CN108451837A

CN108451837A - A kind of whitening liquid-crystal composition and its preparation method and application

Info

Publication number: CN108451837A
Application number: CN201810690246.4A
Authority: CN
Inventors: 刘卫; 洪延涵; 闻庆; 卞思静; 韩非; 郭赛红
Original assignee: Wuhan Bai Si Kay Biotechnology Co Ltd
Current assignee: Wuhan Bai Si Kay Biotechnology Co Ltd
Priority date: 2018-06-28
Filing date: 2018-06-28
Publication date: 2018-08-28
Anticipated expiration: 2038-06-28
Also published as: CN108451837B

Abstract

The present invention relates to cosmetic fields, provide a kind of whitening liquid-crystal composition, and raw material includes whitening active ingredients and LCD vector；The whitening active ingredients include promoting excoriation class active material, tyrosinase inhibitor, melanosome being inhibited to migrate at least two in class active material, anti-oxidation active substance, anti-inflammatory activity substance and anti-saccharogenic activity substance；The raw material of the LCD vector includes liquid crystal emulsifier, assistant for emulsifying agent and emulsifing thickener；The whitening liquid-crystal composition further includes the liquid fatty substance and water for dissolving whitening active ingredients and LCD vector raw material.The present invention is loaded by the compounding and LCD vector of different whitening mechanism, achieve significant synergistic function, stability, the whitening effect of whitening liquid-crystal composition can be significantly improved, while solving the problems, such as that load high concentration whitening active ingredients are easy to cause skin irritatin.

Description

A kind of whitening liquid-crystal composition and its preparation method and application

Technical field

The present invention relates to cosmetic fields, and in particular to a kind of whitening liquid-crystal composition and its preparation method and application.

Background technology

The pale skin of health is the hot spot of most of women concerns, and Nails are always advocated " skin coagulates such as fat as avenged " Whitening effect.But whitening class skin care item generally existing problems on the market at present：

1. lightening mechanism is single：Formation and metastasis of the most products product only for a kind of melanin, cannot achieve Full effect whitening；

2. product stability is poor：For most of whitening products of market when making, whitening composition is to be directly appended to be formulated In, it easily leads to product and changes colour, is spoiled, or even lotion occur and be layered, be thicker；

3. whitening efficiency is low：Since skin has barrier by oneself, whitening active ingredients are difficult to infiltrate through skin base layer, Wu Fazhi It connects and acts on melanocyte, substantially reduce whitening efficiency；

4. easily causing skin irritatin：Common whitening agent, such as glabridin, Symwhite-337, are directly appended to protect In skin product, if concentration control is improper, easily cause skin irritatin or even inflammation.

Therefore, promote active ingredient infiltration, improve stability, reduce stimulation to be that whitening class cosmetics are realizing both effectiveness mistake Problem urgently to be resolved hurrily in journey.

Invention content

Whitening product effect is single, stability is poor, whitening effect is insufficient, easy initiation in order to solve in the prior art by the present invention The problem of skin irritatin, provides a kind of whitening liquid-crystal composition, can load the whitening composition of high concentration, effectively control whitening Active constituent is sustained, and promotes skin permeation amount, and reducing stimulates and improve whitening effect.

To solve the above-mentioned problems, the present invention provides following technical schemes：

The present invention provides a kind of whitening liquid-crystal composition, raw material includes whitening active ingredients and LCD vector；

The whitening active ingredients include promoting excoriation class active material, tyrosinase inhibitor, inhibiting melanocyte small Body migrates at least two in class active material, anti-oxidation active substance, anti-inflammatory activity substance and anti-saccharogenic activity substance；

The raw material of the LCD vector includes liquid crystal emulsifier, assistant for emulsifying agent and emulsifing thickener；

The whitening liquid-crystal composition further includes the liquid fat for dissolving whitening active ingredients and/or LCD vector raw material Matter and water.

Preferably, based on the gross mass of whitening liquid-crystal composition：

When whitening active ingredients include promoting excoriation class active material, excoriation class active material is promoted to account for The 0.1%~3% of the gross mass of whitening liquid-crystal composition；

When whitening active ingredients include tyrosinase inhibitor, tyrosinase inhibitor accounts for whitening liquid-crystal composition The 0.1%~10% of gross mass；

When whitening active ingredients include that melanosome is inhibited to migrate class active material, melanosome migration class is inhibited to live Property substance accounts for the 0.1%~10% of the gross mass of whitening liquid-crystal composition；

When whitening active ingredients include anti-oxidation active substance, anti-oxidation active substance accounts for whitening liquid-crystal composition The 0.1%~5% of gross mass；

When whitening active ingredients include anti-inflammatory activity substance, anti-inflammatory activity substance accounts for whitening liquid-crystal composition The 0.1%~5% of gross mass；

When whitening active ingredients include anti-saccharogenic activity substance, anti-saccharogenic activity substance accounts for whitening liquid-crystal composition The 0.1%~5% of gross mass.

Preferably, based on the gross mass of whitening liquid-crystal composition：

The material quality percentage of the LCD vector is：Liquid crystal emulsifier 1~10%, assistant for emulsifying agent 2~25% and Emulsifing thickener 0.01~5%.

Preferably, according to the gross mass meter of whitening liquid-crystal composition, the liquid fatty substance accounts for the total of whitening liquid-crystal composition The 2%~35% of quality, the water account for the 5%~35% of the gross mass of whitening liquid-crystal composition.

Preferably, it is described promote excoriation class active material in salicylic acid, Papain and semen armeniacae amarae one Kind is a variety of；

The tyrosinase inhibitor is selected from glabridin, Symwhite-337, alpha-arbutin, ferulic acid and kojic acid In it is one or more；

The inhibition melanosome migration class active material is selected from one or both of niacinamide, heparin sodium；

The anti-oxidation active substance is selected from vitamin C and its derivative, vitamin E and its derivative, polypeptide and hydroxyl It is one or more in base tyrosol；

The anti-inflammatory activity substance is selected from one or both of glycyrrhizic acid hypo acid and Paeonol；

The anti-saccharogenic activity substance be selected from tea polyphenols, silymarin, phloretin, phloridzin, Quercetin, curcumin and It is one or more in alpha-lipoic acid.

Preferably, it is single hard to be selected from polyox-yethylene-polyoxypropylene block copolymer, polyoxyethylene (40) for the liquid crystal emulsifier Resin acid ester, polyglycereol-3-methyl distearate, soybean lecithin, hydrolecithin, cetostearyl alcohol (and) cocoyl Glucoside, C14-22 alcohol (and) C12-20 alkyl glucosides, cocoyl glucoside (and) lauric alcohol, C22 alcohol alkyl phosphate, whale Wax stearyl glucoside, hydroxystearyl alcohol and hydroxy stearate glucosides, arachidic alcohol and docosyl alcohol and arachidic alcohol glucoside, docosyl alcohol alkane Base phosphate, cetostearyl alcohol and cetearyl glucoside, cetostearyl alcohol and cocoyl glucoside and myristyl Portugal It is one or more in glucosides；

The assistant for emulsifying agent is selected from stearyl alcohol, hexylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, glycerine, 1,3- fourths two It is one or more in alcohol and 1,2- pentanediols；

The emulsifing thickener be selected from carbomer, hydroxy ethyl methacrylate, polyacrylamide, polyacrylate -13 (and) Polyisobutene (and) polysorbate -20, polyvinylpyrrolidone, hypromellose, sodium carboxymethylcellulose, acrylic acid Sodium/sodium acryloyldimethyl taurate copolymers (and) isohexadecane (and) Polyoxyethylene Sorbitan Monooleate, guar gum and Arabic gum In it is one or more.

Preferably, the liquid fatty substance is selected from isopropyl myristate, isopropyl palmitate, Miglyol 812, pungent Sour Triglyceride DDD, polyethylene glycol glyceryl laurate ester, polyethylene glycol tristerin, glyceryl linoleate, propylene glycol Single caprylate, two pungent capric acid propylene glycol esters, pungent capric acid cocoa butter, isononyl isononanoate, glyceryl triacetate, dimethicone, It is one or more in vitamin E, white oil, squalene, sunflower oil and soybean oil.

The present invention also provides the preparation methods of the whitening liquid-crystal composition described in above-mentioned technical proposal, including following step Suddenly：

A, liquid crystal emulsifier, water-insoluble whitening active ingredients are dissolved with liquid fatty, obtains oil phase；

B, assistant for emulsifying agent and emulsifing thickener are obtained into water phase with water dissolution；

C, water-soluble whitening active ingredients are obtained into whitening active ingredients aqueous solution with water dissolution；

D, the water phase mixing and emulsifying for obtaining the oil phase that step A is obtained with step B, micronized processing obtain a micron fraction Granular media；

E, the micrometre level dispersoid mixing and emulsifying for obtaining the whitening active ingredients aqueous solution that step C is obtained with step D, receives Riceization processing, obtains whitening liquid-crystal composition；

Limitation without sequencing between described step A, B and C.

Preferably, in the step D, micronized processing is shear treatment to micron order；

In the step E, nanosizing processing is handled for shearing, high-pressure homogeneous or high pressure microjet to nanoscale.

The present invention also provides application of the whitening liquid-crystal composition in preparing cosmetics described in preceding solution.

Compared with prior art, technical solution provided by the invention has the following advantages：

The present invention provides a kind of whitening liquid-crystal composition, raw material includes whitening active ingredients and LCD vector；Described U.S. White active constituent includes promoting excoriation class active material, tyrosinase inhibitor, melanosome being inhibited to migrate class active matter At least two in matter, anti-oxidation active substance, anti-inflammatory activity substance and anti-saccharogenic activity substance；The LCD vector Raw material includes liquid crystal emulsifier, assistant for emulsifying agent and emulsifing thickener；The whitening liquid-crystal composition further includes for dissolving U.S. The liquid fatty substance and water of white active constituent and LCD vector raw material.The compounding and liquid that the present invention passes through different whitening mechanism components It is brilliant carrier loaded, significant synergistic function is achieved, stability, the whitening effect of whitening liquid-crystal composition can be significantly improved Fruit, while solving the problems, such as that load high concentration whitening active ingredients are easy to cause skin irritatin.

Cosmetics are made in whitening composition directly addition, are easy to cause product and go bad, are layered, stability is poor.LCD vector master It applies in field of medicaments, and the self stability of liquid crystal structure, there is also certain problem, liquid crystal structure can be with storage The problem of time is reduced.Whitening liquid-crystal composition provided by the invention is using liquid crystal emulsifier, assistant for emulsifying agent and emulsification thickening Agent is material construction LCD vector, can significantly improve the load capacity of LCD vector, form stable liquid crystal structure.Test table Bright, half an hour is not stratified, nothing for centrifugation in the centrifuge that rotating speed is 12000r/min for whitening liquid-crystal composition provided by the invention It is precipitated；Preserve that 3 months not stratified, non-discolouring, liquid crystal structure has no reduction at 45 DEG C；Stored under room temperature 3 years it is not stratified, constant Color, stability are good.

The present invention fully takes into account the influence of skin texture state and skin renewal period for the colour of skin, has selected promotion Excoriation class active material, tyrosinase inhibitor, inhibit melanosome migration class active material, anti-oxidation active substance, At least two in anti-inflammatory activity substance and anti-saccharogenic activity substance, by more targetings be inherently eliminated color spot with The non-uniform phenomenon of the colour of skin realizes that multiple target point imitates skin whitening effect entirely.

Whitening composition in conventional cosmetic cannot add too much, otherwise be easy to cause skin irritatin.The present invention utilizes liquid Brilliant carrier in carrier inside, gradually discharges a large amount of whitening active substance encapsulation using its sustained release performance, can either reduce U.S. White product can make skin absorb more whitening active substances the irritation of skin by sustained release whitening material, Improve whitening effect.

The LCD vector that the present invention uses has unique internal channel structure and huge film surface product, can coat The whitening active substance of opposed polarity and content.Water-soluble whitening active substance is encapsulated in the aqueous channels of LCD vector In, fat-soluble whitening active substance can be encapsulated in the bimolecular lamellar lipid membrane of liquid crystal, compared to conventional W/O or O/W types Emulsion encapsulating active principle it is more and stability of the whitening active substance under light, heat can be effectively improved.

The structure of oil/cuticula/water of whitening liquid-crystal composition structure provided by the invention and human skin is very much like, It can mutually be adsorbed with the cuticula of skin, promote effective infiltration of whitening active ingredients, to enhance whitening effect.

Whitening liquid-crystal composition provided by the invention has excellent performance of keeping humidity and good skin sense, and water lock effect is good, And the water lock time is long.

Whitening liquid-crystal composition provided by the invention can be used in preparing cosmetics, and cosmetics is made to have efficient whitening, skin Feel excellent, the advantage that irritation is small, efficient moisture-retention and stability are good.Meanwhile whitening liquid-crystal composition provided by the invention Structure can also excite the natural regeneration function of skin, accelerate skin metabolism, act synergistically, realize with whitening active ingredients Effective whitening effect.

Description of the drawings

Fig. 1 is that the whitening liquid-crystal composition that embodiment 3 is prepared amplifies the petrographic microscope figure after 100 times；

Fig. 2 is that the skin whitening, moisturizing liquid crystal face cream of embodiment 19 amplifies 100 times of petrographic microscope figure；

Fig. 3 is that the whitening liquid-crystal composition vitro skin that embodiment 20 obtains accumulates H103 resin；

Fig. 4 is the comparison figure that the whitening liquid-crystal composition vitro skin that embodiment 20 obtains accumulates transit dose and hold-up.

Specific implementation mode

The whitening liquid-crystal composition further includes the liquid fatty substance for dissolving whitening active ingredients and LCD vector raw material And water.

It is currently preferred, it is included at least in the whitening active ingredients and promotes excoriation class active material, tyrosine One kind in enzyme inhibitor and inhibition melanosome migration class active material.In the present invention, the whitening active ingredients are preferred Account for whitening liquid-crystal composition raw material gross mass 0.5%~30%, more preferably 10%~20%.

In the present invention, the whitening active ingredients are coated by LCD vector, and the whitening active ingredients of compounding pass through altogether Multiple target point multimachine system synergistic effect is realized in conveying.In the present invention, the total conveying refers to by U.S. of multiple target point multiaction mechanism White active constituent compounding, work.Specifically, the cutin class active material that strips off that the present invention selects acts on cuticula, suppression Melanosome transfer class active material processed acts on basal layer, and antioxidant and anti-sensitizer act on epidermis and skin corium, anti-sugar Change active material and act on skin corium, tyrosinase inhibitor acts on basal layer, and the present invention passes through a variety of different role target spots Whitening active ingredients, altogether conveying in the case of can cooperate with the skin permeation amount for enhancing each whitening active ingredients and loss Amount, significantly increases whitening effect.

In the present invention, the promotion excoriation class active material include but not limited to salicylic acid, Papain and Semen armeniacae amarae.Based on the gross mass of whitening liquid-crystal composition：When whitening active ingredients include promoting excoriation class active material When, it is preferably 0.1%~3% to promote the mass percent of excoriation class active material；More preferably 1%~2%.Promote table Skin falls off substance such as salicylic acid etc., can cutin-softening layer, promote excoriation, the cuticula excessive by peeling off skin, Melanin is taken away from skin, realizes whitening effect.However conventional promotion excoriation class active material need with moisturizing, The sun-proof skin being combined after can ensuring to fall off is stayed pale effect, while skin without stratum corneum is also easy to lead to skin mistake It is quick.The present invention will promote excoriation active material as one of whitening active ingredients, the whitening active with other mechanism of action Substance collective effect, multiple target point whitening effect are more excellent.And LCD vector of the present invention can also provide adequately For moistening effect to simplify whitening step, the good skin sense of LCD vector can also reduce irritation.

In the present invention, the tyrosinase inhibitor includes but not limited to glabridin, Symwhite-337, α-bear In fruit glycosides, ferulic acid and kojic acid.Based on the gross mass of whitening liquid-crystal composition：When whitening active ingredients include tyrosinase When inhibitor, the mass percent of tyrosinase inhibitor is preferably 0.1%~10%；More preferably 1%~5%.Tyrosine Enzyme inhibitor such as glabridin etc. can inhibit the activity of internal tyrosinase, melanin production be prevented, to reduce skin-color Element deposition, effectively removes color spot and freckle.Tyrosinase inhibitor generally requires to penetrate into skin bottom competence exertion its blocking Effect, conventional cosmetic directly add the modes such as tyrosinase inhibitor and are difficult to that it is made effectively to permeate, can not effectively play a role. The LCD vector structure and skin texture that the present invention uses are very much like, can be adsorbed on cuticula, promote whitening active at The effective infiltration divided, to effectively play the whitening function of tyrosinase inhibitor.

In the present invention, the inhibition melanosome migration class active material includes but not limited to niacinamide, heparin sodium.It presses The gross mass meter of whitening liquid-crystal composition：When whitening active ingredients include that melanosome is inhibited to migrate class active material, suppression The mass percent of melanosome migration class active material processed is preferably 0.1%~10%；More preferably 1%~6%.Niacinamide Etc. can act on the melanin generated, transmission of the melanin to horn cell is prevented, pigment deposition is reduced.The present invention adopts LCD vector can promote percutaneous absorption to inhibit melanosome migration class active material, it is made really to be able to contact skin bottom The melanin that layer has been formed, to play more excellent whitening effect.

In the present invention, anti-oxidation active substance includes but not limited to vitamin C and its derivative, vitamin E and its spreads out Biology, polypeptide and hydroxytyrosol.Based on the gross mass of whitening liquid-crystal composition：When whitening active ingredients include anti-oxidant work When property substance, the mass percent of anti-oxidation active substance is preferably 0.1%~5%；More preferably 0.5%~3%.It is anti-oxidant Active material can effectively organize black oxidation process, scavenging activated oxygen, restore the poly- of melanin intermediates and melanin Object is closed, to effectively inhibit the generation of melanin.Antioxidant stability is poor, be added in cosmetics it is apt to deteriorate, point Layer, the present invention load anti-oxidation active substance using LCD vector, are encapsulated in carrier inside, can effectively extend antioxygen Change the holding time of active material, improves overall stability.

In the present invention, the Anti-Inflammatory Actives include but not limited to glycyrrhizic acid hypo acid and Paeonol.By whitening lotion The gross mass meter of crystal composite：When whitening active ingredients include anti-inflammatory activity substance, the quality of anti-inflammatory activity substance Percentage is preferably 0.1%~5%；More preferably 1%~3%.The Anti-Inflammatory Actives such as glycyrrhizic acid hypo acid have stronger anti- Scorching, antiallergic action and skin hormone-like effect, can reduce the biosynthesis of PEG2 in inflammatory tissue, for whitening active The excessively high caused acute inflammation of ingredient local concentration has obvious inhibiting effect.

In the present invention, the anti-saccharogenic activity substance includes but not limited to tea polyphenols, silymarin, phloretin, root skin Glycosides, Quercetin, curcumin and alpha-lipoic acid.Based on the gross mass of whitening liquid-crystal composition：When whitening active ingredients include When anti-saccharogenic activity substance, the mass percent of anti-saccharogenic activity substance is preferably 0.1%~5%；More preferably 0.5%~ 3%.The anti-saccharogenic activity ingredient such as tea polyphenols can promote collagen to generate, and the collagen of skin corium and glycan molecule is prevented to hand over Join, melanin is generated to inhibit tyrosinase to meet sugar activation, it is thin so as to improve the impaired skin of collagen quality, reparation Born of the same parents eliminate blackening, restore elasticity of skin and gloss.

In the present invention, the raw material gross mass of the LCD vector preferably accounts for whitening liquid-crystal composition raw material gross mass 3.5%~35%, more preferably 5.5%~31%, most preferably 8.5%~22%.

In the present invention, according to the gross mass meter of whitening liquid-crystal composition, the mass percent of the liquid crystal emulsifier is excellent It is selected as 1~10%, more preferably 2~8%, most preferably 3~6%.In the present invention, the liquid crystal emulsifier includes but unlimited In polyox-yethylene-polyoxypropylene block copolymer, polyoxyethylene (40) monostearate, -3 methyl distearyl acid of polyglycereol Ester, soybean lecithin, hydrolecithin, cetostearyl alcohol (and) cocoyl glucoside, C14-22 alcohol (and) C12-20 alkyl Portugal Glucosides, cocoyl glucoside (and) lauric alcohol, C22 alcohol alkyl phosphate, cetearyl glucoside, hydroxystearyl alcohol and hydroxyl Stearic glucosides, arachidic alcohol and docosyl alcohol and arachidic alcohol glucoside, docosyl alcohol alkyl phosphate, cetostearyl alcohol and cetearyl Glucoside, cetostearyl alcohol and cocoyl glucoside and myristyl glucoside.

It is further preferred that the liquid crystal emulsifier is the mixture of 2~5 kinds of liquid crystal emulsifiers；More preferably spermaceti is hard Aliphatic radical glucoside, hydroxystearyl alcohol and hydroxy stearate glucosides, arachidic alcohol and docosyl alcohol and arachidic alcohol glucoside, docosyl alcohol alkyl phosphorus The mixture of acid esters and cetostearyl alcohol and cetearyl glucoside.The present invention is for each group in the liquid crystal emulsifier Point ratio is not particularly limited.

In the present invention, the liquid crystal emulsifier plays the main function to form liquid crystal structure, in the liquid that the present invention limits Liquid crystal structure can be formed within the scope of brilliant emulsifier, can not then be formed beyond amount ranges.

In the present invention, based on the gross mass of whitening liquid-crystal composition：The mass percent of the assistant for emulsifying agent is preferably 2 ~25%, more preferably 3~20%, most preferably 5~15%.

In the present invention, the assistant for emulsifying agent includes but not limited to stearyl alcohol, hexylene glycol, polyethylene glycol, propylene glycol, dipropyl Glycol, glycerine, 1,3 butylene glycol and 1,2- pentanediols.Assistant for emulsifying agent of the present invention is preferably the mixed of 2~4 kinds of assistant for emulsifying agents Close object；The assistant for emulsifying agent is more preferably hexylene glycol, propylene glycol, glycerine and 1,3 butylene glycol.The present invention helps emulsification to described Each component ratio in agent is not particularly limited.

In the present invention, the assistant for emulsifying agent can make the interface arrangement of liquid crystal emulsifier more orderly, with more rigidity, The HLB value that liquid crystal emulsifier boundary layer can also be adjusted prevents liquid crystal structure from disappearing to keep liquid crystal structure more stable.

In the present invention, based on the gross mass of whitening liquid-crystal composition：The mass percent of the emulsifing thickener is preferred It is 0.01~5%, more preferably 0.1~3%, most preferably 0.3~1%.

In the present invention, the emulsifing thickener includes but not limited to carbomer, hydroxy ethyl methacrylate, polyacrylamide Amine, polyacrylate -13 (and) polyisobutene (and) polysorbate -20, polyvinylpyrrolidone, hypromellose, Sodium carboxymethylcellulose, sodium acrylate/sodium acryloyldimethyl taurate copolymers (and) isohexadecane (and) polysorbate- 80, guar gum and Arabic gum.Currently preferred, the emulsifing thickener is the mixture of 2~4 kinds of emulsifing thickeners； The mixture is more preferably hydroxy ethyl methacrylate, polyacrylamide, polyvinylpyrrolidone and sodium carboxymethylcellulose. The present invention is not particularly limited each component ratio in the mixture of the emulsifing thickener.

In the present invention, the emulsifing thickener can increase the stability of crystalline emulsion, and it is netted to contribute to form liquid crystal The system of structure, and reduce sensibility of the LCD vector to temperature.

In the present invention, further include former for dissolving whitening active ingredients and LCD vector in the whitening liquid-crystal composition The solvent of material, i.e. liquid fatty substance and water, wherein liquid fatty substance for dissolving water insoluble ingredients, water for dissolve it is water-soluble at Point.

It is currently preferred, according to the gross mass meter of whitening liquid-crystal composition, the mass percent of the water is preferably 5~ 35%, more preferably 10~25%.In the present invention, the water is preferably distilled water.

Currently preferred, according to the gross mass meter of whitening liquid-crystal composition, the mass percent of the liquid fatty substance is excellent It is selected as 2~35%, more preferably 5~30%, most preferably 8~25%.

In the present invention, the liquid fatty substance includes preferably isopropyl myristate, isopropyl palmitate, caprylic capric Glyceride, Miglyol 812N, polyethylene glycol glyceryl laurate ester, polyethylene glycol tristerin, linoleic acid Ester, Sefsol 218, two pungent capric acid propylene glycol esters, pungent capric acid cocoa butter, isononyl isononanoate, glyceryl triacetate, two Methyl-silicone oil, vitamin E, white oil, squalene, sunflower oil and soybean oil.In the present invention, the liquid fatty substance be preferably on State 2~4 kinds of mixtures of liquid fatty substance；More preferably hydroxy ethyl methacrylate, polyacrylamide, polyvinylpyrrolidone and carboxylic The mixture of sodium carboxymethylcellulose pyce.The present invention is not particularly limited each component ratio in above-mentioned liquid fatty substance mixture.

The present invention also provides a kind of preparation methods of whitening liquid-crystal composition described in above-mentioned technical proposal, including following step Suddenly：

Limitation without sequencing between described step A, B and C.

The present invention is divided into water-soluble whitening active ingredients according to the water solubility of whitening active ingredients and water-insoluble whitening is lived Property ingredient, and different solvents is respectively adopted and is dissolved.

The present invention dissolves liquid crystal emulsifier, water-insoluble whitening active ingredients with liquid fatty, obtains oil phase, spare.

Assistant for emulsifying agent and emulsifing thickener with part aqueous solution, are obtained water phase by the present invention, spare.

Water-soluble whitening active ingredients with remainder water dissolution, are obtained whitening active ingredients aqueous solution by the present invention, standby With.

The present invention is not particularly limited the sequence of above three step.

The oil phase that the present invention is prepared is dispersed to micron order after being mixed with water conjunction, you can forms LCD vector, the liquid crystal Water-insoluble whitening active ingredients are enclosed in carrier.Whitening active ingredients aqueous solution is mixed and divided with micrometre level dispersoid It is dissipated to nanoscale, you can also encapsulate water-soluble whitening active ingredients into LCD vector, to obtain U.S. of the present invention White liquor crystal composite.

In the present invention, the micronized processing preferably uses cut mode, it is furthermore preferred that the shear treatment is to micro- The condition of meter level is：5000~15000rpm of shearing rotating speed, preferably 6000~13000rpm；Shear time 1~10min, it is excellent It is selected as 2~5min.

In the present invention, the nanosizing processing is preferably using the side of shearing, the processing of high-pressure homogeneous or high pressure microjet Formula.

When using shear treatment to nanoscale, the shearing rotating speed is preferably 5000~15000rpm, more preferably 6000~10000rpm；The shear time is preferably 1~10min, more preferably 2~8min.

When using high-pressure homogeneous processing to nanoscale, heating temperature is preferably 50~75 DEG C, more preferably 60~70 DEG C； Homogenization pressure is preferably 500~1000bar, more preferably 600~800bar；Homogenization cycles are preferably 1~3 time, more preferably 2 It is secondary.

When using high-speed micro-jet technical finesse to nanoscale, feeding temperature is preferably 50~70 DEG C, more preferably 60 ~65 DEG C；Pressure is preferably 60~160MPa, more preferably 100~120MPa；Homogenization cycles are preferably 1~3 time, more preferably 2 times.

In the present invention, the whitening liquid-crystal composition grain size being prepared using the method for the invention is preferably 100~ 900nm, more preferably 300~700nm.

The present invention also provides application of the whitening liquid-crystal composition in preparing cosmetics described in preceding solution.Specifically , whitening liquid-crystal composition of the present invention is used to prepare the makeup with white-skinned face function, moisture-keeping efficacy, sun-proof function Product.

In the present invention, the form of the cosmetics includes but not limited to face cream, lotion, solidifying frost, Essence, facial mask.

In the present invention, when the whitening liquid-crystal composition is prepared as cosmetics, it is total that whitening liquid-crystal composition accounts for cosmetics The 5~50% of quality, more preferably 10~30%.

In order to further illustrate the present invention, technical solution provided by the invention is retouched in detail with reference to embodiment It states, but they cannot be interpreted as limiting the scope of the present invention.

Embodiment 1

By mass percentage, by 1.0% soybean lecithin, 2.0% cetostearyl alcohol (and) cocoyl glucoside, 4.0% isopropyl palmitate, 2.0% isopropyl myristate and 2% glabridin melt under 70 DEG C of water bath conditions, obtain Oil phase, it is spare；

By 0.1% ferulic acid, 0.1% ursin, 1.0% niacinamide, 0.1%VC and derivative, 1.0% glycyrrhizic acid Acid, 5.0% tea polyphenols are mixed with 30% water, are stirred under 35 DEG C of water bath conditions, are obtained whitening active component solution, standby With；

2.0% polyethylene glycol, 3.0% hexylene glycol and 0.01% hydroxy ethyl methacrylate are dissolved into 46.6% water In, it is stirred under 70 DEG C of water bath conditions, obtains water phase, it is spare；

Water phase is mixed with oil phase, after the completion of mixing, high speed shearing emulsification 5min under conditions of rotating speed is 5500rpm, Obtain micrometre level dispersoid；

Micrometre level dispersoid will be mixed with whitening active component solution, high speed under conditions of rotating speed is 5000rpm Emulsification pretreatment 1min obtains whitening liquid-crystal composition.

Embodiment 2

By mass percentage, by 0.5% hydrolecithin, 0.5% hydroxystearyl alcohol and hydroxy stearate glucosides, 2.0% Miglyol 812N, 2.0% 2 pungent capric acid propylene glycol ester and 1.0%VE are melted under 65 DEG C of water bath conditions, obtain oil Phase, it is spare；

3.0% alpha-arbutin, 3.0% niacinamide, 1.0% Victoria C ethylether, 2.0% silymarin and 35% water are mixed It closes, is stirred under 40 DEG C of water bath conditions, obtain whitening active component solution, it is spare；

By 2.0% stearyl alcohol, 3.0% hexylene glycol, 2.0% and sodium acrylate/sodium acryloyldimethyl taurate copolymers (and) isohexadecane (and) Polyoxyethylene Sorbitan Monooleate and 3.0% carbomer are dissolved into 35% water, under 65 DEG C of water bath conditions Stirring, obtains water phase, spare；

Water phase is mixed with oil phase, after the completion of mixing, high speed shearing emulsification 1min under conditions of rotating speed is 5000rpm, Obtain micrometre level dispersoid；

Micrometre level dispersoid is mixed with whitening active component solution, at temperature 50 C, homogenization pressure 1000bar Matter 1 time, obtains whitening liquid-crystal composition.

Embodiment 3

By mass percentage, by 2.0%C14-22 alcohol (and) C12-20 alkyl glucosides, -3 methyl of 3.0% polyglycereol Glucose distearate, 4.0% pungent capric acid cocoa butter, 6.0% polyethylene glycol glyceryl laurate ester, 4.0% squalene and 1% Symwhite-337 melts under 80 DEG C of water bath conditions, obtains oil phase, spare；

7.0% alpha-arbutin, 6% niacinamide, 0.1% mandelic acid, 5%VC, 3% tea polyphenols are mixed with 20% water, It is stirred under 45 DEG C of water bath conditions, obtains whitening active component solution, it is spare；

1.0% polyethylene glycol, 0.5% sodium carboxymethylcellulose and 0.05% guar gum are dissolved into 38.35% water, It is stirred under 80 DEG C of water bath conditions, obtains water phase, it is spare；

Water phase is mixed with oil phase, after the completion of mixing, high speed shearing emulsification 7min under conditions of rotating speed is 8000rpm, Obtain micrometre level dispersoid；

Micrometre level dispersoid is mixed with whitening active component solution, at 75 DEG C of temperature, homogenization pressure 500bar Matter 5 times.

Embodiment 4

By mass percentage, 3.5% cetearyl glucoside, 5.0% Miglyol 812,2.0% dimension are given birth to Plain E and 5.0% polyethylene glycol tristerin melt under 80 DEG C of water bath conditions, obtain oil phase, spare；

By 4.0% alpha-arbutin, 3.0% niacinamide, 4.0% Victoria C ethylether, 5.0% hydroxytyrosol, 5.0% phloretin It mixes with 23% water, is stirred under 40 DEG C of water bath conditions, obtain whitening active component solution, it is spare；

By 1.0% propylene glycol, 2.0%1,3- butanediols, 0.5% hydroxy ethyl methacrylate and 0.5% polyvinyl pyrrole Alkanone is dissolved into 36.5% water, is stirred under 75 DEG C of water bath conditions, and water phase is obtained, spare；

Water phase is mixed with oil phase, after the completion of mixing, high speed shearing emulsification 3min under conditions of rotating speed is 10000rpm, Obtain micrometre level dispersoid；

Micrometre level dispersoid will be mixed with whitening active component solution, high speed under conditions of rotating speed is 12000rpm Emulsification pretreatment 1min obtains whitening liquid-crystal composition.

Embodiment 5

By mass percentage, by 2.0% myristyl glucoside, 3.0% cetostearyl alcohol and cocoyl glucoside, 1.0% cetostearyl alcohol and cetearyl glucoside, 4.0% Miglyol 812N, 2.0% polyethylene glycol lauric acid are sweet Grease, 1.0% glycyrrhizic acid hypo acid, 4.0% dimethicone and 1.0% glabridin melt under 85 DEG C of water bath conditions, obtain It is spare to oil phase；

10.0% alpha-arbutin, 3.0% niacinamide, 2.0% Quercetin are mixed with 28% water, in 35 DEG C of water bath conditions Lower stirring obtains whitening active component solution, spare；

By 1.0% stearyl alcohol, 3.0% hexylene glycol, 1.5% polyacrylate -13 (and) polyisobutene (and) polysorbate Ester -20 and 0.5% polyvinylpyrrolidone are dissolved into 33% water, are stirred under 85 DEG C of water bath conditions, and water phase is obtained, standby With；

Water phase is mixed with oil phase, after the completion of mixing, high speed shearing emulsification 4min under conditions of rotating speed is 13000rpm, Obtain micrometre level dispersoid；

Micrometre level dispersoid will be mixed with whitening active component solution, high speed under conditions of rotating speed is 11000rpm Emulsification pretreatment 3min obtains whitening liquid-crystal composition.

Embodiment 6

By mass percentage, 3.0% polyox-yethylene-polyoxypropylene block copolymer, 1.0% polyoxyethylene (40) is single Stearate, 1.0% cetearyl glucoside, 4.0% isopropyl palmitate, 3.0% Sefsol 218,4.0% 3 Acetin, 5.0% polyethylene glycol glyceryl laurate ester, 2.0% curcumin and 0.1% glabridin are in 85 DEG C of water-bath items It is melted under part, obtains oil phase, it is spare；

By 1.0% polyethylene glycol, 2.0% dipropylene glycol, 1.5% carbomer, 0.1% Paeonol and 1.5% guar gum It is dissolved into 70.8% water, is stirred under 85 DEG C of water bath conditions, obtain water phase, it is spare；

Water phase is mixed with oil phase, is 50 DEG C, pressure in temperature setting using high-speed micro-jet technology after the completion of mixing Homogeneous 5 times under 160Mpa, obtain whitening liquid-crystal composition.

Embodiment 7

By mass percentage, 2.3% polyoxyethylated 4OE sorbitan monostearates, 3.2% spermaceti is hard Aliphatic radical glucoside, 3% salicylic acid, 2.0% Miglyol 812N and 4.0% isopropyl myristate are in 70 DEG C of water-bath items It is melted under part, obtains oil phase, it is spare；

0.1% alpha-arbutin, 5.0% Victoria C ethylether, 10.0% niacinamide, 0.5% alpha-lipoic acid and 15% water are mixed It closes, is stirred under 45 DEG C of water bath conditions, obtain whitening active component solution, it is spare；

2.0% propylene glycol and 0.1% hydroxy ethyl methacrylate are dissolved into 22.7% water, under 70 DEG C of water bath conditions Stirring, obtains water phase, spare；

Water phase is mixed with oil phase, is 75 DEG C, pressure in temperature setting using high-speed micro-jet technology after the completion of mixing Homogeneous 1 time under 60Mpa, obtains whitening liquid-crystal composition.

Embodiment 8

By mass percentage, by 1.0% arachidic alcohol and docosyl alcohol and arachidic alcohol glucoside, 3.0% myristyl glucose Glycosides, 5.0% pungent isopropyl palmitate, 5.0% Quercetin, 5.0% polyethylene glycol tristerin, the different nonyl of 5.0% isononanoic acid Ester and 3.0% Symwhite-337 melt under 80 DEG C of water bath conditions, obtain oil phase, spare；

8.0% alpha-arbutin, 8.0% niacinamide are mixed with 18% water, is stirred under 55 DEG C of water bath conditions, obtains whitening Active ingredient aqueous solution, it is spare；

3.0% dipropylene glycol, 8.0% glycerine, 3.0% guar gum and 0.2% carbomer are dissolved into 24.8% water, It is stirred under 80 DEG C of water bath conditions, obtains water phase, it is spare；

Water phase is mixed with oil phase, after the completion of mixing, high speed shearing emulsification under conditions of rotating speed is 13000rpm 10min obtains micrometre level dispersoid；

Micrometre level dispersoid is mixed with whitening active component solution, is cut at a high speed under conditions of rotating speed is 12000rpm Emulsification 2min is cut, whitening liquid-crystal composition is obtained.

Embodiment 9

By mass percentage, by 3.0% cetearyl glucoside, 5.0% dimethicone, 5.0% squalene with And 3.0% vitamin E melted under 80 DEG C of water bath conditions, obtain oil phase, it is spare；

5.0% alpha-arbutin, 10.0% niacinamide, 0.1% mandelic acid are mixed with 27% water, in 40 DEG C of water bath conditions Lower stirring obtains whitening active component solution, spare；

By 5.0% glycerine, 10.0%1,3- butanediols, 0.008% sodium acrylate/sodium acryloyldimethyl taurate copolymerization Object (and) isohexadecane (and) Polyoxyethylene Sorbitan Monooleate and 0.002% hypromellose are dissolved into 26.89% water, It is stirred under 80 DEG C of water bath conditions, obtains water phase, it is spare；

Water phase is mixed with oil phase, after the completion of mixing, high speed shearing emulsification 6min under conditions of rotating speed is 14000rpm, Obtain micrometre level dispersoid；

Micrometre level dispersoid is mixed with whitening active component solution, is cut at a high speed under conditions of rotating speed is 13000rpm Emulsification 5min is cut, whitening liquid-crystal composition is obtained.

Embodiment 10

By mass percentage, by 1.0% polyglycereol-3-methyl distearate, 1.0% cocoyl glucoside (and) lauric alcohol, 4.0% hydroxystearyl alcohol and hydroxy stearate glucosides, 5.0% Miglyol 812N, 2.0% vitamin E, 10.0% polyethylene glycol tristerin, 3.0% salicylic acid and 0.5% glabridin melt under 80 DEG C of water bath conditions, Oil phase is obtained, it is spare；

5.0% alpha-arbutin, 8.0% niacinamide, 1.0% tea polyphenols are mixed with 20% water, under 55 DEG C of water bath conditions Stirring, obtains whitening active component solution, spare；

By 5.0% glycerine, 5.0%1,2- pentanediols, 0.25% Arabic gum and 0.25% polyacrylate -13 (and) Polyisobutene (and) polysorbate -20 is dissolved into 29% water, stirred under 80 DEG C of water bath conditions, obtains water phase, it is spare；

Water phase is mixed with oil phase, after the completion of mixing, high speed shearing emulsification 5min under conditions of rotating speed is 12000rpm, Obtain micrometre level dispersoid；

Micrometre level dispersoid is mixed with whitening active component solution, is cut at a high speed under conditions of rotating speed is 12000rpm Emulsification 3min is cut, whitening liquid-crystal composition is obtained.

Embodiment 11

By mass percentage, by 2.0% docosyl alcohol alkyl phosphate, 2.0% cetostearyl alcohol and cetearyl Portugal Between glucosides, 5.0% vitamin E, 2.0% dimethicone, 15.0% white oil, 1.0% glycyrrhizic acid hypo acid and 1.0% phenethyl Benzenediol melts under 75 DEG C of water bath conditions, obtains oil phase, spare；

8.0% alpha-arbutin, 10.0% niacinamide, 2.0%VC are mixed with 24% water, stirred under 60 DEG C of water bath conditions It mixes, obtains whitening active component solution, it is spare；

5.0% glycerine, 0.25% sodium carboxymethylcellulose and 0.25% polyacrylamide are dissolved into 22.5% water, It is stirred under 75 DEG C of water bath conditions, obtains water phase, it is spare；

Water phase is mixed with oil phase, after the completion of mixing, high speed shearing emulsification 6min under conditions of rotating speed is 13000rpm, Obtain micrometre level dispersoid；

Micrometre level dispersoid is mixed with whitening active component solution, is cut at a high speed under conditions of rotating speed is 11000rpm Emulsification 2min is cut, whitening liquid-crystal composition is obtained.

Embodiment 12

By mass percentage, by 0.5% docosyl alcohol alkyl phosphate, 2.5% arachidic alcohol and docosyl alcohol and arachidic alcohol Portugal Glucosides, 4.0% sunflower oil, 5.0% white oil, 1.0% Victoria C ethylether and 8.0% glabridin are under 80 DEG C of water bath conditions Melting, obtains oil phase, spare；

10.0% alpha-arbutin, 3.0% niacinamide, 1% Paeonol, 2% hydroxytyrosol are mixed with 21% water, at 55 DEG C It is stirred under water bath condition, obtains whitening active component solution, it is spare；

By 2.0% hexylene glycol, 6.0%1,3- butanediols, 1.0%C22 alcohol alkyl phosphate, 0.2% Arabic gum and 0.2% hydroxy ethyl methacrylate is dissolved into 32.6% water, is stirred under 80 DEG C of water bath conditions, and water phase is obtained, spare；

Water phase is mixed with oil phase, after the completion of mixing, high speed shearing emulsification 5min under conditions of rotating speed is 14000rpm, Obtain micrometre level dispersoid；

Micrometre level dispersoid is mixed with whitening active component solution, is cut at a high speed under conditions of rotating speed is 12000rpm Emulsification 6min is cut, whitening liquid-crystal composition is obtained.

Embodiment 13

By mass percentage, by 2.5% hydroxystearyl alcohol and hydroxy stearate glucosides, 1.5% docosyl alcohol alkyl phosphate, 4.0% soybean oil, 3.0% polyethylene glycol tristerin, 2.0% phloretin, 5.0% white oil and 2.0% salicylic acid exist It is melted under 75 DEG C of water bath conditions, obtains oil phase, it is spare；

9.0% niacinamide, 6.0% Victoria C ethylether are mixed with 22% water, is stirred under 40 DEG C of water bath conditions, obtains U.S. White active ingredient aqueous solution, it is spare；

By 7.0% glycerine, 4.0% propylene glycol, 0.5% polyacrylate -13 (and) polyisobutene (and) polysorbate - 20 and 1.5% hypromellose be dissolved into 30% water, stirred under 75 DEG C of water bath conditions, obtain water phase, it is spare；

Water phase is mixed with oil phase, after the completion of mixing, high speed shearing emulsification 3min under conditions of rotating speed is 13000rpm, Obtain micrometre level dispersoid；

Micrometre level dispersoid is mixed with whitening active component solution, is cut at a high speed under conditions of rotating speed is 10000rpm Emulsification 1min is cut, whitening liquid-crystal composition is obtained.

Embodiment 14

By mass percentage, by 5.0% polyglycereol-3-methyl distearate, 3.0% docosyl alcohol alkyl phosphoric acid Ester and cetostearyl alcohol and cetearyl glucoside, 2.0% cetostearyl alcohol and cetearyl glucoside, 5.0% octanoic acid Glycerol decanoate, 5.0% polyethylene glycol tristerin, 2.0% mandelic acid, 5.0% silymarin and 5.0% white oil It is melted under 75 DEG C of water bath conditions, obtains oil phase, it is spare；

2.0% alpha-arbutin, 5.0% niacinamide, 0.1% Victoria C ethylether are mixed with 20% water, in 35 DEG C of water-bath items It is stirred under part, obtains whitening active component solution, it is spare；

7.0% hexylene glycol, 12.0% glycerine, 0.5% polyacrylamide and 0.2% hypromellose are dissolved into It in 21.2% water, is stirred under 80 DEG C of water bath conditions, obtains water phase, it is spare；

Water phase is mixed with oil phase, after the completion of mixing, high speed shearing emulsification 8min under conditions of rotating speed is 14000rpm, Obtain micrometre level dispersoid；

Micrometre level dispersoid is mixed with whitening active component solution, is cut at a high speed under conditions of rotating speed is 13000rpm Emulsification 4min is cut, whitening liquid-crystal composition is obtained.

Embodiment 15

By mass percentage, by 1.0% hydroxystearyl alcohol and hydroxy stearate glucosides, 5.0% cetostearyl alcohol and cocounut oil Base glucoside, 8.0% Miglyol 812,8.0% glyceryl linoleate, 8.0% white oil, 8.0% Caprylic Capric three Ester, 3.0% vitamin E, 0.5% glabridin, 0.5% salicylic acid and 1.5% Symwhite-337 are in 85 DEG C of water-bath items It is melted under part, obtains oil phase, it is spare；

3.0% alpha-arbutin, 3.0% niacinamide are mixed with 17% water, is stirred under 55 DEG C of water bath conditions, obtains whitening Active ingredient aqueous solution, it is spare；

By 3.0% dipropylene glycol, 8.0% glycerine, 2.0% Paeonol, 1.0% tea polyphenols, 3.0% guar gum and 0.2% carbomer is dissolved into 24.3% water, is stirred under 80 DEG C of water bath conditions, and water phase is obtained, spare；

Water phase is mixed with oil phase, after the completion of mixing, high speed shearing emulsification under conditions of rotating speed is 15000rpm 10min obtains micrometre level dispersoid；

Micrometre level dispersoid is mixed with whitening active component solution, is cut at a high speed under conditions of rotating speed is 14000rpm Emulsification 3min is cut, whitening liquid-crystal composition is obtained.

Embodiment 16

By mass percentage, by 1.0% cocoyl glucoside (and) lauric alcohol, 3.0% hydroxystearyl alcohol and hydroxyl it is hard Lipolysaccharide glycosides, 5.0% soybean lecithin, 5.0% isononyl isononanoate and 4.0% sunflower oil melt under 90 DEG C of water bath conditions Melt, obtains oil phase, it is spare；

10.0% alpha-arbutin, 4.0% niacinamide are mixed with 22% water, is stirred under 55 DEG C of water bath conditions, obtains U.S. White active ingredient aqueous solution, it is spare；

By 10.0% stearyl alcohol, 3.0% dipropylene glycol, 12.0% glycerine, 0.2% polyacrylamide and 0.2% poly- second Alkene pyrrolidone is dissolved into 20.6% water, is stirred under 90 DEG C of water bath conditions, and water phase is obtained, spare；

Water phase is mixed with oil phase, after the completion of mixing, high speed shearing emulsification 6min under conditions of rotating speed is 15000rpm, Obtain micrometre level dispersoid；

Micrometre level dispersoid is mixed with whitening active component solution, is cut at a high speed under conditions of rotating speed is 15000rpm Emulsification 6min is cut, whitening liquid-crystal composition is obtained.

Embodiment 17

By mass percentage, by 6.0% arachidic alcohol and docosyl alcohol and arachidic alcohol glucoside, 10.0% pungent capric acid cocoa butter And 10.0% squalene melted under 85 DEG C of water bath conditions, obtain oil phase, it is spare；

5% alpha-arbutin, 5.0% niacinamide are mixed with 24% water, is stirred under 30 DEG C of water bath conditions, obtains whitening Active ingredient aqueous solution, it is spare；

5.0% glycerine, 12.0% stearyl alcohol, 0.5% polyacrylamide and 0.5% polyvinylpyrrolidone are dissolved into It in 22% water, is stirred under 85 DEG C of water bath conditions, obtains water phase, it is spare；

Water phase is mixed with oil phase, after the completion of mixing, high speed shearing emulsification under conditions of rotating speed is 14000rpm 10min obtains micrometre level dispersoid；

Micrometre level dispersoid is mixed with whitening active component solution, is cut at a high speed under conditions of rotating speed is 12000rpm Emulsification 7min is cut, whitening liquid-crystal composition is obtained.

Embodiment 18

By whitening liquid-crystal composition be respectively placed in 45 DEG C, 4 DEG C, illumination, room temperature and it is multiple melt under the conditions of investigate stability, respectively In its liquid crystal stable appearance of polarized light microscope observing when 1 week, 3 weeks, 5 weeks, 7 weeks and 9 weeks.Table 1 be 45 DEG C, 4 DEG C, illumination, Room temperature and it is multiple melt under the conditions of whitening liquid-crystal composition stability general performance：

The stability of 1 whitening liquid-crystal composition of table

As shown in Figure 1, the whitening liquid-crystal composition to be shot when stability test amplifies the petrographic microscope after 100 times Figure, when study on the stability, whitening liquid-crystal composition place 1 week, 3 weeks, 5 weeks, 7 weeks and 9 weeks after liquid crystal number with Fig. 1 phases Together, do not occur significant change.

Stability test the result shows that：Whitening liquid-crystal composition provided by the invention 45 DEG C, 4 DEG C, illumination, room temperature and multiple Under the conditions of melting, without layering, precipitation phenomenon after investigating 1 week, 3 weeks, 5 weeks, 7 weeks and 9 weeks.Liquid crystal observes number under petrographic microscope More and size is uniform, meet application request (3 months stable products are placed at 45 DEG C, in cosmetic field it is believed that It is stable to place 3 years at normal temperatures).Especially composition is still relatively stablized containing higher whitening active ingredients, Therefore, whitening liquid-crystal composition provided by the invention is with good stability.

19 skin whitening, moisturizing liquid crystal face cream of embodiment

By mass percentage, firmly by 2.0%PEC-10 dimethyl silicone polymers, 1.0% sucrose stearate, 1.0% Lipidol, 4.5% glycerin monostearate, 1.0% cetostearyl alcohol, 3.0% jojoba oil melt in 75 DEG C of water-baths, obtain oil Phase；

By 5.0% glycerine, 5.0% propylene glycol, 0.3% triethanolamine, 0.2% carbomer 2020 and 77.0% purified water in It is dissolved in 75 DEG C of water-baths, obtains water phase；Oil phase and water phase are stirred, and emulsified to get common cream.

The whitening liquid-crystal composition of common cream and embodiment 3 is pressed 1:1 mix mass fraction be 50.0% whitening lotion The face cream of crystal composite, wherein containing 3.5% alpha-arbutin of mass percent, 3% niacinamide, 0.05% phenethyl isophthalic two Phenol, 2.5%VC and 0.05% mandelic acid, whitening active object total content are 9.55%.

The skin whitening, moisturizing liquid crystal face cream being prepared is amplified 100 times under petrographic microscope, is obtained as shown in Figure 2 inclined Light microscope figure, as shown in Fig. 2, the liquid crystal size of skin whitening, moisturizing liquid crystal face cream is uniform, active ingredient is covered by liquid crystal structure In.

Comparative example 1

By mass percentage, by 0.05% Symwhite-337,2.0%PEC-10 dimethyl silicone polymers, 1.0% Sucrose stearate, 1.0% stearyl alcohol, 4.5% glycerin monostearate, 1.0% cetostearyl alcohol and 3.0% jojoba oil It is melted in 75 DEG C of water-baths, obtains oil phase；

By 3.5% alpha-arbutin, 3% niacinamide, 0.05% mandelic acid, 2.5%VC, 5.0% glycerine, 5.0% the third two Alcohol, 0.3% triethanolamine, 0.2% carbomer 2020 and 67.9% water mixing, stir, obtain under 45 DEG C of water bath conditions Whitening active component solution, it is spare；

Oil phase and water phase are stirred, and emulsified to get basic components face cream, wherein containing mass percent 3.5% Alpha-arbutin, 3% niacinamide, 0.05% Symwhite-337,2.5%VC and 0.05% mandelic acid, whitening active Object total content is 9.1%.

The basic components face cream that comparative example 1 is prepared is identical as the whitening active ingredients content of embodiment 19, and difference exists In whitening active ingredients are not coated with liquid crystal structure.

Comparative example 2 is free of the O/W emulsion of liquid crystal structure

By mass percentage, by 2.0% vitamin E, 4.0% alpha-arbutin, 3.0% niacinamide, 4.0% Victoria C ethyl Ether, 5.0% hydroxytyrosol, 5.0% phloretin, 3.0% stearic acid, 4.5% glycerin monostearate, 5.0% cetostearyl alcohol And 6.0% dimethyl silicone polymer melted in 75 DEG C of water-baths, obtain oil phase；

10.0% glycerine, 5.0% propylene glycol, 0.3% triethanolamine and 63.2% purified water is molten in 75 DEG C of water-baths Solution obtains the O/W emulsion without liquid crystal structure, i.e. control group composite whitening composition.

The whitening active ingredients content of comparative example 2 is identical with whitening liquid-crystal composition prepared by embodiment 4, difference lies in The whitening active ingredients of comparative example 2 are coated with O/W structures, and embodiment 4 is then coated with liquid crystal structure.

Embodiment 20

This experiment is absorbed to the skin of whitening liquid-crystal composition and through performance is verified.

Percutaneous penetration selects improved Franz diffusion cells, with weight for 160~220g male SD rat skin of abdomen For model.Diffusion cell parameter is：Effective diffusion area 3.14cm², pool volume 7.0mL is received, receiving liquid is physiological saline, magnetic force Mixing speed is 200rpm.

The rat abdomen skin of intact unbroken is fixed between reception tank and supply pool to (skin inner layer is towards reception Pond)；Acceptance pool keeps 37.0 ± 0.5 DEG C of constant temperature, respectively at 1h, 2h, 4h, 6h, 8h, 10h, draws receiving liquid 0.35mL for 24 hours, and Supplement release test substance 0.35mL, receiving liquid use 0.22 μm of organic membrane filtration.

By whitening liquid-crystal composition prepared by embodiment 2,4,5,12 and 15 and compound U.S. of control group prepared by comparative example 2 White composition carries out penetrating absorption, test result is shown in Fig. 3 and Fig. 4 according to the method described above as test substance.

Because 2,4,5,12 and 15 containing 3% niacinamide, using high-efficient liquid phase color in whitening liquid-crystal composition embodiment Spectrum measures the concentration of niacinamide in receiving liquid, calculates the accumulation transdermal penetration amount at each time point, draw transdermal absorpting medicine-when it is bent Line understands the transdermal test in vitro osmotic effect of niacinamide.

Niacinamide unit area is calculated as follows accumulates transdermal amount：

Wherein：Q_sTo accumulate transdermal amount；S is effective diffusion area；V is physiological saline volume in reception tank；C_iIt is the 1st time To receiving liquid drug concentration when previous sample；N is n-th sample volume；Receiving liquid drug concentration when Cn is the sub-sampling.

As seen from Figure 3, the Percutaneous permeability for 24 hours of embodiment 2,4,5,12 and 15 is respectively 227.58 μ g/cm²、 292.57μg/cm²、379.53μg/cm²、327.54μg/cm²、424.54μg/cm²；The Percutaneous permeability for 24 hours of comparative example 2 is 1841.98μg/cm².This shows that the skin cumulative transit dose for the control group composite whitening composition that comparative example 2 obtains is all apparent Higher than the skin cumulative transit dose of embodiment 2,4,5,12 and 15 samples.Active principle infiltration capacity is excessively high to be easy to cause skin thorn Swash, allergy, and active principle is lost in soon, whitening liquid-crystal composition provided by the invention has good slow releasing function, can By the whitening active ingredients slow release of high concentration, stimulation is reduced, is administered continuously, to improve whitening effect.

24 hours hold-ups of whitening liquid-crystal composition that the embodiment of the present invention 2,4,5,12 and 15 obtains are respectively 285.4 μ g/cm²、191.2μg/cm²、247.0μg/cm²、273.8μg/cm², and control group composite whitening composition prepared by comparative example 2 24 hours hold-ups be only 18.01 μ g/cm².This show comparative example 2 prepare control group composite whitening composition relative to The skin hold-up of whitening liquid-crystal composition is low, can not play long-acting whitening function, whitening liquid-crystal composition provided by the invention The skin hold-up that active principle can be improved, to provide significantly more whitening effect.

To sum up, whitening liquid-crystal composition of the invention has low transdermal amount and high hold-up, and skin effect is excellent, Has the advantages that long-acting whitening.

Embodiment 21

The water lock performance of whitening liquid-crystal composition of the present invention is verified in this experiment.

The structure and skin that liquid crystal structure can be formed as true Stratum corneum lipids have higher compatibility, There is effect as lipid between corneocyte.Due to its unique double-layer structure, the cuticula of skin can be adsorbed in It forms protective layer and there is moisture-keeping function.

1. the measurement and moisture loss of keratoderma moisture measure

Experimental method：Select skin health, without cosmetic allergic contact dermatitis history, the volunteer of 20~one's mid-30s of age 24, 25 ± 1 DEG C of indoor temperature；It is detected in the environment of humidity 50% ± 5%.When experiment using inboard arm portion 4cm × 4cm skins as Test zone smears corresponding product 0.5g.

Volunteer is randomly divided into two groups, every group of 12 people, one group is test group, smears skin whitening, moisturizing prepared by embodiment 19 Liquid crystal face cream, one group is control group, smears basic components face cream prepared by comparative example 2.

It measures：It is tested after 4cm × 4cm test zones of inboard arm, product 15min to be applied：

(1) inboard arm moisture content of skin is measured with skin moisture detector.Using corresponding product 0h, 0.5h, 1h, After 2h, 4h, 6h, test arm inside skin water content is measured 3 times, is averaged respectively.

(2) using percutaneous moisture loss measuring instrument measure moisture of skin scatter and disappear value, using corresponding product 0h, 0.5h, 1h, After 2h, 4h, 6h, test arm inside skin windage is measured 3 times, is averaged respectively.

Experimental result：

(1) measurement of keratoderma moisture

It is measured by moisture of skin tester and weighs cuticula using the variation of keratoderma capacitance before and after product The variation of water content, to be currently used evaluation method the moisture-keeping efficacy of evaluating cosmetics.The present invention adds whitening lotion Influence of the face cream of crystal composite to skin moisture content is as shown in table 2.

2 moisture test value (%) of table

Group	0h	0.5h	1h	2h	4h	6h
							Test group	57.43	50.24	44.69	44.23	43.73	43.13
Control group	54.12	40.27	36.94	30.21	27.12	28.43

As can be seen from Table 2, compared with the control group, the moisture of face cream of the test group smearing containing whitening liquid-crystal composition contains There are significant difference (p for amount<0.05), that is, show that the face cream moistening effect containing whitening liquid-crystal composition of the present invention is notable, Moisture preserving time is higher than basic components face cream.

(2) measurement that moisture percutaneously scatters and disappears

Moisture of skin windage can characterize the water lock function of cosmetics, and value is smaller, and moisture loss is fewer, water lock function It is stronger, conversely, water lock ability is weaker.Moisture loss value is measured using skin water loss tester, the results are shown in Table 3.

3 moisture loss value (%) of table

Group	0h	0.5h	1h	2h	4h	6h
							Test group	12.44	10.42	8.97	9.56	10.12	10.54
Control group	13.72	14.07	14.84	14.12	13.98	13.27

As can be seen from Table 3, compared with the control group, after test group has smeared the face cream containing whitening liquid-crystal composition, 2 (the p that scatters and disappears of moisture of skin is effectively reduced in~6h<0.05), show that the face cream containing whitening liquid-crystal composition has preferable water lock Effect, and the water lock time is long.

Comparative example 3

By 9.5% alpha-arbutin, 5.0% glycerine, 5.0% propylene glycol, 0.3% triethanolamine, 0.2% carbomer 2020 with 67.5% water mixing, stirs under 45 DEG C of water bath conditions, obtains whitening active component solution, spare；

Oil phase and water phase are stirred, and emulsified to get alpha-arbutin face cream, wherein containing quality percentage is wherein contained The whitening active object of several 9.5% alpha-arbutins.

Comparative example 4

In addition to 9.5% alpha-arbutin in comparative example 3 is replaced with 9.5% niacinamide, other steps with 3 phase of comparative example Together, niacinamide face cream is obtained.

Comparative example 5

In addition to 9.5% alpha-arbutin in comparative example 3 is replaced with 9.5%VC, other steps are identical as comparative example 3, Obtain VC face creams.

Comparative example 6

By mass percentage, by 9.5% Symwhite-337,2.0%PEC-10 dimethyl silicone polymers, 1.0% Sucrose stearate, 1.0% stearyl alcohol, 4.5% glycerin monostearate, 1.0% cetostearyl alcohol, 3.0% jojoba oil in It is melted in 75 DEG C of water-baths, obtains oil phase；

5.0% glycerine, 5.0% propylene glycol, 0.3% triethanolamine, 0.2% carbomer 2020 and 67.5% water are mixed It closes, is stirred under 45 DEG C of water bath conditions, obtain whitening active component solution, it is spare；

Oil phase and water phase are stirred, and emulsified to get Symwhite-337 face cream, wherein containing matter is wherein contained Measure the whitening active object of 9.5% alpha-arbutin of percentage.

Embodiment 22

The whitening efficiency of whitening active ingredients can be improved to further illustrate the present invention the whitening liquid-crystal composition, is selected Skin image analyzer Mexameter MX 16 carry out efficacy test to sample.

By choosing 30 volunteers, 20~one's mid-30s of age, color spot clinical scale is in 3 grades or more, position on probation Two cheekbone of face, before experiment and continuous use product is after 4 weeks and 8 weeks, is acquired by same person Mexameter MX 16 The dermal melanin content MI values of same test zone.

Volunteer is randomly divided into 6 groups, every group of 5 people are respectively：

Test group：Smear skin whitening, moisturizing liquid crystal face cream prepared by embodiment 19；

Control group：Smear basic components face cream prepared by comparative example 1；

9.5% α-ursolic acid face cream groups：Smear α-ursolic acid face cream prepared by comparative example 3；

9.5% niacinamide face cream group：Smear niacinamide face cream prepared by comparative example 4；

9.5%VC face cream groups：Smear VC face creams prepared by comparative example 5；

9.5% Symwhite-337 face cream group：Smear Symwhite-337 face cream prepared by comparative example 6.

The test result of each group is as shown in table 4：

The comparison of 4 different time skin color bright values of table

As can be seen from Table 4, under the premise of whitening active object gross mass is identical, contain whitening liquid crystal group of the present invention The face cream effect for closing object is apparently higher than control group, is also apparently higher than 9.5% alpha-arbutin face cream group, 9.5% phenethyl isophthalic two Phenol face cream group, 9.5% niacinamide face cream group and 9.5%VC face cream groups show the whitening active composition group for acting on different target spots It is combined with synergistic function, and liquid crystal structure can increase the Transdermal absorption of whitening active ingredients, is allowed to faster permeate To skin deep layer, enhance white-skinned face function.

By the above test result it is found that whitening liquid-crystal composition provided by the present invention can be good at being applied to cosmetics In field, and due to its unique liquid crystal structure, i.e., plays the role of stablizing to active ingredient, be sustained, also improve product pair Human skin whitening and moisture-keeping function.

The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also answered It is considered as protection scope of the present invention.

Claims

1. a kind of whitening liquid-crystal composition, raw material include whitening active ingredients and LCD vector；

The whitening active ingredients include promoting excoriation class active material, tyrosinase inhibitor, melanosome being inhibited to move Move at least two in class active material, anti-oxidation active substance, anti-inflammatory activity substance and anti-saccharogenic activity substance；

The whitening liquid-crystal composition further include for dissolve the liquid fatty substance of whitening active ingredients and/or LCD vector raw material and Water.

2. whitening liquid-crystal composition according to claim 1, which is characterized in that press the gross mass of whitening liquid-crystal composition Meter：

When whitening active ingredients include promoting excoriation class active material, excoriation class active material is promoted to account for whitening The 0.1%~3% of the gross mass of liquid-crystal composition；

When whitening active ingredients include tyrosinase inhibitor, tyrosinase inhibitor accounts for total matter of whitening liquid-crystal composition The 0.1%~10% of amount；

When whitening active ingredients include that melanosome is inhibited to migrate class active material, melanosome is inhibited to migrate class active matter Matter accounts for the 0.1%~10% of the gross mass of whitening liquid-crystal composition；

When whitening active ingredients include anti-oxidation active substance, anti-oxidation active substance accounts for total matter of whitening liquid-crystal composition The 0.1%~5% of amount；

When whitening active ingredients include anti-inflammatory activity substance, anti-inflammatory activity substance accounts for total matter of whitening liquid-crystal composition The 0.1%~5% of amount；

When whitening active ingredients include anti-saccharogenic activity substance, anti-saccharogenic activity substance accounts for total matter of whitening liquid-crystal composition The 0.1%~5% of amount.

3. whitening liquid-crystal composition according to claim 1, which is characterized in that press the gross mass of whitening liquid-crystal composition Meter：

The material quality percentage of the LCD vector is：Liquid crystal emulsifier 1~10%, assistant for emulsifying agent 2~25% and emulsification Thickener 0.01~5%.

4. whitening liquid-crystal composition according to claim 1, which is characterized in that according to the gross mass of whitening liquid-crystal composition Meter, the liquid fatty substance account for the 2%~35% of the gross mass of whitening liquid-crystal composition, and the water accounts for the total of whitening liquid-crystal composition The 5%~35% of quality.

5. the whitening liquid-crystal composition according to Claims 1 to 4 any one, which is characterized in that

The promotion excoriation class active material is one or more in salicylic acid, Papain and semen armeniacae amarae；

The tyrosinase inhibitor is in glabridin, Symwhite-337, alpha-arbutin, ferulic acid and kojic acid It is one or more；

The anti-oxidation active substance is selected from vitamin C and its derivative, vitamin E and its derivative, polypeptide and hydroxyl junket It is one or more in alcohol；

The anti-saccharogenic activity substance is selected from tea polyphenols, silymarin, phloretin, phloridzin, Quercetin, curcumin and α-sulphur It is one or more in octanoic acid.

6. the whitening liquid-crystal composition according to Claims 1 to 4 any one, which is characterized in that

The liquid crystal emulsifier is selected from polyox-yethylene-polyoxypropylene block copolymer, polyoxyethylene (40) monostearate, poly- sweet Oily -3 methyl distearates, soybean lecithin, hydrolecithin, cetostearyl alcohol (and) cocoyl glucoside, C14- 22 alcohol (and) C12-20 alkyl glucosides, cocoyl glucoside (and) lauric alcohol, C22 alcohol alkyl phosphate, cetearyl Portugal Glucosides, hydroxystearyl alcohol and hydroxy stearate glucosides, arachidic alcohol and docosyl alcohol and arachidic alcohol glucoside, docosyl alcohol alkyl phosphate, One in cetostearyl alcohol and cetearyl glucoside, cetostearyl alcohol and cocoyl glucoside and myristyl glucoside Kind is a variety of；

The assistant for emulsifying agent be selected from stearyl alcohol, hexylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, glycerine, 1,3 butylene glycol with And it is one or more in 1,2- pentanediols；

The emulsifing thickener be selected from carbomer, hydroxy ethyl methacrylate, polyacrylamide, polyacrylate -13 (and) it is poly- different Butylene (and) polysorbate -20, polyvinylpyrrolidone, hypromellose, sodium carboxymethylcellulose, sodium acrylate/ In sodium acryloyldimethyl taurate copolymers (and) isohexadecane (and) Polyoxyethylene Sorbitan Monooleate, guar gum and Arabic gum It is one or more.

7. the whitening liquid-crystal composition according to Claims 1 to 4 any one, which is characterized in that the liquid fatty substance choosing From isopropyl myristate, isopropyl palmitate, Miglyol 812, Miglyol 812N, polyethylene glycol lauric acid Glyceride, polyethylene glycol tristerin, glyceryl linoleate, Sefsol 218, two pungent capric acid propylene glycol esters, the pungent last of the ten Heavenly stems Sour cocoa butter, isononyl isononanoate, glyceryl triacetate, dimethicone, vitamin E, white oil, squalene, sunflower oil with And it is one or more in soybean oil.

8. the preparation method of the whitening liquid-crystal composition described in claim 1~7 any one, includes the following steps：

D, the water phase mixing and emulsifying for obtaining the oil phase that step A is obtained with step B, micronized processing obtain micrometre level dispersoid；

E, the micrometre level dispersoid mixing and emulsifying for obtaining the whitening active ingredients aqueous solution that step C is obtained with step D, nanosizing Processing, obtains whitening liquid-crystal composition；

Limitation without sequencing between described step A, B and C.

9. the preparation method of whitening liquid-crystal composition according to claim 8, which is characterized in that micronized in the step D Processing is shear treatment to micron order；

10. application of the whitening liquid-crystal composition in preparing cosmetics described in claim 1~7 any one.