CN107970381A - 一种化痰的宣木瓜茶及其制备方法和应用 - Google Patents
一种化痰的宣木瓜茶及其制备方法和应用 Download PDFInfo
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Abstract
本发明提供了一种化痰的宣木瓜茶，它由如下重量份数的原料药制备得到：宣木瓜8‑12份、淡竹叶10‑15份、荷叶10‑18份、蒲公英8‑12份、紫苏6‑10份、芦根8‑12份，提取方法包括水提醇沉，喷雾干燥，本发明具有良好的化痰作用，并能治疗小儿咳嗽变异性哮喘。
Description
技术领域
本发明涉及保健茶技术领域，具体涉及一种化痰的宣木瓜茶及其制备方法和应用。
背景技术
化痰常用药物如半夏、陈皮、茯苓、贝母等。痰证因病邪留阻部位.临床表现及病机的不同，化痰法常与宣肺.顺气.清热.燥湿.健脾.温阳或熄风潜阳等法分别配合应用。痰为津液所化。津液是人体正常生理性体液，痰是有形的一种病理产物。多因外感风寒湿热之盛，内伤七情饮食之郁，以致气逆液浊而成多量稀粘之汁。痰与饮常常互称，在临床上又有鉴别：粘而稠者为痰，清而稀者为饮。痰色黄者属于热证，色白者属于寒证。舌苔腻者多属湿痰，舌红口干者多为燥痰。因此研究开发化痰保健茶显得非常有意义。
宣木瓜含有十九种氨基酸、十八种矿物微量元素，以及大量维生素C，同时还含有皂甙、黄酮、苹果酸、齐墩果酸、枸橼酸、柠檬酸、酒石酸、抗坏血酸、反丁烯二酸、鞣质等，含有过氧化氢酶、酚氧化酶、氧化酶，特别富含超氧化物岐化酶(SOD)和齐墩果酸。其SOD的含量是世界上所有水果中无与伦比的，一克宣木瓜鲜果SOD的含量高达3227国际单位。SOD是现代美容养颜产品的核心物质，可以有效消除体内过剩自由基，增进肌体细胞更新。齐墩果酸具有广谱抗菌作用，具有护肝降酶、促免疫、抗炎、降血脂血糖等作用。
发明内容
发明目的：为了解决上述问题，本发明人在长期的临床试验中发现，本发明能化痰，对小儿咳嗽变异性哮喘有良好的作用。
技术方案：本发明的目的是通过如下的方案实现的：
一种化痰的宣木瓜茶，它由如下重量份数的原料药制备得到：宣木瓜8-12份、淡竹叶10-15份、荷叶10-18份、蒲公英8-12份、紫苏6-10份、芦根8-12份。
所述化痰的宣木瓜茶，它由如下重量份数的原料药制备得到：宣木瓜10份、淡竹叶12份、荷叶14份、蒲公英10份、紫苏8份、芦根10份。
所述化痰的宣木瓜茶，制备方法包括如下步骤：取以上原料药加水煎煮2次，每次加水量为药材重量的10倍量，每次煎煮2小时，合并煎液，浓缩至65℃时相对密度为1.10，加乙醇使含醇量的体积百分比达65％，搅拌，静置，过滤，滤液减压浓缩至65℃时相对密度为1.20并回收乙醇，得浓缩液，喷雾干燥，喷雾干燥条件为：进风温度为100，出风温度为80℃，物料温度为70℃，雾化压力为0.2兆帕，喷雾速度为10ml/s，粉碎成干浸膏粉，制粒，分装，即得宣木瓜茶。
所述化痰的宣木瓜茶在制备化痰保健品中的应用。
所述化痰的宣木瓜茶在制备治疗小儿咳嗽变异性哮喘保健品中的应用。
有益效果：本发明宣木瓜具有护肝降酶、促免疫、抗炎、降血脂血糖等作用，淡竹叶有清凉，解热、利尿及催产之效；主治：胸中疾热、咳逆上气、吐血、热毒风、止消渴、压丹石毒、消痰、治热狂烦闷、中风失音不语、痛头风、止惊悸、瘟疫迷闷、杀小虫、除热缓脾。荷叶清香升散具有清心解暑、散瘀止血、消风祛湿的功效。主治暑热烦渴，小儿惊痫，妇人血逆昏迷，跌伤呕血，月经不调，崩漏，湿疮疥癣。蒲公英清热解毒，利尿散结。治急性乳腺炎，淋巴腺炎，瘰疬，疔毒疮肿，急性结膜炎，感冒发热，急性扁桃体炎，急性支气管炎，胃炎，肝炎，胆囊炎，尿路感染。紫苏叶能散表寒，发汗力较强，用于风寒表症，见恶寒、发热、无汗等症，常配生姜同用；如表症兼有气滞，有可与香附、陈皮等同用。行气宽中紫苏叶用于脾胃气滞、胸闷、呕恶。芦根，别称芦茅根、苇根、芦头、芦柴根，生于江河湖泽、池塘沟渠沿岸和低湿地。也是中药名，用于热病烦渴、胃热呕吐、肺热咳嗽、肺痈吐脓、热淋涩痛。全方配伍，宣木瓜为君药，淡竹叶、荷叶、蒲公英、紫苏为臣药，芦根为佐使药，具有良好的化痰作用。
具体实施方式
以下通过实施例形式，对本发明的上述内容再作进一步的详细说明，但不应将此理解为本发明上述主题的范围仅限于以下的实例，凡基于本发明上述内容所实现的技术均属于本发明的范围。
实施例1：取宣木瓜8份、淡竹叶15份、荷叶10份、蒲公英12份、紫苏6份、芦根12份，制备方法包括如下步骤：取以上原料药加水煎煮2次，每次加水量为药材重量的10倍量，每次煎煮2小时，合并煎液，浓缩至65℃时相对密度为1.10，加乙醇使含醇量的体积百分比达65％，搅拌，静置，过滤，滤液减压浓缩至65℃时相对密度为1.20并回收乙醇，得浓缩液，喷雾干燥，喷雾干燥条件为：进风温度为100，出风温度为80℃，物料温度为70℃，雾化压力为0.2兆帕，喷雾速度为10ml/s，粉碎成干浸膏粉，制粒，分装，即得宣木瓜茶。
实施例2：取宣木瓜12份、淡竹叶10份、荷叶18份、蒲公英8份、紫苏10份、芦根8份，制备方法包括如下步骤：取以上原料药加水煎煮2次，每次加水量为药材重量的10倍量，每次煎煮2小时，合并煎液，浓缩至65℃时相对密度为1.10，加乙醇使含醇量的体积百分比达65％，搅拌，静置，过滤，滤液减压浓缩至65℃时相对密度为1.20并回收乙醇，得浓缩液，喷雾干燥，喷雾干燥条件为：进风温度为100，出风温度为80℃，物料温度为70℃，雾化压力为0.2兆帕，喷雾速度为10ml/s，粉碎成干浸膏粉，制粒，分装，即得宣木瓜茶。
实施例3：取宣木瓜10份、淡竹叶12份、荷叶14份、蒲公英10份、紫苏8份、芦根10份，制备方法包括如下步骤：取以上原料药加水煎煮2次，每次加水量为药材重量的10倍量，每次煎煮2小时，合并煎液，浓缩至65℃时相对密度为1.10，加乙醇使含醇量的体积百分比达65％，搅拌，静置，过滤，滤液减压浓缩至65℃时相对密度为1.20并回收乙醇，得浓缩液，喷雾干燥，喷雾干燥条件为：进风温度为100，出风温度为80℃，物料温度为70℃，雾化压力为0.2兆帕，喷雾速度为10ml/s，粉碎成干浸膏粉，制粒，分装，即得宣木瓜茶。
实施例4：本发明宣木瓜茶对化痰药效试验资料
动物：ICR小鼠，清洁级，雌雄各半，体重16-18g，由安徽医科大学实验动物中心提供。
保健品：按上述实施例3制备成宣木瓜茶，规格：5g生药/g、氯化铵(南京化学试剂厂，批号：20150608)。
对小鼠气管酚红排痰量的影响：
分组：小鼠随机分为5组：空白对照组(等容积生理盐水)，氯化铵组(1.0g/kg)、本发明宣木瓜茶高(20g/kg)、宣木瓜茶中(10g/kg)、宣木瓜茶低(5g/kg)三个剂量组。
实验方法：取小鼠50只随机分组，灌胃给药，于第5天给药后1h，腹腔注射5％酚红(0.1ml/10g体重)，30min后处死小鼠。剪下小鼠自甲状软骨至气管分支处的一段气管，放入盛有2ml生理盐水的试管中，振摇，再加入0.1ml1mol/LNaOH，用754分光光度仪(上海)在波长550nm条件下测OD值。根据酚红标准曲线查出每鼠的气管酚红排出量。
实验结果：本发明宣木瓜茶高、中剂量组均能明显增加小鼠气管酚红排出量，与对照组比较差异均有显著性(P<0.05或P<0.01)(见表1)。
表1.本发明宣木瓜茶对小鼠气管酚红排痰量的影响
注：与空白对照组比较*P<0.05；**P<0.01
结论实验结果表明本发明宣木瓜茶能有效增加小鼠气管粘液分泌，使酚红排出量明显增加。因此提示本发明宣木瓜茶具有化痰作用，对改善症状有一定的帮助。
实施例5：本发明宣木瓜茶治疗小儿咳嗽变异性哮喘临床研究
一般性资料：本发明宣木瓜茶应用于临床观察小儿咳嗽变异性哮喘病例100例，年龄1～9岁。病程最短者1个月，最长者达1年。
诊断标准：参照1998年全国儿童哮喘防治协作组制定的CVA诊断标准[1].(1)持续咳嗽或咳嗽反复发作＞1月，常在夜间或清晨发作性咳嗽，少痰，运动后、遇冷空气、嗅到特异气味后咳嗽加重。(2)无感染征象，经长时间抗生素治疗无效。(3)气管扩张剂诊断性治疗可使咳嗽缓解。(4)有个人过敏史和家族过敏史，过敏原检测阳性，气道呈高反应特征，支气管激发试验阳性可作为辅助诊断。
试验方法：按上述实施例3制备方法制备宣木瓜茶，规格为每袋10克，五天为一疗程，一天三袋，分早、中、晚三次饭前半小时服用。服药期间忌食生冷、辛辣、刺激及腐烂之物。空白组口服安慰剂颗粒剂，五天为一疗程，一天三袋，分早、中、晚三次饭前半小时服用。
疗效标准：参照《中医病证诊断疗效标准》：痊愈：治疗1～2个疗程，咳嗽，咯痰、流涕等症状消失，1年内症状未见反复；有效：经治疗2～3个疗程，咳嗽、咯痰、流涕明显好转，1年内症状有反复，重新加减治疗，症状完全消失，观察1年无反复。无效：3～4个疗程后临床症状仍无改善，甚至加重。
治疗效果：见表2。
表2两组疗效比较
| 组别 | n | 痊愈 | 有效 | 无效 | 总有效率(％) |
| 治疗组 | 50 | 20 | 26 | 4 | 92 |
| 空白组 | 50 | 2 | 1 | 27 | 6 |
可见，本发明制得的宣木瓜茶能够安全有效治疗小儿咳嗽变异性哮喘，且无毒副作用。
Claims (5)
1.一种化痰的宣木瓜茶，其特征在于，它由如下重量份数的原料药制备得到：宣木瓜8-12份、淡竹叶10-15份、荷叶10-18份、蒲公英8-12份、紫苏6-10份、芦根8-12份。
2.如权利要求1所述化痰的宣木瓜茶，其特征在于，它由如下重量份数的原料药制备得到：宣木瓜10份、淡竹叶12份、荷叶14份、蒲公英10份、紫苏8份、芦根10份。
3.根据权利要求1所述化痰的宣木瓜茶，其特征在于，制备方法包括如下步骤：取以上原料药加水煎煮2次，每次加水量为药材重量的10倍量，每次煎煮2小时，合并煎液，浓缩至65℃时相对密度为1.10，加乙醇使含醇量的体积百分比达65％，搅拌，静置，过滤，滤液减压浓缩至65℃时相对密度为1.20并回收乙醇，得浓缩液，喷雾干燥，喷雾干燥条件为：进风温度为100，出风温度为80℃，物料温度为70℃，雾化压力为0.2兆帕，喷雾速度为10ml/s，粉碎成干浸膏粉，制粒，分装，即得宣木瓜茶。
4.根据权利要求1所述化痰的宣木瓜茶在制备化痰保健品中的应用。
5.根据权利要求1所述化痰的宣木瓜茶在制备治疗小儿咳嗽变异性哮喘保健品中的应用。
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