CN107950929A - It is a kind of that there is composition for improving sleep function and its preparation method and application - Google Patents
It is a kind of that there is composition for improving sleep function and its preparation method and application Download PDFInfo
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- CN107950929A CN107950929A CN201610896774.6A CN201610896774A CN107950929A CN 107950929 A CN107950929 A CN 107950929A CN 201610896774 A CN201610896774 A CN 201610896774A CN 107950929 A CN107950929 A CN 107950929A
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of composition for having and improving sleep function, said composition is：Spina date seed, gamma aminobutyric acid, radix glycyrrhizae, jujube, wheat.The invention also discloses the preparation method and purposes of the composition.Each component reasonable recipe of the present invention, synergistic function is obvious, experiments prove that it has the function of to improve sleep etc., can be widely used for preparing food or health products；Each ingredient origin of the present composition is easy to get at the same time, and preparation method is simple, and technological process is simple, suitable for mass production.
Description
Technical field
The invention belongs to food or field of health care food, more particularly to a kind of composition with improvement sleep and its preparation
Method and purposes.
Background technology
Insomnia can bring different degrees of puzzlement, influence normal working and learning, and family and people
Border relation etc., insomnia typically refer to one kind that patient is unsatisfactory for the length of one's sleep and (or) quality and then influences social function on daytime
Subjective experience, including difficulty falling asleep, awakening often and (or) morning wakes up too early.Can cause the feeling of fatigue of people, uneasiness, general malaise,
Listless, delay of response, headache, memory do not collect medium symptom, in terms of its maximum effect is spirit, can be led when serious
Cause schizophrenia.
This sleep-disorder is treated, hypnotic is eaten in many people's selections.Although hypnotic curative effect is obvious, to the wound of body
Evil is also great, easily causes a series of adverse reaction：Drowsiness, tired, allergy (metamorphosis) is reacted, hematological system reacts,
Acute poisoning reaction, breathing or cardiovascular system reaction etc..The Chinese herbal medicine that China's Traditional Chinese Medicine uses, has medicinal and edible guarantor concurrently
It is good in one, and medicine source is extensive, has no toxic side effect.Therefore, developing a kind of medicinal or edible or edible health level improves sleep
Composition is very necessary.
The content of the invention
Based on above present situation, object of the present invention is to provide a kind of composition for having and improving sleep function, for a long time
Sleep-disorder can effectively be reduced, extend the length of one's sleep, improve sleep quality by taking said composition, can make one tranquilization and refreshment, energy
Plentifully.
Concrete technical scheme of the present invention is that the composition is made of following weight：0.5-10 parts of spina date seed,
0.2-2 parts of γ-aminobutyric acid, 0.5-10 parts of radix glycyrrhizae, 0.5-10 parts of jujube, 0.5-10 parts of wheat.
Further, the composition is made of following weight：1-8 parts of spina date seed, γ-aminobutyric acid 0.2-1.5
Part, 1-8 parts of radix glycyrrhizae, 1-7 parts of jujube, 1-8 parts of wheat.
Further, the composition is made of following weight：3-6 parts of spina date seed, 0.3-1 parts of γ-aminobutyric acid,
2-5 parts of radix glycyrrhizae, 2-5 parts of jujube, 1.5-6 parts of wheat.
Above-mentioned composition ingredient origin is as follows：
Spina date seed：(Ziziphus jujuba Mill.var.spinosa), alias jujube kernel, jujube nucleus, mountain jujube benevolence.Its property
It is flat, sweet in flavor, the heart channel of Hang-Shaoyin, Liver Channel can be entered, there is mental-tranquilization, the cloudy arrest sweating of benefit, suitable for treatment restlessness of asrhenia type and insomnia, palpitation with fear palpitation,
Polydipsia, night sweat.
γ-aminobutyric acid：The inhibitory transmitter of central nervous system, be in brain tissue most important neurotransmitter it
One, it can reduce neuronal activity, suppress anxiety information and be passed to mesencephalic centre, calm nerve and antianxiety, have stable spirit, calm
Effect, can improve the symptoms such as nerve gastrointestinal dysfunction, sleep-disorder, self-disciplining nervous disorder.
Radix glycyrrhizae：(Glycyrrhiza uralensis Fisch) alias：State is old, Herba Hedyotis cantonensis, Glycyrrhiza Uralensis, sweet tea root.Beans
Section, Glycyrrhiza perennial herb, medicinal part are root and rhizomes, sweet and neutral.Enter spleen, stomach, lung channel.Stop with invigorating middle warmer and replenishing QI, emergency
Bitterly, moisten the lung and relieve the cough, purging intense heat and detonicating, coordinating the drug actions of a prescription the effect of, available for weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, phlegm of coughing
It is more, gastral cavity abdomen, four limbs contraction, big loose stool are thin, weak, fever, dysphoria insomnia, carbuncle sore tumefacting virus, alleviate drug toxicity, strong.
Modern pharmacology experimental study shows：Glycyrrhizin in radix glycyrrhizae can improve serum lipids, have sedation effect and lost so as to reach alleviation
The effect of sleeping and improving sleep quality.
Jujube：(Ziziphus zizyphus) also known as jujube, dry jujube, Chinese date, originating from China, in China existing 8,000
Plantation history for many years, is just listed in one of " five fruits " (chestnut, peach, Lee, apricot, jujube) since ancient times.Warm-natured, returns spleen stomach sweet in flavor,
There are tonifying middle-Jiao and Qi, nourishing blood and tranquilization, the function of relaxing pharmacological property, modern pharmacology is found, contained flavones-bis--grape in jujube
Glucoside A has calm, hypnosis and antihypertensive effect, wherein the naringenin C glucosides being separated have central inhibitory action, that is, reduces certainly
Shipping is dynamic and stimulates reflex, tetanic numb effect, therefore jujube has the effect of calming the nerves, calm.
Wheat：(TriticumaestivumLinn) belong to the general designation of wheat system plant, be a kind of extensive all over the world
The grass of plantation, originating from Middle East crescent fertile soil area.It has promote the production of body fluid hidroschesis, relieving mental strain and strengthening the kidney, the quiet QI invigorating of kidney, invigorating the spleen
The effect of thick intestines, heat extraction quench the thirst, suitable for body void hidrosis, the dry dry of tongue, vexed insomnia disease, can reach ataraxy and promote body
The effect of power.
Therefore, inventive formulation component spina date seed, radix glycyrrhizae, three medicine compatibility of jujube have mental-tranquilization, and the work(of middle emergency
Effect, at the same compatibility wheat and modern medicine study by reducing neuronal activity, suppress anxiety information be passed to the γ of mesencephalic centre-
Aminobutyric acid, so as to reach calm nerve, relieving insomnia, improve the effect of sleep quality.
According to a preferred embodiment of the invention, the composition is tablet, pill, granule, pulvis, oral liquid
Any one in body agent.
According to a preferred embodiment of the invention, the composition is through the following steps that be prepared：
The raw material of the parts by weight is directly ground to coarse powder；Or adding the extraction of the ethanol of water or various concentrations, extracting solution is dense
Contract dry crude extract；Or further steamed using water extraction and alcohol precipitation method, centrifugal process, organic solvent extractionprocess, column chromatography, vapor
The method of evaporating carries out being refining to obtain extract；Above-mentioned medicinal material coarse powder or crude extract or extract are not added with or add appropriate amount of auxiliary materials and phase is made
Answer formulation.
It is different according to its carrier of different preparations or auxiliary material, such as in tablet, capsule, granule solid pharmaceutical preparation
Common diluent, disintegrant, excipient, adhesive, lubricant, surfactant, filler etc.；In syrup, oral liquid etc.
Common surfactant, diluent, preservative, stabilizer, flavouring, thickener etc. in liquid forms.
Its common auxiliary material such as starch, lactose, sucrose, dextrin, Icing Sugar, microcrystalline cellulose, mannitol, xylitol, poly- second two
Alcohol, calcium sulfate, calcium monohydrogen phosphate, calcium carbonate, modified starch, sorbierite, antierythrite, polyvinylpyrrolidone, heavy magnesium carbonate,
Sodium carboxymethylcellulose, hypromellose, methylcellulose, ethyl cellulose, carboxyrnethyl starch sodium, hydroxypropyl cellulose,
PVP K30, white bole, pregelatinized starch, magnesium stearate, talcum powder, superfine silica gel powder, silica, stevioside glycosides, beet
Alkali, aspartame, glycyrrhizin, saccharin sodium, rock sugar, honey, Sucralose, xylitol, citric acid, sodium acid carbonate, sodium carbonate,
Carragheen, agar, gelatin, sodium alginate, xanthans, guar gum, tragcanth, Arabic gum, locust bean gum, stearic acid, list
Tristerin, polyacrylamide, cross linked sodium polyacrylate, polyvinyl alcohol, carbomer, sorbic acid, potassium sorbate, oxybenzene
Ethyl ester, phenmethylol, nipalgin, thimerosal, dimethyl sulfoxide (DMSO), azone, triethanolamine, sodium hydroxide, glycerine, propane diols, BHT,
BHA, lauryl sodium sulfate, Tweens, spans etc..
Further, the composition is through the following steps that be prepared：
1) spina date seed and wheat are smashed to pieces；Jujube is splitted, and is then weighed spina date seed, radix glycyrrhizae, jujube by weight ratio, is added
9-12 times is measured water, extracts 1-3h, is filtered, and filtrate is spare；Filter residue merges with wheat plus 6-9 times is measured water extraction 1-3h, filters, two
Secondary filtrate merges；
2) filtrate is concentrated under reduced pressure, centrifuges, filters, is concentrated under reduced pressure into thick paste, add filler and glidant, be decompressed to
Dry cream, adds γ-aminobutyric acid, the flavouring of formula ratio, mixes, granulation, up to granule.
Further, the filler is one kind in dextrin, starch, mannitol, maltodextrin, lactose, microcrystalline cellulose
It is or several；Glidant is magnesium stearate, talcum powder, superfine silica gel powder, silica are one or more of；The flavouring STEVIA REBAUDIANA
Glycosides, glycine betaine, aspartame, glycyrrhizin, saccharin sodium, xylitol, rock sugar, honey, Sucralose, sucrose, citric acid, winestone
Acid, glycine betaine are one or more of.
Another purpose provided by the invention is the method for preparing compositions as described above, and the described method includes following step
Suddenly：
The raw material of the parts by weight is directly ground to coarse powder；Or adding the extraction of the ethanol of water or various concentrations, extracting solution is dense
Contract dry crude extract；Or further steamed using water extraction and alcohol precipitation method, centrifugal process, organic solvent extractionprocess, column chromatography, vapor
The method of evaporating carries out being refining to obtain extract；Above-mentioned medicinal material coarse powder or crude extract or extract are not added with or add appropriate amount of auxiliary materials and phase is made
Answer formulation.
It is different according to its carrier of different preparations or auxiliary material, such as in tablet, capsule, granule solid pharmaceutical preparation often
Diluent, disintegrant, excipient, adhesive, lubricant, surfactant, filler etc.；In liquid such as syrup, oral liquids
Common surfactant, diluent, preservative, stabilizer, flavouring, thickener etc. in body preparation form.
Its common auxiliary material such as starch, lactose, sucrose, dextrin, Icing Sugar, microcrystalline cellulose, mannitol, xylitol, poly- second two
Alcohol, calcium sulfate, calcium monohydrogen phosphate, calcium carbonate, modified starch, sorbierite, antierythrite, polyvinylpyrrolidone, heavy magnesium carbonate,
Sodium carboxymethylcellulose, hypromellose, methylcellulose, ethyl cellulose, carboxyrnethyl starch sodium, hydroxypropyl cellulose,
PVP K30, white bole, pregelatinized starch, magnesium stearate, talcum powder, superfine silica gel powder, silica, stevioside glycosides, beet
Alkali, aspartame, glycyrrhizin, saccharin sodium, rock sugar, honey, Sucralose, xylitol, citric acid, sodium acid carbonate, sodium carbonate,
Carragheen, agar, gelatin, sodium alginate, xanthans, guar gum, tragcanth, Arabic gum, locust bean gum, stearic acid, list
Tristerin, polyacrylamide, cross linked sodium polyacrylate, polyvinyl alcohol, carbomer, sorbic acid, potassium sorbate, oxybenzene
Ethyl ester, phenmethylol, nipalgin, thimerosal, dimethyl sulfoxide (DMSO), azone, triethanolamine, sodium hydroxide, glycerine, propane diols, BHT,
BHA, lauryl sodium sulfate, Tweens, spans etc..
Further, the described method comprises the following steps：
1) spina date seed and wheat are smashed to pieces；Jujube is splitted, and is then weighed spina date seed, radix glycyrrhizae, jujube by weight ratio, is added
9-12 times is measured water, extracts 1-3h, is filtered, and filtrate is spare；Filter residue merges with wheat plus 6-9 times is measured water extraction 1-3h, filters, two
Secondary filtrate merges；
2) filtrate is concentrated under reduced pressure, centrifuges, filters, is concentrated under reduced pressure into thick paste, add filler and glidant, be decompressed to
Dry cream, adds γ-aminobutyric acid, the flavouring of formula ratio, mixes, granulation, up to granule.
Further, the filler is one kind in dextrin, starch, mannitol, maltodextrin, lactose, microcrystalline cellulose
It is or several；Glidant is magnesium stearate, talcum powder, superfine silica gel powder, silica are one or more of；The flavouring STEVIA REBAUDIANA
Glycosides, glycine betaine, aspartame, glycyrrhizin, xylitol, saccharin sodium, rock sugar, honey, Sucralose, sucrose, citric acid, winestone
Acid, glycine betaine are one or more of.
Another purpose provided by the invention is to provide compositions as described above or the composition prepared by the method
Purposes, the composition be used to prepare relieving insomnia, improve sleep food or health products in purposes.
Beneficial effects of the present invention
Each component of composition disclosed in this invention is that inventor progressively sieves according to traditional Chinese medical theory basis with the mechanism of action
Choosing, optimum organization, verify and obtain repeatedly, has significant synergistic function between each component, for relieving insomnia, improves and sleeps
Dormancy has effects that fine, while each ingredient origin is easy to get, and it is simple to prepare composition process, suitable for mass production.
Embodiment
The foregoing invention content of the present invention is described in further detail with reference to embodiment.
But the scope that this should not be interpreted as to the above-mentioned theme of the present invention is only limitted to following embodiments.On the present invention is not departed from
In the case of stating technological thought, according to ordinary skill knowledge and customary means, various replacements and change are made, should all be included
Within the scope of the invention.
5 parts of 1 spina date seed of embodiment, 0.4 part of γ-aminobutyric acid, 3 parts of radix glycyrrhizae, 3 parts of jujube, 2 parts of wheat
Spina date seed and wheat are smashed to pieces；Jujube is splitted, and is then weighed spina date seed, radix glycyrrhizae, jujube by weight ratio, is added 9
Amount water again, extracts 3h, filters, and filtrate is spare；Filter residue merges with wheat plus 6 times of amount water extraction 1h, filtering, and filtrate merges twice；
Filtrate is concentrated under reduced pressure, centrifuge, take supernatant to continue to be concentrated under reduced pressure into clear cream, add formula ratio γ-aminobutyric acid and
Appropriate amount of auxiliary materials maltodextrin, xylitol, silica, Sucralose etc., dry, pulverize into fine powder, and pulvis is made.
2 parts of 2 spina date seed of embodiment, 0.25 part of γ-aminobutyric acid, 6 parts of radix glycyrrhizae, 1.5 parts of jujube, 7 parts of wheat
Spina date seed and wheat are smashed to pieces；Jujube is splitted, and then weighs spina date seed, radix glycyrrhizae, jujube by weight ratio, adds 10 times
Water is measured, extracts 2h, is filtered, filtrate is spare；Filter residue merges with wheat plus 6 times of amount water extraction 1h, filtering, and filtrate merges twice；Will
Filtrate is concentrated under reduced pressure, and centrifugation, takes supernatant to continue to be concentrated under reduced pressure into clear cream, adds the γ-aminobutyric acid of formula ratio and fits
Amount auxiliary material maltodextrin, xylitol, silica, Sucralose etc., dry, pulverize into fine powder, and pulvis is made.
4 parts of 3 spina date seed of embodiment, 0.8 part of γ-aminobutyric acid, 3 parts of radix glycyrrhizae, 4 parts of jujube, 5 parts of wheat
Spina date seed and wheat are smashed to pieces；Jujube is splitted, and then weighs spina date seed, radix glycyrrhizae, jujube by weight ratio, adds 11 times
Water is measured, extracts 2h, is filtered, filtrate is spare；Filter residue merges with wheat plus 7 times of amount water extraction 1h, filtering, and filtrate merges twice；Will
Filtrate is concentrated under reduced pressure, and centrifugation, takes supernatant to continue to be concentrated under reduced pressure into clear cream, add the γ-aminobutyric acid of formula ratio, does
It is dry, fine powder is ground into, is mixed with appropriate lactose, is pelletized, dry, whole grain, adds appropriate magnesium stearate, mixes, tabletting, coating,
To obtain the final product.
0.8 part of 4 spina date seed of embodiment, 1.7 parts of γ-aminobutyric acid, 0.8 part of radix glycyrrhizae, 8 parts of jujube, 9 parts of wheat
Spina date seed and wheat are smashed to pieces；Jujube is splitted, and then weighs spina date seed, radix glycyrrhizae, jujube by weight ratio, adds 12 times
Water is measured, extracts 3h, is filtered, filtrate is spare；Filter residue merges with wheat plus 8 times of amount water extraction 1h, filtering, and filtrate merges twice；Will
Filtrate is concentrated under reduced pressure, and centrifugation, takes supernatant to continue to be concentrated under reduced pressure into clear cream, add the γ-aminobutyric acid of formula ratio, does
It is dry, fine powder is ground into, is mixed with appropriate lactose, is pelletized, dry, whole grain, adds appropriate magnesium stearate, mixes, tabletting, coating,
To obtain the final product.
0.5 part of 5 spina date seed of embodiment, 0.1 part of γ-aminobutyric acid, 10 parts of radix glycyrrhizae, 10 parts of jujube, 0.5 part of wheat
Spina date seed and wheat are smashed to pieces；Jujube is splitted, and then weighs spina date seed, radix glycyrrhizae, jujube by weight ratio, adds 12 times
Water is measured, extracts 2h, is filtered, filtrate is spare；Filter residue merges with wheat plus 7 times of amount water extraction 1h, filtering, and filtrate merges twice；Will
Filtrate is concentrated under reduced pressure, and centrifugation, takes supernatant to continue to be concentrated under reduced pressure into clear cream, add the γ-aminobutyric acid of formula ratio, does
It is dry, fine powder is ground into, adds appropriate amount of auxiliary materials, mixes, pill is made.
3 parts of 6 spina date seed of embodiment, 0.3 part of γ-aminobutyric acid, 5 parts of radix glycyrrhizae, 2 parts of jujube, 6 parts of wheat
Spina date seed and wheat are smashed to pieces；Jujube is splitted, and then weighs spina date seed, radix glycyrrhizae, jujube by weight ratio, adds 10 times
Water is measured, extracts 1.5h, is filtered, filtrate is spare；Filter residue merges with wheat plus 8 times of amount water extraction 1h, filtering, and filtrate merges twice；
Filtrate is concentrated under reduced pressure, add formula ratio γ-aminobutyric acid and appropriate amount of auxiliary materials maltodextrin, xylitol, silica,
Sucralose etc., dry, pulverize into fine powder, and pulvis is made.
1 part of 7 spina date seed of embodiment, 0.2 part of γ-aminobutyric acid, 1 part of radix glycyrrhizae, 7 parts of jujube, 8 parts of wheat
Spina date seed and wheat are smashed to pieces；Jujube is splitted, and then weighs spina date seed, radix glycyrrhizae, jujube by weight ratio, adds 11 times
Water is measured, extracts 1.5h, is filtered, filtrate is spare；Filter residue merges with wheat plus 7 times of amount water extraction 1h, filtering, and filtrate merges twice；
Filtrate is concentrated under reduced pressure, the γ-aminobutyric acid and appropriate amount of auxiliary materials of formula ratio is added, dry, pulverize into fine powder, be made packed
Medicinal tea, bag tea agent.
6 parts of 8 spina date seed of embodiment, 1 part of γ-aminobutyric acid, 2 parts of radix glycyrrhizae, 5 parts of jujube, 1.5 parts of wheat
Spina date seed and wheat are smashed to pieces；Jujube is splitted, and then weighs spina date seed, radix glycyrrhizae, jujube by weight ratio, adds 11 times
Water is measured, extracts 1.5h, is filtered, filtrate is spare；Filter residue merges with wheat plus 7 times of amount water extraction 1h, filtering, and filtrate merges twice；
Filtrate is concentrated under reduced pressure, the γ-aminobutyric acid and appropriate amount of auxiliary materials for adding formula ratio dry, pulverize into fine powder, be made packed
Medicinal tea, bag tea agent.
8 parts of 9 spina date seed of embodiment, 1.5 parts of γ-aminobutyric acid, 8 parts of radix glycyrrhizae, 1 part of jujube, 1 part of wheat
Spina date seed and wheat are smashed to pieces；Jujube is splitted, and then weighs spina date seed, radix glycyrrhizae, jujube by weight ratio, adds 10 times
Water is measured, extracts 1.5h, is filtered, filtrate is spare；Filter residue merges with wheat plus 8 times of amount water extraction 1h, filtering, and filtrate merges twice；
Filtrate is concentrated under reduced pressure, appropriate amount of auxiliary materials, dry, pulverize into fine powder, and packed medicinal tea, bag tea agent is made.
10 parts of 10 spina date seed of embodiment, 2 parts of γ-aminobutyric acid, 0.5 part of radix glycyrrhizae, 0.5 part of jujube, 10 parts of wheat
Wheat is smashed to pieces；Jujube is splitted, and then weighs radix glycyrrhizae, jujube by weight ratio, is added 10 times of amount water, is extracted 1.5h,
Filtering, filtrate are spare；Filter residue merges with wheat plus 8 times of amount water extraction 1h, filtering, and filtrate merges twice；Filtrate is depressurized
Concentration, appropriate amount of auxiliary materials, dry, pulverize into fine powder, and packed medicinal tea, bag tea agent is made.
0.25 part of 11 γ-aminobutyric acid of comparative example, 6 parts of radix glycyrrhizae, 1.5 parts of jujube, 7 parts of wheat
Spina date seed and wheat are smashed to pieces；Jujube is splitted, and is then weighed spina date seed, radix glycyrrhizae, jujube by weight ratio, is added 9
Amount water again, extracts 3h, filters, and filtrate is spare；Filter residue merges with wheat plus 6 times of amount water extraction 1h, filtering, and filtrate merges twice；
Filtrate is concentrated under reduced pressure, centrifuge, take supernatant to continue to be concentrated under reduced pressure into clear cream, add formula ratio γ-aminobutyric acid and
Appropriate amount of auxiliary materials maltodextrin, xylitol, silica, Sucralose etc., dry, pulverize into fine powder, and pulvis is made.
2 parts of 12 spina date seed of comparative example, 6 parts of radix glycyrrhizae, 1.5 parts of jujube, 7 parts of wheat
Spina date seed and wheat are smashed to pieces；Jujube is splitted, and is then weighed spina date seed, radix glycyrrhizae, jujube by weight ratio, is added 9
Amount water again, extracts 3h, filters, and filtrate is spare；Filter residue merges with wheat plus 6 times of amount water extraction 1h, filtering, and filtrate merges twice；
Filtrate is concentrated under reduced pressure, centrifuge, take supernatant to continue to be concentrated under reduced pressure into clear cream, add formula ratio γ-aminobutyric acid and
Appropriate amount of auxiliary materials maltodextrin, xylitol, silica, Sucralose etc., dry, pulverize into fine powder, and pulvis is made.
Pass through the beneficial effect of following experiment the present invention is further explained the composition：
1st, MATERIALS METHODS
Animal：Kunming kind health cleaning grade mouse, 20 ± 2g of weight.
Test group 1：It is prepared by the embodiment of the present invention 1, the concentration needed for distilled water is made into is for experiment；
Test group 2：It is prepared by the embodiment of the present invention 2, the concentration needed for distilled water is made into is for experiment；
Test group 3：It is prepared by the embodiment of the present invention 3, the concentration needed for distilled water is made into is for experiment；
Control group 1：It is prepared by the embodiment of the present invention 11, the concentration needed for distilled water is made into is for experiment；
Control group 2：It is prepared by the embodiment of the present invention 12, the concentration needed for distilled water is made into is for experiment；
Blank control group：Distilled water.
2nd, test method
2.1 extend the experiment of the yellow Jackets length of one's sleep
Take normal mouse 60 to be only randomly divided into 6 groups, i.e. 3 test groups (test group 1, test group 2, test group 3), 2 it is right
According to group (control group 1, control group 2), 1 blank control group, tests and is carried out in night.The gavage amount of test group is prepared with distilled water
The embodiment 1-3 present compositions, the embodiment 11-12 compositions that the negative gavage amount of control group is prepared with distilled water are empty
White control group fills the distilled water of equivalent.Tested material 35 days are continuously given, last is to 30min after animal subject through penta bar of ratio of intraperitoneal injection
Appropriate sodium 30mg/kg BW, are judged to enter sleep, can observation tested material extend amobarbital with the righting reflex loss 60s of animal
The sodium length of one's sleep.
2.2 yellow Jackets sub-threshold dose hypnosis are tested
Take normal mouse 60 to be only randomly divided into 6 groups by weight, i.e. 3 test groups (test group 1, test group 2, test group 3),
2 control groups (control group 1, control group 2), 1 blank control group, test and are carried out in night.The gavage amount distillation of test group
The present composition that water is prepared, negative control group fill the distilled water of equivalent.Tested material 30 days are continuously given, after last is to tested material
30min is judged to enter sleep with the righting reflex loss 60s of animal, calculated through yellow Jackets 15mg/kg BW are injected intraperitoneally
Incidence of sleep animals.
3rd, experimental result
3.1 extend the experiment of the yellow Jackets length of one's sleep：It is shown in Table 1.
The influence that 1 tested material of table directly sleeps mouse
* represent there is significant (P with blank control group comparing difference<0.05)
* represents there is pole significant (P with blank control group comparing difference<0.01)
As seen from Table 1, the length of one's sleep of each test group mouse than blank control group extend, and with the difference of blank control group
It is different to be respectively provided with pole significant (P ＜ 0.01), show that the present composition has and significantly extend the yellow Jackets length of one's sleep
Effect；Control group 1, the length of one's sleep of 2 mouse extend than blank control group, and are respectively provided with the difference of blank control group aobvious
Work property meaning (P ＜ 0.01), shows that control group 1,2 compositions have the function that to extend the yellow Jackets length of one's sleep, but imitates
Fruit is not as good as the present composition.
3.2 yellow Jackets sub-threshold dose hypnosis are tested：It is shown in Table 2.
Influence of 2 tested material of table to mouse sleep incidence
* represent there is significant (P with blank control group comparing difference<0.05)
* represents there is pole significant (P with blank control group comparing difference<0.01)
As seen from Table 2, the incidence of sleep animals of each test group is higher than blank control group, and with the difference of blank control group
Pole significant (P ＜ 0.01) is respectively provided with, shows that the present composition has promotion hypnosis to the yellow Jackets of sub-threshold dose
Effect；The incidence of sleep animals of control group 1,2 is higher than blank control group, less than test group, and with the difference of blank control group
It is different to be respectively provided with significant (P ＜ 0.05), show that control group composition has promotion hypnosis to the yellow Jackets of sub-threshold dose
Effect, but effect is not as good as the present composition.
4-10 of the embodiment of the present invention has carried out similar experiment according to the method described above, as a result identical with the above results.
4th, conclusion
1) after the intragastric administration on mice present composition, compared with blank control group, when can significantly extend yellow Jackets sleep
Between, and play the role of promoting hypnosis to the yellow Jackets of sub-threshold dose, and difference has pole significant (P ＜ 0.01),
The prompting present composition has the function of to improve sleep.
2) the intragastric administration on mice present composition is compared with control group 1,2, extend the yellow Jackets length of one's sleep and, and
The yellow Jackets hypnosis facilitation of sub-threshold dose is become apparent from, prompts to have well between each component of the present composition
Synergistic function.
Claims (10)
1. a kind of have the composition for improving sleep function, it is characterised in that the composition is made of following weight：
0.5-10 parts of spina date seed, 0.1-2 parts of γ-aminobutyric acid, 0.5-10 parts of radix glycyrrhizae, 0.5-10 parts of jujube, 0.5-10 parts of wheat.
2. composition according to claim 1, it is characterised in that the composition is made of following weight：Acid
1-8 parts of jujube kernel, 0.2-1.5 parts of γ-aminobutyric acid, 1-8 parts of radix glycyrrhizae, 1-7 parts of jujube, 1-8 parts of wheat.
3. composition according to claim 2, it is characterised in that the composition is made of following weight：Acid
3-6 parts of jujube kernel, 0.3-1 parts of γ-aminobutyric acid, 2-5 parts of radix glycyrrhizae, 2-5 parts of jujube, 1.5-6 parts of wheat.
4. composition according to claim 1, it is characterised in that the composition is oral formulations, is rendered as pulvis, piece
Agent, capsule, pill, oral liquid, packed medicinal tea, bag tea agent any one form.
5. composition according to claim 1, it is characterised in that the composition is through the following steps that be prepared：
The raw material of the parts by weight is directly ground to coarse powder；Or adding the extraction of the ethanol of water or various concentrations, extracting solution is concentrated and dried
Crude extract；Or further carried out using water extraction and alcohol precipitation method, centrifugal process, organic solvent extractionprocess, column chromatography, steam distillation
It is refining to obtain extract；Above-mentioned medicinal material coarse powder or crude extract or extract are not added with or add appropriate amount of auxiliary materials and corresponding formulation is made.
6. composition according to claim 5, it is characterised in that the composition is through the following steps that be prepared：
1) spina date seed and wheat are smashed to pieces；Jujube is splitted, and is then weighed spina date seed, radix glycyrrhizae, jujube by weight ratio, is added 9-12
Amount water again, extracts 1-3h, filters, and filtrate is spare；Filter residue merges with wheat plus 6-9 times is measured water extraction 1-3h, and filtering, is filtered twice
Liquid merges；
2) filtrate is concentrated under reduced pressure, centrifuges, filters, is concentrated under reduced pressure into thick paste, add filler and glidant, be decompressed to dry
Cream, adds γ-aminobutyric acid, the flavouring of formula ratio, mixes, granulation, up to granule.
7. composition according to claim 6, it is characterised in that the filler is dextrin, starch, mannitol, malt
One or more in dextrin, lactose, microcrystalline cellulose；Glidant is magnesium stearate, talcum powder, superfine silica gel powder, silica
It is one or more of；The flavouring stevioside glycosides, glycine betaine, aspartame, glycyrrhizin, saccharin sodium, xylitol, rock sugar, bee
Honey, Sucralose, sucrose, citric acid, tartaric acid, glycine betaine are one or more of.
A kind of 8. method for preparing composition described in claim 1, it is characterised in that the described method comprises the following steps：By institute
The raw material for stating parts by weight is directly ground to coarse powder；Or adding the extraction of the ethanol of water or various concentrations, extracting solution is concentrated and dried slightly to carry
Thing；
Or essence is further carried out using water extraction and alcohol precipitation method, centrifugal process, organic solvent extractionprocess, column chromatography, steam distillation
Extract is made；Above-mentioned medicinal material coarse powder or crude extract or extract are not added with or add appropriate amount of auxiliary materials and corresponding formulation is made.
9. according to the method described in claim 8, it is characterized in that, it the described method comprises the following steps：
1) spina date seed and wheat are smashed to pieces；Jujube is splitted, and is then weighed spina date seed, radix glycyrrhizae, jujube by weight ratio, is added 9-12
Amount water again, extracts 1-3h, filters, and filtrate is spare；Filter residue merges with wheat plus 6-9 times is measured water extraction 1-3h, and filtering, is filtered twice
Liquid merges；
2) filtrate is concentrated under reduced pressure, centrifuges, filters, is concentrated under reduced pressure into thick paste, add filler and glidant, be decompressed to dry
Cream, adds γ-aminobutyric acid, the flavouring of formula ratio, mixes, granulation, up to granule.
10. the combination prepared according to any one of claim 1-7 any one of them composition or claim 8-9 the method
The purposes of thing, it is characterised in that the composition is used to prepare the purposes in the food or health products that improve sleep.
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| CN201610896774.6A CN107950929A (en) | 2016-10-14 | 2016-10-14 | It is a kind of that there is composition for improving sleep function and its preparation method and application |
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| CN201610896774.6A CN107950929A (en) | 2016-10-14 | 2016-10-14 | It is a kind of that there is composition for improving sleep function and its preparation method and application |
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Cited By (5)
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| CN110584035A (en) * | 2019-09-29 | 2019-12-20 | 厦门市养真保健食品有限公司 | Compound spina date seed and dark plum particle and preparation method thereof |
| CN112022847A (en) * | 2020-09-04 | 2020-12-04 | 华熙生物科技股份有限公司 | Composition capable of improving immunity and improving sleep and preparation method and application thereof |
| CN114027508A (en) * | 2021-12-03 | 2022-02-11 | 龙岩学院 | Functional food gamma-aminobutyric acid compound preparation for improving sleep |
| CN114304603A (en) * | 2020-09-29 | 2022-04-12 | 拜尔普兰（厦门）生物药业有限公司 | Sublingual instant granules of spina date seeds and preparation method thereof |
| CN114946986A (en) * | 2022-06-13 | 2022-08-30 | 广东一方制药有限公司 | Wild jujube soft sweets and preparation method thereof |
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| CN1531951A (en) * | 2003-03-21 | 2004-09-29 | 贵阳新天药业股份有限公司 | Chinese medicine compound preparation for nourishing the heart to calm the mind and preparing method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110584035A (en) * | 2019-09-29 | 2019-12-20 | 厦门市养真保健食品有限公司 | Compound spina date seed and dark plum particle and preparation method thereof |
| CN112022847A (en) * | 2020-09-04 | 2020-12-04 | 华熙生物科技股份有限公司 | Composition capable of improving immunity and improving sleep and preparation method and application thereof |
| CN114304603A (en) * | 2020-09-29 | 2022-04-12 | 拜尔普兰（厦门）生物药业有限公司 | Sublingual instant granules of spina date seeds and preparation method thereof |
| CN114027508A (en) * | 2021-12-03 | 2022-02-11 | 龙岩学院 | Functional food gamma-aminobutyric acid compound preparation for improving sleep |
| CN114946986A (en) * | 2022-06-13 | 2022-08-30 | 广东一方制药有限公司 | Wild jujube soft sweets and preparation method thereof |
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