CN107913301A - A kind of Essence of the Chinese medicine composition conserved for women privates and its extract containing said composition - Google Patents
A kind of Essence of the Chinese medicine composition conserved for women privates and its extract containing said composition Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/234—Cnidium (snowparsley)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/285—Aucklandia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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Abstract
This application discloses a kind of Chinese medicine composition for the maintenance of women privates, the Chinese medicine composition includes bulk pharmaceutical chemicals frutus cnidii, kuh-seng and the banksia rose, with eliminating dampness it is antipruritic, ward off except stench the effect of, there is good therapeutic effect with lower syndrome to gynaecology, the present invention further further includes the Essence containing Chinese medicine composition extract of the present invention, which is refined by the Chinese medicine composition and obtained；Essence long-time service of the present invention does not destroy internal microenvironment, can for a long time be used to protect genital skin mucous membrane and prevent bacterial invasion and soak fair and tender privates skin.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, more particularly to a kind of Chinese medicine composition for the maintenance of women privates, and
Essence comprising the Chinese medicine composition extract, the women privates cleaning and nursing product being prepared by the Chinese medicine composition,
Its preparation method and utilization, belong to technical field of traditional Chinese medicines.
Background technology
As the improvement of people's living standards, people also have higher requirement own health, daily health
Theory also gradual times of people's recognition and acceptance such as maintenance and disease prevention.And women is for the daily nursing and privates disease of privates
Prevention and treatment also increasingly pay attention to.Women privates is the vitals of metabolic secretion, its introitus is reproduction and uropoiesis two
Big system door, but due to the fragility of female genital tract triumph, women privates and the various germs of easy infection, trigger disease.Due to
Pruritus vulvue, leukorrhea with reddish discharge, condyloma, erosion etc. caused by infecting vaginitis, cervicitis, pelvic infecton etc. caused by germ, allow female
Property suffer untold misery, such as usually prevention and in time treatment, not only influence the physical and mental health and quality of life of women, or even can cause
It is infertile.Commercially available women privates articles for use mainly have two classes：There is the medical lotion for the treatment of and with cleaning, sterilization etc.
The privates nursing product of prophylactic function.
Chinese patent CN10145766A discloses a kind of Chinese medicinal lotion for treating vaginitis, and the washing lotion is with frutus cnidii 50-
180th, five Chinese herbal medicines such as climbing groundsel 50-180, kuh-seng 50-180, Cortex Phellodendri 30-120 are made for raw material, and CN102526301A is disclosed
A kind of compound lightyellow sophora root-selinum japenious seed bacteriostatic lotion, using the extract of kuh-seng, Cortex Phellodendri and frutus cnidii raw material as bacteriostatic active ingredients,
The washing lotion drug concentration is high, treats vaginitis available for local bactericidal, but routine use can cause flora imbalance and cannot use
In daily cleaning and nursing.CN103622839B discloses a kind of feminine care hygiene moisture paper tissue papers, with frutus cnidii, two taste of kuh-seng
Chinese medicine is active ingredient, is subject to adjuvant anhydrous sorbitol cinnamic acid ester, Jojoba wax, methyl alcohol ether -20, pH adjusting agent
Lactic acid, PHMB, essence, polysorbas20, VE acetates, EDTA-2Na, although booster action of the moisture paper tissue papers with sterilizing and itch-relieving,
Go peculiar smell ineffective, effect is not also lasting.
The content of the invention
It is an object of the invention to provide a kind of Chinese medicine composition for the maintenance of women privates, which can use
Include frutus cnidii, kuh-seng and the banksia rose, combination of the present invention with lower syndrome, the Chinese medicine composition in prevention or treatment gynaecology
Thing has the effect of eliminating dampness is antipruritic, wards off except stench, and can be used to protect private parts for a long time with internal microenvironment is not destroyed for a long time
Skin and mucosa and prevent bacterial invasion and soak fair and tender privates skin.
In the present invention, the weight proportion of each bulk pharmaceutical chemicals is in the Chinese medicine composition：Counted using frutus cnidii parts by weight as 1, it is bitter
Join 0.3-2 parts by weight, banksia rose 0.2-0.9 parts by weight.
It is further preferred that the weight proportion of each raw material is in the composition：Counted using frutus cnidii parts by weight as 1, kuh-seng
0.5-1.5 parts by weight, banksia rose 0.4-0.7 parts by weight.
In one preferred embodiment, the weight proportion of each raw material is in the composition：Using frutus cnidii parts by weight as 1
Meter, 1.5 parts by weight of kuh-seng, 0.6 parts by weight of the banksia rose.
In one preferred embodiment, the weight proportion of each raw material is in the composition：Using frutus cnidii parts by weight as 1
Meter, 0.5 parts by weight of kuh-seng, 0.5 parts by weight of the banksia rose.
On the basis of side of the present invention, any one or more in following Chinese medicine material can also be added：Such as can be
Selected from Sophora alopecuroide, the fruit of summer cypress or Cortex Phellodendri, the parts by weight of the prescription are：Counted using frutus cnidii parts by weight as 1,0.5 parts by weight of kuh-seng,
0.5 parts by weight of the banksia rose, Sophora alopecuroide, the fruit of summer cypress or Cortex Phellodendri are 0.5 parts by weight.
Women inflammatory disease belongs to the vaginal discharge diseases of motherland's medicine, refers to the amount showed increased with, and color, matter, smell occur different
Often, or with whole body, local symptom person, also known as " leukorrhea ", " stream dirty things ".In terms of etiology and pathogenesis, traditional Chinese medicine thinks：Main disease
Because being " wet " heresy, such as《Fu Qingzhu works on obstetrics and gynecology》Say：" husband with it is lower be all wet disease." it is wet have it is inside and outside it is not.Exogenous damp refers to the damp evil of diseases caused by external factors, such as
Menstrual period, which paddle, drenches with rain, and experiences cold-dampness, or postpartum vessels of the uterus inanition, and regimen is unclean, and wet poison perverse trend is interior in an opponent's defence to invade uterus, so that conception vessel damages
Wound, dai channel are failed to keep an appointment, and cause vaginal discharge diseases.Interior wet generation has substantial connection with internal organs qi and blood functional disturbance.Treatment is with diagnosis and treatment
Based on, principle of reatment is aided with soothing the liver reinforce the kidney based on invigorating the spleen, rising Yang, dehumidifying；It is wet at the same time it is turbid can with heat transformed from yang into damp and hot,
Can also cold transformed from yin form cold-dampness, so to help with removing damp-heat, clearing heat and detoxicating, dispelling cold and removing dampness.
It is formulated source：
Select in traditional Chinese medicine and be directed to women, by the pure plant frutus cnidii, kuh-seng, the banksia rose of long-time verification
Deng being used as main formula.
Frutus cnidii has the effect such as warming kidney and enhancing yang, wind-dispelling, eliminating dampness, desinsection, first recorded in the Chinese《Sheng Nong's herbal classic》, its " housewife
Swell and ache in people's the moon, man's impotence is wet to itch, eliminating impediment gas, sharp joint, and epilepsy dislikes wound." Chinese Zhang Zhongjing《Synopsis Golden Chamber》The lower married woman of volume is miscellaneous
There are Fructus Cnidii powder side, Wen Yinzhong suppositorys in a sick piece.The Tang Dynasty king of medicine SUN Si miao《Essential Recipes for Emergent Use Worth A Thousand Gold》Carry it and end, pig are smash with frutus cnidii
Fat and apply to control mange, and have married woman side, with one liter of frutus cnidii, cloth, which is wrapped up in process, presses it, pudendal pain after also managing property.Song《Sage's Ji is total
Record》Controlled in all tinea of sore swells door and suffer from wet sore long and be not recovered person's Fructus Cnidii powder.It can be seen that its for control it is wet itch, woman is wet with lower pruritus vulvae, mange
The key medicine of sore, is praised highly by ancient Chinese medicine doctor.Volatile oil contained by it has stronger anti-trichomonal, antimycotic and other effects.
Kuh-seng, bitter are cold in nature.With heat-clearing and damp-drying drug, desinsection, the work(of diuresis.《Mingyi Bielu》：" ... treat malignant sore lower part
Ulcer ... " the Tang Dynasty《Haigoushen》：" controlling heat toxin wind, the fidgety raw sore of musculus cutaneus, red leprosy eyebrow takes off ... "《The southern regions of the Yunnan Province book on Chinese herbal medicine》：" cool blood, relieving heat toxin,
Scabies leprosy, impetigo poison.Pruitus is treated, blood wind tinea sore, naughty white bits, discharging fresh blood stool, has blood in stool.Disappear wind, detumescence poison, acute purulent lymphadenitis." existing
Show to contain a variety of alkaloids, such as matrine, oxymatrine in kuh-seng for composition Study, modern pharmacological studies have shown that it is in body
There is different degrees of inhibitory action to some common dermatophytes outside, separately there is anti-trichomonal effect etc., be the treatment all diseases of skin
Key medicine.
The banksia rose, nature and flavor are pungent, bitter, temperature, its energy promoting qi circulation and relieving pain, warming middle-JIAO for easing the stomach.《This warp》：" main perverse trend, wards off malicious epidemic disease, and Qiang Zhi is main
Leaching dew."《Herbal justice》：The banksia rose, aroma are strong and rich.Though clean ancient meaning smell is all thick, when main sedimentation, its right gas is strong, medicine
In have this simply, then the perfume that boils hears houseful, must can not be generally with for drop.《This warp》Main perverse trend, wards off malicious epidemic disease person, and fragrance is able to ward off except dirty
Dislike, epidemic disease scrofula causes harm, nothing but haze stench, it is sufficient to which patient, banksia rose virtue is strong, can eliminate foul gas certainly.
Upper three tastes energy eliminating dampness is antipruritic, wherein frutus cnidii, the key medicine that kuh-seng is dark and damp all diseases of itching outside married woman, banksia rose fragrance and energy
Ward off and remove dirty evil, three medicines share, then damp and hot to go, and all itch must be stopped, and have good therapeutic effect for all diseases of vulva caused by damp evil.
Another aspect of the invention, there is provided a kind of women privates routine servicing Essence, it includes traditional Chinese medicine effective ingredient
And acceptable assistant, wherein the traditional Chinese medicine effective ingredient is frutus cnidii, kuh-seng and the banksia rose, the acceptable assistant is carried selected from oiliness
Body, surfactant, cosurfactant, bacteriostatic agent, tyrosinase inhibitor, pH adjusting agent and essence.The tyrosinase
Inhibitor is selected from peony extract or radix paeoniae alba extraction.The peony extract or radix paeoniae alba extraction can voluntarily be extracted,
Can directly buy finished product extract from the market.
In one embodiment of the invention, there is provided a kind of system for preparing women privates routine servicing Essence of the present invention
Preparation Method, including：Bulk pharmaceutical chemicals extracting in water volatile oil, it is spare to collect volatile oil；Aqueous extracts filter, after concentration, alcohol precipitation filtering, on
Clear liquid is concentrated to remove alcohol, obtains Aqueous extracts part, by the above-mentioned volatile oil of gained, Aqueous extracts part, pure water, vitamin C, vitamin
E, oiliness carrier, surfactant, cosurfactant, bacteriostatic agent, TYR enzyme inhibitor and essence or essential oil, according to certain
Ratio be uniformly mixed, you can obtain.
In the present invention, the oiliness carrier is selected from crude vegetal such as peppermint oil, litsea citrate oil, olive oil etc., natural ore deposit
Thing oil such as atoleine, semi-synthetic or fully synthetic oils such as oleic acid, middle carbochain triglyceride；The surfactant is selected from phosphatide
Class (such as soybean lecithin or lecithin), Triton X-100 class, poly yamanashi esters, office's ethylene oxide castor oil and derivative
Class, saponins.The cosurfactant is selected from short-chain alcohols, organic Ammonia, alkyl element acids, single double alkyl acid glyceryls
Class, polyoxyethylene ether fatty ester class；The bacteriostatic agent is selected from anesin, sorbic acid and its esters, Phenoxyethanol, chlorine oneself
Fixed and its and gluconate, diacetate and dihydrochloride, this methanol, benzoic acid and its esters and esters, benzalkonium chloride, benzene
Prick bromine ammonium, benzene pricks ammonium saccharin, 4-HBA and its esters and esters；The essential oil or essence are selected from natural essential oil or conjunction
Into essence, including peppermint oil, litsea citrate oil, perilla herb oil, lemon or essence, lily essential oil or essence, Rosa Damascana or perfume (or spice)
Essence, green cucumber essential oil or essence, narcissus essential oil or essence, yulan essential oil or essence, smear tea essential oil or essence, osmanthus essential oil or essence
Deng the flavouring with aromatic odor.
The selection principle of surfactant
(1) HLB value of surfactant is contemplated that first.W/o type micro emulsion is easily formed between 3~6,8~18
Between easily formed O/W type micro emulsions, in addition by ionic and it is non-ionic mixing application increasing can be played in wide temperature range
Molten effect, is significantly expanded the scope of microemulsion region.
(2) it is also contemplated that the security of surfactant.Should possess nontoxic, nonirritant, good pharmacological reaction invariably, have good
The features such as biocompatibility got well.
(3) the ionic of surfactant is considered.Most of cationic surfactant is amine or quaternary ammonium salt, in pH3~7
In the range of work；Anion surfactant requires medium pH ＞ 8；Nonionic surface active agent is in the range of pH3~10
Applicable, electrolyte or the ionic of medicine influence very little to it.
In the present invention select Cremophor EL-35 (Emulsifier EL-60), Tween-80 (Tween-80),
Cremophor RH-40 (Crodaret), HS-15 (polyethylene glycol-12-hydroxystearate) are surface-active
Agent is investigated.The result shows that the extracted gained volatile oil of bulk pharmaceutical chemicals is in Cremophor EL-35 (Emulsifier EL-60)
Solubility highest, as surfactant.
The selection of cosurfactant
Absolute ethyl alcohol, propane diols are selected in the present invention, PEG-400 is investigated for cosurfactant.Different helps table
For face activating agent to the solubilized variant of volatile oil, its micro emulsion formed is propane diols to solubilising power>PEG-400>Anhydrous second
Alcohol, therefore it is cosurfactant to select propane diols.
Specifically, the preparation method of the conditioning liquid is：The frutus cnidii, kuh-seng and the banksia rose of recipe quantity are weighed, is ground into thick
Powder, adds 6 times of amount water extraction volatile oil, it is spare to collect volatile oil；Aqueous extracts filter, and it is 1.10-1.14 (50 to be concentrated into relative density
DEG C) medicinal extract, add ethanol to determining alcohol be 60%, stand overnight, filter, decompression filtrate recycling ethanol to no alcohol taste, obtains water and carries
Liquid part is spare.By above-mentioned volatile oil, propane diols, Emulsifier EL-60 EL35, peppermint oil, vitamin E, oiliness carrier, benzene
Oxyethanol and essence or essential oil, are uniformly mixed, obtain clear microemulsion liquid, then prick drug extract, pure water, vitamin C, benzene
Oronain, pigment are uniformly mixed with microemulsion solution according to a certain percentage, both.
Process aspect
1) Hydrolysis kinetics are extracted traditional medicine volatile oil and water soluble ingredient, are taken into account using modern advanced extraction and purification process
The integrality and validity of each constituents, extract Antibacterial Constituents, are played while gentle nursing and clean antibacterial effect.
2) preparation uses microemulsion technology, and aqueous active ingredient and oiliness active ingredient are fully combined, and it is steady to form thermodynamics
Fixed isotropic transparency liquid, is easy to absorb, skin is pleasant.
3) acid-base balance adjusts solution ph using vitamin C needed by human, forms faintly acid formula, and protection privates is put down
Weighing apparatus, improves self-cleaning ability, and irritating at the same time in reduction, supplements appropriate nutrient.
4) smell adjusts with color and luster smell and uses essential oil, also in longer period of time body note can be kept pleasant after use；Color
Pool adjusts and uses natural pigment, solution colour is got close to nature, while also certain anti-oxidation efficacy.
With eliminating dampness it is antipruritic, ward off except stench the effect of, and for a long time with not destroying internal microenvironment, can be used to protect for a long time
Protect genital skin mucous membrane and prevent bacterial invasion and soak privates skin.
Essence can be sprayed directly on to privates by use aspect, or Essence is sprayed on protection pad, and vulva sticks during use, no
Human vagina's normal ph is influenced, does not destroy internal microenvironment, convenient and efficient, body-sensing is felt well profit.
Embodiment
In the following, the implementation to technical solution is described in further detail.
It will be appreciated by those of skill in the art that although the following description is related to many of embodiment for the present invention
Ins and outs, but be only for not meaning that any restrictions for illustrating the example of the principle of the present invention.The present invention can be applicable in
Occasion outside different from ins and outs exemplified below, without departing from the principle of the present invention and spirit.
, may pair can be in description in the present specification in addition, miscellaneous in order to avoid being limited to the description of this specification
The portion of techniques details obtained in prior art data has carried out the processing such as omission, simplification, accommodation, this technology for this area
It will be understood by for personnel, and this does not interfere with the open adequacy of this specification.
Embodiment 1
Raw material is weighed by following proportionings：Frutus cnidii 10g, banksia rose 6g, kuh-seng 15g
Preparation method is following (technique 1)：Raw material frutus cnidii, the banksia rose and kuh-seng are mixed, when 5 times of amount water decoctions 1 of addition are small,
Filtering, takes filtrate, and filter residue decocts 0.5h with 3 times of amount water again, and filtering, merges filtrate twice, obtain traditional Chinese medicine liquid.
Or (technique 2)：The frutus cnidii, kuh-seng and the banksia rose of recipe quantity are weighed, is ground into coarse powder, adds 6 times of amount water extractions to wave
Hair oil, it is spare to collect volatile oil；Aqueous extracts filter, and are concentrated into the medicinal extract that relative density is 1.10-1.14 (50 DEG C), add ethanol extremely
Determining alcohol is 60%, is stood overnight, and filtration, decompression filtrate recycling ethanol to no alcohol taste, it is spare to obtain Aqueous extracts part；By Aqueous extracts
Part merges to obtain Chinese medicine composition extract with volatile oil.
Embodiment 2
Raw material is weighed by following proportionings：Frutus cnidii 30g, banksia rose 15g, kuh-seng 15g
Preparation method is as follows：The frutus cnidii, kuh-seng and the banksia rose of recipe quantity are weighed, is ground into coarse powder, adds 6 times of amount water extractions to wave
Hair oil, it is spare to collect volatile oil；Aqueous extracts filter, and are concentrated into the medicinal extract that relative density is 1.10-1.14 (50 DEG C), add ethanol extremely
Determining alcohol is 60%, is stood overnight, and filtration, decompression filtrate recycling ethanol to no alcohol taste, it is spare to obtain Aqueous extracts part；By Aqueous extracts
Part merges to obtain Chinese medicine composition extract with volatile oil.
Embodiment 3
Raw material is weighed by following proportionings：Frutus cnidii 15g, banksia rose 8g, kuh-seng 15g
Preparation method is as follows：The frutus cnidii, kuh-seng and the banksia rose of recipe quantity are weighed, is ground into coarse powder, adds 8 times of amount water extractions to wave
Hair oil, it is spare to collect volatile oil；Aqueous extracts filter, and are concentrated into the medicinal extract that relative density is 1.10-1.14 (50 DEG C), add ethanol extremely
Determining alcohol is 60%, is stood overnight, and filtration, decompression filtrate recycling ethanol to no alcohol taste, it is spare to obtain Aqueous extracts part；By Aqueous extracts
Part merges to obtain Chinese medicine composition extract with volatile oil.
Embodiment 4
Raw material is weighed by following proportionings：Frutus cnidii 10g, banksia rose 4g, kuh-seng 12g
Preparation method is as follows：The frutus cnidii, kuh-seng and the banksia rose of recipe quantity are weighed, is ground into coarse powder, adds 8 times of amount water extractions to wave
Hair oil, it is spare to collect volatile oil；Aqueous extracts filter, and are concentrated into the medicinal extract that relative density is 1.10-1.14 (50 DEG C), add ethanol extremely
Determining alcohol is 60%, is stood overnight, and filtration, decompression filtrate recycling ethanol to no alcohol taste, it is spare to obtain Aqueous extracts part；By Aqueous extracts
Part merges to obtain Chinese medicine composition extract with volatile oil.
Embodiment 5
Raw material is weighed by following proportionings：Frutus cnidii 20g, banksia rose 13g, kuh-seng 24g
Preparation method is as follows：The frutus cnidii, kuh-seng and the banksia rose of recipe quantity are weighed, is ground into coarse powder, adds 8 times of amount water extractions to wave
Hair oil, it is spare to collect volatile oil；Aqueous extracts filter, and are concentrated into the medicinal extract that relative density is 1.10-1.14 (50 DEG C), add ethanol extremely
Determining alcohol is 60%, is stood overnight, and filtration, decompression filtrate recycling ethanol to no alcohol taste, it is spare to obtain Aqueous extracts part；By Aqueous extracts
Part merges to obtain Chinese medicine composition extract with volatile oil.
The preparation process of 6 Chinese medicine composition extract of embodiment investigates
The investigation extraction process of amount of water：Frutus cnidii 50g, kuh-seng 25g, banksia rose 25g are taken, extracts volatile oil, is added different
The water of amount, steam extraction volatile oil 5h, measure volatile oil must be measured, and decocting liquid measure dry cream must be measured, and be shown in Table 1.
The investigation of 1 amount of water of table
The result shows that add 6 times of amount water and 8 times of amount water volatile oil must measure it is higher, and decocting liquid dry cream must measure it is also higher, but 6
It is not much different again with 8 times, there was no significant difference, and to simplify technique, reducing production cost, technique is determined as plus 6 times are measured water extraction
Volatile oil, decocting liquid filtration.
2) process for refining is investigated
According to above-mentioned selection process, frutus cnidii 300g, kuh-seng 150g, banksia rose 150g are taken, extracts volatile oil, gained decocting liquid
It is 1.08 to be concentrated into density, is equally divided into 3 parts, and selection acid is heavy, 3 kinds of techniques progress extracting solutions of alcohol precipitation and activated carbon removal of impurities respectively
Refined, centrifugation, takes supernatant, observation color, clarity, and carries out the bacteriostatic test verification of golden staphylococci, as a result such as table 2.
As control, frutus cnidii 100g, kuh-seng 50g, banksia rose 50g are taken, directly carries out water boiling and extraction, extracting solution is concentrated into
Relative density is 1.08, is carried out using alcohol precipitation mode after refining, centrifugation, takes supernatant, and carry out the antibacterial reality of golden staphylococci
Verification
The different process for refining of table 2 are investigated
Find out from result of the test, although activated carbon removal of impurities after solution colour shoal, at the same time bacteriostatic active ingredients also have compared with
Big loss, undesirable, acid is heavy and the method for alcohol precipitation does not influence drug effect, but the refined rate that acid sinks is low, selects alcohol precipitation preferable.Through carrying
Volatile oil fungistatic effect is taken to be better than the fungistatic effect directly decocted.
3) alcohol precipitation process is preferred：
With single factor exploration method, using dry spun as index, relative density and alcohol precipitation concentration to medicinal extract alcohol precipitation carry out
Investigate.Each taste Chinese medicine 1200g altogether is taken in each prescription ratio, Aqueous extracts are made by preferable technique, is filtered, is concentrated into certain thick
Degree, mixes, is divided into 6 parts, water-bath respectively is concentrated into relative density 1.05,1.09,1.12,1.12,1.12,1.15 (60 DEG C), adds
Enter 95% ethanol to regulation concentration of alcohol alcohol precipitation, be sufficiently stirred mixing, stand overnight, centrifuge (3500rpm*20min), measure is dry
Cream yield.It the results are shown in Table 3
3 alcohol precipitation process of table and relative density investigate experiment
When alcohol precipitation process fixation concentration of alcohol is 60%, medicinal extract relative density is optimal for 1.12, due to medicinal extract relative density
More difficult control, can select the scope of 1.11-1.13.When fixed medicinal extract relative density is 1.12,60% ethanol and 70% ethanol contain
Amount, in order to cost-effective, selection alcohol precipitation concentration is appropriate for 60%.
Finally definite alcohol precipitation process parameter is：Medicinal extract relative density 1.11-1.13 (60 DEG C), concentration of alcohol 60%.
The test of pesticide effectiveness and data of 7 composition of embodiment
Composition square foundation (different ratio) extracting solution has Escherichia coli in bacteriostasis, antibacterial action result such as table 4
Bacteriostasis of the 4 different ratio composition extracting solution of table to Escherichia coli
Compared with blank control group, * P<0.01；Compared with Example 3,#P<0.05。
Test result indicates that square foundation different ratio is formed a team, Escherichia coli have certain bacteriostasis, real with technique
Apply example 1 and 2 effect of embodiment is the most notable, compared with other proportioning groups, difference has conspicuousness (P<0.05).
Composition square foundation (different ratio) extracting solution has staphylococcus aureus in bacteriostasis, specific data such as table 5.
Bacteriostasis of the 5 different ratio composition extracting solution of table to staphylococcus aureus
Compared with blank control group, * P<0.01；Compared with Example 3,#P<0.05。
Test result indicates that square foundation different ratio is formed a team, Escherichia coli have certain bacteriostasis, real with technique
Apply example 1 and 2 effect of embodiment is the most notable, compared with other proportioning groups, difference has conspicuousness (P<0.05).
Embodiment 8 adds the test of pesticide effectiveness research of the Chinese medicine composition after other flavour of a drug
Traditional Chinese medicine composition formula 1 (main ingredient frutus cnidii 30g, kuh-seng 15g, banksia rose 15g), (the main ingredient snake of Traditional Chinese medicine composition formula 2
Machine tool 30g, kuh-seng 15g, banksia rose 15g, fruit of summer cypress 15g), Traditional Chinese medicine composition formula 3 (main ingredient frutus cnidii 30g, kuh-seng 15g, the banksia rose
15g, Cortex Phellodendri 15g), Traditional Chinese medicine composition formula 4 (main ingredient frutus cnidii 30g, kuh-seng 15g, banksia rose 15g, Sophora alopecuroide 15g)
1st, Traditional Chinese medicine composition formula 1-4 extracts have Escherichia coli bacteriostasis, antibacterial action result such as following table 6.
Bacteriostasis of the different prescriptions of table 6 to Escherichia coli
Note：Compared with blank control group, P ＜ 0.01
2. the antibacterial action of pair staphylococcus aureus
Essence is with 1-4 to having bacteriostasis, specific data such as table 7 below to staphylococcus aureus.
Bacteriostasis of the different prescriptions of table 7 to staphylococcus aureus
Note：Compared with blank control group, P ＜ 0.01
9 clinical case of embodiment
Such as《Fu Qing housewife section》It is described：Husband with it is lower be all wet disease.For many years, for gynaecology band lower class disease " damp evil " this
The one crucial interpretation of the cause, onset and process of an illness, by constantly putting into practice, gradually finds out the core prescription of the conditioning and treating disease：In every dose, frutus cnidii 8-
40g, banksia rose 4-20g, kuh-seng 10-60g, with the main gynaecology's band lower class disease as caused by this " wet " evil interpretation of the cause, onset and process of an illness of core prescribed treatment
Disease, within the above range, according to the specific constitution of different patients, the age is suitably adjusted dosage, with the gained of technique 2 effectively
Component is treated.Fully to show therapeutic effect of the Chinese medicinal composition preparation of the present invention in terms of gynecological disease, have selected
The similar patient 60 of medical history, the state of an illness, cardinal symptom is shown as：With lower exception, band is shown as in vain or with Huang, vaginal fluid
It is more, and with stench peculiar smell, vulva is moist, and itch is uncomfortable.Treatment method smokes washout, menstrual period rinsing vulva, the moon before menstruation for the moon
Washout treatment is smoked after, treatment cycle is 2-6 months, and therapeutic process observation patient symptom improves situation.Suffer from during whole treatment
Person does not occur any such as flush adverse reaction, the lower abnormal symptom of band that patient occurs, such as excess secretion, band it is white or
Band is yellow, sticky and be significantly improved by the symptom such as fish-stench, itch discomfort, vulva humidity, below by way of typical case into
Row explanation, however, the present invention is not limited thereto.
Clinical case 1
Mr. Li：Disease symptoms are premenstrual (starting after ovulation) for the moon, and vaginal fluid is more, and white or yellow, vulva is moist,
There is itch uncomfortable frequently, eat irritable food exacerbation of symptoms, it is easily irritable, or swollen breasts, urine color is yellow, under dialectical category is damp and hot
The vaginal discharge diseases of note, principle of reatment are eliminating dampness and heat, are helped with the desinsection that detoxifies.Assertive evidence damp-heat accumulation is under, damage times two arteries and veins of band, therefore
The product for selecting clearing damp and promoting diuresis, removing damp-heat during medication more.External used medicine selects 10 grams of frutus cnidii, 6 grams of the banksia rose, kuh-seng 15
Gram month before menstruation smoked washout, menstrual period rinsing vulva, smokes washout treatment, fully recovers after treating 3 menstrual cycles after menstruation.
Clinical case 2
Mr. Wang：Disease symptoms are more for vaginal fluid, yellow or yellow green, and sticky to have fish-stench, vulva is moist, itch
Discomfort, dizzy, irritable, urine color is yellow, and stool is smelly, dialectical category stagnated heat of liver channel vaginal discharge diseases.30 grams of external application frutus cnidii, the banksia rose
15 grams, kuh-seng smokes washout for 15 grams months before menstruation, and menstrual period rinsing vulva, smokes washout treatment, fully recover from an illness after treating 2 menstrual cycles after menstruation
More.
Clinical case 3
Disease symptoms are mainly shown as abnormal leucorrhea jaundice, have peculiar smell, and vulva is moist, and privates has itch frequently, and frequent micturition is simultaneously
With scorching hot feeling of pain, totally 15 people, divides three groups, every group of 5 people.Each group adds other medicines and is controlled on the basis of square foundation
Treat, one of which external application frutus cnidii 30g, kuh-seng 15g, banksia rose 15g, Cortex Phellodendri 15g；Another group of external application frutus cnidii 30g, kuh-seng 15g,
Banksia rose 15g, fruit of summer cypress 15g；3rd group of external application frutus cnidii 30g, kuh-seng 15g, banksia rose 15g, Sophora alopecuroide 15g；The moon smokes washout before menstruation,
Menstrual period rinsing vulva, smokes washout treatment after menstruation, itch and frequent micturition improve with scorching hot pain symptom after treating 2-3 weeks, and one
Disappear substantially after a month, continual cure, leukorrhea recovers normal after two menstrual cycles, is almost recovered.
10 privates of embodiment conserves Essence specific formula and preparation process
The frutus cnidii 30g, kuh-seng 15g and banksia rose 15g of recipe quantity are weighed, is ground into coarse powder, adds 6 times of amount water extraction volatilizations
Oil, it is spare to collect volatile oil；Aqueous extracts filter, and are concentrated into the medicinal extract that relative density is 1.10-1.14 (50 DEG C), add ethanol to alcohol
Concentration is 60%, is stood overnight, and filtration, decompression filtrate recycling ethanol to no alcohol taste, it is spare to obtain Aqueous extracts part.By above-mentioned volatilization
Oil, propane diols, Emulsifier EL-60 EL35, peppermint oil, vitamin E, oiliness carrier, Phenoxyethanol and essence or essential oil, are mixed
Close uniform, obtain clear microemulsion liquid, then by drug extract, pure water, vitamin C, benzalkonium chloride, tyrosinase inhibitor,
Pigment is uniformly mixed with microemulsion solution according to a certain percentage, both.Tyrosinase inhibitor can be peony extract or white
Any one (can also change the radix paeoniae alba extraction in following table into peony extract) in Chinese herbaceous peony extract, addition is 0.5g,
The two is purchased from Xi'an Yuan Sen bio tech ltd, and in peony extract, paeonol content is not less than 2%, Radix Paeoniae Alba extraction
Paeoniflorin content is not less than 3% in thing.
8 privates of table maintenance Essence specific formula (60 days dosages, 60g crude drugs)
11 privates of embodiment conserves Essence whitening and the experiment of fair and tender Effect study and data
Tyrosinase has various features catalytic activity, can not only be used as tyrosine hydroxylase, dopa-oxidase, but also can
As 5,6- dihydroxy indole oxidizing ferment, to be played a crucial role in melanin generating process.Tyrosinase activity
Height, i.e., act on the generation of its product melanin with tyrosine and increase, find expression on skin of face and produce various blackspots.Therefore, suppress
Tyrosinase activity is a kind of effective approach for reducing melanin generation.Often utilize and suppress tyrosinase activity experimental study screening
The medicine of the excessive disease of cutaneous pigmentation is treated, and some can be applied to whitening beauty as the material of tyrosinase inhibitor
In cosmetics.This experiment uses in-vitro method, using aspergillus and ursin as positive drug, carries out privates Essence and suppresses tyrosinase
Activity experiment, experimental result shows, adding peony extract and radix paeoniae alba extraction can press down in various degreePropylhomoserin enzyme
Activity, plays the role of suppressing melanin formation.
12 privates of embodiment conserves Essence clinical treatment typical case
Mr. Wang, disease symptoms are pruritus vulvue, red and swollen cusalgia, and leukorrhea is more, and into milky mucus shape, urine color is yellow and aches
Bitterly, the visible more blackspot near privates, is treated using Essence 1 of the present invention, and the Essence of single recipe quantity is direct
Privates is sprayed at, is substantially mitigated using itch after two weeks and cusalgia sense, disappeared after one month, is controlled after 3 menstrual cycles treat
More, leukorrhea is reduced, and color is normal, and blackspot has thin out trend；After a year and a day, the blackspot primary colors near privates is substantially thin out.
Obvious adverse reaction is not observed in whole therapeutic process.
In so-and-so, because often going on business, physiological periods cannot be nursed one's health for a long time, and disease symptoms show as abnormal leucorrhea increasing
It is more, lochiorrhagia, urine urgency-frequency, vulva it is red and swollen and when have itch etc., visible blackspot deposition but unobvious near privates, use
Curing fluid of the present invention is treated, and the Essence 2 of single recipe quantity is sprayed on maintenance pad, protection pad is then rested and is affixed on private
Locate, red and swollen itch phenomenon disappears after a menstrual cycle, and after 3 menstrual cycles treat, lochia stench phenomenon obtains big change
Kind, basic to cure, nearby blackspot color slightly shoals privates；After 6 menstrual cycles, menstruation recovers normal completely, near privates
The light color blackspot of blackspot disappears substantially.Obvious adverse reaction is had no during whole medication.
Finally, it will be appreciated by those of skill in the art that various modifications can be made to the above embodiment of the present invention, become
Type and replacement, it is each fallen within such as protection scope of the present invention defined in the appended claims.
Claims (10)
1. it is a kind of for women privates maintenance Chinese medicine composition, the Chinese medicine composition include bulk pharmaceutical chemicals frutus cnidii, kuh-seng and
The banksia rose, the weight proportion of each bulk pharmaceutical chemicals are：Counted using frutus cnidii parts by weight as 1, kuh-seng 0.5-1.5 parts by weight, banksia rose 0.4-0.7 weights
Measure part.
2. Chinese medicine composition according to claim 1, the weight proportion of each raw material is in the composition：With frutus cnidii weight
Part is counted for 1,1.5 parts by weight of kuh-seng, 0.6 parts by weight of the banksia rose.
3. Chinese medicine composition according to claim 1, the weight proportion of each raw material is in the composition：With frutus cnidii weight
Part is counted for 1,0.5 parts by weight of kuh-seng, 0.5 parts by weight of the banksia rose.
4. according to Chinese medicine composition described in any one claim in claim 1-3, choosing is further included in the composition
One or more from the fruit of summer cypress, Cortex Phellodendri or Sophora alopecuroide bulk pharmaceutical chemicals.
5. a kind of women privates conserves Essence, carried comprising Chinese medicine composition described in any one claim in claim 1-4
Thing, tyrosinase inhibitor and acceptable assistant are taken, the tyrosinase inhibitor is selected from peony extract or radix paeoniae alba extraction,
The acceptable assistant is selected from oiliness carrier, surfactant, cosurfactant, bacteriostatic agent, pH adjusting agent and essence.
6. women privates maintenance Essence according to claim 5, wherein the privates elite liquid and preparation method thereof includes：Take place
Bulk pharmaceutical chemicals extracting in water volatile oil in side, it is spare to collect volatile oil；Aqueous extracts are filtered, after concentration, alcohol precipitation refilter, supernatant
Liquid concentration removes alcohol, Aqueous extracts part is obtained, by gained volatile oil, Aqueous extracts part and pure water, vitamin C, vitamin E, oiliness
Carrier, surfactant, cosurfactant, bacteriostatic agent, tyrosinase inhibitor and essence or essential oil, according to a certain percentage
It is uniformly mixed, to obtain the final product.
7. women privates maintenance Essence, wherein the method are according to claim 6：The bulk pharmaceutical chemicals in prescription are taken to add water
Volatile oil is extracted, it is spare to collect volatile oil；Aqueous extracts are filtered, and after concentration, alcohol precipitation refilter, supernatant concentration removes alcohol, obtains water
Extract part；By above-mentioned volatile oil, propane diols, Emulsifier EL-60 EL35, peppermint oil, vitamin E, oiliness carrier, benzene oxygen
Ethanol and essence or essential oil, are uniformly mixed, obtain clear microemulsion liquid, and drug extract, pure water, vitamin C, benzene then are pricked chlorine
Ammonium, tyrosinase inhibitor, pigment are uniformly mixed with microemulsion solution, both.
8. any one claim in Chinese medicine composition described in any one claim or claim 5-7 in claim 1-4
Utilization of the women privates maintenance Essence in preparing for maintenance women privates preparation.
9. any one claim in Chinese medicine composition described in any one claim or claim 5-7 in claim 1-4
Utilization of the women privates maintenance Essence in syndrome medicament preparation under preparing with prevention or treatment gynaecology band.
10. any one claim in Chinese medicine composition described in any one claim or claim 5-7 in claim 1-4
The Essence is being prepared with the utilization in whitening, the fair and tender women privates skin preparation of wetting.
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Application publication date: 20180417 |