CN108261376B - Three-dimensional moisturizing factor - Google Patents
Three-dimensional moisturizing factor Download PDFInfo
- Publication number
- CN108261376B CN108261376B CN201810181620.8A CN201810181620A CN108261376B CN 108261376 B CN108261376 B CN 108261376B CN 201810181620 A CN201810181620 A CN 201810181620A CN 108261376 B CN108261376 B CN 108261376B
- Authority
- CN
- China
- Prior art keywords
- malt
- parts
- filtering
- moisturizing factor
- powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000003020 moisturizing effect Effects 0.000 title claims abstract description 94
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 56
- 229920002674 hyaluronan Polymers 0.000 claims abstract description 31
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 30
- 229960003160 hyaluronic acid Drugs 0.000 claims abstract description 30
- WQXNXVUDBPYKBA-YFKPBYRVSA-N ectoine Chemical compound CC1=[NH+][C@H](C([O-])=O)CCN1 WQXNXVUDBPYKBA-YFKPBYRVSA-N 0.000 claims abstract description 27
- 150000001720 carbohydrates Chemical class 0.000 claims abstract description 25
- 108010020346 Polyglutamic Acid Proteins 0.000 claims abstract description 24
- 239000002253 acid Substances 0.000 claims abstract description 22
- 229920000370 gamma-poly(glutamate) polymer Polymers 0.000 claims abstract description 22
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims abstract description 21
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 21
- 125000002801 octanoyl group Chemical group C(CCCCCCC)(=O)* 0.000 claims abstract description 21
- 239000011734 sodium Substances 0.000 claims abstract description 21
- 229910052708 sodium Inorganic materials 0.000 claims abstract description 21
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 21
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 21
- 229940015975 1,2-hexanediol Drugs 0.000 claims abstract description 20
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims abstract description 20
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 94
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 claims description 84
- 239000000843 powder Substances 0.000 claims description 79
- 239000000706 filtrate Substances 0.000 claims description 61
- 238000001914 filtration Methods 0.000 claims description 61
- 239000000047 product Substances 0.000 claims description 56
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 48
- 238000003756 stirring Methods 0.000 claims description 32
- 238000002156 mixing Methods 0.000 claims description 31
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 30
- 239000012752 auxiliary agent Substances 0.000 claims description 30
- 238000001035 drying Methods 0.000 claims description 30
- 239000002994 raw material Substances 0.000 claims description 19
- 238000002360 preparation method Methods 0.000 claims description 18
- 238000009210 therapy by ultrasound Methods 0.000 claims description 16
- 238000005303 weighing Methods 0.000 claims description 16
- 230000001678 irradiating effect Effects 0.000 claims description 15
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 claims description 15
- 229910052753 mercury Inorganic materials 0.000 claims description 15
- 239000004408 titanium dioxide Substances 0.000 claims description 15
- 238000000874 microwave-assisted extraction Methods 0.000 claims description 14
- WQXNXVUDBPYKBA-UHFFFAOYSA-N Ectoine Natural products CC1=NCCC(C(O)=O)N1 WQXNXVUDBPYKBA-UHFFFAOYSA-N 0.000 claims description 13
- APZYKUZPJCQGPP-UHFFFAOYSA-N Tetrahydropiperine Chemical compound C=1C=C2OCOC2=CC=1CCCCC(=O)N1CCCCC1 APZYKUZPJCQGPP-UHFFFAOYSA-N 0.000 claims description 4
- 239000000126 substance Substances 0.000 abstract description 18
- 210000003491 skin Anatomy 0.000 description 85
- 230000000052 comparative effect Effects 0.000 description 44
- 239000002537 cosmetic Substances 0.000 description 43
- 238000000034 method Methods 0.000 description 28
- 238000012360 testing method Methods 0.000 description 14
- 239000006210 lotion Substances 0.000 description 11
- 239000006071 cream Substances 0.000 description 10
- 230000035784 germination Effects 0.000 description 10
- 241000209219 Hordeum Species 0.000 description 9
- 235000007340 Hordeum vulgare Nutrition 0.000 description 9
- 230000000694 effects Effects 0.000 description 9
- 230000001815 facial effect Effects 0.000 description 8
- 239000007788 liquid Substances 0.000 description 7
- 238000010521 absorption reaction Methods 0.000 description 6
- 230000006870 function Effects 0.000 description 6
- 210000000434 stratum corneum Anatomy 0.000 description 6
- 208000002874 Acne Vulgaris Diseases 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 5
- 206010000496 acne Diseases 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 5
- 230000014759 maintenance of location Effects 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 102000004169 proteins and genes Human genes 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 210000004207 dermis Anatomy 0.000 description 4
- 230000006866 deterioration Effects 0.000 description 4
- 229940094944 saccharide isomerate Drugs 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 239000000516 sunscreening agent Substances 0.000 description 4
- 229920001503 Glucan Polymers 0.000 description 3
- 206010020751 Hypersensitivity Diseases 0.000 description 3
- 208000026935 allergic disease Diseases 0.000 description 3
- 230000007815 allergy Effects 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000000284 extract Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 230000002829 reductive effect Effects 0.000 description 3
- 230000000475 sunscreen effect Effects 0.000 description 3
- 230000002087 whitening effect Effects 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 206010013786 Dry skin Diseases 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Chemical group CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 description 2
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical group CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 description 2
- MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Chemical group CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 229930013930 alkaloid Natural products 0.000 description 2
- 150000003797 alkaloid derivatives Chemical class 0.000 description 2
- AEMOLEFTQBMNLQ-WAXACMCWSA-N alpha-D-glucuronic acid Chemical group O[C@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-WAXACMCWSA-N 0.000 description 2
- 230000003385 bacteriostatic effect Effects 0.000 description 2
- 230000003796 beauty Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 235000013339 cereals Nutrition 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 230000018044 dehydration Effects 0.000 description 2
- 238000006297 dehydration reaction Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 230000037336 dry skin Effects 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- KUBCEEMXQZUPDQ-UHFFFAOYSA-N hordenine Chemical compound CN(C)CCC1=CC=C(O)C=C1 KUBCEEMXQZUPDQ-UHFFFAOYSA-N 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 239000002932 luster Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 229950006780 n-acetylglucosamine Drugs 0.000 description 2
- 229920002643 polyglutamic acid Polymers 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 210000004927 skin cell Anatomy 0.000 description 2
- 238000013112 stability test Methods 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000000346 sugar Nutrition 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 229920002498 Beta-glucan Polymers 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 208000032544 Cicatrix Diseases 0.000 description 1
- LKDRXBCSQODPBY-JDJSBBGDSA-N D-allulose Chemical compound OCC1(O)OC[C@@H](O)[C@@H](O)[C@H]1O LKDRXBCSQODPBY-JDJSBBGDSA-N 0.000 description 1
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
- 208000001840 Dandruff Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- 102000011782 Keratins Human genes 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 244000062730 Melissa officinalis Species 0.000 description 1
- 235000010654 Melissa officinalis Nutrition 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000013566 allergen Substances 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 229920001222 biopolymer Polymers 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000019522 cellular metabolic process Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000000536 complexating effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 235000013325 dietary fiber Nutrition 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 150000002016 disaccharides Chemical group 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 210000001339 epidermal cell Anatomy 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 210000001723 extracellular space Anatomy 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 229930182830 galactose Natural products 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- ACCCMOQWYVYDOT-UHFFFAOYSA-N hexane-1,1-diol Chemical compound CCCCCC(O)O ACCCMOQWYVYDOT-UHFFFAOYSA-N 0.000 description 1
- 229940071490 hordenine Drugs 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 125000001841 imino group Chemical group [H]N=* 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 239000000865 liniment Substances 0.000 description 1
- 210000000088 lip Anatomy 0.000 description 1
- 239000012263 liquid product Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004890 malting Methods 0.000 description 1
- 210000001161 mammalian embryo Anatomy 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 210000000282 nail Anatomy 0.000 description 1
- 235000013557 nattō Nutrition 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000037387 scars Effects 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- PVGBHEUCHKGFQP-UHFFFAOYSA-N sodium;n-[5-amino-2-(4-aminophenyl)sulfonylphenyl]sulfonylacetamide Chemical compound [Na+].CC(=O)NS(=O)(=O)C1=CC(N)=CC=C1S(=O)(=O)C1=CC=C(N)C=C1 PVGBHEUCHKGFQP-UHFFFAOYSA-N 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/88—Polyamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to the field of daily chemical products, in particular to a three-dimensional moisturizing factor. The three-dimensional moisturizing factor comprises, by weight, 30 parts of saccharide isomer, 5-12 parts of ectoin, 1-5 parts of malt extract, 0.1-1.5 parts of caprylyl hydroximic acid, 0.1-0.4 part of 1, 2-hexanediol, 0.1-0.5 part of sodium polyglutamate, 0.01-0.5 part of hyaluronic acid, 0.01-0.1 part of sodium hyaluronate and 68-80 parts of water.
Description
Technical Field
The invention relates to the field of daily chemical products, in particular to a three-dimensional moisturizing factor.
Background
The development of the modern times and the innovation and progress of the technology lead the cosmetic industry to develop rapidly, meanwhile, the requirements of people on the cosmetic products are continuously improved, and the cosmetic products with various functions, dosage forms and unique appearances attract the eyes of consumption. The cosmetic is a product which is applied to any part of the human body surface (such as skin, nail, lip, oral cavity, etc.) by smearing, spraying or other similar methods, so as to achieve the purposes of cleaning, eliminating bad smell, caring skin, beautifying and decorating, etc. When the air temperature is reduced, the skin cuticle can not timely regulate enough moisturizing factors, the activity of the oil glands is reduced, the oil and water on the face are reduced, the skin can be tightened, and fine wrinkles are even formed below the eyes and around the nose. The skin contains 18-20% of water in the whole body, the water in the skin is mainly concentrated in the dermis, and under the normal condition, the water content of the stratum corneum of women accounts for more than about 20% of the water content of the skin, and the rest is in the dermis. The moisture content of the stratum corneum is determined by skin feel, luster and the like, but the moisture content of the dermis is a reliable source for providing the moisture content of the stratum corneum, and the stratum corneum is close to and inseparable. When the water content of the stratum corneum is low, the dry skin can be transformed. Dry skin has a series of problems such as rough skin, more dandruff, thin horny layer, weak skin allergy resistance, more fine lines and the like.
With the development of the beauty cosmetics industry, natural plant products are welcomed due to the advantages of safe use, mild action, obvious effect and the like. The plant extract containing effective components is obtained by corresponding processing, and is added into cosmetics. In addition, the moisture-retaining cosmetics also need to achieve the function of rapidly moisturizing the skin and unique fresh and moist skin feel. At present, in order to increase the moisturizing function of the cosmetics, a large amount of moisture absorbents such as hyaluronic acids and biological fermentation polysaccharides are added to the products on the market, however, if the usage amount is too large, the skin feel is greasy and not fresh, and if the usage amount is low, the moisturizing effect is not obvious, and the moisturizing effect is almost different from that of common purified water. Moreover, the current moisturizing cosmetics on the market are very easy to cause phenomena of allergy, easy mildew and deterioration, poor stability and the like. Therefore, it is an urgent problem to select which plant to safely apply to cosmetics to achieve better moisturizing effect.
Disclosure of Invention
In order to solve the technical problems, the first aspect of the invention provides a three-dimensional moisturizing factor, which comprises, by weight, 30 parts of saccharide isomer, 5-12 parts of ectoin, 1-5 parts of malt extract, 0.1-1.5 parts of caprylyl hydroximic acid, 0.1-0.4 part of 1, 2-hexanediol, 0.1-0.5 part of sodium polyglutamate, 0.01-0.2 part of hyaluronic acid, 0.01-0.1 part of sodium hyaluronate and 68-80 parts of water.
As a preferable technical scheme, the three-dimensional moisturizing factor comprises, by weight, 30 parts of saccharide isomer, 8 parts of ectoin, 2 parts of malt extract, 0.64 parts of caprylyl hydroximic acid, 0.16 parts of 1,2 parts of hexanediol, 0.2 parts of sodium polyglutamate, 0.05 parts of hyaluronic acid, 0.02 parts of sodium hyaluronate and 75 parts of water.
As a preferred technical scheme, the preparation method of the malt extract comprises the following steps:
(1) selecting malt which germinates for 2 days and 6 days as a raw material, and crushing;
(2) weighing 10g of crushed malt, adding 120ml of 25 wt% ethanol, stirring and mixing, performing ultrasonic treatment for 10 minutes, stirring and extracting at 75 ℃ for 3 hours, filtering and collecting filtrate; adding 0.03g of titanium dioxide powder into the obtained filtrate, irradiating for 15 seconds under a low-pressure mercury lamp, filtering, collecting the filtrate, concentrating, and drying to obtain powder A;
(3) adding 60ml of 70 wt% ethanol and 2g of auxiliary agent into the filter residue obtained by filtering in the step (2), performing microwave extraction for 45min under 480W power, filtering, collecting filtrate, concentrating, and drying to obtain powder B;
(4) mixing powder B and powder A in a ratio of 1: 1.5-3.5 by weight ratio to obtain the malt extract.
In a preferred embodiment, the malt is germinated in the malt for 2 days in an amount of 30 to 40% by weight based on the total weight of the malt.
As a preferred technical solution, the weight ratio of the B powder to the a powder in the malt extract is 1: 2.8.
as a preferable technical scheme, the auxiliary agent is glycerol and/or tetrahydropiperine.
The second aspect of the invention provides the application of the three-dimensional moisturizing factor, which is applied to the field of skin care products.
A third aspect of the present invention provides a skin care product comprising the three-dimensional moisturizing factor as described above.
The fourth aspect of the present invention provides a malt extract produced by the production method described above.
In a fifth aspect of the present invention, there is provided a use of the malt extract as described above in preparing a skin care product having whitening and/or moisturizing effects.
Has the advantages that: the raw materials for preparing the three-dimensional moisturizing factor provided by the invention are environment-friendly and pollution-free, and have no stimulation and allergy to human skin. In addition, the three-dimensional moisturizing factor provided by the application has very light moisturizing capability, can supplement the required moisture for the skin, can lock the moisture at the same time, avoids the loss of the moisture, keeps the skin moist and fresh, and is more elastic. Moreover, the three-dimensional moisturizing factor provided by the application has good stability while having strong moisturizing capability, and the components in the three-dimensional moisturizing factor have self-carried bacteriostatic performance, so that the long-term stable preservation of the product can be guaranteed without adding an extra preservative.
Detailed Description
The disclosure may be understood more readily by reference to the following detailed description of preferred embodiments of the invention and the examples included therein. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In case of conflict, the present specification, including definitions, will control.
The term "prepared from …" as used herein is synonymous with "comprising". The terms "comprises," "comprising," "includes," "including," "has," "having," "contains," "containing," or any other variation thereof, as used herein, are intended to cover a non-exclusive inclusion. For example, a composition, process, method, article, or apparatus that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, process, method, article, or apparatus.
The conjunction "consisting of …" excludes any unspecified elements, steps or components. If used in a claim, the phrase is intended to claim as closed, meaning that it does not contain materials other than those described, except for the conventional impurities associated therewith. When the phrase "consisting of …" appears in a clause of the subject matter of the claims rather than immediately after the subject matter, it defines only the elements described in the clause; other elements are not excluded from the claims as a whole.
When an amount, concentration, or other value or parameter is expressed as a range, preferred range, or as a range of upper preferable values and lower preferable values, this is to be understood as specifically disclosing all ranges formed from any pair of any upper range limit or preferred value and any lower range limit or preferred value, regardless of whether ranges are separately disclosed. For example, when a range of "1 to 5" is disclosed, the described range should be interpreted to include the ranges "1 to 4", "1 to 3", "1 to 2 and 4 to 5", "1 to 3 and 5", and the like. When a range of values is described herein, unless otherwise stated, the range is intended to include the endpoints thereof and all integers and fractions within the range.
The singular forms "a", "an" and "the" include plural referents unless the context clearly dictates otherwise. "optional" or "any" means that the subsequently described event or events may or may not occur, and that the description includes instances where the event occurs and instances where it does not.
Approximating language, as used herein throughout the specification and claims, is intended to modify a quantity, such that the invention is not limited to the specific quantity, but includes portions that are literally received for modification without substantial change in the basic function to which the invention is related. Accordingly, the use of "about" to modify a numerical value means that the invention is not limited to the precise value. In some instances, the approximating language may correspond to the precision of an instrument for measuring the value. In the present description and claims, range limitations may be combined and/or interchanged, including all sub-ranges contained therein if not otherwise stated.
In addition, the indefinite articles "a" and "an" preceding an element or component of the invention are not intended to limit the number requirement (i.e., the number of occurrences) of the element or component. Thus, "a" or "an" should be read to include one or at least one, and the singular form of an element or component also includes the plural unless the stated number clearly indicates that the singular form is intended.
In order to solve the above technical problems, the first aspect of the present invention provides a three-dimensional moisturizing factor, which comprises, by weight, 30 parts of saccharide isomer, 5 to 12 parts of ectoin, 1 to 5 parts of malt extract, 0.1 to 1.5 parts of caprylyl hydroximic acid, 0.1 to 0.4 part of 1, 2-hexanediol, 0.1 to 0.5 part of sodium polyglutamate, 0.01 to 0.2 part of hyaluronic acid, 0.01 to 0.1 part of sodium hyaluronate, and 68 to 80 parts of water.
In a preferred embodiment, the three-dimensional moisturizing factor comprises, by weight, saccharide isomer 30, ectoin 8, malt extract 2, caprylyl hydroximic acid 0.64, 1,2 hexanediol 0.16, sodium polyglutamate 0.2, hyaluronic acid 0.05, sodium hyaluronate 0.02, and water 75.
The saccharide isomerate (saccharide isomerate) in the present invention is a colorless or yellowish transparent liquid, a carbohydrate extracted from a sucrose-based complex, and contains chemical components similar to skin components, such as glucose, fructose, lactose products, mannose, galactose, psicose, etc.
The saccharide isomerate has a composition structure similar to human horny layer, assists water to combine with keratin in the horny layer to achieve the moisturizing effect, is a good water-retaining agent and emollient, and has the functions of repairing epidermal cells and improving the water-replenishing capacity of skin. For example, when the isomerized D-glucan is used on the skin, the isomerized D-glucan can be combined with epsilon-amino acid functional groups, so that the isomerized D-glucan is firmly combined like a magnet, and the water magnetic field capability of the skin can be maintained for a long time. The saccharide isomer in the present invention can be purchased from the market, and preferably selected from the netherlands DSM chemical saccharide isomer having a remarkable moisturizing effect, under the trade name of PENTAVITIN.
The ectoin is named 2-methyl-1, 4,5, 6-tetrahydropyrimidine-4-carboxylic acid in chemical name, and has excellent water molecule complexing capacity due to the unique three-dimensional molecular structure, one molecule of ectoin can complex four or five water molecules, and free water in skin cells can be structured under the interaction with other components provided by the application, so that the moisture retention capacity of the skin is continuously improved. In addition, ectoin is beneficial to balancing osmotic pressure, and dehydration and death of high halophilic bacteria and the like in the skin under a high-salt environment are avoided. Secondly, the ectoin can effectively improve the immune protection capability of skin cells and increase the cell repair capability under the synergistic action of the ectoin, saccharide isomer, hyaluronic acid and other components, so that the skin can effectively resist the invasion of microorganisms and allergens and relieve various damages to the skin, such as skin aging caused by ultraviolet damage and dry environment, skin deterioration caused by surfactant and the like. Ectoin in the present invention was purchased from merck chemical technology limited, germany.
The caprylyl hydroximic acid and the 1,2 hexanediol in the invention have good compatibilization, solubilization and whitening effects, and are purchased from Germany Merck chemical technology Limited company. The sodium polyglutamate is the sodium salt of polyglutamic acid, which is also called natto gum and polyglutamic acid, and is a water-soluble, biodegradable and nontoxic biopolymer. Due to functional groups such as imino, carboxyl and the like and special molecular structures on the structure, the water-absorbing and moisturizing skin care lotion has the synergistic effect with components such as hyaluronic acid, sodium hyaluronate, ectoin and the like, so that the skin becomes tender, smooth and elastic, and the health of the skin is promoted. Hyaluronic acid is an acidic mucopolysaccharide, also known as hyaluronic acid, a higher polysaccharide composed of units of D-glucuronic acid and N-acetylglucosamine. D-glucuronic acid and N-acetylglucosamine are connected by beta-1, 3-glycosidic bond, and disaccharide units are connected by beta-1, 4-glycosidic bond. Hyaluronic acid is one of main matrix components of human skin epidermis and dermis, can enable water to enter intercellular spaces and combine with protein to form protein gel, adhere cells together, play a role in normal cell metabolism, keep cell water, protect cells from being invaded by pathogenic bacteria, accelerate recovery of skin tissues, restore original smoothness and elasticity of skin, improve wound healing regeneration capacity, reduce scars, enhance immunity and the like.
The applicant finds that hyaluronic acid has strong water absorption and moisture retention capacity, but when added into skin care products, the hyaluronic acid is easy to mildew and deteriorate under the action of harmful bacteria in the environment, and the stability and the shelf life of the skin care products are seriously influenced. Further, the applicant has found that although components such as sodium polyglutamate, saccharide isomerate and hyaluronic acid have a strong water absorbing capacity and can make skin tender and elastic, the water absorbed by these components is lost, and particularly, the skin becomes water-deficient and loses luster as the components are metabolized.
The malt extract in the invention is a product obtained by extracting barley malt obtained by germinating barley seeds according to the preparation method provided by the application. Barley malt mainly contains protein, fat, starch, amino acids, reducing sugar, beta-glucan, soluble (insoluble) dietary fiber, vitamins, iron, phosphorus, calcium and other acid components. Barley seeds contain a large amount of macromolecular organic substances containing nitrogen, carbon and the like, such as proteins and starch, and during the germination of barley seeds, the organic substances are decomposed or degraded by various enzymes and the like to generate low-molecular-weight peptides, amino acids, sugars and other components, and the components are used for providing nutrient substances for the germination of seeds. Thus, the barley seeds are decomposed, new chemical components are generated and consumed, and the like, at the moment during the germination process, and thus the malt material selected for extraction in the present invention has a high requirement for the germination time.
In a preferred embodiment, the method for preparing the malt extract comprises the steps of:
(1) selecting malt which germinates for 2 days and 6 days as a raw material, and crushing;
(2) weighing 10g of crushed malt, adding 120ml of 25 wt% ethanol, stirring and mixing, performing ultrasonic treatment for 10 minutes, stirring and extracting at 75 ℃ for 3 hours, filtering and collecting filtrate; adding 0.03g of titanium dioxide powder into the obtained filtrate, irradiating for 15 seconds under a low-pressure mercury lamp, filtering, collecting the filtrate, concentrating, and drying to obtain powder A;
(3) adding 60ml of 70 wt% ethanol and 2g of auxiliary agent into the filter residue obtained by filtering in the step (2), performing microwave extraction for 45min under 480W power, filtering, collecting filtrate, concentrating, and drying to obtain powder B;
(4) mixing powder B and powder A in a ratio of 1: 1.5-3.5 by weight ratio to obtain the malt extract.
The applicant finds that when the malt with too short germination time is selected, the large molecular components such as protein and fat are more in the malt, the effective components obtained by decomposition and degradation are less, while when the malt with too long germination time is selected, the large molecular components are less, and the components such as hordenine and trichosanthene in the extract obtained by extraction are correspondingly increased, so that the moisture absorption and retention capacity is improved, and the skin can be stimulated and toxic and side effects are generated on the skin. Because the barley seed structure is different from wheat, oat and the like, and the embryo, endosperm and other structures are also different, chemical components contained in the barley seed, and new amino acids, saccharides and other components generated in the germination process are also different from other cereals, so that the components and the effects of the extract extracted from the seeds germinated by different cereals are different from the components provided by the application. The effect of the malt extract extracted from the barley malt with different germination time in the moisture factor is also greatly different. The extract obtained by extracting mixed malt with germination time of 2 days and germination time of 6 days as raw material has the best effects of absorbing water and locking water.
In a preferred embodiment, the weight of the malt malting for 2 days in the malt represents 30% to 40% of the total malt weight.
In a preferred embodiment, the weight ratio of the B powder to the a powder in the malt extract is 1: 2.8.
the applicant also finds that the malt extract extracted by the method provided by the application is compounded with other components of the three-dimensional moisturizing factor provided by the application, so that the moisturizing capability and the stability of the three-dimensional moisturizing factor can be improved, and the shelf life of the three-dimensional moisturizing factor is not influenced even if a proper amount of components such as hyaluronic acid which is easy to deteriorate and mildew are added into the malt extract. In actual production, some components with strong water absorption are required to be added in order to improve the water absorption capacity of the moisturizing product, but the addition of the components causes other adverse effects, such as that the product is easy to become unstable and easy to go moldy and deteriorate while the water absorption capacity of the product is improved. The three-dimensional moisturizing factor provided by the application has good bacteriostatic performance and solves the problem. The possible reason why the three-dimensional moisturizing factor provided by the application has antibacterial activity is that the malt extract prepared by the method provided by the application contains some antibacterial components to inhibit the proliferation and differentiation of harmful bacteria, or the malt extract contains compounds with partial hydrophilic macromolecular structures, the film forming capability is strong, and the three-dimensional moisturizing factor can form a water absorbing film in a three-dimensional network state while absorbing water and replenishing water in the use process, so that the moisture is kept, the loss of the moisture is avoided, components such as hyaluronic acid and the like which are easy to breed harmful bacteria are coated, the mildew and deterioration of the components are avoided, the stability is improved, and the shelf life is prolonged.
In a preferred embodiment, the adjuvant is glycerol and/or tetrahydropiperine. The auxiliary agent in the invention interacts with the microwave to promote the penetration of the solvent into the cells in the malt and improve the dissolution of the effective components in the malt. When the auxiliary agent is glycerol and tetrahydrozanthoxylum alkaloid, no special requirement is required on the weight ratio of the auxiliary agent, wherein the tetrahydrozanthoxylum alkaloid can be purchased from Nanjing Dow Biotech limited.
The invention provides the application of the three-dimensional moisturizing factor as claimed in any one of claims 1 to 6 in the field of skin care products.
In a third aspect, the present invention provides a skin care product comprising the three-dimensional moisturizing factor according to any one of claims 1 to 6.
In a fourth aspect of the present invention, there is provided a malt extract produced by the production method according to claim 4.
In a fifth aspect of the present invention, there is provided a use of the malt extract according to claim 9 in preparing a skin care product having whitening and/or moisturizing effects.
In the present invention, the skin care product may be any form of cosmetic known to those skilled in the art, including, but not limited to, a water aqua, an emulsion, a cream, an eye cream, a face cleanser, a mask, a BB cream, a skin lotion, a sunscreen cream, a sunscreen lotion, an acne lotion, a face cleaning lotion, an essential oil, a shampoo, a moisturizer, a toner, a astringent lotion, and a toner. The lotion and the cream are liquid cream cosmetics. The facial cleanser, the facial water and the facial lotion generally refer to liquid products composed of oil phase substances, water phase substances, surfactants, humectants, nutritional agents and the like, and include but are not limited to facial cleanser, facial cream and skin lotion. The facial mask is a carrier of beauty care products, and comprises but is not limited to a paste type, a tearing type, a jelly type and a wet tissue type facial mask. The BB cream refers to Blemish Balm, and has the effects of concealing blemishes, adjusting skin color, preventing sun and refining pores. The pure liquid refers to a liquid containing concentrated high-nutrition substances, and includes but is not limited to the forms of essence liquid, essence lotion, essence facial mask, essence injection, essence capsule and the like. The sunscreen cream is a cosmetic which is added with a sunscreen agent capable of blocking or absorbing ultraviolet rays to prevent skin from being sunburned and sunburned. The acne water is a liquid substance with the effect of treating acne. The acne lotion is a liquid substance with the function of treating acne.
The present invention will be specifically described below by way of examples. It should be noted that the following examples are only for illustrating the present invention and should not be construed as limiting the scope of the present invention, and that the insubstantial modifications and adaptations of the present invention by those skilled in the art based on the above disclosure are still within the scope of the present invention.
In addition, the raw materials used are commercially available from national chemical reagents, unless otherwise specified.
Examples
Example 1
Example 1 provides a three-dimensional moisturizing factor including, in parts by weight, saccharide isomer 30, ectoin 5, malt extract 1, caprylyl hydroximic acid 0.1, 1,2 hexanediol 0.1, sodium polyglutamate 0.1, hyaluronic acid 0.01, sodium hyaluronate 0.01, and water 68.
The preparation method of the malt extract comprises the following steps:
(1) selecting malt which germinates for 2 days and 6 days as a raw material, and crushing;
(2) weighing 10g of crushed malt, adding 120ml of 25 wt% ethanol, stirring and mixing, performing ultrasonic treatment for 10 minutes, stirring and extracting at 75 ℃ for 3 hours, filtering and collecting filtrate; adding 0.03g of titanium dioxide powder into the obtained filtrate, irradiating for 15 seconds under a low-pressure mercury lamp, filtering, collecting the filtrate, concentrating, and drying to obtain powder A;
(3) adding 60ml of 70 wt% ethanol and 2g of auxiliary agent into the filter residue obtained by filtering in the step (2), performing microwave extraction for 45min under 480W power, filtering, collecting filtrate, concentrating, and drying to obtain powder B;
(4) mixing powder B and powder A in a ratio of 1: 1.5 by weight ratio to obtain the malt extract.
The auxiliary agent is glycerol; the weight of malt germinated for 2 days in the malt accounted for 30% of the total malt weight.
The embodiment also provides a skin care product, wherein the skin care product is a cosmetic purchased at any place on the market and then is matched with the three-dimensional moisturizing factor provided by the embodiment for use. The specific application method is that 3 parts of commercially available cosmetics are mixed with 0.5 part of the three-dimensional moisturizing factor provided by the embodiment for use.
Example 2
Embodiment 2 provides a three-dimensional moisturizing factor, which includes, in parts by weight, saccharide isomer 30, ectoin 12, malt extract 5, caprylyl hydroximic acid 1.5, 1,2 hexanediol 0.4, sodium polyglutamate 0.5, hyaluronic acid 0.2, sodium hyaluronate 0.5, and water 80.
The preparation method of the malt extract comprises the following steps:
(1) selecting malt which germinates for 2 days and 6 days as a raw material, and crushing;
(2) weighing 10g of crushed malt, adding 120ml of 25 wt% ethanol, stirring and mixing, performing ultrasonic treatment for 10 minutes, stirring and extracting at 75 ℃ for 3 hours, filtering and collecting filtrate; adding 0.03g of titanium dioxide powder into the obtained filtrate, irradiating for 15 seconds under a low-pressure mercury lamp, filtering, collecting the filtrate, concentrating, and drying to obtain powder A;
(3) adding 60ml of 70 wt% ethanol and 2g of auxiliary agent into the filter residue obtained by filtering in the step (2), performing microwave extraction for 45min under 480W power, filtering, collecting filtrate, concentrating, and drying to obtain powder B;
(4) mixing powder B and powder A in a ratio of 1: 3.5 by weight ratio to obtain the malt extract.
The auxiliary agent is glycerol; the weight of malt germinated for 2 days in the malt accounted for 40% of the total malt weight.
The embodiment also provides a skin care product, wherein the skin care product is a cosmetic purchased at any place on the market and then is matched with the three-dimensional moisturizing factor provided by the embodiment for use. The specific application method is that 3 parts of commercially available cosmetics are mixed with 0.5 part of the three-dimensional moisturizing factor provided by the embodiment for use.
Example 3
Embodiment 3 provides a three-dimensional moisturizing factor, which includes, in parts by weight, saccharide isomer 30, ectoine 8, malt extract 2, caprylyl hydroximic acid 0.64, 1,2 hexanediol 0.16, sodium polyglutamate 0.2, hyaluronic acid 0.05, sodium hyaluronate 0.02, and water 75.
The preparation method of the malt extract comprises the following steps:
(1) selecting malt which germinates for 2 days and 6 days as a raw material, and crushing;
(2) weighing 10g of crushed malt, adding 120ml of 25 wt% ethanol, stirring and mixing, performing ultrasonic treatment for 10 minutes, stirring and extracting at 75 ℃ for 3 hours, filtering and collecting filtrate; adding 0.03g of titanium dioxide powder into the obtained filtrate, irradiating for 15 seconds under a low-pressure mercury lamp, filtering, collecting the filtrate, concentrating, and drying to obtain powder A;
(3) adding 60ml of 70 wt% ethanol and 2g of auxiliary agent into the filter residue obtained by filtering in the step (2), performing microwave extraction for 45min under 480W power, filtering, collecting filtrate, concentrating, and drying to obtain powder B;
(4) mixing powder B and powder A in a ratio of 1: 2.8 by weight ratio to obtain the malt extract.
The auxiliary agent is glycerol; the weight of the malt germinated for 2 days in the malt accounted for 38% of the total malt weight.
The embodiment also provides a skin care product, wherein the skin care product is a cosmetic purchased at any place on the market and then is matched with the three-dimensional moisturizing factor provided by the embodiment for use. The specific application method is that 3 parts of commercially available cosmetics are mixed with 0.5 part of the three-dimensional moisturizing factor provided by the embodiment for use.
Example 4
Embodiment 4 provides a three-dimensional moisturizing factor, which includes, in parts by weight, saccharide isomer 30, ectoine 8, malt extract 2, caprylyl hydroximic acid 0.64, 1,2 hexanediol 0.16, sodium polyglutamate 0.2, hyaluronic acid 0.05, sodium hyaluronate 0.02, and water 75.
The preparation method of the malt extract comprises the following steps:
(1) selecting malt which germinates for 2 days and 6 days as a raw material, and crushing;
(2) weighing 10g of crushed malt, adding 120ml of 25 wt% ethanol, stirring and mixing, performing ultrasonic treatment for 10 minutes, stirring and extracting at 75 ℃ for 3 hours, filtering and collecting filtrate; adding 0.03g of titanium dioxide powder into the obtained filtrate, irradiating for 15 seconds under a low-pressure mercury lamp, filtering, collecting the filtrate, concentrating, and drying to obtain powder A;
(3) adding 60ml of 70 wt% ethanol and 2g of auxiliary agent into the filter residue obtained by filtering in the step (2), performing microwave extraction for 45min under 480W power, filtering, collecting filtrate, concentrating, and drying to obtain powder B;
(4) mixing powder B and powder A in a ratio of 1: 2.8 by weight ratio to obtain the malt extract.
The auxiliary agent is tetrahydropiperine; the weight of the malt germinated for 2 days in the malt accounted for 38% of the total malt weight.
The embodiment also provides a skin care product, wherein the skin care product is a cosmetic purchased at any place on the market and then is matched with the three-dimensional moisturizing factor provided by the embodiment for use. The specific application method is that 3 parts of commercially available cosmetics are mixed with 0.5 part of the three-dimensional moisturizing factor provided by the embodiment for use.
Comparative example 1
Comparative example 1 provides a three-dimensional moisturizing factor comprising, in parts by weight, saccharide isomer 30, ectoine 8, malt extract 2, caprylyl hydroximic acid 0.64, 1,2 hexanediol 0.16, sodium polyglutamate 0.2, hyaluronic acid 0.5, sodium hyaluronate 0.02, water 75.
The preparation method of the malt extract comprises the following steps:
(1) selecting malt which germinates for 2 days and 6 days as a raw material, and crushing;
(2) weighing 10g of crushed malt, adding 120ml of 25 wt% ethanol, stirring and mixing, performing ultrasonic treatment for 10 minutes, stirring and extracting at 75 ℃ for 3 hours, filtering and collecting filtrate; adding 0.03g of titanium dioxide powder into the obtained filtrate, irradiating for 15 seconds under a low-pressure mercury lamp, filtering, collecting the filtrate, concentrating, and drying to obtain powder A;
(3) adding 60ml of 70 wt% ethanol and 2g of auxiliary agent into the filter residue obtained by filtering in the step (2), performing microwave extraction for 45min under 480W power, filtering, collecting filtrate, concentrating, and drying to obtain powder B;
(4) mixing powder B and powder A in a ratio of 1: 2.8 by weight ratio to obtain the malt extract.
The auxiliary agent is glycerol; the weight of the malt germinated for 2 days in the malt accounted for 38% of the total malt weight.
The embodiment also provides a skin care product, wherein the skin care product is a cosmetic purchased at any place on the market and then is matched with the three-dimensional moisturizing factor provided by the embodiment for use. The specific application method is that 3 parts of commercially available cosmetics are mixed with 0.5 part of the three-dimensional moisturizing factor provided by the embodiment for use.
Comparative example 2
Comparative example 2 provides a three-dimensional moisturizing factor comprising, in parts by weight, saccharide isomer 30, ectoine 8, caprylyl hydroximic acid 0.64, 1,2 hexanediol 0.16, sodium polyglutamate 0.2, hyaluronic acid 0.05, sodium hyaluronate 0.02, water 75.
The preparation method of the malt extract comprises the following steps:
(1) selecting malt which germinates for 2 days and 6 days as a raw material, and crushing;
(2) weighing 10g of crushed malt, adding 120ml of 25 wt% ethanol, stirring and mixing, performing ultrasonic treatment for 10 minutes, stirring and extracting at 75 ℃ for 3 hours, filtering and collecting filtrate; adding 0.03g of titanium dioxide powder into the obtained filtrate, irradiating for 15 seconds under a low-pressure mercury lamp, filtering, collecting the filtrate, concentrating, and drying to obtain powder A;
(3) adding 60ml of 70 wt% ethanol and 2g of auxiliary agent into the filter residue obtained by filtering in the step (2), performing microwave extraction for 45min under 480W power, filtering, collecting filtrate, concentrating, and drying to obtain powder B;
(4) mixing powder B and powder A in a ratio of 1: 2.8 by weight ratio to obtain the malt extract.
The auxiliary agent is glycerol; the weight of the malt germinated for 2 days in the malt accounted for 38% of the total malt weight.
The present example also provides a skin care product, which is a cosmetic product (same as example 1) purchased from any market, and then used in combination with the three-dimensional moisturizing factor provided in the present example. The specific application method is that 3 parts of commercially available cosmetics are mixed with 0.5 part of the three-dimensional moisturizing factor provided by the embodiment for use.
Comparative example 3
Comparative example 3 provides a three-dimensional moisturizing factor comprising, in parts by weight, saccharide isomer 30, ectoine 8, malt extract 2, caprylyl hydroximic acid 0.64, 1,2 hexanediol 0.16, sodium polyglutamate 0.2, hyaluronic acid 0.05, sodium hyaluronate 0.02, water 75.
The preparation method of the malt extract comprises the following steps:
(1) selecting malt which germinates for 2 days as a raw material, and crushing;
(2) weighing 10g of crushed malt, adding 120ml of 25 wt% ethanol, stirring and mixing, performing ultrasonic treatment for 10 minutes, stirring and extracting at 75 ℃ for 3 hours, filtering and collecting filtrate; adding 0.03g of titanium dioxide powder into the obtained filtrate, irradiating for 15 seconds under a low-pressure mercury lamp, filtering, collecting the filtrate, concentrating, and drying to obtain powder A;
(3) adding 60ml of 70 wt% ethanol and 2g of auxiliary agent (glycerol) into the filter residue obtained by filtering in the step (2), performing microwave extraction for 45min under 480W power, filtering, collecting filtrate, concentrating, and drying to obtain powder B;
(4) mixing powder B and powder A in a ratio of 1: 2.8 by weight ratio to obtain the malt extract.
The present example also provides a skin care product, which is a cosmetic product (same as example 1) purchased from any market, and then used in combination with the three-dimensional moisturizing factor provided in the present example. The specific application method is that 3 parts of commercially available cosmetics are mixed with 0.5 part of the three-dimensional moisturizing factor provided by the embodiment for use.
Comparative example 4
Comparative example 4 provides a three-dimensional moisturizing factor comprising, in parts by weight, saccharide isomer 30, ectoine 8, malt extract 2, caprylyl hydroximic acid 0.64, 1,2 hexanediol 0.16, sodium polyglutamate 0.2, hyaluronic acid 0.05, sodium hyaluronate 0.02, water 75.
The preparation method of the malt extract comprises the following steps:
(1) selecting malt which germinates for 6 days as a raw material, and crushing;
(2) weighing 10g of crushed malt, adding 120ml of 25 wt% ethanol, stirring and mixing, performing ultrasonic treatment for 10 minutes, stirring and extracting at 75 ℃ for 3 hours, filtering and collecting filtrate; adding 0.03g of titanium dioxide powder into the obtained filtrate, irradiating for 15 seconds under a low-pressure mercury lamp, filtering, collecting the filtrate, concentrating, and drying to obtain powder A;
(3) adding 60ml of 70 wt% ethanol and 2g of auxiliary agent (glycerol) into the filter residue obtained by filtering in the step (2), performing microwave extraction for 45min under 480W power, filtering, collecting filtrate, concentrating, and drying to obtain powder B;
(4) mixing powder B and powder A in a ratio of 1: 2.8 by weight ratio to obtain the malt extract.
This example also provides a skin care product, which is a cosmetic product (same as example 3) purchased from any market and then used in combination with the three-dimensional moisturizing factor provided in this example. The specific application method is that 3 parts of commercially available cosmetics are mixed with 0.5 part of the three-dimensional moisturizing factor provided by the embodiment for use.
Comparative example 5
Comparative example 5 provides a three-dimensional moisturizing factor comprising, in parts by weight, saccharide isomer 30, ectoine 8, malt extract 2, caprylyl hydroximic acid 0.64, 1,2 hexanediol 0.16, sodium polyglutamate 0.2, hyaluronic acid 0.05, sodium hyaluronate 0.02, water 75.
The preparation method of the malt extract comprises the following steps:
(1) selecting malt which germinates for 2 days and 6 days as a raw material, and crushing;
(2) weighing 10g of crushed malt, adding 120ml of 25 wt% ethanol, stirring and mixing, performing ultrasonic treatment for 10 minutes, stirring and extracting at 75 ℃ for 3 hours, filtering and collecting filtrate; to the filtrate was added 0.03g of titanium dioxide powder, and after irradiating for 15 seconds under a low pressure mercury lamp, filtration was carried out, and the filtrate was collected, concentrated, and dried to obtain the malt extract.
The auxiliary agent is glycerol; the weight of the malt germinated for 2 days in the malt accounted for 38% of the total malt weight.
This example also provides a skin care product, which is a cosmetic product (same as example 3) purchased from any market and then used in combination with the three-dimensional moisturizing factor provided in this example. The specific application method is that 3 parts of commercially available cosmetics are mixed with 0.5 part of the three-dimensional moisturizing factor provided by the embodiment for use.
Comparative example 6
Comparative example 6 provides a three-dimensional moisturizing factor comprising, in parts by weight, saccharide isomer 30, ectoine 8, malt extract 2, caprylyl hydroximic acid 0.64, 1,2 hexanediol 0.16, sodium polyglutamate 0.2, hyaluronic acid 0.05, sodium hyaluronate 0.02, water 75.
The preparation method of the malt extract comprises the following steps:
(1) selecting malt which germinates for 2 days and 6 days as a raw material, and crushing;
(2) weighing 10g of crushed malt, adding 120ml of 25 wt% ethanol, stirring and mixing, performing ultrasonic treatment for 10 minutes, stirring and extracting at 75 ℃ for 3 hours, filtering and collecting filtrate; adding 0.03g of titanium dioxide powder into the obtained filtrate, irradiating for 15 seconds under a low-pressure mercury lamp, filtering, collecting the filtrate, concentrating, and drying to obtain powder A;
(3) adding 60ml of 70 wt% ethanol and 2g of auxiliary agent into the filter residue obtained by filtering in the step (2), performing microwave extraction for 45min under 480W power, filtering, collecting filtrate, concentrating, and drying to obtain powder B;
(4) mixing powder B and powder A in a ratio of 1: 0.5 by weight ratio to obtain the malt extract.
The auxiliary agent is glycerol; the weight of the malt germinated for 2 days in the malt accounted for 38% of the total malt weight.
This example also provides a skin care product, which is a cosmetic product (same as example 3) purchased from any market and then used in combination with the three-dimensional moisturizing factor provided in this example. The specific application method is that 3 parts of commercially available cosmetics are mixed with 0.5 part of the three-dimensional moisturizing factor provided by the embodiment for use.
Comparative example 7
Comparative example 7 provides a three-dimensional moisturizing factor comprising, in parts by weight, saccharide isomer 30, ectoine 8, malt extract 2, caprylyl hydroximic acid 0.64, 1,2 hexanediol 0.16, sodium polyglutamate 0.2, hyaluronic acid 0.05, sodium hyaluronate 0.02, water 75.
The preparation method of the malt extract comprises the following steps:
(1) selecting malt which germinates for 2 days and 6 days as a raw material, and crushing;
(2) weighing 10g of crushed malt, adding 120ml of 25 wt% ethanol, stirring, mixing, performing ultrasonic treatment for 10 minutes, stirring and extracting at 75 ℃ for 3 hours, filtering, collecting filtrate, concentrating, and drying to obtain powder A;
(3) adding 60ml of 70 wt% ethanol and 2g of auxiliary agent into the filter residue obtained by filtering in the step (2), performing microwave extraction for 45min under 480W power, filtering, collecting filtrate, concentrating, and drying to obtain powder B;
(4) mixing powder B and powder A in a ratio of 1: 2.8 by weight ratio to obtain the malt extract.
The auxiliary agent is glycerol; the weight of the malt germinated for 2 days in the malt accounted for 38% of the total malt weight.
This example also provides a skin care product, which is a cosmetic product (same as example 3) purchased from any market and then used in combination with the three-dimensional moisturizing factor provided in this example. The specific application method is that 3 parts of commercially available cosmetics are mixed with 0.5 part of the three-dimensional moisturizing factor provided by the embodiment for use.
Comparative example 8
Comparative example 8 provides a three-dimensional moisturizing factor comprising, in parts by weight, saccharide isomer 30, ectoine 8, malt extract 2, caprylyl hydroximic acid 0.64, 1,2 hexanediol 0.16, sodium polyglutamate 0.2, hyaluronic acid 0.05, sodium hyaluronate 0.02, water 75.
The preparation method of the malt extract comprises the following steps:
(1) selecting malt which germinates for 2 days and 6 days as a raw material, and crushing;
(2) weighing 10g of crushed malt, adding 120ml of 25 wt% ethanol, stirring and mixing, performing ultrasonic treatment for 10 minutes, stirring and extracting at 75 ℃ for 3 hours, filtering and collecting filtrate; adding 0.03g of titanium dioxide powder into the obtained filtrate, irradiating for 15 seconds under a low-pressure mercury lamp, filtering, collecting the filtrate, concentrating, and drying to obtain powder A;
(3) adding 60ml of 25 wt% ethanol and 2g of auxiliary agent into the filter residue obtained by filtering in the step (2), refluxing and extracting for 2 hours, filtering, collecting filtrate, concentrating and drying to obtain powder B;
(4) mixing powder B and powder A in a ratio of 1: 2.8 by weight ratio to obtain the malt extract.
The auxiliary agent is glycerol; the weight of the malt germinated for 2 days in the malt accounted for 38% of the total malt weight.
This example also provides a skin care product, which is a cosmetic product (same as example 3) purchased from any market and then used in combination with the three-dimensional moisturizing factor provided in this example. The specific application method is that 3 parts of commercially available cosmetics are mixed with 0.5 part of the three-dimensional moisturizing factor provided by the embodiment for use.
Comparative example 9
Comparative example 9 provides a three-dimensional moisturizing factor comprising, in parts by weight, saccharide isomer 30, ectoine 8, malt extract 2, caprylyl hydroximic acid 0.64, 1,2 hexanediol 0.16, sodium polyglutamate 0.2, hyaluronic acid 0.05, sodium hyaluronate 0.02, water 75.
The preparation method of the malt extract comprises the following steps:
(1) selecting malt which germinates for 2 days and 6 days as a raw material, and crushing;
(2) weighing 10g of crushed malt, adding 120ml of 25 wt% ethanol, stirring and mixing, performing ultrasonic treatment for 10 minutes, stirring and extracting at 75 ℃ for 3 hours, filtering and collecting filtrate; adding 0.03g of titanium dioxide powder into the obtained filtrate, irradiating for 15 seconds under a low-pressure mercury lamp, filtering, collecting the filtrate, concentrating, and drying to obtain powder A;
(3) adding 60ml of 70 wt% ethanol into the filter residue obtained by filtering in the step (2), performing microwave extraction for 45min under 480W power, filtering, collecting the filtrate, concentrating, and drying to obtain powder B;
(4) mixing powder B and powder A in a ratio of 1: 2.8 by weight ratio to obtain the malt extract.
The auxiliary agent is glycerol; the weight of the malt germinated for 2 days in the malt accounted for 38% of the total malt weight.
This example also provides a skin care product, which is a cosmetic product (same as example 3) purchased from any market and then used in combination with the three-dimensional moisturizing factor provided in this example. The specific application method is that 3 parts of commercially available cosmetics are mixed with 0.5 part of the three-dimensional moisturizing factor provided by the embodiment for use.
Comparative example 10
Comparative example 10 provides a skin care product, which is a cosmetic product (same as example 3) purchased at any place on the market.
Evaluation of Performance
1. Test for moisture retention
Due to the difference between the dielectric constants of water and other substances on the skin of a human body, the skin capacitance values of different moisture contents are different, so that the relative content of moisture in the skin can be known through a capacitance method. The specific test method comprises the following steps: the same amount of the three-dimensional moisturizing factor provided in the examples and comparative examples of the present application was applied to the same position and the same area on the inner side of the arm cleaned by each of the test persons within 48 hours during which the test persons did not use any other cosmetics. The moisture content of the stratum corneum of the test persons was then measured 2 hours and 48 hours after application of the moisturizing factor using a skin tester, model CK, germany, respectively. 10 volunteers of 22-40 years old are randomly selected from each sample, and the average value of the test results is taken. The moisture content test value is 0-150, and the higher the value is, the more the moisture content in the skin is.
Table 1 moisture retention test table
| 2 hour value | 48 hours value | |
| Example 1 | 113.2 | 57.7 |
| Example 2 | 115.8 | 62.5 |
| Example 3 | 124.1 | 81.9 |
| Example 4 | 122.6 | 77.2 |
| Comparative example 1 | 139.4 | 39.0 |
| Comparative example 2 | 80.0 | 26.4 |
| Comparative example 3 | 88.5 | 42.5 |
| Comparative example 4 | 119.3 | 51.3 |
| Comparative example 5 | 107.2 | 45.0 |
| Comparative example 6 | 83.1 | 40.7 |
| Comparative example 7 | 85.0 | 37.4 |
| Comparative example 8 | 106.6 | 41.6 |
| Comparative example 9 | 103.3 | 41.3 |
2. Stability test
(1) The three-dimensional moisturizing factor provided in the examples and comparative examples of the present application was tested for inhibition of staphylococcus aureus and escherichia coli. The specific operation method comprises the following steps: 1g of the three-dimensional moisturizing factor provided in the above examples and comparative examples was added to 20ml of a 50 wt% ethanol solution, and stirred to dissolve the three-dimensional moisturizing factor to obtain a three-dimensional moisturizing factor solution, which was stored for use.
Preparation of test bacterial suspensions: inoculating escherichia coli and staphylococcus aureus into a test tube culture medium, culturing for 48 hours at 37 ℃ in a thermostat, adding sterile distilled water, and shaking to obtain an experimental bacteria suspension. 15ml of the melted SOB medium was taken and placed in a sterile plate, and then 1ml of the test strain was added dropwise and allowed to spread flat on the bottom of the plate. After the culture medium is solidified, 4 Oxford cups are vertically placed on each flat plate, then 0.1ml of three-dimensional moisturizing factor solution is respectively added, and the size (unit: mm) of the diameter of the inhibition zone is respectively measured after the culture is carried out for 24 hours at 37 ℃.
(2) High-temperature stability: 5g of the skin care product (cream skin care product) provided by the above examples and comparative examples are put into a culture dish with the same size and specification, the culture dish is placed in a thermostat at 40 ℃ after being strickled off and is stored for a week, and then the culture dish is taken out to observe whether the skin care product has obvious deterioration conditions such as thinning, discoloration, layering, dehydration hardening, mildewing and the like.
Table 2 stability test results
3. Using skin feel testing
And randomly selecting 22-40 year-old test persons, and carrying out skin feeling test on the skin care products provided by the examples and the comparative examples. The specific method comprises the following steps: each sample was used by 50 people for 9 a/m: 30-10: 00 and 16 pm: 30-17: 00, continuously using for four weeks, not using any other cosmetics in the period, and recording the skin quality change of the tested person. After the skin care product provided by the application is used by a human subject, the skin of the human subject has no allergic characteristics such as irritation, pruritus, erythema and the like.
Table 3 results of skin feel test
| Obvious water-skiing of skin | Slightly improve the skin | The improvement is not obvious | |
| Example 1 | 45 | 5 | 0 |
| Example 2 | 46 | 4 | 0 |
| Example 3 | 49 | 1 | 0 |
| Example 4 | 49 | 1 | 0 |
| Comparative example 1 | 37 | 12 | 1 |
| Comparative example 2 | 33 | 15 | 2 |
| Comparative example 3 | 39 | 10 | 1 |
| Comparative example 4 | 40 | 10 | 0 |
| Comparative example 5 | 40 | 9 | 1 |
| Comparative example 6 | 39 | 10 | 1 |
| Comparative example 7 | 40 | 10 | 0 |
| Comparative example 8 | 38 | 10 | 2 |
| Comparative example 9 | 43 | 7 | 0 |
| Comparative example 10 | 27 | 15 | 8 |
Through the table, the three-dimensional moisturizing factor provided by the application has strong moisturizing property. The moisture-keeping factor has high water content when being applied and reaching the water absorption and water dispersion basically to balance (about 2 hours after being applied), and most of water can still be kept not to be lost after the moisture-keeping factor is applied for one time and waits for 48 hours. In addition the three-dimensional factor of moisturizing that this application provided has very strong moisturizing ability, still has certain antibacterial performance, does not need extra antiseptic also can preserve for a long time and do not deteriorate when using in the cosmetics. Moreover, the three-dimensional moisturizing factor provided by the application has good skin feeling experience, does not generate irritation or allergy to the skin, and enables the skin to be fresh and cool and to be elastic.
The foregoing examples are merely illustrative and serve to explain some of the features of the method of the present invention. The appended claims are intended to claim as broad a scope as is contemplated, and the examples presented herein are merely illustrative of selected implementations in accordance with all possible combinations of examples. Accordingly, it is applicants' intention that the appended claims are not to be limited by the choice of examples illustrating features of the invention. Also, where numerical ranges are used in the claims, subranges therein are included, and variations in these ranges are also to be construed as possible being covered by the appended claims.
Claims (4)
1. The three-dimensional moisturizing factor is characterized by comprising, by weight, 30 parts of saccharide isomers, 5-12 parts of ectoin, 1-5 parts of malt extract, 0.1-1.5 parts of caprylyl hydroximic acid, 0.1-0.4 part of 1, 2-hexanediol, 0.1-0.5 part of sodium polyglutamate, 0.01-0.2 part of hyaluronic acid, 0.01-0.1 part of sodium hyaluronate and 68-80 parts of water; the preparation method of the malt extract comprises the following steps: (1) selecting malt which germinates for 2 days and 6 days as a raw material, and crushing; (2) weighing 10g of crushed malt, adding 120ml of 25 wt% ethanol, stirring and mixing, performing ultrasonic treatment for 10 minutes, stirring and extracting at 75 ℃ for 3 hours, filtering and collecting filtrate; adding 0.03g of titanium dioxide powder into the obtained filtrate, irradiating for 15 seconds under a low-pressure mercury lamp, filtering, collecting the filtrate, concentrating, and drying to obtain powder A; (3) adding 60ml of 70 wt% ethanol and 2g of auxiliary agent into the filter residue obtained by filtering in the step (2), performing microwave extraction for 45min under 480W power, filtering, collecting filtrate, concentrating, and drying to obtain powder B; (4) mixing powder B and powder A in a ratio of 1: 2.8 to obtain the malt extract;
the weight of the malt which germinates for 2 days in the malt accounts for 30-40% of the total weight of the malt;
the auxiliary agent is glycerol and/or tetrahydropiperine.
2. The three-dimensional moisturizing factor according to claim 1, comprising, in parts by weight, saccharide isomer 30, ectoine 8, malt extract 2, caprylyl hydroximic acid 0.64, 1,2 hexanediol 0.16, sodium polyglutamate 0.2, hyaluronic acid 0.05, sodium hyaluronate 0.02, and water 75.
3. Use of the three-dimensional moisturizing factor according to claim 1 or 2 in the field of skin care products.
4. A skin care preparation comprising the three-dimensional moisturizing factor according to claim 1 or 2.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810181620.8A CN108261376B (en) | 2018-03-06 | 2018-03-06 | Three-dimensional moisturizing factor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810181620.8A CN108261376B (en) | 2018-03-06 | 2018-03-06 | Three-dimensional moisturizing factor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108261376A CN108261376A (en) | 2018-07-10 |
| CN108261376B true CN108261376B (en) | 2021-01-12 |
Family
ID=62774619
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810181620.8A Active CN108261376B (en) | 2018-03-06 | 2018-03-06 | Three-dimensional moisturizing factor |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108261376B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108685759B (en) * | 2018-07-11 | 2021-08-27 | 华熙生物科技股份有限公司 | Composition of hyaluronic acid substance and tetrahydropyrimidine substance |
| CN108785125B (en) * | 2018-08-23 | 2021-04-27 | 广东丸美生物技术股份有限公司 | Organic skin-care matrix with moisturizing and brightening effects, preparation method thereof, cosmetic composition and application |
| CN109846748A (en) * | 2018-11-02 | 2019-06-07 | 上海珈凯生物科技有限公司 | A kind of moisturiser containing black phycocolloid and preparation method thereof, application |
| CN109953902B (en) * | 2019-03-27 | 2022-02-22 | 山东智医智药生物科技有限公司 | A method for caring facial skin for non-therapeutic purpose |
| CN110812250B (en) * | 2019-11-12 | 2022-08-19 | 华熙生物科技股份有限公司 | Facial mask capable of rapidly gelling and preparation and application methods thereof |
| CN114469823B (en) * | 2021-06-24 | 2024-02-23 | 重庆米洛诊所管理有限公司 | Novel moisturizing factor composition and preparation and application thereof |
Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002089757A2 (en) * | 2001-05-09 | 2002-11-14 | Beiersdorf Ag | Use of isoflavones in cosmetic or dermatological preparations |
| JP2005336156A (en) * | 2003-10-14 | 2005-12-08 | Showa Denko Kk | Skin preparation for external use comprising salt of ascorbic acid derivative, stabilizing method of skin preparation for external use, and stabilizer |
| KR20070010359A (en) * | 2005-07-18 | 2007-01-24 | 주식회사 헬스 팜 | Composition for a pack sheet attached on skin |
| CN104473849A (en) * | 2014-12-05 | 2015-04-01 | 青岛海芬海洋生物科技有限公司 | Chinese herbal medicine skin-care beauty cream |
| EP2878340A1 (en) * | 2013-11-29 | 2015-06-03 | Latvijas Universitate | An abrasive ingredient for exfoliating cosmetic compositions |
| CN104840382A (en) * | 2014-02-18 | 2015-08-19 | 株式会社韩国化妆品制造 | Cosmetic composition containing chaga fermentation extract fermented in natural cavern condition |
| CN105411923A (en) * | 2015-12-03 | 2016-03-23 | 南京斯拜科生化实业有限公司 | Natural broad-spectrum anticorrosion composition containing grapefruit seed extract and application thereof |
| KR20160036834A (en) * | 2014-09-26 | 2016-04-05 | 한솔생명과학(주) | Skin external application composition comprising complex fermented extract of crude drug ingredients |
| CN105616320A (en) * | 2016-01-06 | 2016-06-01 | 衣明春 | Hand cream and preparation method thereof |
| CN105662955A (en) * | 2016-01-27 | 2016-06-15 | 安婕妤化妆品科技股份有限公司 | Cosmetic containing methyl-pyrimidine type substances |
| KR20160123956A (en) * | 2015-04-17 | 2016-10-26 | 주식회사 엘지생활건강 | Soluble micro-needle patch for skin volume augmentation |
| CN107714559A (en) * | 2017-11-27 | 2018-02-23 | 曾万祥 | One kind is without anti-corrosion deep water supplement skin care item |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4342560A1 (en) * | 1993-12-14 | 1995-06-22 | Marbert Gmbh | Use of 1,4,5,6-tetra:hydro-4-pyrimidine carboxylic acid derivs. in cosmetics |
| KR20060121848A (en) * | 2003-08-28 | 2006-11-29 | 쇼와 덴코 가부시키가이샤 | Cosmetic composition comprising a and a lipopeptide |
-
2018
- 2018-03-06 CN CN201810181620.8A patent/CN108261376B/en active Active
Patent Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002089757A2 (en) * | 2001-05-09 | 2002-11-14 | Beiersdorf Ag | Use of isoflavones in cosmetic or dermatological preparations |
| JP2005336156A (en) * | 2003-10-14 | 2005-12-08 | Showa Denko Kk | Skin preparation for external use comprising salt of ascorbic acid derivative, stabilizing method of skin preparation for external use, and stabilizer |
| KR20070010359A (en) * | 2005-07-18 | 2007-01-24 | 주식회사 헬스 팜 | Composition for a pack sheet attached on skin |
| EP2878340A1 (en) * | 2013-11-29 | 2015-06-03 | Latvijas Universitate | An abrasive ingredient for exfoliating cosmetic compositions |
| CN104840382A (en) * | 2014-02-18 | 2015-08-19 | 株式会社韩国化妆品制造 | Cosmetic composition containing chaga fermentation extract fermented in natural cavern condition |
| KR20160036834A (en) * | 2014-09-26 | 2016-04-05 | 한솔생명과학(주) | Skin external application composition comprising complex fermented extract of crude drug ingredients |
| CN104473849A (en) * | 2014-12-05 | 2015-04-01 | 青岛海芬海洋生物科技有限公司 | Chinese herbal medicine skin-care beauty cream |
| KR20160123956A (en) * | 2015-04-17 | 2016-10-26 | 주식회사 엘지생활건강 | Soluble micro-needle patch for skin volume augmentation |
| CN105411923A (en) * | 2015-12-03 | 2016-03-23 | 南京斯拜科生化实业有限公司 | Natural broad-spectrum anticorrosion composition containing grapefruit seed extract and application thereof |
| CN105616320A (en) * | 2016-01-06 | 2016-06-01 | 衣明春 | Hand cream and preparation method thereof |
| CN105662955A (en) * | 2016-01-27 | 2016-06-15 | 安婕妤化妆品科技股份有限公司 | Cosmetic containing methyl-pyrimidine type substances |
| CN107714559A (en) * | 2017-11-27 | 2018-02-23 | 曾万祥 | One kind is without anti-corrosion deep water supplement skin care item |
Non-Patent Citations (4)
| Title |
|---|
| "Production of hybrid strains among Pleutorus and Lentinula and evaluation of their mycelial growth kinetics on malt extract agar and wheat grain using the Gompertz and Hill models";Juan Diego Valenzuela Cobos等;《Emirates Journal of Food and Agriculture》;20171231;第29卷(第12期);第927-935页 * |
| "大麦在发芽过程中营养物质的变化及其营养评价";张端莉等;《食品科学》;20141231;第35卷(第1期);第229-233页 * |
| "大麦籽粒中γ－氨基丁酸、总黄酮和生物碱";曾亚文等;《麦类作物学报》;20121231;第32卷(第1期);第135-139页 * |
| "青藏高原盐湖嗜盐微生物资源及应用";孔凡晶，王现洁;《科技导报》;20170628;第35卷(第12期);第27-31页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN108261376A (en) | 2018-07-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108261376B (en) | Three-dimensional moisturizing factor | |
| CN108685759B (en) | Composition of hyaluronic acid substance and tetrahydropyrimidine substance | |
| CN104736136B (en) | Beauty and make-up is used or medicinal moisturizing ingredient | |
| WO2021003962A1 (en) | Skincare composition for repairing skin, and preparation method therefor | |
| KR102263479B1 (en) | Cosmetic composition for anti-aging comprising heat-killed Lactobacillus plantarum or culture of the Lactobacillus plantarum | |
| FR2770776A1 (en) | USES OF D-XYLOSE AND ITS ESTERS TO IMPROVE THE FUNCTIONALITY OF SKIN CELLS | |
| CN110051587A (en) | A kind of preparation method and application of the anti-apolexis composition containing a variety of sodium hyaluronates | |
| CN105796474B (en) | A kind of solid multifunctional mask composition and the method for preparing facial mask | |
| CN110585076A (en) | Prebiotics and probiotic composition, and preparation method and application thereof | |
| CN110623882A (en) | Whitening and freckle removing mask and preparation method thereof | |
| CN103705428B (en) | For the nonionic composition and method of making the same of cutin of dispelling | |
| CN108836919B (en) | Moisturizing cosmetic composition and preparation method and application thereof | |
| CN110115704B (en) | Enzyme composition and application thereof in cosmetics with whitening function | |
| CN110664644B (en) | Skin care composition containing folic acid, essence and preparation method thereof | |
| US20220105020A1 (en) | Hyaluronic acid skin care composition and preparation method and application thereof | |
| CN110522713B (en) | Milk-based liposome eye cream capable of resisting wrinkles, removing fat particles and blacking eyes and preparation method thereof | |
| KR20050103903A (en) | Topical composition and methods for treatment of aged or environmentally damaged skin | |
| KR20210141142A (en) | Cosmetic compositions for skin care and hair care and preparation methods thereof | |
| CN112773761A (en) | Cosmetic composition, essence and preparation method thereof | |
| CN111973511A (en) | Moisturizing composition and skin care product | |
| KR20030034520A (en) | Cosmetic compositions containing levan | |
| CN116440048A (en) | Composite retinol composition and preparation method and application thereof | |
| CN109771326A (en) | A kind of composition for whitening Face-protecting mask | |
| KR20150116504A (en) | A cosmetics composition containing tea tree and solt | |
| CN108852977B (en) | Crystal moistening essence |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20181227 Address after: 214400 Room 301, Building 48, Sanyuanfang Lane, Jiangyin City, Wuxi City, Jiangsu Province Applicant after: Chen Xiao Address before: Room 804, Building No. 51, Zhengxue Road, Yangpu District, Shanghai 200082 Applicant before: SENZHI (SHANGHAI) INTERNATIONAL TRADE CO.,LTD. |
|
| CB02 | Change of applicant information | ||
| CB02 | Change of applicant information |
Address after: No.369, Qianchao Road, Jianggan District, Hangzhou City, Zhejiang Province Applicant after: Chen Xiao Address before: 214400 Room 301, Building 48, Sanyuanfang Lane, Jiangyin City, Wuxi City, Jiangsu Province Applicant before: Chen Xiao |
|
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20201211 Address after: Room 0443, 2 / F, jilou, 555 Dongchuan Road, Minhang District, Shanghai, 201100 Applicant after: SHANGHAI KEYAN BIOTECHNOLOGY Co.,Ltd. Address before: No.369, Qianchao Road, Jianggan District, Hangzhou City, Zhejiang Province Applicant before: Chen Xiao |
|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20240507 Address after: 200240, Room 4320, Building C, No. 555 Dongchuan Road, Minhang District, Shanghai Patentee after: Shanghai Guangdi Law Biotechnology Co.,Ltd. Country or region after: China Address before: Room 0443, 2 / F, jilou, 555 Dongchuan Road, Minhang District, Shanghai, 201100 Patentee before: SHANGHAI KEYAN BIOTECHNOLOGY Co.,Ltd. Country or region before: China |