CN1081031C - 一种钙片 - Google Patents
一种钙片 Download PDFInfo
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- CN1081031C CN1081031C CN98100629A CN98100629A CN1081031C CN 1081031 C CN1081031 C CN 1081031C CN 98100629 A CN98100629 A CN 98100629A CN 98100629 A CN98100629 A CN 98100629A CN 1081031 C CN1081031 C CN 1081031C
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- CN
- China
- Prior art keywords
- calcium
- glycine
- tablet
- eaten
- calcium tablet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title claims abstract description 28
- 239000011575 calcium Substances 0.000 title claims abstract description 28
- 229910052791 calcium Inorganic materials 0.000 title claims abstract description 28
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000004471 Glycine Substances 0.000 claims abstract description 12
- 239000004615 ingredient Substances 0.000 claims abstract description 7
- 229920002472 Starch Polymers 0.000 claims abstract description 6
- 235000019698 starch Nutrition 0.000 claims abstract description 6
- 239000008107 starch Substances 0.000 claims abstract description 6
- 238000007796 conventional method Methods 0.000 claims abstract description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
- 239000000463 material Substances 0.000 claims description 7
- 239000000796 flavoring agent Substances 0.000 claims description 4
- 235000013355 food flavoring agent Nutrition 0.000 claims description 4
- 239000002994 raw material Substances 0.000 claims description 2
- 238000001035 drying Methods 0.000 claims 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract description 6
- 238000010521 absorption reaction Methods 0.000 abstract description 2
- 239000003814 drug Substances 0.000 abstract description 2
- 230000003203 everyday effect Effects 0.000 abstract description 2
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 229940046008 vitamin d Drugs 0.000 abstract description 2
- OFNJDDJDXNMTHZ-UHFFFAOYSA-L calcium;2-aminoacetate Chemical compound [Ca+2].NCC([O-])=O.NCC([O-])=O OFNJDDJDXNMTHZ-UHFFFAOYSA-L 0.000 abstract 1
- 235000013409 condiments Nutrition 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 238000007873 sieving Methods 0.000 abstract 1
- 229960005069 calcium Drugs 0.000 description 18
- 239000013522 chelant Substances 0.000 description 6
- 239000013589 supplement Substances 0.000 description 6
- 206010006956 Calcium deficiency Diseases 0.000 description 3
- 150000001413 amino acids Chemical group 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 2
- 235000001014 amino acid Nutrition 0.000 description 2
- 125000000129 anionic group Chemical group 0.000 description 2
- 229910001424 calcium ion Inorganic materials 0.000 description 2
- 210000000170 cell membrane Anatomy 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 229910021645 metal ion Inorganic materials 0.000 description 2
- 241000251468 Actinopterygii Species 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 108010016626 Dipeptides Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- 229930003316 Vitamin D Natural products 0.000 description 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 235000001465 calcium Nutrition 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 229960003563 calcium carbonate Drugs 0.000 description 1
- 235000010216 calcium carbonate Nutrition 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 description 1
- 229960002401 calcium lactate Drugs 0.000 description 1
- 239000001527 calcium lactate Substances 0.000 description 1
- 235000011086 calcium lactate Nutrition 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 208000007442 rickets Diseases 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
Landscapes
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
本发明涉及一种钙片，属保健药。它主要以甘氨酸钙为主料，甘氨酸、医用淀粉、糖粉等为副料，加调味剂，经研磨、混配、过筛、制粒、烘干等常规方法制作而成，它制造容易，食用简单，食用时不用加维生素D，不用吃鱼甘油，吸收率高，用量少，每天最多不超过50mg，可补充人体对钙的生理要求。
Description
本发明涉及一种钙片，具体的说是涉及一种可补充人体对钙的生理要求，并易于吸收的补钙剂，属保健药。
目前，关于补钙的营养强化剂、添加剂，碳酸钙、乳酸钙、磷酸氢钙等，因其分子量大或需配合维生素D服用，被生物体吸收效果差，其主要原因是因为这些化合物都是难溶性的盐类物质，其阴离子的存在妨碍了钙的被吸收。在小肠壁，钙离子要首先同多肽、二肽或某种氨基酸形成螯合物，然后整体通过细胞膜进入细胞体，最后螯合链断开，钙离子被各种酶结合，形成含钙氨基酸而被生物体吸收。
欧洲专利Eu Patent 240288公开了制备该种螯合物的技术，认为只有无阴离子的螯合物才能通过细胞膜而被细胞所吸收利用。我国一些研究者也曾作过这方面的理论研究，认为各种金属离子只有同氨基酸形成中性螯合物，才能把金属离子搬运到生物细胞中去。而且，这种螯合物的分子量越小越好，因该螯合物是作为一个整体通过生物细胞的。
缺钙对人体所产生的影响，在医学界早已有定论，人体缺钙会引发多种疾病，儿童会引起佝偻病，绝经妇女和老年人，容易引起骨质疏松，而发生骨折，最新的研究又指出缺钙会使心脏病、高血压发病率升高，会引起多种心脑血管病，人们对补钙的重要性又有了新的认识，但是目前国内外的补钙剂都不符合真实的吸收过程，却不少补钙剂都有不同成度的副作用，而如何实现有效的补钙，以保障身体健康是一个多年来尚未根本解决的问题。
本发明的目的在于提供一种以甘氨酸钙为主料，可补充人体对钙的生理要求，并易于吸收的补钙剂。
本发明的目的是这样实现的，它主要以甘氨酸钙为主料，甘氨酸、医用淀粉、糖粉为副料，加调味剂，经研磨、混配、过筛、制料、烘干常规方法制作而成，其特征在于：它是由下述重量配比的原料制成
主料
甘氨酸钙 0.8-1.2g
副料
甘氨酸 0.25-0.4g 医用淀粉 1.6-2.4g
糖 粉 0.016-0.024g 食用酒精 0.4-0.6g
调味剂
食用香精 0.0016-0.0024g
其特征还在于：所述的食用酒精的浓度为85％。
本发明的一种钙片，它制造容易，食用简单，食用时不用加维生素-D，不用吃鱼甘油，吸收率高，用量少，每天最多不超过50mg，可补充人体对钙的生理要求。
下面结合实施例说明本发明
实施例：
一、按下述重量配比的原料称重
①取100g甘氨酸钙，并研磨成50目的细粉，
②商购
甘氨酸 30g 医用淀粉 200g
糖粉 2g 浓度为85％食用酒精 50g
食用香精 0.2g
二、经混配、过筛、制粒、烘干、轧制成型常规方法制作成片重为300mg本发明的一种钙片。
本发明的“一种钙片”，又称“南新钙片”或称“全新生理钙”。它在本质上不同于目前的任何一种补钙剂，它容易被人体吸收，是一种新型的补钙剂。
Claims (2)
1.一种钙片，它主要以甘氨酸钙为主料，甘氨酸、医用淀粉、糖粉为副料，加调味剂，经研磨、混配、过筛、制料、烘干常规方法制作而成，其特征在于：它是由下述重量配比的原料制成
主料
甘氨酸钙 0.8-1.2g
副料
甘氨酸 0.25-0.4g 医用淀粉 1.6-2.4g
糖 粉 0.016-0.024g 食用酒精 0.4-0.6g
调味剂
食用香精 0.0016-0.0024g
2.根据权利要求1所述的一种钙片，其特征还在于：所述的食用酒精的浓度为85％。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98100629A CN1081031C (zh) | 1998-02-23 | 1998-02-23 | 一种钙片 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98100629A CN1081031C (zh) | 1998-02-23 | 1998-02-23 | 一种钙片 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1187991A CN1187991A (zh) | 1998-07-22 |
| CN1081031C true CN1081031C (zh) | 2002-03-20 |
Family
ID=5216140
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN98100629A Expired - Fee Related CN1081031C (zh) | 1998-02-23 | 1998-02-23 | 一种钙片 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1081031C (zh) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102935086A (zh) * | 2012-12-10 | 2013-02-20 | 刘胜伟 | 一种钙片 |
| CN103919136B (zh) * | 2014-04-29 | 2016-07-06 | 吉林大学 | 一种蛋氨酸鳌合钙片及加工方法 |
| CN103922949A (zh) * | 2014-04-29 | 2014-07-16 | 吉林大学 | 一种亮氨酸鳌合钙粉及加工方法 |
-
1998
- 1998-02-23 CN CN98100629A patent/CN1081031C/zh not_active Expired - Fee Related
Non-Patent Citations (1)
| Title |
|---|
| 中国药房1996年第7卷5期 1996.1.1 梅丹.李大魁和庞国辉 补钙剂的应用和选择 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1187991A (zh) | 1998-07-22 |
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| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: TIANJIN NANDA XINGYUN BIOMEDICAL DEVELOPMENT CO., Free format text: FORMER OWNER: ZHANG JINGKUN Effective date: 20031224 |
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| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20031224 Address after: 300241 No. 6, Zhongshan North Road, Tianjin, Hebei District, No. 1 Patentee after: Nanda Xingyun Biological Medicine Development Co., Ltd., Tianjin Address before: 300071 Southwest Village, Nankai University, Tianjin, 62-2-405 Patentee before: Zhang Jingkun |
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| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |