CN107411995A - A kind of oral-cavity article containing sodium azulenesulfonate and preparation method thereof - Google Patents
A kind of oral-cavity article containing sodium azulenesulfonate and preparation method thereof Download PDFInfo
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- CN107411995A CN107411995A CN201710155356.6A CN201710155356A CN107411995A CN 107411995 A CN107411995 A CN 107411995A CN 201710155356 A CN201710155356 A CN 201710155356A CN 107411995 A CN107411995 A CN 107411995A
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- sodium azulenesulfonate
- dipotassium glycyrrhizinate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The invention discloses a kind of oral-cavity article containing sodium azulenesulfonate, its raw material is mainly made up of sodium azulenesulfonate, dipotassium glycyrrhizinate and potassium nitrate, and the mass fraction of its raw material is respectively：0.001~3 part of sodium azulenesulfonate, 0.01~8 part of dipotassium glycyrrhizinate, 0.01~10 part of potassium nitrate.The technical problem to be solved in the present invention is to provide optimal a kind of oral-cavity article containing sodium azulenesulfonate of a kind of antibacterial and anti-sensitizing effect and preparation method thereof.
Description
Technical field
The present invention relates to dentistry to configure product technical field, and in particular to a kind of oral-cavity article and its preparation containing sodium azulenesulfonate
Method.
Background technology
Oral cavity is a window for visiting general body state, and mouth disease is handled not in time can trigger a variety of concurrent of body
Disease, with the improvement of living standards, increasing people starts to pay attention to oral health.Common mouth disease have canker sore,
Periodontosis and carious tooth.Canker sore is a kind of sex-limited ulcer of oral mucosa office canker sore with the characteristics of cyclical recurrent
Damage, can occur at any position of oral mucosa, and clinical symptoms show as slow, the oral cavity evil that salivates, loses the appetite or search for food
It is smelly, mucous membrane of mouth flush, heat, swelling and pain.Periodontosis refers mainly to gingivitis and periodontitis；Gingivitis refers to occur in tooth
Acute, the chronic inflammation of gum tissue, common manifestation are bleeding gums, red and swollen, distending pain, also result in the hair repeatedly of canker sore
Make, both can also interact, and form vicious circle, if being possible to cause periodontal to Deep Development without effectively treatment
Inflammation, the problem of causing tooth mobility, loss of tooth etc. more serious.Periodontitis is to invade the chronic inflammation of gum and periodontium,
It is a kind of destructive disease, it is more because bacterial plaque, dental calculus, food impaction, ill fitting prosthesis, stinging wound etc. and causing various focusing depths represented to swell
It is swollen, the larger Periodontal Pathogens of a large amount of virulence are grown in bacterial plaque, the increased inflammation and expansion for making gum prolong, and cause periodontal bag formation
And absorption of alveolar bone, cause periodontitis.And gingival atrophy, wedge-shaped defect, carious tooth and bruxism will also result in sensitivity of tooth, tooth
Sensitivity is the clinical manifestation of multiple oral disease, is caused more by enamel abrasion conjunction, dentine exposure, at present, sensitivity of tooth is same
Sample is a kind of common oral problem of adult.
Sodium azulenesulfonate is the abbreviation of Kessazulen sodium sulfonate, and its chemistry is entitled：1.4-dimethyl-7-isopropyl Azulene-
3-sodium sulfonate.Its parent compound is Azulene, and Kessazulen is its alkyl-substituted derivative.Azulene and its derivative are non-benzene carbon
Cyclophane aroma compounds, though it is weak compared with benzene series aromatic compound armaticity, but still electrophilic substitution reaction can occur on ring.Alkyl takes
For Azulene, especially 1.4 are methyl, and 7 are that the compound of ethyl or isopropyl has stronger bioactivity, have anti-inflammatory, promote
The effects such as granulation regeneration.It is not soluble in water because it is a kind of blue grease, limit its application in medicine.Therefore, to it
Chemical constitution transformation is carried out, introduces chemical group, increase is water-soluble, and this purple is obtained during water-soluble Azulene is prepared
Active component.The composition has the effect such as antibacterial, antiallergy and function of tissue regeneration, and security is again high, therefore has begun to
Applied to medicine, health products and cosmetics, and in developed countries such as Japan, Europe, sodium azulenesulfonate has started to produce in oral care
Used in product.
Publication number CN101062005 patent discloses a kind of medicated toothpaste containing sodium azulenesulfonate.Publication number
CN102283949A patent discloses a kind of spraying agent for ulcer of oral cavity containing sodium azulenesulfonate, including：Sodium azulenesulfonate, benzene assistant card
Cause, Chinese medical extract, purified water, ethanol and sweetener.Publication number CN102160886A patent is disclosed containing sodium azulenesulfonate
With the compound buccal tablet of herbal mixture, the treatment for inflammation in oral cavity.Publication number CN102600122A patent discloses one
Mouth paster of the kind containing Glu and sodium azulenesulfonate.The A of publication number CN 103550102 patent discloses one kind and contains field
The Chinese herbal toothpaste of seven total saposins and Kessazulen sodium sulfonate.Publication number CN 104983844A patent is disclosed with mucous membrane
The composite formula of repair function and its preparation process of preparation, composition include sodium azulenesulfonate, chitosan, Rosa roxburghii fruit powder.It is public
The number of opening CN 105748385A patent discloses a kind of improvement gum blood circulation, safeguards periodontal and the tooth of mucous membrane of mouth health
Cream, including Radix Sophorae Flavescentis extractive liquid, rhizoma imperatae extract solution, French yellow chamomile extract solution, sodium azulenesulfonate etc..Publication number CN105123353A
Patent disclose compound oral film and preparation method containing sodium azulenesulfonate.Publication number CN104644460A patent discloses
A kind of medicated toothpaste composition and its production and use, including Kessazulen sodium sulfonate, Paeonol, allantoin and ammonia first
Naphthenic acid.Publication number CN101590005 patent discloses biological nursing composition toothpaste, including sodium azulenesulfonate, radix notoginseng extraction
Liquid, SOD organized enzymes and biological lysozyme.Publication number CN105031614A patent discloses a kind of Anhydroalkannin and alleviates ulcer
Oral care composition and its application, including sodium azulenesulfonate and EGF.
Sodium azulenesulfonate is pure plant extracts, has Nonsteroidal anti-inflammatory effect and anti-mucosal ulcer effect, can promote mucous membrane
Metabolism, promote epidermal growth, enjoy modern to favor.But study and find according to inventor, sodium azulenesulfonate is used alone anti-
Bacterium ability is weaker and without the effect of anti-sensitivity of tooth, and therefore, sodium azulenesulfonate, which is individually added into, can not effectively suppress to cause oral cavity disease
The bacterium of disease, alleviate a variety of oral problems such as gingivitis and sensitivity of tooth, in order to solve this problem, in the patent of the above it is many
It is the toothpaste with good anti-bacterial effect that toothpaste and various Chinese herbal medicines are cooperatively formed to compounding.
Dipotassium glycyrrhizinate is white or off-white color fine powder, and purity has a special sweet taste up to 98%, it is water-soluble it is good, mouthfeel is pure, tool
There are the multiple efficacies such as antibacterial, anti-inflammatory, removing toxic substances, antiallergic, deodorization；The tubule that potassium ion in potassium nitrate enters dentine can reduce tooth
The permeability of essence, and have affinity interaction with nerve endings, improve the transmission of nerve impulse, reach alleviation dental pain, treat
Sensitivity of tooth etc. acts on.
Although sodium azulenesulfonate and dipotassium glycyrrhizinate are the raw materials commonly used in toothpaste, not sodium azulenesulfonate at present
The oral cavity composition combined with dipotassium glycyrrhizinate, therefore, inventor is during research and development, to sodium azulenesulfonate, dipotassium glycyrrhizinate
Combination matching studied, the antibacterial and therapeutic effect of antiallergic sense being optimal.
The content of the invention
The technical problem to be solved in the present invention is to provide the optimal one kind of a kind of antibacterial and anti-sensitizing effect to contain sodium azulenesulfonate
Oral-cavity article and preparation method thereof.
In order to solve the above-mentioned technical problem, the present invention provides following technical scheme：A kind of oral-cavity article containing sodium azulenesulfonate,
Its raw material is mainly made up of sodium azulenesulfonate, dipotassium glycyrrhizinate and potassium nitrate, and the mass fraction of its raw material is respectively：Sodium azulenesulfonate
0.001~3 part, 0.01~8 part of dipotassium glycyrrhizinate, 0.01~10 part of potassium nitrate.
Using a kind of oral-cavity article containing sodium azulenesulfonate of technical solution of the present invention, inventor has found under study for action, Azulene sulphur
The cooperation of both sour sodium and dipotassium glycyrrhizinate, and it is unable to reach that effect is optimal, and pass through the proportioning of three after potassium nitrate is added
Relation adjusts, and can reach that effect is optimal, and it is in nonlinear trend that its three, which can reach the optimal proportion relation of effect, therefore,
After inventor has done substantial amounts of experimental study, obtained proportion relation as above, compared to do not add sodium azulenesulfonate, sodium azulenesulfonate and
Dipotassium glycyrrhizinate mixture, sodium azulenesulfonate and dipotassium glycyrrhizinate and with for the comparative example oral-cavity article of mixture of potassium nitrate, tool
There is more excellent antibacterial, antiallergic sense effect.
Further, its product is toothpaste.
Further, its product is mouthwash.
Further, its product is tooth powder.
Further, the mass fraction of the raw material of its toothpaste is：0.001 part of sodium azulenesulfonate, 0.01 part of dipotassium glycyrrhizinate, nitric acid
0.01 part of potassium；
Or 0.03 part of sodium azulenesulfonate, 0.1 part of dipotassium glycyrrhizinate, 0.3 part of potassium nitrate；
Or 0.03 part of sodium azulenesulfonate, 0.5 part of dipotassium glycyrrhizinate, 3 parts of potassium nitrate；
Or 0.1 part of sodium azulenesulfonate, 0.5 part of dipotassium glycyrrhizinate, 3 parts of potassium nitrate；
Or 0.1 part of sodium azulenesulfonate, 0.5 part of dipotassium glycyrrhizinate, 0.5 part of potassium nitrate.
Further, the mass fraction of the raw material of its mouthwash is：0.01 part of sodium azulenesulfonate, 0.1 part of dipotassium glycyrrhizinate, nitric acid
0.3 part of potassium；
Or 0.01 part of sodium azulenesulfonate, 0.3 part of dipotassium glycyrrhizinate, 1 part of potassium nitrate；
Or 0.08 part of sodium azulenesulfonate, 0.3 part of dipotassium glycyrrhizinate, 1 part of potassium nitrate；
Or 0.08 part of sodium azulenesulfonate, 0.3 part of dipotassium glycyrrhizinate, 0.5 part of potassium nitrate.
Further, the mass fraction of the raw material of its tooth powder is：0.03 part of sodium azulenesulfonate, 0.1 part of dipotassium glycyrrhizinate, potassium nitrate
0.3 part；
Or 0.03 part of sodium azulenesulfonate, 0.3 part of dipotassium glycyrrhizinate, 1 part of potassium nitrate；
Or 0.1 part of sodium azulenesulfonate, 0.3 part of dipotassium glycyrrhizinate, 1 part of potassium nitrate；
Or 0.1 part of sodium azulenesulfonate, 0.3 part of dipotassium glycyrrhizinate, 0.5 part of potassium nitrate.
Further, the purity of described sodium azulenesulfonate is more than 98%.
Further, its product also includes tooth gel or chewing gum.
The preparation method of toothpaste in oral-cavity article containing sodium azulenesulfonate, its operating procedure include：
The first step, NMF glycerine is added, adhesive sodium carboxymethylcellulose is added, quickly stirs homogeneous, then successively
Add sweetener sorbierite, saccharin sodium, sodium azulenesulfonate, dipotassium glycyrrhizinate, potassium nitrate, Surfactant SDS,
Preservative sodium benzoate, and uniform stirring；
Second step, vacuumize and add rubbing agent silica, stir homogeneous；
3rd step, essence Mint Essence is added, stir homogeneous, degassing, toothpaste completes.
Embodiment
First, a kind of oral-cavity article toothpaste containing sodium azulenesulfonate of the present invention, raw material and its quality such as institute of table 1 of each embodiment
Show, unit：G,
Table 1
A kind of oral-cavity article toothpaste containing sodium azulenesulfonate of the present invention, the raw material and its quality of comparative example are as shown in table 2, single
Position：g：
Table 2
By taking embodiment 1 as an example, a kind of specifically preparation method of bright oral-cavity article toothpaste containing sodium azulenesulfonate：
Embodiment 1：
The first step, NMF glycerine 10g is added, adhesive sodium carboxymethylcellulose 0.7g is added, quickly stirs homogeneous,
Sequentially add sweetener sorbierite 35g, saccharin sodium 0.4g, sodium azulenesulfonate 0.001g, dipotassium glycyrrhizinate 0.01g, potassium nitrate
0.01g, Surfactant SDS 2g, preservative sodium benzoate 0.3g, and uniform stirring；
Second step, vacuumize and add rubbing agent silica 24g, stir homogeneous；
3rd step, essence Mint Essence 1g is added, stir homogeneous, degassing, toothpaste completes.
2~embodiment of embodiment 8,1~comparative example of comparative example 7, its preparation method except table 1, table 2 difference in addition to, its
It is remaining consistent.
Experiment one：Bacteriostatic test
Candida albicans (C.a) can cause thrush, canker sore etc., and porphyromonas gingivalis (P.g) is to trigger periodontal
Scorching main bacteria, using disk diffusion method assess table 1,1~embodiment of embodiment 8 of table 2,1~comparative example of comparative example 7 tooth
Antibacterial potentiality of the cream to Candida albicans and porphyromonas gingivalis.Operating procedure is as follows：It is 1.5 by the concentration that cultivation has P.g
×106CFU/mL bacteria suspensions are applied on BHIA with oese picking uniform crossover, totally 15.It is 1.0 by the concentration that cultivation has C.a
×107Cells/mL bacteria suspensions are applied on Sabouraud glucose agar with oese picking uniform crossover, totally 15.Respectively
15 kinds of experiment toothpaste are spread evenly across on a diameter of 6mm roundlet filter paper with paste about 50mg, every kind of 6, toothpaste.It will apply
A kind of roundlet filter paper of toothpaste of cloth is divided into two groups, and each flat board pastes 3 of same toothpaste, then pastes negative control and the positive is right
According to each a piece of, every group of middle section (every kind of each culture medium of bacterium) being attached at respectively on culture medium symmetrically.Most
Culture dish is placed in 37 DEG C of constant temperature incubator afterwards and result is observed after 24h, determine antibacterial circle diameter.3 repeated experiments, with 3
Secondary average value is bacteriostatic diameter.As a result it is as shown in table 3：
Table 3
As shown in Table 3, first, 1~embodiment of embodiment 8, with the dosage of sodium azulenesulfonate, dipotassium glycyrrhizinate and potassium nitrate
Gradually increase, fungistatic effect are incremental；Second, 1~comparative example of comparative example 5, sodium azulenesulfonate, dipotassium glycyrrhizinate and potassium nitrate are not added
Any one raw material, its antibacterial effect is under embodiment 4；3rd, either embodiment or comparative example, in embodiment
Continue to increase any of which raw material on 4 sodium azulenesulfonate, dipotassium glycyrrhizinate and nitric acid potassium application rate, its fungistatic effect changes not
It is notable again, it can be seen that, the raw material proportioning of the present embodiment 4 is most appropriate.
Experiment two：Clinical test
Clinical oral test, choosing are carried out to the toothpaste of table 1,1~embodiment of embodiment 8 of table 2,1~comparative example of comparative example 7
Take with canker sore, the bleeding of gum redness, the people of sensitivity of tooth, every group of 20 people.They are (every on the basis of daily habits
It brushes tooth twice) respectively using the toothpaste of 1~embodiment of embodiment 8 and 1~comparative example of comparative example 7, continue one week, and observe three
Recurrence after individual month, as a result as shown in table 4：
Table 4
From the point of view of the stability of toothpaste, lotion exquisiteness, the stability of 1~embodiment of embodiment 6 are preferable, do not separate
Water outlet, dry and hard situations such as hardening, there is slight separation water outlet phenomenon in embodiment 7, embodiment 8, but have no effect on use；It is and right
Ratio 6,7,9 occurs separating water outlet, the situation of shelling, and formulation stability is poor, influences to use.
It was found from from the stability result of table 4 and toothpaste, the proportion relation of composition determines therapeutic effect, 1. embodiment 1
The therapeutic effect of~embodiment 8 is significantly better than the therapeutic effect of 1~comparative example of comparative example 7；2. 3~embodiment of embodiment 5 is steady
It is qualitative it is optimal, effect is best；3. although the effect of embodiment 1, embodiment 2, embodiment 6, embodiment 7, embodiment 8 is better than contrast
1~comparative example of example 7, but its stability is slightly worse, but have no effect on use；4. pass through embodiment 4 and 2~comparative example of comparative example 4
Result show, the addition of potassium nitrate, more preferable effect can be reached；Under same ratio, even if only adding one less in toothpaste
Kind component, effect also differ greatly, and this, which just illustrates that sodium azulenesulfonate, dipotassium glycyrrhizinate and potassium nitrate composition coordinate, effectively to control
Treat canker sore, alleviate the symptom of sensitivity of tooth and gingivitis, three only with the use of when, best results, and three months
Do not recur substantially afterwards；It is not to add 5. can be seen that from the proportion relation and experimental result of embodiment 3,4,5,6, the cooperation of three
Amount is bigger, and effect is more excellent, but has mutual matching relationship, for example, embodiment 3,4, although the addition of sodium azulenesulfonate is different,
But identical effect can be reached, embodiment 5,6, the amount of three's raw material adds, but effect but substantially reduces.Implement
1~embodiment of example 8, only it is the effect preferably embodiment that inventor chooses in embodiment, and during research and development.
It is visible with reference to table 3, table 4, for 1~embodiment of embodiment 8, although with dosage increase fungistatic effect by
Cumulative to add, still, during clinic trial, because dosage is more, its excitant to oral cavity is also most strong, so as to have impact on
Actual therapeutic effect, therefore, the best results of embodiment 3~5.
2nd, a kind of oral-cavity article mouthwash containing sodium azulenesulfonate of the present invention, raw material and its quality such as institute of table 5 of each embodiment
Show, unit：G,
Table 5
A kind of oral-cavity article mouthwash containing sodium azulenesulfonate of the present invention, the raw material and its quality of its comparative example are as shown in table 6,
Unit：G,
Table 6
Now illustrated with a kind of embodiment 9 of the oral-cavity article mouthwash containing sodium azulenesulfonate of the present invention, illustrate the system of the present invention
Preparation Method：
Preparation process is：
The first step：NMF glycerine 5.5g, water 79.289g, sweetener neotame 0.2g are first mixed into aqueous phase,
Second step：Still further add sodium azulenesulfonate 0.001g, dipotassium glycyrrhizinate 0.01g, potassium nitrate 0.01g, Mint Essence
1g, sorbierite 12g, poloxamer 2g are mixed to after without muddy shape, and aqueous phase is slowly added to during stirring, filtering packing, is gargled
Prepared by saliva completes.
Experiment one：Bacteriostatic test
Select Candida albicans and porphyromonas gingivalis to table 5,9~embodiment of embodiment 16 of table 6, comparative example 8~
The mouthwash of comparative example 14 carries out bacteriostatic experiment, experimental method according to《Disinfection technology standard》2.1.8.2 being operated, take three times
Repeating experiment has the average value of inhibition zone diameter of bacteriostasis, as a result as shown in table 7：
Table 7
As shown in Table 7, first, 9~embodiment of embodiment 16, with the use of sodium azulenesulfonate, dipotassium glycyrrhizinate and potassium nitrate
Gradually increase, fungistatic effect are incremental for amount；Second, 8~comparative example of comparative example 12, sodium azulenesulfonate, dipotassium glycyrrhizinate and nitre are not added
Any one raw material of sour potassium, its antibacterial effect is under embodiment 12；3rd, either embodiment or comparative example,
Continue to increase any of which raw material, its antibacterial effect on the sodium azulenesulfonate of embodiment 12, dipotassium glycyrrhizinate and nitric acid potassium application rate
Fruit change is no longer notable, it can be seen that, the raw material proportioning of the present embodiment 12 is most appropriate.
Experiment two：Clinical test
Clinical oral test is carried out to the mouthwash of 9~embodiment of embodiment 16 and 8~comparative example of comparative example 14, chooses and suffers from
There are canker sore, gingivitis, the people of sensitivity of tooth, every group of 20 people.They (gargle three daily on the basis of daily habits
It is secondary) respectively using the mouthwash of 9~embodiment of embodiment 16 and 8~comparative example of comparative example 14, continue one week, and observe three months
Recurrence afterwards, as a result as shown in table 8：
Table 8
It can be drawn from table 8,1. the proportion relation of composition determines therapeutic effect, the treatment effect of 9~embodiment of embodiment 16
Fruit is significantly better than the therapeutic effect of 8~comparative example of comparative example 14, and 2. the effect of 10~embodiment of embodiment 13 is best；3. pass through implementation
The result of example 12 and 9~comparative example of comparative example 11 shows, the addition of potassium nitrate, can preferably alleviate canker sore and gingivitis
Symptom, under same ratio, though in mouthwash only add a kind of component less, effect also differs greatly, and this just illustrates Azulene sulphur
Sour sodium, dipotassium glycyrrhizinate and potassium nitrate composition can effectively treat canker sore, alleviate the symptom of sensitivity of tooth and gingivitis, and three
Person only with the use of when, best results, and not recurred substantially after three months；4. from the proportioning of embodiment 11,12,13,14
Relation and experimental result can be seen that, the cooperation of three, be not that the bigger effect of dosage is more excellent, but have mutual matching relationship,
For example, embodiment 11,12, although the addition of sodium azulenesulfonate is different, identical effect can be reached, embodiment 13,14,
The amount of three's raw material adds, but effect but substantially reduces.
It is visible with reference to table 7, table 8, for 9~embodiment of embodiment 16, although the increase fungistatic effect with dosage
Gradually increase, still, during clinic trial, because dosage is more, its excitant to oral cavity is also most strong, so as to influence
Actual therapeutic effect, therefore, the best results of embodiment 11~13.
3rd, in each embodiment of the tooth powder of the composition containing sodium azulenesulfonate raw material composition and quality, unit g, such as table 9 and table
Shown in 10：
Table 9
Table 10
Illustrated with embodiment 17, illustrate the preparation method of tooth powder, preparation process is：First by calcium carbonate 79.979g, carbon
Sour hydrogen sodium 8g, saccharin sodium 0.5g, Herba Menthae powder essence 0.5g, Natural menthol 1g are ground into fine powder and cross 250 mesh sieves, then by Azulene sulfonic acid
Sodium powder 0.001g, dipotassium glycyrrhizinate 0.01g, potassium nitrate 0.01g are made after powder crosses 300 mesh sieves, with aforementioned mixture and dodecane
Base sodium sulphate 10g is well mixed, and finally, dispenses every part of 10g~50g, prepared by tooth powder completes.
Experiment one：Bacteriostatic test
Candida albicans and porphyromonas gingivalis are selected to table 9,17~embodiment of embodiment 24 of table 10, comparative example 15
The toothpaste of~comparative example 21 carries out bacteriostatic experiment, and experimental method is:5g tooth powder is weighed respectively, and it is sterile to add 50mL after mortar grinder
Distilled water, uniform dispersion is made；It is 1.5 × 10 by the concentration that cultivation has P.g6CFU/mL bacteria suspensions are uniform with oese picking
Intersection is applied on BHIA, totally 15.It is 1.0 × 10 by the concentration that cultivation has C.a7Cells/mL bacteria suspensions are equal with oese picking
Even intersection is applied on Sabouraud glucose agar, totally 15.Aseptic nipper gripping filter paper immerses above-mentioned tooth powder point respectively
In dispersion liquid, surplus liquid is removed in beaker inwall, the scraps of paper are checked the number to be pasted into and are inoculated with the flat board for examination bacterium by sterile working, then are pasted
Negative control and positive control are each a piece of, every group of middle section (every kind of bacterium being attached at symmetrically respectively on culture medium
Each culture medium).Finally culture dish is placed in 37 DEG C of constant temperature incubator and result is observed after 24h, determine antibacterial circle diameter.
3 repeated experiments, using 3 average values as bacteriostatic diameter.As a result it is as shown in table 11：
Table 11
As shown in Table 11, first, the fungistatic effect of 17~embodiment of embodiment 24 is except the effect of embodiment 17 is less than contrast
Exception, remaining embodiment are significantly better than that 15~comparative example of comparative example 21；Second, 17~embodiment of embodiment 24, with Azulene sulphur
The dosage of sour sodium, dipotassium glycyrrhizinate and potassium nitrate gradually increases, and fungistatic effect is incremental；3rd, the phase of 18~comparative example of comparative example 21
For embodiment 20, sodium azulenesulfonate, dipotassium glycyrrhizinate and potassium nitrate produce change, but from the results of view, no matter appointing in three
A kind of raw material dosage of anticipating is improved or reduced, and its antibacterial effect is under embodiment 20, it can be seen that, the original of the present embodiment 20
Material proportioning is most appropriate.
Experiment two：Clinical test
Clinical oral test is carried out to the tooth powder of 17~embodiment of embodiment 24 and 15~comparative example of comparative example 21, chooses and suffers from
There are canker sore, gingivitis, the people of sensitivity of tooth, every group of ten people.They (brush the teeth twice daily) on the basis of daily habits
Respectively using the tooth powder of 17~embodiment of embodiment 24 and 15~comparative example of comparative example 21, continue one week, and after observation three months
Recurrence.
As a result such as table 12：
Table 12
It can be drawn from table 12,1. the proportion relation of composition determines therapeutic effect, the treatment of 17~embodiment of embodiment 24
Positive effect is better than the therapeutic effect of 15~comparative example of comparative example 21；2. the effect of 18~embodiment of embodiment 22 is best；3. pass through
The result of embodiment 21 and 16~comparative example of comparative example 18 shows, the addition of potassium nitrate, can preferably alleviate canker sore and
The symptom of gingivitis, under same ratio, even if only adding a kind of component less in tooth powder, effect also differs greatly, and this just illustrates
Sodium azulenesulfonate powder, zinc citrate and potassium nitrate composition can effectively treat canker sore, alleviate the disease of sensitivity of tooth and gingivitis
Shape, three only with the use of when, best results, and not recurred substantially after three months；4. from embodiment 19,20,21,22
Proportion relation and experimental result can be seen that, the cooperation of three, be not that the bigger effect of dosage is more excellent, but have mutual cooperation to close
System, for example, embodiment 19,20, although the addition of sodium azulenesulfonate is different, identical effect can be reached, embodiment 21,
22, the amount of three's raw material adds, but effect but substantially reduces.
It is visible with reference to table 11, table 12, for 17~embodiment of embodiment 24, although with the antibacterial effect of the increase of dosage
Fruit gradually increases, and still, during clinic trial, because dosage is more, its excitant to oral cavity is also most strong, so as to shadow
The therapeutic effect of reality, therefore, the best results of embodiment 19~21 are rung.
From secondary, a kind of oral-cavity article containing sodium azulenesulfonate of the invention, toothpaste, mouthwash, tooth powder sodium azulenesulfonate,
Dipotassium glycyrrhizinate and potassium nitrate are coordinated with suitable ratio, can reach optimal antibacterial, antiallergic effect.
For those skilled in the art, toothpaste, mouthwash, tooth powder are considered technical solution of the present invention and are relatively applicable
Oral-cavity article, but the present invention is not limited in being added into toothpaste, mouthwash, tooth powder, tooth gel, chewing gum etc. other
Oral-cavity article is equally applicable.Without departing from the inventive concept of the premise, several modifications and improvements can also be made, these
Protection scope of the present invention should be considered as, these effects and practical applicability for implementing all without the influence present invention.
Claims (10)
1. a kind of oral-cavity article containing sodium azulenesulfonate, it is characterised in that its raw material is mainly by sodium azulenesulfonate, dipotassium glycyrrhizinate and nitre
Sour potassium composition, and the mass fraction of its raw material is respectively：0.001~3 part of sodium azulenesulfonate, 0.01~8 part of dipotassium glycyrrhizinate, nitric acid
0.01~10 part of potassium.
2. the oral-cavity article according to claim 1 containing sodium azulenesulfonate, it is characterised in that：Its product is toothpaste.
3. the oral-cavity article according to claim 1 containing sodium azulenesulfonate, it is characterised in that：Its product is mouthwash.
4. the oral-cavity article according to claim 1 containing sodium azulenesulfonate, it is characterised in that：Its product is tooth powder.
5. the oral-cavity article according to claim 2 containing sodium azulenesulfonate, it is characterised in that：The primary raw material quality of its toothpaste
Number is：0.001 part of sodium azulenesulfonate, 0.01 part of dipotassium glycyrrhizinate, 0.01 part of potassium nitrate；
Or 0.03 part of sodium azulenesulfonate, 0.1 part of dipotassium glycyrrhizinate, 0.3 part of potassium nitrate；
Or 0.03 part of sodium azulenesulfonate, 0.5 part of dipotassium glycyrrhizinate, 3 parts of potassium nitrate；
Or 0.1 part of sodium azulenesulfonate, 0.5 part of dipotassium glycyrrhizinate, 3 parts of potassium nitrate；
Or 0.1 part of sodium azulenesulfonate, 0.5 part of dipotassium glycyrrhizinate, 0.5 part of potassium nitrate.
6. the oral-cavity article according to claim 3 containing sodium azulenesulfonate, it is characterised in that：The primary raw material matter of its mouthwash
Measuring number is：0.01 part of sodium azulenesulfonate, 0.1 part of dipotassium glycyrrhizinate, 0.3 part of potassium nitrate；
Or 0.01 part of sodium azulenesulfonate, 0.3 part of dipotassium glycyrrhizinate, 1 part of potassium nitrate；
Or 0.08 part of sodium azulenesulfonate, 0.3 part of dipotassium glycyrrhizinate, 1 part of potassium nitrate；
Or 0.08 part of sodium azulenesulfonate, 0.3 part of dipotassium glycyrrhizinate, 0.5 part of potassium nitrate.
7. the oral-cavity article according to claim 4 containing sodium azulenesulfonate, it is characterised in that：The matter of the primary raw material of its tooth powder
Measuring number is：0.03 part of sodium azulenesulfonate, 0.1 part of dipotassium glycyrrhizinate, 0.3 part of potassium nitrate；
Or 0.03 part of sodium azulenesulfonate, 0.3 part of dipotassium glycyrrhizinate, 1 part of potassium nitrate；
Or 0.1 part of sodium azulenesulfonate, 0.3 part of dipotassium glycyrrhizinate, 1 part of potassium nitrate；
Or 0.1 part of sodium azulenesulfonate, 0.3 part of dipotassium glycyrrhizinate, 0.5 part of potassium nitrate.
8. the oral-cavity article containing sodium azulenesulfonate according to claim 5 ~ 7 any one, it is characterised in that：Described Azulene sulphur
The purity of sour sodium is more than 98%.
9. the oral-cavity article according to claim 8 containing sodium azulenesulfonate, it is characterised in that：Its product also includes tooth and coagulated
Glue or chewing gum.
10. the preparation method of toothpaste in the oral-cavity article according to claim 2 containing sodium azulenesulfonate, it is characterised in that：Its
Operating procedure includes：
The first step, add NMF glycerine, add adhesive, quickly stir homogeneous, sequentially add sweetener, saccharin sodium,
Sodium azulenesulfonate, dipotassium glycyrrhizinate, potassium nitrate, surfactant, preservative, and uniform stirring；
Second step, addition rubbing agent is vacuumized, stir homogeneous；
3rd step, essence is added, stir homogeneous, degassing, toothpaste completes.
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| CN201710155356.6A CN107411995A (en) | 2017-03-15 | 2017-03-15 | A kind of oral-cavity article containing sodium azulenesulfonate and preparation method thereof |
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| CN201710155356.6A CN107411995A (en) | 2017-03-15 | 2017-03-15 | A kind of oral-cavity article containing sodium azulenesulfonate and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107802507A (en) * | 2017-11-14 | 2018-03-16 | 名臣健康用品股份有限公司 | A kind of application and oral care product for dropping thorn composition in oral care product |
| CN112641684A (en) * | 2019-10-12 | 2021-04-13 | 福建爱洁丽日化有限公司 | Toothpaste for dental ulcer |
| CN114099524A (en) * | 2021-11-30 | 2022-03-01 | 上海格芒商贸有限责任公司 | Oral spray with effect of relieving piquancy |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106265423A (en) * | 2016-08-23 | 2017-01-04 | 广州立白企业集团有限公司 | Having relieves inflammation or internal heat disappear pain effect oral care composition |
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2017
- 2017-03-15 CN CN201710155356.6A patent/CN107411995A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106265423A (en) * | 2016-08-23 | 2017-01-04 | 广州立白企业集团有限公司 | Having relieves inflammation or internal heat disappear pain effect oral care composition |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107802507A (en) * | 2017-11-14 | 2018-03-16 | 名臣健康用品股份有限公司 | A kind of application and oral care product for dropping thorn composition in oral care product |
| CN107802507B (en) * | 2017-11-14 | 2020-07-28 | 名臣健康用品股份有限公司 | Application of thorn-reducing composition in preparation of oral care product and oral care product |
| CN112641684A (en) * | 2019-10-12 | 2021-04-13 | 福建爱洁丽日化有限公司 | Toothpaste for dental ulcer |
| CN114099524A (en) * | 2021-11-30 | 2022-03-01 | 上海格芒商贸有限责任公司 | Oral spray with effect of relieving piquancy |
| CN114099524B (en) * | 2021-11-30 | 2023-06-23 | 上海芒歌科技有限公司 | Oral spray with peppery relieving effect |
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Application publication date: 20171201 |
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