to treat vinasse nose

Acne rosacea (rosacea) be it is a kind of betide mid-face, especially nose position with flush, blood capillary Enlargement of pipe and papule, the skin disease that warts is major clinical feature.Its course of disease is very long, when it is light when weight, it is touching refractory, according to its symptom Three type of erythema type, papulopustular type and pachydermatosis type can be often divided into, be mainly in a middle-aged person, it is common with women.After this disease occurs, seriously Patient face appearance is influenced, very big psychological burden and mental suffering are brought to patient.

Referring to attached drawing 2, dragon certain, female 50 years old, suffers from acne rosacea 20 years, and all methods are not controlled, and red fruit yellow wingceltis perfume (or spice) material powder is taken to impregnate 75% ethyl alcohol soak (per 100ml borneols containing 1g) outer Tu after one month, hence it is evident that improvement.

9) it is used to treat diabetes

Foot is a complicated target organ of this multisystem disease of diabetes.Diabetic is because of peripheral neuropathy Merge excessively high mechanical pressure with peripheral artery disease, the destruction of foot soft tissue and osteoarticular system and lopsided shape can be caused At, and then cause a series of foot problems, from slight nervous symptoms to serious ulcer, infection, vascular diseases, Charcot Arthropathy and Neuropathic fracture.If active treatment cannot fully solve the symptom and complication of lower limb appearance, can make At catastrophic consequence.

Referring to attached drawing 3, Wu, female 65 years old, suffers from diabetes 20 years, moves back rotten, does not close up long, fragrant with Lignum Dalbergiae benthamii after debridement Affected part is spread at material powder, is closed up after a week.

10) it is used to treat whelk

Mr. Wang, female, 30 years old, since puberty, the long acne of face's Chronic Intermittent about 15 years, each method method cannot root It controls, in March, 17, on its facial mask used in everyday, uniformly sprinkles the yellow wingceltis perfume (or spice) material fine powder of a small amount of 200 mesh, every time about 0.1g is applied with 10 to 15min then with conventional facial mask usage, adheres to 2 months, and as a result facial whelk obviously subsides, follow-up one Year is without recurrence.

Embodiment described above, only preferred embodiments of the invention are not therefore the Fan Yiben to limit the scope of the present invention The equivalent change or modification that feature and principle described in patent application the scope of the claims are done, should all be included in present patent application In range.

Claims

1. application of the yellow wingceltis platymiscium perfume (or spice) material in the drug for preparing treatment microorganism infection.

2. application of the yellow wingceltis platymiscium perfume (or spice) material according to claim 1 in the drug for preparing treatment microorganism infection, It is characterized in that：The yellow wingceltis platymiscium perfume (or spice) material is selected from Lignum Dalbergiae benthamii perfume (or spice) material, Burma's yellow wingceltis perfume (or spice) material, curved branch yellow wingceltis perfume (or spice) material, king kong Rattan perfume (or spice) material, gamboge santal material, Mengzi yellow wingceltis perfume (or spice) material, Hong Kong yellow wingceltis perfume (or spice) material, trunk rattan perfume (or spice) material, white sand yellow wingceltis perfume (or spice) material, Many-cleft Rosewood Fragrant material, narrow leaf yellow wingceltis perfume (or spice) material, stipule yellow wingceltis perfume (or spice) material, red fruit yellow wingceltis perfume (or spice) material, Yunnan Guizhou Province yellow wingceltis perfume (or spice) material, suede leaf yellow wingceltis perfume (or spice) material, the southern regions of the Yunnan Province are yellow Santal material, oblique leaf yellow wingceltis perfume (or spice) material, South Asia yellow wingceltis perfume (or spice) material, yellow wingceltis perfume (or spice) material, Ai Baidisi yellow wingceltis perfume (or spice) material, thorn yellow wingceltis perfume (or spice) material, Luigi Beccali Yellow wingceltis perfume (or spice) material, the people all Shandong yellow wingceltis perfume (or spice) material, Borneo's yellow wingceltis perfume (or spice) material, Clarke yellow wingceltis perfume (or spice) material, close colored yellow wingceltis perfume (or spice) material, cuneus yellow wingceltis are fragrant It is material, Coromandel yellow wingceltis perfume (or spice) material, Kui Ming yellow wingceltis perfume (or spice) material, Ke Disi yellow wingceltis perfume (or spice) material, close hair yellow wingceltis perfume (or spice) material, heterochromatic yellow wingceltis perfume (or spice) material, hard Coin rattan perfume (or spice) Cai, Ke vine leaf yellow wingceltis perfume (or spice) material, sickle fruit yellow wingceltis perfume (or spice) material, rust yellow wingceltis perfume (or spice) material, recessed leaf yellow wingceltis perfume (or spice) material, Forbes yellow wingceltis are fragrant Material, Gardner's yellow wingceltis perfume (or spice) material, Ge Shi yellow wingceltis perfume (or spice) material, thorniness yellow wingceltis perfume (or spice) material, this vast and boundless yellow wingceltis perfume (or spice) material, Hu Laite yellow wingceltis perfume (or spice) material, Ya Er Yellow wingceltis perfume (or spice) material, Johore's yellow wingceltis perfume (or spice) material hold big vast yellow wingceltis perfume (or spice) material, this Teller yellow wingceltis perfume (or spice) material of library, Maraba's yellow wingceltis perfume (or spice) material, moon fruit yellow wingceltis perfume Material, little Hua yellow wingceltis perfume (or spice) material, Pi Natubo yellow wingceltis perfume (or spice) material, leafy yellow wingceltis perfume (or spice) material, leather leaf yellow wingceltis perfume (or spice) material, net vein yellow wingceltis perfume (or spice) material, reason are looked into Hereby yellow wingceltis perfume (or spice) material, rust reddish yellow santal material, Sandakan yellow wingceltis perfume (or spice) material, this Cole's Gabriele Tarquini yellow wingceltis perfume (or spice) material, lunge yellow wingceltis perfume (or spice) material, smelly Huang Santal material, blueness yellow wingceltis perfume (or spice) material advanced in years, Te Siman yellow wingceltis perfume (or spice) material, Thomson yellow wingceltis perfume (or spice) material, support labor yellow wingceltis perfume (or spice) material, Ting Nifuli yellow wingceltises are fragrant It is one or more in material or Annan's yellow wingceltis perfume (or spice) material.

3. application of the yellow wingceltis platymiscium perfume (or spice) material according to claim 1 in the drug for preparing treatment microorganism infection, It is characterized in that：The microorganism infection is fungal infection.

4. application of the yellow wingceltis platymiscium perfume (or spice) material according to claim 1 in the drug for preparing treatment microorganism infection, It is characterized in that：The microorganism infection is bacterium infection.

5. application of the yellow wingceltis platymiscium perfume (or spice) material according to claim 1 in the drug for preparing treatment microorganism infection, It is characterized in that：The microorganism infection is viral infection.

6. application of the yellow wingceltis platymiscium perfume (or spice) material according to claim 1 in the drug for preparing treatment microorganism infection, It is characterized in that：The microorganism infection is the ash of the pruitus of microorganism infection, the tinea pedis of microorganism infection, microorganism infection The glycosuria of nail, the jock itch of microorganism infection, the canker sore of microorganism infection, the acne of microorganism infection, microorganism infection The vinasse nose of foot disease or microorganism infection.

7. yellow wingceltis platymiscium perfume (or spice) material according to any one of claims 1 to 6 is in the drug for preparing treatment microorganism infection Application, it is characterised in that：By the yellow wingceltis platymiscium perfume (or spice) material grind into powder, by suitable solvent by the yellow wingceltis platymiscium Fragrant material extracts, then by detaching, refining, concentrate and the yellow wingceltis platymiscium perfume (or spice) material extract is made in drying process.

8. yellow wingceltis platymiscium perfume (or spice) material according to any one of claims 1 to 6 is in the drug for preparing treatment microorganism infection Application, it is characterised in that：The yellow wingceltis platymiscium perfume (or spice) material essence is obtained by extraction by steam distillation or supercritical fluid method Oil.

9. yellow wingceltis platymiscium perfume (or spice) material according to any one of claims 1 to 6 is in the drug for preparing treatment microorganism infection Application, it is characterised in that：The yellow wingceltis platymiscium perfume (or spice) material can be with Asian puccoon, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, dragon's blood, dye yam, clam, ginseng, ice One or more carry out compatible uses in piece, agalloch eaglewood or santal.

10. yellow wingceltis platymiscium perfume (or spice) material according to any one of claims 1 to 6 is in the drug for preparing treatment microorganism infection Application, it is characterised in that：The yellow wingceltis platymiscium perfume (or spice) material is used cooperatively with medical disinfecting solution.