CN108175527B - 具备可见光机能化功能的种植体基台穿龈结构及制作方法 - Google Patents
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Abstract
本发明公开了一种具备可见光机能化功能的种植体基台穿龈结构及制作方法,其结构包括有种植体基台,种植体基台的材质为钛,种植体基台是由基台上部、基台穿龈结构和基台下部,基台穿龈结构位于基台上部和基台下部之间,台穿龈结构表面为具有载纳米金粒子的TiO2纳米管的纳米结构,该结构具有在可见光照射下产生光机能化的特性。将基台穿龈结构通过阳极氧化法及自组装方法,制备了负载纳米金粒子TiO2纳米管结构。本发明的基台穿龈结构,在可见光照射下产生光机能化作用,产生的超氧自由基、羟基自由基能杀灭种植体周围炎致病菌,破坏菌斑生物膜,净化种植体基台穿龈结构表面,用以预防和治疗种植体周围炎。
Description
技术领域
本发明涉及医学植入技术领域,具体涉及一种口腔种植体基台穿龈结构及其制备方法。
背景技术
口腔种植系统通常包括三个部分:植入牙槽骨中的体部、人工牙冠以及在体部与人工牙冠之间起连接作用的种植体基台。
种植体周围炎的病因包括基因多态性、微生物感染、吸烟、种植体表面粗糙和基台选择不当等。种植体基台穿龈结构是种植体周围炎发生和发展的重要部位,种植体义齿周的菌斑微生物积累可能发展成为种植体周围炎,导致种植体周的炎症或感染,并伴随支持骨的丧失,最终种植失败。目前临床上常用的治疗种植体周围炎的方法主要有手术治疗、超声洁治加局部用药单独或联合治疗及光动力疗法等。手术治疗、超声洁治等常规方法为有创或微创治疗过程,而且对种植体周围炎的预防没有任何作用。
光动力疗法是最新应用于种植体周围炎的方法,光动力疗法应用需要光敏剂和激光。光敏剂是一种本身能选择性集中于靶细胞的化学物质,在适当波长光的激发下能产生光动力效应而破坏靶细胞。
在一些体外实验中,Hass解释了种植体周围炎光动力杀菌效果,如Aa、Pg、Pi可粘附到不同特性的钛板表面,在钛板上孵化细菌,电子显微镜扫描分析显示光动力疗法在杀灭细菌的同时不会破坏种植体表面结构。Shibli证明光动力抗菌治疗能够减少种植体表面中间普氏菌、产黑色杆菌、梭形杆菌、β-溶血性链球菌等的细菌数量。
根据已有的研究,光动力疗法由于其在抗菌方面的确切作用及其与抗生素不同的杀菌机制,将会是种植体周围炎较有潜力的一种辅助治疗方法。它能克服机械治疗和药物治疗的缺点,缩短治疗时间,减少患者治疗的痛苦,减轻对周围组织的损伤。
目前临床光动力治疗还有一些不足,首先需要患者购买昂贵的光敏剂,需要特殊设备才能完成治疗,从而大幅增加患者的治疗支出;其次光敏剂只选择性的结合一类细菌,并单一对细菌破坏,对于种植体周围炎的炎性因子的影响并未见报道,抗炎范围单一而且局限。因此,对于种植体基台穿龈结构的优化具有重要意义。
发明内容
本发明的目的在于克服现有技术存在的不足,提供了一种具备可见光机能化功能的种植体基台穿龈结构及制作方法,从而使该基台穿龈结构能够在可见光照射下产生光机能化作用,无差别化杀灭致病菌,分解致炎因子,净化基台穿龈结构表面,为炎症的恢复和上皮再附着提供生物学基础,用以预防和治疗种植体周围炎。
本发明之具备可见光机能化功能的种植体基台穿龈结构,其包括有种植体基台,种植体基台的材质为钛,种植体基台是由基台上部、基台穿龈结构和基台下部,基台穿龈结构位于基台上部和基台下部之间,台穿龈结构表面为具有载纳米金粒子的TiO2纳米管的纳米结构。
本发明之具备可见光机能化功能的种植体基台穿龈结构的制作方法包括以下步骤:
1)、种植体基台经过水砂纸依次打磨至表面光滑,无明显缺陷;
2)、然后,经过打磨的种植体基台依次在丙酮、乙醇和蒸馏水中各超声清洗5-6min;室温干燥;
3)、电极的设置:阳极为种植体基台,阴极为铂环;
4)、阳极氧化:用体积百分百浓度为75%甘油溶液,0.01-1mol/L氟化铵体系为电解液,设置阳极电压为10V-60V、在种植体基台的基台穿龈结构表面制备自组装TiO2纳米管;氧化时间设置为1-10h;氧化完成后的种植体基台在乙醇溶液中超声清洗,并在空气中自然风干;
5)、热处理:将步骤4)氧化并风干后的种植体基台在空气中用箱式炉煅烧400℃,每分钟降低5℃,3小时逐渐冷却至室温;
6)、先将固态氯金酸溶于异丙醇中配制成0.01-0.5mol/L的氯金酸溶液;把基台穿龈结构2表面负载有TiO2纳米管的种植体基台竖直插进装有氯金酸溶液的小烧杯中,并用保鲜膜密封;放置30min后直接用紫外光照射,紫外光由300W高压汞灯提供,紫外光的波长λ为350~420nm,高压汞灯与基台穿龈结构2表面负载有TiO2纳米管的种植体基台相距约20cm,紫外光照射时间为10-180min;照射完成后,将照射后的种植体基台用去离子水反复冲洗,然后在加热板上80℃烘干4h;
7)、将步骤6)处理后的种植体基台依次在丙酮、乙醇、蒸馏水中清洗各5-6min;室温干燥;制作的种植体基台的基台穿龈结构2表面为负载纳米金粒子的TiO2纳米管结构,具有在430-485nm波长可见光区产生光机能化作用的特性。
附图说明
图1是本发明的具备可见光机能化功能的种植体基台穿龈结构主视图。
图2是本发明的具备可见光机能化功能的种植体基台穿龈结构图像。
具体实施方式
如图1所示,本发明之具备可见光机能化功能的种植体基台穿龈结构,其包括有种植体基台,种植体基台的材质为钛,种植体基台是由基台上部1、基台穿龈结构2和基台下部3,基台穿龈结构2位于基台上部1和基台下部3之间,基台穿龈结构2表面具有负载纳米金粒子的TiO2纳米管的纳米结构。负载纳米金粒子的TiO2纳米管的纳米结构如图2所示。
本发明之具备可见光机能化功能的种植体基台穿龈结构的制作方法包括以下步骤:
1)、种植体基台经过水砂纸依次打磨至表面光滑,无明显缺陷;
2)、然后,经过打磨的种植体基台依次在丙酮、乙醇和蒸馏水中各超声清洗5-6min;室温干燥;
3)、电极的设置:阳极为种植体基台,阴极为铂环;
4)、阳极氧化:用体积百分百浓度为75%甘油溶液,0.01-1mol/L氟化铵体系为电解液,设置阳极电压为10V-60V、在种植体基台的基台穿龈结构2表面制备自组装TiO2纳米管;氧化时间设置为1-10h;氧化完成后的种植体基台在乙醇溶液中超声清洗,并在空气中自然风干;
5)、热处理:将步骤4)氧化并风干后的种植体基台在空气中用箱式炉煅烧400℃,每分钟降低5℃,3小时逐渐冷却至室温;
6)、先将固态氯金酸溶于异丙醇中配制成0.01-0.5mol/L的氯金酸溶液;把基台穿龈结构2表面负载有TiO2纳米管的种植体基台竖直插进装有氯金酸溶液的小烧杯中,并用保鲜膜密封;放置30min后直接用紫外光照射,紫外光由300W高压汞灯提供,紫外光的波长λ为350~420nm,高压汞灯与基台穿龈结构2表面负载有TiO2纳米管的种植体基台相距约20cm,紫外光照射时间为10-180min;照射完成后,将照射后的种植体基台用去离子水反复冲洗,然后在加热板上80℃烘干4h;
7)、将步骤6)处理后的种植体基台依次在丙酮、乙醇、蒸馏水中各清洗5-6min;室温干燥;制作的种植体基台的基台穿龈结构2表面为负载纳米金粒子的TiO2纳米管结构,具有在430-485nm波长可见光区产生光机能化作用的特性。
所述的种植体基台的材质为钛。
实施例1:种植体基台的材质为钛。
1)、种植体基台经过1000#-5000#水砂纸依次打磨至表面光滑,无明显缺陷;
2)、然后,经过打磨的种植体基台依次在丙酮、乙醇和蒸馏水中各超声清洗5-6min;室温干燥;
3)、电极的设置:阳极为种植体基台,阴极为铂环;
4)、阳极氧化:体积百分百浓度为75%甘油溶液,0.27mol/L氟化铵体系为电解液,阳极电压为10V、30V或60V,在种植体基台的基台穿龈结构2表面制备自组装TiO2纳米管;氧化时间设置为3h,氧化完成之后种植体基台在乙醇溶液中超声清洗,并在空气中自然风干;
5)热处理:将步骤4)氧化并风干后的种植体基台在空气中用箱式炉煅烧400℃,每分钟降低5℃,3小时逐渐冷却至室温;
6)、先将固态氯金酸溶于异丙醇中配制成0.01mol/L的氯金酸溶液;把基台穿龈结构2表面负载有TiO2纳米管的种植体基台竖直插进装有氯金酸溶液的小烧杯中,并用保鲜膜密封;放置30min后直接用紫外光照射,紫外光由300W高压汞灯提供,紫外光的波长λ为350~420nm,高压汞灯与基台穿龈结构2表面负载有TiO2纳米管的种植体基台相距约20cm,紫外光照射时间为20min;照射完成后,将照射后的种植体基台用去离子水反复冲洗,然后在加热板上80℃烘干4h;
7)、将步骤6)处理后的种植体基台依次在丙酮、乙醇、蒸馏水中各清洗5-6min;室温干燥。
实施例2:种植体基台的材质为钛。
1)、种植体基台经过1000#-5000#水砂纸依次打磨至表面光滑,无明显缺陷;
2)、然后,经过打磨的种植体基台依次在丙酮、乙醇和蒸馏水中各超声清洗5-6min;室温干燥;
3)、电极的设置:阳极为种植体基台,阴极为铂环;
4)、阳极氧化:体积百分百浓度为75%甘油溶液,0.27mol/L氟化铵体系为电解液,阳极电压为30V,在种植体基台的基台穿龈结构2表面制备自组装TiO2纳米管;氧化时间设置为1h、5h和10h,氧化完成之后种植体基台在乙醇溶液中超声清洗,并在空气中自然风干;
5)热处理:将步骤4)氧化并风干后的种植体基台在空气中用箱式炉煅烧400℃,每分钟降低5℃,3小时逐渐冷却至室温;
6)、先将固态氯金酸溶于异丙醇中配制成0.01mol/L的氯金酸溶液;把基台穿龈结构2表面负载有TiO2纳米管的种植体基台竖直插进装有氯金酸溶液的小烧杯中,并用保鲜膜密封;放置30min后直接用紫外光照射,紫外光由300W高压汞灯提供,紫外光的波长λ为350~420nm,高压汞灯与基台穿龈结构2表面负载有TiO2纳米管的种植体基台相距约20cm,紫外光照射时间为20min;照射完成后,将照射后的种植体基台用去离子水反复冲洗,然后在加热板上80℃烘干4h;
7)、将步骤6)处理后的种植体基台依次在丙酮、乙醇、蒸馏水中各清洗5-6min;室温干燥。
实施例3:种植体基台的材质为钛。
1)、种植体基台经过1000#-5000#水砂纸依次打磨至表面光滑,无明显缺陷;
2)、然后,经过打磨的种植体基台依次在丙酮、乙醇和蒸馏水中各超声清洗5-6min;室温干燥;
3)、电极的设置:阳极为种植体基台,阴极为铂环;
4)、阳极氧化:体积百分百浓度为75%甘油溶液,0.27mol/L氟化铵体系为电解液,阳极电压为30V,在种植体基台的基台穿龈结构2表面制备自组装TiO2纳米管;氧化时间设置为1h、5h和10h,氧化完成之后种植体基台在乙醇溶液中超声清洗,并在空气中自然风干;
5)热处理:将步骤4)氧化并风干后的种植体基台在空气中用箱式炉煅烧400℃,每分钟降低5℃,3小时逐渐冷却至室温;
6)、先将固态氯金酸溶于异丙醇中配制成0.01mol/L的氯金酸溶液;把基台穿龈结构2表面负载有TiO2纳米管的种植体基台竖直插进装有氯金酸溶液的小烧杯中,并用保鲜膜密封;放置30min后直接用紫外光照射,紫外光由300W高压汞灯提供,紫外光的波长λ为350~420nm,高压汞灯与基台穿龈结构2表面负载有TiO2纳米管的种植体基台相距约20cm,紫外光照射时间
10min、30min、60min和180min;照射完成后,将照射后的种植体基台用去离子水反复冲洗,然后在加热板上80℃烘干4h;
7)、将步骤6)处理后的种植体基台依次在丙酮、乙醇、蒸馏水中各清洗5-6min;室温干燥。
Claims (1)
1.一种具备可见光机能化功能的种植体基台穿龈结构的制备方法,其种植体基台穿龈结构包括有种植体基台,种植体基台的材质为钛;种植体基台是由基台上部(1)、基台穿龈结构(2)和基台下部(3)构成,基台穿龈结构(2)位于基台上部(1)和基台下部(3)之间,基台穿龈结构(2)表面具有负载纳米金粒子的TiO2纳米管的纳米结构;
其特征在于:包括以下步骤:
1)、种植体基台经过水砂纸依次打磨至表面光滑,无明显缺陷;
2)、然后,经过打磨的种植体基台依次在丙酮、乙醇和蒸馏水中各超声清洗5-6min;室温干燥;
3)、电极的设置:阳极为种植体基台,阴极为铂环;
4)、阳极氧化:用体积百分百浓度为75%甘油溶液,0.01-1mol/L氟化铵体系为电解液,设置阳极电压为10V-60V,在种植体基台的基台穿龈结构(2)表面制备自组装TiO2纳米管;氧化时间设置为1-10h;氧化完成后的种植体基台在乙醇溶液中超声清洗,并在空气中自然风干;
5)、热处理:将步骤4)氧化并风干后的种植体基台在空气中用箱式炉煅烧400℃,每分钟降低5℃,3小时逐渐冷却至室温;
6)、先将固态氯金酸溶于异丙醇中配制成0.01-0.5mol/L的氯金酸溶液;把基台穿龈结构( 2) 表面负载有TiO2纳米管的种植体基台竖直插进装有氯金酸溶液的小烧杯中,并用保鲜膜密封;放置30min后直接用紫外光照射,紫外光由300W高压汞灯提供,紫外光的波长λ为350~420nm,高压汞灯与基台穿龈结构(2)表面负载有TiO2纳米管的种植体基台相距约20cm,紫外光照射时间为10-180min;照射完成后,将照射后的种植体基台用去离子水反复冲洗,然后在加热板上80℃烘干4h;
7)、将步骤6)处理后的种植体基台依次在丙酮、乙醇、蒸馏水中各清洗5-6min;室温干燥;制作的种植体基台的基台穿龈结构(2)表面具有负载纳米金粒子的TiO2纳米管结构,具有在430-485nm波长可见光区产生光机能化作用的特性。
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