CN107875433A - A kind of preparation method of quick-acting haemostatic powder type looped fabric - Google Patents
A kind of preparation method of quick-acting haemostatic powder type looped fabric Download PDFInfo
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- CN107875433A CN107875433A CN201711241962.6A CN201711241962A CN107875433A CN 107875433 A CN107875433 A CN 107875433A CN 201711241962 A CN201711241962 A CN 201711241962A CN 107875433 A CN107875433 A CN 107875433A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/62—Compostable, hydrosoluble or hydrodegradable materials
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F11/00—Chemical after-treatment of artificial filaments or the like during manufacture
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F9/00—Artificial filaments or the like of other substances; Manufacture thereof; Apparatus specially adapted for the manufacture of carbon filaments
-
- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04B—KNITTING
- D04B1/00—Weft knitting processes for the production of fabrics or articles not dependent on the use of particular machines; Fabrics or articles defined by such processes
- D04B1/14—Other fabrics or articles characterised primarily by the use of particular thread materials
-
- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04B—KNITTING
- D04B21/00—Warp knitting processes for the production of fabrics or articles not dependent on the use of particular machines; Fabrics or articles defined by such processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
-
- D—TEXTILES; PAPER
- D10—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B2201/00—Cellulose-based fibres, e.g. vegetable fibres
- D10B2201/20—Cellulose-derived artificial fibres
- D10B2201/22—Cellulose-derived artificial fibres made from cellulose solutions
-
- D—TEXTILES; PAPER
- D10—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B2509/00—Medical; Hygiene
- D10B2509/02—Bandages, dressings or absorbent pads
- D10B2509/022—Wound dressings
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- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A kind of preparation method of quick-acting haemostatic powder type looped fabric, belongs to looped fabric technical field.Dissolve the chitosan in dilute acetic acid solutions, then add urea and zinc acetate is prepared into chitosan spinning solution；Structure directing agent is added in deionized water, sodium hydroxide is added after stirring, absolute ethyl alcohol is added after stirring and dissolving, tetraethoxysilance is then added dropwise heats and continues stirring and obtain colloidal sol；Colloidal sol to be prepared is filtered after being cooled to room temperature, washs, dried, and then obtains mesoporous silicon oxide in roasting；Take mesoporous silicon oxide to add in NaOH solution to stir；Make its solidification in the mixed liquor that chitosan spinning solution is sprayed into after stirring through spinning head, dry after stretching, washing, then spinned in a tensioned state, spin the yarn come and be made into looped fabric by knitting machine.The product clotting time prepared by the present invention is short, and anthemorrhagic speed is fast, and preparation method is easy and effective, is dipped in water in colourless or slightly yellow translucent thick gel, no insoluble fibre.
Description
Technical field
The invention belongs to looped fabric technical field, and in particular to a kind of preparation method of quick-acting haemostatic powder type looped fabric.
Background technology
Place's horse back of bleeding allows blood stopping flowing being called hemostasis.Four kinds of conventional Hemostasis：1. pressure, is used when wounds streamed blood
Hand pins bleeding area.2. bag, it is that gauze, bandage, elastoplast or clean cotton or use cotton goods is done to wrap up material used
Into pad.3. plug.It is to use cotton goods for the hemostasis with packs method at armpit, shoulder, mouth and nose or other blindgut wounds and tissue defect
To tightly it be clogged at the cavity or tissue defect of bleeding, until arresting hemorrhage really.4. bundle, hemostasis with tourniquet, is generally used for
It is effective to control extremity hemorrhage during operation, but the damage of N＆M may be caused, can also causes because of limb ischemia
Systemic complications, not in the case of last resort, this method is not used.
Emergency haemostatic is developed mainly for the emergency that The blood streamed down in wound.In a short period of time
(3 min) just can control the emergency as bleeding sustainer, for further medical treatment win preciousness when
Between.The 80's of 20th century Francis X.Hursey be not intended to be found that zeolite molecular sieve have excellent anastalsis and in
Patent is applied within 1989.At the beginning of 2002, Z-Medica companies set up the new of special Development and Production trade name Quikclot
Type hemostatic material, the material are to be made with 75% synthetic zeolite (A type zeolites, LTA structures) for substrate and 25% clay
The composite type zeolite hemostatic material mixed for adhesive, at present using the new hemostatic material that zeolite molecular sieve material is main body
Material Quikclot has obtained U.S. FDA approval listing, no matter in laboratory or in practice (especially in field operation battlefield
), its haemostatic effect and the aspect of raising survival rate two are better than traditional hemostatic material.Put because Quikclot hemostatic materials have
The characteristics of heat is high, wound tissue can be burnt.
China Patent No. CN100345597C has been disclosed mesopore molecular sieve hemostatic material and preparation method thereof, still
They simply emphasize simple mesoporous material (main component is silica and other oxides), but due to not passing through
Others processing, haemostatic effect are relatively poor.Thus exploitation has the excellent haemostatic effect low hemostatic material of side effect simultaneously, is
The consistent target of researcher.
The content of the invention
The technical problem of solution：For above-mentioned technical problem, the present invention provides a kind of preparation of quick-acting haemostatic powder type looped fabric
Method, possess anthemorrhagic speed it is fast, without insoluble fibre, preparation process is simple the advantages that.
Technical scheme：A kind of preparation method of quick-acting haemostatic powder type looped fabric, the preparation method comprise the following steps：
5 ~ 10 mass parts chitosans are dissolved in 75 ~ 86 mass parts 2 ~ 5wt.% dilute acetic acid solutions by step 1, then add 2 ~ 5
Mass parts urea and 1 ~ 3 mass parts zinc acetate are prepared into chitosan spinning solution；
Step 2 adds 0.5 ~ 1 mass parts structure directing agent in 100 ~ 130 mass parts deionized waters, after stirring 10 ~ 15min
1 ~ 2 mass parts sodium hydroxide is added, 4 ~ 6 mass parts absolute ethyl alcohols is added after stirring and dissolving, 1 ~ 2 mass parts is then added dropwise
Tetraethoxysilance is heated to 80 ~ 90 DEG C and continues the h of stirring 15 ~ 18 to obtain colloidal sol；
Step 3 is filtered after colloidal sol prepared by step 2 is cooled to room temperature, washed, drying, then at a temperature of 300 ~ 420 DEG C
4 ~ 5.5 h of roasting obtain mesoporous silicon oxide；
It is molten that the mesoporous silicon oxide that step 4 takes 2 ~ 4 mass parts step 3 to prepare adds the wt.% NaOH of 60 ~ 75 mass parts 2 ~ 4
Stirred in liquid；
Chitosan spinning solution prepared by step 1 is sprayed into step 4 through a diameter of 0.1mm ~ 1mm spinning heads and prepared by step 5
Stir after mixed liquor in make its solidification, dry at a temperature of 75 ~ 78 DEG C 30 after stretching, washing in a tensioned state ~
60min, then spinned, spin the yarn come and be made into looped fabric by knitting machine.
Preferably, 6 mass parts chitosans are dissolved in the wt.% dilute acetic acid solutions of 80 mass parts 4 in the step 1,
Then 3 mass parts urea are added and 2 mass parts zinc acetates are prepared into chitosan spinning solution.
Preferably, structure directing agent is TPAOH in the step 2.
Preferably, 1 mass parts structure directing agent is added in 120 mass parts deionized waters in the step 2, stirring
1.5 mass parts sodium hydroxides are added after 14 min, 5 mass parts absolute ethyl alcohols are added after stirring and dissolving, are then added dropwise 1.5
Mass parts tetraethoxysilance be heated to 85 DEG C and continue stir 16 h obtain colloidal sol.
Preferably, obtain mesoporous silicon oxide in 350 DEG C of h of roasting temperature 5 in the step 3.
Preferably, the mesoporous silicon oxide for taking 3 mass parts step 3 to prepare in the step 4 adds 66 mass parts 3
Stirred in wt.% NaOH solutions.
Preferably, 45 min are dried in the step 5 at a temperature of 77 DEG C.
Beneficial effect：1. quick-acting haemostatic powder type of the present invention knitting is arranged in warm water, solution is in colourless or slightly yellow half
Transparent thick gel, no insoluble fibre；
2. preparation process of the present invention strictly observes sterile working standard, Sterility testing is qualified；
3. quick-acting haemostatic powder type looped fabric of the present invention is short by adding the material clotting time such as chitosan, tetraethoxysilance, only
Blood speed is fast, and preparation method is easy and effective.
Embodiment
Embodiment 1
A kind of preparation method of quick-acting haemostatic powder type looped fabric, the preparation method comprise the following steps：
5 mass parts chitosans are dissolved in 75 mass parts 2wt.% dilute acetic acid solutions by step 1, then add 2 mass parts urea
Chitosan spinning solution is prepared into 1 mass parts zinc acetate；
Step 2 adds 0.5 mass parts structure directing agent in 100 mass parts deionized waters, and 1 matter is added after stirring 10min
Part sodium hydroxide is measured, 4 mass parts absolute ethyl alcohols are added after stirring and dissolving, the heating of 1 mass parts tetraethoxysilance is then added dropwise
To 80 DEG C and continue stir 15 h obtain colloidal sol；
Step 3 is filtered after colloidal sol prepared by step 2 is cooled to room temperature, washed, drying, then in 300 DEG C of roasting temperatures
4 h obtain mesoporous silicon oxide；
The mesoporous silicon oxide that step 4 takes 2 mass parts step 3 to prepare, which is added in the wt.% NaOH solutions of 60 mass parts 2, to be stirred
Uniformly；
Chitosan spinning solution prepared by step 1 is sprayed into step 4 through a diameter of 0.1mm ~ 1mm spinning heads and prepared by step 5
Stir after mixed liquor in make its solidification, 30min is dried at a temperature of 75 DEG C in a tensioned state after stretching, washing,
Then spinned, spin the yarn come and be made into looped fabric by knitting machine.
Detection experiment is carried out to quick-acting haemostatic powder type looped fabric made from the present embodiment, the looped fabric of preparation is folded, cut,
By average piece weight 0.8g, area needed for hemostatic gauze is cut into, it is long：A width of 10:7 ratio, claims during cutting every 20min
Weight successively, it is found that deviation adjusts in time, specific test result is as follows：
1st, dissolubility detects：The quick-acting haemostatic powder type looped fabric 0.5g of the present invention, warm water 100mL is taken to be dissolved, solution is in nothing
Color or slightly yellow translucent sticky colloid, micro-strip opalescence, no insoluble fibre.
2nd, acid-base value detects：The quick-acting haemostatic powder type looped fabric 0.5g of the present invention is taken, after adding water 100mL to dissolve, pH is measured and exists
In the range of 6.0-8.0.
3rd, Sterility testing：Preparation process of the present invention strictly observes sterile working standard, up to specification after testing.
4th, anthemorrhagic performance is tested：Take 4 mL pigs whole bloods in advance in 25 DEG C of constant temperature water bath half an hour, first determination nature blood coagulation
Between, take 2 mL 0.2M CaCl2 Solution, the whole blood of 2 mL constant temperature is then added, it is 10 min to measure the nature clotting time.Then
Take the g of quick-acting haemostatic powder type looped fabric 0.5 of the present invention to add in 10 mL centrifuge tube, add 2 mL 0.2M CaCl2, finally add
Enter the pig whole blood after 2 mL constant temperature, start simultaneously at timing, the time of whole blood coagulation is 3min.
Embodiment 2
A kind of preparation method of quick-acting haemostatic powder type looped fabric, the preparation method comprise the following steps：
10 mass parts chitosans are dissolved in 86 mass parts 5wt.% dilute acetic acid solutions by step 1, then add 5 mass parts urine
Element and 3 mass parts zinc acetates are prepared into chitosan spinning solution；
Step 2 adds 1 mass parts structure directing agent in 130 mass parts deionized waters, and 2 mass are added after stirring 15min
Part sodium hydroxide, 6 mass parts absolute ethyl alcohols are added after stirring and dissolving, 2 mass parts tetraethoxysilances are then added dropwise and are heated to
90 DEG C and continue stir 18 h obtain colloidal sol；
Step 3 is filtered after colloidal sol prepared by step 2 is cooled to room temperature, washed, drying, then in 420 DEG C of roasting temperatures
5.5 h obtain mesoporous silicon oxide；
The mesoporous silicon oxide that step 4 takes 4 mass parts step 3 to prepare, which is added in the wt.% NaOH solutions of 75 mass parts 4, to be stirred
Uniformly；
Chitosan spinning solution prepared by step 1 is sprayed into step 4 through a diameter of 0.1mm ~ 1mm spinning heads and prepared by step 5
Stir after mixed liquor in make its solidification, 60min is dried at a temperature of 78 DEG C in a tensioned state after stretching, washing,
Then spinned, spin the yarn come and be made into looped fabric by knitting machine.
Detection experiment is carried out to quick-acting haemostatic powder type looped fabric made from the present embodiment, the looped fabric of preparation is folded, cut,
By average piece weight 0.8g, area needed for hemostatic gauze is cut into, it is long：A width of 10:7 ratio, claims during cutting every 20min
Weight successively, it is found that deviation adjusts in time, specific test result is as follows：
1st, dissolubility detects：The quick-acting haemostatic powder type looped fabric 0.5g of the present invention, warm water 100mL is taken to be dissolved, solution is in nothing
Color or slightly yellow translucent sticky colloid, micro-strip opalescence, no insoluble fibre.
2nd, acid-base value detects：The quick-acting haemostatic powder type looped fabric 0.5g of the present invention is taken, after adding water 100mL to dissolve, pH is measured and exists
In the range of 6.0-8.0.
3rd, Sterility testing：Preparation process of the present invention strictly observes sterile working standard, up to specification after testing.
4th, anthemorrhagic performance is tested：Take 4 mL pigs whole bloods in advance in 25 DEG C of constant temperature water bath half an hour, first determination nature blood coagulation
Between, take 2 mL 0.2M CaCl2 Solution, the whole blood of 2 mL constant temperature is then added, it is 10 min to measure the nature clotting time.Then
Take the g of quick-acting haemostatic powder type looped fabric 0.5 of the present invention to add in 10 mL centrifuge tube, add 2 mL 0.2M CaCl2, finally add
Enter the pig whole blood after 2 mL constant temperature, start simultaneously at timing, the time of whole blood coagulation is 2.5 min.
Embodiment 3
A kind of preparation method of quick-acting haemostatic powder type looped fabric, the preparation method comprise the following steps：
6 mass parts chitosans are dissolved in 80 mass parts 4wt.% dilute acetic acid solutions by step 1, then add 3 mass parts urea
Chitosan spinning solution is prepared into 2 mass parts zinc acetates；
Step 2 adds 1 mass parts structure directing agent in 120 mass parts deionized waters, and 1.5 matter are added after stirring 14min
Part sodium hydroxide is measured, 5 mass parts absolute ethyl alcohols is added after stirring and dissolving, 1.5 mass parts tetraethoxysilances is then added dropwise and add
Heat to 85 DEG C and continue stir 16 h obtain colloidal sol；
Step 3 is filtered after colloidal sol prepared by step 2 is cooled to room temperature, washed, drying, then in 350 DEG C of roasting temperatures
5 h obtain mesoporous silicon oxide；
The mesoporous silicon oxide that step 4 takes 2 ~ 4 mass parts step 3 to prepare, which is added in the wt.% NaOH solutions of 66 mass parts 3, to be stirred
Mix uniformly；
Chitosan spinning solution prepared by step 1 is sprayed into step 4 through a diameter of 0.1mm ~ 1mm spinning heads and prepared by step 5
Stir after mixed liquor in make its solidification, 45 min are dried at a temperature of 77 DEG C in a tensioned state after stretching, washing,
Then spinned, spin the yarn come and be made into looped fabric by knitting machine.
Detection experiment is carried out to quick-acting haemostatic powder type looped fabric made from the present embodiment, the looped fabric of preparation is folded, cut,
By average piece weight 0.8g, area needed for hemostatic gauze is cut into, it is long：A width of 10:7 ratio, claims during cutting every 20min
Weight successively, it is found that deviation adjusts in time, specific test result is as follows：
1st, dissolubility detects：The quick-acting haemostatic powder type looped fabric 0.5g of the present invention, warm water 100mL is taken to be dissolved, solution is in nothing
Color or slightly yellow translucent sticky colloid, micro-strip opalescence, no insoluble fibre.
2nd, acid-base value detects：The quick-acting haemostatic powder type looped fabric 0.5g of the present invention is taken, after adding water 100mL to dissolve, pH is measured and exists
In the range of 6.0-8.0.
3rd, Sterility testing：Preparation process of the present invention strictly observes sterile working standard, up to specification after testing.
4th, anthemorrhagic performance is tested：Take 4 mL pigs whole bloods in advance in 25 DEG C of constant temperature water bath half an hour, first determination nature blood coagulation
Between, take 2 mL 0.2M CaCl2 Solution, the whole blood of 2 mL constant temperature is then added, it is 10 min to measure the nature clotting time.Then
Take the g of quick-acting haemostatic powder type looped fabric 0.5 of the present invention to add in 10 mL centrifuge tube, add 2 mL 0.2M CaCl2, finally add
Enter the pig whole blood after 2 mL constant temperature, start simultaneously at timing, the time of whole blood coagulation is 1.5 min.
Comparative example 1
With embodiment 3, difference is not add zinc acetate, and specific preparation process is as follows：
6 mass parts chitosans are dissolved in 80 mass parts 4wt.% dilute acetic acid solutions by step 1, then add 3 mass parts urea
It is prepared into chitosan spinning solution；
Step 2 adds 1 mass parts structure directing agent in 120 mass parts deionized waters, and 1.5 matter are added after stirring 14min
Part sodium hydroxide is measured, 5 mass parts absolute ethyl alcohols is added after stirring and dissolving, 1.5 mass parts tetraethoxysilances is then added dropwise and add
Heat to 85 DEG C and continue stir 16 h obtain colloidal sol；
Step 3 is filtered after colloidal sol prepared by step 2 is cooled to room temperature, washed, drying, then in 350 DEG C of roasting temperatures
5 h obtain mesoporous silicon oxide；
The mesoporous silicon oxide that step 4 takes 2 ~ 4 mass parts step 3 to prepare, which is added in the wt.% NaOH solutions of 66 mass parts 3, to be stirred
Mix uniformly；
Chitosan spinning solution prepared by step 1 is sprayed into step 4 through a diameter of 0.1mm ~ 1mm spinning heads and prepared by step 5
Stir after mixed liquor in make its solidification, 45 min are dried at a temperature of 77 DEG C in a tensioned state after stretching, washing,
Then spinned, spin the yarn come and be made into looped fabric by knitting machine.
Detection experiment is carried out to quick-acting haemostatic powder type looped fabric made from the present embodiment, the looped fabric of preparation is folded, cut,
By average piece weight 0.8g, area needed for hemostatic gauze is cut into, it is long：A width of 10:7 ratio, claims during cutting every 20min
Weight successively, it is found that deviation adjusts in time, specific test result is as follows：
1st, dissolubility detects：The quick-acting haemostatic powder type looped fabric 0.5g of the present invention, warm water 100mL is taken to be dissolved, solution is in nothing
Color or slightly yellow translucent sticky colloid, micro-strip opalescence, no insoluble fibre.
2nd, acid-base value detects：The quick-acting haemostatic powder type looped fabric 0.5g of the present invention is taken, after adding water 100mL to dissolve, pH is measured and exists
In the range of 6.0-8.0.
3rd, Sterility testing：Preparation process of the present invention strictly observes sterile working standard, up to specification after testing.
4th, anthemorrhagic performance is tested：Take 4 mL pigs whole bloods in advance in 25 DEG C of constant temperature water bath half an hour, first determination nature blood coagulation
Between, take 2 mL 0.2M CaCl2 Solution, the whole blood of 2 mL constant temperature is then added, it is 10 min to measure the nature clotting time.Then
Take the g of quick-acting haemostatic powder type looped fabric 0.5 of the present invention to add in 10 mL centrifuge tube, add 2 mL 0.2M CaCl2, finally add
Enter the pig whole blood after 2 mL constant temperature, start simultaneously at timing, the time of whole blood coagulation is 5.5 min.
Comparative example 2
With embodiment 3, difference is not add tetraethoxysilance, and specific preparation process is as follows：
6 mass parts chitosans are dissolved in 80 mass parts 4wt.% dilute acetic acid solutions by step 1, then add 3 mass parts urea
Chitosan spinning solution is prepared into 2 mass parts zinc acetates；
Step 2 adds 1 mass parts structure directing agent in 120 mass parts deionized waters, and 1.5 matter are added after stirring 14min
Measure part sodium hydroxide, add 5 mass parts absolute ethyl alcohols after stirring and dissolving, be then heated to 85 DEG C and continue to stir 16 h obtain it is molten
Glue；
Chitosan spinning solution prepared by step 1 is sprayed into step 2 through a diameter of 0.1mm ~ 1mm spinning heads and prepared by step 3
Stir after mixed liquor in make its solidification, 45 min are dried at a temperature of 77 DEG C in a tensioned state after stretching, washing,
Then spinned, spin the yarn come and be made into looped fabric by knitting machine.
Detection experiment is carried out to quick-acting haemostatic powder type looped fabric made from the present embodiment, the looped fabric of preparation is folded, cut,
By average piece weight 0.8g, area needed for hemostatic gauze is cut into, it is long：A width of 10:7 ratio, claims during cutting every 20min
Weight successively, it is found that deviation adjusts in time, specific test result is as follows：
1st, dissolubility detects：The quick-acting haemostatic powder type looped fabric 0.5g of the present invention, warm water 100mL is taken to be dissolved, solution is in nothing
Color or slightly yellow translucent sticky colloid, micro-strip opalescence, no insoluble fibre.
2nd, acid-base value detects：The quick-acting haemostatic powder type looped fabric 0.5g of the present invention is taken, after adding water 100mL to dissolve, pH is measured and exists
In the range of 6.0-8.0.
3rd, Sterility testing：Preparation process of the present invention strictly observes sterile working standard, up to specification after testing.
4th, anthemorrhagic performance is tested：Take 4 mL pigs whole bloods in advance in 25 DEG C of constant temperature water bath half an hour, first determination nature blood coagulation
Between, take 2 mL 0.2M CaCl2 Solution, the whole blood of 2 mL constant temperature is then added, it is 10 min to measure the nature clotting time.Then
Take the g of quick-acting haemostatic powder type looped fabric 0.5 of the present invention to add in 10 mL centrifuge tube, add 2 mL 0.2M CaCl2, finally add
Enter the pig whole blood after 2 mL constant temperature, start simultaneously at timing, the time of whole blood coagulation is 8 min.
Claims (7)
1. a kind of preparation method of quick-acting haemostatic powder type looped fabric, it is characterised in that the preparation method comprises the following steps：
5 ~ 10 mass parts chitosans are dissolved in 75 ~ 86 mass parts 2 ~ 5wt.% dilute acetic acid solutions by step 1, then add 2 ~ 5
Mass parts urea and 1 ~ 3 mass parts zinc acetate are prepared into chitosan spinning solution；
Step 2 adds 0.5 ~ 1 mass parts structure directing agent in 100 ~ 130 mass parts deionized waters, after stirring 10 ~ 15min
1 ~ 2 mass parts sodium hydroxide is added, 4 ~ 6 mass parts absolute ethyl alcohols is added after stirring and dissolving, 1 ~ 2 mass parts is then added dropwise
Tetraethoxysilance is heated to 80 ~ 90 DEG C and continues the h of stirring 15 ~ 18 to obtain colloidal sol；
Step 3 is filtered after colloidal sol prepared by step 2 is cooled to room temperature, washed, drying, then at a temperature of 300 ~ 420 DEG C
4 ~ 5.5 h of roasting obtain mesoporous silicon oxide；
It is molten that the mesoporous silicon oxide that step 4 takes 2 ~ 4 mass parts step 3 to prepare adds the wt.% NaOH of 60 ~ 75 mass parts 2 ~ 4
Stirred in liquid；
Chitosan spinning solution prepared by step 1 is sprayed into step 4 through a diameter of 0.1mm ~ 1mm spinning heads and prepared by step 5
Stir after mixed liquor in make its solidification, dry at a temperature of 75 ~ 78 DEG C 30 after stretching, washing in a tensioned state ~
60min, then spinned, spin the yarn come and be made into looped fabric by knitting machine.
A kind of 2. preparation method of quick-acting haemostatic powder type looped fabric according to claim 1, it is characterised in that the step 1
It is middle that 6 mass parts chitosans are dissolved in the wt.% dilute acetic acid solutions of 80 mass parts 4, then add 3 mass parts urea and 2 mass
Part zinc acetate is prepared into chitosan spinning solution.
A kind of 3. preparation method of quick-acting haemostatic powder type looped fabric according to claim 1, it is characterised in that the step 2
Middle structure directing agent is TPAOH.
A kind of 4. preparation method of quick-acting haemostatic powder type looped fabric according to claim 1, it is characterised in that the step 2
It is middle to add 1 mass parts structure directing agent in 120 mass parts deionized waters, add 1.5 mass parts hydrogen-oxygens after stirring 14 min
Change sodium, add 5 mass parts absolute ethyl alcohols after stirring and dissolving, 1.5 mass parts tetraethoxysilances are then added dropwise and are heated to 85 DEG C
And continue 16 h of stirring and obtain colloidal sol.
A kind of 5. preparation method of quick-acting haemostatic powder type looped fabric according to claim 1, it is characterised in that the step 3
In in 350 DEG C of h of roasting temperature 5 obtain mesoporous silicon oxide.
A kind of 6. preparation method of quick-acting haemostatic powder type looped fabric according to claim 1, it is characterised in that the step 4
In take 3 mass parts step 3 prepare mesoporous silicon oxide add the wt.% NaOH solutions of 66 mass parts 3 in stir.
A kind of 7. preparation method of quick-acting haemostatic powder type looped fabric according to claim 1, it is characterised in that the step 5
In at a temperature of 77 DEG C dry 45 min.
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Application publication date: 20180406 |