CN107805376A - A kind of medical lactic acid composite material and the disposable syringe of preparation - Google Patents
A kind of medical lactic acid composite material and the disposable syringe of preparation Download PDFInfo
- Publication number
- CN107805376A CN107805376A CN201711075868.8A CN201711075868A CN107805376A CN 107805376 A CN107805376 A CN 107805376A CN 201711075868 A CN201711075868 A CN 201711075868A CN 107805376 A CN107805376 A CN 107805376A
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- Prior art keywords
- copper
- pla
- composite
- toughener
- medical
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/30—Sulfur-, selenium- or tellurium-containing compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
- C08L67/04—Polyesters derived from hydroxycarboxylic acids, e.g. lactones
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/30—Sulfur-, selenium- or tellurium-containing compounds
- C08K2003/3045—Sulfates
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K2201/00—Specific properties of additives
- C08K2201/018—Additives for biodegradable polymeric composition
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2201/00—Properties
- C08L2201/06—Biodegradable
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2203/00—Applications
- C08L2203/02—Applications for biomedical use
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Abstract
The present invention relates to a kind of medical degradable polylactic acid composite material for injector of blending and modifying, and the syringe prepared.It is specifically a kind of medical degradable composite material, it contains PLA（PLA), toughener, wherein every 100 parts by weight PLA（PLA 0 50 parts of toughener) is contained.The whole blend components of the present invention are medical grade non-toxic product, its synthon and corresponding polymer are to human body totally nontoxic, water and carbon dioxide can be degraded to automatically in 46 months under composting conditionses, small molecule plasticizer is free of in blending resin, such compound will not occur and separate out, pollute decoction and enter the danger of human body.It can be as the PP Pipe Compound of disposable degradable syringe, for preparing disposable degradable syringe.Material property in terms of antibacterial, degraded is substantially better than pure polylactic acid raw material.Inventive formulation rationally, it is stable performance, free from environmental pollution, can produce in enormous quantities in cleaning shop.
Description
Technical field
The present invention relates to a kind of high polymer material, the medical degradable syringe of specifically a kind of blending and modifying, which is used, to be gathered
Lactic acid composite, and the syringe prepared.
Background technology
China medical macromolecular materials product development starts late, just develop the 1970s disposable transfusion device,
The product such as syringe and plastic blood bag, at present disposable syringe base material generally given up using material, this kind of syringe such as polypropylene
It can not voluntarily be degraded after abandoning, pollute environment, endanger the health of people.Common centralized burning destroys method, not only can not be real
Existing resources circulation recycles, and can aggravate environmental pollution.Driven by interests, discarded syringe is illegal sharp again by criminal
With the medical hidden danger such as cross-infection can be produced.So the disposable medical infusion apparatus of exploitation fully biodegradable is carved and not allowed
It is slow.
The fusing point of PLA is higher（175 °C), its physical property is between PET (poly terephthalic acid class plastics）And PA-6
(nylon plastic(s)）Between, crystallinity is big, excellent transparency, has good solvent resistance, protection against the tide, grease resistance, gas permeability, also has
Certain fungus resistance, anti-flammability and ultraviolet-resistent property.PLA（PLA) there is excellent biocompatibility, biodegradability, gather
Lactic acid also has preferable processing characteristics, can be suitably used for the processing methods such as traditional extrusion, injection, blowing, poly-lactic acid material
Can and processing characteristics Shortcomings, it is mainly more crisp, and existing poly-lactic acid material is significantly improved sky in terms of sterilization
Between.
The content of the invention
The technical problems to be solved by the invention are to overcome above-mentioned the deficiencies in the prior art, there is provided one kind formula is reasonable, property
Can be stable, bactericidal property is good, and degradation speed is fast, the disposable syringe that can produce in enormous quantities in cleaning shop with it is medical can
Degrading composite, and the syringe prepared.
The present invention solves the technical scheme that above-mentioned technical problem uses：A kind of medical degradable composite material, its feature
It is：Contain PLA（PLA), optional toughener, wherein every 100 parts by weight PLA（PLA toughener 0-50 parts) are contained.
Toughener of the present invention is thermoplastic elastomer (TPE), can be thermoplastic polyurethane（) or phenylethylene thermoplastic TPU
Property elastomer (SEBS or SBS).
Further, copper is contained in described degradable composite material, on the basis of the weight of composite, copper coin
Cellulose content is 50ppm-10000ppm.Preferably, copper coin cellulose content is 100-5000ppm, is more highly preferred to, and copper coin cellulose content is
200-1000ppm.In one of embodiment, copper coin cellulose content is 100ppm, and in one embodiment in addition, copper contains
Measure as 200ppm, in one embodiment in addition, copper coin cellulose content is 300ppm.Secondly, copper coin cellulose content can also be
400ppm、500ppm、600ppm、700ppm、800ppm、900ppm、1000ppm。
Described copper is provided by the compound of cupric, optionally there is copper sulphate, basic copper sulfate, copper oxychloride, hydrogen
Cupric oxide, copper acetate, copper 8-hydroxyquinolinate, copper rosinate, amino acid copper, Thiodiazole-copper, network ammonia copper etc..
Copper coin fungicide rely primarily on-SH in release copper ion and fungi vivo protein ,-NH3 ,-COOH, with
And the group such as-OH works, reach and kill germ effect.Wherein ,-SH is represented as sulfydryl, and-NH3 is represented as amino and nitrogen ,-
COOH represents acid;- OH represents hydroxyl and alkali.The addition of copper can cause the composite to have excellent antibacterial effect,
Copper coin fungicide can prevent and treat fungal disease, and can preventing and treating bacterial disease.But moreover, we have surprisingly found that,
The addition of copper can also improve the degradation property of material, it is possible to reduce about 1/3 degradation time, this is for reducing discarded object
Accumulation be highly beneficial.
In addition, the present invention also provides a kind of disposable medical syringe, it is prepared by above-mentioned degradable material.
The method that syringe is prepared for degradable material is not limited, and method generally in the art may be selected, such as note
Shaping, extrusion molding etc. are penetrated, is preferably injection moulded.
Beneficial effects of the present invention：
The present invention selects the PLA of proper ratio（PLA), toughener, and the copper for adding appropriate level is prepared and can dropped
Solve composite.Toughener thermoplasticity elastomer（TPU or SEBS or SBS) its crazing-shear band toughening mechanism is utilized, improve
The toughness of material.The addition of copper can improve the antibiotic property of composite, and be found surprisingly that and can improve degradation property.
The composite processing process is simple, practical, can be applied to manufacture disposable degradable syringe.
The present invention is with PLA（PLA) be material of main part medical degradable composite material, the composite it is main
Feature is：Whole blend components are medical grade non-toxic product, its synthon and corresponding polymer to human body totally nontoxic,
Water and carbon dioxide can be degraded to automatically in 4-6 under composting conditionses months, small molecule plasticizer is free of in blending resin, will not
Such compound occurs and separates out, pollute decoction and enter the danger of human body.It can be as disposable degradable syringe
PP Pipe Compound, for preparing disposable degradable syringe.It is fast that disposable syringe voluntarily destroys speed, solves useless modeling
The pollution problem of material, disposable syringe is set to be really achieved disposable purpose.The material is in terms of antibacterial, degraded
Property is substantially better than pure polylactic acid raw material.Inventive formulation rationally, it is stable performance, free from environmental pollution, being can be large quantities of in cleaning shop
Amount production, the PP Pipe Compound suitable for making a one-time use only degradable syringe.
Embodiment
With reference to embodiment, the invention will be further described：
A kind of medical degradable composite material of the present invention, a kind of medical degradable composite material, it is characterized in that：Contain PLA
（PLA), optional toughener, wherein every 100 parts by weight PLA（PLA toughener 0-50 parts) are contained.
Toughener of the present invention is thermoplastic elastomer (TPE), can be thermoplastic polyurethane（) or phenylethylene thermoplastic TPU
Property elastomer (SEBS or SBS).
Further, copper is contained in described degradable composite material, on the basis of the weight of composite, copper coin
Cellulose content is 50ppm-10000ppm.Preferably, copper coin cellulose content is 100-5000ppm, is more highly preferred to, and copper coin cellulose content is
200-1000ppm.In one of embodiment, copper coin cellulose content is 100ppm, and in one embodiment in addition, copper contains
Measure as 200ppm, in one embodiment in addition, copper coin cellulose content is 300ppm.Secondly, copper coin cellulose content can also be
400ppm、500ppm、600ppm、700ppm、800ppm、900ppm、1000ppm。
Described copper is provided by the compound of cupric, optionally there is copper sulphate, basic copper sulfate, copper oxychloride, hydrogen
Cupric oxide, copper acetate, copper 8-hydroxyquinolinate, copper rosinate, amino acid copper, Thiodiazole-copper, network ammonia copper etc..
Various embodiments of the present invention are formulated various raw materials and are well mixed, and are then granulated in double-screw extruding pelletizing machine, will be upper
State premix to be transported in double screw extruder, obtain composite, and test respective performances index.Then in 100,000 grades of purifications
Injection molding is carried out on injection machine in workshop, obtains product.Resulting product uniform color, outward appearance are good.
Embodiment 1：
100 parts of PLA is weighed in proportion, adds copper sulphate so that copper coin cellulose content is 200ppm, is total to using high speed agitator
Mixed 5min, mixed material is added in double-screw extruding pelletizing machine and is granulated, and is cooled down, pelletizing, obtained material is carried out testing it
Mechanical property, anti-microbial property and degradation property.
Embodiment 2：
100 parts of PLA, 10 parts of SEBS are weighed in proportion, add basic copper sulfate so that copper coin cellulose content is 300ppm, is made
5min is blended with high speed agitator, mixed material is added in double-screw extruding pelletizing machine and is granulated, cools down, pelletizing, to what is obtained
Material carries out testing its mechanical property, anti-microbial property and degradation property.
Embodiment 3：
100 parts of PLA, 20 parts of SEBS are weighed in proportion, add copper acetate so that copper coin cellulose content is 400ppm, uses height
5min is blended in fast agitator, and mixed material is added in double-screw extruding pelletizing machine and is granulated, and is cooled down, pelletizing, to obtained material
Carry out testing its mechanical property, anti-microbial property and degradation property.
Embodiment 4：
100 parts of PLA, 30 parts of SEBS are weighed in proportion, add copper 8-hydroxyquinolinate so that copper coin cellulose content is 500ppm, uses height
5min is blended in fast agitator, and mixed material is added in double-screw extruding pelletizing machine and is granulated, and is cooled down, pelletizing, to obtained material
Carry out testing its mechanical property, anti-microbial property and degradation property.
Embodiment 5：
100 parts of PLA, 40 parts of SEBS are weighed in proportion, adds copper rosinate so that copper coin cellulose content is 600ppm, is used
5min is blended in high speed agitator, and mixed material is added in double-screw extruding pelletizing machine and is granulated, and is cooled down, pelletizing, to obtained material
Material carries out testing its mechanical property, anti-microbial property and degradation property.
Embodiment 6：
100 parts of PLA, 50 parts of SEBS are weighed in proportion, adds amino acid copper so that copper coin cellulose content is 700ppm, is used
5min is blended in high speed agitator, and mixed material is added in double-screw extruding pelletizing machine and is granulated, and is cooled down, pelletizing, to obtained material
Material carries out testing its mechanical property, anti-microbial property and degradation property.
Comparative example 1：
100 parts of PLA, 20 parts of SEBS are weighed in proportion, 5min is blended using high speed agitator, and mixed material is added into double spiral shells
It is granulated in bar extruding granulator, cools down, pelletizing, obtained material is carried out testing its mechanical property, anti-microbial property and degradability
Energy.
Test the results are shown in Table 1
| Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 | Embodiment 6 | Comparative example 1 | |
| Elongation at break/% | 2.5 | 106 | 164 | 196 | 223 | 268 | 164 |
| Tensile strength/MPa | 50 | 44 | 39 | 32 | 28 | 24 | 39 |
| Anti-microbial property | 90% | 91% | 93% | 96% | 97% | 97% | 40% |
| Degradation property*/ day | 70 | 67 | 60 | 58 | 57 | 56 | 87 |
* the time therein is the time of degraded half weight.
It can be seen that the addition of copper effectively improves the anti-microbial property of lactic acid composite material.Moreover, copper
Add improves the degradation property of material simultaneously, and degradation time about shortens 1/3 or so.
The explanation of above example is only intended to help the core concept for understanding the present invention.It should be pointed out that for this area
Those of ordinary skill for, under the premise without departing from the principles of the invention, can also to the present invention carry out it is some improvement and repair
Decorations, but these are improved and modification is also fallen into the range of the claims in the present invention are claimed.
Claims (10)
1. a kind of medical degradable composite material, it is characterized in that：Contain PLA（PLA) and optional toughener, wherein every 100
Parts by weight PLA（PLA toughener 0-50 parts) are contained.
2. composite according to claim 1, described toughener is thermoplastic elastomer (TPE).
3. composite according to claim 1, described toughener can be thermoplastic polyurethane（) or styrene TPU
Analog thermoplastic elastomer (SEBS or SBS).
4. composite according to claim 1, contain copper in described degradable composite material.
5. composite according to claim 1, on the basis of the weight of composite, described copper coin cellulose content is
50ppm-10000ppm。
6. composite according to claim 1, on the basis of the weight of composite, described copper coin cellulose content is
100-5000ppm。
7. composite according to claim 1, on the basis of the weight of composite, described copper coin cellulose content is
200-1000ppm。
8. according to the composite described in claim any one of 5-7, described copper is provided by the compound of cupric.
9. composite according to claim 8, described copper-containing compound optionally have copper sulphate, basic copper sulfate,
Copper oxychloride, Kocide SD, copper acetate, copper 8-hydroxyquinolinate, copper rosinate, amino acid copper, Thiodiazole-copper, network ammonia copper etc..
10. a kind of disposable medical syringe, it is prepared as the composite described in claim any one of 1-9.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711075868.8A CN107805376A (en) | 2017-11-06 | 2017-11-06 | A kind of medical lactic acid composite material and the disposable syringe of preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711075868.8A CN107805376A (en) | 2017-11-06 | 2017-11-06 | A kind of medical lactic acid composite material and the disposable syringe of preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107805376A true CN107805376A (en) | 2018-03-16 |
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ID=61582841
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711075868.8A Pending CN107805376A (en) | 2017-11-06 | 2017-11-06 | A kind of medical lactic acid composite material and the disposable syringe of preparation |
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| CN (1) | CN107805376A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109666282A (en) * | 2019-01-15 | 2019-04-23 | 南通大学 | A kind of antibacterial degradable lactic acid composite material and its disposable syringe of preparation |
| CN109735075A (en) * | 2019-01-15 | 2019-05-10 | 南通大学 | A kind of antibacterial degradable founds the syringe of structure lactic acid composite material and its preparation |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101519527A (en) * | 2009-03-24 | 2009-09-02 | 山东威高集团医用高分子制品股份有限公司 | Medical degradable composite material |
-
2017
- 2017-11-06 CN CN201711075868.8A patent/CN107805376A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101519527A (en) * | 2009-03-24 | 2009-09-02 | 山东威高集团医用高分子制品股份有限公司 | Medical degradable composite material |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109666282A (en) * | 2019-01-15 | 2019-04-23 | 南通大学 | A kind of antibacterial degradable lactic acid composite material and its disposable syringe of preparation |
| CN109735075A (en) * | 2019-01-15 | 2019-05-10 | 南通大学 | A kind of antibacterial degradable founds the syringe of structure lactic acid composite material and its preparation |
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Application publication date: 20180316 |
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