CN108653799A - A kind of preparation method of hydrophilic antibiotic silicon rubber medical dressing - Google Patents
A kind of preparation method of hydrophilic antibiotic silicon rubber medical dressing Download PDFInfo
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
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- A—HUMAN NECESSITIES
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- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0004—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing inorganic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0019—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
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Abstract
The invention discloses a kind of preparation methods of hydrophilic antibiotic silicon rubber medical dressing, specifically include following steps：The mixed liquor of the nano-titanium oxide of Chitosan-coated is prepared first, and then using plasma processing silicon rubber prepares activation silicon rubber；Activation silicon rubber is added in the ethanol solution of silane coupling agent and handles, be placed on stir process in the aqueous solution of succinic acid imidodicarbonic diamide, surface modified silicon rubber is made；It will finally be ultrasonically treated, take out in the mixed liquor for the nano-titanium oxide that the silicon rubber that surface is modified is placed in Chitosan-coated, it is dry, medical dressing is made.Medical dressing good hydrophilic property produced by the present invention can effectively facilitate the quality of healing and the healing of the surface of a wound, and anti-microbial property is good, and the medical dressing is prepared simply, and manufacturing cost is low.
Description
Technical field：
The present invention relates to field of medical materials, are specifically related to a kind of preparation side of hydrophilic antibiotic silicon rubber medical dressing
Method.
Background technology：
Covering of the medical dressing as wound can substitute impaired skin and play temporarily in wound healing process
The barrier action of when property avoids or controls wound infection, is provided with the environment conducive to wound healing.Domestic and international medical dressing market is non-
There are the tens million of person-times of skin injuries caused by contingency or operation, the pressure brought by aging of population in Chang Ju great, the country every year
Chronic skin injury etc. caused by the diseases such as sore, diabetes, varication so that the use of national medical dressing greatly increases.
Dressing now is roughly divided into two classes, i.e. traditional dressing and modern dressing, and traditional dressing is normal gauze, and modern
Dressing is divided into as the dressing of synthetic fibers class, poly film class dressing and foaming polymer class dressing.But traditional class dressing is using
Wound surface dehydration, bacterium can be caused to penetrate readily through, easily stick together wound in the process.So modern dressing application is more extensive, but
It is the modern dressing manufacturing cost height used at present, poor air permeability, functionality are bad.
Invention content：
In view of the deficiencies of the prior art, it is an object of the present invention to provide a kind of systems of hydrophilic antibiotic silicon rubber medical dressing
Preparation Method, medical dressing made from this method have wound certain protective effect, can be effectively improved the healing rate of wound,
Healing quality is improved, inhibiting bacteria and diminishing inflammation effect is good.
To achieve the above object, the present invention uses following technical scheme：
A kind of preparation method of hydrophilic antibiotic silicon rubber medical dressing, includes the following steps：
(1) use sol-gal process that the hexamethylene colloidal sol of titaniferous is made；Then chitosan is dissolved in deionized water and is made
Chitosan solution, and chitosan solution obtained is slowly dropped in the hexamethylene colloidal sol of titaniferous obtained above, side is added dropwise
Side is stirred, and continues to stir 30min under 800-1500 revs/min of rotating speed after being added dropwise, chitosan packet is made after stirring
The mixed liquor of the nano-titanium oxide covered；
(2) silicon rubber using plasma is handled, activation silicon rubber is made；
(3) activation silicon rubber obtained above is added in the ethanol solution of silane coupling agent and is surface-treated, so
The silicon rubber after surface treatment is placed in the aqueous solution of amber pyromellitic imide afterwards, the stir process 1-2h at 40-60 DEG C,
It takes out, it is dry, the silicon rubber that surface is modified is made；
(4) silicon rubber that surface is modified is placed in the mixed liquor of the nano-titanium oxide of Chitosan-coated made from step (1)
In, it is ultrasonically treated 1-6min under 500-1000W power, takes out, washing to neutrality is dry, and medical dressing is made.
As a preferred embodiment of the above technical solution, in step (1), the hexamethylene colloidal sol of titaniferous is made in the sol-gal process
Detailed process is：After hexamethylene and absolute ethyl alcohol are mixed evenly, triethylamine is added dropwise and continues to stir, metatitanic acid four is finally added dropwise
After stirring evenly, mixed liquor is placed in reaction kettle for butyl ester, sealing, is reacted 20h at 150 DEG C, is made.
As a preferred embodiment of the above technical solution, the volume ratio of the hexamethylene, absolute ethyl alcohol, triethylamine, butyl titanate
It is 50:5:1：1.
As a preferred embodiment of the above technical solution, in step (1), the mass concentration of the chitosan aqueous solution is 7-22%.
As a preferred embodiment of the above technical solution, chitosan, nano-titanium oxide mass ratio be (1.33-2.06)：1.
As a preferred embodiment of the above technical solution, in step (2), the condition of the corona treatment is：Vacuum degree is 10-
12Pa, processing time 10-15min.
As a preferred embodiment of the above technical solution, in step (3), it is described activation silicon rubber, silane coupling agent mass ratio be
(6-11)：1.
As a preferred embodiment of the above technical solution, the mass ratio of the silicon rubber after the surface treatment, amber pyromellitic imide
It is 1：(0.03-0.06).
As a preferred embodiment of the above technical solution, the mass ratio of surface is modified silicon rubber, chitosan is 1：(0.1-0.5).
The invention has the advantages that：
For the present invention using silicon rubber as the matrix of medical dressing, silicon rubber can with some by corona treatment rear surface
Then the active site of reaction is handled so that silastic surface is grafted with silicon in the ethanol solution of silane coupling agent
Alkane coupling agent, to silastic surface introduce can reactive group, finally add it to the aqueous solution of amber pyromellitic imide
In reacted at a certain temperature, modified silastic surface carry more active group；
The present invention uses sol-gal process that titaniferous colloidal sol is made first, and chitosan solution obtained is then added dropwise, and stirring is heavy
It forms sediment, chitosan can effectively be coated on nano-titanium oxide surface, effectively improve the dispersibility of nano-titanium oxide, and it can have grafting
In modified silastic surfaces, the hydrophily and anti-microbial property of matrix are effectively improved, the healing of the surface of a wound can be effectively facilitated,
Improve the quality of wound healing.
Specific implementation mode：
In order to better understand the present invention, below by embodiment, the present invention is further described, and embodiment is served only for solving
The present invention is released, any restriction will not be constituted to the present invention.
Embodiment 1
A kind of preparation method of hydrophilic antibiotic silicon rubber medical dressing, includes the following steps：
(1) use sol-gal process that the hexamethylene colloidal sol of titaniferous is made；Then chitosan is dissolved in deionized water and is made
Mass concentration is 7% chitosan solution, and chitosan solution obtained is slowly dropped to the hexamethylene of titaniferous obtained above
It in alkane colloidal sol, is stirred when being added dropwise, continues to stir 30min under 800 revs/min of rotating speed after being added dropwise, be made after stirring
Obtain the mixed liquor of the nano-titanium oxide of Chitosan-coated；Wherein, chitosan, nano-titanium oxide mass ratio be 1.33：1；
(2) silicon rubber using plasma is handled, activation silicon rubber is made；
(3) activation silicon rubber obtained above is added in the ethanol solution of silane coupling agent and is surface-treated, so
The silicon rubber after surface treatment is placed in the aqueous solution of amber pyromellitic imide afterwards, the stir process 1h at 40 DEG C, is taken out,
It is dry, the silicon rubber that surface is modified is made；Wherein, it is described activation silicon rubber, silane coupling agent mass ratio be 6：1；At surface
The mass ratio of silicon rubber, amber pyromellitic imide after reason is 1：0.03；
(4) silicon rubber that surface is modified is placed in the mixed liquor of the nano-titanium oxide of Chitosan-coated made from step (1)
In, it is ultrasonically treated 1-6min under 500W power, takes out, washing to neutrality is dry, and medical dressing is made；Wherein, surface is modified
Silicon rubber, chitosan mass ratio be 1：0.1.
Embodiment 2
A kind of preparation method of hydrophilic antibiotic silicon rubber medical dressing, includes the following steps：
(1) use sol-gal process that the hexamethylene colloidal sol of titaniferous is made；Then chitosan is dissolved in deionized water and is made
Mass concentration is 22% chitosan solution, and chitosan solution obtained is slowly dropped to the hexamethylene of titaniferous obtained above
It in alkane colloidal sol, is stirred when being added dropwise, continues to stir 30min under 1500 revs/min of rotating speed after being added dropwise, be made after stirring
Obtain the mixed liquor of the nano-titanium oxide of Chitosan-coated；Wherein, chitosan, nano-titanium oxide mass ratio be 2.06：1；
(2) silicon rubber using plasma is handled, activation silicon rubber is made；
(3) activation silicon rubber obtained above is added in the ethanol solution of silane coupling agent and is surface-treated, so
The silicon rubber after surface treatment is placed in the aqueous solution of amber pyromellitic imide afterwards, the stir process 2h at 60 DEG C, is taken out,
It is dry, the silicon rubber that surface is modified is made；Wherein, it is described activation silicon rubber, silane coupling agent mass ratio be 11：1；At surface
The mass ratio of silicon rubber, amber pyromellitic imide after reason is 1：0.06；
(4) silicon rubber that surface is modified is placed in the mixed liquor of the nano-titanium oxide of Chitosan-coated made from step (1)
In, it is ultrasonically treated 1-6min under 1000W power, takes out, washing to neutrality is dry, and medical dressing is made；Wherein, surface is modified
Silicon rubber, chitosan mass ratio be 1：0.5.
Embodiment 3
A kind of preparation method of hydrophilic antibiotic silicon rubber medical dressing, includes the following steps：
(1) use sol-gal process that the hexamethylene colloidal sol of titaniferous is made；Then chitosan is dissolved in deionized water and is made
Mass concentration is 10% chitosan solution, and chitosan solution obtained is slowly dropped to the hexamethylene of titaniferous obtained above
It in alkane colloidal sol, is stirred when being added dropwise, continues to stir 30min under 900 revs/min of rotating speed after being added dropwise, be made after stirring
Obtain the mixed liquor of the nano-titanium oxide of Chitosan-coated；Wherein, chitosan, nano-titanium oxide mass ratio be 1.53：1；
(2) silicon rubber using plasma is handled, activation silicon rubber is made；
(3) activation silicon rubber obtained above is added in the ethanol solution of silane coupling agent and is surface-treated, so
The silicon rubber after surface treatment is placed in the aqueous solution of amber pyromellitic imide afterwards, and stir process 1.2h, takes at 45 DEG C
Go out, it is dry, the silicon rubber that surface is modified is made；Wherein, it is described activation silicon rubber, silane coupling agent mass ratio be 7：1；Surface
Treated silicon rubber, amber pyromellitic imide mass ratio be 1：0.035；
(4) silicon rubber that surface is modified is placed in the mixed liquor of the nano-titanium oxide of Chitosan-coated made from step (1)
In, it is ultrasonically treated 1-6min under 600W power, takes out, washing to neutrality is dry, and medical dressing is made；Wherein, surface is modified
Silicon rubber, chitosan mass ratio be 1：0.2.
Embodiment 4
A kind of preparation method of hydrophilic antibiotic silicon rubber medical dressing, includes the following steps：
(1) use sol-gal process that the hexamethylene colloidal sol of titaniferous is made；Then chitosan is dissolved in deionized water and is made
Mass concentration is 13% chitosan solution, and chitosan solution obtained is slowly dropped to the hexamethylene of titaniferous obtained above
It in alkane colloidal sol, is stirred when being added dropwise, continues to stir 30min under 1000 revs/min of rotating speed after being added dropwise, be made after stirring
Obtain the mixed liquor of the nano-titanium oxide of Chitosan-coated；Wherein, chitosan, nano-titanium oxide mass ratio be 1.75：1；
(2) silicon rubber using plasma is handled, activation silicon rubber is made；
(3) activation silicon rubber obtained above is added in the ethanol solution of silane coupling agent and is surface-treated, so
The silicon rubber after surface treatment is placed in the aqueous solution of amber pyromellitic imide afterwards, and stir process 1.4h, takes at 50 DEG C
Go out, it is dry, the silicon rubber that surface is modified is made；Wherein, it is described activation silicon rubber, silane coupling agent mass ratio be 8：1；Surface
Treated silicon rubber, amber pyromellitic imide mass ratio be 1：0.04；
(4) silicon rubber that surface is modified is placed in the mixed liquor of the nano-titanium oxide of Chitosan-coated made from step (1)
In, it is ultrasonically treated 1-6min under 700W power, takes out, washing to neutrality is dry, and medical dressing is made；Wherein, surface is modified
Silicon rubber, chitosan mass ratio be 1：0.02.
Embodiment 5
A kind of preparation method of hydrophilic antibiotic silicon rubber medical dressing, includes the following steps：
(1) use sol-gal process that the hexamethylene colloidal sol of titaniferous is made；Then chitosan is dissolved in deionized water and is made
Mass concentration is 15% chitosan solution, and chitosan solution obtained is slowly dropped to the hexamethylene of titaniferous obtained above
It in alkane colloidal sol, is stirred when being added dropwise, continues to stir 30min under 1100 revs/min of rotating speed after being added dropwise, be made after stirring
Obtain the mixed liquor of the nano-titanium oxide of Chitosan-coated；Wherein, chitosan, nano-titanium oxide mass ratio be 1.86：1；
(2) silicon rubber using plasma is handled, activation silicon rubber is made；
(3) activation silicon rubber obtained above is added in the ethanol solution of silane coupling agent and is surface-treated, so
The silicon rubber after surface treatment is placed in the aqueous solution of amber pyromellitic imide afterwards, and stir process 1.6h, takes at 50 DEG C
Go out, it is dry, the silicon rubber that surface is modified is made；Wherein, it is described activation silicon rubber, silane coupling agent mass ratio be 9：1；Surface
Treated silicon rubber, amber pyromellitic imide mass ratio be 1：0.045；
(4) silicon rubber that surface is modified is placed in the mixed liquor of the nano-titanium oxide of Chitosan-coated made from step (1)
In, it is ultrasonically treated 1-6min under 800W power, takes out, washing to neutrality is dry, and medical dressing is made；Wherein, surface is modified
Silicon rubber, chitosan mass ratio be 1：0.04.
Embodiment 6
A kind of preparation method of hydrophilic antibiotic silicon rubber medical dressing, includes the following steps：
(1) use sol-gal process that the hexamethylene colloidal sol of titaniferous is made；Then chitosan is dissolved in deionized water and is made
Mass concentration is 19% chitosan solution, and chitosan solution obtained is slowly dropped to the hexamethylene of titaniferous obtained above
It in alkane colloidal sol, is stirred when being added dropwise, continues to stir 30min under 1300 revs/min of rotating speed after being added dropwise, be made after stirring
Obtain the mixed liquor of the nano-titanium oxide of Chitosan-coated；Wherein, chitosan, nano-titanium oxide mass ratio be 2.02：1；
(2) silicon rubber using plasma is handled, activation silicon rubber is made；
(3) activation silicon rubber obtained above is added in the ethanol solution of silane coupling agent and is surface-treated, so
The silicon rubber after surface treatment is placed in the aqueous solution of amber pyromellitic imide afterwards, and stir process 1.8h, takes at 55 DEG C
Go out, it is dry, the silicon rubber that surface is modified is made；Wherein, it is described activation silicon rubber, silane coupling agent mass ratio be 10：1；Table
The mass ratio of silicon rubber, amber pyromellitic imide after surface treatment is 1：0.05；
(4) silicon rubber that surface is modified is placed in the mixed liquor of the nano-titanium oxide of Chitosan-coated made from step (1)
In, it is ultrasonically treated 1-6min under 900W power, takes out, washing to neutrality is dry, and medical dressing is made；Wherein, surface is modified
Silicon rubber, chitosan mass ratio be 1：0.45.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto,
Any one skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its
Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.
Claims (9)
1. a kind of preparation method of hydrophilic antibiotic silicon rubber medical dressing, which is characterized in that include the following steps：
(1) use sol-gal process that the hexamethylene colloidal sol of titaniferous is made；Then chitosan obtained shell is dissolved in deionized water to gather
Sugar juice, and chitosan solution obtained is slowly dropped in the hexamethylene colloidal sol of titaniferous obtained above, it is stirred when being added dropwise
It mixes, continues to stir 30min under 800-1500 revs/min of rotating speed after being added dropwise, Chitosan-coated is made after stirring
The mixed liquor of nano-titanium oxide；
(2) silicon rubber using plasma is handled, activation silicon rubber is made；
(3) activation silicon rubber obtained above is added in the ethanol solution of silane coupling agent and is surface-treated, then passed through
The silicon rubber crossed after surface treatment is placed in the aqueous solution of amber pyromellitic imide, and stir process 1-2h, takes at 40-60 DEG C
Go out, it is dry, the silicon rubber that surface is modified is made；
(4) silicon rubber that surface is modified is placed in the mixed liquor of the nano-titanium oxide of Chitosan-coated made from step (1),
It is ultrasonically treated 1-6min under 500-1000W power, takes out, washing to neutrality is dry, and medical dressing is made.
2. a kind of preparation method of hydrophilic antibiotic silicon rubber medical dressing as described in claim 1, which is characterized in that step
(1) in, the detailed process that the hexamethylene colloidal sol of titaniferous is made in the sol-gal process is：Hexamethylene and absolute ethyl alcohol are mixed and stirred
After mixing uniformly, triethylamine is added dropwise and continues to stir, butyl titanate is finally added dropwise, after stirring evenly, mixed liquor is placed in reaction kettle
It is interior, it seals, reacts 20h at 150 DEG C, be made.
3. a kind of preparation method of hydrophilic antibiotic silicon rubber medical dressing as claimed in claim 2, it is characterised in that：It is described
Hexamethylene, absolute ethyl alcohol, triethylamine, butyl titanate volume ratio be 50:5:1：1.
4. a kind of preparation method of hydrophilic antibiotic silicon rubber medical dressing as described in claim 1, it is characterised in that：Step
(1) in, the mass concentration of the chitosan aqueous solution is 7-22%.
5. a kind of preparation method of hydrophilic antibiotic silicon rubber medical dressing as described in claim 1, it is characterised in that：Shell is poly-
Sugared, nano-titanium oxide mass ratio is (1.33-2.06)：1.
6. a kind of preparation method of hydrophilic antibiotic silicon rubber medical dressing as described in claim 1, which is characterized in that step
(2) in, the condition of the corona treatment is：Vacuum degree is 10-12Pa, processing time 10-15min.
7. a kind of preparation method of hydrophilic antibiotic silicon rubber medical dressing as described in claim 1, it is characterised in that：Step
(3) in, it is described activation silicon rubber, silane coupling agent mass ratio be (6-11)：1.
8. a kind of preparation method of hydrophilic antibiotic silicon rubber medical dressing as described in claim 1, it is characterised in that：It is described
The mass ratio of silicon rubber, amber pyromellitic imide after surface treatment is 1：(0.03-0.06).
9. a kind of preparation method of hydrophilic antibiotic silicon rubber medical dressing as described in claim 1, it is characterised in that：Surface
The mass ratio of modified silicon rubber, chitosan is 1：(0.1-0.5).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810422574.6A CN108653799B (en) | 2018-05-05 | 2018-05-05 | Preparation method of hydrophilic antibacterial silicone rubber medical dressing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810422574.6A CN108653799B (en) | 2018-05-05 | 2018-05-05 | Preparation method of hydrophilic antibacterial silicone rubber medical dressing |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108653799A true CN108653799A (en) | 2018-10-16 |
| CN108653799B CN108653799B (en) | 2021-11-19 |
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| CN102731789A (en) * | 2012-07-11 | 2012-10-17 | 常州大学 | Preparation method of surface hydrophilic silicon rubber |
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| CN104721875A (en) * | 2015-03-18 | 2015-06-24 | 华南理工大学 | Hydrophilic silicone rubber wound dressing and preparation method thereof |
| CN105031711A (en) * | 2015-06-17 | 2015-11-11 | 郑州大学 | Collagen/chitosan composite sponge biological dressing and preparation method thereof |
| CN105831154A (en) * | 2016-04-07 | 2016-08-10 | 济南钛盾生物科技有限公司 | Titanium dioxide antibacterial sol and preparation method thereof |
| WO2017075320A1 (en) * | 2015-10-31 | 2017-05-04 | Dermalink Technologies, Inc. | Skin adhesives, antimicrobial compositions, articles, and methods for the use thereof |
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| CN102731789A (en) * | 2012-07-11 | 2012-10-17 | 常州大学 | Preparation method of surface hydrophilic silicon rubber |
| CN103726319A (en) * | 2013-12-09 | 2014-04-16 | 科凯精细化工（上海）有限公司 | Nano-TiO2 loaded chitosan compound and preparation method thereof |
| CN104479155A (en) * | 2014-12-26 | 2015-04-01 | 北京林业大学 | Preparation method of chitosan/titanium dioxide sol antibacterialpackaging film |
| CN104721875A (en) * | 2015-03-18 | 2015-06-24 | 华南理工大学 | Hydrophilic silicone rubber wound dressing and preparation method thereof |
| CN105031711A (en) * | 2015-06-17 | 2015-11-11 | 郑州大学 | Collagen/chitosan composite sponge biological dressing and preparation method thereof |
| WO2017075320A1 (en) * | 2015-10-31 | 2017-05-04 | Dermalink Technologies, Inc. | Skin adhesives, antimicrobial compositions, articles, and methods for the use thereof |
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