CN107522735A - In the method for solvent method production low viscosity phospholipid prod - Google Patents
In the method for solvent method production low viscosity phospholipid prod Download PDFInfo
- Publication number
- CN107522735A CN107522735A CN201710861857.6A CN201710861857A CN107522735A CN 107522735 A CN107522735 A CN 107522735A CN 201710861857 A CN201710861857 A CN 201710861857A CN 107522735 A CN107522735 A CN 107522735A
- Authority
- CN
- China
- Prior art keywords
- low viscosity
- maintained
- phospholipid prod
- isopropanol
- phospholipid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims abstract description 20
- 150000003904 phospholipids Chemical class 0.000 title claims abstract description 18
- 239000002904 solvent Substances 0.000 title claims abstract description 9
- 238000004519 manufacturing process Methods 0.000 title description 5
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims abstract description 28
- 239000006228 supernatant Substances 0.000 claims abstract description 12
- 238000003756 stirring Methods 0.000 claims abstract description 10
- 239000012535 impurity Substances 0.000 claims abstract description 7
- 238000010438 heat treatment Methods 0.000 claims abstract description 5
- 238000011084 recovery Methods 0.000 claims abstract description 5
- 239000000047 product Substances 0.000 abstract description 13
- 239000004480 active ingredient Substances 0.000 abstract description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical compound O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 description 3
- 229930186217 Glycolipid Natural products 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 2
- 235000010469 Glycine max Nutrition 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000010985 leather Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/10—Phosphatides, e.g. lecithin
- C07F9/103—Extraction or purification by physical or chemical treatment of natural phosphatides; Preparation of compositions containing phosphatides of unknown structure
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
Abstract
The invention provides a kind of method that low viscosity phospholipid prod is produced with solvent method, products obtained therefrom viscosity is relatively low, and the active ingredient in product will not reduce.It comprises the following steps：A, in mass, according to 1:2.5 ratio takes concentrated phosphatide, isopropanol input container, and temperature is maintained at 60 ± 2 DEG C, stirs 1h；B, after stirring terminates, vessel temp is maintained at 55 ~ 60 DEG C, stands 2h；C, supernatant is extracted, filters off the removal of impurity, the isopropanol in heating recovery supernatant, obtains low viscosity phospholipid prod.
Description
Technical field
The present invention relates to the production method of phospholipid prod, and in particular to a kind of production method of low viscosity phospholipid prod.
Background technology
Common concentrated phosphatide product viscosity is 8000 ~ 1000 or so, by going after the removal of impurity viscosity 5000 ~ 6000,
Because mobility can preferably be widely used in the industries such as food, leather chemical industry；But because its viscosity is unable to reach health products
The viscosity of capsule（Less than 2000）, it is difficult to operate during pelleting.
By the component analysis in laboratory, it is found that the viscosity height of phosphatide is primarily due to wherein contain substantial amounts of glycolipid（Account for
The 15 ~ 18% of content of phospholipid）, common impurity-removing method can not remove glycolipid；The diluents such as addition soybean oil can make having for product again
Imitate composition（Phosphatidyl choline）Reduce.
The Chinese invention patent application of Application No. 201010103156.4 discloses a kind of edible soybean transparent concentration phosphorus
The production method of fat, can be as the basis original of the present invention according to its method products obtained therefrom or kin concentrated phosphatide
Material.
The content of the invention
The technical problems to be solved by the invention are to provide a kind of method that low viscosity phospholipid prod is produced with solvent method,
Products obtained therefrom viscosity is relatively low, and the active ingredient in product will not reduce.
In order to solve the above technical problems, the method that low viscosity phospholipid prod is produced with solvent method of the present invention, including it is following
Step：
A, in mass, according to 1:2.5 ratio takes concentrated phosphatide, isopropanol input container, and temperature is maintained at 60 ± 2 DEG C, stirred
Mix 1h；
B, after stirring terminates, vessel temp is maintained at 55 ~ 60 DEG C, stands 2h；
C, supernatant is extracted, filters off the removal of impurity, the isopropanol in heating recovery supernatant, reaction temperature is maintained at 85 ~ 87 DEG C,
Obtain low viscosity phospholipid prod.
In described step A, 60 DEG C of reaction temperature；In described step B, 55 DEG C of reaction temperature.
In described step C, reaction temperature is maintained at 85 ~ 87 DEG C.The isopropanol that step C is reclaimed can be used as next batch
Reaction is applied mechanically.
The present invention obtains a kind of new technology using property of the glycolipid insoluble in isopropanol, products obtained therefrom viscosity 1000 ~
Between 1500, the product viscosity is moderate, easy to operate during pelleting, and the active ingredient in product and existing process phase
When.
Embodiment
Embodiment one
A, concentrated phosphatide 100kg, isopropanol 250kg is taken to put into container, temperature is maintained at 60 DEG C, stirs 1h；
B, after stirring terminates, vessel temp is maintained at 55 DEG C, stands 2h；
C, supernatant is extracted, filters off the removal of impurity, the isopropanol in heating recovery supernatant, obtains low viscosity phospholipid prod
90kg.In this step, reaction temperature is maintained at 85 DEG C.
Embodiment two
A, concentrated phosphatide 100kg, isopropanol 250kg is taken to put into container, temperature is maintained at 62 DEG C, stirs 1h；
B, after stirring terminates, vessel temp is maintained at 60 DEG C, stands 2h；
C, supernatant is extracted, filters off the removal of impurity, the isopropanol in heating recovery supernatant, obtains low viscosity phospholipid prod
91.5kg.In this step, reaction temperature is maintained at 87 DEG C.
Embodiment three
A, concentrated phosphatide 100kg, isopropanol 250kg is taken to put into container, temperature is maintained at 60 DEG C, stirs 1h；
B, after stirring terminates, vessel temp is maintained at 60 DEG C, stands 2h；
C, supernatant is extracted, is extracted always until the liquid of extraction is muddy shape, stopping filters.The removal of impurity is filtered off, is heated back
The isopropanol in supernatant is received, obtains low viscosity phospholipid prod 89.4kg.In this step, reaction temperature is maintained at 86 DEG C.
To verify the technology of the present invention effect, the present invention is verified using two comparative examples.Comparative example one is using n-hexane to be molten
Agent produces phosphatide, and comparative example two produces phospholipid prod by solvent of ethanol, and its technical process uses prior art.
After testing, above example, comparative example products obtained therefrom reach following index：
Can be found by comparing, products obtained therefrom of the present invention, its viscosity has obvious reduction compared with prior art, its active ingredient with it is existing
Technology is substantially suitable.
Claims (3)
1. a kind of method that low viscosity phospholipid prod is produced with solvent method, comprises the following steps：
A, in mass, according to 1:2.5 ratio takes concentrated phosphatide, isopropanol input container, and temperature is maintained at 60 ± 2 DEG C, stirred
Mix 1h；
B, after stirring terminates, vessel temp is maintained at 55 ~ 60 DEG C, stands 2h；
C, supernatant is extracted, filters off the removal of impurity, the isopropanol in heating recovery supernatant, temperature is maintained at 85 ~ 87 DEG C, obtained
Low viscosity phospholipid prod.
2. the method for low viscosity phospholipid prod is produced with solvent method as claimed in claim 1, it is characterised in that：Described step
In A, 60 DEG C of reaction temperature；In described step B, 55 DEG C of reaction temperature.
3. the method for low viscosity phospholipid prod is produced with solvent method as claimed in claim 1, it is characterised in that：Described step
In C, reaction temperature is maintained at 85 ~ 87 DEG C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710861857.6A CN107522735A (en) | 2017-09-21 | 2017-09-21 | In the method for solvent method production low viscosity phospholipid prod |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710861857.6A CN107522735A (en) | 2017-09-21 | 2017-09-21 | In the method for solvent method production low viscosity phospholipid prod |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107522735A true CN107522735A (en) | 2017-12-29 |
Family
ID=60737097
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710861857.6A Pending CN107522735A (en) | 2017-09-21 | 2017-09-21 | In the method for solvent method production low viscosity phospholipid prod |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107522735A (en) |
Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6061520A (en) * | 1983-09-14 | 1985-04-09 | Q P Corp | Egg yolk phospholipid pharmaceutical |
| EP1013265A2 (en) * | 1998-12-22 | 2000-06-28 | DIANORM G. Maierhofer GmbH | Skin care dispersion composition |
| KR20030081226A (en) * | 2003-09-04 | 2003-10-17 | 경규철 | The method of extract polysaccaride and phospholipid from soybean and the manufactory method of gel phase food that don't come to a hangover. |
| EP1492490A2 (en) * | 2002-03-28 | 2005-01-05 | Beiersdorf AG | Cosmetic or pharmaceutical low-viscosity (atomizable) o/w emulsions containing phospholipids |
| CN103179951A (en) * | 2010-08-20 | 2013-06-26 | 雷迪博士实验室有限公司 | Phospholipid depot |
| US20130202683A1 (en) * | 2007-03-22 | 2013-08-08 | Berg Pharma Llc | Topical formulations having enhanced bioavailability |
| CN103254226A (en) * | 2013-05-08 | 2013-08-21 | 浙江大学 | Method for separating and purifying lecithin through fixed-bed adsorption method |
| CN104370954A (en) * | 2014-09-26 | 2015-02-25 | 福建农林大学 | Method for separating and purifying lecithin in fish roe through silica gel column chromatography |
| WO2015121378A1 (en) * | 2014-02-12 | 2015-08-20 | Aker Biomarine Antarctic As | Liquid phospholipid-containing compositions for the preparation of pharmaceuticals |
| WO2016128830A1 (en) * | 2015-02-11 | 2016-08-18 | Aker Biomarine Antarctic As | Lipid extraction processes |
| CN107632095A (en) * | 2017-09-19 | 2018-01-26 | 中山大学 | A kind of detection method of crop glycolipid and phosphatide |
-
2017
- 2017-09-21 CN CN201710861857.6A patent/CN107522735A/en active Pending
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6061520A (en) * | 1983-09-14 | 1985-04-09 | Q P Corp | Egg yolk phospholipid pharmaceutical |
| EP1013265A2 (en) * | 1998-12-22 | 2000-06-28 | DIANORM G. Maierhofer GmbH | Skin care dispersion composition |
| EP1492490A2 (en) * | 2002-03-28 | 2005-01-05 | Beiersdorf AG | Cosmetic or pharmaceutical low-viscosity (atomizable) o/w emulsions containing phospholipids |
| KR20030081226A (en) * | 2003-09-04 | 2003-10-17 | 경규철 | The method of extract polysaccaride and phospholipid from soybean and the manufactory method of gel phase food that don't come to a hangover. |
| US20130202683A1 (en) * | 2007-03-22 | 2013-08-08 | Berg Pharma Llc | Topical formulations having enhanced bioavailability |
| CN103179951A (en) * | 2010-08-20 | 2013-06-26 | 雷迪博士实验室有限公司 | Phospholipid depot |
| CN103254226A (en) * | 2013-05-08 | 2013-08-21 | 浙江大学 | Method for separating and purifying lecithin through fixed-bed adsorption method |
| WO2015121378A1 (en) * | 2014-02-12 | 2015-08-20 | Aker Biomarine Antarctic As | Liquid phospholipid-containing compositions for the preparation of pharmaceuticals |
| CN104370954A (en) * | 2014-09-26 | 2015-02-25 | 福建农林大学 | Method for separating and purifying lecithin in fish roe through silica gel column chromatography |
| WO2016128830A1 (en) * | 2015-02-11 | 2016-08-18 | Aker Biomarine Antarctic As | Lipid extraction processes |
| CN107632095A (en) * | 2017-09-19 | 2018-01-26 | 中山大学 | A kind of detection method of crop glycolipid and phosphatide |
Non-Patent Citations (4)
| Title |
|---|
| 安红等: ""高PC含量的大豆磷脂的制备研究"", 《精细化工》 * |
| 宋伟等: ""大豆磷脂脱糖实验"", 《中国油脂》 * |
| 李桂华等: ""大豆磷脂中糖脂含量的测定"", 《河南工业大学学报(自然科学版)》 * |
| 蒿丽英等: ""大豆浓缩磷脂中蛋白质及糖类脱除方法的研究"", 《微量元素与健康研究》 * |
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| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20171229 |