CN108354993A - A kind of Chinese medicine composition for treating depression - Google Patents
A kind of Chinese medicine composition for treating depression Download PDFInfo
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- CN108354993A CN108354993A CN201810441561.3A CN201810441561A CN108354993A CN 108354993 A CN108354993 A CN 108354993A CN 201810441561 A CN201810441561 A CN 201810441561A CN 108354993 A CN108354993 A CN 108354993A
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- A61K36/18—Magnoliophyta (angiosperms)
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Abstract
The invention discloses a kind of Chinese medicine compositions for treating depression.It is made of the raw material of following parts by weight：30 50 parts of radix bupleuri, 20 40 parts of Radix Polygalae, 20 30 parts of Radix Paeoniae Alba, 3 10 parts of Fructus Aurantii, 10 20 parts of Radix Glycyrrhizae.The Chinese medicine composition for the treatment of depression prepared by the present invention; there is good therapeutic effect for depression; applied widely suitable for depression caused by many reasons, Chinese medicine composition of the invention can do piece agent; aqua; disintegrant, the pharmaceutically acceptable dosage form such as plaster, preparation method are simple; raw material sources are wide, are suitble to scale industrial production.
Description
Technical field
The invention belongs to field of medical technology, and in particular to a kind of Chinese medicine composition for treating depression.
Background technology
Depression is to endanger the common frdquently encountered disease of human physical and mental health.National the minimum of depression illness rate is estimated as 2%,
There are 30,000,000 patients with depression, and discriminates against and ignore as hindering the two for the treatment of depression to hinder greatly.And at those with height
In the old men of diseases such as blood pressure, coronary heart disease, diabetes even cancer, incidence of depression is more up to 50%.Depression at
For the common disease of ours at one's side, frequently-occurring disease, and serious patients with depression often results in introgression, the system caused therefrom
Row family and social concern and economic loss will be huge and can not retrieve.
Preceding depression type is various, according to depression reason difference can be divided into primary and secondary depression or
Reactivity and endogenous depression；It can be divided into neurosis and psychotic depression according to the performance difference of depressive symptom；
It can be divided into child depression, climacteric depression and patients with senile depression according to disease time difference.Meanwhile clinically to suppression
The diagnosis of strongly fragrant disease is often subdivided into mild depression, Serious depression, acute depression and chronic suppression according to symptom weight, morbidity are suddenly slow again
It is strongly fragrant.
Currently, antidepressant generally uses Western medicine, such as antidepressant based on monoamine hypothesis：Monoamine oxidase inhibits
Agent, imipramine, Paxil, Prozac, escitalopram；Antidepressant based on hpa axis dysfunction：
Antalarmin, R121919, desipramine；Antidepressant based on amino acid, peptides：Lamotrigine, Eliprodil；On
It is definite to state antidepression Western medicine curative effect of medication, but that there is also toxic side effects simultaneously is big, easy tos produce pharmacological dependence, the state of an illness easily repeatedly etc.
Problem.
Therefore, the antidepressant development based on natural Chinese medicinal herb and exploitation cause the highest attention of people.Patent
201710438876.8 disclose a kind of Chinese medicine for treating pregnant depression, are made of the bulk pharmaceutical chemicals of following weight：Umbrella is spent
10-15 parts of thin,tough silk hair chrysanthemum, 5-15 parts of leopard mushroom, leading 10-15 parts of grass, 20-30 parts of rabbit hair wormwood artemisia, cypress 10-15 parts of seabed, day lily
15-30 parts of 30-60 parts of, Hong le hooks, 8-15 parts of hindu lotus leaf-base, 6-15 parts of hourglass reed, 3-8 parts of Radix Glycyrrhizaes.Patent 201710700771.5
A kind of Chinese medicine for treating Ischemic Stroke retarded depression is disclosed, which exempts from pan-fried particle by the drug of following weight meter and be made：
Radix Astragali 15-25g, Radix Angelicae Sinensis 10-15g, Rhizoma Chuanxiong 9-12g, rhizoma cyperi 10-15g, grass-leaved sweetflag 10-15g, tuber of pinellia 9-12g, fushen 15-
20g, Radix Curcumae 15-20g, rhizoma atractylodis 9-12g, cape jasmine 9-12g, Divine Comedy 15-20g and amber 4-6g, by above-mentioned granule mixing, i.e.,
.The drug specificity of above-mentioned treatment depression is strong, cannot treat common patients with depression, and cure rate is relatively low, drug administration
Period is long, slowly effect.
Invention content
The purpose of the present invention is to provide a kind of Chinese medicine compositions for treating depression.
A kind of Chinese medicine composition for treating depression, is made of the raw material of following parts by weight：30-50 parts of radix bupleuri, Radix Polygalae
20-40 parts, 20-30 parts of Radix Paeoniae Alba, 3-10 parts of Fructus Aurantii, 10-20 parts of Radix Glycyrrhizae.
The Chinese medicine composition further includes moist 3-8 parts of orchid (Cymbidium madidum Lindley).
The Chinese medicine composition further includes soft cucurbit 3-8 parts.(Lagenaria mollis)
The preparation method of the Chinese medicine composition of above-mentioned treatment depression, carries out in accordance with the following steps：
(1) according to parts by weight, 30-50 parts of radix bupleuri, 20-40 parts of Radix Polygalae, 20-30 parts of Radix Paeoniae Alba is taken to add 6-12 times of parts by weight
Several water impregnates, and impregnates 1-3 hours, is placed in decoction container and decocts 1-3 hours, obtains decoction liquor；
(2) 3-10 parts of Fructus Aurantii is taken, it is coarse powder to beat, and is placed in distillation container, adds the water of 3-8 times of parts by weight, infiltrates 0.5-2
Hour；Boiling is quickly heated up to, 10-40min, connection reflux condensing tube is kept to collect condensate liquid, obtain distillate；
(3) it extracting liquorice 10-20 parts, crushes, crosses 40-60 mesh sieve, water-swellable 16-32 hours of 1-3 times of parts by weight are added,
Stirring, with filtered through gauze, filtrate adds the clarified solution of 3-5 times of parts by weight, and stirring stands 20-30min；Filtering, is filtered
Liquid；
(4) by decoction liquor, distillate, filtered fluid merges, and decompression low temperature is evaporated the Chinese medicine composition that treatment depression is made.
The gauze is double gauze.
The clarified solution is 1% chitosan solution；The preparation method of the chitosan solution is：Chitosan 1g is weighed, is added
Enter 1% acetum 100mL, stood after magnetic agitation 24 hours it is spare.
The pressure that the decompression low temperature is evaporated is 8-15kPa, and temperature is 4-12 DEG C.
Moist 3-8 parts of orchid is additionally added in step (2).
Soft cucurbit 3-8 parts are additionally added in step (3).
Beneficial effects of the present invention：The Chinese medicine composition for the treatment of depression prepared by the present invention has depression good
Good therapeutic effect is suitable for depression caused by many reasons, and applied widely, Chinese medicine composition of the invention can be made
Tablet, aqua, disintegrant, the pharmaceutically acceptable dosage form such as plaster, preparation method is simple, and raw material sources are wide, is suitble to scale
Industrial production.
Specific implementation mode
With reference to specific embodiment, the present invention will be further described.
Embodiment 1
A kind of Chinese medicine composition for treating depression, is made of the raw material of following parts by weight：Radix bupleuri 40g, Radix Polygalae 30g,
Radix Paeoniae Alba 25g, Fructus Aurantii 7g, Radix Glycyrrhizae 15g.
The preparation method of the Chinese medicine composition of above-mentioned treatment depression, carries out in accordance with the following steps：
(1) according to parts by weight, radix bupleuri 40g, Radix Polygalae 30g, Radix Paeoniae Alba 25g are taken, the water of 760mL is added to impregnate, is impregnated 2 hours,
It is placed in decoct and be decocted 2 hours in container, obtain decoction liquor；
(2) Fructus Aurantii 8g is taken, it is coarse powder to beat, and is placed in distillation container, adds the water of 40mL, infiltrates 1 hour；Quickly heat up to boiling
It rises, 30min, connection reflux condensing tube is kept to collect condensate liquid, obtain distillate；
(3) extracting liquorice 15g is crushed, and is crossed 50 mesh sieve, 30mL is added water-swellable 24 hours, and stirring is filtered with double gauze,
Filtrate adds the clarified solution of 60mL, and stirring stands 25min；Filtering, obtains filtered fluid；
The clarified solution is 1% chitosan solution, and preparation method is：Chitosan 1g is weighed, 1% acetum is added
100mL, stand after magnetic agitation 24 hours it is spare；
(4) by decoction liquor, distillate, filtered fluid merges, and decompression low temperature is evaporated the Chinese medicine composition that treatment depression is made；
The pressure that the decompression low temperature is evaporated is 10kPa, and temperature is 8 DEG C.
Embodiment 2
A kind of Chinese medicine composition for treating depression, is made of the raw material of following parts by weight：Radix bupleuri 30g, Radix Polygalae 20g,
Radix Paeoniae Alba 20g, Fructus Aurantii 3g, Radix Glycyrrhizae 10g.
The preparation method of the Chinese medicine composition of above-mentioned treatment depression, carries out in accordance with the following steps：
(1) according to parts by weight, radix bupleuri 30g, Radix Polygalae 20g, Radix Paeoniae Alba 20g are taken, the water of 420mL is added to impregnate, is impregnated 1 hour,
It is placed in decoct and be decocted 1 hour in container, obtain decoction liquor；
(2) Fructus Aurantii 3g is taken, it is coarse powder to beat, and is placed in distillation container, adds the water of 9mL, infiltrates 0.5 hour；It quickly heats up to
Boiling keeps 10min, connection reflux condensing tube to collect condensate liquid, obtain distillate；
(3) extracting liquorice 10g is crushed, and crosses 40 mesh sieve, water-swellable 16 hours of 10mL are added, stir, with double gauze mistake
Filter, filtrate add the clarified solution of 15mL, stir, and stand 20min；Filtering, obtains filtered fluid；The clarified solution is that 1% chitosan is molten
Liquid, preparation method are：Weigh chitosan 1g, 1% acetum 100mL be added, stood after magnetic agitation 24 hours it is spare；
(4) by decoction liquor, distillate, filtered fluid merges, and decompression low temperature is evaporated the Chinese medicine composition that treatment depression is made；
The pressure that the decompression low temperature is evaporated is 8kPa, and temperature is 4 DEG C.
Embodiment 3
A kind of Chinese medicine composition for treating depression, is made of the raw material of following parts by weight：Radix bupleuri 50g, Radix Polygalae 40g,
Radix Paeoniae Alba 30g, Fructus Aurantii 10g, Radix Glycyrrhizae 20g.
The preparation method of the Chinese medicine composition of above-mentioned treatment depression, carries out in accordance with the following steps：
(1) according to parts by weight, radix bupleuri 50g, Radix Polygalae 40g, Radix Paeoniae Alba 30g are taken, the water of 1200mL is added to impregnate, is impregnated 3 hours,
It is placed in decoct and be decocted 3 hours in container, obtain decoction liquor；
(2) Fructus Aurantii 10g is taken, it is coarse powder to beat, and is placed in distillation container, adds the water of 80mL, infiltrates 2 hours；It quickly heats up to
Boiling keeps 40min, connection reflux condensing tube to collect condensate liquid, obtain distillate；
(3) extracting liquorice 20g is crushed, and crosses 60 mesh sieve, water-swellable 32 hours of 60mL are added, stir, with double gauze mistake
Filter, filtrate add the clarified solution of 150mL, stir, and stand 30min；Filtering, obtains filtered fluid；The clarified solution is that 1% chitosan is molten
Liquid, preparation method are：Weigh chitosan 1g, 1% acetum 100mL be added, stood after magnetic agitation 24 hours it is spare；
(4) by decoction liquor, distillate, filtered fluid merges, and decompression low temperature is evaporated the Chinese medicine composition that treatment depression is made；
The pressure that the decompression low temperature is evaporated is 15kPa, and temperature is 12 DEG C.
Embodiment 4
A kind of Chinese medicine composition for treating depression, is made of the raw material of following parts by weight：Radix bupleuri 40g, Radix Polygalae 30g,
Radix Paeoniae Alba 25g, Fructus Aurantii 7g, Radix Glycyrrhizae 15g, moist orchid 5g.
The preparation method of the Chinese medicine composition of above-mentioned treatment depression, carries out in accordance with the following steps：
(1) according to parts by weight, radix bupleuri 40g, Radix Polygalae 30g, Radix Paeoniae Alba 25g are taken, the water of 760mL is added to impregnate, is impregnated 2 hours,
It is placed in decoct and be decocted 2 hours in container, obtain decoction liquor；
(2) Fructus Aurantii 8g is taken, moist orchid 5g, it is coarse powder to beat, and is placed in distillation container, adds the water of 65mL, infiltrates 1 hour；Soon
Speed is heated to boiling, and 30min, connection reflux condensing tube is kept to collect condensate liquid, obtain distillate；
(3) extracting liquorice 15g is crushed, and is crossed 50 mesh sieve, 30mL is added water-swellable 24 hours, and stirring is filtered with double gauze,
Filtrate adds the clarified solution of 60mL, and stirring stands 25min；Filtering, obtains filtered fluid；
The clarified solution is 1% chitosan solution, and preparation method is：Chitosan 1g is weighed, 1% acetum is added
100mL, stand after magnetic agitation 24 hours it is spare；
(4) by decoction liquor, distillate, filtered fluid merges, and decompression low temperature is evaporated the Chinese medicine composition that treatment depression is made；
The pressure that the decompression low temperature is evaporated is 10kPa, and temperature is 8 DEG C.
Embodiment 5
A kind of Chinese medicine composition for treating depression, is made of the raw material of following parts by weight：Radix bupleuri 40g, Radix Polygalae 30g,
Radix Paeoniae Alba 25g, Fructus Aurantii 7g, Radix Glycyrrhizae 15g, Cymbidium lancifolium (Cymbidium lancifolium Hook.) 5g.
The preparation method of the Chinese medicine composition of above-mentioned treatment depression, carries out in accordance with the following steps：
(1) according to parts by weight, radix bupleuri 40g, Radix Polygalae 30g, Radix Paeoniae Alba 25g are taken, the water of 760mL is added to impregnate, is impregnated 2 hours,
It is placed in decoct and be decocted 2 hours in container, obtain decoction liquor；
(2) Fructus Aurantii 8g, Cymbidium lancifolium 5g are taken, it is coarse powder to beat, and is placed in distillation container, adds the water of 65mL, infiltrates 1 hour；Soon
Speed is heated to boiling, and 30min, connection reflux condensing tube is kept to collect condensate liquid, obtain distillate；
(3) extracting liquorice 15g is crushed, and is crossed 50 mesh sieve, 30mL is added water-swellable 24 hours, and stirring is filtered with double gauze,
Filtrate adds the clarified solution of 60mL, and stirring stands 25min；Filtering, obtains filtered fluid；
The clarified solution is 1% chitosan solution, and preparation method is：Chitosan 1g is weighed, 1% acetum is added
100mL, stand after magnetic agitation 24 hours it is spare；
(4) by decoction liquor, distillate, filtered fluid merges, and decompression low temperature is evaporated the Chinese medicine composition that treatment depression is made；
The pressure that the decompression low temperature is evaporated is 10kPa, and temperature is 8 DEG C.
Embodiment 6
A kind of Chinese medicine composition for treating depression, is made of the raw material of following parts by weight：Radix bupleuri 40g, Radix Polygalae 30g,
Radix Paeoniae Alba 25g, Fructus Aurantii 7g, Radix Glycyrrhizae 15g, soft cucurbit 5g.
The preparation method of the Chinese medicine composition of above-mentioned treatment depression, carries out in accordance with the following steps：
(1) according to parts by weight, radix bupleuri 40g, Radix Polygalae 30g, Radix Paeoniae Alba 25g are taken, the water of 760mL is added to impregnate, is impregnated 2 hours,
It is placed in decoct and be decocted 2 hours in container, obtain decoction liquor；
(2) Fructus Aurantii 8g is taken, it is coarse powder to beat, and is placed in distillation container, adds the water of 40mL, infiltrates 1 hour；Quickly heat up to boiling
It rises, 30min, connection reflux condensing tube is kept to collect condensate liquid, obtain distillate；
(3) extracting liquorice 15g, soft cucurbit 5g are crushed, and are crossed 50 mesh sieve, 40mL are added water-swellable 24 hours, stirring, with bilayer
Filtered through gauze, filtrate add the clarified solution of 80mL, and stirring stands 25min；Filtering, obtains filtered fluid；
The clarified solution is 1% chitosan solution, and preparation method is：Chitosan 1g is weighed, 1% acetum is added
100mL, stand after magnetic agitation 24 hours it is spare；
(4) by decoction liquor, distillate, filtered fluid merges, and decompression low temperature is evaporated the Chinese medicine composition that treatment depression is made；
The pressure that the decompression low temperature is evaporated is 10kPa, and temperature is 8 DEG C.
Embodiment 7
A kind of Chinese medicine composition for treating depression, is made of the raw material of following parts by weight：Radix bupleuri 40g, Radix Polygalae 30g,
Radix Paeoniae Alba 25g, Fructus Aurantii 7g, Radix Glycyrrhizae 15g, persimmon leaf camphor tree osmanthus 5g.
The preparation method of the Chinese medicine composition of above-mentioned treatment depression, carries out in accordance with the following steps：
(1) according to parts by weight, radix bupleuri 40g, Radix Polygalae 30g, Radix Paeoniae Alba 25g are taken, the water of 760mL is added to impregnate, is impregnated 2 hours,
It is placed in decoct and be decocted 2 hours in container, obtain decoction liquor；
(2) Fructus Aurantii 8g is taken, it is coarse powder to beat, and is placed in distillation container, adds the water of 40mL, infiltrates 1 hour；Quickly heat up to boiling
It rises, 30min, connection reflux condensing tube is kept to collect condensate liquid, obtain distillate；
(3) extracting liquorice 15g, persimmon leaf camphor tree osmanthus 5g are crushed, and cross 50 mesh sieve, are added water-swellable 24 hours of 40mL, stirring, with double
Layer filtered through gauze, filtrate add the clarified solution of 80mL, stir, and stand 25min；Filtering, obtains filtered fluid；
The clarified solution is 1% chitosan solution, and preparation method is：Chitosan 1g is weighed, 1% acetum is added
100mL, stand after magnetic agitation 24 hours it is spare；
(4) by decoction liquor, distillate, filtered fluid merges, and decompression low temperature is evaporated the Chinese medicine composition that treatment depression is made；
The pressure that the decompression low temperature is evaporated is 10kPa, and temperature is 8 DEG C.
Comparative example 1
The extracting method of Fructus Aurantii extract carries out in accordance with the following steps：
(1) Fructus Aurantii 8g is taken, it is coarse powder to beat, and is placed in distillation container, adds the water of 40mL, infiltrates 1 hour；Quickly heat up to boiling
It rises, 30min, connection reflux condensing tube is kept to collect condensate liquid, obtain distillate；
(2) decompression low temperature, which is evaporated, is made Fructus Aurantii extract；The pressure that the decompression low temperature is evaporated is 10kPa, temperature 8
℃。
Experimental example 1：
Adaptability is raised 1 week before rat experiment, to adapt to environment.Neurological deficit score is carried out with Open field test, selects score
Similar rat 110 is randomly divided into 11 groups, every group 10, respectively embodiment 1-7 groups, 1 group of comparative example, depressed group (salt
Water group), Prozac group, normal group.
Normal group：It is divided to the gregarious raising of two cages to raise, press under mutually isolated environment with other group rats per 5, cage
According to bio-occlusion and feed and drinking-water is needed, any stimulation is not received.
Depressed group：In 56 days of experiment, this group of rat respectively feed by single cage, and receives a variety of different chronic stress thorns
Swash, arranges a kind daily, each average stimulation is used 8 times, and homologous stimulus discontinuously occurs, and prevents rat from expecting to occur
Stimulation, physiological saline 1ml gavages are given after 28 days daily.
Various stimulating methods are specific as follows：
(1) ice water is swum：Animal is put into the bucket for filling 4 DEG C of water (15 centimetres of the depth of water), the rigid energy of rear toe of rat
A barrel bottom is touched, animal is taken out put back in cage after five minutes.
(2) tail is hanged：Hand-held rat tail, makes rat head downward, rotates rat.
(3) prohibit water：It cuts off the water supply within 24 hours.
(4) it shocks by electricity：It is ingenious to use electric acupuncture apparatus, extend positive and negative anodes probe length with iron wire, two probes are placed in rat body not
Same position, turns on the switch, voltage 36V, current strength 1m A, every time lasting 15s, turns off the switch 0.5 minute, is repeated 20 times, will
Rat puts back to rearging cage.
(5) tail is pressed from both sides：Rat is put into fixed cage, exposes tail, is clamped away from root of the tail 1cm with haemostatic clamp, firmly should not
It is excessive, so that rat is sent out sound of wailing, continues 1 minute, rat is put back into rearging cage.
(6) it illuminates all night：Fluorescent lamp is opened at dark, rat is made to be in illumination conditions at night.
(7) fasting：Feed is not provided in 24 hours.
Prozac group：Feeding environment and stimulation mode are given according to 2.5mg/Kg dosage gavages with depressed group after 28 days daily
Medicine.
1 group of embodiment 1-7 groups, comparative example：Feeding environment and stimulation mode are with depressed group, daily according to 10mg/ after 28 days
Kg dosage gastric infusions, still lasting stimulation during administration.
Test (open-field) scoring in wilderness：
Spacious each 80 centimetres of case length, the inner wall of case and bottom surface are painted black, and bottom surface is divided into 25 of area equation
Rat is placed among spacious case by grid, to pass through score of the number of squares as horizontal movement of bottom surface, passes through a lattice and obtains 1 point, with double
The liftoff upright number of foot is vertical score, biped is liftoff primary 1 point, minute 3min.In experiment the 3rd day, 28
It, each measurement in 56 days 1 time, final relatively each group score difference.The index can reflect activities in rats degree and to fresh ambient
Curious degree, wherein horizontal movement reflect rat motor level of activity, vertical movement how much reflect it to extraneous fresh ambient
Curiosity find out desire degree.
Test result is as shown in Table 1 and Table 2：
1 each group rat open-field horizontal movements of table scoring is compared (secondary/3min)
Note：* P is represented<0.05；* represents P<0.01.
2 each group rat open-field horizontal movements of table scoring is compared (secondary/3min)
Note：* P is represented<0.05；* represents P<0.01.
As can be seen from Table 1, the scoring no significant difference of each group open-field horizontal movements in the 3rd day, 28d depressions are tested
Obviously scoring declines for disease group, Prozac group, embodiment 1-3 and comparative example 1, the 56th day, and the scoring of depression group continues to decline, and fluorine
Xi Ting groups rise close to normal group level, and embodiment 1-3 significantly rises, it was demonstrated that drug of the invention plays antidepressant work(
Effect, and comparative example 1 is not obviously improved, and is declined instead, it was demonstrated that no antidepressant effect is used alone in Fructus Aurantii extract,
It plays the role of reconciliation in the composition, as making medicine.
As can be seen from Table 2, the 28th day and the 56th day, embodiment 5 scored be not significantly different compared with Example 1, card
Bright addition Cymbidium lancifolium does not have an antidepressant effect, embodiment 4, embodiment 6, and embodiment 7 is scored compared with Example 1 on significantly
It rises, it was demonstrated that moist orchid is added, soft cucurbit, persimmon leaf camphor tree osmanthus has antidepressant effect.
Non-swimming time measures：
Bucket length and width is 25 centimetres each, 40 centimetres high, and rat is put into bucket, and rat struggles first to make an attempt at escaping, then
In a kind of motionless state, motionless state refers to that rat stops struggling in water, in a kind of motionless state of floating, once in a while with
For limb activity to ensure that head is kept afloat, this state is referred to as " behavioral despair ", and the swimming in accumulative each rat 5min is not
The dynamic time.In the 3rd day of experiment, 28 days, each measurement in 56 days it is primary, which can reflect the degree of rat feeling of despair.
Test result is as shown in Table 3 and Table 4：
The 3 each group rats'swimming dead time of table compares (s/5min)
Note：* P is represented<0.05；* represents P<0.01.
The 4 each group rats'swimming dead time of table compares (s/5min)
Note：* P is represented<0.05；* represents P<0.01.
As can be seen from Table 3, experiment the 3rd day each group rats'swimming dead time no significant difference, 28d depression groups,
Prozac group, embodiment 1-3 and 1 rats'swimming dead time of comparative example significantly increase (P<0.01), the 56th day, depression group
The rats'swimming dead time rises, and Prozac group decline is close horizontal to normal group, and embodiment 1-3 is remarkably decreased, it was demonstrated that this hair
Bright drug plays antidepressant effect, and comparative example 1 is not decreased obviously, it was demonstrated that Fructus Aurantii extract is used alone without anti-
Effect of depression, plays the role of reconciliation in the composition, as making medicine.
As can be seen from Table 4, the 28th day and the 56th day, the rats'swimming dead time did not had embodiment 5 compared with Example 1
Significant difference, it was demonstrated that Cymbidium lancifolium, which is added, does not have antidepressant effect, and embodiment 4, embodiment 6, embodiment 7 is compared with Example 1
The rats'swimming dead time is remarkably decreased, it was demonstrated that moist orchid is added, soft cucurbit, persimmon leaf camphor tree osmanthus has antidepressant effect.
Experimental example 2：
Chapter, female, 39 years old.Depressed, anxiety, insomnia loses interest in anything, thoughts of suicide is strong.It is oral real
The Chinese medicine composition obtained for treating depression in example 1 is applied, once a day, takes orally 5g, continuous treatment 6 months every time.Symptom is basic
It disappears, mental state and mood are normal, resourceful, and diet, sleep are normal, and somatization disappears, and can adapt to daily life work completely
Make.
Poplar, man, 56 years old.Depressed, easily sad, when sad sorrow, is intended to cry, and life enthusiasm interest declines, capricious,
Fatigue and weak has thoughts of suicide.The Chinese medicine composition obtained for treating depression in oral embodiment 7, once a day, each mouth
5g is taken, continuous treatment 6 months.Symptom disappears substantially, and mental state and mood are normal, resourceful, and diet, sleep are normal, body disease
Shape disappears, and can adapt to daily life and work completely.
Claims (9)
1. a kind of Chinese medicine composition for treating depression, which is characterized in that be made of the raw material of following parts by weight：Radix bupleuri 30-
50 parts, 20-40 parts of Radix Polygalae, 20-30 parts of Radix Paeoniae Alba, 3-10 parts of Fructus Aurantii, 10-20 parts of Radix Glycyrrhizae.
2. treating the Chinese medicine composition of depression according to claim 1, which is characterized in that the Chinese medicine composition also wraps
Include moist 3-8 parts of orchid.
3. treating the Chinese medicine composition of depression according to claim 1, which is characterized in that the Chinese medicine composition also wraps
Include soft cucurbit 3-8 parts.
4. described in claim 1 treat depression Chinese medicine composition preparation method, which is characterized in that in accordance with the following steps into
Row：
(1) according to parts by weight, 30-50 parts of radix bupleuri is taken, 20-40 parts of Radix Polygalae, 20-30 parts of Radix Paeoniae Alba adds 6-12 times of parts by weight
Water impregnates, and impregnates 1-3 hours, is placed in decoction container and decocts 1-3 hours, obtains decoction liquor；
(2) 3-10 parts of Fructus Aurantii is taken, it is coarse powder to beat, and is placed in distillation container, adds the water of 3-8 times of parts by weight, infiltration 0.5-2 small
When；Boiling is quickly heated up to, 10-40min, connection reflux condensing tube is kept to collect condensate liquid, obtain distillate；
(3) it extracting liquorice 10-20 parts, crushes, crosses 40-60 mesh sieve, water-swellable 16-32 hours of 1-3 times of parts by weight are added, stir
It mixes, with filtered through gauze, filtrate adds the clarified solution of 3-5 times of parts by weight, and stirring stands 20-30min；Filtering, obtains filtered fluid；
(4) by decoction liquor, distillate, filtered fluid merges, and decompression low temperature is evaporated the Chinese medicine composition that treatment depression is made.
5. the preparation method of the Chinese medicine composition for the treatment of depression according to claim 1, which is characterized in that the gauze is
Double gauze.
6. the preparation method of the Chinese medicine composition for the treatment of depression according to claim 1, which is characterized in that the clarified solution
For 1% chitosan solution；The preparation method of the chitosan solution is：Chitosan 1g is weighed, 1% acetum is added
100mL, stand after magnetic agitation 24 hours it is spare.
7. the preparation method of the Chinese medicine composition for the treatment of depression according to claim 1, which is characterized in that the decompression is low
The pressure that temperature is evaporated is 8-15kPa, and temperature is 4-12 DEG C.
8. the preparation method of the Chinese medicine composition for the treatment of depression according to claim 1, which is characterized in that in step (2)
It is additionally added moist 3-8 parts of orchid.
9. the preparation method of the Chinese medicine composition for the treatment of depression according to claim 1, which is characterized in that in step (3)
It is additionally added soft cucurbit 3-8 parts.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1416880A (en) * | 2002-11-27 | 2003-05-14 | 北京中医药大学 | New use of powder for regulating liver and spleen and its active part |
| CN102949656A (en) * | 2012-11-14 | 2013-03-06 | 西安福安创意咨询有限责任公司 | Health care product capsule used for preventing and treating depression and preparation method thereof |
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2018
- 2018-05-10 CN CN201810441561.3A patent/CN108354993A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1416880A (en) * | 2002-11-27 | 2003-05-14 | 北京中医药大学 | New use of powder for regulating liver and spleen and its active part |
| CN102949656A (en) * | 2012-11-14 | 2013-03-06 | 西安福安创意咨询有限责任公司 | Health care product capsule used for preventing and treating depression and preparation method thereof |
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