CN106913952B - A kind of single gauze medical multifunctional nasal plug and preparation method thereof - Google Patents

Abstract

The invention provides a single yarn medical multifunctional nasal plug and a preparation method thereof. The medical multifunctional nasal plug with single yarn is characterized in that the medical multifunctional nasal plug is formed by knitting one yarn at a time. The invention has high porosity, and the connectivity of the pores reaches 100 percent, thereby having good air permeability. The good elasticity can make the nasal cavity shape of the human body fit well. Good support ensures a stable fixation within the nasal threshold. Excellent water absorption and water retention performance. Easy medicine carrying and can realize local controllable slow release of the medicine. Simultaneously has the functions of imbibition, ventilation and drug delivery. The structure is simple, the forming process is controllable, and automation and standardization are easy to realize. The size, the aperture and the porosity of the nasal plug can be adjusted at will by changing the thickness, the tension, the number of turns and the number of needles of the yarn. The use is beautiful, and the pertinence, the practicability and the popularization are strong.

Description

A kind of single gauze medical multifunctional nasal plug and preparation method thereof

technical field

The invention relates to a single gauze medical multifunctional nasal plug and a preparation method thereof, belonging to the field of medical devices.

Background technique

Rhinitis, sinusitis, cold and other symptoms such as runny nose, nasal congestion, and swelling and pain of nasal mucosa are very common in daily life, which brings a lot of trouble to people's life, study and work. At present, there is no effective method to treat the symptoms of rhinorrhea clinically. It can only be relieved by oral rhinitis medicine, sinusitis medicine or cold medicine. However, the cycle is long, the effect is slow, and the most important thing is that the targeted treatment effect of the medicine is poor. After the drug enters the human body's circulating blood, it not only acts on the nasal cavity inflammation, but also reaches other normal tissues and organs, and there are hidden side effects. Therefore, it is common for patients to stuff their nostrils with cotton balls or toilet paper balls while working. This is not only unsightly, but also affects breathing and poses a safety hazard, and there is a risk of falling cotton fibers entering the respiratory tract. For the relief of nasal congestion and nasal mucosal swelling and pain, drops, sprays, and ventilation nasal stickers can be used to relieve nasal congestion. However, in the form of drops and sprays, the drug is easy to lose, the effect of the drug is short, easy to repeat, and the operation is inconvenient. The ventilation nasal patch is administered through the skin, which has low administration efficiency, long cycle, slow effect, and unsightly use, which also limits its popularization and application.

Therefore, the present invention provides a single gauze medical multifunctional nasal obstruction, which simultaneously has the functions of liquid absorption, ventilation and local controllable sustained release of drugs, and can solve the problems of runny nose, nasal congestion and difficulty in local administration at one time. After searching, there is only one document that is similar to the present invention but has substantial differences, which is a multi-purpose nasal obstruction administered through the nasal cavity (application number: 200510098838.X). The nasal plug is composed of a hollow sphere and a handle clip, and is made of latex, silica gel, plastic, metal or other materials by methods such as perfusion, film attachment, blowing, pressing, injection molding, metal mold pressing and the like. The drug is administered by packing the drug into a hollow sphere. Obviously, compared with the nasal plug described in the present invention, the nasal plug has complex structure and preparation process, single function, unsightly use and low practicability. Thus, it can be seen that the single yarn medical multifunctional nasal plug involved in the present invention is substantially different from the above nasal plug, and has novelty, creativity, practicability and irreplaceability.

SUMMARY OF THE INVENTION

The purpose of the present invention is to provide a single gauze medical multifunctional nasal plug to solve the problem of lack of existing medical devices for relieving the symptoms of runny nose, nasal congestion and swelling and pain of nasal mucosa.

In order to achieve the above purpose, the present invention provides a single-yarn medical multifunctional nasal plug, which is characterized in that only one yarn is knitted and formed once.

Preferably, the yarn is a superabsorbent fiber yarn.

Preferably, the knitting method is short stitch method.

Preferably, the size, pore size and porosity of the medical multifunctional nasal plug can be adjusted arbitrarily by changing at least one of the yarn thickness, tension, number of turns and number of needles.

Preferably, the medical multifunctional nasal plug is a hollow structure.

Preferably, the medical multifunctional nasal plug is an ellipsoid.

Preferably, the connectivity of the holes of the medical multifunctional nasal plug is 100%.

Preferably, the medical multifunctional nasal plug has a single-layer structure.

The present invention also provides a method for preparing a single gauze medical multifunctional nasal plug, which is characterized by comprising the following steps:

The first step: wrap a yarn around a starting loop on the knitting rod, and then use a crochet hook to start m short stitches on the starting loop to form the first loop, where m is an integer greater than or equal to 1;

The second step: from the second circle, the number of short stitches in each circle is increased by one, and n circles are continuously knitted, and n is an integer greater than or equal to 1;

The third step: from the n+1th circle, the number of short stitches in each circle is reduced by one until the end is closed, and the prototype preparation is completed;

Step 4: The prototype is loaded with drugs by dipping method or coating method, and the preparation of single yarn medical multifunctional nasal plug is completed.

Preferably, the m is 3-9.

Preferably, the n is 2-9.

Preferably, the medicine is a clinically used medicine for relieving nasal congestion and swelling and pain of nasal mucosa.

Compared with the prior art, the beneficial effects of the present invention are:

1. The single-yarn medical multifunctional nasal plug provided by the present invention is formed by knitting only one yarn at a time, with a simple structure and no risk of short fiber tow.

2. The single-yarn medical multifunctional nasal plug provided by the present invention has good elasticity and support performance, and can not only fit well with the nasal threshold, but also ensure stable fixation within the nasal threshold.

3. The single-yarn medical multifunctional nasal plug provided by the present invention has high porosity and 100% connectivity of pores, so it has good air permeability.

4. The single-yarn medical multifunctional nasal obstruction provided by the present invention has good water absorption and water retention performance, and can effectively relieve the symptoms of runny nose.

5. The single-yarn medical multifunctional nasal plug provided by the present invention is convenient for drug loading, can realize local controllable sustained release of the drug, and has high administration efficiency, good effect and durability.

6. The single-yarn medical multifunctional nasal plug provided by the present invention can arbitrarily adjust the size, aperture and porosity of the nasal plug by changing the yarn thickness, tension, number of turns and stitches.

7. The single-yarn medical multifunctional nasal plug provided by the present invention has the functions of liquid absorption, ventilation and drug administration at the same time, is beautiful to use, and has strong practicability and pertinence.

8. The method for preparing a single-yarn medical multifunctional nasal plug provided by the present invention is a short needle method, which has a simple process, a short process, less time-consuming, and is easy to automate and standardize.

9. The single-yarn medical multifunctional nasal plug provided by the present invention is easy to carry drugs and can realize local controllable sustained release of drugs.

Description of drawings

Figure 1 is a schematic structural diagram of a single yarn medical multifunctional nasal plug.

Figure 2 is the sustained release diagram of three kinds of single gauze medical multifunctional nasal obstruction drugs. The curve 1 corresponds to the embodiment 1, the curve 2 corresponds to the embodiment 2, and the curve 3 corresponds to the embodiment 3.

Detailed ways

The present invention will be further described below in conjunction with specific embodiments. It should be understood that these examples are only used to illustrate the present invention and not to limit the scope of the present invention. In addition, after reading the content of the present invention, those skilled in the art can make various changes or modifications to the present invention, and these equivalent forms also fall within the scope defined by the appended claims of the present application.

Example 1

As shown in Figure 1, a single-yarn medical multifunctional nasal plug is formed by only one superabsorbent fiber yarn (Technical Absorbents Ltd, No. 2085206) by short stitch knitting. The medical multifunctional nasal plug is a hollow ellipsoid.

The medical multifunctional nasal plug has high porosity, and the connectivity of pores reaches 100%, so it has good air permeability. Good elasticity can make it fit well with the shape of the human nasal threshold. Good support ensures that it can be stably fixed within the nasal threshold. Excellent water absorption and water retention properties. It is easy to carry drugs and can achieve local controllable sustained release of drugs. The structure is simple, the molding process is controllable, and it is easy to realize automation and standardization.

The present invention also provides the preparation method of the above-mentioned medical multifunctional nasal obstruction, the specific steps are:

Step 1: Wrap a superabsorbent fiber yarn around a starting loop on the knitting rod, then crochet 3 short stitches around the starting loop to form the first loop.

Step 2: From the second circle onwards, increase the number of short stitches by one per circle, and knit 3 circles in a row.

Step 3: From the 4th lap, the number of short stitches in each lap is reduced by one until the end is closed, and the prototype preparation is completed.

Step 4: The prototype is loaded with drugs by the immersion method, and the prototype is immersed in a triamcinolone acetonide solution with a concentration of 22 μg/mL for 10 minutes, then taken out to dry, and the preparation of the multifunctional nasal plug is completed.

The obtained multifunctional nasal plug has a maximum radius of 4 mm and a height of 6 mm. It can be used to relieve the symptoms of cold and nasal congestion, with good air permeability and obvious liquid absorption effect.

Example 2

As shown in Figure 1, a single-yarn medical multifunctional nasal plug is formed by only one superabsorbent fiber yarn (Technical Absorbents Ltd, No. 2085208) by short stitch knitting. The medical multifunctional nasal plug is a hollow ellipsoid.

The medical multifunctional nasal plug has high porosity, and the connectivity of pores reaches 100%, so it has good air permeability. Good elasticity can make it fit well with the shape of the human nasal threshold. Good support ensures that it can be stably fixed within the nasal threshold. Excellent water absorption and water retention properties. It is easy to carry drugs and can achieve local controllable sustained release of drugs. The structure is simple, the molding process is controllable, and it is easy to realize automation and standardization.

The present invention also provides the preparation method of the above-mentioned medical multifunctional nasal obstruction, the specific steps are:

Step 1: Wrap a superabsorbent fiber yarn around a starting loop on the knitting rod, then crochet 6 short stitches around the starting loop to form the first loop.

Step 2: From the second circle, increase the number of short stitches by one per circle, and knit 4 circles in a row.

Step 3: From the 5th lap, the number of short stitches in each lap is reduced by one until the stitch is closed, and the prototype preparation is completed.

Step 4: The prototype is loaded with drugs by the dipping method, and the prototype is immersed in a triamcinolone acetonide solution with a concentration of 44 μg/mL for 10 minutes, then taken out to dry, and the preparation of the multifunctional nasal plug is completed.

The obtained multifunctional nasal plug has a maximum radius of 5 mm and a height of 7 mm. It can be used to relieve the symptoms of cold and nasal congestion, with good air permeability and obvious liquid absorption effect.

Example 3

As shown in Figure 1, a single-yarn medical multifunctional nasal plug is formed by only one superabsorbent fiber yarn (Technical Absorbents Ltd, No. 2085210) by short stitch knitting. The medical multifunctional nasal plug is a hollow ellipsoid.

The medical multifunctional nasal plug has high porosity, and the connectivity of pores reaches 100%, so it has good air permeability. Good elasticity can make it fit well with the shape of the human nasal threshold. Good support ensures that it can be stably fixed within the nasal threshold. Excellent water absorption and water retention properties. It is easy to carry drugs and can achieve local controllable sustained release of drugs. The structure is simple, the molding process is controllable, and it is easy to realize automation and standardization.

The present invention also provides the preparation method of the above-mentioned medical multifunctional nasal obstruction, the specific steps are:

Step 1: Wrap a superabsorbent fiber yarn around a starting loop around the knitting rod, then crochet 9 short stitches around the starting loop to form the first loop.

Step 2: From the second circle onwards, increase the number of short stitches by one per circle, and knit 8 circles in a row.

Step 3: From the 9th lap, the number of short stitches in each lap is reduced by one until the stitch is closed, and the prototype preparation is completed.

The fourth step: the prototype is loaded with the drug by the coating method, and the triamcinolone acetonide solution with a concentration of 66 μg/mL is coated on the prototype, dried, and the multifunctional nasal plug is prepared.

The obtained multifunctional nasal plug has a maximum radius of 6 mm and a height of 8 mm. It can be used to relieve the symptoms of cold and nasal congestion, with good air permeability and obvious liquid absorption effect.

The single yarn medical multifunctional nasal plugs of Examples 1-3 were placed in centrifuge tubes filled with 10 mL of PBS solution, and oscillated at a constant temperature at 37 ° C; 1 mL of solution was taken out every 5 min, and the absorbance was measured with an ultraviolet-visible spectrophotometer; The tube was supplemented with 1 mL of PBS solution, and the liquid volume in the centrifuge tube was kept constant; the triamcinolone acetonide concentration and cumulative drug release amount were calculated from the triamcinolone acetonide standard curve equation and plotted, and the results were shown in Figure 2.

Claims (4)

1. A single yarn medical multifunctional nasal plug is characterized in that only one yarn is knitted and formed at one time;

the yarns are super absorbent fiber yarns;

the knitting method of the single yarn medical multifunctional nasal plug is a short needle method;

the single-yarn medical multifunctional nasal plug is prepared by the following steps:

the first step is as follows: winding a yarn on a knitting rod to form a starting ring, and then starting m-needle short needles on the starting ring by using crochet needles to form a first circle, wherein m is an integer of 3-9;

the second step is that: from the second circle, increasing one short needle per circle, continuously weaving n circles, wherein n is an integer of 2-9;

the third step: from the n +1 th circle, the number of short needles in each circle is reduced by one until the needle is closed, and the prototype preparation is completed;

the fourth step: carrying medicine on the prototype by adopting a dipping method or a coating method, and completing the preparation of the single-yarn medical multifunctional nasal plug;

the size, the aperture and the porosity of the single-yarn medical multifunctional nasal plug can be randomly adjusted by changing at least one of the thickness, the tension, the number of turns and the number of needles of the yarn.

2. The single yarn medical multifunctional nasal plug of claim 1, wherein the single yarn medical multifunctional nasal plug is a hollow structure.

3. The single yarn medical multifunctional nasal plug of claim 1, wherein the single yarn medical multifunctional nasal plug is an ellipsoid.

4. The method for preparing the single yarn medical multifunctional nasal plug according to claim 1, wherein the fourth step medicament carrying medicament is a medicament for relieving nasal plug and nasal mucosa swelling and pain in clinical use.

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