CN107468553A - A kind of anti-caries toothpaste - Google Patents
A kind of anti-caries toothpaste Download PDFInfo
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- CN107468553A CN107468553A CN201710635737.4A CN201710635737A CN107468553A CN 107468553 A CN107468553 A CN 107468553A CN 201710635737 A CN201710635737 A CN 201710635737A CN 107468553 A CN107468553 A CN 107468553A
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- cordyceps militaris
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The invention discloses a kind of anti-caries toothpaste, includes Cordyceps militaris elite, sodium monofluorophosphate, calcium glycerophosphate, the alcohol of O cymenes 5, potassium nitrate and natural sugar alcohol.In anti-caries toothpaste of the present invention, Cordyceps militaris elite is compounded jointly with a variety of materials with anti-caries effect and cooperateed with, have the function that significant anti-inflammatory is antibacterial and anti-caries, routine use anti-caries toothpaste of the present invention, comprehensive preventing decayed tooth, the effect of firm tooth can be reached, it contains the antiallergic factor, therefore is applicable sensitivity of tooth patient simultaneously and uses.
Description
Technical field
The present invention relates to a kind of toothpaste, and in particular to a kind of anti-caries toothpaste.
Background technology
Dental caries, it is always common and primary oral problem, for the crowd of all age levels, it is necessary to carry out dental caries and prevent
Shield, otherwise carious tooth can influence the problem of conventional food is chewed, while the tissue such as root of the tooth easily produces inflammation and swelling, pulpitis,
The mouth diseases such as periodontitis just occur in succession.Carious tooth, is disease caused by a kind of tetrad factor, including bacterium, oral environment, place
Main, four big relation factor of time.Wherein bacterium is the pathogenetic necessary condition of dental caries.Cariogenic bacteria has two types, and one kind is production acid
The acid-producing bacteria such as Pseudomonas, predominantly streptococcus mutans (S.mutans), lactobacillus, can make carbohydrate breakdown production acid, cause into
Row tissue is lost, and tooth demineralization, ultimately forms cavity.Another is gram-positive cocci, can destruction of organic material, for a long time
Effect can cause tooth to form cavity.Therefore, the bacterium that killing attaches to facing is the key of preventing decayed tooth.
The content of the invention
A kind of anti-caries toothpaste is provided it is an object of the invention to overcome the shortcomings of the prior art part.
To achieve the above object, the technical scheme taken of the present invention is：A kind of anti-caries toothpaste, comprising Cordyceps militaris elite,
Sodium monofluorophosphate, calcium glycerophosphate, O- cymene -5- alcohol, potassium nitrate and natural sugar alcohol；The Cordyceps militaris elite carries for Cordyceps militaris
Take the mixture of thing and fruiting bodies of cordyceps militaris.
Cordyceps militaris, be the edible mushroom of medicine-food two-purpose, Cordyceps militaris extract of the present invention, can by commercially available,
It can be the refined extract of fruiting bodies of cordyceps militaris gained after water extract-alcohol precipitation.Fruiting bodies of cordyceps militaris is to pass through Cordyceps militaris spawn
It is inoculated on solid medium, after the regular hour cultivates, the stroma of crocus is differentiated to form from hyphostoma development
(fructification), and this new fresh sporophore is gathered into laggard sector-style again and dry grinded obtained by the processing of powder；The two mixture is the present invention
Described Cordyceps militaris elite, wherein the active component contained --- cordycepin, can effectively kill the cariogenic bacteria for attaching to facing,
The effect of so as to reach sterilization preventing decayed tooth.Because cordycepin is the main antipathogenic composition in Cordyceps militaris extract, so Cordyceps militaris is smart
Magnificent addition directly affects content of the cordycepin in formulation of tooth-paste.
And the fruiting bodies of cordyceps militaris in the present invention, it is to be made up of materials such as moisture, ash content, protein, fat, wherein containing
Have a variety of volatile compounds, it is in the majority with aromatic aldehydes material, there is certain antibacterial and anti-inflammatory effect, but aromatic volatile into
Divide can not retain more than one hour under 50 DEG C of extraction temperature.Therefore, can not definitely be purified in above-mentioned refined heating
During remain, therefore by the addition of fruiting bodies of cordyceps militaris, the volatile ingredient of fruiting bodies of cordyceps militaris itself can be allowed complete
Whole enters toothpaste system.
Cordycepin, is first nucleosides separated from fungi antibiotics, molecular structure 3 ,-desoxyadenossine,
There is broad-spectrum antiseptic, research is found, it can suppress the growth of the pathogens such as streptococcus, staphylococcus, and cordycepin
Also there is stronger antiviral activity, thus play in formulation of tooth-paste natural antibacterial, anti-inflammatory, it is antiviral the effect of.Due to worm
Careless element is the main antipathogenic composition in Cordyceps militaris extract, and Cordyceps militaris elite addition directly affects cordycepin in formulation of tooth-paste
In content.
The present invention uses fruiting bodies of cordyceps militaris collocation Cordyceps militaris extract, can make in system containing cordycepin, cordyceps sinensis
Outside the multiple efficacies compositions such as acid, polysaccharide, SOD enzymes, the also volatile ingredient containing fruiting bodies of cordyceps militaris itself, so as to allow preventing decayed tooth
The effect of protecting tooth is played to optimal.
Using toothpaste with fluoride, because its fluorine ion can exchange with the hydroxyl ion in the hydroxyapatite of enamel, turn into more
Add acidproof fluor-apatite, so as to improve the overall capacity antacid of enamel.
Calcium glycerophosphate, it is used for the calcification for promoting bone and tooth in medicine, helps tooth and replenish the calcium, firm tooth.Pin
To oral formulation, calcium glycerophosphate also has the function that antiseptic caries-preventing, can improve the content of calcium and phosphorus in enamel, suppresses tooth
Enamel demineralization, improve its remineralization.
O- cymene -5- alcohol, is a kind of broad-spectrum antibacterial agent, has potent bactericidal action, to staphylococcus aureus, tooth
The oral cavity pathogens such as gum Detection of Porphyromonas all have good antibacterial effect, can penetrate into bacterial plaque inner sterilization, be applied to
The inflammatory patients such as gingivitis, periodontitis, optional commercially available prod, such as Nanjing Si Baike biochemistry Industrial Co., Ltd.
Isopropyl Methylphenol etc..
Potassium nitrate, desensitization activity in the monograph of the desensitizing dental product of food and medicine Surveillance Authority of the U.S. (FDA) into
Point, the release of potassium ion, the nerve endings of dentinal tubule can be prevented to be activated, can be with enough potassium concentrations
Avoid pressing Intradental nerve to be upset, the permeability of dentine is reduced, so as to slow down the situation of dentine hypersensitivity.
Cordyceps militaris elite and a variety of materials with anti-caries effect are used cooperatively down by anti-caries toothpaste of the present invention,
With significant effects of antiinflammation and bacteriostasis, there is stronger anti-caries effect, anti-inflammatory is antibacterial and anti-caries effect significantly increases, in pupa worm
Careless elite is with the synergy of multiple preventing decayed tooth composition, comprehensive preventing decayed tooth, strengthening tooth, while make suitable for sensitivity of tooth patient
With.
Preferably, in the preparing raw material of the anti-caries toothpaste, the weight percentage of the Cordyceps militaris elite is 0.1
~5%, the weight percentage of the calcium glycerophosphate is 0.1~0.8%, and the weight percent of the O- cymenes -5- alcohol contains
Measure as 0.01~0.1%, the weight percentage of the potassium nitrate is 3~10%, the weight percentage of the natural sugar alcohol
For 0.5~10%.
Study and draw repeatedly through inventor, when the content of Cordyceps militaris elite is less than 0.1%, the bacteriostasis of toothpaste does not show
Write, with the increase of the content of Cordyceps militaris elite, bacteriostasis strengthens, but when the content of Cordyceps militaris elite is more than 5%, with
The addition increase of Cordyceps militaris elite, fungistatic effect increase is not notable, when the content of Cordyceps militaris elite is 0.1~5%, tool
There is preferable bactericidal action；When each component cooperates under the ratio, anti-inflammatory is antibacterial and anti-caries effect significantly increases, in pupa
For Lungfit with the synergy of multiple preventing decayed tooth composition, can effectively prevent carious tooth from continuing lesion, anti-inflammatory is antibacterial and strengthens tooth,
Used simultaneously suitable for sensitivity of tooth patient.
It is highly preferred that in the preparing raw material of the anti-caries toothpaste, the weight percentage of the Cordyceps militaris elite is
0.5~3%, the weight percentage of the calcium glycerophosphate is 0.1~0.5%, the weight percent of the O- cymenes -5- alcohol
Content is 0.05~0.08%, and the weight percentage of the potassium nitrate is 3~5%, and the weight percent of the natural sugar alcohol contains
Measure as 0.5~5%.
Study and draw repeatedly through inventor, when each group is divided into above-mentioned content, the anti-inflammation and sterilization of toothpaste of the present invention is made
With with anti-caries best results.
Preferably, the concentration for the fluoride ion that the fluoride provides in the anti-caries toothpaste is 850~1500mg/
kg。
The concentration of fluoride ion in anti-caries toothpaste of the present invention within the above range when, preferable anti-caries can be played
Tooth effect.
Preferably, the fluoride is at least one of sodium fluoride, sodium monofluorophosphate and stannous fluoride；The natural sugar
Alcohol is erythrite and/or xylitol.
Fluoride of the present invention can select at least one of sodium fluoride, sodium monofluorophosphate and stannous fluoride, these
It is the preferable fluoride of safety.Such as when sodium fluoride is individually in anti-caries toothpaste of the present invention in use, the fluorination
Weight percentage of the sodium in the anti-caries toothpaste is 0.18~0.33%, when sodium monofluorophosphate is individually of the present invention
In anti-caries toothpaste in use, weight percentage of the sodium monofluorophosphate in the anti-caries toothpaste be 0.654~
1.153%, when stannous fluoride is individually in anti-caries toothpaste of the present invention in use, the stannous fluoride is in the anti-caries
Weight percentage in toothpaste is 0.35~0.62%, can also use a variety of fluoride compounding uses according to demand.
Xylitol belongs to natural sugar alcohol with antierythrite, functional sweetener is can also serve as, suitable for diabetes
People uses.Two kinds of natural sugar alcohols also have the function that only dental caries, preventing decayed tooth, contrast pure D-sorbite, are containing Streptococcus mutans (dental caries
Pathogenic bacteria) environment in, add erythrite and/or xylitol, the decline of pH value can be preferably prevented, so as to prevent acyclic acidic
Tooth is destroyed in border, avoids the formation of dental caries.
Preferably, the weight ratio of the Cordyceps militaris extract and fruiting bodies of cordyceps militaris is：Cordyceps militaris extract：Cordyceps militaris
Entity=80~99.9：0.01~20.
When Cordyceps militaris extract and fruiting bodies of cordyceps militaris use above-mentioned weight ratio, both can give full play to respective effect,
System is set to contain cordycepin, cordycepic acid, polysaccharide, SOD enzymes and a variety of volatile compounds, so as to reach antibacterial anti-caries
Effect.
It is highly preferred that the weight ratio of the Cordyceps militaris extract and fruiting bodies of cordyceps militaris is：Cordyceps militaris extract：Cordyceps militaris
Fructification=85~92：8~15.
When Cordyceps militaris extract and fruiting bodies of cordyceps militaris use above-mentioned weight ratio, the bactericidal effect that toothpaste reaches is optimal.
Preferably, the preparing raw material of the anti-caries toothpaste also includes NMF, rubbing agent, thickener and foaming agent；Institute
In the preparing raw material for stating anti-caries toothpaste, the weight percentage of the NMF is 35~50%, the weight of the rubbing agent
Percentage composition is 14~30%, and the weight percentage of the thickener is 0.5~3%, and the weight percent of the foaming agent contains
Measure as 1.8~3%.
Preferably, the foaming agent is at least one of amino acid surfactant and amphoteric surfactant and 12
The mixture of sodium alkyl sulfate.
It is highly preferred that the foaming agent is sodium lauroyl sarcosine, sodium lauroylmethyl taurate and cocamidopropyl propyl amide
At least one of glycine betaine and the mixture of lauryl sodium sulfate.
When foaming agent of the present invention only uses lauryl sodium sulfate, foam is few and thin, and mouthfeel of brushing teeth is slightly poor, ammonia of arranging in pairs or groups
When at least one of base acid surfaces activating agent, amphoteric surfactant, lather quickness can be accelerated, foam is fine and smooth abundant, solution
Certainly dry and astringent still sensory issues.The foaming agent is selected from commercially available prod, for example, Shanghai Austria can be selected in sodium lauroyl sarcosine
The OLI-4901 of Shanghai profit difficult to understand, Cocoamidopropyl betaine can be selected in the OLI-4208 of profit, lauroyl N-methyltaurine sodium
Galaxy Surfactants CAPB DC, the Lenotain C30 that Shanghai profit is contained can be selected, wherein CAPB DC are specially for suitable.
Preferably, the rubbing agent be precipitated silica, superfine silicon dioxide, calcium monohydrogen phosphate and calcium carbonate at least
It is a kind of.
It is highly preferred that the rubbing agent be at least one of precipitated silica, calcium monohydrogen phosphate and calcium carbonate with it is ultra-fine
The mixture of silica, wherein, in the preparing raw material of the anti-caries toothpaste, the weight percentage of superfine silicon dioxide is
2~6%.
Weight percentage of the superfine silicon dioxide in the preparing raw material of the toothpaste is 2~6%.When ultra-fine two
When silica dosage is less than 2%, lotion surface is more rough, and mouthfeel of brushing teeth can be poor, when superfine silicon dioxide dosage is more than 6%
When, be easily hardened under lotion high temperature water outlet, influences stability.The liquid absorption of superfine silicon dioxide is 30~44ml/20g, preferably
30~38ml/20g superfine silicon dioxide, commercially available prod, such as comprehensive silica of snow company etc. can be used.It is heavy
The liquid absorption of shallow lake type silica is 15~25ml/20g, preferably 18~22ml/20g Precipitated silicon dioxide, can be used
Commercially available prod, such as Zeodent115 of HUBER companies etc..The liquid absorption of calcium bicarbonate is 5.0~6.5ml/20g, apparent close
Spend and tend to maximum, while apparent density trend minimum value for 0.80~1.00g/mL, preferably liquid absorption, commercially available production can be used
Product, such as toothpaste grade calcium hydrophosphate of De Bang companies etc..The liquid absorption of calcium carbonate is 3.8~5.0ml/20g, preferably 3.8~
4.2ml/20g calcium carbonate, commercially available prod, such as calcite in powder of Man Tingfang companies etc. can be used.
Preferably, the thickener is at least one of sodium carboxymethylcellulose, carbomer and xanthans；The moisturizing
Agent is at least one of D-sorbite, glycerine, polyethylene glycol and propane diols.
Commercially available prod can be selected in sodium carboxymethylcellulose, such as the TH10 (toothpaste level) of ASHLAND companies, its substitution value are
0.75~1.02, preferably 0.95~1.02,2% solution viscosity are 600~3000mPas, preferably 1200~
2500mPas cellulose.Carbomer can be selected commercially available prod, such as Lubrizol companies
POLYMER (toothpaste level), pH value is adjusted in 7 or so (in 6.5-7.5 interval ranges), use with 25%NaOH solution
Brookfield RV6 rotors survey its viscosity, 0.6% neutralization solution viscosity under 20rpm：15000~40000mPas,
It is preferred that in 20000~30000mPas.Xanthans, also known as xanthan gum, optional commercially available prod, such as CPKelco companiesXanthan Gum (oral cavity level), its 1% xanthans are turned with Brookfield RV6 in 1%KCl solution
Son surveys its viscosity under 20rpm, and viscosity is 1200~1600mPas.
The anti-caries toothpaste of the present invention, in addition to said components clearly require, in the scope of lossless effect of the invention
It is interior, other adjunct ingredients can be added or used to, auxiliary material can be sweetener, pH adjusting agent, spices and colouring agent etc., this area
Technical staff can select conventional content according to conventional criteria.
Preferably, the anti-caries toothpaste also includes the composition of following mass percent：Sweetener 0.1~2%, pH regulations
Agent 0.1~3% and spices 0.1~2%.
Preferably, the sweetener is at least one of saccharin sodium, Sucralose and STEVIA REBAUDIANA；The spices is peppermint
At least one of brain, peppermint oil, spearmint oil, wintergreen, American mint, orange oil, lemon oil, fennel oil, eucalyptus oil；Institute
PH adjusting agent is stated as at least one in sodium hydroxide, ATSP, sodium tripolyphosphate, alkaline phosphate and sodium dihydrogen phosphate
Kind.
The preparation method of above-mentioned anti-caries toothpaste, comprises the following steps：
(1), potassium nitrate and auxiliary material are pre-dissolved；
(2), rubbing agent, thickener are premixed；
(3), the material in NMF and step (1) is added in cream tank processed；
(4) vacuum system of cream tank processed, is opened, is vacuumized, mixture, Cordyceps militaris elite, O- umbrellas obtained by step (2) are spent
Hydrocarbon -5- alcohol, potassium nitrate, sodium phytate, zinc citrate and polyvinylpyrrolidone add, keep vacuum -0.05Mpa~-
Homogeneous is stirred between 0.085Mpa；
(5) foaming agent, is added in cream tank processed, keeps vacuum to continue stirring between -0.05Mpa~-0.085Mpa equal
Matter；
(6), will cream tank processed to deaerate to vacuum be -0.092Mpa~-0.098Mpa, go out cream, produce the preventing decayed tooth teeth
Cream.
The beneficial effects of the present invention are：The invention provides a kind of anti-caries toothpaste, anti-caries toothpaste of the present invention
Cordyceps militaris elite and a variety of materials with anti-caries effect are used cooperatively down, there is significant effects of antiinflammation and bacteriostasis, have compared with
Strong anti-caries effect, anti-inflammatory is antibacterial and anti-caries effect significantly increases, in cooperateing with for Cordyceps militaris elite and multiple preventing decayed tooth composition
Under effect, comprehensive preventing decayed tooth, strengthen tooth, while use suitable for sensitivity of tooth patient.
Brief description of the drawings
Fig. 1 is antibacterial test comparison figure of the embodiment 5 with 1~6 toothpaste of comparative example to staphylococcus aureus；
Fig. 2 is antibacterial test comparison figure of the embodiment 5 with 1~6 toothpaste of comparative example to streptococcus mutans；
Fig. 3 is antibacterial test comparison figure of the embodiment 5 with 1~6 toothpaste of comparative example to porphyromonas monococcus.
Embodiment
To better illustrate the object, technical solutions and advantages of the present invention, below in conjunction with specific embodiment to the present invention
It is described further.
Embodiment 1
A kind of embodiment of anti-caries toothpaste of the present invention, include the preparing raw material of following weight percentage：Pupa worm
Careless elite 0.1%, sodium monofluorophosphate 0.654%, calcium glycerophosphate 0.1%, O- cymene -5- alcohol 0.01%, potassium nitrate 3%,
Xylitol 0.5%, NMF 50%, rubbing agent 14%, thickener 0.5%, foaming agent 1.8%, sweetener 0.1%, pH regulations
The deionized water of agent 0.1%, spices 0.1% and surplus；
Wherein, the Cordyceps militaris elite is the mixture of Cordyceps militaris extract and fruiting bodies of cordyceps militaris, and the Cordyceps militaris carries
The weight of the thing and fruiting bodies of cordyceps militaris ratio is taken to be：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=99.9：0.01；The NMF
For D-sorbite；The thickener is sodium carboxymethylcellulose；The foaming agent is sodium lauroyl sarcosine and dodecyl sulphur
The mixture of sour sodium；The mixture of the rubbing agent precipitated silica and superfine silicon dioxide, superfine silicon dioxide is described
Weight percentage in the preparing raw material of anti-caries toothpaste is 2%；The sweetener is saccharin sodium；The spices is peppermint
Brain；The pH adjusting agent is alkaline phosphate and sodium dihydrogen phosphate.
Embodiment 2
A kind of embodiment of anti-caries toothpaste of the present invention, include the preparing raw material of following weight percentage：Pupa worm
Careless elite 5%, stannous fluoride 0.62%, calcium glycerophosphate 0.8%, O- cymene -5- alcohol 0.1%, potassium nitrate 10%, xylitol
10%th, NMF 35%, rubbing agent 20%, thickener 3%, foaming agent 3%, sweetener 2%, pH adjusting agent 3%, spices 2%
With the deionized water of surplus；
Wherein, the Cordyceps militaris elite is the mixture of Cordyceps militaris extract and fruiting bodies of cordyceps militaris, and the Cordyceps militaris carries
The weight of the thing and fruiting bodies of cordyceps militaris ratio is taken to be：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=80：20；The NMF is mountain
The mixture of pears sugar alcohol and glycerine；The thickener is the mixture of sodium carboxymethylcellulose and carbomer；The foaming agent is
The mixture of sodium lauroylmethyl taurate and lauryl sodium sulfate；The rubbing agent is calcium monohydrogen phosphate and superfine silicon dioxide
Mixture, weight percentage of the superfine silicon dioxide in the preparing raw material of the anti-caries toothpaste be 6%；The sweet taste
Agent is Sucralose；The spices is spearmint oil；The pH adjusting agent is sodium hydroxide.
Embodiment 3
A kind of embodiment of anti-caries toothpaste of the present invention, include the preparing raw material of following weight percentage：Pupa worm
Careless elite 0.5%, sodium fluoride 0.33%, calcium glycerophosphate 0.1%, O- cymene -5- alcohol 0.05%, potassium nitrate 3%, erythrite
0.5%th, NMF 40%, rubbing agent 30%, thickener 0.5%, foaming agent 1.8%, sweetener 0.1%, pH adjusting agent
0.1%th, spices 0.1%, the deionized water of surplus；
Wherein, the Cordyceps militaris elite is the mixture of Cordyceps militaris extract and fruiting bodies of cordyceps militaris, and the Cordyceps militaris carries
The weight of the thing and fruiting bodies of cordyceps militaris ratio is taken to be：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=92：8；The NMF is sorb
The mixture of sugar alcohol and propane diols；The thickener is the mixture in sodium carboxymethylcellulose and xanthans；The foaming agent
For Cocoamidopropyl betaine and the mixture of lauryl sodium sulfate；The rubbing agent is calcium carbonate and superfine silicon dioxide
Mixture, weight percentage of the superfine silicon dioxide in the preparing raw material of the anti-caries toothpaste be 4%；The sweet taste
Agent is STEVIA REBAUDIANA；The spices is lemon oil；The pH adjusting agent is ATSP.
Embodiment 4
A kind of embodiment of anti-caries toothpaste of the present invention, include the preparing raw material of following weight percentage：Pupa worm
Careless elite 3%, sodium fluoride 0.18%, calcium glycerophosphate 0.5%, O- cymene -5- alcohol 0.08%, potassium nitrate 5%, erythrite
5%th, NMF 45%, rubbing agent 20%, thickener 2%, foaming agent 2%, sweetener 1%, pH adjusting agent 2%, the and of spices 1%
The deionized water of surplus；
Wherein, the Cordyceps militaris elite is the mixture of Cordyceps militaris extract and fruiting bodies of cordyceps militaris, and the Cordyceps militaris carries
The weight of the thing and fruiting bodies of cordyceps militaris ratio is taken to be：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=85：15；NMF is sorbose
The mixture of alcohol and glycerine；The thickener is carbomer；The foaming agent is sodium lauroyl sarcosine, lauroyl methyl ox sulphur
The mixture of sour sodium and lauryl sodium sulfate；The rubbing agent is the mixture of precipitated silica and superfine silicon dioxide,
Weight percentage of the superfine silicon dioxide in the preparing raw material of the anti-caries toothpaste is 6%；The sweetener is saccharin
Sodium；The spices is orange oil；The pH adjusting agent is ATSP.
Embodiment 5
A kind of embodiment of anti-caries toothpaste of the present invention, include the preparing raw material of following weight percentage：Pupa worm
Careless elite 2.5%, sodium fluoride 0.3%, calcium glycerophosphate 0.3%, O- cymene -5- alcohol 0.05%, potassium nitrate 4%, erythrite
3%th, NMF 30%, rubbing agent 22%, thickener 2%, foaming agent 2%, sweetener 1%, pH adjusting agent 2%, the and of spices 1%
The deionized water of surplus；
Wherein, the Cordyceps militaris elite is the mixture of Cordyceps militaris extract and fruiting bodies of cordyceps militaris, and the Cordyceps militaris carries
The weight of the thing and fruiting bodies of cordyceps militaris ratio is taken to be：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=90：10；NMF is sorbose
The mixture of alcohol and glycerine；The thickener is carbomer；The foaming agent is sodium lauroyl sarcosine, lauroyl methyl ox sulphur
The mixture of sour sodium and lauryl sodium sulfate；The rubbing agent is the mixture of precipitated silica and superfine silicon dioxide,
Weight percentage of the superfine silicon dioxide in the preparing raw material of the anti-caries toothpaste is 4%；The sweetener is saccharin
Sodium；The spices is orange oil；The pH adjusting agent is ATSP.
Embodiment 6
A kind of embodiment of anti-caries toothpaste of the present invention, the present embodiment anti-caries toothpaste and the preventing decayed tooth teeth of embodiment 5
The difference of the content that the difference is that only Cordyceps militaris elite of cream, the Cordyceps militaris elite of anti-caries toothpaste described in the present embodiment exist
Weight percentage in the preparing raw material of toothpaste is 5%.
Embodiment 7
A kind of embodiment of anti-caries toothpaste of the present invention, the present embodiment anti-caries toothpaste and the preventing decayed tooth teeth of embodiment 5
The difference of the content that the difference is that only Cordyceps militaris elite of cream, the Cordyceps militaris elite of anti-caries toothpaste described in the present embodiment exist
Weight percentage in the preparing raw material of toothpaste is 4%.
Embodiment 8
A kind of embodiment of anti-caries toothpaste of the present invention, the present embodiment anti-caries toothpaste and the preventing decayed tooth teeth of embodiment 5
The difference of the content that the difference is that only Cordyceps militaris elite of cream, the Cordyceps militaris elite of anti-caries toothpaste described in the present embodiment exist
Weight percentage in the preparing raw material of toothpaste is 2%.
Embodiment 9
A kind of embodiment of anti-caries toothpaste of the present invention, the present embodiment anti-caries toothpaste and the preventing decayed tooth teeth of embodiment 5
The difference of the content that the difference is that only Cordyceps militaris elite of cream, the Cordyceps militaris elite of anti-caries toothpaste described in the present embodiment exist
Weight percentage in the preparing raw material of toothpaste is 1%.
Embodiment 10
A kind of embodiment of anti-caries toothpaste of the present invention, the present embodiment anti-caries toothpaste and the preventing decayed tooth teeth of embodiment 5
The difference of the content that the difference is that only Cordyceps militaris elite of cream, the Cordyceps militaris elite of anti-caries toothpaste described in the present embodiment exist
Weight percentage in the preparing raw material of toothpaste is 0.1%.
Embodiment 11
A kind of embodiment of anti-caries toothpaste of the present invention, the preparing raw material of toothpaste described in the present embodiment and embodiment 5
The weight that the difference is that only Cordyceps militaris extract and fruiting bodies of cordyceps militaris than difference, Cordyceps militaris described in the present embodiment carries
The weight of the thing and fruiting bodies of cordyceps militaris ratio is taken to be：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=99.9：0.01.
Embodiment 12
A kind of embodiment of anti-caries toothpaste of the present invention, the preparing raw material of toothpaste described in the present embodiment and embodiment 5
The weight that the difference is that only Cordyceps militaris extract and fruiting bodies of cordyceps militaris than difference, Cordyceps militaris described in the present embodiment carries
The weight of the thing and fruiting bodies of cordyceps militaris ratio is taken to be：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=95：5.
Embodiment 13
A kind of embodiment of anti-caries toothpaste of the present invention, the preparing raw material of toothpaste described in the present embodiment and embodiment 5
The weight that the difference is that only Cordyceps militaris extract and fruiting bodies of cordyceps militaris than difference, Cordyceps militaris described in the present embodiment carries
The weight of the thing and fruiting bodies of cordyceps militaris ratio is taken to be：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=92：8.
Embodiment 14
A kind of embodiment of anti-caries toothpaste of the present invention, the preparing raw material of toothpaste described in the present embodiment and embodiment 5
The weight that the difference is that only Cordyceps militaris extract and fruiting bodies of cordyceps militaris than difference, Cordyceps militaris described in the present embodiment carries
The weight of the thing and fruiting bodies of cordyceps militaris ratio is taken to be：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=85：15.
Embodiment 15
A kind of embodiment of anti-caries toothpaste of the present invention, the preparing raw material of toothpaste described in the present embodiment and embodiment 5
The weight that the difference is that only Cordyceps militaris extract and fruiting bodies of cordyceps militaris than difference, Cordyceps militaris described in the present embodiment carries
The weight of the thing and fruiting bodies of cordyceps militaris ratio is taken to be：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=80：20.
Comparative example 1
A kind of comparative example of anti-caries toothpaste of the present invention, the preparing raw material of toothpaste described in this comparative example and embodiment 5
Difference be, in the preparing raw material of toothpaste described in this comparative example without Cordyceps militaris elite, sodium monofluorophosphate, phosphoglycerol
Calcium, O- cymene -5- alcohol and erythrite, i.e. toothpaste described in this comparative example include the preparing raw material of following weight percentage：Nitre
Sour potassium 4%, NMF 50%, rubbing agent 22%, thickener 2%, foaming agent 2%, sweetener 1%, pH adjusting agent 2%, spices
1% and the deionized water of surplus；
Wherein, NMF is the mixture of D-sorbite and glycerine；The thickener is carbomer；The foaming agent is the moon
The mixture of osmanthus acylsarcosine sodium, sodium lauroylmethyl taurate and lauryl sodium sulfate；The rubbing agent is precipitation dioxy
The mixture of SiClx and superfine silicon dioxide, weight percent of the superfine silicon dioxide in the preparing raw material of the anti-caries toothpaste
Content is 4%；The sweetener is saccharin sodium；The spices is orange oil；The pH adjusting agent is ATSP.
Comparative example 2
A kind of comparative example of anti-caries toothpaste of the present invention, the preparing raw material of toothpaste described in this comparative example and embodiment 5
Difference be, in the preparing raw material of toothpaste described in this comparative example without sodium monofluorophosphate, calcium glycerophosphate, O- cymenes-
Toothpaste includes the preparing raw material of following weight percentage described in 5- alcohol, potassium nitrate and erythrite, i.e. this comparative example：Cordyceps militaris essence
China 2.5%, potassium nitrate 4%, NMF 50%, rubbing agent 22%, thickener 2%, foaming agent 2%, sweetener 1%, pH regulations
The deionized water of agent 2%, spices 1% and surplus；
Wherein, NMF is the mixture of D-sorbite and glycerine；The thickener is carbomer；The foaming agent is the moon
The mixture of osmanthus acylsarcosine sodium, sodium lauroylmethyl taurate and lauryl sodium sulfate；The rubbing agent is precipitation dioxy
The mixture of SiClx and superfine silicon dioxide, weight percent of the superfine silicon dioxide in the preparing raw material of the anti-caries toothpaste
Content is 4%；The sweetener is saccharin sodium；The spices is orange oil；The pH adjusting agent is ATSP.
Comparative example 3
A kind of comparative example of anti-caries toothpaste of the present invention, the preparing raw material of toothpaste described in this comparative example and embodiment 5
Difference be, in the preparing raw material of toothpaste described in this comparative example without Cordyceps militaris elite, calcium glycerophosphate, O- cymenes-
Toothpaste includes the preparing raw material of following weight percentage described in 5- alcohol and erythrite, i.e. this comparative example：Sodium monofluorophosphate
0.8%th, potassium nitrate 4%, NMF 50%, rubbing agent 22%, thickener 2%, foaming agent 2%, sweetener 1%, pH adjusting agent
2%th, the deionized water of spices 1% and surplus；
Wherein, NMF is the mixture of D-sorbite and glycerine；The thickener is carbomer；The foaming agent is the moon
The mixture of osmanthus acylsarcosine sodium, sodium lauroylmethyl taurate and lauryl sodium sulfate；The rubbing agent is precipitation dioxy
The mixture of SiClx and superfine silicon dioxide, weight percent of the superfine silicon dioxide in the preparing raw material of the anti-caries toothpaste
Content is 4%；The sweetener is saccharin sodium；The spices is orange oil；The pH adjusting agent is ATSP.
Comparative example 4
A kind of comparative example of anti-caries toothpaste of the present invention, the preparing raw material of toothpaste described in this comparative example and embodiment 5
Difference be, in the preparing raw material of toothpaste described in this comparative example without Cordyceps militaris elite, sodium monofluorophosphate, O- cymenes-
Toothpaste includes the preparing raw material of following weight percentage described in 5- alcohol and erythrite, i.e. this comparative example：Calcium glycerophosphate
0.3%th, potassium nitrate 4%, NMF 50%, rubbing agent 22%, thickener 2%, foaming agent 2%, sweetener 1%, pH adjusting agent
2%th, the deionized water of spices 1% and surplus；
Wherein, NMF is the mixture of D-sorbite and glycerine；The thickener is carbomer；The foaming agent is the moon
The mixture of osmanthus acylsarcosine sodium, sodium lauroylmethyl taurate and lauryl sodium sulfate；The rubbing agent is precipitation dioxy
The mixture of SiClx and superfine silicon dioxide, weight percent of the superfine silicon dioxide in the preparing raw material of the anti-caries toothpaste
Content is 4%；The sweetener is saccharin sodium；The spices is orange oil；The pH adjusting agent is ATSP.
Comparative example 5
A kind of comparative example of anti-caries toothpaste of the present invention, the preparing raw material of toothpaste described in this comparative example and embodiment 5
Difference be, in the preparing raw material of toothpaste described in this comparative example without Cordyceps militaris elite, sodium monofluorophosphate, phosphoglycerol
Toothpaste includes the preparing raw material of following weight percentage described in calcium and erythrite, i.e. this comparative example：O- cymene -5- alcohol
0.05%th, potassium nitrate 4%, NMF 50%, rubbing agent 22%, thickener 2%, foaming agent 2%, sweetener 1%, pH adjusting agent
2%th, the deionized water of spices 1% and surplus；
Wherein, NMF is the mixture of D-sorbite and glycerine；The thickener is carbomer；The foaming agent is the moon
The mixture of osmanthus acylsarcosine sodium, sodium lauroylmethyl taurate and lauryl sodium sulfate；The rubbing agent is precipitation dioxy
The mixture of SiClx and superfine silicon dioxide, weight percent of the superfine silicon dioxide in the preparing raw material of the anti-caries toothpaste
Content is 4%；The sweetener is saccharin sodium；The spices is orange oil；The pH adjusting agent is ATSP.
Comparative example 6
A kind of comparative example of anti-caries toothpaste of the present invention, the preparing raw material of toothpaste described in this comparative example and embodiment 5
Difference be, in the preparing raw material of toothpaste described in this comparative example without Cordyceps militaris elite, sodium monofluorophosphate, calcium glycerophosphate
With O- cymene -5- alcohol, i.e. toothpaste described in this comparative example includes the preparing raw material of following weight percentage：It is potassium nitrate 4%, red
Moss alcohol 3%, NMF 50%, rubbing agent 22%, thickener 2%, foaming agent 2%, sweetener 1%, pH adjusting agent 2%, spices
1% and the deionized water of surplus；
Wherein, NMF is the mixture of D-sorbite and glycerine；The thickener is carbomer；The foaming agent is the moon
The mixture of osmanthus acylsarcosine sodium, sodium lauroylmethyl taurate and lauryl sodium sulfate；The rubbing agent is precipitation dioxy
The mixture of SiClx and superfine silicon dioxide, weight percent of the superfine silicon dioxide in the preparing raw material of the anti-caries toothpaste
Content is 4%；The sweetener is saccharin sodium；The spices is orange oil；The pH adjusting agent is ATSP.
Comparative example 7
A kind of comparative example of anti-caries toothpaste of the present invention, the preparing raw material of toothpaste described in this comparative example and embodiment 5
The content that the difference is that only Cordyceps militaris elite difference, the Cordyceps militaris elite of anti-caries toothpaste described in the present embodiment is in tooth
Weight percentage in the preparing raw material of cream is 6%.
Comparative example 8
A kind of comparative example of anti-caries toothpaste of the present invention, the preparing raw material of toothpaste described in this comparative example and embodiment 5
The weight that the difference is that only Cordyceps militaris extract and fruiting bodies of cordyceps militaris than difference, Cordyceps militaris described in this comparative example carries
The weight of the thing and fruiting bodies of cordyceps militaris ratio is taken to be：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=100:0.
Comparative example 9
A kind of comparative example of anti-caries toothpaste of the present invention, the preparing raw material of toothpaste described in this comparative example and embodiment 5
The weight that the difference is that only Cordyceps militaris extract and fruiting bodies of cordyceps militaris than difference, Cordyceps militaris described in this comparative example carries
The weight of the thing and fruiting bodies of cordyceps militaris ratio is taken to be：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=75:25.
Embodiment 16
To the anti-caries toothpaste of embodiment 1~15 and 1~9 toothpaste of comparative example for common several bacteriums in oral cavity
Carry out antibacterial test.
Antibacterial method of testing：According to《Disinfection technology standard》2.1.8. anti-(suppression) equal test method, passes through third party's machine
Structure is tested.
The preparation of bacteria inhibition tablet：In the sterilized petri dishes of cleaning, a diameter of 5mm is made, thickness is no more than the suppression of 4mm disks (block)
Microbial inoculum original cream piece, one group of every 4 (blocks).
The preparation of negative control piece：Take sterile dry filter paper piece, every be added dropwise it is standby after sterile distilled water.
The inoculation of test organisms：Concentration is dipped as 5 × 10 with sterile cotton swab5Cfu/ml~5 × 106Cfu/ml test organisms hangs
Liquid, nutrient agar planar surface uniformly smear 3 times, often smear 1 time, flat board should rotate 60 °, finally by cotton swab around
Plate edge is smeared one week, is covered plate, is put drying at room temperature 5min.
Bacteriostatic agent print is placed with：Experiment is placed with 1 microbiological contamination flat board every time, and each flat board is placed with the examination of 4 same test groups
Test print, 1 negative control piece, totally 5.It is placed with aseptic nipper coupongs in planar surface.Between each print center apart
More than 25mm, the periphery with flat board is at a distance of more than 15mm.After being placed with,
With the light pressure-like piece of aseptic nipper, it is set to be close to planar surface.Plate is covered, puts 37 DEG C of incubators, culture 16h~
18h observes result.With the direct of vernier caliper measurement antibacterial ring size and record, experiment is repeated 3 times.
The bacterial strain of this test has selected common oral cavity pathogen：Staphylococcus aureus, streptococcus mutans and gum
Porphyrin monococcus.
Antibacterial test evaluation standard：Inhibition zone diameter is more than 7mm person, has been judged to bacteriostasis；Inhibition zone diameter be less than or
Equal to 7mm person, no bacteriostasis is judged to.The antibacterial test result of 1~7 toothpaste of embodiment 1~10 and comparative example is shown in Table 1,
Embodiment 5 and the antibacterial test comparison of 1~6 toothpaste of comparative example are shown in accompanying drawing 1~3, embodiment 5,11~15 and comparative example 7,8
The antibacterial test result of the toothpaste is shown in Table 2.
The antibacterial test result of 1~7 toothpaste of the embodiment 1~10 of table 1 and comparative example
As it can be seen from table 1 the fungistatic effect of the anti-caries toothpaste of embodiment 1~10 is better than 1~7 tooth of comparative example
The fungistatic effect of cream, the fungistatic effect of embodiment 5 and comparative example 1~6 is contrasted and can drawn especially from accompanying drawing 1~3, embodiment
5 fungistatic effect is more than Cordyceps militaris elite, sodium monofluorophosphate, calcium glycerophosphate, O- cymene -5- alcohol, potassium nitrate and natural sugar
Alcohol one or more therein, illustrate Cordyceps militaris elite, sodium monofluorophosphate, calcium glycerophosphate, O- cymene -5- alcohol, potassium nitrate
Synergistic can be played a part of by being compounded with natural sugar alcohol in certain proportion.From embodiment 5~10 and comparative example 7
Fungistatic effect comparative example can show that, with the increase of the addition of Cordyceps militaris elite, fungistatic effect increases, but comparative example 7
Compared with Example 6, addition adds 1%, but fungistatic effect increases unobvious.
The embodiment 5,11~15 of table 2 and comparative example 7, the antibacterial test result of 8 toothpaste
From table 2 it can be seen that in the case where Cordyceps militaris elite content is certain, with the increasing of fruiting bodies of cordyceps militaris content
Greatly, the fungistatic effect of made toothpaste is in the trend for first increasing and reducing afterwards, and real in Cordyceps militaris extract and Cordyceps militaris
The weight ratio of body is：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=85~92：Effect reaches optimal when 8~15.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than the present invention is protected
The limitation of scope is protected, although being explained in detail with reference to preferred embodiment to the present invention, one of ordinary skill in the art should
Understand, technical scheme can be modified or equivalent substitution, without departing from the essence of technical solution of the present invention
And scope.
Claims (10)
1. a kind of anti-caries toothpaste, it is characterised in that include Cordyceps militaris elite, fluoride, calcium glycerophosphate, O- cymenes -5-
Alcohol, potassium nitrate and natural sugar alcohol；The Cordyceps militaris elite is the mixture of Cordyceps militaris extract and fruiting bodies of cordyceps militaris.
2. anti-caries toothpaste as claimed in claim 1, it is characterised in that described in the preparing raw material of the anti-caries toothpaste
The weight percentage of Cordyceps militaris elite is 0.1~5%, and the weight percentage of the calcium glycerophosphate is 0.1~0.8%,
The weight percentage of the O- cymenes -5- alcohol is 0.01~0.1%, the weight percentage of the potassium nitrate for 3~
10%, the weight percentage of the natural sugar alcohol is 0.5~10%.
3. anti-caries toothpaste as claimed in claim 1, it is characterised in that described in the preparing raw material of the anti-caries toothpaste
The weight percentage of Cordyceps militaris elite is 0.5~3%, and the weight percentage of the calcium glycerophosphate is 0.1~0.5%,
The weight percentage of the O- cymenes -5- alcohol is 0.05~0.08%, the weight percentage of the potassium nitrate for 3~
5%, the weight percentage of the natural sugar alcohol is 0.5~5%.
4. anti-caries toothpaste as claimed in claim 1, it is characterised in that the fluoride contains what the anti-caries toothpaste provided
The concentration of fluorine ion is 850~1500mg/kg.
5. anti-caries toothpaste as claimed in claim 1, it is characterised in that the fluoride is sodium fluoride, sodium monofluorophosphate and fluorine
Change at least one of stannous；The natural sugar alcohol is erythrite and/or xylitol.
6. anti-caries toothpaste as claimed in claim 1, it is characterised in that the weight of the Cordyceps militaris extract and fruiting bodies of cordyceps militaris
Measuring ratio is：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=80~99.9：0.01~20；Preferably, the Cordyceps militaris extract and
The weight ratio of fruiting bodies of cordyceps militaris is：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=85~92：8~15.
7. anti-caries toothpaste as claimed in claim 1, it is characterised in that the preparing raw material of the anti-caries toothpaste also includes moisturizing
Agent, rubbing agent, thickener and foaming agent；In the preparing raw material of the anti-caries toothpaste, the weight percentage of the NMF
For 35~50%, the weight percentage of the rubbing agent is 14~30%, the weight percentage of the thickener for 0.5~
3%, the weight percentage of the foaming agent is 1.8~3%.
8. anti-caries toothpaste as claimed in claim 7, it is characterised in that the foaming agent is amino acid surfactant and both sexes
At least one of surfactant and the mixture of lauryl sodium sulfate；Preferably, the foaming agent is lauroyl flesh ammonia
At least one of sour sodium, sodium lauroylmethyl taurate and Cocoamidopropyl betaine and the mixing of lauryl sodium sulfate
Thing.
9. anti-caries toothpaste as claimed in claim 7, it is characterised in that the rubbing agent is precipitated silica, ultra-fine dioxy
At least one of SiClx, calcium monohydrogen phosphate and calcium carbonate；Preferably, the rubbing agent be precipitated silica, calcium monohydrogen phosphate and
The mixture of at least one of calcium carbonate and superfine silicon dioxide, wherein, it is ultra-fine in the preparing raw material of the anti-caries toothpaste
The weight percentage of silica is 2~6%.
10. anti-caries toothpaste as claimed in claim 7, it is characterised in that the thickener is sodium carboxymethylcellulose, carbomer
At least one of with xanthans；The NMF is at least one of D-sorbite, glycerine, polyethylene glycol and propane diols.
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| CN115844765A (en) * | 2022-11-25 | 2023-03-28 | 重庆医科大学附属口腔医院 | Antibacterial and anti-caries oral care composition and preparation method thereof |
| US11883520B2 (en) | 2019-06-14 | 2024-01-30 | The Procter & Gamble Company | Leave-on oral care compositions |
| US11904041B2 (en) | 2019-06-14 | 2024-02-20 | The Procter & Gamble Company | Leave-on oral care compositions |
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| CN107468553B (en) | 2020-08-07 |
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