CN106860788A - A kind of Chinese medicine preparation for treating canker sore - Google Patents
A kind of Chinese medicine preparation for treating canker sore Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine preparation for treating canker sore, according to mass parts meter, it is made up of following raw material：Coix seed 5-11 parts, dried orange peel 3-7 parts, dandelion 12-20 parts, tribulus terrestris 8-15 parts, teasel root 4-9 parts, Fructus meliae toosendan 8-14 parts, bigleafbeautyberry root or leaf 9-15 parts, root of large-flowered skullcap 6-9 parts, Radix Isatidis 7-12 parts, radish seed 16-25 parts, centella 9-13 parts, sterculia seed 7-12 parts, black nightshade 6-9 parts.Chinese medicine preparation of the present invention has functions that clearing heat and detoxicating, detumescence and apocenosis, invigorating the spleen for eliminating dampness, tonifying spleen and kidney, myogenic treat sore, directly orally enter in vivo, have that short treatment time, instant effect, determined curative effect, cure rate be high, efficient height for the treatment of canker sore, difficulty in relapse after healing, and the characteristics of safe without toxic side effect.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, specifically a kind of Chinese medicine preparation for treating canker sore.
Background technology
Canker sore is a kind of disease of incidence of disease highest in oral keritonocytes, there is the superficial ulcer on oral mucosa, big I is from the grain of rice to soya bean size, circular or oval, ulcer surface is congested for recessed, surrounding, pain can be triggered because of irritable food, general one or two week can be with self-healing.Canker sore inducement is probably local trauma, stress, food, medicine, hormonal readiness change and vitamin or microelement deficiencies.Systemic disease, heredity, immune and microorganism may play an important role in the generation, development of canker sore.
At present, the treatment of canker sore is main based on doctor trained in Western medicine, and doctor trained in Western medicine is treated with taking antiphlogistic, or takes vitaminization, or part is treated with jodine glycerin.Also Chinese herbal medicine is taken to be treated.But said medicine or therapeutic effect are poor, or slowly effect.Fail effectively to alleviate the cusalgia that canker sore is brought during treatment, it is difficult to improve pain to patient in work, life and the influence slept.
The content of the invention
It is an object of the invention to provide a kind for the treatment of time is short, instant effect, cure rate is high, be difficult recurrence and safe without toxic side effect treatment canker sore Chinese medicine preparation.
To achieve the above object, the present invention provides following technical scheme：
A kind of Chinese medicine preparation for treating canker sore, according to mass parts meter, is made up of following raw material：Coix seed 5-11 parts, dried orange peel 3-7 parts, dandelion 12-20 parts, tribulus terrestris 8-15 parts, teasel root 4-9 parts, Fructus meliae toosendan 8-14 parts, bigleafbeautyberry root or leaf 9-15 parts, root of large-flowered skullcap 6-9 parts, Radix Isatidis 7-12 parts, radish seed 16-25 parts, centella 9-13 parts, sterculia seed 7-12 parts, black nightshade 6-9 parts.
As further scheme of the invention：According to mass parts meter, it is made up of following raw material：Coix seed 7-9 parts, dried orange peel 3-6 parts, dandelion 15-18 parts, tribulus terrestris 8-12 parts, teasel root 4-7 parts, Fructus meliae toosendan 9-12 parts, bigleafbeautyberry root or leaf 12-15 parts, root of large-flowered skullcap 6-8 parts, Radix Isatidis 8-10 parts, radish seed 18-22 parts, centella 9-11 parts, sterculia seed 8-11 parts, black nightshade 6-8 parts.
As further scheme of the invention：According to mass parts meter, it is made up of following raw material：8 parts of coix seed, 5 parts of dried orange peel, 16 parts of dandelion, 11 parts of tribulus terrestris, 5 parts of teasel root, 10 parts of Fructus meliae toosendan, 14 parts of bigleafbeautyberry root or leaf, 7 parts of the root of large-flowered skullcap, 9 parts of Radix Isatidis, 20 parts of radish seed, 10 parts of centella, 9 parts of the sterculia seed, 7 parts of black nightshade.
The preparation method of the Chinese medicine preparation of described treatment canker sore, comprises the following steps：By above-mentioned mass parts, each raw material is weighed, mixed, after the 6-8 times of water measured of addition material quality summation soaks 3-5 hours, decocted and extract three times, merge extract solution, filtered, it is paste to concentrate, and through drying, is made capsule.
The usage and dosage of the Chinese medicine preparation of described treatment canker sore is：Twice daily, early, evening is each once, and half an hour warm water takes after meal, each takes the active principle relative to 50g crude drugs.3 days is 1 course for the treatment of, and the 2-5 course for the treatment of can cure.
The property of medicine and effect of medicinal material of the present invention are as follows：
Coix seed, alias Job's tears, the seed of jog's tears, myotonin, ditch rice are the dry mature kernal of grass Job's tears.Cool in nature, sweet, light, returns spleen, stomach, lung channel have functions that invigorating the spleen excreting dampness, remove numbness antidiarrheal, clearing away heat and eliminating pus.For oedema, tinea pedis, difficult urination, arthritis with fixed pain caused by dampness contraction, splenasthenic diarrhea, lung carbuncle, acute appendicitis；Flat wart.
Dried orange peel, alias orange peel is the dry mature skin of rutaceae orange and its variety.It is warm in nature, bitter, pungent, return lung, the spleen channel, with regulating qi-flowing for strengthening spleen, eliminating dampness and eliminating phlegm effect.For chest gastral cavity turgor, deficiency of food is vomited and diarrhoea, coughing with a lot of sputum.
Dandelion, alias dandelion, Po Poding, be feverfew dandelion, alkali ground dandelion or belong to several plants together dry herb.Cold in nature, bitter, sweet, Return liver, stomach have functions that clearing heat and detoxicating, dispersing swelling and dissipating binds, inducing diuresis for treating strangurtia.For furuncle swelling toxin, acute mastitis, scrofula, hot eyes, pharyngalgia, lung carbuncle, acute appendicitis, jaundice with damp-heat pathogen, puckery pain of heat gonorrhea.
Tribulus terrestris, alias thatch, puncture vine, Fructus Tribuli, bypass, drawer people, only row, jackal plumage, liter push away, i.e. lamb's-quarters, tribulus terrestris, Du puncture vine, stop plumage, non-irrigated grass, triangle puncture vine, triangle pierce, anise thorn, puncture frame, open country water caltrop, water chestnut, hard puncture vine, Ji Li Follicle radish, be the fruit of zygophyllaceae plant puncture vine.Warm in nature, bitter, pungent, Return liver, lung channel have functions that scattered wind, improving eyesight, lower gas, promoting circulation of blood.Headache is controlled, body is itched, hot eyes swells screen, fullness sensation in chest, cough inverse, abdominal mass, breast is difficult, ulcer, scrofula.
Teasel root, alias teasel, shaven head, chervil are the dry root of Dipsacaceae plant teasel.Slightly warm in nature, it is bitter, pungent, return liver and kidney channel, there is filling liver kidney, strengthening the bones and muscles, continuous injured, only uterine bleeding.For soreness and weakness of waist and knees, arthralgia pain due to rheumatism, uterine bleeding, threatened abortion, injury from falling down.Prepared RADIX DIPSACI with yellow rice wine is used for arthralgia pain due to rheumatism, injury from falling down.Prepared RADIX DIPSACI with salt solution is used for soreness and weakness of waist and knees.
Fructus meliae toosendan, alias FRUCTUS TOOSENDAN, melia toosendan reality are the dry mature fruit of Meliaceae plant melia toosendan.Cold in nature, bitter is slightly poisonous, Return liver, small intestine, bladder warp, has functions that easypro liver promoting qi circulation and relieving pain, expelling parasite.For chest side of body, abdominal distention, colic, abdominal pain due to enterositosis.
Bigleafbeautyberry root or leaf, alias Japanses beauty-berry grass, big blade, catch up with wind it is purple, it is red say greatly, vacation great Ai, be Verbena officinalis Japanses beauty-berry platymiscium bigleafbeautyberry root or leaf, be used as medicine with root and leaf.Mild-natured, taste is pungent, hardship have functions that dissipate stasis of blood hemostasis, swelling and pain relieving.Leaf：For spitting blood, spitting of blood, bleeding from five sense organs or subcutaneous tissue is had blood in stool；External curing traumatism and bleeding.Root：Treating swelling and pain by traumatic injury, treating rheumatic ostealgia.
The root of large-flowered skullcap, alias Radix Scutellariae, scutellaria tea, tsuchikane tea root are the dry root of the labiate root of large-flowered skullcap.It is cold in nature, bitter, return lung, courage, spleen, large intestine, small intestinl channel, with heat-clearing and damp-drying drug, purging intense heat and detonicating, hemostasis, antiabortive effect.For damp-warm syndrome, heat temperature evil of vomitting uncomfortable in chest, damp and hot feeling of fullness, rush down dysentery, jaundice, cough with lung heat, hyperpyrexia polydipsia, blood-head tells nosebleed, carbuncle sore tumefacting virus, fetal irritability.
Radix Isatidis, alias great Lan roots, manyflower glorybower root are the dry root of cruciferae isatis.It is cold in nature, bitter, the thoughts of returning home, stomach have functions that clearing heat and detoxicating, cool blood relieving sore-throat.For febrile virulent maculae, tongue is dark reddish purple dark, mumps, larynx numbness, scarlet fever, major part pestilence, erysipelas, carbuncle swells.
Radish seed, alias SEMEN RAPHANI is the dry mature seed of crucifer radish.Mild-natured, taste is pungent, sweet, return lung, spleen, stomach have functions that help digestion de-swelling, lowering the adverse-rising QI to resolve phlegm.For retention of food and drink, abdominal distention, constipation, stagnant rush down dysentery, phlegm heap soil or fertilizer over and around the roots is breathed with cough.
Centella, alias collapse jorum, membranaceous marshmarigold herb, Gotu Kola, blood clam shell grass, copper coin grass, centella asiatica, and is that samphire centella dries herb.Cold in nature, bitter, pungent, Return liver, spleen, kidney channel have functions that clearing heat and promoting diuresis, removing toxicity for detumescence.For jaundice with damp-heat pathogen, heatstroke diarrhoea, sand drenches blood strangury, carbuncle sore tumefacting virus, injury from falling down.
The sterculia seed, alias sea, SEMEN STERCULIAE LYCHNOPHORAE, great Dong Guo, big hair, are the dry mature seed of the Sterculiaceae plant sterculia seed.Cold in nature, sweet, return lung, large intestine channel have functions that clearing heat and moistening lung, liyan jiedu, relax bowel.For lung heat celostomia, dry cough without phlegm, pharyngodynia with dryness, thermojunction is just closed, hot eyes of having a headache.
Black nightshade, alias black nightshade grass, Soda-apple Night-shade Herb, night day, bitter certain herbaceous plants with big flowers, wild Fructus Capsici, black eggplant, bryony, are Solanaceae nightshade black nightshade, with all herbal medicine.Cold in nature, bitter is slightly poisonous, has functions that clearing heat and detoxicating, inducing diuresis for removing edema.For cat fever, toothache, chronic bronchitis, dysentery, urinary infection, mastitis, leukorrhea, cancer；Carbuncle furuncle furunculosis, pemphigus, snake bite are controlled in external application.
Compared with prior art, the beneficial effects of the invention are as follows：Chinese medicine preparation of the present invention has functions that clearing heat and detoxicating, detumescence and apocenosis, invigorating the spleen for eliminating dampness, tonifying spleen and kidney, myogenic treat sore, directly orally enter in vivo, have that short treatment time, instant effect, determined curative effect, cure rate be high, efficient height for the treatment of canker sore, difficulty in relapse after healing, and the characteristics of safe without toxic side effect.
Specific embodiment
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described, it is clear that described embodiment is only a part of embodiment of the invention, rather than whole embodiments.Based on the embodiment in the present invention, the every other embodiment that those of ordinary skill in the art are obtained under the premise of creative work is not made belongs to the scope of protection of the invention.
Embodiment 1
It is a kind of in the embodiment of the present invention, according to mass parts meter, it is made up of following raw material：5 parts of coix seed, 7 parts of dried orange peel, 12 parts of dandelion, 15 parts of tribulus terrestris, 4 parts of teasel root, 14 parts of Fructus meliae toosendan, 9 parts of bigleafbeautyberry root or leaf, 9 parts of the root of large-flowered skullcap, 7 parts of Radix Isatidis, 25 parts of radish seed, 9 parts of centella, 12 parts of the sterculia seed, 6 parts of black nightshade.
The preparation method of the Chinese medicine preparation of described treatment canker sore, comprises the following steps：By above-mentioned mass parts, each raw material is weighed, mixed, after adding 8 times of water measured of material quality summation to soak 4 hours, decocted and extract three times, merge extract solution, filtered, it is paste to concentrate, and through drying, is made capsule.
Embodiment 2
In the embodiment of the present invention, a kind of Chinese medicine preparation for treating canker sore, according to mass parts meter, is made up of following raw material：11 parts of coix seed, 3 parts of dried orange peel, 20 parts of dandelion, 8 parts of tribulus terrestris, 9 parts of teasel root, 8 parts of Fructus meliae toosendan, 15 parts of bigleafbeautyberry root or leaf, 6 parts of the root of large-flowered skullcap, 12 parts of Radix Isatidis, 16 parts of radish seed, 13 parts of centella, 7 parts of the sterculia seed, 9 parts of black nightshade.
The preparation method of the Chinese medicine preparation of described treatment canker sore is same as Example 1.
Embodiment 3
In the embodiment of the present invention, a kind of Chinese medicine preparation for treating canker sore, according to mass parts meter, is made up of following raw material：7 parts of coix seed, 6 parts of dried orange peel, 15 parts of dandelion, 12 parts of tribulus terrestris, 4 parts of teasel root, 12 parts of Fructus meliae toosendan, 12 parts of bigleafbeautyberry root or leaf, 8 parts of the root of large-flowered skullcap, 8 parts of Radix Isatidis, 22 parts of radish seed, 9 parts of centella, 11 parts of the sterculia seed, 6 parts of black nightshade.
The preparation method of the Chinese medicine preparation of described treatment canker sore is same as Example 1.
Embodiment 4
In the embodiment of the present invention, a kind of Chinese medicine preparation for treating canker sore, according to mass parts meter, is made up of following raw material：9 parts of coix seed, 3 parts of dried orange peel, 18 parts of dandelion, 8 parts of tribulus terrestris, 7 parts of teasel root, 9 parts of Fructus meliae toosendan, 15 parts of bigleafbeautyberry root or leaf, 6 parts of the root of large-flowered skullcap, 10 parts of Radix Isatidis, 18 parts of radish seed, 11 parts of centella, 8 parts of the sterculia seed, 8 parts of black nightshade.
The preparation method of the Chinese medicine preparation of described treatment canker sore is same as Example 1.
Embodiment 5
In the embodiment of the present invention, a kind of Chinese medicine preparation for treating canker sore, according to mass parts meter, is made up of following raw material：8 parts of coix seed, 5 parts of dried orange peel, 16 parts of dandelion, 11 parts of tribulus terrestris, 5 parts of teasel root, 10 parts of Fructus meliae toosendan, 14 parts of bigleafbeautyberry root or leaf, 7 parts of the root of large-flowered skullcap, 9 parts of Radix Isatidis, 20 parts of radish seed, 10 parts of centella, 9 parts of the sterculia seed, 7 parts of black nightshade.
The preparation method of the Chinese medicine preparation of described treatment canker sore is same as Example 1.
Animal acute toxicity test
Animal acute toxicity test now is carried out to Chinese medicine preparation of the present invention, mouse and rat half and half is taken, is divided into five groups, the Chinese medicine preparation/kg prepared equivalent to the embodiment 1~5 of 25g crude drug amounts is orally given respectively（More than 20 times of the dosage behaviour taking dose）, once a day, continue 7 days.To observation post administration 2 weeks, there is no mouse and rats death, show that the toxicity of Chinese medicine preparation of the present invention is little.Therefore, clinical test is carried out to the patient for being diagnosed as canker sore.
Clinical test
1st, physical data
Choose canker sore Patients with 300 Cases, wherein male 152, women 148, age 18-65 Sui, average age 32 years old, the course of disease -10 years 2 months, average course of disease 2.4 years.300 patients are randomly divided into totally six groups, every group 50 for the treatment of 1-5 groups and control group.Each group sex, age and course of disease comparing difference are not statistically significant, with comparativity.
Diagnostic criteria
According to the diagnostic criteria of national recurrent oral ulceration clinical speciality meeting：
（1）Ulcer is rounded or ellipse, size, number, is dispersed in distribution, and neat in edge around has blush, feels pain, there is self limiting and recurrent history, more after do not stay scar.
（2）Ulcer is small and number can up to more than 20, distributed more widely general, and without cluster and fusion phenomenon, patient has pain and with headache, the constitutional symptom such as low-heat, more after do not stay scar.
（3）Be apt to occur in lip inner side and bicker area mucous membrane, the how single generation of ulcer, and big and deep, in " crater " shape, marginal swell, bottom is uneven micro- hard, and the course of disease is long, more after can leave scar.
2nd, treatment method
Capsule obtained in the oral embodiment of the present invention 1-5 for the treatment of 1-5 group difference, twice daily, early, evening is each once, and half an hour warm water takes after meal, each takes the active principle relative to 50g crude drugs.3 days is 1 course for the treatment of, and the 2-5 course for the treatment of can cure.
The oral prednisone of control group（By specification is taken）.10 days courses for the treatment of.
3rd, curative effect determinate standard
Recovery from illness：Pain disappears, ulcer all healed；
It is effective：Pain substantially mitigates, and ulcer area reduces more than 50%；
Effectively：Pain relief, ulcer area is reduced and is less than 50%；
It is invalid：Pain has no mitigation, and ulcer has no and significantly reduces.
4th, treatment results
The comparitive study of each group of table 1
| Project | Case load | Cure number | Effective number | Significant figure | Invalid number | Cure rate | Total effective rate |
| Treat 1 group | 50 | 37 | 6 | 5 | 2 | 74% | 96% |
| Treat 2 groups | 50 | 38 | 6 | 4 | 2 | 76% | 96% |
| Treat 3 groups | 50 | 40 | 5 | 4 | 1 | 80% | 98% |
| Treat 4 groups | 50 | 40 | 6 | 3 | 1 | 80% | 98% |
| Treat 5 groups | 50 | 41 | 5 | 3 | 1 | 82% | 98% |
| Control group | 50 | 32 | 10 | 5 | 3 | 64% | 94% |
By the 2-5 treatment of the course for the treatment of, the curative effect of each group is as shown in table 1：The cure rate of control group is 64%, and total effective rate is 94%；The cure rate for the treatment of group is 74-82%, and total effective rate is up to 96-98%；There is not bad side reaction in patient in therapeutic process.Contrast understands that Chinese medicine preparation of the present invention can safely and effectively treat canker sore, with promotional value.
5th, model case
Case 1：Zhao, female 52 years old, suffers from canker sore more than 2 years, recurrent exerbation, when it is light when weight, multi-treatment be unsatisfied with.Respectively there are 1 ulcer, such as mung bean size in visible gums and tongue side during examining, and intermediate recess covers tunica albuginea, and surrounding protuberance, color is light red, feels aphtha mild pain, there is burning heat sensation, and dryness of the mouth and throat, feverishness in palms and soles, soreness and weakness of waist and knees, spontaneous perspiration, urine is yellow, and stool is dry.Red tongue with a little fluid, the thin Huang of tongue, arteries and veins is carefully slightly counted.Take the Chinese medicine preparation of the embodiment of the present invention 5 ulcer healing after five days, pain disappears recovery from illness, follow-up half a year does not recur.
Case 2：Bai, man 22 years old, there is an about diameter 3mm aphtha at the gum of lower-left in lip, surrounding is congested, centre whiting, and more than 3 days duration, cusalgia substantially, hinder by feed.Cusalgia has slowed down after taking Chinese medicine preparation half a day of the embodiment of the present invention 5.Take two days later, cusalgia is significantly alleviated, congested and whiting position has been desalinated.After taking three days, cusalgia disappears substantially, and congested and whiting position is not obvious.4th day, symptom all disappeared, recovery from illness.Follow-up half a year does not recur.
Case 3：Shi, man, 62 years old, recurrent oral ulceration 4 years was apt to occur in lingual margin, lower lips, cusalgia, and in cratering, edge is without blush.Take the Chinese medicine preparation of the embodiment of the present invention 5 after five days ulcer be obviously reduced, pain substantially mitigates, continual cure five days, and clinical symptoms all disappear recovery from illness, and follow-up half a year does not recur.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, and without departing from the spirit or essential characteristics of the present invention, can in other specific forms realize the present invention.Therefore, no matter from the point of view of which point, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the present invention is limited by appended claims rather than described above, it is intended that all changes fallen in the implication and scope of the equivalency of claim are included in the present invention.
In addition, it should be understood that, although the present specification is described in terms of embodiments, but not each implementation method only includes an independent technical scheme, this narrating mode of specification is only for clarity, those skilled in the art should using specification an as entirety, technical scheme in each embodiment can also through appropriately combined, formed it will be appreciated by those skilled in the art that other embodiment.
Claims (3)
1. a kind of Chinese medicine preparation for treating canker sore, it is characterised in that according to mass parts meter, be made up of following raw material：Coix seed 5-11 parts, dried orange peel 3-7 parts, dandelion 12-20 parts, tribulus terrestris 8-15 parts, teasel root 4-9 parts, Fructus meliae toosendan 8-14 parts, bigleafbeautyberry root or leaf 9-15 parts, root of large-flowered skullcap 6-9 parts, Radix Isatidis 7-12 parts, radish seed 16-25 parts, centella 9-13 parts, sterculia seed 7-12 parts, black nightshade 6-9 parts.
2. it is according to claim 1 treatment canker sore Chinese medicine preparation, it is characterised in that according to mass parts meter, be made up of following raw material：Coix seed 7-9 parts, dried orange peel 3-6 parts, dandelion 15-18 parts, tribulus terrestris 8-12 parts, teasel root 4-7 parts, Fructus meliae toosendan 9-12 parts, bigleafbeautyberry root or leaf 12-15 parts, root of large-flowered skullcap 6-8 parts, Radix Isatidis 8-10 parts, radish seed 18-22 parts, centella 9-11 parts, sterculia seed 8-11 parts, black nightshade 6-8 parts.
3. it is according to claim 1 treatment canker sore Chinese medicine preparation, it is characterised in that according to mass parts meter, be made up of following raw material：8 parts of coix seed, 5 parts of dried orange peel, 16 parts of dandelion, 11 parts of tribulus terrestris, 5 parts of teasel root, 10 parts of Fructus meliae toosendan, 14 parts of bigleafbeautyberry root or leaf, 7 parts of the root of large-flowered skullcap, 9 parts of Radix Isatidis, 20 parts of radish seed, 10 parts of centella, 9 parts of the sterculia seed, 7 parts of black nightshade.
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| CN201510910086.6A CN106860788A (en) | 2015-12-10 | 2015-12-10 | A kind of Chinese medicine preparation for treating canker sore |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7279151B2 (en) * | 2003-12-30 | 2007-10-09 | Council Of Scientific And Industrial Research | Herbal oro-dental care composition and process for preparing the same |
| CN104997990A (en) * | 2015-08-10 | 2015-10-28 | 孙霞 | Traditional Chinese medicine for treating recurrent oral ulceration |
| CN105056065A (en) * | 2015-08-12 | 2015-11-18 | 彭刘平 | Traditional Chinese medicine composition for treating sphagitis |
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2015
- 2015-12-10 CN CN201510910086.6A patent/CN106860788A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7279151B2 (en) * | 2003-12-30 | 2007-10-09 | Council Of Scientific And Industrial Research | Herbal oro-dental care composition and process for preparing the same |
| CN104997990A (en) * | 2015-08-10 | 2015-10-28 | 孙霞 | Traditional Chinese medicine for treating recurrent oral ulceration |
| CN105056065A (en) * | 2015-08-12 | 2015-11-18 | 彭刘平 | Traditional Chinese medicine composition for treating sphagitis |
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| 刘丰: "溃疡汤治疗复发性口腔溃疡60例临床观察", 《甘肃中医》 * |
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Application publication date: 20170620 |