CN107028781A - A kind of toothpaste containing eugenol and preparation method thereof - Google Patents
A kind of toothpaste containing eugenol and preparation method thereof Download PDFInfo
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- CN107028781A CN107028781A CN201710217797.4A CN201710217797A CN107028781A CN 107028781 A CN107028781 A CN 107028781A CN 201710217797 A CN201710217797 A CN 201710217797A CN 107028781 A CN107028781 A CN 107028781A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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Abstract
A kind of toothpaste containing eugenol and preparation method thereof.It is related to oral care implement, including eugenol, sorbierite, polyethylene glycol, carboxymethyl cellulose, hydrated silica, glycerine, hydroxyethyl cellulose, saccharin, laruyl alcohol sodium sulfovinate, water, probiotic powder, lactalbumin, methylisothiazolinone；The toothpaste containing eugenol of the invention has the drug effects such as antipyretic-antalgic, anti-inflammatory, anesthesia, additionally with antibacterium, antimycotic, anti-oxidant, anticancer the effects such as, have high therapeutic effect to gingivitis and bleeding gums；Also there is obvious analgesic effect for toothache；Eugenol is added into toothpaste, dentistry analgesia, anesthetic, anti-inflammatory and antalgic is can be widely applied to, toothache can be caused, the effect of resist gingivitis, bleeding gums and pain is more notable；, can effectively pre- anti-caries and eugenol with toothpaste with fluoride ratio the drawbacks of can reduce toothpaste with fluoride.
Description
Technical field
The present invention is to be related to oral care implement, specifically a kind of toothpaste containing eugenol and preparation method thereof.
Background technology
Dental caries (Dental Caries) be under the multifactor impact based on bacterium, dental hard tissue occur it is chronic enter
A kind of disease of row destruction, is a kind of most commonly seen mouth disease；Bacterial plaque is indispensable in dental caries generating process
Micro-ecological environment；The acidic metabolite that bacterial metabolism carbohydrate is produced in bacterial plaque, can cause enamel decalcification, dissolving,
And then form dental caries；Including periodontitis, have a toothache, hemodia etc., these mouth diseases annoying the life of people always；The world
Itself and cancer and angiocardiopathy are listed as endangering three big diseases of human health by health organization；Toothpaste in the market
Species is a lot, and it is generally to extract to natural animal-plant and chemical synthetic drug that it, which is formulated, although these compositions are with certain suppression
Oral cavity harmful bacteria, prevents and treats periodontitis, the effect of anti-inflammatory analgesic；In addition, it is more using toothpaste with fluoride in the market, it is more general
Time, toothpaste with fluoride, which is used for a long time, can cause den tal fluorosis, if the fluoride of long-term intake high dose in addition, may cause cancer,
The problems such as sacred disease and internal system malfunction；Therefore it provides a kind of analgesic effect is more significantly used to treat
Medicated toothpaste of mouth disease and preparation method thereof, becomes one of the problem of art personnel are suddenly to be addressed.
The content of the invention
It is an object of the present invention to overcome the above deficiencies is significantly used for analgesic there is provided a kind of effect containing cloves
Toothpaste of phenol and preparation method thereof.
The technical scheme is that：A kind of toothpaste containing eugenol, its composition of raw materials is by weight percentage：Eugenol
0.5-2.0%, sorbierite 20-60%, polyethylene glycol 5-15%, carboxymethyl cellulose 0.5-1.5%, hydrated silica 12-25%,
Glycerine 12-25%, hydroxyethyl cellulose 0.2-1.0%, saccharin 0.05-0.5%, laruyl alcohol sodium sulfovinate 0.5-5%, water 5-
12%, probiotic powder 0.5-2%, lactalbumin 0.5-2%, methylisothiazolinone 0.005-0.02%.
Preferential, its composition of raw materials is by weight percentage：Eugenol 0.7-1.5%, sorbierite 30-50%, poly- second two
Alcohol 8-12%, carboxymethyl cellulose 0.8-1.2%, hydrated silica 15-20%, glycerine 15-20%, hydroxyethyl cellulose 0.3-
0.8%, saccharin 0.1-0.3%, laruyl alcohol sodium sulfovinate 1-3.5%, water 6.5-10%, probiotic powder 0.6-1.5%, whey egg
White 0.8-1.5%, methylisothiazolinone 0.008-0.015%.
Preferential, its composition of raw materials is by weight percentage：Eugenol 0.9-1.25%, sorbierite 35-45%, poly- second two
Alcohol 9-11%, carboxymethyl cellulose 0.95-1.1%, hydrated silica 16-19%, glycerine 17-19%, hydroxyethyl cellulose 0.4-
0.7%, saccharin 0.15-0.25%, laruyl alcohol sodium sulfovinate 1.5-2.5%, water 7.5-8.5%, probiotic powder 0.8-1.2%,
Lactalbumin 0.9-1.2%, methylisothiazolinone 0.009-0.012%.
Preferential, its composition of raw materials is by weight percentage：Eugenol 1.1%, sorbierite 40%, polyethylene glycol 10%,
Carboxymethyl cellulose 0.9%, hydrated silica 17%, glycerine 18%, hydroxyethyl cellulose 0.5%, saccharin 0.2%, laruyl alcohol sulphur
Acid esters sodium 2%, water 8.29%, probiotic powder 1.0%, lactalbumin 1.0%, methylisothiazolinone 0.01%.
A kind of preparation method of the toothpaste containing eugenol, specific implementation step is as follows：
1), divide metering to feed intake, the kneading of glue, lotion, grinding, vacuum outgas, ageing etc.；Using two-step method production technology,
Above-mentioned steps are completed in same cream pot processed.
2), by spices, active additive, stabilizer, saccharin in pot is pre-dissolved with dissolved in purified water to uniform, add cream processed
Pot, after by the metered cream processed pot of liquid material difference in liquid material storage tank, then plus powder；After powder addition is finished, then add spices,
Carry out scraper plate stirring, homogeneous stirring, grinding；Because in kneading, process of lapping, bubble can be produced in creme, therefore need to carry out simultaneously
Vacuumize, until vacuum reaches 0.096Mpa, the time is about 50 minutes；Kneading effect makes creme be sufficiently mixed uniformly, grinds mesh
Make creme fine and smooth；Mediate after grinding terminates, get a small amount of lotion and test, it is qualified after, then squeeze into lotion storage pot and carry out
Ageing, makes material naturally cool to normal temperature, while making material fully be expanded into homogeneous adherend, improves the elasticity of material, old
The change time is about 120 minutes；During cream processed, because mediating, process of lapping can rub heat release, therefore need to be cooled down in summer with chuck
Water management temperature≤45 DEG C, finally sterilize, dispense.
The present invention chooses following raw material and is used as main composition and its pharmacology explanation：
Eugenol：It is the main component of caryophyllus oil, is a kind of organic phenol；With drug effects such as antipyretic-antalgic, anti-inflammatory, anesthesia,
Additionally there is antibacterium, antimycotic, anti-oxidant, anticancer, mosquito repellent to keep away worm isoreactivity.Its toxic side effect is small simultaneously, Metabolic residue
It is few；It is slightly soluble in water and is soluble in organic solvent, is widely used in dentistry analgesia, anesthetic, anti-inflammatory and antalgic and flavor enhancement etc..Separately
Outside, eugenol has very strong sterilizing power, can be used for carious tooth as Bangesic, and have local antisepsis concurrently.
Sorbierite：It is a kind of widely used industrial chemicals, has extremely wide in industries such as food, daily use chemicals, medicine
Using can be used as sweetener, NMF, excipient, preservative etc., while having the nutritional advantages of polyalcohol, i.e. low-heat
The effects such as value, low sugar, anti-caries；Sorbierite is soluble in water, is insoluble in organic solvent, acidproof, heat-resist, can bear 200 DEG C
High temperature nondiscolouring, is not susceptible to Maillaid braun reaction with amino acid, protein etc. during ingredients, crystalline sorbitol also has good
Compressibility, be widely used as the carrier of tablet.
Polyethylene glycol：Water solubility, fixedness, physiological inertia, mildness, lubricity and make skin moisturizing, softness, have pleased
Sense etc. after fast use.The polyethylene glycol that different relative molecular mass fractions can be chosen changes viscosity, hygroscopicity and the knot of tissue of product
Structure.Low polyethylene glycol (the Mr of relative molecular mass<2000) wetting agent and consistency modifiers are suitable for use as, for cream, emulsion,
Toothpaste and shaving cream etc., are also applied for the Preparation for hair not cleaned, and assigning hair has silk-like sheen.Relative molecular mass is high to be gathered
Ethylene glycol (Mr>2000) it is applied to lipstick, deodorant stick, perfumed soap, shaving soap, foundation cream and cosmetics etc..In cleaning agent, gather
Ethylene glycol also serves as suspending agent and thickener.In pharmaceuticals industry, the matrix as ointment, emulsion, ointment, lotion and suppository.
Carboxymethyl cellulose：Be cellulose carboxymethyl roll into a ball substitution product according to its molecular weight or substitution degree, Ke Yishi
Polymer be completely dissolved or insoluble, the latter can be as weak-type cation-exchanger, to Separation of Neutral or alkaline egg
The such as white matter carboxymethyl celluloses can form highly viscous colloid, solution, have adhesion, thickening, flowing, emulsion dispersion, figuration, guarantor
The characteristic such as water, protecting colloid, film forming, acidproof, salt tolerant, suspended, and physiological harmlessness, therefore in food, medicine, daily use chemicals, stone
Particularly pharmacy industries of being used widely in the production of the fields such as oil, papermaking, weaving, building make tablet from appropriate viscosity CMC
Binder, disintegrant, suspending agent of supensoid agent etc..
Hydrated silica：Hydrated silica is also referred to as pure latex, hydrated SiO 2, white carbon, silicate hydrate, is typically used as paint
Coating filler, rubber reinforcing filler, plastics tackifier and thixotropic agent, the thickening agent of synthetic grease silicone grease.Possess good resistance to
Coefficient is ground, while tooth-whitening, tooth wear degree is preferably minimized.
Glycerine：Glycerine is a kind of colourless or slightly yellow clear viscous liquids, nontoxic, odorless, non-corrosiveness, with stronger
Hygroscopicity, can generate a variety of esters with inorganic acid and organic acid reaction, can form polyglycerol under certain condition.
Hydroxyethyl cellulose：It is a kind of white or faint yellow, tasteless, nontoxic threadiness or pulverulent solids, by alkalescence
Prepared by cellulose and the etherified reaction of oxirane (or chlorethanol), belong to the plain ethers of non-ionic soluble fibre.Because HEC has
The characteristics such as good thickening, suspension, scattered, emulsification, bonding, film forming, protection moisture and offer protecting colloid, have been widely used
In fields such as oil exploitation, coating, building, medicine food, weaving, papermaking and macromolecular polymerization reactions
Saccharin：For white crystalline powder, water is insoluble in, its sodium salt is soluble in water, to thermally-stabilised, sugariness is sucrose
300~500 times, without calorie, it is edible after have slight bitter taste and metallic taste is remained on tongue.
Laruyl alcohol sodium sulfovinate：For white powder, there is characteristic odor, soluble in water, foaming power is strong, and foam is plentiful, clean
In vain, fine and closely woven, it is a kind of foaming agent by also excellent emulsifiability and washability, when brushing teeth mouthful in have many foams, it is main
Be exactly laruyl alcohol sodium sulfovinate in action.
Probiotic powder：The microorganism beneficial to health, can maintain intestinal health to balance, and mainly include Bifidobacterium class
With lactobacillus class, with enteron aisle health care, enhancing is immune, the function such as adjustment effect.
Lactalbumin：PURE WHEY can easily absorb, easy to digest, can improve immune, resisting fatigue is built up health, help
Body detoxifies, and improves sleep, and beauty such as is preserved youthful looks at numerous effects.
Methylisothiazolinone：It is a kind of efficient germicide, heat-resisting waterborne preservative, the growth for suppressing microorganism
There is good effect, the growth of bacterium, fungi, mould and mould can be suppressed, the product can be directly added into use in personal care
The fields such as product, cosmetics, coating, paper pulp.
The beneficial effects of the present invention are：
The toothpaste containing eugenol of the present invention has the drug effects such as antipyretic-antalgic, anti-inflammatory, anesthesia, additionally with anti-thin
The effects such as bacterium, antimycotic, anti-oxidant, anticancer, there is high therapeutic effect to gingivitis and bleeding gums；Also have for toothache
Obvious analgesic effect；Eugenol is added into toothpaste, dentistry analgesia, anesthetic, anti-inflammatory and antalgic is can be widely applied to,
Toothache can make it that, the effect of resist gingivitis, bleeding gums and pain is more notable；And eugenol can with toothpaste with fluoride ratio
The drawbacks of to reduce toothpaste with fluoride, can effectively pre- anti-caries.
Brief description of the drawings
Fig. 1 is physiological saline, the comfortable comparison diagram influenceed up to toothpaste and this present invention on the hot pain threshold of mouse.
Embodiment
Below in conjunction with preferred embodiment, the embodiment, the feature that are provided according to the present invention are described in detail such as with reference to accompanying drawing
Under：
Embodiment 1
A kind of toothpaste containing eugenol, its composition of raw materials is by weight percentage：Eugenol 0.5-2.0%, sorbierite
20-60%, polyethylene glycol 5-15%, carboxymethyl cellulose 0.5-1.5%, hydrated silica 12-25%, glycerine 12-25%, hydroxyl second
Base cellulose 0.2-1.0%, saccharin 0.05-0.5%, laruyl alcohol sodium sulfovinate 0.5-5%, water 5-12%, probiotic powder 0.5-
2%, lactalbumin 0.5-2%, methylisothiazolinone 0.005-0.02%.
The specific preparation process of medicated toothpaste of the present invention is as follows：
1), divide metering to feed intake, the kneading of glue, lotion, grinding, vacuum outgas, ageing etc.；Using two-step method production technology,
Above-mentioned steps are completed in same cream pot processed.
2), by spices, active additive, stabilizer, saccharin in pot is pre-dissolved with dissolved in purified water to uniform, add cream processed
Pot, after by the metered cream processed pot of liquid material difference in liquid material storage tank, then plus powder；After powder addition is finished, then add spices,
Carry out scraper plate stirring, homogeneous stirring, grinding；Because in kneading, process of lapping, bubble can be produced in creme, therefore need to carry out simultaneously
Vacuumize, until vacuum reaches 0.096Mpa, the time is about 50 minutes；Kneading effect makes creme be sufficiently mixed uniformly, grinds mesh
Make creme fine and smooth；Mediate after grinding terminates, get a small amount of lotion and test, it is qualified after, then squeeze into lotion storage pot and carry out
Ageing, makes material naturally cool to normal temperature, while making material fully be expanded into homogeneous adherend, improves the elasticity of material, old
The change time is about 120 minutes；During cream processed, because mediating, process of lapping can rub heat release, therefore need to be cooled down in summer with chuck
Water management temperature≤45 DEG C, sterilize, packing.
Embodiment 2
A kind of toothpaste containing eugenol, its composition of raw materials is by weight percentage：Eugenol 0.7-1.5%, sorbierite
30-50%, polyethylene glycol 8-12%, carboxymethyl cellulose 0.8-1.2%, hydrated silica 15-20%, glycerine 15-20%, hydroxyl second
Base cellulose 0.3-0.8%, saccharin 0.1-0.3%, laruyl alcohol sodium sulfovinate 1-3.5%, water 6.5-10%, probiotic powder
0.6-1.5%, lactalbumin 0.8-1.5%, methylisothiazolinone 0.008-0.015%.
Preparation method be the same as Example 1.
Embodiment 3
A kind of toothpaste containing eugenol, its composition of raw materials is by weight percentage：Eugenol 0.9-1.25%, sorbierite
35-45%, polyethylene glycol 9-11%, carboxymethyl cellulose 0.95-1.1%, hydrated silica 16-19%, glycerine 17-19%, hydroxyl
Ethyl cellulose 0.4-0.7%, saccharin 0.15-0.25%, laruyl alcohol sodium sulfovinate 1.5-2.5%, water 7.5-8.5% are prebiotic
Bacterium powder 0.8-1.2%, lactalbumin 0.9-1.2%, methylisothiazolinone 0.009-0.012%.
Preparation method be the same as Example 1.
Embodiment 4
A kind of toothpaste containing eugenol, its composition of raw materials is by weight percentage：Eugenol 1.1%, sorbierite 40% gathers
Ethylene glycol 10%, carboxymethyl cellulose 0.9%, hydrated silica 17%, glycerine 18%, hydroxyethyl cellulose 0.5%, saccharin
0.2%, laruyl alcohol sodium sulfovinate 2%, water 8.29%, probiotic powder 1.0%, lactalbumin 1.0%, methylisothiazolinone
0.01%.
Preparation method be the same as Example 1.
Remained to ensure that eugenol is added in toothpaste with effect, the product being made has been subjected to analgesia and antibacterial two side
The test of pesticide effectiveness in face.
1.1 analgesic experiment
Application effect：Analgesic activity experiment is the thermostimulation mouse foot for mouse is placed on the hot plate of certain temperature
Pain reaction is produced, that is, licks sufficient reaction；Occur licking sufficient time effect using mouse and judge blank control group as pain reaction indicator
The analgesic effect of (0.2% physiological saline), positive controls (0.2% is comfortable up to toothpaste) and toothpaste group (0.2% this product)；
Test result indicates that, control group and toothpaste group in analgesic effect than blank group effect substantially, from statistically comparing
Compared with this product has more significant analgesic effect.
Screen qualified mouse 30 (having the mouse of pain reaction in 20~25g females and 30s) and be randomly divided into 3 groups, be respectively
Blank control group (0.2% physiological saline), positive controls (0.2% comfortably reaches toothpaste) and toothpaste group (0.2% this product) are each
10.Belly shaving 3cm × 3cm, each group smears 2g physiological saline, comfortably up to toothpaste, this product in belly respectively after 48 hours
Skin, 15min, 30min, 45min, 60min after before smearing and smearing respectively survey pain threshold once respectively, and remember
Record pain threshold；Mouse is put in into constant temperature hot plate (55 ± 0.3 DEG C) again to be tested.
Improve percentage=(average pain threshold before evenly heat pain threshold-smearing after smearing)/average threshold of pain before smearing in the threshold of pain
Value × 100%
The physiological saline of table 1, comfortably reach the influence of toothpaste, this product to mouse pain threshold
The mouse of table 2 smears physiological saline, comfortably up to toothpaste, this product pain threshold raising percentage (%)
| Group | 15min | 30min | 45min | 60min |
| Physiological saline | 7.91 | 3.17 | 1.57 | 3.00 |
| Comfortably reach toothpaste | 136.00 | 92.70 | 87.08 | 66.67 |
| This product | 190.55 | 116.75 | 165.70 | 159.69 |
Result of the test：As shown in Figure 1, in experimentation, preceding 30min is comfortably up to toothpaste group and the heat pain of this product group mouse
Threshold value has obvious difference, and 30min~60min has significant difference (P<0.05).
Conclusion：Test result indicates that, positive controls and this product more lick foot instead with blank control group to hot plate mouse
Should have obvious analgesic activity, from this product in statistical data can faster analgesic activity, duration length and effect is obvious.
1.2 bacteriostatic experiment
Application effect：It is right that bacteriostatic experiment mainly compares blank control group (0.2% physiological saline), the positive by paper disk method
According to group (0.2% comfortable reach at toothpaste) and toothpaste group (0.2% this product) to staphylococcus, streptococcus, lactobacillus acidophilus sterilizing
Effect.
1st, with nine culture mediums of distilled water implement and making.
2nd, after appropriate dilution bacterium colony culture medium, 0.1ml bacterium solutions is respectively taken, nine cultures are inoculated into respectively using spread plate method
On base.
3rd, nine culture mediums are numbered, and is divided into blank control group, positive controls, three groups of toothpaste group.
4th, 18 a diameter of 2cm disk, 6 bubble blank control groups (0.2% physiological saline), 6 bubbles are detected with filter paper
Positive controls (0.2% comfortably reaches toothpaste), 6 bubble toothpaste groups (0.2% this product).After the completion of be attached on culture medium, every training
Support base and paste 2.
5th, by the medium culture for carrying out mark for a period of time, bacterial growth situation is observed.
6th, flat board is taken out, antibacterial circle diameter size is measured, and make a record.
(note：Inhibition zone radius is designated as R1, and wafer radius 1cm is designated as R2)
Experimental result：As shown in Table 3, positive controls and toothpaste group antibacterial circle diameter and average have to blank control group
Significant difference, toothpaste group antibacterial circle diameter and average have obvious difference to positive controls.
Conclusion：Test result indicates that this product has preferable fungistatic effect to staphylococcus, streptococcus, lactobacillus acidophilus.
Claims (5)
1. a kind of toothpaste containing eugenol, it is characterised in that its composition of raw materials is by weight percentage：Eugenol 0.5-2.0%,
Sorbierite 20-60%, polyethylene glycol 5-15%, carboxymethyl cellulose 0.5-1.5%, hydrated silica 12-25%, glycerine 12-
25%, hydroxyethyl cellulose 0.2-1.0%, saccharin 0.05-0.5%, laruyl alcohol sodium sulfovinate 0.5-5%, water 5-12% are prebiotic
Bacterium powder 0.5-2%, lactalbumin 0.5-2%, methylisothiazolinone 0.005-0.02%.
2. a kind of toothpaste containing eugenol according to claim 1, it is characterised in that its composition of raw materials is by weight percentage
For：Eugenol 0.7-1.5%, sorbierite 30-50%, polyethylene glycol 8-12%, carboxymethyl cellulose 0.8-1.2%, are hydrated silicon
Stone 15-20%, glycerine 15-20%, hydroxyethyl cellulose 0.3-0.8%, saccharin 0.1-0.3%, laruyl alcohol sodium sulfovinate 1-
3.5%, water 6.5-10%, probiotic powder 0.6-1.5%, lactalbumin 0.8-1.5%, methylisothiazolinone 0.008-
0.015%.
3. a kind of toothpaste containing eugenol according to claim 1, it is characterised in that its composition of raw materials is by weight percentage
For：Eugenol 0.9-1.25%, sorbierite 35-45%, polyethylene glycol 9-11%, carboxymethyl cellulose 0.95-1.1%, hydration
Silica 16-19%, glycerine 17-19%, hydroxyethyl cellulose 0.4-0.7%, saccharin 0.15-0.25%, laruyl alcohol sodium sulfovinate
1.5-2.5%, water 7.5-8.5%, probiotic powder 0.8-1.2%, lactalbumin 0.9-1.2%, methylisothiazolinone
0.009-0.012%.
4. a kind of toothpaste containing eugenol according to claim 1, it is characterised in that its composition of raw materials is by weight percentage
For：Eugenol 1.1%, sorbierite 40%, polyethylene glycol 10%, carboxymethyl cellulose 0.9%, hydrated silica 17%, glycerine
18%, hydroxyethyl cellulose 0.5%, saccharin 0.2%, laruyl alcohol sodium sulfovinate 2%, water 8.29%, probiotic powder 1.0%, breast
Albumin 1.0%, methylisothiazolinone 0.01%.
5. a kind of a kind of preparation method of the toothpaste containing eugenol as claimed in claim 1, it is characterised in that
1), divide metering to feed intake, the kneading of glue, lotion, grinding, vacuum outgas, ageing etc.；It is above-mentioned using two-step method production technology
Step is completed in same cream pot processed；
2), by spices, active additive, stabilizer, saccharin in pot is pre-dissolved with dissolved in purified water to uniform, add cream pot processed,
Afterwards by the metered cream pot processed of the liquid material difference in liquid material storage tank, then add powder；After powder addition is finished, then spices is added, entered
The stirring of row scraper plate, homogeneous stirring, grinding；Vacuumized simultaneously, until vacuum reaches 0.096Mpa, the time is about 50 minutes；
Mediate after grinding terminates, get a small amount of lotion and test, it is qualified after, then squeeze into lotion storage pot and be aged, make material oneself
Normal temperature so is cooled to, while making material fully be expanded into homogeneous adherend, digestion time is about 120 minutes.
3), sterilize, dispense.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111888315A (en) * | 2020-09-10 | 2020-11-06 | 山东钰财农业发展有限公司 | Preparation method of black garlic toothpaste |
| CN112168721A (en) * | 2020-09-16 | 2021-01-05 | 海南大学 | Chinese herbal medicine toothpaste containing clove and alpinia oxyphylla volatile oil and preparation method thereof |
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Application publication date: 20170811 |