CN107281095A - A kind of gynaecology conserves gel with antibacterial - Google Patents
A kind of gynaecology conserves gel with antibacterial Download PDFInfo
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- CN107281095A CN107281095A CN201710499041.3A CN201710499041A CN107281095A CN 107281095 A CN107281095 A CN 107281095A CN 201710499041 A CN201710499041 A CN 201710499041A CN 107281095 A CN107281095 A CN 107281095A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/38—Silver; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
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- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Pharmacology & Pharmacy (AREA)
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- General Health & Medical Sciences (AREA)
- Inorganic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention discloses a kind of gynaecology and conserves gel with antibacterial, and preparation method is as follows：In parts by weight, 1~2 part of carbomer is taken to add in 80~120 parts of deionized water, stand 12~24h, 8~10 parts of glycerine is added, is stirred, 9~11 parts of sodium hydroxides or triethanolamine solution is added, stir, 40~100 parts of nanometer silver-platinum alloy colloidal sols are added, 9~11 parts of sodium hydroxides or triethanolamine solution are added after stirring, is stirred；Nanometer silver-platinum alloy colloidal sol preparation method be：20~60 parts of amidins are added in 1~4 part of silver nitrate and 1~4 part of chloroplatinic acid, 40~60 DEG C is heated to, stirs, 1.5~2.0 parts of D/Ws are added, keeping temperature stirs 1~3h, and natural cooling is produced.Inventive gel and human body skin bio-compatibility are more preferable, active stronger, effect purposes diversification of antibacterial bacteriostatic.
Description
Technical field
The invention belongs to anti-biotic material and metal nano material technical field, and in particular to one kind has antibacterial and maintenance work(
Gynaecology's gel of energy (anti-aging and anti-canceration).
Background technology
Gynecological disease (such as uterine neck and colpitis) is that the current incidence of disease is higher and directly affect women daily life quality
And be also the key problem for concerning women's health the problem of quality.Prevention, treatment and the care product master of current gynaecological imflammation
Have following several：(1) chemical antimicrobial DP finish gel or liquid, are directly discharged by entering medicine device or capsule, reach antibacterial
The effect of anti-inflammatory, such as：The composite chemical disinfectant (such as Ai Er boards skin mucosa disinfecting agent) of benzene oronain and Octoxinol composition is pricked,
With the chemical gel (such as rod maiden bacteriostatic gel) that poly hexamethylene biguanide is main active；(2) Chinese medicine class or natural
Antibacterial product, is discharged by entering medicine device or capsule in women private portion, so as to play the effect of sterilization and anti-inflammatory；Such as patent
CN201310111519.2, mainly with extracts such as kuh-seng, safflower, pseudo-ginseng, rhizoma arisaematis, the coptis, rheum officinales, is equipped with preservative trichlorine
Raw and carbomer is prepared into antibacterial gel, with biocidal efficacies, can penetrate into mucous membrane fold, foreign sense is nonirritant, can improve
The compliance of patient, and cleaning easy cleaning；Chitosan, tea tree ethereal oil, borneol, canopy are used if patent CN201310285895.3
Sand, carbomer, second alcohol and water etc. are as treatment Gynecological cervical and the antibacterial gel of vaginal disease, and antibacterial core is chitosan；Class
Like also patent CN201410108988.3, it is main active using chitosan iodine, bioactivity glass, with carbomer
It is adhesive with sodium alginate, the poly- glycosaminoglycan polypeptide chelated iodine with antibacterial repair function is constituted by setting agent of gelatin and is answered
Bioactivity glass gel is closed, wherein, Antibacterial Constituents are chitosan-modified iodine, and inventor thinks that it can provide free-iodine
Simple substance, is a kind of having available for treatment gynaecological imflammation so as to can also promote the healing at wound tissue position simultaneously in sterilization
The plasticity gel of antibacterial repairing activity；(3) ionic silver or antibacterial liquid or gel or suppository that Nano Silver is core, directly lead to
Cross into medicine device and enter women private portion；High-efficiency activated silver ion solution, card ripple are utilized as patent CN201510839986.6 is proposed
Nurse, eats sodium hydroxide, glycerine, menthol, ethyl hydroxy benzoate, and the bacteriostatic gel of ethanol and purified water treats bacterial woman
Section's disease；Patent CN200410062295.1 proposes to utilize bactericide containing silver H4Ag2O6Prepare preventing and treating women's genital tract infection and
Application in superficial skin fungus infection medicine；The synthesis of general Nano Silver is main to utilize extensive chemical reducing agent and good polymerization
Thing molecule as nano-particle stabilizing material, wherein, reducing agent is generally conventional strong reductant (such as hydrazine hydrate, NaBH4, and
Dimethylformamide (DMF) etc.), typically there is higher toxicity, bio-compatibility is poor, stabilizer is generally that chemical polymerization thing is high
Molecular material, such as PVP, PVA etc., stability of material is poor, and chemical polymerization thing modification Nano Silver may bring side effect.
To sum up, the primary efficacy of above-mentioned existing product is antibacterial bacteriostatic, comparatively, except Nano Silver has certain wound
Outside repair, other functional activities are very weak or substantially without active component, and function is generally more single, and with human body skin
Bio-compatibility is poor, also in the presence of different degrees of toxic side effect.
The content of the invention
For the problems of the prior art, the present invention is intended to provide a kind of and human body skin bio-compatibility is more preferable, antibacterial
Bacteriostatic activity is stronger, the gynaecology of effect purposes diversification conserves gel with antibacterial.
To realize above technical purpose, the technical scheme is that：
A kind of gynaecology conserves gel with antibacterial, it is characterised in that the preparation method of the gel is as follows：In parts by weight, take
1~2 part of carbomer is added in 80~120 parts of deionized water, stands 12~24h, is added 8~10 parts of glycerine, is stirred, then is added
Enter 9~11 parts of 0.05~0.08mol/L sodium hydroxides or triethanolamine solution, stir, then add 40~100 parts of nanometers
9~11 parts of 0.05~0.08mol/L sodium hydroxides or triethanolamine solution are added after silver-platinum alloy colloidal sol, stirring, stirring is equal
It is even；Wherein, the preparation method of the nanometer silver-platinum alloy colloidal sol is as follows：In 1~4 part of 0.10~0.15mol/L nitric acid
The starch water that 20~60 parts of concentration are 0.10~0.15wt% is added in silver and 1~4 part of 0.05~0.25mmol/L chloroplatinic acid
Solution, is heated to 40~60 DEG C, and stir mixing, and the glucose for adding 1.5~2.0 parts of 0.10~0.15mol/L is water-soluble
Liquid, 40~60 DEG C of keeping temperature stirs 1~3h, and natural cooling is produced.
Preferably, in parts by weight, when the nanometer silver-platinum alloy colloidal sol takes 40~60 parts, the silver nitrate concentration takes
0.1mol/L, the chloroplatinic acid concentration takes 0.25mmol/L, and it is maintenance type that made gynaecology conserves gel with antibacterial, and its effect is with pre-
Based on anti-and maintenance.
Preferably, in parts by weight, when the nanometer silver-platinum alloy colloidal sol takes 70~100 parts, the silver nitrate concentration
Take 0.1mol/L, the chloroplatinic acid concentration takes 0.1mmol/L, and it is antibacterial type that made gynaecology conserves gel with antibacterial, its effect with
Based on antibacterial and bactericidal antiphlogistic.
Preferably, in parts by weight, when the nanometer silver-platinum alloy colloidal sol takes 70~100 parts, the silver nitrate concentration
Take 0.1mol/L, the chloroplatinic acid concentration takes 0.05mmol/L, and it is therapeutic type that made gynaecology conserves gel with antibacterial, its effect with
Based on bactericidal antiphlogistic and reparation damage.
Preferably, the granular size of the nanometer silver-platinum alloy colloidal sol is 5~10 nanometers.
Preferably, the amidin concentration takes 0.10wt%.
Preferably, the D/W concentration takes 0.10mol/L.
Preferably, the sodium hydroxide or triethanolamine solution concentration take 0.05mol/L.
Completed preferably, the preparation of the nanometer silver-platinum alloy colloidal sol is whole under argon gas or the nitrogen protection of closing,
To prevent oxidation of the oxygen in air to Nano Silver.
From the above, it can be seen that the present invention possesses advantages below：
Gynaecology of the present invention is originated with gel using silver nitrate and chloroplatinic acid as silver and platinum, with All Pure Nature biological source Portugal
Grape sugar and starch is respectively as reducing agent and stabilizer, keep under strict control each raw material proportioning and technological parameter, and by adjusting silver-colored platinum
Content proportioning prepares the Nano Silver platinum alloy particles colloidal sol (three types) with extremely strong bacteriostasis antibiosis activity, further system
It is standby to obtain the Nano Silver platinum alloy particles gel with different leading effects, has a broad antifungal spectrum, product efficacy purposes diversification.Its
In, Nano Silver carries a large amount of negative electrical charges due to surface, directly can carry out electric charge transfer with the bacterium of contact or virus and reach kill
Bacterium and the purpose of virus, sulfenyl (- SH) that can be directly with bacterium or virus form chemical bond, bacterium or virus is lost activity
And it is dead, silver ion can be directly discharged, is acted on virus or bacteria cell wall, so as to kill bacterium or virus；Nano platinum can
Acted in the skin surface of effect and the sulfenyl (- SH) of cell and amino (- NH2), platinum chelation structure is formed, with very strong
The activity that anticancer becomes or cellular elements is mutated, can reach the purpose of anti-cancer, in addition, platinum chelation structure is in cellular elements system
The breath cycle or rate of metabolism of cellular elements are reduced, the purpose of anti-aging is can reach, finally, due to nano platinum pole
Strong activity and penetration capacity, the anti-oxidant anti-cancer mutation overcoat formed in subcutaneous 3~5 mm depth.Nano Silver of the present invention
Platinum alloy particles are overall as an activity, can cooperate with and efficiently play antibacterial and bacteriostasis, at the same have reparation concurrently, it is anti-oxidant, anti-
Aging and anti-cancer multi-efficiency, reach maintenance and treatment dual purpose.The present invention is reduced and repaiied with biological source natural materials
Decorations, compared with conventional chemical is polymer-modified, except possessing in addition to excellent stability, bio-compatibility is high, can be preferably
Combined and played a role with human tissue cell, and safety has no side effect.
Brief description of the drawings
Fig. 1 is the principle of oxidation and reduction schematic diagram of embodiment 1.
Fig. 2 is the projection electron microscope of 2 made nanometers of silver-platinum alloy sol particles of embodiment.
Embodiment
Below in conjunction with the accompanying drawings, several specific embodiments of the present invention are described in detail, but the claim to the present invention is not done
It is any to limit.
The preparation of embodiment 1A types nanometer silver-platinum alloy colloidal sol
In parts by weight, 1 part of 0.1mol/L silver nitrate and 1 part of 0.25mmol/L chloroplatinic acid are taken, 60 parts of concentration are added
0.10wt% amidin, is heated to 50 DEG C, stirring makes uniform mixing for 5 minutes, adds 1.5 parts of 0.10mol/L Portugal
Grape sugar aqueous solution, keeping temperature is 50 DEG C, is stirred 2 hours, natural cooling, obtains A types nanometer silver-platinum alloy colloidal sol, granular size
For 5~10 nanometers.
The preparation of embodiment 2B types nanometer silver-platinum alloy colloidal sol
In parts by weight, 1 part of 0.1mol/L silver nitrate and 1 part of 0.1mmol/L chloroplatinic acid are taken, 60 parts of concentration are added
0.10wt% amidin, is heated to 40 DEG C, stirring makes uniform mixing for 8 minutes, adds 1.5 parts of 0.1mol/L grape
Sugar aqueous solution, keeping temperature is 40 DEG C, is stirred 1 hour, natural cooling, obtains Type B nanometer silver-platinum alloy colloidal sol, and granular size is
5~10 nanometers.
The preparation of embodiment 3C types nanometer silver-platinum alloy colloidal sol
In parts by weight, 1 part of 0.1mol/L silver nitrate and 1 part of 0.05mmol/L chloroplatinic acid are taken, 60 parts of concentration are added
0.10wt% amidin, is heated to 60 DEG C, stirring makes uniform mixing for 10 minutes, adds 1.5 parts of 0.1mol/L Portugal
Grape sugar aqueous solution, keeping temperature is 60 DEG C, is stirred 3 hours, natural cooling, obtains c-type nanometer silver-platinum alloy colloidal sol, granular size
For 5~10 nanometers.
It is as shown in Figure 1 silver nitrate and chloroplatinic acid reduction reaction principle schematic in 1~embodiment of embodiment 3, with nitric acid
Silver is silver source, is originated using chloroplatinic acid as platinum, using biological source natural grape sugar and starch as reducing agent and stably
Agent, dramatically reduces risk of toxicity, compared with conventional chemical is polymer-modified, the nanometer silver-platinum alloy of bio-modification,
Except possessing in addition to excellent stability, bio-compatibility is high, can preferably be combined and played a role with human tissue cell,
And safety has no side effect.
The preparation of the maintenance type gel of embodiment 4
In parts by weight, take 1 part of carbomer to be added in 120 parts of deionized waters, static 24 hours, add 10 parts of glycerine,
Stir, then add 9 parts of 0.05mol/L sodium hydroxide solutions, stir, add 40~60 parts of A type Nano Silvers
9 parts of 0.05mol/L sodium hydroxide solution is added after platinum alloy colloidal sol, 5~10min of stirring, stirs and produces.
The preparation of the antibacterial type gel of embodiment 5
In parts by weight, take 1 part of carbomer to be added in 120 parts of deionized waters, static 24 hours, add 10 parts of glycerine,
Stir, then add 10 parts of 0.05mol/L triethanolamine solution, stir, the Type B for adding 70~100 parts is received
Rice silver-platinum alloy colloidal sol, stirring adds 10 parts of 0.05mol/L triethanolamine solution, stirs and produce after 5~10 minutes.
The preparation of the therapeutic type gel of embodiment 6
In parts by weight, take 1 part of carbomer to be added in 120 parts of deionized waters, static 24 hours, add 10 parts of glycerine,
Stir, then add 9 parts of 0.05mol/L triethanolamine solution, stir, add 70~100 parts of c-type nanometer
Silver-platinum alloy colloidal sol, stirring adds 9 parts of 0.05mol/L triethanolamine solution after 5~10 minutes, stir and produce.
Application method：Every gel, which enters medicine device, can fill gel capacity for 3~5ml, be positioned over the release of women private portion.
Anti-microbial property is detected
According to national standard GB15979-2002 disposable sanitary articles standards, the made Nano Silver platinum of 1~embodiment of Example 3
The nanometer silver-platinum alloy solution that alloy colloidal sol is diluted to 5ppm respectively tests minimal inhibitory concentration (Mic) respectively, measures minimum suppression
Bacteria concentration (Mic) is 2~3ppm, hence it is evident that better than the 5ppm of conventional report.
The made gel of 4~embodiment of Example 6 tests bacteriostasis rate respectively, and detection data are referring to table 1：
The gel bacteriostasis property of 1 4~embodiment of embodiment of table 6 is tested
From upper table data, Escherichia coli 8099, staphylococcus aureus ATCC6538 and Candida albicans
ATCC10231 bacteriostasis rate has reached 99.99%；In terms of properties of product, the silver-colored gynecological antibacterial of the commercially available clean efficient monomers of Bang Er coagulates
Glue, when its Nano Silver consumption is up to 350ppm bacteriostasis rate be ＞ 90%, and inventive gel usage amount be 250ppm when, bacteriostasis rate
It can reach ＞ 99.99%, it was demonstrated that gynaecology of the present invention conserves gel with antibacterial has extremely strong antibacterial bacteriostatic activity.
It is understood that above with respect to the specific descriptions of the present invention, being merely to illustrate the present invention and being not limited to this
Technical scheme described by inventive embodiments.It will be understood by those within the art that, still can be to present invention progress
Modification or equivalent substitution, to reach identical technique effect；As long as meet use needs, all protection scope of the present invention it
It is interior.
Claims (9)
1. a kind of gynaecology conserves gel with antibacterial, it is characterised in that the preparation method of the gel is as follows：In parts by weight, card taking
1~2 part of ripple nurse is added in 80~120 parts of deionized water, stands 12~24h, is added 8~10 parts of glycerine, is stirred, add
9~11 parts of 0.05~0.08mol/L sodium hydroxides or triethanolamine solution, stir, and then add 40~100 parts of Nano Silvers
9~11 parts of 0.05~0.08mol/L sodium hydroxides or triethanolamine solution are added after platinum alloy colloidal sol, stirring, is stirred
；Wherein, the preparation method of the nanometer silver-platinum alloy colloidal sol is as follows：In 1~4 part of 0.10~0.15mol/L silver nitrate
It is water-soluble for 0.10~0.15wt% starch with 20~60 parts of concentration are added in 1~4 part of 0.05~0.25mmol/L chloroplatinic acid
Liquid, is heated to 40~60 DEG C, and stir mixing, adds 1.5~2.0 parts of 0.10~0.15mol/L D/W,
40~60 DEG C of keeping temperature, stirs 1~3h, and natural cooling is produced.
2. gynaecology according to claim 1 conserves gel with antibacterial, it is characterised in that：In parts by weight, when the nanometer
Silver-platinum alloy colloidal sol takes 40~60 parts, and the silver nitrate concentration takes 0.10mol/L, and the chloroplatinic acid concentration takes 0.25mmol/L,
It is maintenance type that made gynaecology conserves gel with antibacterial.
3. gynaecology according to claim 1 conserves gel with antibacterial, it is characterised in that：In parts by weight, when the nanometer
Silver-platinum alloy colloidal sol takes 70~100 parts, and the silver nitrate concentration takes 0.10mol/L, and the chloroplatinic acid concentration takes 0.1mmol/L,
It is antibacterial type that made gynaecology conserves gel with antibacterial.
4. gynaecology according to claim 1 conserves gel with antibacterial, it is characterised in that：In parts by weight, when the nanometer
Silver-platinum alloy colloidal sol takes 70~100 parts, and the silver nitrate concentration takes 0.10mol/L, and the chloroplatinic acid concentration takes 0.05mmol/L,
It is therapeutic type that made gynaecology conserves gel with antibacterial.
5. gynaecology according to claim 1 conserves gel with antibacterial, it is characterised in that：The nanometer silver-platinum alloy colloidal sol
Granular size is 5~10 nanometers.
6. gynaecology according to claim 1 conserves gel with antibacterial, it is characterised in that：The amidin concentration takes
0.10wt%.
7. gynaecology according to claim 1 conserves gel with antibacterial, it is characterised in that：The D/W concentration takes
0.10mol/L。
8. gynaecology according to claim 1 conserves gel with antibacterial, it is characterised in that：The sodium hydroxide or triethanolamine
Solution concentration takes 0.05mol/L.
9. gynaecology according to claim 1 conserves gel with antibacterial, it is characterised in that：The nanometer silver-platinum alloy colloidal sol
Prepare the whole completion under argon gas or the nitrogen protection of closing.
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| CN201710499041.3A CN107281095A (en) | 2017-06-26 | 2017-06-26 | A kind of gynaecology conserves gel with antibacterial |
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| CN201710499041.3A CN107281095A (en) | 2017-06-26 | 2017-06-26 | A kind of gynaecology conserves gel with antibacterial |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112545978A (en) * | 2020-12-15 | 2021-03-26 | 上海利康消毒高科技有限公司 | Oral care gel with effect of resisting helicobacter pylori in sustained manner and preparation method thereof |
| CN113244268A (en) * | 2021-04-12 | 2021-08-13 | 青岛海洋生物医药研究院股份有限公司 | Bacteriostatic gel containing sulfated polysaccharide-nano silver complex and application thereof |
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|---|---|---|---|---|
| CN1672689A (en) * | 2004-03-26 | 2005-09-28 | 深圳市爱杰特医药科技有限公司 | Nano silver antiseptic gel for treating women's genital tract infection and its prepn and application |
| CN1903171A (en) * | 2006-08-04 | 2007-01-31 | 武汉正午阳光医药生物科技有限公司 | Nanometer silver type external use antibiotic gel for female external use and its prepn. method |
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2017
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1672689A (en) * | 2004-03-26 | 2005-09-28 | 深圳市爱杰特医药科技有限公司 | Nano silver antiseptic gel for treating women's genital tract infection and its prepn and application |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112545978A (en) * | 2020-12-15 | 2021-03-26 | 上海利康消毒高科技有限公司 | Oral care gel with effect of resisting helicobacter pylori in sustained manner and preparation method thereof |
| CN113244268A (en) * | 2021-04-12 | 2021-08-13 | 青岛海洋生物医药研究院股份有限公司 | Bacteriostatic gel containing sulfated polysaccharide-nano silver complex and application thereof |
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Application publication date: 20171024 |