CN108042899A - A kind of dual valve implantable drug delivery system - Google Patents
A kind of dual valve implantable drug delivery system Download PDFInfo
- Publication number
- CN108042899A CN108042899A CN201810069977.7A CN201810069977A CN108042899A CN 108042899 A CN108042899 A CN 108042899A CN 201810069977 A CN201810069977 A CN 201810069977A CN 108042899 A CN108042899 A CN 108042899A
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- Prior art keywords
- valve
- drug delivery
- conduit
- delivery system
- implantable drug
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/84—Drainage tubes; Aspiration tips
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
- A61M25/0074—Dynamic characteristics of the catheter tip, e.g. openable, closable, expandable or deformable
- A61M25/0075—Valve means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/005—Devices for introducing or retaining media, e.g. remedies, in cavities of the body for contrast media
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/105—Balloon catheters with special features or adapted for special applications having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/12—Blood circulatory system
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The present invention relates to a kind of dual valve implantable drug delivery systems, belong to medical instrument and field of medical materials.The implantable drug delivery system body is made of injection seat and connecting conduit, and injection seat is a hollow liquid storage warehouse, and passes through diaphragm and be connected with conduit.The front end valve of the system is located at the head end of conduit；Rear end valve is located at liquid storage warehouse and catheter connector position, i.e. notch on diaphragm.The system is applicable to tissue and Intravascular infusions chemotherapeutics, and when being operated without infusion or pumpback, valve is closed；It is infused or during pumpback, valve is opened.Another design concept of the system is to apply in local chemotherapy, it can additional closed sacculus in the head end of conduit, for storing radiotherapeutic drug, to realize the local treatment to tumour, the design of dual valve can prevent radiotherapy and chemotherapy medicine from, by sacculus reflux to conduit or liquid storage warehouse, avoiding damage of the radiotherapy and chemotherapy medicine leakage to human cuticular tissue.
Description
Technical field
The invention belongs to medical instruments and field of medical materials, and in particular to and it is a kind of that there is dual valve, can effectively it prevent
The only implantable drug delivery system of drug and blood back flow.
Background technology
In traditional medical procedure, artery administration, injection contrast agent, venous blood collection, anticancer radiotherapy and chemotherapy medicine whole body or office
Portion is administered and cranial cavity, thoracic cavity, and the treatment of intraperitoneal drainage takes plug in duct to carry out more, the treatment side of this direct cannulation
There are the problems such as easy infection, inconvenient, poor reliability, obstruction patient activity for formula.In the middle and later periods in 20th century, face both at home and abroad
Gradually using the device of a kind of implantable in vivo administration or drainage on bed, to solve the above problems.But this device is using
The problems such as often occurring the problem of drug and blood back flow in the process, and causing infection, plugging, thrombus, endangers patient health.For
Infection caused by can effectively prevent adverse current and damage of the radiotherapy and chemotherapy medicine to patient is reduced, the present invention, which proposes one kind, to be had
Dual valve, it can prevent the implantable drug delivery system backflowed.
Patent CN200998518Y describes a kind of micro-wound implanting type radiotherapy bursa, and device is made of three parts：Liquid reservoir is led
Pipe and storage anther sac.Liquid reservoir is hollow, oblate body, is connected with conduit.Catheter tip has several apertures, and end is by storage anther sac bag
It wraps up in.Liquid reservoir and conduit are made of silica gel, and liquid reservoir bottom liner is with thin stainless steel gasket.Reservoir is good by soft texture, elasticity
Good genuine milk rubber film is made, and wraps up catheter tip, forms closed blister cavities.Radionuclide can be imported using the device
Tumor by local.
Implantable drug delivery system described in patent CN201710803U discloses a kind of pump body structure, by gland and pedestal structure
It is in the wide inswept in rear end into, pedestal shape, central thick surrounding edge is flat thin, and by width to narrow and by thickness to thin streamlined mistake
The form crossed, the edge of pedestal are uniformly distributed there are three threading hole, and the middle part of base inner wall is equipped with step, is stamped and wears on step
Pierce membrane, pedestal and puncture and form chamber between membrane, gland is arranged on the edge for puncturing membrane, the bottom of gland be equipped with to
The collar of lower extension, collar is closely between the side wall at base openings end and puncture membrane.The patent advantage is：It is not easy to ooze
Leakage, it is solid and reliable.
Implanted peri-operative central venous infusion port disclosed in United States Patent (USP) US2011/0004167A1, port body structure and patent
CN201710803U is similar, and vein blood vessel is inserted in connecting conduit cooperation seal wire use, for chemotherapy or parenteral nutrition is needed to supplement
Patient's long-time service and patent CN206007700U provide a kind of full-implantation type venous transfusion port, for the defeated of puncture
Cylindric port body made of all silica gel in liquid port, entire port body can enter the entry point of body cavity as puncture needle, be implanted into skin
Transfusion port position need not be ajusted after lower, greatly improves puncture success rate.
The paper " chemotherapy of mesenchyma stroma of pernicious cerebral glioma " of Li Anmin et al. is published in《Chinese Clinical neurosurgery is miscellaneous
Will》, 1999,3, patient's encephalic is imbedded at using silica gel material brain colloid chemotherapy capsule in paper, malignant glioma is realized anti-
Multiple administration.Medical grade silicon rubber is the chemotherapy capsule of material, and histocompatbility is good, no antigen, high pressure resistant disinfection, anti-aging,
Elasticity is good, through external 300 no leakages of puncture test.Storage can be buried for a long time in vivo, repeat administration is easy.
Involved implantation infusion device in more than patent and document, is no valve structure or single valve structure,
Blood and drug adverse current can not be effectively solved the problems, such as in actual Clinical practice.With the extension of Implantation Time, easily occur by
In the severe complications such as infection, plugging and thrombus caused by blood and drug adverse current.The present invention is in conduit or sacculus
Liquid reflux problem, it is proposed that a kind of implantable drug delivery system with dual valve can effectively prevent drug reflux.
The content of the invention：
The present invention relates to a kind of dual valve implantable drug delivery system, feature is that main body is made of injection seat connecting conduit,
Injection seat generally silica gel material has good histocompatbility, and it is comfortable to be implanted into body-sensing；It is worn at the top of injection seat for an arc
Thorn is every puncturing and punctured and no leakage repeatedly every tolerable syringe needle；Injection seat internal cavities are communicated with conduit, and cavity bottom sets anti-
The gasket 5 that only syringe needle penetrates, material can be but be not limited to pure titanium, titanium alloy, stainless steel, platinum, polysulfones etc. and can stop point
The metal or rigid plastics of sharp pin puncture.
It is an advantage of the present invention that set valve respectively in the front and back end of the conduit, catheter proximal end is blind end, front end
Valve may be disposed at apart from port nearby, generally along the elongated streamline of conduit extending direction, shape such as " one " type,
" two " type, " three " type；Rear end of conduit is connected with injection seat, connecting portion there are one being socketed in diaphragm on rear end of conduit mouth,
Diaphragm membrane material can be silica gel, flexibel polyurethane, thermoelastic etc..
Valve is arranged on diaphragm using technologies such as laser cutting, physics cuttings, and is set according to different demands
The valve of different shape and size, such as " one " type, " ten " type, " two " type, " three " type, " " type, " ÷ " type.
Second design that this patent is specifically related to is applied in local chemotherapy, and closed sacculus can be socketed in catheter proximal end,
Balloon features can be the suitable models such as spherical, cylindrical, elliposoidal, irregular shape, for storing drug, realize to tumour
Local treatment, the design of dual valve can prevent radiotherapeutic drug from, by sacculus reflux to conduit or liquid storage warehouse, avoiding radiotherapeutic drug
The damage to leak outside to human cuticular tissue.
The Arcuate puncture every thickness should on the one hand ensure its puncture resistance, on the other hand for cavity reserve part sky
Between, more thin better guarantee integral thickness is subcutaneously implanted convenient for head, can be 1-4mm；
The dual valve material can be silica gel, flexibel polyurethane, hot engineering elastomer or other elastomeric macromolecule materials
Material, valve are closed under without infusion or pumpback mode of operation, and liquid in conduit or sacculus is prevented to backflow, being infused or
When pumpback operates, valve is in folding condition.
The length of the connecting conduit is 10cm-80cm, to be suitable for different position（In cranial cavity, in pericardium, blood vessel
It is interior, it is intraperitoneal, in alimentary canal or subcutaneous）Treatment.
The positive effect of the present invention is as follows：
The dual valve of the implantable drug delivery system without infusion or pumpback operate when close, infused or pumpback behaviour
When making, valve is in folding condition, have effects that it is dual it is anti-backflow, adopted suitable for artery administration, injection contrast agent, vein
Blood, anticancer radiotherapy and chemotherapy medicine are administered either systemically or locally, infection, plugging, thrombus or putting of reduction caused by can effectively prevent adverse current
Treat damage of the drug to patient.
Description of the drawings
Fig. 1 is the whole sectional view of the present invention
Fig. 2 is rear end of conduit sectional view
Fig. 3 is rear end of conduit valve-open and closed mode schematic diagram
Fig. 4 is catheter proximal end valve-open and closed mode schematic diagram
Fig. 5 is band sacculus drug delivery implant system schematic
Fig. 6 is valve schematic diagram in front end of different shapes
Fig. 7 is valve schematic diagram in rear end of different shapes
Fig. 8 is sacculus schematic diagram of different shapes
Reference sign：
1：Injection seat
2：Conduit
3：Sacculus
4：Arcuate puncture every
5：Gasket
6：Cavity
7：Front end
71：Front end valve
8：Rear end
81：Diaphragm
82：Rear end valve.
Specific embodiment
Embodiment 1
A kind of dual valve implantable drug delivery system as shown in Figs 1-4, is mainly used for tissue and intravascular input drug.It is wrapped
Injection seat 1, connecting conduit 2 are included, 1 one side opening of injection seat is connected with the openend 8 of conduit 2, and the top of injection seat 1 has arc to wear
Thorn is resistant to the multiple puncture of syringe needle, internal cavities 6 are communicated with catheter lumen, and drug enters conduit, 6 bottom of cavity by cavity every 4
There is gasket 5 in portion, and material uses pure titanium, pedestal is penetrated to limit syringe needle.
Invent the dual valve that is provided respectively positioned at the openend of conduit and blind end side wall, openend it is fixed one
Diaphragm membrane structure has a notch consistent with 2 extending direction of conduit apart from the position of catheter lock port side wall, forms a polyphyll
Membrane structure 7, valve 7 can be communicated when opening by tube wall with 2 inner cavity of conduit.The diaphragm and the material of conduit are silicon
Glue.
The system is applicable to tissue and intravascular input chemotherapeutics, when being operated without infusion or pumpback, valve
Film is closed；When being infused or pumpback operates, valve is in folding condition, and the design of dual valve can effectively be prevented
The only reflux of drug and blood.
Embodiment 2
Second design that this patent is specifically related to is applied in local chemotherapy, as shown in figure 5, can be outer in the front end of connecting conduit
Sacculus is closed in encryption, and the material of sacculus is nylon, for storing radiotherapeutic drug, realizes the local treatment to tumour.Practical operation
Cheng Zhong after drug is injected, often with 2 tube chamber of 1 inner cavity of normal saline flushing injection seat and conduit, makes drug pass through dual valve
Pressure is controlled completely into sacculus.The design of dual valve can prevent radiotherapeutic drug by sacculus reflux to conduit or liquid storage warehouse,
Avoid damage of the radiotherapeutic drug leakage to human cuticular tissue.
Embodiment 3
As shown in fig. 6, catheter proximal end set a valve, valve shape can be " one " type, " two " type, " three " type, rear end of conduit
Opening.
Table 1
| Front end valve shape | - | = | ≡ |
Embodiment 4
As shown in fig. 7, catheter proximal end opening, rear end sets a valve, and valve shape can be " one " type, " ten " type, " two " type,
" three " type, " " type, " ÷ " type.
Table 2
| Rear end valve shape | - | + | = | ≡ | · | ÷ |
Embodiment 5
There is valve in the front and back end of conduit, and the valve shape of Examples 1 and 2 is subject to random combine, you can obtains the present invention's
The various situations of embodiment 3.
Table 3
Embodiment 6
On the basis of embodiment 1,2,3, a closure sacculus is socketed in the front end of conduit, balloon features can be spherical, cylinder
Shape, such as elliposoidal, Fig. 8.
Embodiment 7
The catheter length can be 10cm- 80cm；Different treatment positions are applicable to, intravascular in pericardium in cranial cavity, abdomen
Intracavitary, in alimentary canal or subcutaneous.
Specific embodiments of the present invention have been described above, it will be appreciated by those of skill in the art that this is only to illustrate
Illustrate, protection scope of the present invention is defined by the appended claims.Those skilled in the art is without departing substantially from the present invention
Principle and essence under the premise of, numerous variations or change can be made to these embodiments, but these change and modification fall
Enter protection scope of the present invention.
Claims (9)
1. a kind of dual valve implantable drug delivery system, which is characterized in that the implantable drug delivery system body is by injection seat 1
It is formed with connecting conduit 2, injection seat is hollow structure, as liquid storage warehouse, and passes through diaphragm and is connected with conduit；Described is double
Polyphyll film implantable drug delivery system has dual valve structure, and the front end that front end valve is located at conduit is leaned near head end, rear end valve
Film is located at liquid storage warehouse and catheter connector position, and passes through a diaphragm with notch and be connected, the notch shape on diaphragm
Into valve structure；Second design that this patent is specifically related to is applied in local chemotherapy, can be additional in the front end of connecting conduit
Closed sacculus, it is dual to prevent reflux valve for storing radiotherapeutic drug, it is possible to reduce radiopharmaceuticals reflux is more concentrated on ball
Capsule realizes the local treatment to tumour；Radiotherapy isotope drug reflux is reduced to containing liquid chamber, causes local tissue damage.
2. a kind of dual valve implantable drug delivery system as described in claim 1, which is characterized in that the diaphragm and lead
The material of pipe is silica gel, flexibel polyurethane, hot engineering elastomer or other high resiliency macromolecules.
3. a kind of dual valve implantable drug delivery system as described in claim 1, which is characterized in that described to be arranged at diaphragm
On valve, shape can be " one " type, " ten " type, " two " type, " three " type, " " type, " ÷ " type or other can realize and prevent
Liquid backflows the shape of function.
A kind of 4. dual valve implantable drug delivery system as described in claim 1, which is characterized in that the valve of the conduit head end
Film shape can be " one " type, " two " type, " three " type.
A kind of 5. dual valve implantable drug delivery system as described in claim 1, which is characterized in that the thickness punctured every 4
Degree is in 1-4mm.
6. a kind of dual valve implantable drug delivery system as described in claim 1, which is characterized in that 5 material of gasket is not
It is limited to metal or rigid plastics that pure titanium, titanium alloy, stainless steel, polysulfones etc. can stop sharp pin puncture.
7. a kind of dual valve implantable drug delivery system as described in claim 1, which is characterized in that catheter proximal end can connect one
A closed sacculus, for storing drug, material can be silica gel, thermoelastic, polyurethane, nylon（Polyamide, PA）Or
Other high molecular materials.
8. a kind of dual valve implantable drug delivery system as described in claim 1, which is characterized in that the sacculus is spherical shape,
Cylinder, elliposoidal or other suitable shapes.
9. a kind of dual valve implantable drug delivery system as described in claim 1, which is characterized in that 2 length of conduit is
10cm-80cm, to be suitable for different position（It is intravascular in pericardium in cranial cavity, it is intraperitoneal, in alimentary canal or subcutaneous）
Treatment.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810069977.7A CN108042899A (en) | 2018-01-24 | 2018-01-24 | A kind of dual valve implantable drug delivery system |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810069977.7A CN108042899A (en) | 2018-01-24 | 2018-01-24 | A kind of dual valve implantable drug delivery system |
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| Publication Number | Publication Date |
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| CN108042899A true CN108042899A (en) | 2018-05-18 |
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| CN201810069977.7A Pending CN108042899A (en) | 2018-01-24 | 2018-01-24 | A kind of dual valve implantable drug delivery system |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111494751A (en) * | 2020-06-02 | 2020-08-07 | 山东威高集团医用高分子制品股份有限公司 | Implantable drug delivery device |
| CN111588974A (en) * | 2020-06-19 | 2020-08-28 | 刘宣力 | Disposable heart catheter panoramic endoscopic and drug administration device |
| CN111659020A (en) * | 2020-06-11 | 2020-09-15 | 福建医科大学附属第一医院 | Diagnostic device for brain glioma |
| CN112569457A (en) * | 2020-12-10 | 2021-03-30 | 北京大学第三医院（北京大学第三临床医学院） | Continuous drug delivery bag tube system |
| CN114432536A (en) * | 2022-01-29 | 2022-05-06 | 深圳道远医疗科技有限公司 | Integrated device and method for dynamic blood glucose monitoring and insulin injection fusion |
| CN115554518A (en) * | 2022-10-28 | 2023-01-03 | 中国人民解放军空军军医大学 | Subcutaneous administration device for preoperative chemotherapy |
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| CN2248569Y (en) * | 1996-04-16 | 1997-03-05 | 粟祜 | Device for introducing media into the body by inserting skin of anti-back-flow type |
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| CN200998518Y (en) * | 2006-11-03 | 2008-01-02 | 刘爱军 | Micro-wound implanting type radiotherapy bursa |
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| CN106215276A (en) * | 2016-08-31 | 2016-12-14 | 北京兆仕医疗器械有限责任公司 | A kind of subarachnoid space epidural canalis spinalis doser |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111494751A (en) * | 2020-06-02 | 2020-08-07 | 山东威高集团医用高分子制品股份有限公司 | Implantable drug delivery device |
| CN111659020A (en) * | 2020-06-11 | 2020-09-15 | 福建医科大学附属第一医院 | Diagnostic device for brain glioma |
| CN111588974A (en) * | 2020-06-19 | 2020-08-28 | 刘宣力 | Disposable heart catheter panoramic endoscopic and drug administration device |
| CN112569457A (en) * | 2020-12-10 | 2021-03-30 | 北京大学第三医院（北京大学第三临床医学院） | Continuous drug delivery bag tube system |
| CN112569457B (en) * | 2020-12-10 | 2024-02-13 | 北京大学第三医院（北京大学第三临床医学院） | Continuous administration cyst tube system |
| CN114432536A (en) * | 2022-01-29 | 2022-05-06 | 深圳道远医疗科技有限公司 | Integrated device and method for dynamic blood glucose monitoring and insulin injection fusion |
| CN115554518A (en) * | 2022-10-28 | 2023-01-03 | 中国人民解放军空军军医大学 | Subcutaneous administration device for preoperative chemotherapy |
| CN115554518B (en) * | 2022-10-28 | 2024-05-31 | 中国人民解放军空军军医大学 | Subcutaneous drug delivery device for preoperative chemotherapy |
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