CN108126128A - A kind of oral antimicrobial gelling agent and preparation method thereof - Google Patents
A kind of oral antimicrobial gelling agent and preparation method thereof Download PDFInfo
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- CN108126128A CN108126128A CN201810104893.2A CN201810104893A CN108126128A CN 108126128 A CN108126128 A CN 108126128A CN 201810104893 A CN201810104893 A CN 201810104893A CN 108126128 A CN108126128 A CN 108126128A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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Abstract
The invention discloses a kind of oral antimicrobial gelling agent and preparation method thereof, including following component：Deionized water,Peroxidating is urinated,Cool feeling agent,Oat anti-sensitizer,Poloxamer188,PLURONICS F87,Each ingredient is by weight percentage,Wherein deionized water accounts for 54.95%,Peroxidating urine accounts for 23%,Cool feeling agent accounts for 0.05%,Oat anti-sensitizer accounts for 1%,Poloxamer188 accounts for 20%,PLURONICS F87 accounts for 1%,In its preparation process the function of disinfection can be played by adding in peroxidating urine,By adding in poloxamer188 and PLURONICS F87,Solution is enable to carry out gelation,Using and being administered convenient for people,By adding in cool feeling agent,Can allow user use it is a during removal halitosis and ensure lasting nice and cool in oral cavity,By adding oat anti-sensitizer,The antianaphylactic effect in oral cavity can be played,The present invention, which has, goes halitosis,Canker sore,Swelling and aching of gum,Implication clearly function and effect,Its acting surface light,Function is more,It is highly practical,With good using effect.
Description
Technical field
The present invention relates to field of oral care, and in particular to a kind of oral antimicrobial gelling agent and preparation method thereof.
Background technology
With the continuous improvement of living standards of the people quality, people’s lives rhythm is getting faster, and then work dinner party or kith and kin
Good friend's party has become extremely usual thing, drifts apart again after dinner party or party and is busy with the cause of oneself, few people's note
Weight oral hygiene keeps the cleaning in oral cavity.If things go on like this, food residual contained in oral cavity easily grows deformation hammer in oral cavity
The growth of bacterium, food residual are easily sent out liquor-saturated into harmful dental plaque acid, eventually cause saprodontia.
In recent years, the incidence of saprodontia is higher and higher, has been assessed as threatening the three of human health by the World Health Organization
Big chronic disease killer, the in addition to this also appearance of the illnesss such as periodontosis and plaque, periodontosis are that adult's tooth is caused to lose
One of the main reason for mistake and the main oral disease for endangering human teeth and whole body health.Juvenile periodontitis is to involve
Chronic degenerative's damage of the periodontium of most teeth, its main feature is that most patients are younger, pathological development is rapid, so that hair
Sick early stage tooth occurs as soon as loosening, displacement, periodontal bag formation, secondary infection then occurs, inflammation is caused to change.Pathogenic factors can
Can periodontosis related with heredity refer to be happened at tooth supporting tissue（Periodontium）Disease, the tooth including only involving gingiva tissue
Gingival disease and involve deep layer periodontium（Parodontium, alveolar bone, cementum）Two major class of periodontitis.Plaque bacteria and its product
It is the most important cause of disease of periodontosis, is to cause the indispensable initiation factor of periodontosis.Mainly poor oral hygiene, microorganism
Effect, particularly calculus dentalis stimulation, tooth subgingival calculus harmfulness are maximum.Systemic factor and Nutrition and Metabolism obstacle, endocrine disturbance,
Vegetative nerve functional disturbance etc. is related.In addition, the stimulation of wound, ill fitting prosthesis is also one of cause of disease.Total is divided into part
With whole body both sides factor.Local factor has considerable effect, and systemic factor can influence periodontium to local thorn
Sharp reaction, there is substantial connection between the two.
Periodontal disease therapeutic can be divided into operative treatment, Chinese traditional treatment and dietotherapy, and the process for the treatment of is different, and according to
Different patient doctors can design different therapeutic schemes.So everyone there will be good oral hygiene, prevent oral cavity disease
Disease..
There are many oral health care product currently on the market, such as using xylitol and peppermint as the chewing gum of primary raw material, with
Pseudo-ginseng, chrysanthemum etc. are the toothpaste of primary raw material, although these chewing gums or toothpaste can reduce the germ in oral cavity, reduce tooth
Incidence, but without anti-inflammatory and analgesic effect.
It is known for many years comprising display bacterial plaque dyestuff oral care composition and it include liquid, tablet, purificant,
Spray, pastille and dentifrice material.However, it has proved that the application of these compositions is dirty and messy, because dyestuff may not
Can only bacterial plaque be coloured, and lip, gums, tongue, mouth area, towel and work top coloring can be made.
The fungicide used in presently commercially available dental health product is mainly quaternary ammonium salt, cetylpyridinium chloride and chloro
The cationic active agents such as own pyridine (chlorohexidene), wherein especially most with chlorohexidene application, but they all there is coloring, interference tastes
The defects of feeling, inhibiting foam, itself bitter and promote the formation of calculus, and oral problem is varied, existing oral cavity medicine
Product can only be treated targetedly, and effect is more single, functional not powerful enough, need further to be improved.
Invention content
The present invention provides a kind of oral antimicrobial gelling agent and preparation method thereof, and it is varied to solve oral problem, existing
Oral pharmaceutical product can only targetedly be treated, effect is more single, it is functional not powerful enough the problem of.
In order to solve the above technical problem, the present invention provides following technical solutions：
A kind of oral antimicrobial gelling agent of the present invention and preparation method thereof, including following component：Deionized water, peroxidating urine, cool feeling
Agent, oat anti-sensitizer, poloxamer188, PLURONICS F87, each ingredient is by weight percentage：Wherein deionized water accounts for
54.95%th, peroxidating urine, which accounts for 23%, cool feeling agent and accounts for 0.05%, oat anti-sensitizer and account for 1%, poloxamer188, accounts for 20%, poloxamer
188 account for 1%.
As a preferred technical solution of the present invention, in preparation process, the pH value of solution is controlled between 6.5-7.
A kind of oral antimicrobial gelling agent and preparation method thereof, includes the following steps：
Step 1：Pure water progress deionization is handled to obtain deionized water；
Step 2：Oat anti-sensitizer, poloxamer188 and PLURONICS F87 are added in into deionized water and is mixed；
Step 3：Peroxidating is urinated in the solution added in step 2 and is stirred for five minutes；
Step 4：It is stirred ten minutes after cool feeling agent is added in the solution in step 3 simultaneously；
Step 5：Product obtained is fitted into bottle and is sealed preservation；
As a preferred technical solution of the present invention, colourless liquid cool feeling agent is selected in the cool feeling agent, can give oral tape
Carry out long-acting refrigerant sense.
As a preferred technical solution of the present invention, above-mentioned steps two, Step 3: whipping process in step 4 with
Motor driving agitating paddle is at the uniform velocity stirred, and avoids occurring foam in whipping process, so as to influence the state of finished product, and step
2nd, Step 3: the stirring work in step 4 carries out under vacuum conditions, solution is avoided by extraneous dust and air
Impurity pollution.
As a preferred technical solution of the present invention, the poloxamer188, PLURONICS F87 select white powder
Last shape solid particle, and poloxamer188, PLURONICS F87 are mixed in the environment of temperature is less than 20 degree, are kept away
The phenomenon that exempting to flocculate in whipping process makes stirring more abundant.
Compared with prior art, the advantageous effect that is reached of the present invention is：A kind of oral antimicrobial that the present invention is stated coagulates
Jelly and preparation method thereof can play the function of disinfection in preparation process by adding in peroxidating urine, pass through addition and moor Lip river
Husky nurse 407 and PLURONICS F87, enable solution to carry out gelation, using and being administered convenient for people, by adding in cool feeling
Agent, can allow user use it is a during removal halitosis and ensure lasting nice and cool in oral cavity, by adding oat antiallergic
Agent, can play the antianaphylactic effect in oral cavity, and the present invention has the function of halitosis and canker sore, swelling and aching of gum, implication clearly
And effect, acting surface light, function is more, highly practical, has good using effect.
Specific embodiment
Technical solution in the embodiment of the present invention is clearly and completely described, it is clear that described embodiment is only
It is part of the embodiment of the present invention, instead of all the embodiments, based on the embodiments of the present invention, ordinary skill people
Member's all other embodiments obtained without making creative work, shall fall within the protection scope of the present invention.
The present invention provides a kind of technical solution：A kind of oral antimicrobial gelling agent and preparation method thereof, including following component：It goes
Ionized water, peroxidating urine, cool feeling agent, oat anti-sensitizer, poloxamer188, PLURONICS F87, each ingredient is with weight percent
Meter：Wherein deionized water, which accounts for 54.95%, peroxidating urine and accounts for 23%, cool feeling agent and account for 0.05%, oat anti-sensitizer, accounts for 1%, poloxamer
407, which account for 20%, PLURONICS F87, accounts for 1%.
Further, in preparation process, the pH value of solution is controlled between 6.5-7.
A kind of oral antimicrobial gelling agent and preparation method thereof, includes the following steps：
Step 1：Pure water progress deionization is handled to obtain deionized water；
Step 2：Oat anti-sensitizer, poloxamer188 and PLURONICS F87 are added in into deionized water and is mixed；
Step 3：Peroxidating is urinated in the solution added in step 2 and is stirred for five minutes；
Step 4：It is stirred ten minutes after cool feeling agent is added in the solution in step 3 simultaneously；
Step 5：Product obtained is fitted into bottle and is sealed preservation；
Further, colourless liquid cool feeling agent is selected in cool feeling agent, and long-acting refrigerant sense can be carried out to oral tape.
Further, above-mentioned steps two, Step 3: whipping process in step 4 carried out with motor driving agitating paddle it is even
Speed stirring, avoids occurring foam in whipping process, so as to influence the state of finished product, and Step 2: Step 3: in step 4
Stirring work carries out under vacuum conditions, and solution is avoided to be polluted by the impurity in extraneous dust and air.
Further, the poloxamer188, PLURONICS F87 select white powdery solids particle, and it is husky to moor Lip river
Nurse 407, PLURONICS F87 are mixed in the environment of temperature is less than 20 degree, avoid wadding a quilt with cotton in whipping process
The phenomenon that solidifying, make stirring more abundant.
Concrete principle：Deionized water is made by deionization mode in common pure water, is then come with deionized water molten
Solve peroxidating urine, cool feeling agent, oat anti-sensitizer, poloxamer188 and PLURONICS F87, lysate between PH6.5-7 into
Row, peroxidating urine and cool feeling agent add in two times, and at the uniform velocity stir five minutes and 15 minutes respectively after the addition, can
Reach sufficient dissolving, and ingredient is evenly distributed among solution.
A kind of oral antimicrobial gelling agent that the present invention is stated and preparation method thereof, by adding in peroxide in preparation process
The function of disinfection can be played by changing urine, by adding in poloxamer188 and PLURONICS F87, solution be enable to carry out gelation,
Using and being administered convenient for people by adding in cool feeling agent, can allow user using a removal halitosis and guarantor in the process
Card oral cavity is lasting to feel nice and cool, and by adding oat anti-sensitizer, can play the antianaphylactic effect in oral cavity, the present invention, which has, removes mouth
Smelly, canker sore, swelling and aching of gum, implication clearly function and effect, acting surface light, function is more, highly practical, has fine
Using effect.
Finally it should be noted that：The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention,
Although the present invention is described in detail referring to the foregoing embodiments, for those skilled in the art, still may be used
To modify to the technical solution recorded in foregoing embodiments or carry out equivalent replacement to which part technical characteristic.
All within the spirits and principles of the present invention, any modification, equivalent replacement, improvement and so on should be included in the present invention's
Within protection domain.
Claims (6)
1. a kind of oral antimicrobial gelling agent and preparation method thereof, which is characterized in that including following component：Deionized water, peroxidating
Urine, cool feeling agent, oat anti-sensitizer, poloxamer188, PLURONICS F87, each ingredient is by weight percentage：Wherein deionization
Water account for 54.95%, peroxidating urine account for 23%, cool feeling agent account for 0.05%, oat anti-sensitizer account for 1%, poloxamer188 account for 20%,
PLURONICS F87 accounts for 1%.
2. a kind of oral antimicrobial gelling agent according to claim 1 and preparation method thereof, which is characterized in that in preparation process
In, the pH value of solution is controlled between 6.5-7.
3. a kind of oral antimicrobial gelling agent according to claim 1 and preparation method thereof, which is characterized in that including following step
Suddenly：
Step 1：Pure water progress deionization is handled to obtain deionized water；
Step 2：Oat anti-sensitizer, poloxamer188 and PLURONICS F87 are added in into deionized water and is mixed；
Step 3：Peroxidating is urinated in the solution added in step 2 and is stirred for five minutes；
Step 4：It is stirred ten minutes after cool feeling agent is added in the solution in step 3 simultaneously；
Step 5：Product obtained is fitted into bottle and is sealed preservation.
A kind of 4. oral antimicrobial gelling agent according to claim 1 and preparation method thereof, which is characterized in that the cool feeling agent
Colourless liquid cool feeling agent is selected, long-acting refrigerant sense can be carried out to oral tape.
A kind of 5. oral antimicrobial gelling agent according to claim 1 and preparation method thereof, which is characterized in that above-mentioned steps
2nd, it Step 3: the whipping process in step 4 is at the uniform velocity stirred with motor driving agitating paddle, avoids going out in whipping process
Existing foam, so as to influence the state of finished product, and Step 2: Step 3: stirring work in step 4 under vacuum conditions into
Row avoids solution from being polluted by the impurity in extraneous dust and air.
6. a kind of oral antimicrobial gelling agent according to claim 1 and preparation method thereof, which is characterized in that the pool Lip river is husky
Nurse 407, PLURONICS F87 select white powdery solids particle, and poloxamer188, PLURONICS F87 are low in temperature
The phenomenon that being mixed in the environment of 20 degree, avoid flocculating in whipping process makes stirring more abundant.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201810104893.2A CN108126128A (en) | 2018-02-02 | 2018-02-02 | A kind of oral antimicrobial gelling agent and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810104893.2A CN108126128A (en) | 2018-02-02 | 2018-02-02 | A kind of oral antimicrobial gelling agent and preparation method thereof |
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| CN108126128A true CN108126128A (en) | 2018-06-08 |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1925835A (en) * | 2004-03-03 | 2007-03-07 | 沃纳-兰伯特有限公司 | Stabilized peroxide compositions |
| CN102639100A (en) * | 2009-08-20 | 2012-08-15 | 托马斯·贝尔纳多·加尔万冈萨雷斯 | Antibacterial pharmaceutical composition for oral hygiene and treatment of oral diseases of microbial origin |
| CN104922139A (en) * | 2015-05-20 | 2015-09-23 | 南京泽恒医药技术开发有限公司 | In-situ gel spray for treating oral cavity fungal infection |
| CN106466482A (en) * | 2015-08-20 | 2017-03-01 | 康多宝医疗健康产品（湖南）有限公司 | A kind of compositionss of prevention, treatment or suppression membrane disease and preparation method thereof |
| CN106620612A (en) * | 2016-12-24 | 2017-05-10 | 李大兴 | Traditional Chinese medicine gargle |
| CN106821950A (en) * | 2017-01-23 | 2017-06-13 | 衡阳美娇七商贸有限公司 | The oral care composition and its application of a kind of antibacterial and whitening |
-
2018
- 2018-02-02 CN CN201810104893.2A patent/CN108126128A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1925835A (en) * | 2004-03-03 | 2007-03-07 | 沃纳-兰伯特有限公司 | Stabilized peroxide compositions |
| CN102639100A (en) * | 2009-08-20 | 2012-08-15 | 托马斯·贝尔纳多·加尔万冈萨雷斯 | Antibacterial pharmaceutical composition for oral hygiene and treatment of oral diseases of microbial origin |
| CN104922139A (en) * | 2015-05-20 | 2015-09-23 | 南京泽恒医药技术开发有限公司 | In-situ gel spray for treating oral cavity fungal infection |
| CN106466482A (en) * | 2015-08-20 | 2017-03-01 | 康多宝医疗健康产品（湖南）有限公司 | A kind of compositionss of prevention, treatment or suppression membrane disease and preparation method thereof |
| CN106620612A (en) * | 2016-12-24 | 2017-05-10 | 李大兴 | Traditional Chinese medicine gargle |
| CN106821950A (en) * | 2017-01-23 | 2017-06-13 | 衡阳美娇七商贸有限公司 | The oral care composition and its application of a kind of antibacterial and whitening |
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| Title |
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| 方亮: "《药用高分子材料学》", 31 August 2015, 中国医药科技出版社 * |
| 窦宏仪等: "高粘度、多功能过氧化脲洁牙凝胶的制备研究 ", 《化学推进剂与高分子材料》 * |
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