CN107556717A - A kind of poly (lactic acid) composition - Google Patents
A kind of poly (lactic acid) composition Download PDFInfo
- Publication number
- CN107556717A CN107556717A CN201710922659.6A CN201710922659A CN107556717A CN 107556717 A CN107556717 A CN 107556717A CN 201710922659 A CN201710922659 A CN 201710922659A CN 107556717 A CN107556717 A CN 107556717A
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- Prior art keywords
- poly
- lactic acid
- composition
- pla
- chitosan
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- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a kind of poly (lactic acid) composition, and comprising PLA and chitosan, PLA is 1 with chitosan mass ratio:0.1‑0.3.Poly (lactic acid) composition prepared by the present invention can be used for biomedicine field.
Description
Technical field
The present invention relates to a kind of composition, more particularly to a kind of poly (lactic acid) composition.
Background technology
PLA acetate multipolymer is by two kinds of monomers -- and lactic acid and acetic acid are polymerized at random, are a kind of degradable functions
Macromolecular organic compound, there is the performance of good biocompatibility, nontoxic, good encystation and film forming, be widely used
In pharmacy, medical engineering material and modernization industry field.
Chitosan has the premium properties such as biocompatibility, blood compatibility, security, microbic resolvability each by each row
Industry extensive concern, in medicine, food, chemical industry, cosmetics, water process, METAL EXTRACTION and recovery, biochemistry and biomedical engineering etc.
The application study of numerous areas achieves major progress.
The content of the invention
Goal of the invention：The invention provides poly (lactic acid) composition, can be used for biomedicine field, as hydrophobic drug
Carrier.
Technical scheme：A kind of poly (lactic acid) composition of the present invention, comprising PLA and chitosan, PLA and chitosan
Mass ratio is 1:0.15-0.3.
The PLA is 1 with chitosan mass ratio:0.2.
The polylactic acid molecule amount is 10000-15000KDa.The chitosan molecule amount is 30000-50000KDa.
The composition also includes surfactant.
The content of surfactant is 10-15% in the composition.
The surfactant is selected from alkylammonium salt form, amino alcohol fatty acid derivatives type, polyamines derivative of fatty acid type
With the one or more in imidazoline type.
The preparation method of above-mentioned poly (lactic acid) composition, comprises the following steps：(1) it is 9-10 PLA to be dissolved in into pH, temperature
In 90-95 DEG C of the aqueous solution, to add surfactant, stirring；(2) by chitosan in the pH temperature for being 2-3 be 50-60
DEG C the aqueous solution in, be completely dissolved；(3) solution in step (1) and step (2) is mixed, stirred, cooling, obtain finished product.
The finished product of above-mentioned gained is further processed, adds lyophobic dust curcumin, by high speed homogenization, rotating speed is
5000-7000 turns/min, homogenizing time 30-60min, and the mixed solution of gained is stable uniform system.
Beneficial effect：Poly (lactic acid) composition prepared by the present invention can be as the carrier of various hydrophobic material, further
Ground can prepare a variety of formulations, and application field is extensive, solve the shortcomings that different lyophobic dusts needs to configure different systems.
Embodiment
First, sample preparation
Embodiment 1：It is 9 that 100g PLAs will be dissolved in into pH, and temperature is in 90 DEG C of the aqueous solution, then adds 100g alkyl
It is 3 that 15g chitosans are dissolved in pH by ammonium salt type surfactant, and temperature is in 50 DEG C of the aqueous solution, after being completely dissolved, with water constant volume
To 1L, 3g curcumins, the homogeneous 60min under the conditions of 7000 turns/min are then added.
Embodiment 2：It is 9 that 50g PLAs will be dissolved in into pH, and temperature is in 90 DEG C of the aqueous solution, then adds 120g polyamines
15g chitosans are dissolved in pH for 3 by derivative of fatty acid type surfactant, and temperature is in 50 DEG C of the aqueous solution, after being completely dissolved,
1L is settled to water, then adds 3g curcumins, the homogeneous 60min under the conditions of 7000 turns/min.
Embodiment 3：It is 9 that 100g PLAs will be dissolved in into pH, and temperature is in 90 DEG C of the aqueous solution, then adds 150g amino
It is 3 that 20g chitosans are dissolved in pH by polyol fatty acid derivative type surfactant, and temperature is in 50 DEG C of the aqueous solution, is completely dissolved
Afterwards, 1L is settled to water, then adds 3g curcumins, the homogeneous 60min under the conditions of 7000 turns/min.
2nd, result determines
With Malvern ParticleSizer determination sample particle diameter, after sample determines particle diameter, it is positioned in 40 DEG C of insulating boxs, determination sample
Stability, see whether to be layered, as a result see the table below 1.
The sample measurement result of table 1
| Sample | Particle diameter (nm) | Period of storage (d) |
| Embodiment 1 | 500 | More than 180d has no layering |
| Embodiment 2 | 561 | More than 180d has no layering |
| Embodiment 3 | 543 | More than 180d has no layering |
Claims (5)
1. a kind of poly (lactic acid) composition, it is characterised in that comprising PLA and chitosan, PLA is 1 with chitosan mass ratio:
0.15-0.3。
2. poly (lactic acid) composition according to claim 1, it is characterised in that the PLA is 1 with chitosan mass ratio:
0.2。
3. poly (lactic acid) composition according to claim 1, it is characterised in that the composition also includes surfactant.
4. poly (lactic acid) composition according to claim 3, it is characterised in that the content of surfactant is in the composition
10-15%.
5. poly (lactic acid) composition according to claim 3, it is characterised in that the surfactant is selected from alkylammonium salt form, ammonia
One or more in base polyol fatty acid derivative type, polyamines derivative of fatty acid type and imidazoline type.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710922659.6A CN107556717A (en) | 2017-09-30 | 2017-09-30 | A kind of poly (lactic acid) composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710922659.6A CN107556717A (en) | 2017-09-30 | 2017-09-30 | A kind of poly (lactic acid) composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107556717A true CN107556717A (en) | 2018-01-09 |
Family
ID=60983892
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710922659.6A Pending CN107556717A (en) | 2017-09-30 | 2017-09-30 | A kind of poly (lactic acid) composition |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107556717A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101829355A (en) * | 2010-04-07 | 2010-09-15 | 北京航空航天大学 | Hydrophilic extra-cellular matrix glycan/ hydrophobic aliphatic polyester composite material and preparation method thereof |
| CN102421483A (en) * | 2009-03-11 | 2012-04-18 | 莱雅公司 | Cosmetic composition comprising a dye, said dye and cosmetic treatment method |
| CN102768481A (en) * | 2011-05-02 | 2012-11-07 | 株式会社理光 | Toner for electrophotography, developer, and image forming apparatus |
| CN104321051A (en) * | 2012-03-30 | 2015-01-28 | 加泰罗尼亚理工大学 | Nonwoven membrane as a drug delivery system |
-
2017
- 2017-09-30 CN CN201710922659.6A patent/CN107556717A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102421483A (en) * | 2009-03-11 | 2012-04-18 | 莱雅公司 | Cosmetic composition comprising a dye, said dye and cosmetic treatment method |
| CN101829355A (en) * | 2010-04-07 | 2010-09-15 | 北京航空航天大学 | Hydrophilic extra-cellular matrix glycan/ hydrophobic aliphatic polyester composite material and preparation method thereof |
| CN102768481A (en) * | 2011-05-02 | 2012-11-07 | 株式会社理光 | Toner for electrophotography, developer, and image forming apparatus |
| CN104321051A (en) * | 2012-03-30 | 2015-01-28 | 加泰罗尼亚理工大学 | Nonwoven membrane as a drug delivery system |
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| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180109 |
|
| RJ01 | Rejection of invention patent application after publication |