CN107412957B - A kind of photo-thermal therapy probe based on photo-thermal nano material - Google Patents
A kind of photo-thermal therapy probe based on photo-thermal nano material Download PDFInfo
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- CN107412957B CN107412957B CN201710565959.3A CN201710565959A CN107412957B CN 107412957 B CN107412957 B CN 107412957B CN 201710565959 A CN201710565959 A CN 201710565959A CN 107412957 B CN107412957 B CN 107412957B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/0625—Warming the body, e.g. hyperthermia treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0052—Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/067—Radiation therapy using light using laser light
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0626—Monitoring, verifying, controlling systems and methods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
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Abstract
The invention discloses a kind of, and the photo-thermal therapy based on photo-thermal nano material is popped one's head in; it includes cylinder-like shell closed at one end, the photo-thermal nano material for being filled in interior of shell closed end, the optical fiber for irradiating photo-thermal nano material and the temperature sensor for being tightly attached to closed termination of outer cover inner wall; the shell is hard material, provides the ability of protection internal components and tissue penetration；Laser is imported into probe inside by optical fiber；Luminous energy is converted to high temperature heat by photo-thermal nano material, and probe end temperature is monitored and controlled in temperature sensor.The present invention is nanomaterial-filled to interior of shell by photo-thermal, convert light energy into thermal energy, probe gets involved in lesion tissue position by minimally invasive, the efficient photothermal conversion mechanism for passing through photo-thermal nano material again implements high temperature and kills tumour and other pathological tissues cells, passes through the temperature of temperature sensor monitoring probe, it is simple with structure, easy to operate, wound face is small, treats efficient, accurate advantage.
Description
Technical field
The present invention relates to the field of medical instrument technology, for the device of minimally invasive invasive photo-thermal therapy, especially a kind of base
In photo-thermal nano material photo-thermal therapy pop one's head in, the probe can be used for treating human body different tissues organ tumour and other
Pathological tissues.
Background technique
The photo-thermal therapy that nano material mediates is that thermal energy is converted light energy by special nano material to pass through part
High temperature kills tumour and a kind of novel therapeutic means of other pathological tissues cells.In treatment, need nano material
It is administered by way of venous transfusion into the human body, photo-thermal nano material passes through blood circulation again and is enriched to lesions position, then
Pass through the photo-thermal therapy that laser irradiation lesions position implementation time and space are controllable.Currently, US and European had it is relevant
Photo-thermal nano material preparation enters clinical experimental stage.As described above, the precondition of photo-thermal therapy is by a certain amount of nanometer
Material injection is to human body, and each histoorgan that these nano materials can be distributed to human body by blood circulation includes lesion group
It knits, and can be even more long for a long time in human body delay, these nano material long-term existence can be brought in human body can not be pre-
The potential toxic side effect surveyed, this has become nano material toward the significant obstacle of clinical conversion.Photo-thermal nm probe passes through minimally invasive
The mode of intervention is inserted into lesion tissue position, and implements high temperature by photothermal conversion mechanism and kill pathological tissues cell.Currently, closing
In photo-thermal therapy probe patent include ZL96101822.4；The patent of ZL02286746.5, these photo-thermal probe will only swash
Light imported into pathological tissues position by transparent probe, these probes are not involved with photo-thermal applications to nanostructures, mechanism
It is to absorb luminous energy by lesion tissue to be then converted into thermal energy implementation treatment, the photothermal conversion efficiency of this mechanism is very low, cannot
Reach good therapeutic effect.
Summary of the invention
The purpose of the present invention is in view of the deficiencies of the prior art and provide a kind of photo-thermal based on photo-thermal nano material control
Probe is treated, which is integrated into photo-thermal probe inside for photo-thermal nano material, the efficient photo-thermal of photo-thermal nano material is utilized to turn
Change the Thermogenesis that function greatlys improve probe, and then improves the therapeutic efficiency of photo-thermal therapy probe.
Realizing the specific technical solution of the object of the invention is:
A kind of photo-thermal therapy probe based on photo-thermal nano material, feature is: the probe includes: cylindrical shape closed at one end
It shell, the photo-thermal nano material for being filled in interior of shell closed end, the optical fiber for irradiating photo-thermal nano material and is tightly attached to
The temperature sensor of closed termination of outer cover inner wall, the shell are hard material, provide the energy of protection internal components and tissue penetration
Power；Laser is imported into probe inside by optical fiber；Luminous energy is converted to high temperature heat by photo-thermal nano material, temperature sensor monitoring and
Control probe end temperature.
The cross-sectional outer diameter is 1-20 millimeters, and closed end is hemispherical or cone.
The hard material of the shell is stainless steel, copper or aluminium made of heat-conducting metal material, and shell exterior removes closed end
Outside optothermal material filling region, other regions coat heat-insulating material.
The shell consists of two parts, and closed end and optothermal material filling region are heat-conducting metal material, other
Part is heat-insulating material material.
The photo-thermal nano material is metal photo-thermal nano material, carbon nanomaterial, macromolecule polymer material or partly leads
Body nano material.
The metal photo-thermal nano material is gold nanosphere, gold nanorods, gold nanoshell, gold nanometer cage, gold-nano-piece, gold
Nanometer set square, gold nano star；Platinum nanosphere, platinum nanometer rods, platinum nanoshell, platinum nanocages, nano sheets of platinum, platinum nanometer triangle
Plate, platinum nanometer star；Palladium nanosphere, palladium nanometer rods, palladium nanoshell, palladium nanocages, palladium nano sheet, palladium nanometer set square or palladium nanometer
Star；The carbon nanomaterial is carbon quantum dot, carbon nanotube, graphene, graphene oxide or carbon dust；The high molecular polymer
Material is poly-dopamine nano particle or polypyrrole nano particle；The semiconductor nano material is copper sulfide, molybdenum sulfide, vulcanization
Bismuth, antimony trisulfide, aurosulfo copper selenide, selenizing molybdenum, bismuth selenide, antimony selenide or Auric selenide.
The wave crest of the absorption peak of the photo-thermal nano material is at 200-5000 nanometers；The size of the photo-thermal nano material exists
1-10000 nanometers.
The photo-thermal nano material for being filled in interior of shell closed end be dry powder, suspension, aeroge, hydrogel and
Solid state substrate；Wherein be dispersed in aeroge, hydrogel and solid state substrate is by physically trapping, adhesive gluing or chemistry
Key link.
The optic fibre end 1-2 centimeters for irradiating photo-thermal nano material are common direct light type optical fiber or pass through
The diffusion-type optical fiber that physics is milled or chemical attack is formed, common direct light type optical fiber head are placed in packed photo-thermal nano material,
Diffusion-type optical fiber is inserted into nano material bulk inner or is wrapped up by nano material.
The optical maser wavelength is at 200-5000 nanometers；Laser is continuous laser and pulse laser, and the power of laser is in 1-100
Watt.
The present invention arrives interior of shell for photo-thermal is nanomaterial-filled, converts light energy into thermal energy, probe passes through minimally invasive intervention
To lesion tissue position, then pass through the efficient photothermal conversion mechanism of photo-thermal nano material, implement high temperature and kill pathological tissues cell,
By the temperature of temperature sensor monitoring probe, have structure simple, easy to operate, wound face is small, and treatment is efficient, accurately excellent
Point.
Detailed description of the invention
Fig. 1 is the structural diagram of the present invention；
Fig. 2 is nanomaterial-filled 1 schematic diagram of structure type in closed end of photo-thermal of the present invention；
Fig. 3 is nanomaterial-filled 2 schematic diagram of structure type in closed end of photo-thermal of the present invention；
Fig. 4 is 1 egg white solution experimental data schematic diagram of the embodiment of the present invention, wherein a is temperature variation curve at any time
Figure；B is the thermograph in heating after five minutes；C is heating front and back solution state figure；
Fig. 5 is 2 mouse tumor model experimental data schematic diagram of the embodiment of the present invention, wherein a is the temperature at tumor focus position
Degree changes over time curve graph, and b is the thermograph in heating after ten minutes.
Specific embodiment
- Fig. 3 refering to fig. 1, the present invention include cylinder-like shell 1 closed at one end, the light for being filled in interior of shell closed end
Hot nano material 2, the optical fiber 3 for irradiating photo-thermal nano material and the temperature sensor 4 for being tightly attached to closed termination of outer cover inner wall,
The shell 1 is hard material, provides the ability of protection internal components and tissue penetration；Laser is imported into probe by optical fiber 3
Portion；Luminous energy is converted to high temperature heat by photo-thermal nano material 2, and probe end temperature is monitored and controlled in temperature sensor 4.
One end of shell of the present invention is equipped with end cap 5, and optical fiber 3 passes through the optic fibre hole 51 of end cap 5；The sensing of temperature sensor 4
The sensor contact pin holes 52 that device contact pilotage 41 passes through end cap 5 are inserted into the nanomaterial-filled region 12 of closed termination of outer cover and close to outer
1 inner wall of shell.
1 cross-sectional diameter of shell of the present invention is 1-20 millimeters, and closed end 11 is hemispherical or cone.It is removed outside shell 1
Outside closed end 11 and optothermal material filling region 12, other regions coat heat-insulating material 6(such as Fig. 1).Shell 1 or by two parts
Composition, closed end 11 and optothermal material filling region 12 are heat-conducting metal material, and other parts are heat-insulating material material (as schemed
1).
Photo-thermal nano material 2 of the invention is divided into two kinds in the filling mode of optothermal material filling region 12: one is fill out
The space of full optothermal material filling region 12, direct light type optical fiber 31 are placed in optothermal material top (such as Fig. 2), and another kind is along light
The inner wall of hot material filling region 12 is filled, and there are cylindrical cavity, diffusion-type optical fiber 32 to be placed in cavity (such as Fig. 3) at center.
When one end of optical fiber 3 of the present invention is direct light type 31, photo-thermal nano material 2 is filled in optothermal material filling region 12
(such as Fig. 2), laser by 3 end of optical fiber front directive photo-thermal nano material 2.
When one end of optical fiber 3 of the present invention is diffusion-type 32, photo-thermal nano material 2 is cylindrical to be distributed in optothermal material filling
Region 12(such as Fig. 3), laser is by diffusion-type 32 towards surrounding directive photo-thermal nano material 2.
The present invention uses lancet and means of the closed end 11 as skin tissue, and protects photo-thermal nano material 2 by shell 1
And optical fiber 3.Laser source is imported into optothermal material filling region 12 by optical fiber 3, then optical fiber 3 is absorbed by photo-thermal nano material 2
Luminous energy and be converted to thermal energy by probe 11 and the conduction of optothermal material filling region 12 to lesions position, and then realize the mesh for the treatment of
's.12 temperature of optothermal material filling region is monitored and controlled by temperature sensor 4.
The wave-length coverage of the laser source of optical fiber 3 of the invention is 200~5000 nanometers, and the waveform of laser source is continuous laser
Or pulse laser, the power of laser source are 1~100 watt.
The wave crest of the absorption peak of photo-thermal nano material 2 of the invention is 200~5000 nanometers, having a size of 1-10000 nanometers.
Embodiment 1
To egg white solution Heating Experiment
Photo-thermal nano material 2 of the present invention is selected to fill up the form in 12 space of optothermal material filling region, using the end of optical fiber 3
Head is direct light type 31(Fig. 2)；The region of end of probe 11 and 12 of the present invention is inserted into 1 milliliter of egg white solution, using laser
The continuous laser that the wavelength in source is 808 nanometers, it is 1 watt that laser, which projects power, and irradiation time is 10 minutes, is seen by Fig. 4, the reality
The temperature of probe surrounding egg white solution can effectively be increased by applying the bright present invention of illustration, and albumen protein is promoted to be denaturalized
(such as Fig. 4).
Embodiment 2
The experiment of tumour is killed in mouse tumor model
In order to further confirm that the present invention can be used for clinical treatment.Establish subcutaneous mouse tumor model.Select the present invention
Photo-thermal nano material 2 fills up the form in 12 space of optothermal material filling region, uses the end of optical fiber 3 for direct light type 31(Fig. 2)；
The region of end of probe 11 and 12 of the present invention is percutaneously inserted into tumour, then carrying out photo-thermal therapy, (it is 1 that laser, which projects power,
Watt, irradiation time is 5 minutes).Fig. 5 shows that tumor tissues lesions position can effectively heat in photo-thermal therapy probe, makes its temperature
Degree reaches 50 degrees Celsius or more, achievees the purpose that ablated tumor.
Claims (7)
1. a kind of photo-thermal therapy probe based on photo-thermal nano material, which is characterized in that the probe includes: cylinder closed at one end
Shape shell, the photo-thermal nano material for being filled in interior of shell closed end, the optical fiber for irradiating photo-thermal nano material and abutting
In the temperature sensor of closed termination of outer cover inner wall, the shell is hard material, provides protection internal components and tissue penetration
Ability；Laser is imported into probe inside by optical fiber；Luminous energy is converted to high temperature heat, temperature sensor monitoring by photo-thermal nano material
With control probe end temperature；Wherein:
The optic fibre end 1-2 centimeters for irradiating photo-thermal nano material are that common direct light type optical fiber either passes through physics
It mills or the diffusion-type optical fiber of chemical attack formation, common direct light type optical fiber head is placed in packed photo-thermal nano material, disperse
Type optical fiber is inserted into nano material bulk inner or is wrapped up by nano material；
The wave crest of the absorption peak of the photo-thermal nano material is at 200-5000 nanometers；The size of the photo-thermal nano material is in 1-
10000 nanometers；
The optical maser wavelength is at 200-5000 nanometers；Laser is continuous laser or pulse laser, and the power of laser is at 1-100 watts.
2. photo-thermal therapy probe according to claim 1, which is characterized in that the cross-sectional outer diameter is 1-20 milli
Rice, closed end are hemispherical or cone.
3. photo-thermal therapy probe according to claim 1, which is characterized in that the hard material of the shell is heat-conducting metal
Stainless steel, copper made of material or aluminium, shell exterior is in addition to closed end and optothermal material filling region, the cladding insulation of other regions
Material.
4. photo-thermal therapy probe according to claim 1, which is characterized in that the shell consists of two parts, closed end
It is heat-conducting metal material with optothermal material filling region, other parts are heat-insulating material material.
5. photo-thermal therapy probe according to claim 1, which is characterized in that the photo-thermal nano material is that metal photo-thermal is received
Rice material, carbon nanomaterial, macromolecule polymer material or semiconductor nano material.
6. photo-thermal therapy probe according to claim 5, which is characterized in that the metal photo-thermal nano material is gold nano
Ball, gold nanorods, gold nanoshell, gold nanometer cage, gold-nano-piece, gold nano set square, gold nano star, platinum nanosphere, platinum nanometer
Stick, platinum nanoshell, platinum nanocages, nano sheets of platinum, platinum nanometer set square, platinum nanometer star, palladium nanosphere, palladium nanometer rods, palladium nanometer
Shell, palladium nanocages, palladium nano sheet, palladium nanometer set square or palladium nanometer star；The carbon nanomaterial is carbon quantum dot, carbon nanometer
Pipe, graphene, graphene oxide or carbon dust；The macromolecule polymer material is poly-dopamine nano particle or polypyrrole nanometer
Particle；The semiconductor nano material is copper sulfide, molybdenum sulfide, bismuth sulfide, antimony trisulfide, aurosulfo copper selenide, selenizing molybdenum, selenizing
Bismuth, antimony selenide or Auric selenide.
7. photo-thermal therapy probe according to claim 1, which is characterized in that the light for being filled in interior of shell closed end
Hot nano material is dry powder, suspension, aeroge, hydrogel or solid state substrate；Wherein it is dispersed in aeroge, hydrogel and solid-state
Photo-thermal nano material in matrix is by physically trapping, adhesive gluing or chemical bond linkage.
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1498600A (en) * | 2002-11-04 | 2004-05-26 | 中国科学院福建物质结构研究所 | Laseer heat treatment appliance for treating tumour |
| CN203494072U (en) * | 2013-09-27 | 2014-03-26 | 大连海事大学 | Photo-thermal tumor-removing device |
| CN104840358A (en) * | 2015-05-07 | 2015-08-19 | 上海大学 | Laser thermotherapy acupuncture needle with optical fibers |
| CN104840251A (en) * | 2015-05-07 | 2015-08-19 | 上海大学 | Laser thermal therapy probe based on photothermal effect of optical fiber material |
| CN105664158A (en) * | 2016-01-07 | 2016-06-15 | 复旦大学 | Photoluminescence-photothermal nano composite structural material and preparation method and application thereof |
| CN106853248A (en) * | 2015-12-09 | 2017-06-16 | 首都师范大学 | A kind of photo-thermal composite nano materials and preparation method and application |
| CN106902350A (en) * | 2017-02-21 | 2017-06-30 | 东南大学 | A kind of metal-doped photo-thermal carbon nanomaterial and its preparation method and application |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4221364A1 (en) * | 1992-06-29 | 1994-01-05 | Raimund Dr Kaufmann | Body tissue heating probe |
| US20050203496A1 (en) * | 2004-03-12 | 2005-09-15 | Ritchie Paul G. | Medical apparatus and method useful for thermal treatment of a lumen |
| US20160008624A1 (en) * | 2014-07-11 | 2016-01-14 | Jessica D Grossman | Devices and methods for treatment inside a body cavity |
| CN107205771A (en) * | 2014-09-15 | 2017-09-26 | 诺服塞尔有限公司 | The method and apparatus for being vaporized for thermosurgery and cutting tissue |
| KR101776847B1 (en) * | 2015-02-17 | 2017-09-11 | 연세대학교 원주산학협력단 | Minimally invasive laser needle system for treatment of Arthritis |
| CN107835671B (en) * | 2015-07-14 | 2021-07-23 | 波士顿科学医学有限公司 | Cautery devices, methods and systems |
| CN106362152A (en) * | 2016-11-21 | 2017-02-01 | 湖北工业大学 | Material for tumor photothermic treatment and preparation method and application thereof |
-
2017
- 2017-07-12 CN CN201710565959.3A patent/CN107412957B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1498600A (en) * | 2002-11-04 | 2004-05-26 | 中国科学院福建物质结构研究所 | Laseer heat treatment appliance for treating tumour |
| CN203494072U (en) * | 2013-09-27 | 2014-03-26 | 大连海事大学 | Photo-thermal tumor-removing device |
| CN104840358A (en) * | 2015-05-07 | 2015-08-19 | 上海大学 | Laser thermotherapy acupuncture needle with optical fibers |
| CN104840251A (en) * | 2015-05-07 | 2015-08-19 | 上海大学 | Laser thermal therapy probe based on photothermal effect of optical fiber material |
| CN106853248A (en) * | 2015-12-09 | 2017-06-16 | 首都师范大学 | A kind of photo-thermal composite nano materials and preparation method and application |
| CN105664158A (en) * | 2016-01-07 | 2016-06-15 | 复旦大学 | Photoluminescence-photothermal nano composite structural material and preparation method and application thereof |
| CN106902350A (en) * | 2017-02-21 | 2017-06-30 | 东南大学 | A kind of metal-doped photo-thermal carbon nanomaterial and its preparation method and application |
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