CN108014199A - A kind of Chinese medicine composition for treating donkey acute gastric dilatation and preparation method thereof - Google Patents
A kind of Chinese medicine composition for treating donkey acute gastric dilatation and preparation method thereof Download PDFInfo
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- 239000003814 drug Substances 0.000 title claims abstract description 39
- 230000001154 acute effect Effects 0.000 title claims abstract description 27
- 208000001762 Gastric Dilatation Diseases 0.000 title claims abstract description 24
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- 239000000203 mixture Substances 0.000 title claims abstract description 14
- 240000004980 Rheum officinale Species 0.000 claims abstract description 13
- 235000008081 Rheum officinale Nutrition 0.000 claims abstract description 13
- 239000000843 powder Substances 0.000 claims abstract description 13
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A61K2236/50—Methods involving additional extraction steps
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- A61K2236/50—Methods involving additional extraction steps
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Abstract
The present invention relates to a kind of Chinese medicine composition for treating donkey acute gastric dilatation and preparation method thereof, it is prepared by rheum officinale, Cortex Magnoliae Officinalis, the dried immature fruit of citron orange, saltcake, the membrane of a chicken's gizzard, radish seed and dried orange peel.Its preparation process is：(1) Chinese medicine is crushed to 30 80 mesh, is weighed by formula ratio, three-dimensional hybrid obtains traditional Chinese medicine powder；(2) mixed traditional Chinese medicine powder is put into extractor, when adding 5 15 times of amount boilings 2 12 small；(3) dregs of a decoction are filtered to remove, gained filtrate indwelling is spare；(4) dregs of a decoction are put into extractor again, when adding 5 10 times of amount boilings 2 10 small；(5) dregs of a decoction are filtered to remove, gained liquid merges with first time extracting liq；For (6) 30 100 DEG C of extracting solutions that are concentrated under reduced pressure to original volume 10% 50%, filtering and removing slag are filling, obtain finished product.Chinese medicine composition provided by the present invention has the effect of consumer product dredge stasis, drastic purgation thermojunction, relieving distension and oppression, stomach strengthening and digestion promoting, promoting qi circulation and relieving pain, and treatment donkey acute gastric dilatation cure rate is up to 90%.
Description
Technical field
The invention belongs to Chinese veterinary drug preparation field, especially a kind of Chinese medicine composition and its system for treating donkey acute gastric dilatation
Preparation Method.
Background technology
Donkey acute gastric dilatation Chinese veterinarian claims big tripe knot, is due to that donkey feeding is excessive, obstacle, pylorus occur for the digestive function of stomach
There is convulsive contraction, or due to intestinal occlusion, content cannot after give, stomach is drastically expanded, with fall ill drastically, the course of disease
Short, abdominal pain acutely, constitutional symptom be drastically characterized, such as treat not in time, easily cause gastric rupture or stomach rupture of diaphragm, cause dead
Die.
It can be divided into two kinds of primary and Secondary cases by its cause of disease.Primary Gastric expansion it is more because donkey it is excessive eaten indigestibility,
Easily expansion and forage easy to ferment, product cause the function of stomach to occur obstacle in stomach, and cannot after send in intestines, stomach occurs and expands
.The more processes secondary to the disease such as intestines constipation particularly small intestine constipation, enteric metachoresis, stomach shape bulb constipation of Secondary cases dilatation of the stomach
In, during these abdominal pain diseases, since small intestine is obstructed, the front of intestinal obstructions, gastric juice and intestinal fluid are largely secreted, and
The anastalsis of intestinal tube, makes a large amount of intestinal juice and part intestinal contents return in stomach, makes stomach excessively swollen full and dilatation of the stomach occurs.
Early stage symptom unobvious, performance mental distress, when and kick abdomen, have slight intermittent colic symptoms, quickly
Switch to typical dilatation of the stomach symptom, show as spirit uneasiness, suddenly get impatient sleeping, be intended to crouch without sleeping, sleepingly with caution, later sight abdomen, rolling
Turn, indivedual donkeys be in sitting position of dog gesture, and when movement, which carries on the back, slightly arches, the tormina symptoms such as small step whips.After gastric rupture, whole body profuse sweating,
Sweat are along four limbs.From gastric rupture to dead generally in 1-3h, donkey it is more it is slow-witted it is vertical in bites the dust suddenly, a small number of donkeys, which crouch, to struggle behind ground
It is dead for a moment.
Treatment donkey acute gastric dilatation at present alleviates pyloric spasm, analgesia stops ferment and recovers stomach work(to eliminate dilatation of the stomach state
Based on energy, fluid infusion cardiac stimulant, the principle of reatment supplemented by intensive care.But a large amount of Western medicine purgatives of perfusion, may cause body to be dehydrated,
So as to cause, sb.'s illness took a turn for the worse.Chinese medicine is aided with stomach strengthening and digestion promoting, the ministerial drug of tonifying middle-Jiao and Qi, can effectively avoid big based on heat and toxic materials clearing away
Just it is dilute half congealed, and diarrhea is terminated, stomach will not be damaged, therefore be badly in need of exploitation one kind can effectively treat donkey acute gastric dilatation
Chinese medicine preparation.
The content of the invention
The problem to be solved in the present invention is：Overcome the deficiencies of the prior art and provide one kind and treat donkey acute gastric dilatation curative effect
Exact natural Chinese traditional medicines composition.
Another technical problem to be solved by the present invention is that：A kind of Chinese medicine preparation for treating donkey acute gastric dilatation is provided.
Another technical problem to be solved by the present invention is that：The preparation method of above-mentioned Chinese medicine composition aqua is provided.
In order to solve the above technical problems, the technical solution adopted by the present invention is：A kind of Chinese medicine for treating donkey acute gastric dilatation
Composition, it is characterised in that：It is prepared by the raw material of following mass fraction：12-18 parts of rheum officinale, 20-32 parts of Cortex Magnoliae Officinalis, the dried immature fruit of citron orange
12-16 parts, 10-15 parts of saltcake, 10-18 parts of the membrane of a chicken's gizzard, 7-12 parts of radish seed, 7-12 parts of dried orange peel.
Further, the mass fraction of the optimum feed stock of the Chinese medicine composition is as follows：12 parts of rheum officinale, 24 parts of Cortex Magnoliae Officinalis, the dried immature fruit of citron orange
12 parts, 10 parts of saltcake, 18 parts of the membrane of a chicken's gizzard, 12 parts of radish seed, 12 parts of dried orange peel.
Further, which is the various conventional extract oral medicine preparations for containing or not contain pharmaceutic adjuvant
Form.
Further, the preparation can be aqua.
Further, the preparation method of said composition aqua is：(1) Chinese medicine is crushed to 30-80 mesh, claimed by formula ratio
Take, three-dimensional hybrid obtains traditional Chinese medicine powder；(2) mixed traditional Chinese medicine powder is put into extractor, add 5-15 times measure boiling 2-12 it is small when；
(3) dregs of a decoction are filtered to remove, gained filtrate indwelling is spare；(4) dregs of a decoction are put into extractor again, adds 5-10 times to measure boiling 2-
10 it is small when；(5) dregs of a decoction are filtered to remove, gained liquid merges with first time extracting liq；(6) the 30-100 DEG C of extracting solution that is concentrated under reduced pressure
To original volume 10%-50%, filtering and removing slag are filling, obtain finished product.
The present invention has the advantages and positive effects of：
(1) this prescription is according to tcm theory, scientific compatibility, selects with heat and toxic materials clearing away, relieving distension and oppression, stomach strengthening and digestion promoting, OK
The natural Chinese medicinal herb for the effect of gas relieves pain, a kind of Chinese medicinal aqua is made using Standardization Process.Through clinical examination, the Chinese medicinal aqua
Donkey acute gastric dilatation cure rate is treated up to 90%.
(2) pharmacology of each Chinese medicine material of the present invention is：
Rheum officinale：Heat and toxic materials clearing away, cleanses stomach；
Cortex Magnoliae Officinalis：During lower gas is wide, consumer product dredge stasis；
The dried immature fruit of citron orange：Relieving stagnant Qi removes ruffian, consumer product dredge stasis；
Saltcake：Heat and toxic materials clearing away, moistening for dryness and softening hard mass；
The membrane of a chicken's gizzard：Food digesting stomach fortifying；
Radish seed：Help digestion and eliminate flatulence；
Dried orange peel：Promoting qi circulation and relieving pain, invigorating spleen.
Among formula, rheum officinale purgating heat and bowels, can cleanse stomach, push away Chen Zhixin, and treating stagnant constipation has special efficacy, and because it is bitter
Cold sedimentation, it is kind to expel the heat-evil, it is particularly suitable to real heat constipation.Saltcake heat and toxic materials clearing away, heat-clearing cold in nature, the salty moistening for dryness and softening hard mass of taste, to damp and hot
Stagnant, dry feces person is particularly suitable, with rheum officinale mutual reinforcement between to use, can strengthen relieving constipation by purgation effect.Stagnation of pathogen inside the body, then internal organs gas is not
It is logical.During gas is wide under Cortex Magnoliae Officinalis, consumer product dredge stasis, dried immature fruit of citron orange relieving distension and oppression, can help rheum officinale, saltcake push away swing it is stagnant, to accelerate the excretion of thermojunction.
Rheum officinale, Cortex Magnoliae Officinalis, the dried immature fruit of citron orange, saltcake compatible use, for anxious lower agent, can control gastrointestinal retention, constipation with heat retention, abdomen expires distending pain.Separately there is chicken
Interior gold promoting digestion and removing indigestion, invigorating the spleen and stomach, demonstrate,proves various dyspepsias effective.Radish seed acrid flavour row dissipates, and function promoting digestion and removing indigestion, promoting the circulation of qi disappears
It is swollen.The pungent row temperature of dried orange peel is logical, there is the work(of promoting qi circulation and relieving pain, invigorating spleen.
Above-mentioned seven flavor medicine compatible use, have consumer product dredge stasis, drastic purgation thermojunction, relieving distension and oppression, stomach strengthening and digestion promoting, promoting qi circulation and relieving pain it
Effect, treatment donkey acute gastric dilatation are evident in efficacy.
Embodiment
The present invention is further described below by specific embodiment, following embodiments are descriptive, are not limits
Qualitatively, it is impossible to which protection scope of the present invention is limited with this.
Embodiment 1
A kind of Chinese medicinal aqua for treating donkey acute gastric dilatation, the parts by weight of each raw material are as follows：12 parts of rheum officinale, Cortex Magnoliae Officinalis 24
Part, 12 parts of the dried immature fruit of citron orange, 10 parts of saltcake, 18 parts of the membrane of a chicken's gizzard, 12 parts of radish seed, 12 parts of dried orange peel are prepared.Its preparation method is：(1)
Chinese medicine is crushed to 40 mesh, is weighed by formula ratio, three-dimensional hybrid obtains traditional Chinese medicine powder；(2) mixed traditional Chinese medicine powder is put into extraction
In tank, when adding 10 times of amount boilings 8 small；(3) dregs of a decoction are filtered to remove, gained filtrate indwelling is spare；(4) dregs of a decoction are put into again and carried
Take in tank, when adding 6 times of amount boilings 4 small；(5) dregs of a decoction are filtered to remove, gained liquid merges with first time extracting liq；(6)60℃
Extracting solution be concentrated under reduced pressure to original volume 20%, filtering and removing slag are filling, and every bottle of 100ml, obtains finished product.
Embodiment 2
A kind of Chinese medicinal aqua for treating donkey acute gastric dilatation, the parts by weight of each raw material are as follows：16 parts of rheum officinale, Cortex Magnoliae Officinalis 32
Part, 16 parts of the dried immature fruit of citron orange, 12 parts of saltcake, 10 parts of the membrane of a chicken's gizzard, 7 parts of radish seed, 7 parts of dried orange peel are prepared.Its preparation method is：(1) will
Chinese medicine is crushed to 40 mesh, is weighed by formula ratio, and three-dimensional hybrid obtains traditional Chinese medicine powder；(2) mixed traditional Chinese medicine powder is put into extractor
In, when adding 10 times of amount boilings 8 small；(3) dregs of a decoction are filtered to remove, gained filtrate indwelling is spare；(4) dregs of a decoction are put into extraction again
In tank, when adding 6 times of amount boilings 4 small；(5) dregs of a decoction are filtered to remove, gained liquid merges with first time extracting liq；(6) 60 DEG C subtract
Pressing concentrated extracting solution, filtering and removing slag are filling, and every bottle of 100ml, obtains finished product to original volume 20%.
Embodiment 3
A kind of Chinese medicinal aqua for treating donkey acute gastric dilatation, the parts by weight of each raw material are as follows：18 parts of rheum officinale, Cortex Magnoliae Officinalis 20
Part, 15 parts of the dried immature fruit of citron orange, 15 parts of saltcake, 12 parts of the membrane of a chicken's gizzard, 10 parts of radish seed, 10 parts of dried orange peel are prepared.Its preparation method is：(1)
Chinese medicine is crushed to 40 mesh, is weighed by formula ratio, three-dimensional hybrid obtains traditional Chinese medicine powder；(2) mixed traditional Chinese medicine powder is put into extraction
In tank, when adding 10 times of amount boilings 8 small；(3) dregs of a decoction are filtered to remove, gained filtrate indwelling is spare；(4) dregs of a decoction are put into again and carried
Take in tank, when adding 6 times of amount boilings 4 small；(5) dregs of a decoction are filtered to remove, gained liquid merges with first time extracting liq；(6)60℃
Extracting solution be concentrated under reduced pressure to original volume 20%, filtering and removing slag are filling, and every bottle of 100ml, obtains finished product.
Clinical test
Experiment 1
One first 5 years old jack ass burst acute abdominalgia of Jixian, tianjin Municipality farmer breed is gone to a doctor.Interrogation knows the donkey because of forced labour
Excessively, add at night in the previous day and feed fine fodder, morbidity in morning.It is sick to switch to quickly acutely and continuation abdominal pain just in intermittent abdominal pain,
Sick donkey suddenly rises, anxious sleeping, sleeping ground rolling, sometimes in sitting position of dog gesture.Pulse increases number, is short of breath, body temperature is done without bright change, oral cavity
It is dry, taste is smelly, intestines sound weaken, finally disappear.Start front, after elbow, stock inner side, neck side, the basal part of the ear and eye circumference the local perspiration such as enclose, and
Panhidrosis afterwards.Examination per rectum feels that stomach wall is in dough hardness.Stomach tube probe is inserted into, discharges a small amount of acid smell body and scattered paste shape
Chyme, abdominal pain and respiratory symptom are not relieved, and are diagnosed as donkey acute gastric dilatation immediately.Then obtained by the embodiment of the present invention 1
Chinese medicinal aqua treated, disposably gavage aqua 100ml, 2h future trouble donkey and discharge a large amount of stench excrement, sick donkey colic symptoms
Obvious to mitigate, breathing is steady, and the symptom that rises and retires terminates.Next day adds one.The sick donkey recovery from illness to the 3rd day, start normal activity, into
Food.
Experiment 1 the result shows that, use the Chinese medicinal aqua treatment donkey acute gastric dilatation obtained by the embodiment of the present invention 1 to work
Hurry up, curative effect it is good, satisfied therapeutic effect can be obtained.
Experiment 2
Donkey acute primary dilatation of the stomach 10 is collected in this experiment altogether.The cause of disease is analyzed, there are 5 sick donkey overfeeding stodgy
Concentrated feed, has 4 sick donkeys to feed easy air-blowing, the greenfeed of fermentation, have 1 sick donkey use as a servant again after great quantity of water drinking, and be all to raise
A few hours sudden onset after feeding, beginning excrement amount is few and dilute soft, finally stops.Intermittent abdominal pain is presented at sick donkey initial stage, after switch to
Continuation abdominal pain and acutely, rises and retires, suddenly gets impatient sleeping again and again, and left and right rolling, disturbance is uneasy, does not listen commander, pushes way by shoving or bumping, dog seat,
It also is difficult to control using antalgesic.Sick donkey appetite is given up absolutely, and conjunctiva flush, severe one is dark red, is short of breath, 20~50 times/min, arteries and veins
Fight and increase number up to 110~120 times/min, body temperature is without significant change.Visited and examined with stomach catheter, there are 4 sick donkeys to discharge a large amount of acid smell bodies,
Abdominal pain mitigates rapidly, and breathing is steady.There is 1 sick a large amount of smelly liquid of acid of donkey discharge, abdominal pain mitigates.It is another to there are 5 sick donkeys only to discharge less
Gas and the smelly chyme of acid are measured, abdominal pain and respiratory symptom are not relieved.Examination per rectum spleen substantially moves afterwards, can in left kidney front lower place
Gastric cecum is touched, nervous, smooth, flexible stomach wall is inflatable dilatation of the stomach；Have it is viscous hard feel or pinch powder sample for food stagnation stomach
Expansion.Visited with reference to stomach catheter and examine and be diagnosed as acute primary dilatation of the stomach with clinical symptoms, wherein 4 are inflatable dilatation of the stomach, 5
For food stagnation dilatation of the stomach, 1 is hydrops dilatation of the stomach.Then treated with the Chinese medicinal aqua obtained by the embodiment of the present invention 1.One
Secondary property gavages 100ml, and the same day non-defecation person adds one on next day.After this law, except 1 secondary other diseases of especially severe is dead
Die outer, remaining 9 sick donkeys are fully recovered, and cure rate is up to 90%.
Experiment 2 the result shows that, it is high using Chinese medicinal aqua of the present invention treatment donkey acute gastric dilatation cure rate, without any pain,
It is easy to operate, it is adapted to clinical promotion and application.
The above, is only the preferred embodiments of the present invention, be it is illustrative rather than limited, can be according to being limited
Scope includes several embodiments, therefore changing and modifications in the case where not departing from present general inventive concept, should belong to the present invention's
Within protection domain.
Claims (5)
- A kind of 1. Chinese medicine composition for treating donkey acute gastric dilatation, it is characterised in that：By the raw material preparation of following mass fraction Into：12-18 parts of rheum officinale, 20-32 parts of Cortex Magnoliae Officinalis, 12-16 parts of the dried immature fruit of citron orange, 10-15 parts of saltcake, 10-18 parts of the membrane of a chicken's gizzard, radish seed 7-12 Part, 7-12 parts of dried orange peel.
- A kind of 2. Chinese medicine composition for treating donkey acute gastric dilatation according to claim 1, it is characterised in that：Optimum feed stock Mass fraction it is as follows：12 parts of rheum officinale, 24 parts of Cortex Magnoliae Officinalis, 12 parts of the dried immature fruit of citron orange, 10 parts of saltcake, 18 parts of the membrane of a chicken's gizzard, 12 parts of radish seed, 12 parts of dried orange peel.
- 3. the Chinese medicine composition for the treatment of donkey acute gastric dilatation according to claim 1 or 2, it is characterised in that：The Chinese medicine group Compound is the various conventional extract oral medicine dosage forms for containing or not contain pharmaceutic adjuvant.
- 4. the Chinese medicine composition for the treatment of donkey acute gastric dilatation according to claim 3, it is characterised in that：The preparation can be with It is aqua.
- A kind of 5. method for the Chinese medicinal aqua for preparing treatment donkey acute gastric dilatation as claimed in claim 4, it is characterised in that system Preparation Method is：(1) Chinese medicine is crushed to 30-80 mesh, is weighed by formula ratio, three-dimensional hybrid obtains traditional Chinese medicine powder；(2) in will be mixed Medicinal powder is put into extractor, add 5-15 times measure boiling 2-12 it is small when；(3) dregs of a decoction are filtered to remove, gained filtrate indwelling is spare； (4) dregs of a decoction are put into extractor again, add 5-10 times measure boiling 2-10 it is small when；(5) be filtered to remove the dregs of a decoction, gained liquid with First time extracting liq merges；(6) for the 30-100 DEG C of extracting solution that is concentrated under reduced pressure to original volume 10%-50%, filtering and removing slag are filling, obtain Finished product.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116808110A (en) * | 2023-05-12 | 2023-09-29 | 泸州市中医医院(泸州市中西医结合医院、泸州市江阳区中医医院) | Intestine-moistening and bowel-relaxing formula and preparation method thereof |
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2016
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116808110A (en) * | 2023-05-12 | 2023-09-29 | 泸州市中医医院(泸州市中西医结合医院、泸州市江阳区中医医院) | Intestine-moistening and bowel-relaxing formula and preparation method thereof |
| CN116808110B (en) * | 2023-05-12 | 2024-04-16 | 泸州市中医医院(泸州市中西医结合医院、泸州市江阳区中医医院) | Intestine-moistening and bowel-relaxing formula and preparation method thereof |
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