CN108031975A - A kind of induced with laser implantation preparation method of continuous multilayer drop parcel - Google Patents
A kind of induced with laser implantation preparation method of continuous multilayer drop parcel Download PDFInfo
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- CN108031975A CN108031975A CN201711003709.7A CN201711003709A CN108031975A CN 108031975 A CN108031975 A CN 108031975A CN 201711003709 A CN201711003709 A CN 201711003709A CN 108031975 A CN108031975 A CN 108031975A
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- 238000002360 preparation method Methods 0.000 title claims abstract description 28
- 238000002513 implantation Methods 0.000 title claims description 11
- 239000011521 glass Substances 0.000 claims abstract description 30
- 239000000758 substrate Substances 0.000 claims abstract description 29
- 238000003780 insertion Methods 0.000 claims abstract description 9
- 230000037431 insertion Effects 0.000 claims abstract description 9
- 230000005855 radiation Effects 0.000 claims abstract description 9
- 230000015556 catabolic process Effects 0.000 claims abstract description 3
- 239000007788 liquid Substances 0.000 claims description 33
- 230000015572 biosynthetic process Effects 0.000 claims description 12
- 230000033001 locomotion Effects 0.000 claims description 7
- 239000007787 solid Substances 0.000 claims description 5
- 230000000694 effects Effects 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 3
- 239000000725 suspension Substances 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 12
- 238000012546 transfer Methods 0.000 abstract description 2
- 239000012071 phase Substances 0.000 description 8
- 238000006243 chemical reaction Methods 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 238000013461 design Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 230000009471 action Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000004528 spin coating Methods 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000004205 dimethyl polysiloxane Substances 0.000 description 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000010030 laminating Methods 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 239000011859 microparticle Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 238000004987 plasma desorption mass spectroscopy Methods 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 239000013077 target material Substances 0.000 description 1
- 230000005514 two-phase flow Effects 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
- B23K26/00—Working by laser beam, e.g. welding, cutting or boring
- B23K26/352—Working by laser beam, e.g. welding, cutting or boring for surface treatment
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- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Plasma & Fusion (AREA)
- Mechanical Engineering (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Joining Of Glass To Other Materials (AREA)
Abstract
Induced with laser the invention discloses a kind of continuous multilayer drop parcel is implanted into preparation method, includes the following steps：S1：The preparation of a variety of media；S2：The laser beam (1) of pulse is from glass substrate (3) vertical incidence, laser beam (1) passes through glass substrate (3), focus on the one side of the first layer dielectric layer (4), when the energy of laser beam (1) is more than the breakdown threshold of first layer medium (4), the plasma (2) of high temperature and pressure, plasma (2) external radiation blast wave will be produced；S3：Externally radiation blast wave promotes first layer dielectric layer (4) to form molten melt drop (5) to plasma (2), in the second layer medium (6) and third layer dielectric layer (7) of the embedded lower section of molten melt drop (5), multilayer drop insertion (8) is formed.The present invention obtains two layers uniform in size controllable, can precisely to be manipulated to single drop or the drop parcel of multilayer by induced with laser transfer techniques forward.
Description
Technical field
The present invention relates to a kind of induced with laser be implanted into preparation method, more particularly to a kind of continuous multilayer drop parcel swash
Photoinduction is implanted into preparation method.
Background technology
The drop technique for packing of fine volume is detected in biologic medical, molecular biology, and chemical industry chemistry, Food Science, changes
There is very big application value in the field such as cosmetic application and engineer application.The drop of fine volume can be as the miniature of chemical reaction
Reactor, the medicine package shipment of medical treatment and release, the unicellular progress biological detection analysis of parcel, the digitlization based on drop
PCR (PCR), organizational project, diagnosing image and other Engineerings apply [1].Micro-fluidic chip generates at present
Drop is main drop formation mode, and drop is as a kind of new fluid motion occurred in recent years on micro-fluidic chip
Form, each drop can be considered as independent microreactor, study the reaction on micro-dimension and its process.Apply upper
State in application field, based on drop, the materials such as the macromoleculars such as chemical reagent, cell, protein, microparticle can be carried out
Manipulation, the experiment condition of each reaction of more precise control, more flexible control participate in the actual use of each component of reaction
Amount, shortens the reaction time.
Specific drop formation principle：Drop is produced using two kinds of immiscible liquid in micro-fluidic chip, is with it
A kind of middle liquid is as continuous phase, using another liquid as dispersed phase, is manipulated by the channel design and external force of chip,
Dispersed phase can be cut into uniform micro volume unit and is scattered in continuous phase by continuous phase, that is, form drop.In micro-fluidic core
On piece can make that the droplet size of generation is homogeneous, property is stable, composition is uniform by controlling two-phase flow velocity.Drop formation method
Mainly multiphase flow method, makes dispersed phase fluid produce velocity variations ladder in path partially by the design to fluid channel structure
Degree, drop is generated using the interaction of the shearing force between two-phase, stickiness power and surface tension.Multiphase flow method can batch
Generate drop, easily carry out overall manipulation to batch drop, shortcoming be to the shell thickness or internal chamber structure of single drop and
The accuracy controlling of component etc.[2].According to the difference of PDMS base micro fluidic device geometries and liquid phase fluid flow direction
Difference, the generation of microlayer model can be divided into following 5 kinds of citation forms：(1) two-dimentional extrusion structure；(2) T types microchannel；(3) flow
Focus type microchannel；(4) common focus type microchannel；(5) Y types microchannel (as shown in Fig. 3 a-h).Built with glass capillary
Micro fluidic device can be divided into single emulsion drop and two kinds of structures of emulsion drop (such as Fig. 3 i-k institutes again according to the diversity of nested structure
Show)[3]。
Then the generation type of drop is together in series when needing the multilayer of drop to wrap up to obtain multilayer drop bag
Wrap up in, as shown in Figure 4.
The shortcomings that prior art：Existing micro-fluidic chip controls droplet size, liquid by controlling the speed of dispersed phase
It is relatively low to drip the uniformity, and needs to sort；It is difficult to the essence of the shell thickness or internal chamber structure and component etc. to single drop
Really regulation and control；A kind of micro-fluidic chip only corresponds to a kind of drop of size.
The content of the invention
It is an object of the invention to propose that a kind of induced with laser of continuous multilayer drop parcel is implanted into preparation method, pass through
Induced with laser transfer techniques forward, obtain uniform in size controllable, and the parcel number of plies, thickness are controllable, and parcel material optionally can be to list
Precisely manipulate two layers of a drop or the drop of multilayer parcel.
The technical solution adopted in the present invention：A kind of induced with laser implantation preparation method of continuous multilayer drop parcel, bag
Include following steps：
S1：The preparation of a variety of media：Specially apply on a glass substrate and scrape first layer dielectric layer (4), in the first layer
Storing apparatus is equipped with below dielectric layer (4), the storing apparatus is equipped with second dielectric layer (6) successively from top to bottom, third layer is situated between
Matter layer (7) and the 4th layer of dielectric layer (10)；
S2：The laser beam (1) of pulse passes through glass substrate from glass substrate (3) vertical incidence, laser beam (1)
(3), the one side of the first layer dielectric layer (4) is focused on, when the energy of laser beam (1) is more than hitting for first layer medium (4)
When wearing threshold value, it will produce the plasma (2) of high temperature and pressure, plasma (2) external radiation blast wave；
S3：Externally radiation blast wave promotes first layer dielectric layer (4) to form molten melt drop (5), melting to plasma (2)
In the second layer medium (6) and third layer dielectric layer (7) of the embedded lower section of drop (5), multilayer drop insertion (8) is formed；Formed
Multilayer drop insertion (8) is ejected into the 4th layer of dielectric layer (10) further along, due to the stickiness of the 4th layer of dielectric layer (10)
The effect of power and surface tension and then formation multilayer drop parcel (9), make multilayer liquid under the resistance of the 4th layer of dielectric layer (10)
Drop parcel (9) driving force slows down, and ultimately forms complete drop；
S4：Glass substrate (3) movement, repeat step S2, S3 are driven by preset direction；Complete the system of multilayer drop
It is standby.
Preferably, the first layer dielectric layer (4) is liquid, suspension or solid film containing attritive powder.
Preferably, the second dielectric layer (6), third layer dielectric layer (7) and the 4th layer of dielectric layer (10) are different densities
Liquid.
Preferably, the movement of the glass substrate (3) is driven described in step S4 by preset direction, is specially：With parallel to
Axis centered on the default straight line in laser beam (1) direction, drives the glass substrate (3) to move by circumferencial direction.
Preferably, the density of the second dielectric layer (6) is less than the density of third layer dielectric layer (7), and the third layer is situated between
The density of matter layer (7) is less than the density of the 4th layer of dielectric layer (10).
Preferably, the laser beam (1) is fixed on above the glass substrate (3).
Compared with prior art, the beneficial effects of the invention are as follows：(1) laser beam (1) induction of the present invention produces plasma
Body (2) promotes the first layer dielectric layer (4) for being applied to glass substrate to pass through the layer liquid generation multilayer drop bag in storing apparatus
Wrap up in, by adjusting change laser energy, the number of plies, thickness and the material of focus spot diameter and sample preparation obtain different rulers
The multilayer drop that single drop can be precisely the manipulated parcel of very little, the different numbers of plies, a variety of materials of different Jacket thickness；
(2) the method for the present invention can continuously generate the drop parcel of multilayer；Can be more to realize by adjusting laser parameter and sample preparation
The drop parcel of the more sizes of thickness；(3) the droplet size size uniform of the method for the present invention generation；(4) method of the invention can be right
Single drop is precisely manipulated, is avoided the difficulty of liquid spin coating, simplifies the process that multilayer liquid prepares spin coating；(5) originally
Inventive method is not limited solely to the parcel of liquid and liquid, and liquid on glass substrate can also be changed into solid target can realize
The parcel of solid and liquid, has the advantages that high throughput, formation efficiency are high, manufacturing cost is low etc..
Brief description of the drawings
Fig. 1 is the schematic diagram that a kind of induced with laser of continuous multilayer drop parcel of the present invention is implanted into preparation method.
Fig. 2 is the preparation principle figure that the present invention automatically generates multilayer liquid.
Fig. 3 is microlayer model generating means schematic diagram common in the art.
Fig. 4 is that the series connection of droplet formation forms multilayer drop parcel schematic diagram.
Embodiment
Technical scheme is further illustrated with reference to specific embodiment.
As shown in Figs. 1-2, the induced with laser implantation preparation method of a kind of continuous multilayer drop parcel, includes the following steps：
S1：The preparation of a variety of media：Specially apply on a glass substrate and scrape first layer dielectric layer (4), in the first layer
Storing apparatus is equipped with below dielectric layer (4), the storing apparatus is equipped with second dielectric layer (6) successively from top to bottom, third layer is situated between
Matter layer (7) and the 4th layer of dielectric layer (10)；
S2：The laser beam (1) of pulse passes through glass substrate from glass substrate (3) vertical incidence, laser beam (1)
(3), the one side of the first layer dielectric layer (4) is focused on, when the energy of laser beam (1) is more than hitting for first layer medium (4)
When wearing threshold value, it will produce the plasma (2) of high temperature and pressure, plasma (2) external radiation blast wave；
S3：Externally radiation blast wave promotes first layer dielectric layer (4) to form molten melt drop (5), melting to plasma (2)
In the second layer medium (6) and third layer dielectric layer (7) of the embedded lower section of drop (5), multilayer drop insertion (8) is formed；Formed
Multilayer drop insertion (8) is ejected into the 4th layer of dielectric layer (10) further along, due to the stickiness of the 4th layer of dielectric layer (10)
The effect of power and surface tension and then formation multilayer drop parcel (9), make multilayer liquid under the resistance of the 4th layer of dielectric layer (10)
Drop parcel (9) driving force slows down, and ultimately forms complete drop；
S4：Glass substrate (3) movement, repeat step S2, S3 are driven by preset direction；Complete the system of multilayer drop
It is standby.
In the concrete technical scheme of the present invention, the first layer dielectric layer (4) is outstanding for liquid, containing attritive powder
Turbid or solid film；The second dielectric layer (6), third layer dielectric layer (7) and the 4th layer of dielectric layer (10) are different densities
Liquid；The density of the second dielectric layer (6) is less than the density of third layer dielectric layer (7), the third layer dielectric layer (7)
Density be less than the density of the 4th layer of dielectric layer (10).The species and quantity of first layer dielectric layer (4) can be according to actual need
Make choice, generally at least two kinds；The second dielectric layer (6), third layer dielectric layer (7) and the 4th layer of dielectric layer
(10) it is liquid, even laminating is produced in storing apparatus using the physical action between liquid and liquid or chemical action.
Further, the movement of the glass substrate (3) is driven described in step S4 by preset direction, is specially：With parallel
The axis centered on the default straight line in laser beam (1) direction, drives the glass substrate (3) to move by circumferencial direction, described to swash
Light light beam (1) is fixed on above the glass substrate (3).
It should be noted that the laser beam (1) of pulse passes through glass from glass substrate (3) vertical incidence, laser (1)
Substrate (3), focuses on the one side for scribbling first layer dielectric layer (4), when laser energy is more than the breakdown of first layer dielectric layer (4)
During threshold value, it will produce the plasma (2) of high temperature and pressure, plasma (2) external radiation blast wave；Laser beam (1) wink
When high energy promote first layer dielectric layer (4) to form second dielectric layer (6) and the third layer Jie of the embedded lower section of molten melt drop (5)
In matter layer (7), multilayer drop insertion (8) is formed；The multilayer drop insertion (8) of formation is ejected into the 4th layer of Jie further along
In matter layer (10), effect and then formation multilayer drop parcel (9) due to Liquid Viscous power and surface tension.
Automatically generate the preparation principle of multilayer liquid：As shown in Fig. 2, in order to avoid difficulty prepared by liquid target material, this is specially
Profit produces uniform second dielectric layer (6) and the in a reservoir using the physical action between liquid and liquid or chemical action
Three layers of dielectric layer (7), when molten melt drop (5) passes through second dielectric layer (6) and third layer dielectric layer (7) since liquid has
Mobility can automatically form uniform layer liquid, and thus circulation can realize the preparation for automatically generating multilayer conforming layer liquid, from
And simplify the process for preparing multilayer liquid parcel.
Continuous multilayer drop wraps up implementation：As shown in Fig. 2, the laser beam (1) of fixed pulse, with glass substrate
(3) be used as turntable, it is rotating by direction of rotation (A) cycle in a manner of rotate the glass substrate (3) for scribbling first layer dielectric layer (4),
Step S2-S4 is carried out, is embedded into the diverse location formation molten melt drop (5) that laser beam acts on first layer dielectric layer (4)
Second dielectric layer (6), third layer dielectric layer (7) and the 4th layer of dielectric layer (10), so that continuous preparation multilayer liquid can be realized
The parcel of drop, improves the preparation efficiency of multilayer drop parcel.
For those skilled in the art, technical solution that can be as described above and design, make other each
Kind is corresponding to be changed and deforms, and all these change and deform the protection that should all belong to the claims in the present invention
Within the scope of.
Claims (7)
- A kind of 1. induced with laser implantation preparation method of continuous multilayer drop parcel, it is characterised in that：Include the following steps：S1：The preparation of a variety of media：Specially apply on a glass substrate and scrape first layer dielectric layer (4), in the first layer medium Storing apparatus is equipped with below layer (4), the storing apparatus is equipped with second dielectric layer (6), third layer dielectric layer successively from top to bottom (7) and the 4th layer of dielectric layer (10)；S2：For the laser beam (1) of pulse from glass substrate (3) vertical incidence, laser beam (1) passes through glass substrate (3), focuses on In the one side of the first layer dielectric layer (4), when the energy of laser beam (1) is more than the breakdown threshold of first layer medium (4), The plasma (2) of high temperature and pressure, plasma (2) external radiation blast wave will be produced；S3：Externally radiation blast wave promotes first layer dielectric layer (4) to form molten melt drop (5), molten melt drop to plasma (2) (5) in the second layer medium (6) and third layer dielectric layer (7) of embedded lower section, multilayer drop insertion (8) is formed；The multilayer of formation Drop insertion (8) be ejected into further along in the 4th layer of dielectric layer (10), due to the 4th layer of dielectric layer (10) stickiness power and The effect of surface tension and then formation multilayer drop parcel (9), make multilayer drop bag under the resistance of the 4th layer of dielectric layer (10) Wrap up in (9) driving force to slow down, ultimately form complete drop.
- A kind of 2. induced with laser implantation preparation method of continuous multilayer drop parcel according to claim 1, it is characterised in that： Further include S4：Glass substrate (3) movement, repeat step S2, S3 are driven by preset direction；Complete the preparation of multilayer drop.
- A kind of 3. induced with laser implantation preparation method of continuous multilayer drop parcel according to claim 1, it is characterised in that： The first layer dielectric layer (4) is liquid, suspension or solid film containing attritive powder.
- A kind of 4. induced with laser implantation preparation method of continuous multilayer drop parcel according to claim 1, it is characterised in that： The second dielectric layer (6), third layer dielectric layer (7) and the 4th layer of dielectric layer (10) are the liquid of different densities.
- A kind of 5. induced with laser implantation preparation method of continuous multilayer drop parcel according to claim 2, it is characterised in that： The movement of the glass substrate (3) is driven described in step S4 by preset direction, is specially：With parallel to laser beam (1) direction Default straight line centered on axis, drive the glass substrate (3) to move by circumferencial direction.
- A kind of 6. induced with laser implantation preparation method of continuous multilayer drop parcel according to claim 1, it is characterised in that： The density of the second dielectric layer (6) is less than the density of third layer dielectric layer (7), and the density of the third layer dielectric layer (7) is small In the density of the 4th layer of dielectric layer (10).
- A kind of 7. induced with laser implantation preparation method of continuous multilayer drop parcel according to claim 1, it is characterised in that： The laser beam (1) is fixed on above the glass substrate (3).
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| Application Number | Priority Date | Filing Date | Title |
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| CN201711003709.7A CN108031975B (en) | 2017-10-24 | 2017-10-24 | Laser-induced implantation preparation method for continuous multilayer liquid drop wrapping |
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| CN201711003709.7A CN108031975B (en) | 2017-10-24 | 2017-10-24 | Laser-induced implantation preparation method for continuous multilayer liquid drop wrapping |
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| CN108031975B CN108031975B (en) | 2020-02-21 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113340693A (en) * | 2021-06-17 | 2021-09-03 | 重庆大学 | Photo-thermal control liquid drop three-dimensional migration device and using method |
| CN113617399A (en) * | 2020-05-06 | 2021-11-09 | 苏州国科均豪生物科技有限公司 | Disposable injection high-efficiency micro-fluidic detection chip |
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| CN113340693A (en) * | 2021-06-17 | 2021-09-03 | 重庆大学 | Photo-thermal control liquid drop three-dimensional migration device and using method |
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| CN108031975B (en) | 2020-02-21 |
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