CN106818734A - Microcapsule formulation and its preparation, micro-capsule suspension - Google Patents
Microcapsule formulation and its preparation, micro-capsule suspension Download PDFInfo
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- CN106818734A CN106818734A CN201710013840.5A CN201710013840A CN106818734A CN 106818734 A CN106818734 A CN 106818734A CN 201710013840 A CN201710013840 A CN 201710013840A CN 106818734 A CN106818734 A CN 106818734A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/26—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests in coated particulate form
- A01N25/28—Microcapsules or nanocapsules
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
- A01N47/24—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing the groups, or; Thio analogues thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N53/00—Biocides, pest repellants or attractants, or plant growth regulators containing cyclopropane carboxylic acids or derivatives thereof
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Abstract
The invention provides a kind of microcapsule formulation and its preparation, micro-capsule suspension.Microcapsule formulation of the present invention includes microcapsule shell and the pesticide activity component being encapsulated in the microcapsule shell body, and the pesticide activity component includes pyraclostrobin, AVM and gamma cyhalothrin.Microcapsules of the present invention enable that three's pesticide activity component effectively plays synergistic effect, with consistent release property and lasting effect, give full play to synergistic function, destruction of the undesirable element to three's pesticide activity component is intercepted, improve microcapsule formulation and the stability containing the microcapsule formulation medicament storage, delay degradation speed, and then improve bioavailability, improve prevention effect.Its preparation technology is easily-controllable, and the stabilization of the microcapsule formulation performance for preparing has been effectively ensured.Micro-capsule suspension of the present invention contains microcapsule formulation of the present invention.
Description
Technical field
The invention belongs to field of pesticide preparation, and in particular to a kind of microcapsule formulation and its preparation, micro-capsule suspension.
Background technology
Pyraclostrobin belongs to methoxy acrylic bactericide, is mitochondrial respiratory inhibitor, acts on mitochondria
Inner membrance, by synthesizing in cytochromes in prevent the transfer of electro transfer failure energy, with protection, treatment, blade infiltration conduction
Effect.Pyraclostrobin is wide-spectrum bactericide, is registered on more than 100 crops for controlling at least 49 kinds diseases, is related to fungi
The main pathogen of all 4 big subphylums in classification.
AVM is the ten hexa-atomic Macrocyclic lactone compounds that a class has desinsection, mite killing, eelworm-killing activity, is a kind of work
For insect neuron cynapse or the nerve toxicant of neuromuscular synapse, based on stomach poison function, tag with systemic action compared with
It is small, insect paralysis, food refusal, death are made by block nerves impulse conduction.There is AVM good layer shifting to act on, and penetrate into
AVM in crop leaf tissue can form anther sac in epidermis parenchymal tissue and long term storage plays insecticidal action.AVM hereinafter
Rhzomorph can be used in the preventing and treating of agricultural pests and livestock parasite, and Acarina, coleoptera, same is used on agricultural insect pests control
The preventing and treating of the various pests such as wing mesh, Diptera and Lepidoptera, evil mite.AVM has bioactivity higher, but in water
Can rapidly by photodissociation (half-life period<0.5d), combined closely with organic matter in soil and be difficult to migrate, in actual applications AVM hereinafter
The bioavailability of rhzomorph is low, it is impossible to give full play to the prevention effect of product.
Gamma cyhalothrin belongs to pyrethroid Insecticidal and acaricidal agent, with tag with stomach poison function based on, without interior suction
Effect, by suppressing the conduction at insect neural axon position, has the effect walked quickly and kept away, knock down and kill to insect.Efficient chlorine fluorine
Cyano chrysanthemate is widely used in preventing and treating agricultural pests and public health insect, various to Lepidoptera, coleoptera, Semiptera and Acarina etc.
Insect, evil mite have good prevention effect.But gamma cyhalothrin easily causes human body skin allergy, have impact on product
Produce and use.
Various disease pests are controlled for simultaneous in actual applications, spraying times are reduced, it is general to be mixed using bucket or add Multiple Pesticides
Work is used as complex preparation.But, the degradation rate due to the physical and chemical stability of different agricultural chemicals and in natural environment is different,
Each pesticide composition being used in mixed way can not give full play to compounding effect.There is following defect in specific manifestation：
(1) generally used with barrel mixed form in actual use to reduce recruitment cost pesticidal preparations product, conventional pesticide
Preparation, such as missible oil, microemulsion, aqueous emulsion, the suspending agent formulations of pesticide, pesticide activity thing are easy to be influenceed and quilt by undesirable element
Destruction is decomposed, bucket mixes the additive compatibility that different product when using used and has differences, occur flocculation, particle diameter after bucket is mixed and increase
Greatly, the phenomenon such as demulsification, reduces prevention effect.
(2) prior art is typically for the pesticide activity component of single component to be prepared into microcapsules, then again with contain it
The preparation formulation of his pesticide activity component is mixed and is made complex preparation, such as microcapsule suspension-suspendinagent agent, microcapsule suspension-water
The formulations such as emulsion, microcapsule suspension-oil suspending agent, microcapsule suspension-emulsion, not only work in-process Recipe is complicated, and only part
Agricultural chemicals is encapsulated in microcapsules, and remaining agricultural chemicals exists for the form of suspending agent, aqueous emulsion, oil suspending agent or missible oil, not encapsulated
Agricultural chemicals is easy to be influenceed and the destruction that is decomposed by undesirable element, have impact on three kinds of synergistic functions of agricultural chemicals, and preventive effect is poor.
(3) Multiple Pesticides active component is prepared into microcapsules and then is compounded again respectively and obtain Microcapsules of Pesticides together
Mixture, but Multiple Pesticides active matter separating by cyst wall physics, the size of each microcapsules, the composition of intracapsular material
Point and its ratio, microcapsule wall material composition and thickness, porosity etc. have differences, it is impossible to ensure that three kinds of active components have
Consistent release property and lasting effect, it is impossible to give full play to synergistic function.
The content of the invention
It is an object of the present invention to provide a kind of microcapsule formulation and its preparation and micro-capsule suspension, existing to overcome
There is the phenomenons such as flocculation, particle diameter increase, demulsification during the mixed use of pesticide barrel or single Microcapsules of Pesticides is carried out into mixing and deposit
Respective release property and lasting effect it is inconsistent and cause the undesirable technical problem of synergistic function.
In order to realize foregoing invention purpose, one aspect of the present invention, there is provided a kind of microcapsule formulation.The microcapsule formulation
Including microcapsule shell and the pesticide activity component being encapsulated in the microcapsule shell body；The pesticide activity component includes pyrrole
Azoles kresoxim-methyl, AVM and gamma cyhalothrin.
A kind of another aspect of the present invention, there is provided preparation method of microcapsule formulation, comprises the following steps：
After pyraclostrobin active compound, the former medicine of AVM and gamma cyhalothrin active compound are dissolved in into organic solvent, add
Oil-soluble cyst material carries out mixing treatment, is configured to oil phase；
Emulsifying dispersant is soluble in water, it is configured to water phase；
By the water phase and the blended shear treatment of the oil phase, O/W emulsions are formed；
Interface polymerization reaction is carried out to water-soluble cyst material is added in the O/W emulsions.
A kind of another aspect of the invention, there is provided micro-capsule suspension.The micro-capsule suspension is carried including aaerosol solution
Body and the microcapsules being suspended in the aaerosol solution carrier；The microcapsules are microcapsule formulation of the present invention or are made by the present invention
Microcapsule formulation prepared by Preparation Method.
Compared with prior art, microcapsules of the present invention are by three kinds of pyraclostrobin, AVM and gamma cyhalothrin
Pesticide activity component is encapsulated in same microcapsules, on the one hand enables that three's pesticide activity component effectively plays synergy and makees
With improving its prevention effect；Another aspect three's pesticide activity component is encapsulated in same microcapsules, so that three
Pesticide activity component has consistent release property and lasting effect, gives full play to synergistic function；The third aspect is effectively intercepted
Destruction of the undesirable element to three's pesticide activity component, improves microcapsule formulation and contains the microcapsule formulation medicament storage
Stability, has delayed degradation speed, and then improves bioavailability, improves prevention effect.
Microcapsule formulation preparation method of the present invention is by pyraclostrobin, three kinds of agricultural chemicals of AVM and gamma cyhalothrin
Active component is configured to oil phase with oil-soluble cyst material so that three's pesticide activity is mixed into mutual, when emulsion and water-soluble cyst wall
After material mixing so that oil-soluble cyst material carries out interface polymerization reaction generation microcapsules with water-soluble cyst material, and will
Three's pesticide activity into encapsulating wherein so that three's pesticide activity component gives full play to synergistic function, and with one
The release property and lasting effect of cause, while effectively having intercepted destruction of the undesirable element to three's pesticide activity component, improve micro- glue
Capsule preparation and containing the microcapsule formulation medicament storage stability, has delayed degradation speed, and then improves bioavailability,
Improve prevention effect.In addition, its preparation technology is easily-controllable, the microcapsules average grain diameter of preparation is small and uniform, and system has been effectively ensured
The stabilization of standby microcapsule formulation performance, and production efficiency is effectively increased, reduce production cost.
Micro-capsule suspension of the present invention with the present invention due to containing pyraclostrobin, AVM and gamma cyhalothrin
The microcapsules of three's pesticide activity component are that dispersed phase forms suspending agent, so that the agriculture contained by micro-capsule suspension of the present invention
Medicine active component gives full play to synergistic function, and with consistent release property and lasting effect, while effectively having intercepted bad
Destruction of the factor to three's pesticide activity component, improves micro-capsule suspension storage stability, has delayed degradation speed, and then
Improve bioavailability, improve prevention effect, such as have desinsection, sterilization, mite killing and nematocidal effect concurrently, can be used for paddy rice,
Corn, the seed Dressing of potatoes and other crops or growth period root irrigation prevent and treat the disease pest at underground position.
Specific embodiment
In order that the technical problem to be solved in the present invention, technical scheme and beneficial effect become more apparent, below in conjunction with
Embodiment, the present invention will be described in further detail.It should be appreciated that specific embodiment described herein is only used to explain
The present invention, is not intended to limit the present invention.
The mass ratio or mass percent of embodiment of the present invention each component noted in the disclosure can not only refer to
For the proportionate relationship of quality between each component, it is also possible to represent the concrete content of each component.Therefore, as long as implementing according to the present invention
Example specification composition each component content scale up or reduce embodiment of the present invention specification scope of disclosure it
It is interior.Specifically, the quality described in embodiment of the present invention specification can be known to the pesticidal chemical such as μ g, mg, g, kg field
Mass unit.
On the one hand, the embodiment of the present invention provides a kind of microcapsule formulation.The microcapsule formulation include microcapsule shell and
It is encapsulated in the pesticide activity component in the microcapsule shell body.
Wherein, the microcapsule shell structure of above-mentioned microcapsule formulation can be the microcapsule shell routine of existing microcapsules
Structure.Its thickness and material can also be conventional microcapsule shell body thicknesses.In one embodiment, the microcapsule shell can be as
Hereafter the oil-soluble cyst material in microcapsule formulation preparation method carries out interface polymerization reaction and is formed with water-soluble cyst material.
The above-mentioned pesticide activity component being encapsulated in the microcapsule shell body includes pyraclostrobin, AVM and height
Effect lambda-cyhalothrin three's compound.So, while three kinds of pyraclostrobin, AVM and gamma cyhalothrin are combined
Pesticide activity component is encapsulated in same microcapsules so that three's pesticide activity component can effectively play synergistic effect, and make
Obtaining three's pesticide activity component has consistent release property and lasting effect, while effectively intercepted undesirable element being lived to three's agricultural chemicals
Property composition destruction, improve microcapsule formulation and containing the microcapsule formulation medicament storage stability, delayed degraded speed
Degree, and then bioavailability is improve, improve prevention effect.
In one embodiment, pyraclostrobin, AVM and gamma cyhalothrin contained by above-mentioned microcapsule formulation
Mass ratio is 1: (0.4-10.0): (0.7-30.0).By controlling the mass ratio of three's pesticide activity component, so as to improve three
Synergistic function between person.In further embodiment, the pesticide activity component being encapsulated in microcapsule shell body is dissolved in
In organic solvent, and it is (3.1-41.9) with the mass ratio of the pyraclostrobin to control the organic solvent: 1.So cause
Pesticide activity component dissolves in organic solvent, it is ensured that the scattered uniformity of pesticide activity component and stability, so that further
Improve the synergistic effect between three's pesticide activity component.
On the basis of the various embodiments described above, in one embodiment, above-mentioned pesticide activity component pyraclostrobin can be
The mixture of the arbitrary proportion of single crystal form pyraclostrobin or various crystal formation pyraclostrobins, it is also possible to by Fluoxastrobin, ether bacterium
It is any in the methoxy acrylic bactericides such as ester, kresoxim-methyl, fluorine nalidixic bacterium ester, dirty bacterium ester, ZEN 90160, azoles oxygen bacterium ester
One kind is substituted.
In another embodiment, above-mentioned pesticide activity component gamma cyhalothrin can be the chlorine fluorine cyanogen chrysanthemum of single configuration
Ester or the 2-4 mixture of the arbitrary proportion of the lambda-cyhalothrin of configuration, it is also possible to by Fenpropathrin, decis, cyfluthrin
Any one institute in the pyrethroid insecticideses such as chrysanthemum ester, ethofenprox, cypermethrin, effective cypermethrin, Biphenthrin
Substitute.
In another embodiment, above-mentioned pesticide activity component AVM can be Avermectin B1a, avermectin B2a
The mixture, or ivermectin or emaricin of the arbitrary proportion of isomers or 2-8 kind AVM isomers.
In another embodiment, the organic solvent is from being capable of the organic molten of active solvent three's pesticide activity component
Liquid, preferably selection can dissolve three's pesticide activity component can also be conducive to playing the bioactivity of three pesticide activity component
Organic solvent, the mixed solvent being such as combined from aromatic hydrocarbon solvent and acetates solvent, wherein, the aromatic hydrocarbon solvent and institute
The mass ratio for stating acetates solvent is (5.4-11.4): 1.In a particular embodiment, the aromatic hydrocarbon solvent can be, but not limited to
At least one in trimethylbenzene, S-100, S-150, S-200, toluene, dimethylbenzene, biphenyl；The acetates solvent can be with
But at least one, or fatty acid amide, fatty alcohol being not limited in isobutyl acetate, sec-Butyl Acetate or acetic acid osmanthus ester
In at least one；Fatty acid amide can contain 4 to 10 fatty acid amides of carbon atom；Fatty alcohol can contain 4
To 10 fatty alcohols of carbon atom.
On the basis of the various embodiments described above, the average grain diameter for controlling microcapsule formulation is 0.5 μm~12 μm.The particle diameter model
Enclose the suspending agent that can be effectively configured to stabilization.
In addition, the structure based on above-mentioned microcapsule formulation, is not limited only to said structure, as long as according to above-mentioned micro-
The encapsulating principle of capsule preparations is extended in embodiment of the present invention scope of disclosure, such as microcapsule shell encapsulate other two
Kind or two or more etc. pesticide activity components in embodiment of the present invention scope of disclosure.
Therefore, in the various embodiments described above microcapsule formulation simultaneously by pyraclostrobin, AVM and efficient cyhalothrin
Three kinds of composite pesticide active components of ester are encapsulated in same microcapsules so that synergy is effectively played between three's pesticide activity component
Effect and has intercepted destruction of the undesirable element to three's pesticide activity component with consistent release property and lasting effect, improves
Microcapsule formulation and containing the microcapsule formulation medicament storage stability, has delayed degradation speed, and then improve biology
Utilization rate, improves prevention effect, overcomes existing bucket and mixes the deficiency that single Microcapsules of Pesticides is present.
In addition, microcapsule formulation mentioned above can exist with powderous preparations form, it is also possible to be attached on graininess load
Granule form on body is present, and can be mixed into micro-capsule suspension emulsion with other creamy formulations, can also be with other aqueous suspensions
Preparation is mixed into microcapsule suspension-suspendinagent agent etc..
Correspondingly, the embodiment of the present invention additionally provides a kind of preparation method of microcapsule formulation above.In one embodiment,
The preparation method of embodiment of the present invention microcapsule formulation comprises the following steps：
Step S01：Pyraclostrobin active compound, the former medicine of AVM and gamma cyhalothrin active compound are dissolved in organic solvent
Afterwards, adding oil-soluble cyst material carries out mixing treatment, is configured to oil phase；
Step S02：Emulsifying dispersant is soluble in water, it is configured to water phase；
Step S03：By the water phase and the blended shear treatment of the oil phase, O/W emulsions are formed；
Step S04：Interface polymerization reaction is carried out to water-soluble cyst material is added in the O/W emulsions.
Specifically, as one embodiment of the invention, pyraclostrobin active compound, the former medicine of AVM in above-mentioned steps S01
With the mass ratio 1 of the consumption of folding hundred of the active matter of gamma cyhalothrin active compound：(0.4-10.0)：(0.7-30.0), improves three
Person's synergistic effect.
In one embodiment, the organic solvent in step S01 is with the consumption mass ratio of the pyraclostrobin
(3.1-41.9)∶1.By controlling the consumption of organic solvent and pyraclostrobin, that is to say and control three's pesticide activity component
Dissolving amount in organic solvent so that in emulsion process, the emulsion of formation is more stablized.
In another embodiment, the oil-soluble cyst material and the consumption mass ratio of oil phase in step S01 are 1：
(9.5-26.5).By controlling the consumption of organic solvent and oil-soluble cyst material, the thickness for controlling microcapsule wall is that is to say,
The oil-soluble cyst material of the ratio so that can react to form complete microcapsules with water-soluble cyst material in follow-up
Wall, so as to realize the effective encapsulating to three's pesticide activity component.In a particular embodiment, the oil-soluble cyst material is hexichol
Methylene diisocyanate, polyphenyl polymethylene polyisocyanates, hexamethylene diisocyanate, IPDI,
1,4- cyclohexane diisocyanates, toluene di-isocyanate(TDI) or other contain the isocyanates of two or more isocyanate groups
The mixture of any one or more in compound.
The pyraclostrobin active compound of step S01, the former medicine of AVM and gamma cyhalothrin active compound pesticide activity into
Point and dissolve the preferred species of organic solvent of the pesticide activity component such as the pyraclostrobin contained in microcapsule formulation above
The species of active compound, the pesticide activity component of the former medicine of AVM and gamma cyhalothrin active compound and organic solvent, in order to save
About length, will not be repeated here.
In addition, mixing treatment in step S01 can be according to the conventional mixing treatment in this area, such as stir process, only
If enabling to three's pesticide activity component, oil-soluble cyst material fully to dissolve and being dispersed to formation stabilization in organic solvent
Uniform oil phase.
Emulsifying dispersant in above-mentioned steps S02 is improving emulsifying effectiveness in following step S03, in an embodiment, the breast
It is polyoxyethylene sorbitol fatty acid ester, castor oil polyoxyethylene ether, polycarboxylate, lignosulfonates, naphthalene to change dispersant
Sulfonate, Arabic gum, AEO, polyoxyethylene carboxylate, polyoxylethylene abietate, alkyl phenol polyoxy
Ethene polyethenoxy ether, aliphatic amine polyoxyethylene polyethenoxy ether, sodium alginate, carboxymethylcellulose calcium, phenylethylene-maleic anhydride
The mixture of any one or more in copolymer.The routine that its amount soluble in water can be prepared according to conventional emulsions contains
Amount.
In above-mentioned steps 03, the mixing shear treatment of the water phase prepared in the oil phase and step 02 prepared in above-mentioned steps 01
It is mutually to be sufficiently mixed with water in order that obtaining oil phase, and forms oil-in-water emulsion.The mixed proportion of the oil phase and water phase can be by
The conventional ratio prepared according to emulsion is mixed, such as in one embodiment, after the oil phase is mixed with water conjunction so that the emulsification point
Powder is 1 with the consumption mass ratio of oil phase：(8.3-43.3).In another embodiment, the O/W emulsions for being formed after shear treatment
The average grain diameter of drop is 0.5 μm~12 μm.By controlling O/W emulsion droplets size controllings, the control to final Microcapsules Size is realized
System, the average grain diameter for such as controlling microcapsule formulation is 0.5 μm~12 μm.
In above-mentioned steps 04, after water-soluble cyst material is added, it enters with oiliness cyst material in emulsion oil droplets superficial layer
Row polymerisation, production microcapsular envelopes that is to say microcapsule shell above.In one embodiment, the oil-soluble cyst wall material is controlled
The isocyanate functional group of material is 1 with the mol ratio of the amidine functional group of water-soluble cyst material：(0.5-1.3).The ratio
Can react to form complete microcapsule wall, the oil droplet in emulsion is effectively encapsulated.In a particular embodiment, it is described water-soluble
Property cyst material be ethylenediamine, propane diamine, hexamethylene diamine, diethylenetriamine and triethylene tetramine, butanediamine, pentanediamine, phenylenediamine
Or the mixture of any one or more in the aminated compounds containing two or more amido.
Therefore, in the various embodiments described above microcapsule formulation preparation method by pyraclostrobin, AVM and efficient chlorine fluorine
Cyano chrysanthemate three pesticide activity is configured to oil phase into oil-soluble cyst material so that three kinds of pesticide activities work as emulsion into mutually mixed
After mixing with water-soluble cyst material so that oil-soluble cyst material carries out interface polymerization reaction generation with water-soluble cyst material
Microcapsules, and by three's pesticide activity into encapsulating wherein, so that three's pesticide activity component gives full play to Synergistic work
With, and with consistent release property and lasting effect, while destruction of the undesirable element to three's pesticide activity component effectively has been intercepted,
Improve microcapsule formulation and containing the microcapsule formulation medicament storage stability, delay degradation speed, and then improve
Bioavailability, improves prevention effect.In addition, its preparation technology is easily-controllable, the microcapsule formulation performance for preparing is effectively ensured
Stabilization, and effectively increase production efficiency, reduce production cost.Simultaneously cause prepare microcapsules average grain diameter it is small and
Uniformly.
In addition, the microcapsule formulation of preparation method preparation mentioned above is spray-dried to be prepared into powderous preparations, can stick
Be attached to and granule be prepared on pelleted substrate, micro-capsule suspension emulsion can be mixed into other creamy formulations, can also and other
Aqueous suspension preparation is mixed into microcapsule suspension-suspendinagent agent etc..In addition, before powderous preparations, granule are prepared and outstanding preparing
Before or during emulsion, warning coloration pigment can also be added so that the medicament containing microcapsules mentioned above can be treatment
Seed so that processed seed can play identification alarm effect, it is to avoid be used for food or feed manufacturing.Warning coloration pigment
Can be the warning coloration pigment of species commonly used in the art and consumption.
On the other hand, on the basis of microcapsule formulation mentioned above and preparation method thereof, the embodiment of the present invention is also provided
A kind of micro-capsule suspension.The micro-capsule suspension includes aaerosol solution carrier and is suspended in the aaerosol solution carrier
Microcapsules.Wherein, the microcapsules are embodiment of the present invention microcapsule formulation or this hair by mentioned earlier mentioned above
Microcapsule formulation prepared by bright embodiment microcapsule formulation preparation method.Aaerosol solution carrier can be that this area suspending agent is commonly used
Aaerosol solution.
In one embodiment, the aaerosol solution carrier of above-mentioned micro-capsule suspension is the aqueous solution containing water-soluble additive.
In a further embodiment, the water-soluble additive be pH adjusting agent, antifreeze, film forming agent, preservative and defoamer at least
It is a kind of.Counted as 100% with the micro-capsule suspension gross mass, the freeze proof agent content is 4.0%-12.0%, film forming agent contains
It is 0.2%-1.0% to measure, and antiseptic content is 0.1%-0.5%, antifoam content is 0.1%-0.5%, and pH adjusting agent contains
Amount ensures that the pH of above-mentioned micro-capsule suspension is 6-7.In addition, the water-soluble additive can also include warning coloration pigment.The warning
Color pigment can be the warning coloration pigment of the conventional species and consumption for processing seed.
In a particular embodiment, the antifreeze contained by above-mentioned micro-capsule suspension is but is not limited to ethylene glycol, propane diols, third
The mixture of any one or more in triol, urea, ammonium sulfate, ammonium nitrate, magnesium sulfate, glucose, sucrose.Another
In specific embodiment, the film forming agent is but is not limited to xanthans, polyvinyl alcohol, polyvinylpyrrolidone, styrene-maleic acid
The mixture of any one or more in anhydride copolymer, sodium alginate, hydroxymethyl cellulose.In another specific embodiment
In, the mixture of any one or two kinds of that the preservative is but is not limited in Sodium Benzoate or OIT.In another tool
In body embodiment, the defoamer is but is not limited to organic silicon defoamer.In another specific embodiment, the pH adjusting agent is
But it is not limited to the mixture of the conventional organic acid of agricultural chemicals or inorganic acid or organic acid and inorganic acid；Wherein, organic acid can be with
But it is not limited to glacial acetic acid, formic acid, propionic acid, butyric acid etc.；Inorganic acid can be, but not limited to hydrochloric acid, phosphoric acid, sulfuric acid etc..Those additives
Presence, it is possible to increase the stability of above-mentioned micro-capsule suspension, anti-corrosive properties and the performance such as freeze proof.
Therefore, above-mentioned micro-capsule suspension is with microcapsules containing three's active component above due to forming suspending agent, from
And cause that the pesticide activity component contained by embodiment of the present invention micro-capsule suspension gives full play to synergistic function, and with one
The release property and lasting effect of cause, while effectively having intercepted destruction of the undesirable element to three's pesticide activity component, improve micro- glue
Capsule suspending agent storage stability, has delayed degradation speed, and then improves bioavailability, improves prevention effect, such as has concurrently
Desinsection, sterilization, mite killing and nematocidal effect, can be used for paddy rice, corn, the seed Dressing of potatoes and other crops or growth period
Root irrigation prevents and treats the disease pest at underground position.
Now by taking specific microcapsule formulation and preparation method and micro-capsule suspension as an example, the present invention is carried out further in detail
Describe in detail bright.
Embodiment 1
The present embodiment provides a kind of pyraclostrobin AVM gamma cyhalothrin microcapsule formulation and 20%
Micro-capsule suspension and preparation method thereof.
The present embodiment microcapsule formulation with 1, the microcapsules film layer that hexamethylene-diisocyanate is formed with ethylenediamine polymerisation,
The isocyanate functional group of oil-soluble cyst material is 1 with the mol ratio of the amidine functional group of water-soluble cyst material：1, its
Encapsulating mass ratio is 2.5: 2.5: 15.0 pyraclostrobin AVM gamma cyhalothrin active component.
The preparation method of the micro-capsule suspension of the present embodiment 20%：
S11：26.0g pyraclostrobins active compound (96.0%), 26.3g the former medicine of AVM (95.0%) and 154.6g is high
Effect lambda-cyhalothrin active compound (97.0%) is dissolved in the mixed solvent of 100.0g solvent naphthas S-150 and 10.0g sec-Butyl Acetates, plus
Enter hexamethylene diisocyanate (HMDI) 25.0g and stir to be prepared into oil phase；
S12：By 20.0g lignosulfonates (Ultrazine NA) and 8.0g polyoxyethylene sorbitol fatty acid esters
(Tween-80) is prepared into water phase in being dissolved in 372g deionized waters；
S13：Oil phase is added to water phase, the O/W emulsions of shearing to 0.5 μm~12 μm of average grain diameter；
S14：10% ethylenediamine solution 89.5g, 30 DEG C of ± 5 DEG C of insulation reaction 2.0h are slowly added under stirring, are cooled to
Room temperature；
S15：Addition 50.0g ethylene glycol, 20% polyvinyl alcohol of addition (502) 50.0g, organic silicon defoamer
1.0g and Sodium Benzoate 5.0g, pH value 6.0~7.0 is adjusted with glacial acetic acid, to go 10.0g ionized waters to supply 1000.0g, is stirred
Obtain final product 20% pyraclostrobin AVM gamma cyhalothrin micro-capsule suspension.
Wherein, step S11 to S14 is the preparation method of the present embodiment microcapsule formulation.
Embodiment 2
The present embodiment provides a kind of pyraclostrobin AVM gamma cyhalothrin microcapsule formulation and 18%
Micro-capsule suspension and preparation method thereof.
The present embodiment microcapsule formulation is with polyphenyl polymethylene polyisocyanates (isocyanate group content is 32.8%)
The microcapsules film layer formed with diethylenetriamine polymerisation, isocyanate functional group and the water solubility of oil-soluble cyst material
The mol ratio of the amidine functional group of cyst material is 1：1.3, its encapsulating mass ratio is 5.0：3.0：10.0 pyraclostrobin
AVM gamma cyhalothrin active component.
The preparation method of the micro-capsule suspension of the present embodiment 18%：
S21：52.1g pyraclostrobins active compound (96.0%), 31.6g the former medicine of AVM (95%), 103.1g is efficient
Lambda-cyhalothrin active compound (97%) is dissolved in the mixed solvent of 150.0g solvent naphthas S-200 and 13.2g isobutyl acetates, is added many
Phenyl polymethylene polyisocyanates (PAPI) 40.0g stirs and is prepared into oil phase；
S22：By 9.0g polycarboxylates (2700) it is dissolved in 360g deionized waters and is prepared into water phase；
S23：Oil phase is added to water phase, the O/W emulsions of shearing to 0.5 μm~12 μm of average grain diameter；
S24：It is slowly added to 40% diethylenetriamine aqueous solution 52.4g under stirring, 25 DEG C of ± 5 DEG C of insulation reaction 4.0h are cold
But to room temperature；
S25：Glycerine 50.0g, organic silicon defoamer 3.0g and OIT 1.0g are added, pH value is adjusted with 10% hydrochloric acid
6.0~7.0,2% xanthan gum solution 50.0g and 5% Arabic gum 20.0g is added, 1000.0g is supplied with deionized water,
Stir and obtain final product 18% pyraclostrobin AVM gamma cyhalothrin micro-capsule suspension.
Wherein, step S21 to S24 is the preparation method of the present embodiment microcapsule formulation.
Embodiment 3
The present embodiment provides a kind of pyraclostrobin AVM gamma cyhalothrin microcapsule formulation and 6% micro-
Capsule suspension and preparation method thereof.
The microcapsule membrane that the present embodiment microcapsule formulation is formed with hexichol methylene diisocyanate and propane diamine polymerisation
Layer, the isocyanate functional group of oil-soluble cyst material is 1 with the mol ratio of the amidine functional group of water-soluble cyst material：
0.8, its encapsulating mass ratio is 0.5：2.0：3.5 pyraclostrobin AVM gamma cyhalothrin active component.
The preparation method of the micro-capsule suspension of the present embodiment 6%：
S31：By 5.2g pyraclostrobins active compound (96.0%), 21.1g the former medicine of AVM (95%), the efficient chlorine of 36.1g
Flucythrinate active compound (97%) is dissolved in the mixed solvent of 200.0g trimethylbenzenes and 17.6g isobutyl acetates, adds hexichol methylene
Diisocyanate (MDI) 11.0g stirs and is prepared into oil phase；
S32：By 15.0g polycarboxylate polymeric dispersants (SINVO SP-2728) and 20.0g castor oil polyoxyethylene ethers
(By-125) it is dissolved in 360g deionized waters and is prepared into water phase；
S33：Oil phase is added to water phase, the O/W emulsions of shearing to 0.5 μm~12 μm of average grain diameter；
S34：10% propane diamine 26.2g, 40 DEG C of ± 5 DEG C of insulation reaction 0.5h are slowly added under stirring, room temperature is cooled to；
S35：Urea 100.0g is added, with 10% salt acid pH 6.0~7.0, organic silicon defoamer 2.0g, isothiazole is added
Quinoline ketone 2.0g, 2% xanthan gum solution 90.0g and polyvinylpyrrolidone (PVP-K30) 5.0g, are supplied with deionized water
1000.0g stirs, and obtains 6% pyraclostrobin AVM gamma cyhalothrin micro-capsule suspension.
Wherein, step S31 to S34 is the preparation method of the present embodiment microcapsule formulation.
Embodiment 4
The present embodiment provides a kind of pyraclostrobin AVM gamma cyhalothrin microcapsule formulation and 12%
Micro-capsule suspension and preparation method thereof.
The microcapsules that the present embodiment microcapsule formulation is formed with hexamethylene diisocyanate and triethylene tetramine polymerisation
Film layer, the isocyanate functional group of oil-soluble cyst material is 1 with the mol ratio of the amidine functional group of water-soluble cyst material：
0.5, its encapsulating mass ratio is 4.0：3.0：5.0 pyraclostrobin AVM gamma cyhalothrin active component.
The preparation method of the micro-capsule suspension of the present embodiment 12%：
S41：By 41.7g pyraclostrobins active compound (96.0%), 31.6g the former medicine of AVM (95%), the efficient chlorine of 51.5g
Flucythrinate active compound (97%) is dissolved in the mixed solvent of 175.0g solvent naphthas S-150 and 17.5g sec-Butyl Acetates, adds 1,6-
Hexamethylene diisocyanate (HMDI) 28.9g, stirs and is prepared into oil phase；
S42：By the acid of 10.0g Arabic gums, 10.0g naphthalene sulfonates (Morwet D-425) and 5.0g sorbitan fatties
Ester APEO (Tween-80), it is dissolved in 380g deionized waters and is prepared into water phase；
S43：Oil phase is added to water phase, the O/W emulsions of shearing to 0.5 μm~12 μm of average grain diameter；
S44：It is slowly added to 50% triethylene tetramine aqueous solution 25.0g under stirring, 60 DEG C of ± 5 DEG C of insulation reaction 3.0h are cold
But to room temperature；
S44：Ammonium sulfate 120.0g, organic silicon defoamer 4.0g and Sodium Benzoate 3.0g are added, pH value 6.0 is adjusted with glacial acetic acid
~7.0,2% xanthan gum solution 50.0g and polyvinylpyrrolidone (PVP-K90) 3.0g is added, supplied with deionized water
1000.0g, stirs and obtains final product 12% pyraclostrobin AVM lambda-cyhalothrin microcapsule suspension.
Wherein, step S41 to S44 is the preparation method of the present embodiment microcapsule formulation.
Embodiment 5
The present embodiment provides a kind of pyraclostrobin AVM gamma cyhalothrin microcapsule formulation and 15%
Micro-capsule suspension and preparation method thereof.
The present embodiment microcapsule formulation is with IPDI (IPDI) and polyphenyl polymethylene polyisocyanic acid
The microcapsules film layer that ester (PAPI) is formed with hexamethylene diamine and diethylenetriamine polymerisation, the isocyanates of oil-soluble cyst material
Base functional group is 1 with the mol ratio of the amidine functional group of water-soluble cyst material：1.2, its encapsulating mass ratio is 3.0：5.0：7.0
Pyraclostrobin AVM gamma cyhalothrin active component.
The preparation method of the micro-capsule suspension of the present embodiment 15%：
S51：By 31.3g pyraclostrobins active compound (96.0%), 52.6g the former medicine of AVM (95%), the efficient chlorine of 72.2g
Flucythrinate active compound (97%) is dissolved in the mixed solvent of 175.0g solvent naphthas S-200 and 20g acetic acid osmanthus ester, adds isophorone
Diisocyanate (IPDI) 8.3g and polyphenyl polymethylene polyisocyanates (PAPI) 10.0g, stirs and is prepared into oil phase；
S52：By 10.0g sodium lignin sulfonates (Borresperse NA) and 10.0g polycarboxylates (SINVO SP-2728)
It is dissolved in 400g deionized waters and is prepared into water phase；
S53：Oil phase is added to water phase, the O/W emulsions of shearing to 0.5 μm~12 μm of average grain diameter；
S54：40% hexamethylene diamine aqueous solution 15.0g and 40% diethylenetriamine aqueous solution 10.0g, 30 are slowly added under stirring
DEG C ± 5 DEG C of insulation reaction 3.0h, are cooled to room temperature；
S55：Glycerine 80.0g, organic silicon defoamer 3.0g and Sodium Benzoate 4.0g are added, pH value 6.0 is adjusted with glacial acetic acid
~7.0, add 2% xanthan gum solution 20.0g and 20% polyvinyl alcohol (205) 25.0g, is supplied with deionized water
1000.0g, stirs and obtains final product 15% pyraclostrobin AVM lambda-cyhalothrin microcapsule suspension.
Wherein, step S51 to S54 is the preparation method of the present embodiment microcapsule formulation.
Embodiment 6
The present embodiment provides a kind of pyraclostrobin AVM gamma cyhalothrin microcapsule formulation and 9% micro-
Capsule suspension and preparation method thereof.
The present embodiment microcapsule formulation is with hexamethylene diisocyanate (HMDI) and polyphenyl polymethylene polyisocyanates
(PAPI) the microcapsules film layer formed with the triethylene tetramine aqueous solution and ethylenediamine polymerisation, the isocyanide of oil-soluble cyst material
Perester radical functional group is 1 with the mol ratio of the amidine functional group of water-soluble cyst material：0.7, its encapsulating mass ratio is 1.0：
4.0：4.0 pyraclostrobin AVM gamma cyhalothrin active component.
The preparation method of the micro-capsule suspension of the present embodiment 9%：
S61：By 10.4g pyraclostrobins active compound (96.0%), 42.1g the former medicine of AVM (95%), the efficient chlorine of 41.2g
Flucythrinate active compound (97%) is dissolved in the mixed solvent of 190.0g solvent naphthas S-200 and 35g acetic acid osmanthus ester, add 1,6- oneself two
Isocyanates (HMDI) 13.5g and polyphenyl polymethylene polyisocyanates (PAPI) 20.0g, stirs and is prepared into oil phase；
S62：10.0g sodium lignin sulfonates (Reax 105M) are dissolved in water phase is prepared into 400g deionized waters；
S63：Oil phase is added to water phase, the O/W emulsions of shearing to 0.5 μm~12 μm of average grain diameter；
S64：50% triethylene tetramine aqueous solution 28.5g and 10% ethylenediamine solution 8.0g, 50 are slowly added under stirring
DEG C ± 5 DEG C of insulation reaction 2.0h, are cooled to room temperature；
S65：Ethylene glycol 40.0g, organic silicon defoamer 5.0g, OIT 3.0g are added, pH value is adjusted with 20% phosphoric acid
6.0~7.0,20% polyvinyl alcohol of addition (205) 40.0g, 1000.0g is supplied with deionized water, is stirred i.e.
Obtain 9% pyraclostrobin AVM lambda-cyhalothrin microcapsule suspension.
Wherein, step S61 to S64 is the preparation method of the present embodiment microcapsule formulation.
Correlated performance is tested
Below by the micro-capsule suspension that seeds secure experiment and test of pesticide effectiveness explanation embodiment of the present invention 1-6 are provided
It is safe to paddy rice, corn, the seed of potato or potato seed, can control the harm of seedling stage or even whole growth period disease pest.
1. seeds secure experiment：
Implemented using the standard method used in seed industry, to the micro- glue for having used embodiment of the present invention 1-6 to provide
It is of the invention to verify that the seed of paddy rice, corn and potato that capsule suspending agent is processed respectively or potato seed carry out indoor pot experiment
Preparation is safe to seed.Measure germination percentage within 6 months after treatment, result of the test is shown in Table 1.
The seeds secure result of the test of table 1
As shown in Table 1, seed or potato seed that the micro-capsule suspension for being provided using invention formulation embodiment 1 to 6 is processed,
Its germination percentage is suitable with untreated control, to being safe for examination crop seed.
In table 2 below field medicine effect test explanation the embodiment of the present invention 1 to 6 provide micro-capsule suspension by seed dressing or
Root irrigation, can control the harm of seedling stage or even whole growth period disease pest, significantly improve crop yield.Experiment comparison medicament used
It is the pyraclostrobin suspension seed-coating agent of commercially available medicament 18%, 5% avermectin microcapsule suspending agent and 10% efficient cyhalothrin
The mixture of ester Seed Treatment microcapsule suspending agent, is shown in Table 2.
The field medicine effect test medicament list of table 2
2. rice seedling seedling stage underground insect pest preventing and controlling field medicine effect test：
The micro-capsule suspension that embodiment 2 and embodiment 4 are provided is right with 20g (a.i./100kg seeds) Dressing
According to the mixture C K2 and CK4 that medicament is commercially available medicament.For studying thing for No. 1 seed of semilate rice, seed dressing is sowed after 3 days, each treatment region
Soil property and water, fertilizer management are consistent, and count each treatment region disease pest in rice seedling seedling stage a situation arises and in the rice harves phase
Count each treatment region yield.The most disease and pest in experimental plot rice seedling seedling stage is damping-off, Ditylenchus dipsaci and Lissorhoptrus oryzophilus Kuschel.Table 3 is for everywhere
Reason area's seedling stage insect pest preventing and controlling effect and per mu yield, show that the prevention effect and per mu yield of example of formulations 2 and embodiment 4 are significantly high
In the preventive effect of the mixture C K2 and CK2 of identical active component and the commercial preparation of content.
The rice seedling seedling stage underground insect pest preventing and controlling field medicine effect test result of table 3
3. Maize at Seedling Stage underground insect pest preventing and controlling field medicine effect test：
The micro-capsule suspension that embodiment 1 and embodiment 6 are provided is right with 20g (a.i./100kg seeds) Dressing
According to the mixture C K1 and CK6 that medicament is commercially available medicament.It is first beautiful 335 seed for studying thing, seed dressing is sowed after 3 days, each treatment region
Soil property and water, fertilizer management are consistent, and count each treatment region disease pest a situation arises in corn trumpet period and in rice harves
Phase counts each treatment region yield.The most disease and pest of experimental plot corn is seedling blight, Ditylenchus dipsaci and mole cricket, and table 4 is each treatment region disease
Worm prevention effect and per mu yield, show that example of formulations 1 and the prevention effect and per mu yield of embodiment 6 are significantly higher than identical activity
The preventive effect of the mixture C K1 and CK6 of the commercial preparation of component and content.
The Maize at Seedling Stage underground insect pest preventing and controlling field medicine effect test result of table 4
4. potato underground insect pest preventing and controlling field medicine effect test：
Choose crop growing state consistent, soil property is consistent, the consistent potato fields of water, fertilizer management, trial crops are grams new No. four,
The most disease and pest of experimental plot potato is powdery scab, Ditylenchus dipsaci and black cutworm.Reagent agent is that embodiment 3 and embodiment 5 are carried
The micro-capsule suspension of confession, comparison medicament is the mixture C K3 and CK5 of commercially available medicament.In the potato 6-8 piece leaf phases with 30g
A.i./mu is watered to 20 kilograms of liquid root irrigations, and a situation arises and per mu yield for each treatment disease pest of harvest time statistics.Table 5 is each
Treatment region insect pest preventing and controlling effect and per mu yield, show that the prevention effect and per mu yield of the preparation of embodiment 3 and embodiment 5 are significantly high
In the preventive effect of the mixture C K3 and CK5 of identical active component and the commercial preparation of content.
The potato underground insect pest preventing and controlling field medicine effect test result of table 5
From above-mentioned table 1,3-5, embodiment of the present invention micro-capsule suspension due to being with embodiment of the present invention microcapsules
Active component forms suspending agent, so that the pesticide activity component contained by embodiment of the present invention micro-capsule suspension gives full play to
Synergistic function, and with consistent release property and lasting effect, while effectively having intercepted undesirable element to three's pesticide activity
The destruction of composition, improves micro-capsule suspension storage stability, has delayed degradation speed, and then improves bioavailability,
Prevention effect is improve, desinsection, sterilization, mite killing and nematocidal effect is such as had concurrently, can be used for paddy rice, corn, potatoes and other crops
Seed Dressing or growth period root irrigation prevent and treat underground position disease pest, improve the yield of crop.
Presently preferred embodiments of the present invention is the foregoing is only, is not intended to limit the invention, it is all in essence of the invention
Any modification, equivalent and improvement made within god and principle etc., should be included within the scope of the present invention.
Claims (10)
1. a kind of microcapsule formulation, including microcapsule shell and the pesticide activity component being encapsulated in the microcapsule shell body,
It is characterized in that：The pesticide activity component includes pyraclostrobin, AVM and gamma cyhalothrin.
2. microcapsule formulation according to claim 1, it is characterised in that：The pyraclostrobin, AVM and efficiently
The mass ratio of lambda-cyhalothrin is 1：(0.4-10.0)：(0.7-30.0)；And/or
The pesticide activity component is dissolved in organic solvent, and the organic solvent is with the mass ratio of the pyraclostrobin
(3.1-41.9)：1.
3. microcapsule formulation according to claim 2, it is characterised in that：The organic solvent is aromatic hydrocarbon solvent and acetic acid
The compound mixed solvent of esters solvent, wherein, the aromatic hydrocarbon solvent is (5.4- with the mass ratio of the acetates solvent
11.4)：1.
4. according to any described microcapsule formulations of claim 1-3, it is characterised in that：The average grain diameter of the microcapsule formulation
It is 0.5 μm~12 μm.
5. the preparation method of the microcapsule formulation as described in claim 1-4 is any, comprises the following steps：
After pyraclostrobin active compound, the former medicine of AVM and gamma cyhalothrin active compound are dissolved in into organic solvent, oil soluble is added
Property cyst material carries out mixing treatment, is configured to oil phase；
Emulsifying dispersant is soluble in water, it is configured to water phase；
By the water phase and the blended shear treatment of the oil phase, O/W emulsions are formed；
Interface polymerization reaction is carried out to water-soluble cyst material is added in the O/W emulsions.
6. preparation method according to claim 5, it is characterised in that：In the oil phase, the pyraclostrobin active compound, Ah
The active matter of dimension rhzomorph active compound and gamma cyhalothrin active compound rolls over the mass ratio 1 of hundred consumptions：(0.4-10.0)：(0.7-
30.0)；And/or
The organic solvent is (3.1-41.9) with the consumption mass ratio of the pyraclostrobin：1；And/or
The oil-soluble cyst material is 1 with the consumption mass ratio of oil phase：(9.5-26.5)；And/or
The mol ratio of the amidine functional group of the isocyanate functional group of the oil-soluble cyst material and water-soluble cyst material
It is 1：(0.5-1.3)；And/or
The emulsifying dispersant is 1 with the consumption mass ratio of oil phase：(8.3-43.3).
7. the preparation method according to claim 5 or 6, it is characterised in that：The oil-soluble cyst material is hexichol methylene
In diisocyanate, poly methylene poly phenyl poly isocyanate, hexamethylene diisocyanate and IPDI
The mixture of any one or more；
The water-soluble cyst material is any one in ethylenediamine, propane diamine, hexamethylene diamine, diethylenetriamine and triethylene tetramine
Or two or more mixtures；
The emulsifying dispersant is polyoxyethylene sorbitol fatty acid ester, castor oil polyoxyethylene ether, polycarboxylate, lignin
The mixture of any one or more in sulfonate, naphthalene sulfonate and Arabic gum.
8. a kind of micro-capsule suspension, it is characterised in that：Including aaerosol solution carrier and being suspended in the aaerosol solution carrier
Microcapsules, the microcapsules are any described microcapsule formulations of claim 1-4 or any described by claim 5-7
Microcapsule formulation prepared by preparation method.
9. micro-capsule suspension according to claim 8, it is characterised in that：It is with the micro-capsule suspension gross mass
100% meter, also including accounting for pH adjusting agent, the antifreeze of 4.0%-12.0%, the 0.2%- of the micro-capsule suspension gross mass
At least one in 1.0% film forming agent, 0.1%-0.5% preservatives, 0.1%-0.5% defoamers.
10. micro-capsule suspension according to claim 9, it is characterised in that：The antifreeze be ethylene glycol, propane diols,
The mixture of any one or more in glycerine, urea and ammonium sulfate；
The film forming agent is the mixture of any one or more in xanthans, polyvinyl alcohol and polyvinylpyrrolidone；
The preservative is the mixture of any one or two kinds of in Sodium Benzoate or OIT；
The defoamer is organic silicon defoamer；
The pH adjusting agent is the mixture of any one or more in glacial acetic acid, phosphoric acid or hydrochloric acid.
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