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CN1078474A - 一种制备取代的甾族二烯类化合物的改进方法 - Google Patents

一种制备取代的甾族二烯类化合物的改进方法 Download PDF

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Publication number
CN1078474A
CN1078474A CN 93102530 CN93102530A CN1078474A CN 1078474 A CN1078474 A CN 1078474A CN 93102530 CN93102530 CN 93102530 CN 93102530 A CN93102530 A CN 93102530A CN 1078474 A CN1078474 A CN 1078474A
Authority
CN
China
Prior art keywords
compound
formula
steroid
carboxylic acid
alkali
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN 93102530
Other languages
English (en)
Chinese (zh)
Inventor
N·H·贝恩
M·麦奎尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of CN1078474A publication Critical patent/CN1078474A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0066—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by a carbon atom forming part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN 93102530 1992-02-07 1993-02-06 一种制备取代的甾族二烯类化合物的改进方法 Pending CN1078474A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83227992A 1992-02-07 1992-02-07
US832,279 1992-02-07

Publications (1)

Publication Number Publication Date
CN1078474A true CN1078474A (zh) 1993-11-17

Family

ID=25261205

Family Applications (1)

Application Number Title Priority Date Filing Date
CN 93102530 Pending CN1078474A (zh) 1992-02-07 1993-02-06 一种制备取代的甾族二烯类化合物的改进方法

Country Status (13)

Country Link
EP (1) EP0626972A4 (fr)
JP (1) JPH07505618A (fr)
KR (1) KR950700320A (fr)
CN (1) CN1078474A (fr)
AU (1) AU3612893A (fr)
CA (1) CA2129347A1 (fr)
IL (1) IL104601A0 (fr)
MA (1) MA22787A1 (fr)
MX (1) MX9300677A (fr)
SI (1) SI9300067A (fr)
TW (1) TW241266B (fr)
WO (1) WO1993016098A1 (fr)
ZA (1) ZA93802B (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL104602A (en) * 1992-02-07 1997-07-13 Smithkline Beecham Corp Process for the preparation of 3-carbonylandrostadiene- 17-carboxamides and intermediates for this process
US5641765A (en) * 1992-11-18 1997-06-24 Smithkline Beecham Corporation 17-αand 17-βsubstituted acyl-3-carboxy-3,5-dienes and use in inhibiting 5-α-reductase
US5683995A (en) * 1992-11-18 1997-11-04 Smithkline Beecham Corporation 17 substituted acyl-3-carboxy 3,5-diene steroidals as α-reductase inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4946834A (en) * 1988-12-23 1990-08-07 Smithkline Beecham Corporation Phosphonic acid substituted steroids as steroid 5α-reductase inhibitors
US5032586A (en) * 1989-08-24 1991-07-16 Smithkline Beecham Corporation 7-keto or hydroxy 3,5-diene steroids as inhibitors of steroid 5-alpha reductase
US5091380A (en) * 1990-06-28 1992-02-25 Merck & Co., Inc. N-monosubstituted adamantyl/norbornanyl 17β-carbamides of 3-carboxy-androst-3,5-dienes as testosterone 5α-reductase inhibitors

Also Published As

Publication number Publication date
EP0626972A1 (fr) 1994-12-07
SI9300067A (en) 1993-09-30
TW241266B (fr) 1995-02-21
AU3612893A (en) 1993-09-03
KR950700320A (ko) 1995-01-16
CA2129347A1 (fr) 1993-08-19
ZA93802B (en) 1993-11-05
IL104601A0 (en) 1993-07-08
MX9300677A (es) 1994-07-29
JPH07505618A (ja) 1995-06-22
EP0626972A4 (en) 1995-01-04
WO1993016098A1 (fr) 1993-08-19
MA22787A1 (fr) 1993-10-01

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C01 Deemed withdrawal of patent application (patent law 1993)
WD01 Invention patent application deemed withdrawn after publication