CN107050233A - A kind of Chinese medicine paste formulation and preparation method for treating diabetes skin damaged - Google Patents
A kind of Chinese medicine paste formulation and preparation method for treating diabetes skin damaged Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine paste formulation and preparation method for treating diabetes skin damaged, including Chinese medicine paste formulation, Chinese medicine ointment preparation, powder of Chinese traditional medicine preparation method, Traditional Chinese medicine tincture preparation method, characterized in that, the active ingredient and its mass fraction of the Chinese medicine paste formulation of the treatment diabetes skin damaged are：15 parts of Moschus (MOSCHUS BEREZOVSKII FLEROV), 10 30 parts of safflower (CARTHAMUS TINCTORIUS L), 5 25 parts of pine bark (PINUS MASSONIANA LAMB), 10 20 parts of elm bark (ULMUS PUMILA L.), 5 20 parts of dragon's blood (DAEMONOROPS DRACO BL.), 5 15 parts of cony fur (CONY FUR), 10 25 parts of the coptis (COPTIS CHINENSIS FRANCH.).The invention also discloses a kind of three kinds of preparation methods of the Chinese medicine paste formulation for treating diabetes skin damaged：Chinese medicine ointment preparation, powder of Chinese traditional medicine preparation method, Traditional Chinese medicine tincture preparation method.
Description
Technical field
The present invention relates to a kind of technical field of traditional Chinese medicines, more particularly to a kind of diabetes skin damaged for the treatment of
Chinese medicine paste formulation and preparation method.
Background technology
The Chinese medicine paste formulation of the treatment diabetes skin damaged of prior art is innumerable, exists mostly such as
Lower shortcoming：Analgesic effect is poor, and patient suffering is larger during dressing, and medicine antibacterial ability, the surface of a wound is cured
Close slow, the course of disease is longer, typically all need to coordinate skin grafting and amputation to can be only achieved healing, after healing
Quality of life after most patients turn into disabled person and influenceed, so as to aggravate country, family and sufferer
Burden.Chinese medicine paste formulation of the present invention using Moschus, safflower, pine bark, elm bark, dragon's blood,
Cony fur, coptis composition, reach healing with anti-infective, promotion wound tissue cytothesis and subtract
The characteristics of few scar is formed.Follow the principle of traditional Chinese medicine interpromoting relation in five elements, mutual reinforcement between, mutual restraint between two drugs, restriction or checking relation in five elements, Chinese medicine
Bulk formulation compatibility is proper, and then shows its distinctive curative effect, hence it is evident that improve cure rate, shortens and treats
Journey, pain are small and have no adverse reaction, can putrefaction-removing granulation-promoting, anti-inflammation, improve surface of a wound blood circulation,
The skin tissue cell of the surface of a wound is promoted to breed, divide, regenerate, so that accelerating wound healing.Overcome
The deficiencies in the prior art.
The content of the invention
1st, it is an object of the invention to provide a kind of Chinese medicine paste formulation for treating diabetes skin damaged, close
The Chinese medicine paste formulation analgesic effect for solving to reason the treatment diabetes skin damaged of prior art is poor, changes
Patient suffering is big during medicine, medicine antibacterial ability, and wound healing is slow, and the course of disease is longer, typically all needs
Coordinate the problem of skin grafting and amputation can be only achieved healing.
The present invention is adopted the following technical scheme that：
A kind of Chinese medicine paste formulation and preparation method for treating diabetes skin damaged, including Chinese medicine paste formulation,
Chinese medicine ointment preparation, powder of Chinese traditional medicine preparation method, Traditional Chinese medicine tincture preparation method, it is characterised in that institute
State treatment diabetes skin damaged Chinese medicine paste formulation active ingredient and its mass fraction be：Moschus
1-5 parts of (MOSCHUS BEREZOVSKII FLEROV), safflower (CARTHAMUS TINCTORIUS
L) 10-30 parts, pine bark (PINUS MASSONIANA LAMB) 5-25 parts, elm bark (ULMUS
PUMILA L.) 10-20 parts, dragon's blood (DAEMONOROPS DRACO BL.) 5-20 parts, rabbit
Hair 5-15 parts of (CONY FUR), 10-25 parts of the coptis (COPTIS CHINENSIS FRANCH.).
The most preferably active ingredient and its mass fraction of the Chinese medicine paste formulation of the treatment diabetes skin damaged
For：3 parts of Moschus (MOSCHUS BEREZOVSKII FLEROV), safflower (CARTHAMUS TINCTORIUS
L) 20 parts, 16 parts of pine bark (PINUS MASSONIANA LAMB), elm bark (ULMUS PUMILA
L.) 15 parts, 16 parts of dragon's blood (DAEMONOROPS DRACO BL.), cony fur (CONY FUR)
15 parts, 15 parts of the coptis (COPTIS CHINENSIS FRANCH.).
Further, the Chinese medicine paste formulation of the treatment diabetes skin damaged is external application Chinese medicine paste formulation.
The pharmacological action of Chinese medicine material：
Moschus (MOSCHUS BEREZOVSKII FLEROV)：Moschus is pungent, warm-natured；The thoughts of returning home,
Liver, the spleen channel；It is fragrant it is strong alter scattered, can rise to drop, with inducing resuscitation of having one's ideas straightened out, blood circulation promoting and dispersing pathogen accumulation, alleviating pain and detumescence,
Effect of lower tire is expedited the emergence of, pyreticosis coma, apoplexy coma due to blocking of the respiratory system, bstruction of the circulation of vital energy is fainted cruelly, middle evil is gone into a coma, blood is cured mainly
Stasis of blood Amenorrhea, dysmenorrhoea, accumulation, trusted subordinate sudden and violent pain, arthralgia pain due to rheumatism, traumatic injury, ulcer malignant sore, larynx
Numbness, aphtha.
Modern study shows：Immunologic function, musk water-soluble albumen is to humoral immunity and cellular immunity
There is humidification.Germicidal efficacy is immunized mouse to intraperitoneal injection sheep red blood cell (SRBC) to Moschus and produces antibody
Gavage M unrestraints are acted on.Seemingly there is humidification.Moschus is acted on without immune induction, but continuous in antigen
In the presence of sheep red blood cell, Moschus can significantly increase experiment mice spleen.
Antitumor action, natural musk or muskone to mouse ehrlich ascites cancer, S37 and S180's
Cellular respiration inhibiting rate, is above normal mouse inhibiting rate.The country uses different way of administration, and
From different sensitive knurl strains, naturally with musk ambrette ketone to W256 ascites tumors, W256 solid tumors, S180
The knurl such as sarcoma and L615 mouse leukemias spectrum is without obvious inhibitory action, from the experimental results,
Moschus has destruction in vitro animal cancer cell, and the cellular respiration to animal tumor tissue has substantially
Inhibitory action, and anti-tumor experiment is not it is observed that curative effect in animal body.
Other effects, 1: 400 dilution of 2% musk tincture, can suppress hog cholera vibrios in vitro,
Escherichia coli and the growth of S. aureus L-forms.Moschus water extract can significantly improve adrenal gland vitamin C and blood
The content of middle cortisone, cAMP, PGE, PGF2a, and have suppression platelet aggregation.In addition,
Also anti-snake venom and antihistamine etc. are acted on.
Safflower (CARTHAMUS TINCTORIUS L)：Nature and flavor：It is pungent, temperature.Enter the heart, Liver Channel.
Major function：Invigorate blood circulation, stasis eliminatings analgesic, hemostasis is had a pain, carbuncle swells, injury from falling down.《Detailed outline》：
Promoting blood circulation, moisturizes, and relieves pain, and dissipates swollen, stimulates the menstrual flow.《Book on Chinese herbal medicine is new again》：Inducing diuresis for removing edema.
Pine bark (PINUS MASSONIANA LAMB)：《Compendium of Materia Medica》Record：It is bitter, puckery,
Temperature.Return lung；Large intestine channel.Convergence, myogenic.Burn and scald, infantile eczema are controlled in external application.《In the whole nation
Glossary of Herbs and Drugs》Masson pine bark is used for dispelling wind and eliminating dampness；Promoting blood circulation and hemostasis, expelling pus and promoting granulation.Cure mainly treating rheumatic ostealgia；
Traumatic injury；Incised wound；Discharging fresh blood stool；Protracted dysentery；Eczema；Burn and scald, ulcer does not close up long.
《Class official seal side forever》：Age-old pine trees skin, forges sustainability, it is lined up it, most relieve pain.
Elm bark (ULMUS PUMILA L.)：It is sweet, flat.It is nontoxic.Li Shui, treating stranguria, detumescence.
Dragon's blood (DAEMONOROPS DRACO BL.)：Nature and flavor are sweet, salty, put down.The thoughts of returning home, Liver Channel.
For traumatic injury, trusted subordinate's stasis caused pain, traumatism and bleeding, sore is not held back.
Cony fur (CONY FUR)：《Tang materia medica》Cure mainly post-moxibustion sore not hold back long, scald.《Book on Chinese herbal medicine
Pick up any lost article from the road》：" hair ashing, main post-moxibustion sore is not recovered." blood circulation and stasis-eliminating medicine.
The coptis (COPTIS CHINENSIS FRANCH.)：Bitter, it is cold in nature.The thoughts of returning home, spleen, stomach,
Liver, courage, large intestine channel.Heat-clearing and damp-drying drug, purging intense heat and detonicating.Dysphoria and insomnia is cured mainly, palpitation and uneasiness disappears
Yearningly, carbuncle swells treat sore；Control eczema, wet sore outside.
2 the present invention also aims to provide a kind of Chinese medicine paste formulation for treating diabetes skin damaged
Three kinds of preparation methods, the preparation method of the traditional Chinese medicinal ointment of (1) described treatment diabetes skin damaged, including
Add vaseline prothetic group and following steps：
Step 1: getting the raw materials ready：It is former that Chinese medicine is weighed by the Chinese medicine paste formulation of the treatment diabetes skin damaged
Material；
Step 2: standby prothetic group：By the Chinese medicine paste formulation Chinese medicine material of the treatment diabetes skin damaged
Gross mass part 1: 19 weighs vaseline prothetic group；
Step 3: crushing：The Chinese medicine material in addition to Moschus weighed in the step one is ground into
Smalls is mixed；
Step 4: once boiling：Chinese medicine material powder made from the step 3 is slowly added into heating
Vaseline in and be stirred continuously, make it uniform, just to see that oil smoke, to spend, 20-30 is boiled with slow fire again
Minute, residue is pulled out；
Step 5: secondary boil：Moschus is added, is stirred continuously and is allowed to dissolve, then boils 4-5 points
Clock；
Step 6: being cooled to traditional Chinese medicinal ointment.
(2) the powder of Chinese traditional medicine preparation method is to match somebody with somebody the traditional Chinese medicinal ointment by the treatment diabetes skin damaged
The Chinese medicine material that side is weighed is ground into smalls jointly, crosses 100 mesh sieves and takes, and sterilization sealing is prepared
The external application Chinese medicine of the Chinese medicine paste formulation of the treatment diabetes skin damaged dissipates.
(3) the Traditional Chinese medicine tincture preparation method is to match somebody with somebody the traditional Chinese medicinal ointment by the treatment diabetes skin damaged
The Chinese medicine material mixture that side is weighed is put into 75% alcohol and sealed, and immersion prepares described on the 20th
Treat the external application Chinese medicine tincture of the Chinese medicine paste formulation of diabetes skin damaged.
Further, the step 5 system in the Chinese medicine ointment preparation of the treatment diabetes skin damaged
Into product, the gauze disinfected or non-woven fabrics are impregnated with while hot can prepare the diabetes skin damaged surface of a wound
External application dressing.
The method have the benefit that：
(1) the invention discloses a kind of Chinese medicine paste formulation for treating diabetes skin damaged, reasonably solve
The Chinese medicine paste formulation analgesic effect of the treatment diabetes skin damaged for prior art of having determined is poor, suffers from during dressing
Person's pain is big, and medicine antibacterial ability, wound healing is slow, and the course of disease is longer, typically all needs to coordinate to plant
The problem of skin is performed the operation and amputation can be only achieved healing.Chinese medicine paste formulation of the present invention using Moschus, safflower,
Pine bark, elm bark, dragon's blood, cony fur, coptis composition, with anti-infective, promotion surface of a wound group
Cytothesis is knitted to reach healing and reduce the characteristics of scar is formed.Follow traditional Chinese medicine interpromoting relation in five elements, mutual reinforcement between,
Mutual restraint between two drugs, the principle of restriction or checking relation in five elements, Chinese medicine material preparation compatibility are proper, and then show its distinctive curative effect,
Cure rate is significantly improved, shortens the course for the treatment of, pain is small and has no adverse reaction, can putrefaction-removing granulation-promoting, antibacterial
Anti-inflammatory, improvement surface of a wound blood circulation, promote the skin tissue cell of the surface of a wound to breed, divide, regenerate,
So as to accelerating wound healing.Overcome the deficiencies in the prior art.
(2) the invention also discloses a kind of system of three kinds of Chinese medicine paste formulation for treating diabetes skin damaged
Preparation Method：Chinese medicine ointment preparation, powder of Chinese traditional medicine preparation method, Traditional Chinese medicine tincture preparation method.
Embodiment
By the following description to embodiment, it will more contribute to the public understanding present invention, but can not
Specific embodiment given by applicant should not be also considered as to the limit to technical solution of the present invention
System, any definition to part or technical characteristic be changed and/or overall structure made form and
Immaterial conversion is regarded as the protection domain that technical scheme is limited.
Experimental example
1st, clinical data：60 patient with diabetic feet of this experimental group, wherein, man 38, female 22
Example；It is age 60-91 Sui, average 69.5 years old；Diabetes are with cerebral infarction 35, cerebral hemorrhage 4
Example, caput femoris necrosis 5, coronary heart disease 6, other 10.Fasting blood sugar 9.1mmol/L~
24.3mmol/L.By diabetes diagnostic criteria [1]：0 grade：The cool fiber crops of trick are bitterly or insensitive
To forfeiture.1 grade：Skin blister, corn, callosity, frostbite, scald, but do not involve deep tissues.
2 grades：Skin fester is to deep muscle tissue, and invading deep tissue has slight cellulitis,
Multiple abscess and sinus but tendon ligament there is no breakage.3 grades：Destruction of bone it is downright bad and it is postoperative not
Sealing, tendon tissue destruction, slough increases, toes dry gangrene, but destruction of bone is still not
Substantially.4 grades：Destruction of bone is serious, osteomyelitis, Bones and joints destruction etc..5 grades：Foot big portion or complete
Foot infection or ischemic necrosis.
By table of random number, observation group's (invention formulation group) and control group, each 30 are randomly divided into
Example.Two groups of patient ages, sex, diabetes are classified (object is 2/3/4/5 grade) and face
Product is statistically analyzed, and there was no significant difference, with comparativity.
2nd, treatment method：It is real while systematic treating diabetes skin damaged protopathy and complication
Foot is suffered from the measure applied, prevent diabetes to be in progress, such as massage daily, and timed motion suffers from foot,
Raise trouble foot, promote its blood circulation etc..
Invention formulation group：2 grades：Surface of a wound slough is removed in sterilization, and ointment is evenly coated in wound
And surrounding, gauze wrapping, same day dressing 1 time.3rd, 4,5 grades：Sterile surgical removes gangrenous
The tendon and bone tissue of necrosis completely, then the surface of a wound apply ointment, gauze wrapping, daily dressing 1
It is secondary, 30 days observation curative effects.
Control group：2 grades are used the normal saline flushing surface of a wound, 0.5% iodophor disinfection periwound skin, it
160,000 U gentamicins are soaked with appropriately sized gauze layer 2-3 afterwards plus insulin 12U decoctions are spread on
The surface of a wound, aseptic dressing wrapping, daily dressing 1 time.3rd, 4,5 grades：With 0.02% furacillin solution
Clean the surface of a wound, it is other ibid, 30 days observation curative effect.
3rd, statistical result
After total course for the treatment of of 30 days terminates, two groups of therapeutic effects are relatively shown in Table 1. Chinese medicine materials invention system
Agent group effective percentage 100%, cure rate 76.67%, better than control group 33.33%.
Table 1：Two groups of therapeutic effects compare
Two groups of cure time comparison sheets 2. show that the Chinese medicine material invention preparation group course for the treatment of is significantly shorter than control
Group.Do not find that Chinese medicine material invention preparation group has any adverse reaction in therapeutic process.
Table 2：Two groups of cure times compare
Embodiment one
A kind of Chinese medicine paste formulation and preparation method for treating diabetes skin damaged as described in experimental example, bag
Include Chinese medicine paste formulation, Chinese medicine ointment preparation, powder of Chinese traditional medicine preparation method, Traditional Chinese medicine tincture preparation method.
It is described treatment diabetes skin damaged Chinese medicine paste formulation active ingredient and its mass fraction be：
1-5 parts of Moschus (MOSCHUS BEREZOVSKII FLEROV), safflower (CARTHAMUS TINCTORIUS
L) 10-30 parts, pine bark (PINUS MASSONIANA LAMB) 5-25 parts, elm bark (ULMUS
PUMILA L.) 10-20 parts, dragon's blood (DAEMONOROPS DRACO BL.) 5-20 parts, rabbit
Hair 5-15 parts of (CONY FUR), 10-25 parts of the coptis (COPTIS CHINENSIS FRANCH.).
Embodiment two
The most preferably active ingredient and its mass parts of the Chinese medicine paste formulation of the treatment diabetes skin damaged
Number is：3 parts of Moschus (MOSCHUS BEREZOVSKII FLEROV), safflower (CARTHAMUS
TINCTORIUS L) 20 parts, 16 parts of pine bark (PINUS MASSONIANA LAMB), elm
15 parts of skin (ULMUS PUMILA L.), 16 parts of dragon's blood (DAEMONOROPS DRACO BL.),
15 parts of cony fur (CONY FUR), 15 parts of the coptis (COPTIS CHINENSIS FRANCH.).
Embodiment three
The preparation method of the traditional Chinese medicinal ointment of the treatment diabetes skin damaged, including add vaseline prothetic group
And following steps：
Step 1: getting the raw materials ready：It is former that Chinese medicine is weighed by the Chinese medicine paste formulation of the treatment diabetes skin damaged
Material；
Step 2: standby prothetic group：By the Chinese medicine paste formulation Chinese medicine material of the treatment diabetes skin damaged
Gross mass part 1: 19 weighs vaseline prothetic group；
Step 3: crushing：The Chinese medicine material in addition to Moschus weighed in the step one is ground into
Smalls is mixed；
Step 4: once boiling：Chinese medicine material powder made from the step 3 is slowly added into heating
Vaseline in and be stirred continuously, make it uniform, just to see that oil smoke, to spend, 20-30 is boiled with slow fire again
Minute, residue is pulled out；
Step 5: secondary boil：Moschus is added, is stirred continuously and is allowed to dissolve, then boils 4-5 points
Clock；
Step 6: being cooled to traditional Chinese medicinal ointment.
Example IV
The powder of Chinese traditional medicine preparation method is to claim the Chinese medicine paste formulation by the treatment diabetes skin damaged
The Chinese medicine material taken is ground into smalls jointly, crosses 100 mesh sieves and takes, and sterilization sealing is prepared described
The external application Chinese medicine for treating the Chinese medicine paste formulation of diabetes skin damaged dissipates.
Embodiment five
The Traditional Chinese medicine tincture preparation method is to claim the Chinese medicine paste formulation by the treatment diabetes skin damaged
The Chinese medicine material mixture taken is put into 75% alcohol and sealed, and immersion prepares the treatment on 20th
The external application Chinese medicine tincture of the Chinese medicine paste formulation of diabetes skin damaged.
Certainly, the present invention can also have other various embodiments, without departing substantially from spirit of the invention and its
In the case of essence, those skilled in the art can make various corresponding according to the present invention
Change and deform, but these corresponding changes and deformation should all belong to appended claims of the invention
Protection domain.
Claims (6)
1. a kind of Chinese medicine paste formulation and preparation method for treating diabetes skin damaged, including traditional Chinese medicinal ointment are matched somebody with somebody
Side, Chinese medicine ointment preparation, powder of Chinese traditional medicine preparation method, Traditional Chinese medicine tincture preparation method, it is characterised in that
It is described treatment diabetes skin damaged Chinese medicine paste formulation active ingredient and its mass fraction be：Moschus
1-5 parts of (MOSCHUS BEREZOVSKII FLEROV), safflower (CARTHAMUS TINCTORIUS
L) 10-30 parts, pine bark (PINUS MASSONIANA LAMB) 5-25 parts, elm bark (ULMUS
PUMILA L.) 10-20 parts, dragon's blood (DAEMONOROPS DRACO BL.) 5-20 parts, rabbit
Hair 5-15 parts of (CONY FUR), 10-25 parts of the coptis (COPTIS CHINENSIS FRANCH.)；
The preparation method of the traditional Chinese medicinal ointment of the treatment diabetes skin damaged, including add vaseline prothetic group
And following steps：
Step 1: getting the raw materials ready：It is former that Chinese medicine is weighed by the Chinese medicine paste formulation of the treatment diabetes skin damaged
Material；
Step 2: standby prothetic group：By the Chinese medicine paste formulation Chinese medicine material of the treatment diabetes skin damaged
Gross mass part 1: 19 weighs vaseline prothetic group；
Step 3: crushing：The Chinese medicine material in addition to Moschus weighed in the step one is ground into
Smalls is mixed；
Step 4: once boiling：Chinese medicine material powder made from the step 3 is slowly added into heating
Vaseline in and be stirred continuously, make it uniform, just to see that oil smoke, to spend, 20-30 is boiled with slow fire again
Minute, residue is pulled out；
Step 5: secondary boil：Moschus is added, is stirred continuously and is allowed to dissolve, then boils 4-5 points
Clock；
Step 6: being cooled to traditional Chinese medicinal ointment.
2. a kind of Chinese medicine paste formulation for treating diabetes skin damaged and preparation according to claim 1
Method, it is characterised in that the Chinese medicine paste formulation of the treatment diabetes skin damaged it is most preferably effective
Composition and its mass fraction are：3 parts of Moschus (MOSCHUS BEREZOVSKII FLEROV), safflower
20 parts of (CARTHAMUS TINCTORIUS L), pine bark (PINUS MASSONIANA LAMB)
16 parts, 15 parts of elm bark (ULMUS PUMILA L.), dragon's blood (DAEMONOROPS DRACO BL.)
16 parts, 15 parts of cony fur (CONY FUR), the coptis (COPTIS CHINENSIS FRANCH.)
15 parts.
3. a kind of Chinese medicine paste formulation for treating diabetes skin damaged and preparation according to claim 1
Method, it is characterised in that the Chinese medicine paste formulation of the treatment diabetes skin damaged is Chinese medicine lotion for external use
Formula.
4. a kind of Chinese medicine paste formulation for treating diabetes skin damaged and preparation according to claim 1
Method, it is characterised in that the step in the Chinese medicine ointment preparation of the treatment diabetes skin damaged
Five products being made, the gauze disinfected or non-woven fabrics are impregnated with while hot can prepare diabetes skin damaged
The external application dressing of the surface of a wound.
5. a kind of Chinese medicine paste formulation for treating diabetes skin damaged and preparation according to claim 1
Method, it is characterised in that the powder of Chinese traditional medicine preparation method is will be by the treatment diabetes skin damaged
The Chinese medicine material that weighs of Chinese medicine paste formulation be ground into smalls jointly, cross 100 mesh sieves and take, sterilize close
Envelope, that is, the external application Chinese medicine for preparing the Chinese medicine paste formulation of the treatment diabetes skin damaged dissipates.
6. a kind of Chinese medicine paste formulation for treating diabetes skin damaged and preparation according to claim 1
Method, it is characterised in that the Traditional Chinese medicine tincture preparation method is will be by the treatment diabetes skin damaged
The Chinese medicine material mixture that weighs of Chinese medicine paste formulation be put into 75% alcohol and seal, soak 20
Prepare the external application Chinese medicine tincture of the Chinese medicine paste formulation of the treatment diabetes skin damaged.
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| CN201610080170.4A CN107050233A (en) | 2016-02-05 | 2016-02-05 | A kind of Chinese medicine paste formulation and preparation method for treating diabetes skin damaged |
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| CN201610080170.4A CN107050233A (en) | 2016-02-05 | 2016-02-05 | A kind of Chinese medicine paste formulation and preparation method for treating diabetes skin damaged |
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Cited By (1)
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| CN107510836A (en) * | 2017-09-15 | 2017-12-26 | 李玉保 | A kind of bitter gourd polypeptide pharmaceutical composition for treating diabetic ulcer and preparation method thereof |
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