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CN107787373B - 法尼基转移酶抑制剂在制备用于治疗癌症的药物中的用途 - Google Patents

法尼基转移酶抑制剂在制备用于治疗癌症的药物中的用途 Download PDF

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CN107787373B
CN107787373B CN201680031764.4A CN201680031764A CN107787373B CN 107787373 B CN107787373 B CN 107787373B CN 201680031764 A CN201680031764 A CN 201680031764A CN 107787373 B CN107787373 B CN 107787373B
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CN107787373A (zh
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安东尼奥·瓜尔贝托
凯瑟琳·罗斯·肖尔兹
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Kura Oncology Inc
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Kura Oncology Inc
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Priority to CN202010013228.XA priority patent/CN111214658B/zh
Priority to CN201810463246.0A priority patent/CN108371711A/zh
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    • A—HUMAN NECESSITIES
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A—HUMAN NECESSITIES
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
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CN201680031764.4A 2015-08-17 2016-08-16 法尼基转移酶抑制剂在制备用于治疗癌症的药物中的用途 Active CN107787373B (zh)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CN202111299593.2A CN114306604A (zh) 2015-08-17 2016-08-16 法尼基转移酶抑制剂在制备用于治疗癌症的药物中的用途
CN202111313741.1A CN114107497A (zh) 2015-08-17 2016-08-16 法尼基转移酶抑制剂在制备用于治疗癌症的药物中的用途
CN202010013228.XA CN111214658B (zh) 2015-08-17 2016-08-16 使用法尼基转移酶抑制剂治疗癌症患者的方法
CN201810463246.0A CN108371711A (zh) 2015-08-17 2016-08-16 使用法尼基转移酶抑制剂治疗癌症患者的方法

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201562206194P 2015-08-17 2015-08-17
US62/206,194 2015-08-17
US201562218927P 2015-09-15 2015-09-15
US62/218,927 2015-09-15
US201562241019P 2015-10-13 2015-10-13
US62/241,019 2015-10-13
US201662310582P 2016-03-18 2016-03-18
US62/310,582 2016-03-18
US201662372662P 2016-08-09 2016-08-09
US62/372,662 2016-08-09
PCT/US2016/047140 WO2017031101A1 (en) 2015-08-17 2016-08-16 Methods of treating cancer patients with farnesyl transferase inhibitors

Related Child Applications (4)

Application Number Title Priority Date Filing Date
CN202010013228.XA Division CN111214658B (zh) 2015-08-17 2016-08-16 使用法尼基转移酶抑制剂治疗癌症患者的方法
CN201810463246.0A Division CN108371711A (zh) 2015-08-17 2016-08-16 使用法尼基转移酶抑制剂治疗癌症患者的方法
CN202111299593.2A Division CN114306604A (zh) 2015-08-17 2016-08-16 法尼基转移酶抑制剂在制备用于治疗癌症的药物中的用途
CN202111313741.1A Division CN114107497A (zh) 2015-08-17 2016-08-16 法尼基转移酶抑制剂在制备用于治疗癌症的药物中的用途

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CN107787373A CN107787373A (zh) 2018-03-09
CN107787373B true CN107787373B (zh) 2021-11-26

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CN201680031764.4A Active CN107787373B (zh) 2015-08-17 2016-08-16 法尼基转移酶抑制剂在制备用于治疗癌症的药物中的用途
CN202111299593.2A Pending CN114306604A (zh) 2015-08-17 2016-08-16 法尼基转移酶抑制剂在制备用于治疗癌症的药物中的用途
CN201810463246.0A Pending CN108371711A (zh) 2015-08-17 2016-08-16 使用法尼基转移酶抑制剂治疗癌症患者的方法
CN202111313741.1A Pending CN114107497A (zh) 2015-08-17 2016-08-16 法尼基转移酶抑制剂在制备用于治疗癌症的药物中的用途
CN202010013228.XA Active CN111214658B (zh) 2015-08-17 2016-08-16 使用法尼基转移酶抑制剂治疗癌症患者的方法

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CN202111299593.2A Pending CN114306604A (zh) 2015-08-17 2016-08-16 法尼基转移酶抑制剂在制备用于治疗癌症的药物中的用途
CN201810463246.0A Pending CN108371711A (zh) 2015-08-17 2016-08-16 使用法尼基转移酶抑制剂治疗癌症患者的方法
CN202111313741.1A Pending CN114107497A (zh) 2015-08-17 2016-08-16 法尼基转移酶抑制剂在制备用于治疗癌症的药物中的用途
CN202010013228.XA Active CN111214658B (zh) 2015-08-17 2016-08-16 使用法尼基转移酶抑制剂治疗癌症患者的方法

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US (7) US10471055B2 (el)
EP (4) EP3277842B9 (el)
JP (4) JP6630742B2 (el)
KR (4) KR102246710B1 (el)
CN (5) CN107787373B (el)
AU (3) AU2016308564B2 (el)
CA (1) CA2985123C (el)
CY (3) CY1122037T1 (el)
DK (3) DK3385395T3 (el)
EA (1) EA201890512A1 (el)
ES (3) ES2741782T3 (el)
HK (1) HK1254087A1 (el)
HR (3) HRP20211976T1 (el)
HU (3) HUE044698T2 (el)
IL (1) IL257547B (el)
LT (3) LT3385395T (el)
MX (1) MX2018001769A (el)
MY (1) MY195484A (el)
NZ (1) NZ736853A (el)
PH (1) PH12018500322A1 (el)
PL (3) PL3640345T3 (el)
PT (3) PT3385395T (el)
RS (3) RS60149B9 (el)
SG (1) SG10202101740QA (el)
SI (3) SI3640345T1 (el)
TW (3) TWI710642B (el)
WO (1) WO2017031101A1 (el)
ZA (2) ZA201801047B (el)

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HUE053927T2 (hu) * 2016-11-03 2021-07-28 Kura Oncology Inc Farneziltranszferáz inhibitorok rák kezelésében történõ alkalmazásra
US10806730B2 (en) 2017-08-07 2020-10-20 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors
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CA3117968A1 (en) * 2018-11-01 2020-05-07 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors
KR20210106513A (ko) * 2018-12-21 2021-08-30 쿠라 온콜로지, 인크. 편평 세포 암종을 위한 요법
CN110656172A (zh) * 2019-01-14 2020-01-07 南方医科大学珠江医院 一种预测小细胞肺癌对ep化疗方案敏感性的分子标志物及试剂盒
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EP3942097A4 (en) * 2019-03-22 2024-03-27 The Regents of the University of California CHMP2A AS A REGULATOR OF NATURAL KILLER CELL-MEDIATED ACTIVITY
CA3134825A1 (en) * 2019-03-29 2020-10-08 Kura Oncology, Inc. Methods of treating squamous cell carcinomas with farnesyltransferase inhibitors
CN110241461A (zh) * 2019-06-24 2019-09-17 厦门大学 一种构建人nk细胞免疫球蛋白样受体文库的多重pcr引物和方法
CN111097039B (zh) * 2020-01-16 2020-11-06 南京医科大学 Ras相关蛋白2的制药用途
CN111088349B (zh) * 2020-02-14 2023-04-28 深圳市宝安区妇幼保健院 Kir3dl1基因分型引物组及其应用
JP2023524592A (ja) * 2020-05-08 2023-06-12 カーディフ・オンコロジー・インコーポレイテッド Ｋｒａｓ変異をモニタニングする方法
CN111863126B (zh) * 2020-05-28 2024-03-26 上海市生物医药技术研究院 构建结直肠肿瘤状态评估模型的方法及应用
EP4426303A1 (en) * 2021-11-02 2024-09-11 Semmelweis Egyetem Farnesyl-transferase inhibitors and kras inhibitors for treating kras mutant cancers
CN114045339B (zh) * 2021-11-05 2022-06-28 山东第一医科大学附属省立医院(山东省立医院) 铁死亡相关基因在弥漫大b细胞淋巴瘤预后评估中的应用
WO2023242104A1 (en) * 2022-06-13 2023-12-21 KHR Biotec GmbH Diaminoacridine derivatives as inhibitors of ras
WO2023242097A1 (en) * 2022-06-13 2023-12-21 KHR Biotec GmbH Mitoxanthrone derivatives as ras inhibitors
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