CN107428758A - 丙烯酸类衍生物、其制备方法及其在医药上的用途 - Google Patents
丙烯酸类衍生物、其制备方法及其在医药上的用途 Download PDFInfo
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- CN107428758A CN107428758A CN201680020252.8A CN201680020252A CN107428758A CN 107428758 A CN107428758 A CN 107428758A CN 201680020252 A CN201680020252 A CN 201680020252A CN 107428758 A CN107428758 A CN 107428758A
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- heteroaryl
- heterocycle
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
本发明涉及一种通式(I)所示的丙烯酸类衍生物、其立体异构体、互变异构体或其可药用的盐，它们的制备方法，含有它们的药物组合物，以及它们作为治疗剂，特别是作为选择性雌激素受体下调剂(SERD)的用途，其中通式(I)各取代基与说明书中的定义相同。
Description
PCT国内申请，说明书已公开。
Claims (21)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510771111 | 2015-11-12 | ||
| CN2015107711117 | 2015-11-12 | ||
| PCT/CN2016/101768 WO2017080338A1 (zh) | 2015-11-12 | 2016-10-11 | 丙烯酸类衍生物、其制备方法及其在医药上的用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107428758A true CN107428758A (zh) | 2017-12-01 |
| CN107428758B CN107428758B (zh) | 2020-08-04 |
Family
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|---|---|---|---|
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Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10519148B2 (zh) |
| EP (1) | EP3378861B1 (zh) |
| JP (1) | JP6592197B2 (zh) |
| KR (1) | KR102099159B1 (zh) |
| CN (1) | CN107428758B (zh) |
| CA (1) | CA3011391C (zh) |
| TW (1) | TWI615393B (zh) |
| WO (1) | WO2017080338A1 (zh) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109311870A (zh) * | 2016-04-01 | 2019-02-05 | 芝诺罗耶尔蒂里程碑有限责任公司 | 雌激素受体调节剂 |
| CN109362222A (zh) * | 2016-02-05 | 2019-02-19 | 益方生物科技（上海）有限公司 | 选择性雌激素受体降解物及其用途 |
| WO2021228210A1 (zh) * | 2020-05-15 | 2021-11-18 | 江苏先声药业有限公司 | 吡咯烷类化合物及其应用 |
| US11278532B2 (en) | 2019-08-06 | 2022-03-22 | Recurium Ip Holdings, Llc | Estrogen receptor modulators for treating mutants |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3008020C (en) | 2015-12-09 | 2024-02-20 | The Board Of Trustees Of The University Of Illinois | Benzothiophene-based selective estrogen receptor downregulators |
| TW201803870A (zh) | 2016-04-20 | 2018-02-01 | 阿斯特捷利康公司 | 化學化合物 |
| WO2018001232A1 (zh) * | 2016-06-29 | 2018-01-04 | 浙江海正药业股份有限公司 | 丙烯酸类衍生物及其制备方法和其在医药上的用途 |
| WO2018019793A1 (en) | 2016-07-25 | 2018-02-01 | Astrazeneca Ab | N-(2-(4-((1r,3r)-3-methyl-2,3,4,9-tetrahydro-1h-pyrido[3,4-b]indol-1-yl)phenoxy)ethyl)propan-1-amine derivatives and related compounds as selective down-regulators of the estrogen receptor for treating cancer |
| CN107814798B (zh) * | 2016-09-14 | 2020-11-03 | 四川科伦博泰生物医药股份有限公司 | 3-取代丙烯酸类化合物及其制备方法和用途 |
| SI3640251T1 (sl) | 2016-10-24 | 2022-04-29 | Astrazeneca Ab | Derivati 6,7,8,9-tetrahidro-3H-pirazolo(4,3-f)izokinolina uporabni v zdravljenju raka |
| WO2018081168A2 (en) | 2016-10-24 | 2018-05-03 | The Board Of Trustees Of The University Of Illinois | Benzothiophene-based selective mixed estrogen receptor downregulators |
| EP3565558B1 (en) | 2017-01-06 | 2023-12-06 | G1 Therapeutics, Inc. | Combination therapy with a serd compound and a cdk4/6 inhibitor for the treatment of cancer |
| DK3494116T3 (da) | 2017-01-30 | 2020-01-27 | Astrazeneca | Østrogenreceptormodulatorer |
| AU2019229256A1 (en) | 2018-02-28 | 2020-09-17 | Ferro Therapeutics, Inc. | Compounds with ferroptosis inducing activity and methods of their use |
| US11040964B2 (en) | 2019-02-27 | 2021-06-22 | Ferro Therapeutics, Inc. | Compounds and methods of use |
| WO2020238733A1 (zh) | 2019-05-24 | 2020-12-03 | 浙江海正药业股份有限公司 | 丙烯酸类衍生物的晶型及其制备方法和用途 |
| CN110746340A (zh) * | 2019-11-07 | 2020-02-04 | 上海易恩化学技术有限公司 | 一种5-甲氧基-2-甲基色胺的合成方法 |
| CN116574054A (zh) * | 2023-05-15 | 2023-08-11 | 南京中医药大学 | 选择性雌激素受体下调剂化合物、制备方法及用途 |
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2016
- 2016-10-11 US US15/766,692 patent/US10519148B2/en active Active
- 2016-10-11 WO PCT/CN2016/101768 patent/WO2017080338A1/zh active Application Filing
- 2016-10-11 JP JP2018524291A patent/JP6592197B2/ja active Active
- 2016-10-11 EP EP16863515.9A patent/EP3378861B1/en active Active
- 2016-10-11 KR KR1020187014684A patent/KR102099159B1/ko active IP Right Grant
- 2016-10-11 CN CN201680020252.8A patent/CN107428758B/zh active Active
- 2016-10-11 CA CA3011391A patent/CA3011391C/en active Active
- 2016-10-25 TW TW105134387A patent/TWI615393B/zh active
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109362222A (zh) * | 2016-02-05 | 2019-02-19 | 益方生物科技（上海）有限公司 | 选择性雌激素受体降解物及其用途 |
| CN109362222B (zh) * | 2016-02-05 | 2021-03-19 | 益方生物科技(上海)股份有限公司 | 选择性雌激素受体降解物及其用途 |
| CN113004273A (zh) * | 2016-02-05 | 2021-06-22 | 益方生物科技(上海)股份有限公司 | 选择性雌激素受体降解物及其用途 |
| CN109311870A (zh) * | 2016-04-01 | 2019-02-05 | 芝诺罗耶尔蒂里程碑有限责任公司 | 雌激素受体调节剂 |
| US11065234B2 (en) | 2016-04-01 | 2021-07-20 | Recurium Ip Holdings, Llc | Estrogen receptor modulators |
| US11065233B2 (en) | 2016-04-01 | 2021-07-20 | Recurium Ip Holdings, Llc | Estrogen receptor modulators |
| CN109311870B (zh) * | 2016-04-01 | 2021-09-21 | 里科瑞尔姆Ip控股有限责任公司 | 雌激素受体调节剂 |
| CN113717170A (zh) * | 2016-04-01 | 2021-11-30 | 里科瑞尔姆Ip控股有限责任公司 | 雌激素受体调节剂 |
| US11278532B2 (en) | 2019-08-06 | 2022-03-22 | Recurium Ip Holdings, Llc | Estrogen receptor modulators for treating mutants |
| WO2021228210A1 (zh) * | 2020-05-15 | 2021-11-18 | 江苏先声药业有限公司 | 吡咯烷类化合物及其应用 |
| CN115836068A (zh) * | 2020-05-15 | 2023-03-21 | 先声药业有限公司 | 吡咯烷类化合物及其应用 |
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| US10519148B2 (en) | 2019-12-31 |
| EP3378861A1 (en) | 2018-09-26 |
| EP3378861A4 (en) | 2019-06-26 |
| TW201716406A (zh) | 2017-05-16 |
| CA3011391A1 (en) | 2017-05-18 |
| EP3378861B1 (en) | 2021-08-04 |
| CN107428758B (zh) | 2020-08-04 |
| WO2017080338A1 (zh) | 2017-05-18 |
| CA3011391C (en) | 2021-02-09 |
| JP2018535216A (ja) | 2018-11-29 |
| KR102099159B1 (ko) | 2020-04-10 |
| KR20180080245A (ko) | 2018-07-11 |
| TWI615393B (zh) | 2018-02-21 |
| JP6592197B2 (ja) | 2019-10-16 |
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