CN108354906A - A kind of medicinal oral instant dissipates and preparation method thereof - Google Patents
A kind of medicinal oral instant dissipates and preparation method thereof Download PDFInfo
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- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
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- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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Abstract
Dissipated the invention discloses a kind of medicinal oral instant and preparation method thereof, which dissipates is made of drug and auxiliary material, and grain size is less than 50 μm, and the auxiliary material includes water soluble adjuvant.The present invention instantaneously generates a large amount of salivas using water soluble adjuvant stimulation oral cavity, water soluble adjuvant is dissolved in saliva, it is in hyperosmosis state to make saliva, a large amount of salivas can promote drug powder quickly to swallow, and, inhibit the dissolving release of drug in the oral cavity, so that the present invention can take under anhydrous conditions, avoid children and old man that reflectivity is caused to choke cough when drinking water and taking medicine, and, the oral instant dissipates when taking without sand feeling, the oral cavity residence time is short, it is few to take rear oral cavity residual, and astringent taste can be sheltered by coating odor mask and corrigent, bad smell, reduce bitter taste, and with pleasant sweet tea, tart flavour and refrigerant sense, so that children are easy to receive with old man, it is difficult to reduce medication, to ensure take medicine continuity and therapeutic effect.
Description
Technical field
The invention belongs to medicine, field of health care products, and in particular to a kind of medicinal oral instant dissipates and preparation method thereof.
Background technology
Children and the group of people at high risk that old man is the insufficient special population of function of deglutition and disease.According to 2010 the 6th
Secondary census data shows that the children's population of China 0-14 Sui is about 2.2 hundred million, it is contemplated that by 2024, children were expected to reach 2.65
Hundred million.Children's medical treatment Number of Outpatients is found by inquiry, and the two weeks morbidity rate of 0-4 Sui children is up to 174.2%, 5-14 Sui children two
All illness rates are also up to 76.9%.For the elderly, China in 2015 60 years old and the above population reach 2.22 hundred million, account for total population
16.15%.The year two thousand twenty is expected, elderly population reach 2.48 hundred million, and aging level reaches 17.17%, wherein 80 years old or more old
Year population is up to 30,670,000 people；2025, the above population of threescore was up to 300,000,000, became super senior type country.
Children and old man have in common that function of deglutition deficiency, and adult or young man is needed to guard medication.It is existing
Form of administration has some limitations to some extent again, such as using tablet, pill, capsule as the solid pharmaceutical preparation of representative, though
The residence time is short in the oral cavity, and drug dissolves less, bitter taste stimulation is weaker, but is not suitable for the children or old man of dysphagia,
In addition it clinically often needs the former dosage form of destruction to be administered with divided dose, and the large area of drug powder can be caused to expose.Although powder
Convenient for swallowing, but since its bitter taste is prominent, sand feeling is strong, the residence time is long, takes rear oral cavity and remain more, various unhappiness tastes
Road interweaves, and generally requires great quantity of water drinking, it is also possible to cause reflexive cough of choking, thus not liked by patient.Therefore, how needle
It to the physilogical characteristics of old man and children, designs that mouthfeel is excellent, is easy to the dosage form swallowed, independently takes medicine with children for old man,
Ensure that medication continuity and therapeutic effect are of great significance.
Invention content
It is an object of the invention to：For above-mentioned existing powder because needing great quantity of water drinking that reflectivity is easily caused to be choked cough, and nothing
Method is suitable for the problem of insufficient children of function of deglutition and old man, and a kind of medicinal oral instant of present invention offer dissipates and its preparation side
Method.
The technical solution adopted by the present invention is as follows：
A kind of medicinal oral instant is scattered, is made of drug and auxiliary material, and grain size is less than 50 μm, and the auxiliary material includes water solubility
Auxiliary material.
It is the powder for being less than 50 μm by the grain size that drug and water soluble adjuvant are prepared by mixing into, clothes that oral instant of the present invention, which dissipates,
Used time, water soluble adjuvant meets saliva dissolving, while oral cavity being stimulated instantaneously to generate a large amount of salivas, and water soluble adjuvant dissolving is promoted to fill
Point, it is in hyperosmosis state to make saliva, and a large amount of salivas can promote drug powder quickly to swallow, also, inhibits drug in the oral cavity
Dissolving release so that the present invention can take under anhydrous conditions, and children and old man is avoided to cause reflectivity when drinking water and taking medicine
It chokes cough, also, the oral instant dissipates when taking without sand feeling, the oral cavity residence time is short, and it is few to take rear oral cavity residual.
Further, drug is chemicals or Chinese medicine.
Further, the chemicals are chemical drugs monomer or combinations thereof object.
Further, the Chinese medicine is the primary medicinal powder of Chinese medicine, traditional Chinese medicinal extract powder or Chinese medicine grease and extract.
Further, the mass ratio of chemicals and auxiliary material is (1-40)：20.
Further, the mass ratio of Chinese medicine and auxiliary material is (1-30)：10.
Further, water soluble adjuvant includes one in cane sugar powder, powdered glucose, lactose powder, mannitol, soluble starch
Kind is a variety of.These water soluble adjuvant good hydrophilic properties can stimulate oral cavity instantaneously to generate a large amount of salivas, and have certain sweet tea
Taste can carry out flavoring so that children are easy to receive with old man to drug.
Further, auxiliary material further includes corrigent.
Further, corrigent includes xylitol, acesulfame potassium, Aspartame, steviol glycoside, neotame, Sucralose, sugar
It is one or more in essence, maltitol, menthol, peppermint oil, citric acid.
Although oral liquid also has the function of swallowing, drug mostly exists with molecular state or colloidal form,
Dispersion degree is big, and especially bitter principle can simultaneously form extensively and strong impulse, since bitter taste perceives receptor and sweet receptor
And differ so that conventional sweet substance flavoring is difficult to shelter preparation bitter taste, and the present invention rectifys on the basis of powder
Taste, bitter taste of drug masking effect are good.
Further, auxiliary material further includes cladding odor mask.
Further, cladding odor mask includes in silica, porous-starch, beta-cyclodextrin, hydroxypropyl-β-cyclodextrin
It is one or more.
For children with old man to the offending smell poor resistance of drug, oral instant of the present invention is dissipated coats taste masking by addition
Agent, masking agents astringent taste, bad smell reduce bitter taste, and with pleasant sweet tea, tart flavour and refrigerant sense so that children and old man
It is easy to receive, it is difficult reduces medication.
A kind of preparation method that medicinal oral instant is scattered, includes the following steps：
(1) drug grinding is prepared into the powder that grain size is 5-20 μm；
(2) water soluble adjuvant grinding is prepared into the powder that grain size is 0.2-3 μm；
(3) the powder mixing in step (1) and step (2) is dissipated to get the medicinal oral instant.
Further, when auxiliary material includes cladding odor mask, in step (1), by drug and cladding odor mask mixed grinding system
The standby powder for being 5-20 μm at grain size.
Further, when auxiliary material includes corrigent, in step (2), it is 0.3-5 that water soluble adjuvant grinding, which is prepared into grain size,
μm powder after grinding is prepared into grain size is 0.2-3 μm of powder together with corrigent.
In conclusion by adopting the above-described technical solution, the beneficial effects of the invention are as follows：
1. the present invention instantaneously generates a large amount of salivas using water soluble adjuvant stimulation oral cavity, water soluble adjuvant is dissolved in saliva, makes
Saliva is in hyperosmosis state, and a large amount of salivas can promote drug powder quickly to swallow, also, inhibits the dissolving of drug in the oral cavity
Release so that the present invention can take under anhydrous conditions, avoid children and old man that reflectivity is caused to choke cough when drinking water and taking medicine, and
And the oral instant dissipates when taking without sand feeling, the oral cavity residence time is short, and it is few to take rear oral cavity residual；
2. relative to oral liquid since drug molecule dispersion degree is big, conventional sweet substance flavoring is difficult to the system of sheltering
Agent bitter taste, the present invention carry out flavoring on the basis of powder, and bitter taste of drug masking effect is good, and can also be by coating odor mask
Astringent taste, bad smell are sheltered, reduces bitter taste, and with pleasant sweet tea, tart flavour and refrigerant sense so that children are easy to connect with old man
By reduction medication is difficult, to ensure take medicine continuity and therapeutic effect.
Description of the drawings
Fig. 1 is that bulbus fritillariae cirrhosae coarse powder dissipates electronic tongues signal PCA figures with bulbus fritillariae cirrhosae oral instant；
Fig. 2 is VAS bitter taste standards of grading figures.
Specific implementation mode
All features disclosed in this specification can be with any other than mutually exclusive feature and/or step
Mode combines.
Embodiment 1
American cockroach oral instant dissipates, in parts by weight, including 10 parts of American cockroach, 2-4 parts of cane sugar powder, powdered glucose
0.2-0.5 parts, 0.5-1 parts of silica, 0.2-0.5 parts of porous-starch, 1-2 parts of xylitol, 1-2 parts of maltitol, menthol
0.05-0.1 parts.
The scattered preparation method of American cockroach oral instant：American cockroach mixes with silica, porous-starch, using vibration
Barreling is milled to 5-20 μm, and cane sugar powder and powdered glucose grinding are prepared into after the powder that grain size is 0.3-5 μm and xylitol, maltose
Alcohol, menthol mixed grinding are to 0.2-3 μm, above-mentioned two parts powder mixing in vibromill, and vibromill charge ratio of media is not low
In 80%, obtains American cockroach oral instant and dissipate.
Embodiment 2
Radix Notoginseng oral instant dissipates, in parts by weight, including 6 parts of Radix Notoginseng, 1-2 parts of cane sugar powder, 1-2 parts of powdered glucose, dioxy
0.05-0.1 parts of SiClx, 0.1-0.2 parts of maltitol, 0.05-0.1 parts of citric acid.
The scattered preparation method of Radix Notoginseng oral instant：Radix Notoginseng mixes with silica, is ground to 5-20 μm using vibromill, sugarcane
Icing Sugar and powdered glucose grinding be prepared into grain size be after 0.3-5 μm of powder with maltitol, citric acid mixed grinding to 0.2-3
μm, above-mentioned two parts powder mixing in vibromill obtains Radix Notoginseng oral instant and dissipates.
Embodiment 3
Bulbus fritillariae cirrhosae oral instant dissipate, in parts by weight, including 6 parts of bulbus fritillariae cirrhosae, 1-2 parts of cane sugar powder, 1-2 parts of powdered glucose,
0.05-0.1 parts of silica, 0.05-0.2 parts of Aspartame, 0.1-0.2 parts of citric acid.
The scattered preparation method of bulbus fritillariae cirrhosae oral instant：Bulbus fritillariae cirrhosae is mixed with silica, and 5-20 μ are ground to using vibromill
M, cane sugar powder and powdered glucose grinding are prepared into after the powder that grain size is 0.3-5 μm with Aspartame, citric acid mixed grinding extremely
0.2-3 μm, above-mentioned two parts powder mixing in vibromill obtains bulbus fritillariae cirrhosae oral instant and dissipates.
Embodiment 4
Ganoderma spove powder oral instant dissipates, in parts by weight, including 6 parts of ganoderma spove powder, cane sugar powder 1-2
Part, 0.1-0.5 parts of silica, 0.05-0.1 parts of citric acid, 0.01-0.1 parts of menthol, 2-5 parts of xylitol.
The scattered preparation method of ganoderma spove powder oral instant：Ganoderma spove powder is mixed with silica, is used
Vibromill is ground to 5-20 μm, and cane sugar powder grinding is prepared into after the powder that grain size is 0.3-5 μm and citric acid, menthol, xylose
For alcohol mixed grinding to 0.2-3 μm, above-mentioned two parts powder mixing in vibromill obtains ganoderma spove powder oral instant
It dissipates.
Embodiment 5
Rhizoma Gastrodiae oral instant dissipates, in parts by weight, including 7 parts of Rhizoma Gastrodiae, 2 parts of cane sugar powder, 1 part of powdered glucose.
The scattered preparation method of Rhizoma Gastrodiae oral instant：Rhizoma Gastrodiae is ground to 5-20 μm using vibromill, cane sugar powder, powdered glucose
Mixed grinding is to 0.2-3 μm, above-mentioned two parts powder mixing in vibromill, obtains Rhizoma Gastrodiae oral instant and dissipates.
Embodiment 6
Red sage root oral is instant to be dissipated, in parts by weight, including 6 parts of Radix Salviae Miltiorrhizae, 2 parts of cane sugar powder, 1 part of powdered glucose, Aspartame
0.05-0.1 parts, 0.05-0.1 parts of menthol.
The instant scattered preparation method of red sage root oral：Radix Salviae Miltiorrhizae is ground to 5-20 μm using vibromill, cane sugar powder and glucose
Powder grinding is prepared into after the powder that grain size is 0.3-5 μm with Aspartame, menthol mixed grinding to 0.2-3 μm, above-mentioned two
Divide powder mixing in vibromill, it is instant scattered to obtain red sage root oral.
Embodiment 7
Ginseng oral is instant to be dissipated, in parts by weight, including 6 parts of ginseng, 3-4 parts of powdered glucose, 0.05-0.1 parts of neotame, lemon
0.05-0.1 parts of lemon acid, 0.05-0.1 parts of menthol.
The instant scattered preparation method of ginseng oral：Ginseng is ground to 5-20 μm using vibromill, powdered glucose grinding system
With neotame, citric acid, menthol mixed grinding to 0.2-3 μm after the standby powder for being 0.3-5 μm at grain size, above-mentioned two parts powder
It is instant scattered to obtain ginseng oral for the mixing in vibromill.
Embodiment 8
Feel the double clear oral instants of cough to dissipate, in parts by weight, including 1 part of andrographolide, 4 parts of scutelloside, cane sugar powder 5-10
Part, 0.1-0.5 parts of silica, 1-2 parts of xylitol, 0.2-0.5 parts of Aspartame, 0.1-0.3 parts of menthol, citric acid 0.1-
0.3 part.
Feel the scattered preparation method of the double clear oral instants of cough：Scutelloside, andrographolide are mixed with silica, using vibration
Barreling is milled to 5-20 μm, cane sugar powder grinding be prepared into after the powder that grain size is 0.3-5 μm with xylitol, Aspartame, menthol,
Citric acid mixed grinding is to 0.2-3 μm, above-mentioned two parts powder mixing in vibromill, obtains the double clear oral instants of sense cough and dissipates.
Embodiment 9
Children's compound the membrane of a chicken's gizzard oral instant dissipates, in parts by weight, including 3.4 parts of the membrane of a chicken's gizzard, 6.6 parts of Medicated Leaven, sucrose
1-3 parts of powder, 2-4 parts of powdered glucose, 1-2 parts of porous-starch, 0.1-0.3 parts of menthol, 0.1-0.3 parts of citric acid.
The scattered preparation method of children's compound the membrane of a chicken's gizzard oral instant：The membrane of a chicken's gizzard, Medicated Leaven are mixed with porous-starch, using shaking
Dynamic barreling is milled to 5-20 μm, and cane sugar powder and powdered glucose grinding are prepared into after the powder that grain size is 0.3-5 μm and menthol, lemon
For sour mixed grinding to 0.2-3 μm, above-mentioned two parts powder mixing in vibromill obtains children's compound the membrane of a chicken's gizzard oral instant
It dissipates.
Embodiment 10
Anti- sense oral instant dissipates, and includes the anti-sense extract powder 3 prepared by honeysuckle, radix paeoniae rubra, thick wood-fern rhizome in parts by weight
Part, 2 parts of cane sugar powder, 0.2-0.5 parts of maltitol, 0.01-0.05 parts of menthol, 0.01-0.05 parts of citric acid.
The scattered preparation method of anti-sense oral instant：Anti- sense extract powder is ground to 5-20 μm using vibromill, cane sugar powder is ground
With maltitol, menthol, citric acid mixed grinding to 0.2-3 μm after the powder that prepared by mill is 0.3-5 μm at grain size, above-mentioned two
Amount of powder mixing in vibromill obtains anti-sense oral instant and dissipates.
Experimental example 1
Bulbus fritillariae cirrhosae oral instant, which dissipates, to be prepared：Bulbus fritillariae cirrhosae coarse powder 240g and 4g silica are taken, is put into vibromill, medium is filled out
Rate 80% is filled, column stainless steel medium, amplitude 4mm, milling time 18min, 20 DEG C of operating temperature, taking-up, as sample 1 are surveyed
Determine grain size.Cane sugar powder (0.3-5 μm) 80g, powdered glucose (0.3-5 μm) 40g, Aspartame 2g, citric acid 4g is taken to be placed in vibration
In mill, mixed grinding 4min takes out, as sample 2, measures grain size.Sample 1 is mixed into 8min with sample 2 in vibromill, is taken
Go out and dissipated to get bulbus fritillariae cirrhosae oral instant, measures grain size.
(1) particle size determination：Malvern particle size determination instrument dry method measures, sample minute 12s, BACKGROUND Time 8s, commonly
Pattern, sample signal strength 0.5-6；Disperse sample introduction control：Air pressure 200kPa, sample introduction speed 50%；It is built according to above-mentioned condition
Vertical bioassay standard operation process of measurement SOP.Measurement result is shown in Table 1, and the particle size range d 0.9 of sample 1 is at 18 μm or so, sample 2
Particle size range d 0.9 at 2.833 μm or so, the particle size range d 0.9 of sample 3 is at 38 μm or so；And traditional tendril-leaved fritillary bulb female powder
D 0.9 at 90 μm or so.
1 particle size determination result of table
(2) i.e. dissolubility measures：It takes 0.1g bulbus fritillariae cirrhosae oral instants to dissipate with 0.1g bulbus fritillariae cirrhosaes coarse powder respectively to turn in basket loaded on small,
Turn basket by small and slowly immerse in artificial saliva, lift after 10 seconds, observation turns in basket that whether there is or not powder residuals, if noresidue, it was demonstrated that i.e.
Dissolubility is good.The result shows that 0.1g bulbus fritillariae cirrhosae oral instants are dispersed in 4-6s and dissolve completely, the i.e. dissolubility of sample is good, and tendril-leaved fritillary bulb
Female coarse powder only has few powder in 10s and dissolves, and amount of powder wetting largely remains in and turns in basket.
(3) electronic tongues measure：25 DEG C, data acquisition time 120s, collection period 1s of collecting temperature, agitation speed 1rs-1.Using ultra-pure water as cleaning solution, cleaning sensor 10s before sample is measured every time.Take 0.5g bulbus fritillariae cirrhosaes coarse powder and 0.5g bulbus fritillariae cirrhosae mouths
Chamber is instant to be dissipated, and is respectively placed in 50ml standard configuration beakers, is measured.Parallel determination 10 times as stated above of every part of sample, for
To reliable and stable data, take last 3 data as output valve, 3 output valves of every part of sample are averaged as at the later stage
Manage data.Measurement result is shown in that Fig. 1, bulbus fritillariae cirrhosae coarse powder are dispersed in electronic tongues signal system with bulbus fritillariae cirrhosae oral instant in the presence of apparent poor
It is different, thus illustrate, be prepared into oral instant dissipate after, significant change has occurred in the taste of bulbus fritillariae cirrhosae.
(4) mouthfeel measures：With adult for volunteer's receptor, common visual analogue scales (VAS) is selected to evaluate.VAS
It is a kind of method medically indicating pain, and the quantization to mood, bitter taste and warmth sensation, taste satisfaction etc., has
Simply and intuitively advantage, and the state of mind will not be caused to bear volunteer.According to VAS bitter taste standards of grading figures, volunteer according to
The power of tasted sample scores.
Such as Fig. 2, one end of the horizontal line of standardized 10cm on paper, horizontal line is 0, indicates painless, the other end 10, indicates
Severe pain, middle section indicate different degrees of pain.It allows patient according to the standardized mark on horizontal line is felt, indicates pain
Degree.And bitterness staging is similar with pain, the power of bitter taste does not have corresponding physiologic index that can apply, therefore joins
It examines " clinically used Pain Grading method (VAS) ", one end of horizontal line is 0, indicates that no hardship, the other end 10 indicate extremely strong
Strong bitter taste cannot receive, and middle section indicates different degrees of bitter taste, as slight bitter, mild hardship, moderate strength it is bitter, strong
Hardship but can receive reluctantly.
Volunteer mouthful tastes experiment and shows that bulbus fritillariae cirrhosae coarse powder has apparent sand feeling, bitter to be not easy to swallow, and bulbus fritillariae cirrhosae mouth
Chamber it is instant dissipate take after without any sand feeling, sweet slightly sour, just melt in the mouth, without apparent bitter taste.10 volunteer's VAS grade forms
Bright, the VAS scorings of bulbus fritillariae cirrhosae coarse powder are 6.01 ± 1.40, belong to moderate hardship, and the VAS that bulbus fritillariae cirrhosae oral instant dissipates is commented
It is divided into 1.63 ± 0.52, belongs to slight bitter, mouthfeel is obviously improved.
(5) color evenness measures：It takes bulbus fritillariae cirrhosae oral instant to dissipate, is laid on blank sheet of paper, strikes off, color and luster is shallow lime
Color is visible by naked eyes second of color.
Experimental example 2
Children's compound the membrane of a chicken's gizzard oral instant, which dissipates, to be prepared：The membrane of a chicken's gizzard coarse powder 68g, Medicated Leaven 132g and porous-starch 40g are taken,
It puts into vibromill, charge ratio of media 80%, column stainless steel medium, amplitude 4mm, milling time 5.6min, operating temperature 20
DEG C, it takes out, as sample 1.Take cane sugar powder (0.3-5 μm) 60g, powdered glucose (0.3-5 μm) 40g, menthol 4g, citric acid 6g
It is placed in vibromill, mixed grinding 2min, takes out, as sample 2.Sample 1 is mixed into 3min with sample 2 in vibromill, is taken
Go out and dissipated to get children's compound the membrane of a chicken's gizzard oral instant, children's compound the membrane of a chicken's gizzard oral instant is dissipated and is compared with commercial product,
The results are shown in Table 2, the results showed that, the scattered grain size of oral instant is dissipated significantly less than commercially available children's compound the membrane of a chicken's gizzard, i.e. dissolubility in 4-7s,
Commercially available children's compound the membrane of a chicken's gizzard is also significantly better than to dissipate.Commercially available children's compound the membrane of a chicken's gizzard dissipates, and there are the fishy smell of the strong the membrane of a chicken's gizzard, systems
After being dissipated at oral instant, fishy smell is preferably covered, and mouthfeel is also optimised.
2 children's compound the membrane of a chicken's gizzard oral instant of table dissipates and commercially available product performance comparison
Experimental example 3
Ganoderma spove powder oral instant, which dissipates, to be prepared：Ganoderma spove powder 240g and silica 8g, input is taken to shake
In dynamic mill, charge ratio of media 80%, column stainless steel medium, amplitude 4mm, milling time 4min, 20 DEG C of operating temperature, taking-up,
As sample 1.It takes cane sugar powder (0.3-5 μm) 80g, xylitol 160g, citric acid 2g, menthol 2g to be placed in vibromill, mixes
3min is ground, is taken out, as sample 2.Sample 1 is mixed into 2min with sample 2 in vibromill, is taken out, as wall-breaking lucidum spore
Sub- powder oral instant dissipates, and ganoderma spove powder oral instant is dissipated and is compared with ganoderma spove powder, the results are shown in Table 3,
The result shows that the grain size of ganoderma spove powder is dissipated significantly less than ganoderma spove powder oral instant, but wall-broken ganoderma spore
The i.e. dissolubility ＞ 10s of powder, and ganoderma spove powder oral instant dissipates i.e. dissolubility in 3-5s ranges, the i.e. dissolubility that oral instant dissipates
It is significantly superior.Ganoderma spove powder is directly placed into mouth with slight bitter taste and grease taste, and wall-broken ganoderma spore
Powder oral instant spills into that mouth is instant, and bitter taste is covered completely with grease taste, and sweet acid, with refrigerant sense, mouthfeel is also able to excellent
Change.
3 ganoderma spove powder oral instant of table dissipates and ganoderma spove powder performance comparison
It is the embodiment of the present invention as described above.The present invention is not limited to the above-described embodiments, anyone should learn that
The structure change made under the inspiration of the present invention, the technical schemes that are same or similar to the present invention each fall within this
Within the protection domain of invention.
Claims (10)
1. a kind of medicinal oral instant dissipates, which is characterized in that be made of drug and auxiliary material, grain size is less than 50 μm, the auxiliary material
Including water soluble adjuvant.
2. a kind of medicinal oral instant according to claim 1 dissipate, which is characterized in that the drug be chemicals or in
Medicine.
3. a kind of medicinal oral instant according to claim 2 dissipates, which is characterized in that the matter of the chemicals and auxiliary material
Amount is than being (1-40)：20.
4. a kind of medicinal oral instant according to claim 2 dissipates, which is characterized in that the mass ratio of the Chinese medicine and auxiliary material
For (1-30)：10.
5. a kind of medicinal oral instant according to claim 1 dissipates, which is characterized in that the water soluble adjuvant includes sucrose
It is one or more in powder, powdered glucose, lactose powder, mannitol, soluble starch.
6. a kind of medicinal oral instant according to claim 1 dissipates, which is characterized in that the auxiliary material further includes corrigent.
7. a kind of medicinal oral instant according to claim 6 dissipate, which is characterized in that the corrigent include xylitol,
In acesulfame potassium, Aspartame, steviol glycoside, neotame, Sucralose, saccharin, maltitol, menthol, peppermint oil, citric acid
It is one or more.
8. a kind of medicinal oral instant according to claim 1 dissipates, which is characterized in that the auxiliary material further includes cladding taste masking
Agent.
9. a kind of medicinal oral instant according to claim 8 dissipates, which is characterized in that the cladding odor mask includes dioxy
It is one or more in SiClx, porous-starch, beta-cyclodextrin, hydroxypropyl-β-cyclodextrin.
10. a kind of scattered preparation method of medicinal oral instant, which is characterized in that include the following steps：
(1) drug grinding is prepared into the powder that grain size is 5-20 μm；
(2) water soluble adjuvant grinding is prepared into the powder that grain size is 0.2-3 μm；
(3) the powder mixing in step (1) and step (2) is dissipated to get the medicinal oral instant.
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