CN106963790A - A kind of manufacture craft of use ultra micro nanometer technology ganoderma spove powder - Google Patents
A kind of manufacture craft of use ultra micro nanometer technology ganoderma spove powder Download PDFInfo
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- CN106963790A CN106963790A CN201710270623.4A CN201710270623A CN106963790A CN 106963790 A CN106963790 A CN 106963790A CN 201710270623 A CN201710270623 A CN 201710270623A CN 106963790 A CN106963790 A CN 106963790A
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- powder
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- ganoderma spove
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
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Abstract
The present invention relates to a kind of manufacture craft of use ultra micro nanometer technology ganoderma spove powder, broken wall is carried out using physics mode, the composition of lucidum spore powder is not destroyed, other impurity are not contained, and the original flavor of lucidum spore powder can be kept well, broken wall efficiency high, shell-broken effect are good, broken wall uniform and complete, sporoderm-broken rate is up to more than 99%, then by ultra micro nanotechnology treatments, sterilized by Co 60, it is ensured that safe and effective for medication.
Description
Technical field
The invention belongs to field of medicinal materials processing, more particularly to a kind of system of use ultra micro nanometer technology ganoderma spove powder
Make technique.
Background technology
Long ago, the first ancestor Yan Di, also known as Shen Nong, a legendary ruler of the Chinese nation has a lovely daughter, is named as a precious jade Ji for legend.She has one
Vast love, for national healthy and happiness, her smart soul has been turned into a celestial grass.This celestial grass has the work(of mystery
Effect, can cure all kinds of diseases and ailments, come back to life, prolong life.This celestial grass is exactly ganoderma lucidum, and also known as refreshing sesame, ancients regard seocho as.Pass
Say and teach that, ganoderma lucidum is the commensal of the Chinese nation, and the native place of ganoderma lucidum is in China.Song Dynasty Li Shi et al. is write《Peace is for the emperor's inspection》
In one book, it refer to《Celestial being ganoderma lucidum is schemed》Description.China (takes, salubrity to the understanding (being born in rotten wood) of ganoderma lucidum and utilization
It is healthy and strong) B.C. Yao's generation in 2100 may be started from the latest.The China collected in Warring states' last years of a dynasty or reign (before 221 B.C.) is most
Early dictionary《It is elegant》In《Release grass》A piece just has " mattress ", the solution of " sesame ", people from Shanxi Guo Shi note clouds：" sesame, one-year-old three China, seocho.”
Han dynasty has been arrived, has occurred in that ganoderma lucidum worships that Emperor Wu Di of the Han dynasty is close in sweet spring water temple palace sets ganoderma lucidum, expresses one's congratulations.Ganoderma lucidum enters classic section of China
Learn the visual field.The first medicine classics of China of the Eastern Han Dynasty into book《Sheng Nong's herbal classic》Ganoderma lucidum is classified as in medicine " top grade ".Arrive
The Ming Dynasty, great medicine scholar Li Shizhen (1518-1593 A.D.) summarizes the medicine of ganoderma lucidum with authority with its erudite knowledge and abundant clinical experience
Effect is managed, these effects confirm for current institute of pharmacology.Version in 2000《Pharmacopoeia of People's Republic of China》Ganoderma lucidum is recorded
(red sesame, purple sesame), has affirmed the medical value of ganoderma lucidum, in recent years《U.S.'s herbal medicine allusion quotation》Also ganoderma lucidum has been recorded.The pharmacology of ganoderma lucidum is lived
Property be mainly shown as antitumor action, immunoregulation effect, resisting oxidation free radical effect, hypoglycemic effect, hypotensive activity, adjust
Save blood fat, antiallergy, antiasthmatic effect, hepatoprotective effect, oxygen lack resistant function, anti-aging effects and anti-radiation effect etc..
Nanometer technology is also referred to as nanotechnology, is the property of research structure size material in 0.1 nanometer to 100 nanometer ranges
With a kind of technology of application.The research and application of current nanometer technology are main in terms of biotechnology and agricultural product.And ultra micro
Nanometer technology is the science and technology that material is manufactured with single atom, molecule, and research structure size is in 0.1 to 100 nanometer range
The property of material and application.Ultra micro nanoscale science and technology is the science and technology based on modern advanced science and technology, and it is existing
The product combined for science (quantum mechanics, molecular biology) and modern technologies (computer technology), ultra micro nanoscale science and technology
A series of new science and technology will be triggered again, such as nanobiology, nanophysics, nanochemistry.
Lucidum spore powder have passed through after broken wall, obtain ganoderma spove powder, then using ultra micro nanometer technology, will more
Medical treatment, healthcare field are used in well, are that the mankind prevent and cure diseases, bigger contribution is made in the health that complies with one's wishes.
The content of the invention
It is according to thin it is an object of the invention to provide a kind of manufacture craft of ultra micro nanometer technology ganoderma spove powder
The mechanical and physical property of cell wall, using the Volume Changes principle of water and ethanol in phase transition process in micro, and is designed
A kind of method that spore cell wall is carried out to microscopic techniques opening, then carry out after ultra micro nanotechnology treatments, gone out by Co 60
Bacterium, it is ensured that safe and effective for medication.
The purpose of the present invention is to be achieved through the following technical solutions：
A kind of ultra micro nanometer technology ganoderma spove powder manufacture craft is the method using heating by lucidum spore powder
Micropore on cell membrane is opened, and lucidum spore powder is then carried out into pressurization immersion in water (may use ethanol water), made
The enough hydrones (ethanol molecule) of the intracellular suction of lucidum spore powder are obtained, are then carried out at the fast freezing and crystallizing of low temperature low speed
Reason, using the Volume Changes principle of water and ethanol molecule in phase transition process in micro, cell membrane is burst, then will be cold
The conidia powder of jelly carries out low temperature and rapidly expansion drying in high vacuum and heating environment, is beaten so that cell membrane thoroughly be destroyed
Open, then carry out ultra micro nanotechnology treatments, sterilized through Co 60, it is ensured that safe and effective for medication.
Embodiment
Step 1: conidia powder is heated to the regular hour under vacuum to remove intracellular air and moisture, with
Just intracellular osmotic pressure is reduced, while the micropore on cell membrane can be opened tentatively.
Step 2: conidia powder is soaked in water or ethanol water under an increased pressure so that hydrone (and ethanol point
Son) Reishi sporule cell interior is entered by the micropore and permeable pressure head on cell membrane.
Step 3: the conidia powder after the water suction of breaking vacuum relief is by slow freezing, to allow intracellular hydrone progressively
Form ice crystal, volume increase is progressively burst cell membrane, reached comprehensively and the effect of uniform spore cell broken wall.
Step 4: the mixture of freezing is rapidly heated under vacuum, intracellular and hydrone can rapidly gasify,
Huge steam air pressure is produced inside spore cell, and passes through cell membrane at a terrific speed, tear is not opened completely
Cell wall structure, or the cell membrane micropore having already turned on further is torn, reaches the effect that complete broken wall is carried out to cell
Really.
Step 5: the temperature of product slowly is gradually heated into certain temperature, until being completely dried.Then closed appearance is abolished
Vacuum in device, the exosporium-broken spore dried.
Step 6: being sterilized again after row ultra micro nanotechnology treatments through Co 60, it is ensured that safe and effective for medication.
Ultra micro nanometer technology ganoderma spove powder technique of the present invention has the beneficial effect that：According to water and ethanol point
Volume Changes principle of the son in phase transition process in micro, carries out broken wall using physics mode, does not destroy Reishi sporule
The composition of powder, does not contain other impurity, and the original flavor of lucidum spore powder can be kept well, and broken wall efficiency high, shell-broken effect are good, breaks
Wall uniform and complete, sporoderm-broken rate sterilizes up to more than 99%, then by ultra micro nanotechnology treatments by Co 60, total plate count, big
Intestinal flora, mould, pathogenic bacteria are without detection, it is ensured that safe and effective for medication.
Conidia powder is placed in a closed container, using equipment such as vavuum pumps by container vacuum pumping, vacuum exists
Between 500~600, conidia powder is heated to 50~60 degree in the state of vacuum, this state is kept 5~25 minutes.So may be used
To reduce intracellular osmotic pressure, and most of air in spore cell is taken away, tentatively open micro- on some cell membranes
Hole, readily hydrone to be allowed to enter cell interior in next step.
During concrete operations, it can will be adjusted the heat time according to conidia powder amount, also can be while heating to conidia powder
It is stirred, is pumped so as to the air for making conidia powder intracellular faster, evenly, is also beneficial to the micropore on cell membrane
Open.
Pure water or 0~50% ethanol solution are added in the closed container under vacuum condition so that conidia powder is dissolved in
In pure water or 0~50% ethanol water, and by the volume of pure water or 0~50% ethanol solution in container by
Step increase is to be stepped up the pressure in container so that hydrone (and ethanol molecule) by the micropore on cell membrane or can ooze
Saturating pressure difference enters Reishi sporule cell interior.During this, mechanical stirring device can be used to improve and accelerate spore in container
The mixing of sub- powder and solution.Kept for 1~100 minute after pressure reaches 10~100 atmospheric pressure, there are enough hydrones
Into intracellular.
After solution discharge in container is fallen, by the moist conidia powder in container in container by progressively slow freezing.Drop
Warm speed, until whole mixture speed knot completely, is kept for 5 to 60 minutes in 0.1~2 centigrade per minute.Final temperature is zero
Between lower 10~80 degree.
In this slow freezing process, ICW can progressively form ice crystal.Ice crystal proportion is smaller than aqueous water,
Volume can increase.The increase of ice crystal volume can progressively burst cell membrane, reach comprehensively and the effect of uniform spore cell broken wall.
Stop refrigeration, the space in closed container is vacuumized and is maintained between 500~600 vacuums.Start fast
Material is heated rapidly to 30~45 degrees centigrades by fast heater, and programming rate should be in 5~20 centigrade per minutes.One
Vacuum in straight holding container is extracted out until no excessive moisture.
In the environment of condition of high vacuum degree, the moisture of cell interior can very fast gasification, produced inside spore cell huge
Steam air pressure.Under the driving of pressure differential inside and outside cell membrane, steam can be worn at a terrific speed through row outside cell membrane, tear
There is no full opening of cell wall structure, or the cell membrane micropore having already turned on further is torn, reach and cell has been carried out
Full shell-broken effect.
After not unnecessary moisture is extracted out, the temperature of product is slowly gradually heated to 70~80 degrees Celsius, heating speed
In 1~5 centigrade per minute, finally product is kept for 5~25 minutes under 70~80 degree celsius temperatures, until being completely dried.
Then the vacuum in closed container is abolished, dry spore powder with crushed sporoderm is taken out.Slow temperature-rise period ensures conidia powder
Interior moisture can be driven away completely, have an impact without the activity to the active material in product.
The dry spore powder with crushed sporoderm taken out, by ultra micro nanometer technology particle electronic pattern explosive method technique, volume
Determine 220~50HZ of voltage, 8~80W of rated power, obtain nanoscale spore powder with crushed sporoderm.
After packaging, sterilized by Co 60, the dosage of Co 60 sterilizing is 6kgy, it is ensured that product total plate count, coliform, mould
Bacterium, pathogenic bacteria are safe and effective for medication without detection.
Those of ordinary skill in the art it should be appreciated that the embodiment of the above be intended merely to explanation the present invention,
And the restriction of the present invention is not intended as, as long as in the spirit of the present invention, change, change to embodiment described above
Type is all dropped within scope of the presently claimed invention.
Claims (6)
1. a kind of method that use nanometer technology ganoderma spove powder makes, it is characterised in that including following operating procedure：
(1) by purified water under conditions of stirring, Reishi sporule powder raw material is added, the Reishi sporule powder raw material and purified water
Mass ratio is 1:2~1:10, Reishi sporule powder raw material is dispersed in water；
(2) stand, remove upper foam shape floating object, discard precipitation；Middle interstitial fluid is filtered to remove impurity, filtered fluid is obtained；
(3) by filtered fluid press filtration, filter cake is obtained；
(4) filter cake is crushed, it is 10 to add with filter cake quality ratio:1~1:1 purified water, is well mixed, obtains suspension；
(5) suspension is subjected to vacuum freezedrying, obtains lucidum spore powder；The method of the vacuum freezedrying is：Will be mixed
Suspension is scattered to be loaded in disk, vacuumizes 1~60pa, and filling nitrogen is cooled to 0 DEG C~-35 DEG C, holding 0.5~4 is small in advance to atmospheric pressure
Shi Hou, vacuumizes 1~60pa, and heating sublimation is to 0 DEG C~10 DEG C, then is cooled to 0 DEG C~-50 DEG C, makes suspension cold junction into ice cube
Solid, is kept for 1~15 hour；1~60pa is vacuumized again, and heating sublimation leads to nitrogen to 10~80pa, treats thing after 15~30 hours
Material temperature degree rises to 40 DEG C -- 45 DEG C, it is incubated to 2~16 hours, discharging.
(6) by above-mentioned resulting discharging, i.e. lucidum spore powder, with extraordinary wall-breaking machine broken wall 2 times, sporoderm-broken rate reaches 99%.
(7) by the ganoderma spove powder obtained by appeal, using the side of ultra micro nanometer high frequency oscillation automatic turning fabrication techniques
Formula, charge is 19~21L, and inlet amount is 2500~4000g/ times, and amplitude is 4~5.5mm, and ultra micro nanometer mode is received for ultra micro
The automatic turning vibrations of rice high frequency oscillation are ground, and dielectric rod returns power for 5~6G, you can obtained using ultra micro nanometer high frequency oscillation certainly
The ganoderma spove powder of dynamic turnover technology.
2. according to claim 1, it is characterised in that：Step：(1) water is purified water.
3. according to claim 1, it is characterised in that：Step：(2) filtering is the stainless steel using the mesh of 80 mesh~500
Sieve, gauze, cotton, silk are filtered.
4. according to claim 1, it is characterised in that：Step：(2) time of the standing is 15 minutes~3 hours.
5. according to claim 1, it is characterised in that：Step：(3) press filtration is the sky using 1~30um apertures filter membrane
Air pressure filter carries out press filtration.
6. according to claim 1, it is characterised in that：Step：(4) crushing is to carry out powder using oscillating granulator
It is broken.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710270623.4A CN106963790A (en) | 2017-04-24 | 2017-04-24 | A kind of manufacture craft of use ultra micro nanometer technology ganoderma spove powder |
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| CN201710270623.4A CN106963790A (en) | 2017-04-24 | 2017-04-24 | A kind of manufacture craft of use ultra micro nanometer technology ganoderma spove powder |
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| CN106963790A true CN106963790A (en) | 2017-07-21 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107550947A (en) * | 2017-08-23 | 2018-01-09 | 安徽芝神堂药业有限公司 | Method for breaking trachytectum of glossy ganoderma |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101703531A (en) * | 2009-11-13 | 2010-05-12 | 广州宝兴生物科技有限公司 | Method for refrigerating, vacuum-drying and purifying ganoderma spore powder |
| CN101768554A (en) * | 2008-12-31 | 2010-07-07 | 胡如军 | Technological method for breaking cell walls of ganoderma lucidum spore powder |
| CN102793728A (en) * | 2012-08-24 | 2012-11-28 | 安徽哈博药业有限公司 | High-frequency oscillation wall-broken ganoderma lucidum spore powder |
| CN106109507A (en) * | 2016-08-08 | 2016-11-16 | 孙继勇 | A kind of manufacture method of ultra micro nanometer Ganoderma spore powder with cellular wall broken |
-
2017
- 2017-04-24 CN CN201710270623.4A patent/CN106963790A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101768554A (en) * | 2008-12-31 | 2010-07-07 | 胡如军 | Technological method for breaking cell walls of ganoderma lucidum spore powder |
| CN101703531A (en) * | 2009-11-13 | 2010-05-12 | 广州宝兴生物科技有限公司 | Method for refrigerating, vacuum-drying and purifying ganoderma spore powder |
| CN102793728A (en) * | 2012-08-24 | 2012-11-28 | 安徽哈博药业有限公司 | High-frequency oscillation wall-broken ganoderma lucidum spore powder |
| CN106109507A (en) * | 2016-08-08 | 2016-11-16 | 孙继勇 | A kind of manufacture method of ultra micro nanometer Ganoderma spore powder with cellular wall broken |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107550947A (en) * | 2017-08-23 | 2018-01-09 | 安徽芝神堂药业有限公司 | Method for breaking trachytectum of glossy ganoderma |
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| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170721 |
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