CN108096289A - A kind of antrodia capsule formula and production method - Google Patents
A kind of antrodia capsule formula and production method Download PDFInfo
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- CN108096289A CN108096289A CN201711460670.1A CN201711460670A CN108096289A CN 108096289 A CN108096289 A CN 108096289A CN 201711460670 A CN201711460670 A CN 201711460670A CN 108096289 A CN108096289 A CN 108096289A
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Abstract
The present invention relates to pharmaceutical technology fields, and in particular to a kind of antrodia capsule formula, including it is following by weight：10 parts~500 parts of Antrodia camphorata powder.It is eaten by the way that Antrodia camphorata powder is fabricated to capsule, there is the effect of removing toxic substances liver protection, tonifying kidneys, strengthening heart, the whole intestines of beneficial stomach, enhancing are immunized, for adjusting the illnesss such as immunity of organism, treatment liver cancer, stomach cancer.
Description
Technical field
The present invention relates to pharmaceutical technology field, specifically more particularly to a kind of antrodia capsule formula and production method.
Background technology
Antrodia camphorata is mainly grown on Taiwan, and Antrodia camphorata possesses medical value in itself, and people are eaten by culinary art and controlled to reach
Disease is treated, is taken good care of one's health, still, the Antrodia camphorata medical value after culinary art is had a greatly reduced quality, moreover edible not convenient enough.
The content of the invention
In consideration of it, the present invention is directed to propose a kind of antrodia capsule formula and production method, strong with removing toxic substances liver protection, kidney tonifying
The effect of heart, the whole intestines of beneficial stomach, enhancing are immunized, for adjusting the illnesss such as immunity of organism, treatment liver cancer, stomach cancer.
To achieve these goals, first aspect present invention embodiment provides a kind of antrodia capsule formula, including following
By weight：10 parts~500 parts of Antrodia camphorata powder.
Optionally, in above-mentioned antrodia capsule formula, including it is following by weight：The Antrodia camphorata powder 50 parts~450
Part.
Optionally, in above-mentioned antrodia capsule formula, including it is following by weight：The Antrodia camphorata powder 100 parts~400
Part.
Optionally, in above-mentioned antrodia capsule formula, including it is following by weight：The Antrodia camphorata powder 150 parts~350
Part.
Optionally, in above-mentioned antrodia capsule formula, including it is following by weight：The Antrodia camphorata powder 200 parts~300
Part.
Optionally, in above-mentioned antrodia capsule formula, including it is following by weight：250 parts of the Antrodia camphorata powder.
The antrodia capsule that the embodiment of first party of the present invention provides is matched somebody with somebody, and is eaten by the way that Antrodia camphorata powder is fabricated to capsule, is had
Have detoxifying liver protection, tonifying kidneys, strengthening heart, the whole intestines of beneficial stomach, the effect of enhancing is immune, for adjusting immunity of organism, treatment liver cancer, stomach cancer etc.
Illness.
Second aspect of the present invention embodiment provides a kind of method for making antrodia capsule, comprises the following steps：
The antrodia capsule formula that any one of such as above-mentioned first aspect side embodiment is provided, the Antrodia camphorata are ground into carefully
Powder, and 120 mesh sieves are crossed, reuse filling machine filling capsule.
The capsule made by this method, it is easy to process quick, without excessive manpower and materials.
Specific embodiment
To make the purpose, technical scheme and advantage of the embodiment of the present invention clearer, below in the embodiment of the present invention
Technical solution is clearly and completely described, it is clear that described embodiment be the present invention part of the embodiment rather than
Whole embodiments.Based on the embodiments of the present invention, those of ordinary skill in the art are not before creative work is made
All other embodiments obtained are put, belong to the scope of protection of the invention.
The present invention is described in further detail below：
First aspect present invention embodiment provides a kind of antrodia capsule formula, including following Antrodia camphorata by weight
Powder, the Antrodia camphorata powder are 10 parts~500 parts,
In this embodiment, optionally, Antrodia camphorata powder is 50 parts~450 parts, and Antrodia camphorata powder is 100 parts~400 parts, Cinnamomum kanahirai hay
Sesame powder is 150 parts~350 parts, and Antrodia camphorata powder is 200 parts~300 parts, and Antrodia camphorata powder is 250 parts.
It is eaten by the way that Antrodia camphorata powder is fabricated to capsule, there is removing toxic substances liver protection, tonifying kidneys, strengthening heart, the whole intestines of beneficial stomach, enhancing to be immunized
The effect of, for adjusting the illnesss such as immunity of organism, treatment liver cancer, stomach cancer.
Antrodia capsule is to be refined from Antrodia camphorata through the techniques such as water alcohol extracting, concentration, has protecting liver, lowering enzymes, anti-liver is swollen
Knurl inhibits the generation of liver ascites, enhancing immunization etc..Add the nomenclature principle of dosage form according to medicine name, determine the entitled " camphor tree of this product
Sesame capsule ", and corresponding Chinese phonetic alphabet title is corresponding with, it is mainly used for the auxiliary treatment of clinical liver cancer.
Second aspect of the present invention embodiment provides a kind of method for making antrodia capsule, comprises the following steps：
The antrodia capsule formula that any one of such as above-mentioned first aspect side embodiment is provided, Antrodia camphorata are ground into fine powder, and
120 mesh sieves are crossed, reuse filling machine filling capsule.
The capsule made by this method, it is easy to process quick, without excessive manpower and materials.
Third aspect present invention embodiment provides another antrodia capsule formula, including including following ox by weight
10 parts~500 parts of antrodia powder, 10 parts~20 parts of the fruit of Chinese wolfberry, 2 parts~5 parts of Radix Astragali, 6 parts~8 parts of radix bupleuri, 2 parts~5 parts of oriental wormwood, plate
Blue 5 parts~10 parts of root, 2 parts~5 parts of Schisandra chinensis, 2 parts~5 parts of Pulvis Fellis Suis, 10 parts~15 parts of mung bean.For dispersing stagnated hepatoqi, invigorating the spleen
It helps digestion, plays an important role of to reduce transaminase, it is hard for fatty liver, alcoholic liver, drug induced hepatic injury, chronic hepatitis and early stage liver
Change, have and relieve the effect of alcohol, is lipid-loweringing, removing toxic substances, anti-inflammatory and other effects.
Product are hard shell capsules, and content is brown to chocolate brown powder, gas raw meat, bitter.
Differentiate：Antrodia camphorata powder 2g is taken, adds ethyl alcohol 30ml, is heated to reflux 30 minutes, is filtered, filtrate is evaporated, and residue adds methanol
2ml Antrodia camphoratas powder dissolves, as test solution.Adenosine reference substance separately is taken, adds methanol that every mixing of the l ml containing 2mg is made molten
Liquid, as reference substance solution.According to thin-layered chromatography《Chinese Pharmacopoeia》The 4th general rule 0502 of version in 2015) experiment, it draws above-mentioned
Each 4 μ l of two kinds of solution, put respectively in same carboxymethylcellulose sodium solution for binder silica GF254 lamellae on, with three
Chloromethanes-ethyl acetate-isopropanol-water-strong ammonia solution (8:2:6:0.3:0.2) it is solvent, is unfolded, takes out, dry, put purple
It is inspected under outer smooth lamp (254nm).In test sample chromatography, on position corresponding with reference substance chromatography, the spot of same color is shown.
It checks：Every regulation related under capsule item should be met《Chinese Pharmacopoeia》The 4th general rule 0103 of version in 2015).
Assay polysaccharide：According to UV-VIS spectrophotometry (《Chinese Pharmacopoeia》The 4th general rule 0401 of version in 2015)
It measures.
The preparation of reference substance solution takes DEXTROSE ANHYDROUS reference substance appropriate, accurately weighed, adds water that every 1ml is made containing 0.1mg
Solution to get.
The preparation of standard curve respectively it is accurate measure reference substance solution 0.1ml, 0.2ml, 0.4ml, 0.6ml, 0.8ml,
1.0ml, 1.2ml, 1.4ml are put in 10ml tool plug test tubes, add water to 2.0ml, precision adds in sulfuric acid anthrone solution, and (precision weighs
Anthrone 0.1g, adds 80% sulfuric acid solution 100ml to make dissolving, shakes up) 6ml, it shakes up, puts in water-bath and heat 15 minutes, take out, put
Enter in ice-water bath and cool down 15 minutes, using corresponding reagent as blank, according to UV-VIS spectrophotometry (general rule 0401),
Absorbance is measured at 625nm wavelength, using absorbance as ordinate, concentration is abscissa, draws standard curve.
The preparation of test solution takes this product content mixing under content uniformity item, takes about 1g, accurately weighed, puts
In 100ml conical flasks, every time plus water 20ml, water-bath flow back 2 times, every time 2 it is small when, centrifugation merges supernatant and is simultaneously transferred to 50ml
In volumetric flask, scale is diluted with water to, is shaken up；Precision measures 10ml, adds absolute ethyl alcohol 90ml, shakes up, when 4 DEG C of placements 12 are small,
It takes out, centrifugation, incline supernatant, and precipitation is dissolved in water, and is transferred in 50ml measuring bottles, adds water to scale, shakes up；It is accurate again to measure
1ml until in 10ml volumetric flasks, is diluted with water to scale, shake up to get.
Measuring method：Precision measures test solution 1ml, puts in 10ml tool plug test tubes, under the preparation of sighting target directrix curve
Method from " precision add in sulfuric acid anthrone solution 6ml ", measures absorbance in accordance with the law, calculate to get.
This product every should must not be less than 50.0mg containing polysaccharide in terms of D- DEXTROSE ANHYDROUSs (C6H12O6).Total triterpene according to it is ultraviolet-
Visible spectrophotometry (《Chinese Pharmacopoeia》The 4th general rule 0401 of version in 2015) it measures.
The preparation of reference substance solution takes oleanolic acid reference substance appropriate, accurately weighed, adds methanol that every 1ml is made containing 0.2mg
Solution to get.
The preparation of standard curve：Respectively it is accurate measure reference substance solution 0.1ml, 0.2ml, 0.3ml, 0.4ml, 0.6ml,
Most solvent is waved in 0.8ml, 1.0ml, 60 DEG C of water-baths, adds 5% vanillic aldehyde-glacial acetic acid solution of 0.3ml brand-news and the examination of 1ml perchloric acid
Agent is heated 20 minutes in 60 DEG C of waters bath with thermostatic control, and ice-water bath cools down 10 minutes, adds 10ml glacial acetic acid, shakes up, using corresponding reagent as
Blank according to UV-VIS spectrophotometry (general rule 0401), measures absorbance at 548nm wavelength, is sat using absorbance to be vertical
Mark, concentration is abscissa, draws standard curve.
The preparation of test solution：This product content mixing under content uniformity item is taken, takes about 0.5g, it is accurately weighed, it puts
In 100ml conical flask with cover, precision adds in 90% methanol 20ml, and close plug shakes up, weighed weight, be ultrasonically treated (power 300W,
Frequency 45kHz) 1 it is small when, take out, let cool, then weighed weight, the weight of less loss is supplied with 90% methanol, shake up to get.
Measuring method：Precision draws 100 μ l of test solution, puts in 10ml tool plug test tubes, and most solvent is waved in water-bath, and sighting target is accurate bent
Method under the preparation of line from " the 5% vanillic aldehyde-glacial acetic acid solution for adding in 0.3ml brand-news ", measures absorbance in accordance with the law,
Calculate to get.This product every should must not be less than 10.0mg containing total triterpene in terms of oleanolic acid (C30H48O3).Function is with curing mainly：
The effect of being immunized with removing toxic substances liver protection, tonifying kidneys, strengthening heart, the whole intestines of beneficial stomach, enhancing.For adjusting immunity of organism, treatment liver cancer, stomach cancer
Etc. illnesss.Usage and dosage：It is oral.One time 2-4,2-3 times on the one.Specification：Every dress 0.45g.Storage：It is closed, shady place
It preserves.
Antrodia camphorata (Antrodia cinnamomea), belongs to Aphyllophorales, Polyporaceae, antrodia karst, antrodia kind, is
Perennial gill fungus mushroom, also known as cinnamomum kanahirai hay mushroom.Antrodia camphorata fragrant odour, acrid flavour, hardship.The rotten wood for being grown on Taiwan and continent (south) is true
Bacterium, two it is century-old before be just related to its record, medical value is high, and effect is more, and attending scope is wide, with strong liver, clearing heat and detoxicating,
Anti-liver cancer and anti-and other effects is considered as most precious medicinal material by among the people since ancient times, be forest in ruby, national treasure grade mushroom class, once
King for ganoderma lucidum is praised, as the hot spot of modern scientific research.
1. Antrodia camphorata starts from nineteen ninety as medicinal into scientific name research, by related scholar couple over more than 20 years
It is widely studied, and has delivered more than 200 piece research papers (1), is once caused including Chinese (continent and Taiwan), Japan, the U.S.
Deng the highest attention of related academia, what is valued is that Antrodia camphorata can be in following hepatopathy, cancer and the prevention and health care for solving the mankind
Contribution.
Plant result of study shows that Antrodia camphorata contains anti-hepatitis B and the triterpene effective constituents of hepatitis C virus are up to 10-
45%；The polysaccharide component for improving immunocompetence is up to 13.13%, is similar mushroom " most " (2) at present.Pharmacological research shows
Antrodia camphorata extract inhibits hepatitis virus, the generation for inhibiting liver fibrosis, protecting liver, lowering enzymes, anti-liver cancer and anti-and its ascites；Enhancing is exempted from
Epidemic disease function, improves allergic constitution, and treatment allergic asthma has obvious curative effects；Also there is heat-clearing, removing toxic substances, antiinflammation.In addition ox
The reconciliation fatigue effect of relieving the effect of alcohol of antrodia is also the big feature of one.
In view of Antrodia camphorata more than various features, the active drug of current clinical treatment hepatitis B, hepatitis and liver cancer is less in addition,
Therefore this research plans Antrodia camphorata extract and is developed into military medical organization preparation, is dedicated to army or even the whole society, be hepatopathy and
Liver cancer patient is benefited, and makes it to obtain the Social benefit and economic benefit of more preferable bigger.
2. composition, we are Antrodia camphorata simple, and capsule preparations are made in its medicinal extract.
3. prescription source, we are Empirical formula, by famous old docter of TCM doctor Wang Dejun, the clinical practice Cinnamomum kanahirai hay in more than 20 years of product
The prescription of the summary of experience of sesame treatment hepatopathy out.And many data studied with reference to Taiwan with the continent modern times Antrodia camphorata,
Plan its research and development into the non-standard preparation of army (capsule preparations) with Modern preparations characteristic, in a manner of fast and easily in army
Or even the whole nation expands application range, serves more hepatopaths.
4. theoretical foundation
4.1 Antrodia camphoratas contain abundant chemical composition
It is found from substantial amounts of research report in recent years, Antrodia camphorata contains there are many complicated ingredient, such as different essential oils, polysaccharide body
(Polysaccharides) (its main chemical compositions is β-D-glucan (callose)), triterpene compound (such as camphor tree mushroom
Sour A, B, C, K etc.), Sudismase (SOD), that nucleic acid includes adenosine (Adenosine), core candy nucleotide (RNA), gland is fast
It is the substances such as purine (Adenine), uracil (Uracil), ergosterol, protein (contain immune protein), vitamin, amino acid, solidifying
Poly- element and some trace elements etc..
It is most special with triterpene compound in these active ingredients, the up to 200 kinds or more (ganoderma lucidum of single strain about 20-
50 kinds, different lines ganoderma lucidum is always and about more than 200 kind), content is 10%-45% (ganoderma lucidum 1%-3%), is that other mushrooms can not
It compares；Polysaccharide body content is 13.13% (ganoderma lucidum 2%).
It is analyzed according to related data, in the obtained class Triterpenoid of antrodia fructification, is respectively provided with 24 (28)-en on branch
Framework shows that the class triterpene metabolic pathway of antrodia is very different with ganoderma lucidum, and this branch framework should can be used as the spy of antrodia
Levy ingredient.Since 2008, have three patents on Antrodia camphorata active ingredient and be applied success in the U.S., be respectively：
4.1.1 cyclohexenone compound and application in Antrodia camphorata：This patent is that one kind extraction from Antrodia camphorata separates, is pure
The new compound of change：(4-hydroxy-2,3-dimethoxy-6-methyl-5(3,7,11-
trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone).The compound before this from
It is not found, research finds that it has stronger activity in the growth for inhibiting cancer cell, such as liver cancer, breast cancer and prostate
Cancer；The duplication of its DNA of its anticancer mechanism with inhibition and the transcription of RNA are related.
4.1.2 in Antrodia camphorata fructification drug ingredient presence：This patent is a kind of separated from Antrodia camphorata fructification
Novel Diterpenes chemical combination, the diterpene compound have obtained verification experimental verification as neuroprotective agent.
4.1.3 in Antrodia camphorata compound inhibit cancer growth of tumour cell：This patent is the extraction point from Antrodia camphorata
Separating out the another kind come has the new compound of active anticancer：(4,7-dimethoxy-5-methy-1,3-
Benzodioxole), the growth to inhibiting liver cancer cells is obvious.
4.2 Antrodia camphorata has stronger pharmacological activity
4.2.1 anti-kinds cancer is confirmed according to biomedicine institute of Changgeng Univ. of Taiwan Linkou County result of study, Antrodia camphorata extract
There is apparent inhibitory action to the growth of the cancer cells such as liver cancer, the cancer of the brain, lung cancer, leukemia, breast cancer, cervix cancer.Chen Yuren is cured
Teacher and doctor Zhang Dongzhu and straight benevolence researcher time-consuming 6 years, train formula Antrodia camphorata fructification as material using ware, extract with separating
It obtains a kind of molecular formula and is the dehydrosulphurenic acid compound of C31H48O4, and use it for the treatment white blood of acute myeloid
Sick cancer cell tests and achieves significant curative effect.
The antitumor heat subject having become as people's research of Antrodia camphorata, research find that Antrodia camphorata passes through following approach in recent years
Antitumaous effect is played, 1. to DNA, the influence of RNA, by inhibiting or destroying their synthesis, tumour cell to be prevented to breed；②
Inducing cell apoptosis by inhibiting cell Proliferation, induces tumor cell differentiation or apoptosis；3. to the adjustment effect of immune function,
Body immune system can limit growth of cancer cells, adjusted by biological respinse and change biological respinse of the host to cancer；4. to tumour
The influence of cell Proliferation；5. tumor cell differentiation is induced, by drug-induced tumour cell to normal cell turnover, while to just
Normal cell is without lethal effect, and the side effects such as rare bone marrow suppression；6. influence to tumor cell gene expression etc..
Week et al. extracts polysaccharide body with Antrodia camphorata mycelium, and research has shown that, molecular weight>The adjustable ganglion cells of AC-PS of 100kD swash
Element secretion acts on to inhibit HUVECS angiogenesis, has the ability for inhibiting cancer metastasis.Pharmacological research shows that antrodia is real
Isolated Zhankuic acidA and Zhankuic acid C have cell toxicant for the lymphocytic cancer cell P388 of mouse in body
Property, IC50 is respectively 1.8 and 5.4 μ g/mL, and Liu et al. people has obtained a polysaccharide component (AC-PS) from Antrodia camphorata mycelium,
Can the multiplication of human leukemia cell U937 be inhibited by activated mononuclear cell (MNCs).Experiment in vivo shows oral or abdomen
Chamber injection AC-PS can inhibit the multiplication of 180 cells of mouse Sarcoma, and inhibiting rate is respectively 58.8% and 69.1%.Root
According to the experiment as a result, Liu thinks that AC-PS is to play antitumor action by adjusting immune system rather than directly kill
Hinder the experiment of tumour cell point, it was demonstrated that antrodia can effectively inhibit the growth of cancer cell.
4.2.2 anti-HBV effect antrodia fructification contains abundant triterpene compound, and antrodia polysaccharide has anti-second
Hepatopathy cytotoxic activity is to report for the first time in mycota.The antrodia extract of five different strains all has the activity of anti-hepatitis virus.
In 50 μ g/mL, the polysaccharide component in bacterial strain B86 plays an important role of best anti-hepatitis B virus surface antigen, and effect is better than
The effect of alpha-interferon during 1000U/mL.There was only the work that B86 and CCRC35398 has anti-hepatitis virus e antigens in five bacterial strains
Property.Each polysaccharide component does not show cytotoxicity.Huang et al. has found that antrodia ethanol extract is thin for hepatitis B wild strain
Born of the same parents and lamivudine tolerance type cell are respectively provided with growth inhibition effect.By the screening of effect on hepatitics B virus in vitro pharmacological evaluation,
Huang isolated 2,2 ', 5,5 '-tetramethoxy-3,4,3 ' of active ingredient from antrodia ethanol extract,
4’-bimethylenedioxy-6,6’-dimethyl-biphenyl。
4.2.3 protecting liver, lowering enzymes Antrodia camphorata with obvious effects be earliest be used for treating by Original Resident drink beyond one's capacity caused by liver
Damage, professor Hu Miaolin, which tests, confirms that antrodia has the effect of reducing SGPT and SGOT indexes, promotes liver cell regeneration.Pass through pharmacology
Experiment can raise GOT and GPT indexes in blood to big white mouse intraperitoneal injection APAP, and the GSH concentration of liver cell can also be reduced, SOD
And the enzyme activity of GPx also all declines.Antrodia camphorata ball can reduce GOT and GPT indexes, raise GSH concentration；SOD can be replied simultaneously
And the performance of the enzyme activity of the relative antioxidants enzyme such as GPx, truly have help for protection liver function.Taiwan normal university is studied
Personnel isolate class triterpenes Compound β from antrodia fructification has GPT values in the acute hepatopathy mouse blood of reduction.With male
Sprague-Dawley rats are research object, and result of study shows antrodia fructification due to good antioxidation activity,
There is significant protective effect to the acute liver damage of alcohol-induced.Hsiao [10] et al. researchs show with male ICR mouse
For research object, antrodia water extract can effectively protect CCl4 by adjusting antioxidation activity and radical scavenging activity
The chronic liver injury of induction.Lin [11] et al. investigates the liver-protecting activity of antrodia thalline using Wistar rats as research model, real
The liver fibrosis process that the results show Antrodia camphorata mycelium can effectively delay CCl4 to induce is tested, further researches show that this may
It is because the active material in antrodia thalline removes the living radical generated in liver.Professor Yan Guoqin, which tests, confirms antrodia
There is the ability for the liver lipid peroxidation for promoting liver antioxidative enzyme and inhibiting hepatic tissue, and reach liver protecting effect.
4.2.4 immunization Shen researchs are adjusted and find Sulphurenic isolated from antrodia fructification
Acid, Eburicoic acid, Dehydroeburicoic acid and Antcin C can be in the neutrophil cells and list of people
The quantity of white blood cell is adjusted by the generation of inhibitory activity oxygen system product in nucleus, is played the role of immunoregulatory.Cinnamomum kanahirai hay
In sesame fructification triterpene compound tool Cytotoxic effect and inhibit histamine releasing effect, for antiallergy have compared with
Good effect；Polysaccharides have the function of that bidirectional modulation is immunized, and in addition to energy strengthening immune system, can more adjust superfluous be immunized
Power.Therefore, the disease caused by immune system is too strong, antrodia all have significant therapeutic effect.Clinical case shows, largely
Antrodia user's curative effect shows that antrodia is also shown for disease of immune system such as erythematosus lupus, Leucoplakia, Atopic dermatitis
Go out surprising curative effect, predictable although its pharmacological mechanism is unknown, antrodia has immune system powerful effect；Separately
There is report, antrodia may additionally facilitate the activity of macrophage and lysosome, also can inhibit the synthesis of lymphocyte DNA, in addition, antrodia
Also influence T4 lymphocytes and change cellular immune function；It was found that the water-soluble polysaccharide component of antrodia liquid state fermentation thalline is with good
Good anti-inflammatory activity.Mouse macrophage RAW264.7 experiment in vitro show antrodia active polysaccharide ingredient by adjust IL-6,
IL-10 and iNOS gene activities inhibit the generation of mouse macrophage IL-6, IL-10, MPC-5, RANTES and NO, so as to reach
To anti-inflammatory effect.
4.3 Antrodia camphoratas are substantially nontoxic
Existing various documents are summarized, it is almost non-toxic to report Antrodia camphorata fructification.In the toxicity to Antrodia camphorata extract
In experiment, using giving SD mouse continuous gavage Antrodia camphoratas extract 30 days, after administration, plucking eyeball blood sampling, to do various blood normal
Rule measure, and take out liver kidney spleen and weigh, and do pathological examination to liver kidney taste intestines, and every result is showed no relevant different with medication
Often variation, main organs pathomorphism do not occur toxicity lesion, conclusion：(30 days) Antrodia camphorata extract continuous gavage has no for a long time
Overt toxicity reacts.
5. the use background of Antrodia camphorata, the medicinal efficacy of Antrodia camphorata has formal historical document to record, so far about more than 200 year.
Treasured island Taiwan residents and continent (south) common people are prevented and cured diseases with edible its for a long time obtains special effect.It is more so as to attract
Related scholar step on one after another to, comprehensive scientific research is expanded to Antrodia camphorata, summarize more than 200 piece research papers base
On plinth, show that Antrodia camphorata has following six kinds of effect scientific conclusions：(1) antioxidation, research find Antrodia camphorata extract
The content of the metabolite malonaldehyde (MDA) of activity and reduction free radical with enhancing super oxygen disproportionation ferment (SOD), simultaneously also
It can prevent glutathion inside cell and the loss of ATP.(2) tumor promotion effect, the examination of substantial amounts of Antrodia camphorata extract are inhibited
It tests as a result, it was confirmed that 1. by inhibiting or destroying Tumour DNA, the synthesis of RNA, to prevent tumor cell proliferation；2. by inhibiting thin
Born of the same parents' proliferation-inducing tumor cell differentiation or apoptosis；3. by the adjustment effect to immune function, body immune system is activated, can be limited
Growth of cancer cells processed；4. by drug-induced tumour cell to normal cell turnover, while to normal cell without lethal effect, and
The side effects such as rare bone marrow suppression；5. inhibition growth of tumour cell is played by the influence expressed tumor cell gene.(3)
Anti-hepatitis B virus effects, research find that Antrodia camphorata extract is thin to hepatitis B wild strain cell and lamivudine tolerance type
Born of the same parents are respectively provided with growth inhibition effect.(4) function for protecting liver and reducing enzyme activity is confirmed by pharmacological evaluation, and D-Galan is injected intraperitoneally to big white mouse
(D-galactosamine) causes hepatic injury mould, makes ALT and AST contents in rat model blood significantly raised, the GSH concentration of liver cell
It substantially reduces, the enzyme activity of SOD and GPx are decreased obviously.After oral Antrodia camphorata extract, it is big to can obviously reduce hepatic injury
ALT and AST contents in mouse blood significantly raise GSH concentration；The ferment of the relative antioxidants enzyme such as SOD and GPx can be replied simultaneously
Activity truly has help for protection liver function.(5) immune function is improved, Antrodia camphorata extract (polysaccharides ingredient) has double
To immune function is adjusted, in addition to energy strengthening immune system, superfluous immunity can be more adjusted.Therefore, immune system is too strong
Caused disease, antrodia all have significant therapeutic effect.Clinical case shows that substantial amounts of antrodia user curative effect is shown,
Antrodia also shows surprising curative effect for disease of immune system such as erythematosus lupus, Leucoplakia, Atopic dermatitis.Except the modern times
Outside to the scientific research of Antrodia camphorata, clinically with Antrodia camphorata extract make capsule for treating hepatopathy (hepatitis B and its liver cancer,
Hepatitis C is also effective) obtain the effect of peculiar (reduction virus load, ascites improve liver function, reduce carcinoma, inhibiting carcinoma
Generation).In addition to erythematosus lupus, Leucoplakia, Atopic dermatitis and leukaemia etc. caused by immune surplus.Also Cinnamomum kanahirai hay
Sesame is for reducing blood pressure, blood fat；Hyperglycaemia is reduced, is promoted blood circulation.
It these are only the preferred embodiment of the present invention, be not intended to limit the invention, for those skilled in the art
For member, the invention may be variously modified and varied.Any modification within the spirit and principles of the invention, being made,
Equivalent substitution, improvement etc., should all be included in the protection scope of the present invention.
Claims (7)
1. a kind of antrodia capsule formula, which is characterized in that including it is following by weight：
10 parts~500 parts of Antrodia camphorata powder.
2. antrodia capsule formula according to claim 1, which is characterized in that including it is following by weight：
50 parts~450 parts of the Antrodia camphorata powder.
3. antrodia capsule formula according to claim 2, which is characterized in that including it is following by weight：
100 parts~400 parts of the Antrodia camphorata powder.
4. antrodia capsule formula according to claim 3, which is characterized in that including it is following by weight：
150 parts~350 parts of the Antrodia camphorata powder.
5. antrodia capsule formula according to claim 4, which is characterized in that including it is following by weight：
200 parts~300 parts of the Antrodia camphorata powder.
6. antrodia capsule formula according to claim 5, which is characterized in that including it is following by weight：
250 parts of the Antrodia camphorata powder.
A kind of 7. method for making antrodia capsule, which is characterized in that comprise the following steps：
Fine powder will be ground into such as claim 1-6 any one of them Antrodia camphoratas, and crosses 120 mesh sieves, reuses filling machine filling
Capsule.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711460670.1A CN108096289A (en) | 2017-12-28 | 2017-12-28 | A kind of antrodia capsule formula and production method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201711460670.1A CN108096289A (en) | 2017-12-28 | 2017-12-28 | A kind of antrodia capsule formula and production method |
Publications (1)
| Publication Number | Publication Date |
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| CN108096289A true CN108096289A (en) | 2018-06-01 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201711460670.1A Pending CN108096289A (en) | 2017-12-28 | 2017-12-28 | A kind of antrodia capsule formula and production method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113491720A (en) * | 2020-03-18 | 2021-10-12 | 绿茵生技股份有限公司 | Application of antrodia camphorata for relieving alcoholism and/or increasing alcohol metabolism |
Citations (3)
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|---|---|---|---|---|
| CN202160620U (en) * | 2011-07-04 | 2012-03-14 | 郭宝玉 | Antrodia camphorate capsule |
| TWM481014U (en) * | 2013-11-08 | 2014-07-01 | Miyuan Biotech Co Ltd | Antrodia cinnamomea powder capsule structure for the treatment of tumor cells |
| TWM485048U (en) * | 2013-11-08 | 2014-09-01 | Miyuan Biotech Co Ltd | Antrodia cinnamomea powder capsule structure having anticancer and antioxidation functions |
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| CN202160620U (en) * | 2011-07-04 | 2012-03-14 | 郭宝玉 | Antrodia camphorate capsule |
| TWM481014U (en) * | 2013-11-08 | 2014-07-01 | Miyuan Biotech Co Ltd | Antrodia cinnamomea powder capsule structure for the treatment of tumor cells |
| TWM485048U (en) * | 2013-11-08 | 2014-09-01 | Miyuan Biotech Co Ltd | Antrodia cinnamomea powder capsule structure having anticancer and antioxidation functions |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113491720A (en) * | 2020-03-18 | 2021-10-12 | 绿茵生技股份有限公司 | Application of antrodia camphorata for relieving alcoholism and/or increasing alcohol metabolism |
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Application publication date: 20180601 |