CN106937642A - A kind of medicament composition of the mite of azoles containing second nitrile - Google Patents

Abstract

The invention discloses the medicament composition of a kind of mite nitrile of azoles containing second and MTI-446, clothianidin, Diacloden, thiacloprid, imidacloprid, Acetamiprid or Nitenpyram, common formulations are made with suitable agricultural agent by active ingredient second azoles mite nitrile and MTI-446, clothianidin, Diacloden, thiacloprid, imidacloprid, Acetamiprid or Nitenpyram.Significantly, there is notable synergistic effect, can reduce dosage in the present invention, delay the resistance to the action of a drug of single medicament, economic, efficient, environmental protection to the crop control of pest mite such as European red mite effect between two medicaments.

Description

A kind of medicament composition containing ethifenacil

technical field

The invention belongs to the field of chemical control of pests and mites, and in particular relates to a medicament composition containing ethifenapyr.

Background technique

Ethafenac, chemical name: (z)-2-(4-tert-butylphenyl)-2-cyano-1-(1-ethyl-3-methylpyrazol-5-yl)vinyl -2,2-Dimethyl propionate is a compound with high acaricidal activity discovered by Shenyang Sinochem Pesticide Chemical Research and Development Co., Ltd. after the transformation of pyrafen-diclofen as the lead compound. It is effective against bees, birds, fish, and silkworms. Low toxicity, effective in preventing and controlling citrus spider mites, apple spider mites, cotton spider mites and vegetable spider mites.

Neonicotinoid insecticides include clothianidin, dinotefuran, thiamethoxam, imidacloprid, nitenpyram, acetamiprid, etc. It has good control effect on Homoptera pests and mites.

Compounding different types of insecticides and acaricides can improve the control effect, expand the scope of control, and save the cost of medication. At present, there is no correlation between the mixture of ethifenapyr and neonicotinoid insecticides for the control of mites. reports.

Contents of the invention

The object of the present invention is to provide a pharmaceutical composition containing ethifenacil, which can be made into a compound preparation to prevent and control crop pest mites, with good effect and low dosage; Methods.

The technical scheme that the present invention adopts is as follows:

A medicament composition containing ethifenac, characterized in that: it consists of active ingredients A and B and auxiliary materials, wherein the active ingredient A is ethifenacil, and the active ingredient B is dinotefuran, clothianidin, clothianidin One of oxazine, thiacloprid, imidacloprid, nitenpyram, acetamiprid.

The pharmaceutical composition containing ethifenac is characterized in that: in the pharmaceutical composition, the mass ratio of active ingredient A to active ingredient B is 40:1-1:40.

The pharmaceutical composition containing ethifenac is characterized in that: in the pharmaceutical composition, the mass ratio of active ingredient A to active ingredient B is 10:1-1:10.

The pharmaceutical composition containing ethifenac is characterized in that: the dosage form of the pharmaceutical composition is emulsifiable concentrate, suspension concentrate, water-dispersible granule, wettable powder, and microcapsule suspension concentrate.

How to use: The preparation can be used for conventional spraying, misting, and root irrigation, or it can be diluted and sprayed on a large area with hot fog machines, airplanes and other machinery to reduce the occurrence of harmful mites.

Beneficial effects of the present invention:

Compared with the prior art, the medicament composition of the present invention has the following beneficial effects: (1) Compared with a single agent, the composition has obvious synergistic effects on pests and mites, significantly improves the control effect, and significantly reduces the cost of medication; (2) It is not easy for pests and mites to develop resistance to this agent, and it also inhibits the resistance of pests to other pesticides; (3) It has both quick-acting and long-acting functions against pests and mites; (4) It can greatly reduce The amount of application in the field can effectively reduce environmental pollution and pesticide residues; (5) Compared with other commonly used pesticides, the cost of production and use is reduced; (6) One drug can treat multiple diseases, and one application can control multiple pests at the same time, reducing the labor cost of prevention and control (7) Reduced toxicity to other non-target organisms.

Experimental data

Indoor bioassay method was used.

Firstly, the co-toxicity coefficients of the compound agents with different ratios on cotton spider mites were obtained through indoor bioassays, and then the control effect was clarified through field efficacy tests to determine the formula ratio and optimal dosage of the compound agents.

Indoor bioassay: slide dipping method was used.

The formula with synergistic effect obtained from laboratory bioassay was made into emulsifiable concentrate (EC), suspoemulsion (SE), wettable powder (WP), water dispersible granule (WDG) and microcapsule suspension concentrate (CS) for testing.

Table 1, Table 2, Table 3, Table 4, Table 5, Table 6, and Table 7 respectively provide etofenil and dinotefuran, clothianidin, thiamethoxam, thiacloprid, imidacloprid, and nitenpyrid Toxicity of amine and acetamiprid compound to apple red spider mite.

Table 1 Toxicity of the mixture of ethifenapyr and dinotefuran to apple spider mite

Table 2 Toxicity of the mixture of ethifenapyr and clothianidin to apple spider mite

Table 3 Toxicity of the mixture of ethifenapyr and thiamethoxam to apple spider mite

Table 4 Toxicity of the mixture of ethifenapyr and thiacloprid to apple red spider

Table 5 Toxicity of the mixture of ethifenapyr and imidacloprid to red spider mite

Table 6 Toxicity of the mixture of ethifenapyr and nitenpyram to apple spider mite

Table 7 Toxicity of the mixture of ethifenapyr and acetamiprid to apple spider mite

From Table 1 to Table 7, it can be seen that ethifenapyr and dinotefuran, clothianidin, thiamethoxam, thiacloprid, imidacloprid, acetamiprid, and nitenpyram are in the range of 40:1~1:40 Both showed good synergistic effect on apple spider mite.

detailed description:

Ethofenazole and dinotefuran, clothianidin, thiamethoxam, thiacloprid, imidacloprid, acetamiprid, nitenpyram are added in different proportions, such as excipients, wetting agents, fillers and other additives , made emulsifiable concentrate, suspoemulsion, water dispersible granule, wettable powder, microcapsule suspension and other dosage forms. In order to illustrate the effect, the following examples 1 to 7 are used for further illustration, but not limited thereto.

Example 1 (22% Ethofenazole·Dinotefuran Suspension Concentrate)

Raw material formula: by mass percentage

Active Ingredient Ethofenazole 2%

Active ingredient Dinotefuran 20%

Sodium lignosulfonate 3%

BY120 2%

600# 2%

Xanthan Gum 0.15%

Propylene Glycol 1%

water balance.

The preparation method is as follows:

According to the formula, the components are weighed in proportion, added to a ball mill and milled for 30 minutes, filtered, pumped into a dispersion tank for 3 minutes at high speed and then fully ground by a sand mill to control the particle diameter of the solid component within 2 microns. After grinding Stir evenly to obtain the suspension concentrate product.

Example 2 (30% Ethafen-clothianidin EC)

Raw material formula: by mass percentage

Active Ingredient Etofen Fenox 15%

Active ingredient Clothianidin 15%

Xylene 20%

DMF 2%

Anhydrous Calcium Salt 5%

Tween 80 5%

Carbon tetrachloride balance.

Preparation method: fully dissolve the active component in xylene, stir well, add anhydrous calcium salt and Tween 80, then use solvent DMF to adjust the content, and use carbon tetrachloride to adjust the balance.

Example 3 (36% ethifenac·thiamethoxam water dispersible granules)

Active Ingredient Ethofenazole 18%

Active ingredient Thiamethoxam 18%

Calcium methyl fatty acid amides benzene sulfonate 4%

Sodium carbonate 3%

Sodium lignosulfonate 4%

Attapulgite margin.

Preparation method: Mix ethifenacil, thiamethoxam, calcium methyl fatty acid amides sulfonate, sodium carbonate, and attapulgite together uniformly, and then pulverize with a jet mill to a particle size of 5 µm to obtain the mother powder. Fully mixed with sodium lignosulfonate, granulated, dried, and sieved to obtain water-dispersible granules.

Example 4 (55% ethiclofen-thiacloprid wettable powder)

Active Ingredient Ethofenazole 5%

Active ingredient Thiacloprid 50%

Wood sodium 4.7%

Ammonium carbonate 3%

Silica 10%

Attapulgite margin.

Preparation method: uniformly mix the above-mentioned substances, and pulverize the mixture through a jet mill to obtain a wettable powder.

Example 5 (11% ethifenac imidacloprid microcapsule suspension)

Active Ingredient Ethofenazole 1%

Active ingredient Imidacloprid 10%

Dimethylformamide 2%

Diphenylmethane diisocyanate 3%

Fatty Amide N-Methyl Taurine Sodium Salt 2%

Ethylenediamine 0.5%

Gum Arabic 2%

Polyvinyl alcohol 2%

Water fill up to 100%

(1) Dissolve the agent in the solvent, add diphenylmethane diisocyanate and stir evenly to obtain the oil phase; (2) Add emulsifier and auxiliary agent to the water and stir evenly to obtain the water phase; (3) Add the water phase to the oil phase , high-speed homogenization to form an oil-in-water emulsion; (4) Under the condition of 450 rpm, add ethylenediamine to participate in the interfacial polymerization reaction, the reaction temperature rises to 55 ° C, and keep for 3 hours to solidify into capsules; (5) Add disperse Agent, thickener, stir evenly to make microcapsule suspension.

Example 6 (41% ethifenac-nitenpyram suspension concentrate)

Raw material formula: by mass percentage

Active Ingredient Ethofenazole 1%

Active ingredient Nitenpyram 40%

Sodium lignosulfonate 3%

A-105 2%

600# 2%

Xanthan Gum 0.15%

Propylene Glycol 1%

water balance.

The preparation method is as follows:

According to the formula, the components are weighed in proportion, added to a ball mill and milled for 30 minutes, filtered, pumped into a dispersion tank for 3 minutes at high speed and then fully ground by a sand mill to control the particle diameter of the solid component within 2 microns. After grinding Stir evenly to obtain the suspension concentrate product.

Example 4 (33% ethifenac acetamiprid wettable powder)

Active Ingredient Ethofenazole 3%

Active ingredient Thiacloprid 30%

Wood sodium 3.7%

Ammonium carbonate 3%

Silica 10%

Attapulgite margin.

Preparation method: uniformly mix the above-mentioned substances, and pulverize the mixture through a jet mill to obtain a wettable powder.

The method of using the above-mentioned pesticide composition to prevent and control harmful mites is to add water to form a suspension for spraying during the occurrence period of harmful mites, so as to prevent and control pests and mites. The medicinal composition disclosed by the invention also has remarkable effects on homopteran pests such as rice planthopper and whitefly. In the present invention, the prepared medicament can be diluted by 500-5000 times, and can be conventionally sprayed and misted, or large-scale spraying can be carried out by using large machines such as hot fog machines and airplanes, so as to reduce the occurrence of pests and mites such as spider mites.

Claims (4)

1. a kind of medicament composition of the mite of azoles containing second nitrile, it is characterised in that：It is made up of effective constituents A and B and auxiliary material, wherein effectively Composition A is second azoles mite nitrile, and active ingredient B is MTI-446, clothianidin, Diacloden, thiacloprid, imidacloprid, Nitenpyram, Acetamiprid In one kind.

2. a kind of medicament composition of the mite of azoles containing second nitrile according to claim 1, it is characterised in that：The medicament composition In, effective constituents A and active ingredient B mass ratio are 40:1-1:40.

3. a kind of medicament composition of the mite of azoles containing second nitrile according to claim 1, it is characterised in that：The medicament composition In, effective constituents A and active ingredient B mass ratio are 10:1-1:10.

4. a kind of medicament composition of the mite of azoles containing second nitrile according to claim 1, it is characterised in that：The medicament composition Formulation be missible oil, suspending agent, water-dispersible granules, wettable powder, microcapsule suspending agent.