CN106924198A - Doxycycline hydrochloride oral disintegrating tablet for domestic fowls and preparation method thereof - Google Patents

Abstract

The present invention relates to a kind of doxycycline hydrochloride oral disintegrating tablet for domestic fowls and preparation method thereof, its constituent component and its parts by weight are respectively：Doxycycline Hyclate 30-150 parts, microcrystalline cellulose 60-150 parts, low-substituted hydroxypropyl cellulose 25-60 parts, lactose 50-120 parts, aspartame 30-100 parts, 10-30 parts, saccharin sodium 0.3-1 parts, magnesium stearate 1-3 parts of fresh milk king's essence.Production equipment of the present invention is simple, operation is easy, weight differential is small, low cost, the routine that oral disnitegration tablet is only produced with lyophilized technique is broken, oral disnitegration tablet is produced by opening the domestic pelleting pressed-disc technique using general powder, it is the important breakthrough of domestic oral formulations process technology, is that domestic veterinary drug market treatment acute disease opens new way.

Description

Doxycycline hydrochloride oral disintegrating tablet for domestic fowls and preparation method thereof

Technical field

The invention belongs to field of medicine preparing technology, especially a kind of livestock and poultry Doxycycline Hyclate mouthful Cavity disintegrating tablet and preparation method thereof.

Background technology

With developing rapidly for China's livestock and poultry breeding industry and continuing to develop for veterinary drug research, antibiotic exists Application on the various disease treatment of infection of livestock and poultry has been formed generally, to improving the survival rate of livestock and poultry and being good for The effectively control and treatment of Kang Shuiping and disease all serves positive role.Doxycycline Hyclate is four Ring element class antibiotic, antimicrobial spectrum is similar to other Tetracyclines, in vitro and in vivo antibacterial activity compared with Terramycin, tetracycline are strong.It is mainly used in treating mycoplasmosis, colibacillosis, the sramana of livestock and poultry Salmonella disease, pasteurellosis and psittacosis.It is for oral administration to absorb rapid, it is smaller by food effect, it is biological Availability is high, and effective blood drug concentration is held time length, strong to tissue infiltration power, widely distributed.

Oral disnitegration tablet can influence the rate of dissolution of medicine, and quick release simultaneously reaches action target spot, soon Speed reaches CSS, extremely important in terms of severe infections are prevented and treated, so as to control acute disease acute Breaking-out and infection, therefore being made oral disnitegration tablet can improve the bioavilability of medicine and can control rapidly Infection.Oral disnitegration tablet need not use water delivery service, and saliva can make it be disintegrated or dissolve, you can by general Obstruction-removing prescription is swallowed, and be can be placed on again and is taken after being disintegrated in water, can also be without to be taken medicine with water swallow.In medicine Thing can rapidly be disintegrated before reaching intestines and stomach and be dispersed into trickle particle, cause medicine in intestines and stomach Large area is distributed, and absorbs point and increases, so as to reduce local excitation of the medicine to intestines and stomach.Due to Oral disnitegration tablet is disintegrated rapidly in mouth, except major part enters parenteral with swallowing act, also has Considerable part direct oral cavity absorbs, thus rapid-action, first pass effect is small, be particularly suited for serious disease, Dysphagia and the livestock and poultry of water intaking inconvenience, for medication is provided conveniently, in the preparation using A Siba The smooth mouthfeel for improving preparation, greatly improves drug compliance, solves the problems, such as that medication is difficult.

Doxycycline hydrochloride oral disintegrating tablet at home and abroad there is no the production of this product, also not there is the product The development of product, thus it is domestic be badly in need of developing a kind of and a series of convenient drug administration, be not required to feed water, Absorb fast, bioavilability high, instructions of taking, in good taste, enteron aisle residual less, side effect it is low, Avoid the first pass effect of liver or only need on a small quantity with water and without the veterinary products of chewing, to make up Blank of the domestic veterinary drug market in formulation, for the acute disease special-purpose medicaments for treating livestock and poultry severe infections are opened Ward off new way.

The content of the invention

Absorb that fast, bioavilability is high the purpose of the present invention is to propose to one kind, enteron aisle residual less, it is secondary Low doxycycline hydrochloride oral disintegrating tablet for domestic fowls of effect and preparation method thereof.

The present invention realizes that the technical scheme of purpose is：

A kind of doxycycline hydrochloride oral disintegrating tablet for domestic fowls, constituent component and its parts by weight are distinguished For：

A kind of preparation method of doxycycline hydrochloride oral disintegrating tablet for domestic fowls, step is：

(1) Doxycycline Hyclate, microcrystalline cellulose, low-substituted hydroxypropyl cellulose, lactose are crossed 80 Mesh sieve is standby；

(2) recipe quantity Doxycycline Hyclate, low-substituted hydroxypropyl cellulose, lactose, A Siba are weighed Smooth, fresh milk king essence, the microcrystalline cellulose each component of recipe quantity 4/5, are progressively increased mode with equivalent, Mix, form mixture of powders；

(3) recipe quantity saccharin sodium is dissolved in ethanol solution, be well mixed standby；

(4) to uniform sprinkling saccharin sodium ethoxide solution in mixture of powders, softwood is made, uses 20 mesh Sieve series grain；

(5) dried 2~3 hours under 55 ± 5 DEG C of temperature conditionss, control granule moisture level is less than 3%；

(6) 20 mesh sieve whole grains are crossed, the microcrystalline cellulose of recipe quantity magnesium stearate and recipe quantity 1/5 is added, Mix；

(7) it is tabletted, obtain final product doxycycline hydrochloride oral disintegrating tablet.

And, the concentration of the ethanol solution is 75%.

The advantages of the present invention are：

(1), in dissolved in oral cavity, uniform in gastrin IR cells, 10% medicine is in Entogastric lingering for the present invention 5.5 hours, enteron aisle residual was few, and side effect is low, and absorption is fast, bioavilability is high, can avoid Hydrochloric acid in gastric juice eroding drug, is conducive to increasing the stability of medicine, and local controlling can be carried out to helicobacter pylori Treat.

(2) production equipment of the present invention is simple, it is easy to operate, and weight differential is small, low cost, breaks The routine of oral disnitegration tablet is only produced with lyophilized technique, is opened domestic using the pelleting of general powder Pressed-disc technique can produce oral disnitegration tablet, be the important breakthrough of domestic oral formulations process technology, For domestic veterinary drug market treatment acute disease opens new way.

(3) doxycycline hydrochloride oral disintegrating tablet involved in the present invention is TCs, can It is widely used in the infectious diseases that treatment Gram-positive, negative bacterium and mycoplasma cause, such as Pasteur Bacillosis, brucellosis, anthrax, colibacillosis, salmonellosis, spirochaeta hyos disease, Mycoplasmosis of pig and chicken etc..

Specific embodiment

Below by specific embodiment, the invention will be further described, and following examples are description Property, it is not limited, it is impossible to which protection scope of the present invention is limited with this.

Embodiment 1：

A kind of doxycycline hydrochloride oral disintegrating tablet for domestic fowls, its constituent component and its parts by weight point (Wei not matched by every 1000 doxycycline hydrochloride oral disintegrating tablet supplementary materials, following examples Together)：

The bulk drug of doxycycline hydrochloride oral disintegrating tablet involved in the present invention is the how western ring of hydrochloric acid Element, its chemical name is：6- methyl -4- (dimethylamino) -3,5,10,12,12a,-penta hydroxy group -1,11- two The ethanol semihydrate of oxo -1,4,4a, 5,5a, 6,11,12a- octahydro -2- aphthacenes carboxamide hydrochloride half.

A kind of preparation method of doxycycline hydrochloride oral disintegrating tablet for domestic fowls, comprises the following steps：

(1) Doxycycline Hyclate, microcrystalline cellulose, low-substituted hydroxypropyl cellulose, lactose are crossed 80 Mesh sieve is standby；

(2) recipe quantity Doxycycline Hyclate, the microcrystalline cellulose of recipe quantity 4/5, low substitution hydroxyl are weighed Propyl cellulose, lactose, aspartame, fresh milk king's essence each component, equivalent are progressively increased, and are mixed；

(3) recipe quantity saccharin sodium is dissolved in 75% ethanol solution, be well mixed standby；

(4) to uniform sprinkling saccharin sodium ethoxide solution in mixture of powders, softwood is made, uses 20 mesh Sieve series grain；

(5) dried 2-3 hours under 55 ± 5 DEG C of temperature conditionss, control granule moisture level is less than 3%；

(6) 20 mesh sieve whole grains are crossed, the microcrystalline cellulose of recipe quantity magnesium stearate and recipe quantity 1/5 is added Element, mixes (measure granule content)；

(7) tabletted (hardness is controlled in 30N or so), obtains final product doxycycline hydrochloride oral disintegration Piece.

Embodiment 2：

A kind of doxycycline hydrochloride oral disintegrating tablet for domestic fowls, its constituent component and its parts by weight point It is not：

The step of the present embodiment preparation method, is same as embodiment 1.

Claims (3)

1. a kind of doxycycline hydrochloride oral disintegrating tablet for domestic fowls, it is characterised in that：Composition group Divide and its parts by weight are respectively：

2. a kind of doxycycline hydrochloride oral disintegrating tablet for domestic fowls as claimed in claim 1 Preparation method, it is characterised in that：The step of preparation method is：

(1) by Doxycycline Hyclate, microcrystalline cellulose, low-substituted hydroxypropyl cellulose, lactose mistake 80 mesh sieves are standby；

(2) recipe quantity Doxycycline Hyclate, low-substituted hydroxypropyl cellulose, lactose, A Si are weighed Batan, fresh milk king essence, the microcrystalline cellulose each component of recipe quantity 4/5, with the equivalent side of progressively increasing Formula, mixes, and forms mixture of powders；

(3) recipe quantity saccharin sodium is dissolved in ethanol solution, be well mixed standby；

(4), to uniform sprinkling saccharin sodium ethoxide solution in mixture of powders, softwood is made, with 20 Mesh sieve is pelletized；

(5) dried 2~3 hours under 55 ± 5 DEG C of temperature conditionss, control granule moisture level is less than 3%；

(6) 20 mesh sieve whole grains are crossed, adds the crystallite of recipe quantity magnesium stearate and recipe quantity 1/5 fine Dimension element, mixes；

(7) it is tabletted, obtain final product doxycycline hydrochloride oral disintegrating tablet.

3. the system of doxycycline hydrochloride oral disintegrating tablet for domestic fowls according to claim 2 Preparation Method, it is characterised in that：The concentration of the ethanol solution is 75%.