CN106798749A - A kind of PVP-I film forming sterilizing agent and its preparation method and application - Google Patents
A kind of PVP-I film forming sterilizing agent and its preparation method and application Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
- A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
- A61K31/79—Polymers of vinyl pyrrolidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
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Abstract
The invention provides a kind of PVP-I film forming sterilizing agent, the disinfectant is Carbomer, the percentage by weight of 0.1-0.5% for the PVP and percentage by weight of 1-10% are the Potassiumiodate of 0.1-0.5% including PVP-I that percentage by weight is 5%, percentage by weight.The invention also discloses the preparation method and application of PVP-I film forming sterilizing agent.Available iodine content and pH stabilizations after PVP-I film forming sterilizing agent of the present invention placement for a long time; it is long placed in not stratified; solution good fluidity, and the solution can form one layer of disinfectant diaphragm that can die away in mammilla of milk cattle, can effectively prevent the generation of mastitis for milk cows.
Description
Technical field
The invention belongs to veterinary biologicses technical field, and in particular to a kind of PVP-I film forming sterilizing agent and its preparation
Methods and applications.
Background technology
Mammitis is one of three big diseases of milk cow, and China's mastadenitis of cow incidence of disease is up to 20-60%, and it can reduce milk
The ox output of milk and milk quality, not only increase medical expense, it is also possible to cause discarded milk, severe patient to have an effect on the heat of milk cow
And gestation；Some infected cattles are forced to eliminate because milk production is significantly reduced or loses milking capacity, therefore mastitis is to cause milk cow
One of major reason of production economy loss.Mastitis has three key factors, and one is the infection sources, and two is to propagate way
Footpath, three is susceptible animal.In most cases, after cow breast infection occurs mainly in milking and milks, cause of disease passes through
The hand of the person of milking, the towel and teatcup for cleaning breast enter breast through ductus papillaris；After particularly milking, mammilla of milk cattle pipe is opened
Put, milk cow rests sleepingly, pathogen is easy to invade breast by ductus papillaris in environment.Breast infection is heavily dependent on
By ductus papillaris enter breast microorganism value volume and range of product, therefore prevention mastadenitis of cow generation, from cut-out cause of disease it is micro-
Biological route of transmission is started with, and is more satisfactory selection approach.
At present, drug immersion mammilla of milk cattle is a kind of to prevent and treat mammitis effective measures simple and easy to apply.Traditional dip warp
The development of common Iodophor, hydrogen peroxide and various sterilization dips has been gone through, but these dipping products are all to kill simple moment
Bacterium and sterilization, and when mastitis for milk cows incidence of disease highest it is institute in this 15 minutes before nipple closure after having squeezed milk
Pathogenic bacterial infection cannot be prevented with traditional dip instantaneous sterilization but persistently, because its sterilizing rate duration is short, at all cannot be thorough
Bottom ground prevention mastitis for milk cows, causes the mastitis for milk cows incidence of disease to remain high.Reply mastadenitis of cow prevents the best way
It is that precautionary measures are used to environmental pathogenic bacteria, to reduce the chance of skin of nipple contact bacterium as far as possible and prevent bacterium from entering breast
Based on gland.
In addition, the disinfectant being commonly used in the prior art is povidone iodine disinfectant.The disinfectant it is main effectively into
It is divided into PVP-I, is the amorphous soluble complex combined to form by polyvinylpyrrolidone and iodine, belongs to the one of Iodophor
Kind.PVP-I has broad-spectrum antibacterial action, and bactericidal action is quick, medicine persistent reliability, and nonirritant, is safe height
The disinfection sanitizer of effect.But due to there are various iodine-type bodies and volatile in PVP-I, under different pH value, available iodine contains
Amount change is very big, and Betagen Solution pH value is unstable, and fall is very big.Betagen Solution in the market contains
Amount is often unstable, and available iodine content declines soon, directly affects its therapeutic effect.Clinically, PVP-I is generally existing with first
With, using very inconvenient, keeping life is short, not only quality it cannot be guaranteed that, also result in substantial amounts of waste.In addition, existing at present
Povidone iodine disinfectant (a kind of povidone iodine gel as disclosed in Chinese patent application CN102657600A) prescription in contain third
Triol and pH buffer solutions such as sodium dihydrogen phosphate and disodium hydrogen phosphate, the product prepared according to this prescription are easily layered after placing, and have
Effect content of iodine declines soon, and stability of solution is bad, so as to have impact on using effect.
Therefore it is badly in need of a kind of energy Continuous sterilization of production in clinical practice, is long placed in and is difficult layering, good fluidity, active ingredient point
Dissipate uniform, the povidone iodine disinfectant of available iodine content stabilization.
The content of the invention
The present invention is to overcome the deficiencies in the prior art, there is provided a kind of containing the film forming sterilizing agent of PVP-I and its preparation side
Method and application.
The first aspect of the present invention is related to a kind of PVP-I film forming sterilizing agent, the disinfectant to be including percentage by weight
Carbomer, PVP and weight percent that percentage by weight be 1-10% of 5% PVP-I, percentage by weight for 0.1-0.5%
Than the Potassiumiodate for 0.1-0.5%.
PVP-I film forming sterilizing agent prepared by the present invention, after the nipple dipping of the milk cow solution, in nipple surface energy
One layer of protective film is quickly formed, nipple surface is wrapped in, the special efficacy iodine that PVP-I is produced can kill Supramammillary bacterium, its
Barrier is formed between the bacterium that the film of formation can be in nipple and environment, prevents pathogenic microorganism from invading mammary gland by the nipple mouth of pipe
Tissue, and nipple is protected between milking twice, pathogenic infection in environment is prevented, pathogenic bacterial infection approach is cut off, can be effective
Prevent the generation of mastitis for milk cows.Also, PVP-I film forming sterilizing agent available iodine content of the invention and pH stabilizations, are long placed in not
Layering, solution mobility and film forming are good, and stability test data display solution is relatively stablized.
Another aspect of the present invention is related to a kind of method for preparing PVP-I film forming sterilizing agent of the present invention, described
Method is comprised the following steps：(1) Carbomer mother liquor, PVP mother liquors and Potassiumiodate mother liquor are prepared respectively, wherein regulation Carbomer mother liquor
PH to 6.0-6.5；(2) stirred to the PVP mother liquors and Potassiumiodate mother liquor is added in the Carbomer mother liquor in proportion
It is translucent homogeneous gel-like substance to solution；(3) PVP-I bulk drug is added in the solution for obtaining to the step (2),
Stirring；And (4) emulsification, adjust pH to 5.5-5.7.
PVP-I film forming sterilizing agent prepared by preparation method of the invention ensure that PVP-I film forming sterilizing agent solution
Available iodine content stability；The film forming of PVP-I film forming sterilizing agent solution；PVP-I film forming sterilizing agent solution PH stabilization
Property；And solve disinfectant solution lamination problem；And povidone iodine disinfectant solution good fluidity, active ingredient is uniformly dispersed.
Prevention and treatment milk cow's milk is being prepared the invention further relates to PVP-I film forming sterilizing agent prepared by a kind of present invention
Application in the medicine of adenositis.
Specific embodiment
Hereinafter, embodiments of the present invention are illustrated.
The first aspect of the present invention is to provide a kind of PVP-I film forming sterilizing agent, and the disinfectant includes weight percent
Carbomer, the PVP and weight that percentage by weight is 1-10% than the PVP-I for 5%, percentage by weight for 0.1-0.5%
Percentage is the Potassiumiodate of 0.1-0.5%.
As a kind of preferred embodiment of the invention, in the disinfectant of the invention, the weight of the PVP-I
Percentage be the 5%, Carbomer percentage by weight be 0.2-0.4%, the percentage by weight of the PVP be 2-5%, described
The percentage by weight of Potassiumiodate is 0.2-0.4%.
As a kind of most preferred embodiment of the invention, in the disinfectant of the invention, the weight of the PVP-I
Amount percentage is that the percentage by weight that the 5%, percentage by weight of the Carbomer is the 0.4%, PVP is the 5%, acid iodide
The percentage by weight of potassium is 0.2%.
Used as one embodiment of the present invention, in the disinfectant of the invention, available iodine content is 8.5%-
12.0%.
Used as a kind of preferred embodiment of the invention, in the disinfectant of the invention, the Carbomer is Carbomer
934, the PVP are PVP-K30.
" PVP " is the abbreviation of Polyvinyl pyrrolidone, and PVP, chemical name is polyvinylpyrrolidone, is
A kind of high molecular weight water soluble polymer, monomer is N-Vinyl pyrrolidone (NVP), is one
Plant non-ionic macromolecule compound.Its effect in the present invention is to increase product film forming and solution mobility, solution
The raising of mobility can make active ingredient dispersed wherein.PVP is divided into level Four by its mean molecule quantity size, traditionally often with
K values represent that different K values represent corresponding PVP average molecular weight ranges respectively.K values are actually relative with the PVP aqueous solution
The relevant characteristic value of viscosity, and viscosity is the physical quantity relevant with molecular weight of high polymer, therefore PVP can be characterized with K values
Mean molecule quantity.Usual K values are bigger, and its viscosity is bigger, and cementability is stronger.Common PVP include PVP-K25, PVP-K30,
PVP-K90 etc..Used as a kind of preferred embodiment of the invention, in the disinfectant of the invention, the PVP is PVP-K30.
" Carbomer " is a kind of high-molecular-weight propylene acid cross-linked polymer of synthesis, and its effect in the present invention is to increase
Plus product film forming and the adhesion of solution can be improved, disinfectant is adhered on cow papillary skin will not flow down, and be formed
Thin film, can voluntarily fading after certain hour.Carbomer can be divided into 934,940,941 etc. by viscosity.As of the invention
A kind of preferred embodiment, in the disinfectant of the invention, the Carbomer is carbomer 934.
" Potassiumiodate " in the present invention act as stabilizer, make solution content stabilization, and can indirectly improve solution PH
Stability.
It is another aspect of the invention to provide a kind of method for preparing PVP-I film forming sterilizing agent of the present invention, its
It is characterised by, the described method comprises the following steps：
(1) Carbomer mother liquor, PVP mother liquors and Potassiumiodate mother liquor are prepared respectively in proportion, wherein regulation Carbomer mother liquor
PH to 6.0-6.5；(2) to the PVP mother liquors and Potassiumiodate mother liquor is added in the Carbomer mother liquor, it is evenly stirred until that solution is in
Translucent homogeneous gel-like substance；(3) PVP-I bulk drug, stirring are added in the solution for obtaining to the step (2)；And
(4) emulsify, adjust pH to 5.5-5.7.
As one embodiment of the present invention, wrapped in PVP-I film forming sterilizing agent obtained in methods described of the invention
PVP-I, percentage by weight that percentage by weight is 5% are included for the Carbomer of 0.1-0.5%, percentage by weight are 1-10%
PVP and percentage by weight for 0.1-0.5% Potassiumiodate.
As a kind of preferred embodiment of the invention, PVP-I film forming sterilizing agent obtained in methods described of the invention
In, the percentage by weight of the PVP-I is that the percentage by weight of the 5%, Carbomer is 0.2-0.4%, the PVP
Percentage by weight is 2-5%, the percentage by weight of the Potassiumiodate is 0.2-0.4%.
As a kind of most preferred embodiment of the invention, PVP-I film forming sterilization obtained in methods described of the invention
In agent, the percentage by weight of the PVP-I is that the 5%, percentage by weight of the Carbomer is the 0.4%, weight of the PVP
Amount percentage is that the percentage by weight of the 5%, Potassiumiodate is 0.2%.It is of the invention as one embodiment of the present invention
1% carbomer solution is placed 24h by methods described in being additionally included in the step (1), swelling uniform, adjusts PH to 6.0-
6.5,115 DEG C of autoclaving 30min, cooling is standby, and the 50%PVP solution is placed into 15min；And in the step
(4) emulsification condition described in is the emulsified 10min of 1200r/min rotating speeds.
It is of the invention to the described method comprises the following steps as a kind of preferred embodiment of the invention：
(1) Carbomer mother liquor is prepared：Weigh during appropriate Carbomer adds the beaker for filling the desired amount of purified water, stir pure
Carbomer is slowly added to while changing water, Carbomer adition process should prevent caking from occurring, 24h is placed after the completion of preparation, swelling
Uniformly, PH is adjusted to 6.0-6.5 with NaOH solution afterwards, 115 DEG C of autoclaving 30min are standby after cooling,
Prepare PVP mother liquors：Weigh appropriate PVP to be placed in the beaker for filling the desired amount of purified water, stir, place
15min, after solution after PVP all dissolving in light yellow transparent liquid shape,
Prepare Potassiumiodate mother liquor：Take it is clean dry beaker and be placed in electronic balance, add appropriate Potassiumiodate, purified water, stir
Mix uniform to Potassiumiodate all dissolvings；
(2) to the PVP mother liquors and Potassiumiodate mother liquor is added in the Carbomer mother liquor, it is evenly stirred until solution in semi-transparent
Bright homogeneous gel-like substance；
(3) PVP-I bulk drug is added in the solution for obtaining to step (2), is stirred；And
(4) 10min, 1200r/min are emulsified with mulser, pH value to 5.5-5.7 is adjusted with NaOH solution.
Used as a kind of preferred embodiment of the invention, in methods described of the invention, the Carbomer is Carbomer
934, the PVP are PVP-K30.
As one embodiment of the present invention, the solution that will be obtained by the above method, according to the People's Republic of China (PRC)
Detection method under veterinary drug allusion quotation Betagen Solution determines available iodine content, and after measured, this product available iodine content is 8.5%-
12.0%.
The answering in the medicine for preparing prevention and treatment mastadenitis of cow the invention further relates to disinfectant of the present invention
With.
Used as one embodiment of the present invention, pharmaceutical dosage form prepared by disinfectant of the present invention is solution.
PVP-I film forming sterilizing agent of the present invention place for a long time after available iodine content and pH stabilizations, be long placed in regardless of
Layer, solution good fluidity, and the solution can form one layer of disinfectant diaphragm that can die away in mammilla of milk cattle, can have
The generation of effect prevention mastitis for milk cows.
The present invention is further described with reference to specific embodiment, advantages of the present invention and feature will be with description more
For clear.But these embodiments are only exemplary, do not constitute any limitation to the scope of the present invention.Those skilled in the art
It should be understood that can be carried out to the details of technical solution of the present invention and form without departing from the spirit and scope of the invention
Modification is replaced, but these modifications and replacement are each fallen within protection scope of the present invention.
The preparation example of the PVP-I film forming sterilizing agent of the present invention of embodiment 1
1 preparation example PVP-I film forming sterilizing agent of preparation example (per 1kg) includes following raw material：PVP-I：50g, card
Ripple nurse 934：1g、PVP-K30：10g, Potassiumiodate：1g, percentage by weight is respectively：PVP-I：5%th, carbomer 934：
0.1%th, PVP-K30：1%th, Potassiumiodate：0.1%.
Preparation process is as follows：
(1) carbomer 934 mother liquor is prepared：Weigh during 1g carbomer 934s add and fill the beaker of 99g purified waters, stir pure
Carbomer is slowly added to while changing water, Carbomer adition process should prevent caking from occurring.24h is placed after the completion of preparation, it is swelling
Uniformly, pH is adjusted to 6.0-6.5 with 4mol/LNaOH solution afterwards, 115 DEG C of autoclaving 30min are standby after cooling；
Prepare PVP-K30 mother liquors：Weigh 10gPVP-K30 to be placed in the beaker for filling 10g purified waters, stir, place
15min, after solution after PVP-K30 all dissolving in light yellow transparent liquid shape；
Prepare Potassiumiodate mother liquor：Take it is clean dry beaker and be placed in electronic balance, add 1g Potassiumiodates, 829g purified waters,
It is evenly stirred until that Potassiumiodate all dissolves；
(2) to adding the above-mentioned PVP-K30 mother liquors for preparing and Potassiumiodate female in the above-mentioned carbomer 934 mother liquor for preparing
Liquid, is evenly stirred until that solution is translucent homogeneous gel-like substance；
(3) 50g PVP-I bulk drugs are added in the solution for obtaining to step (2), is stirred, and
(4) 10min, 1200r/min are emulsified with mulser, pH value to 5.5-5.7 is adjusted with NaOH solution.
Above-mentioned solution is taken, determines effective according to the detection method under Republic of China Veterinary Pharmacopoeia Betagen Solution
Content of iodine, after measured, this product available iodine content is 10.22%.
With reference to above-mentioned preparation example 1 method and adjust the weight of each component raw material, the poly- of other preparation examples is prepared in proportion
Dimension ketone iodine film forming sterilizing agent.The percentage by weight of the component in other preparation examples is shown in Table 1.
The preparation example of the present invention of table 1
The Stability Determination of the PVP-I film forming antiseptic solution of the present invention of embodiment 2
The embodiment of the present invention 1 prepare Betagen Solution, its stability test according to《Chinese veterinary pharmacopoeia》2010 editions one
Portion checks, and inspection project includes：Proterties, pH value, discriminating, available iodine content, specification.Chinese veterinary pharmacopoeia required standard is as follows：
Proterties：Brown liquid；
PH value：3.0-6.5；
Differentiate：(1) this product 1-5 drops are taken, the 10ml that adds water drips with starch indicator 1, that is, shows bluish violet.(2) this product 10ml is taken
Put in 50ml conical flasks, bottleneck covers the filter paper moistened with starch indicator solution, places 60s, does not show blueness；
Available iodine content：Titrated using sodium thiosulfate, available iodine content should be the 8.5%-12.0% of labelled amount.
Stability test is using hot test, strong illumination experiment and preparation in accelerated test index investigation embodiment 1
The stability of Betagen Solution.
Hot test：During the Betagen Solution of preparation example 1~8 put into sealing clean Brown Glass Brown glass bottles and jars only, in 60 DEG C of conditions
Place 10 days, detected respectively at sampling in 0,5,10 days, according to《Chinese veterinary pharmacopoeia》2010 editions one relevant index of testing, knot
Fruit is shown in Table 2.
Strong illumination is tested：During the Betagen Solution of preparation example 1~8 put into sealing clean Brown Glass Brown glass bottles and jars only, in illumination
Placed 10 days under the conditions of 4500 ± 500Lx, detected respectively at sampling in the 0th, 5,10 days, according to《Chinese veterinary pharmacopoeia》2010 editions one
Test relevant index, the results are shown in Table 3.
Accelerated test：It is 40 in temperature during the Betagen Solution of preparation example 1~8 put into sealing clean Brown Glass Brown glass bottles and jars only
DEG C, place six months under the conditions of relative humidity 75%, in the 0th, 1,2,3, June sampling detection, according to《Chinese veterinary pharmacopoeia》2010
One relevant index of testing of version, the results are shown in Table 4.
The hot test result of table 2
The strong illumination result of the test of table 3
The accelerated test result of table 4
Knowable to stability test data, in high temperature, strong illumination and accelerated test, the appearance character of Betagen Solution
Without substantially change, solution is in brown liquid, is occurred without lamination, and pH value and available iodine content testing result meet rule
It is fixed.Result shows that Betagen Solution prepared in accordance with the present invention is long placed in rear each index and stablizes.
The filming performance of the PVP-I film forming antiseptic solution of the present invention of embodiment 3 is determined
3-4 monthly ages new zealand white rabbit 24, male and female half and half are purchased from experimental animal center of henan province.Using commercially available de-
Rabbit belly is lost hair or feathers in hair agent.The PVP-I film forming antiseptic solution of preparation example 1-8 is extracted three times respectively, is extracted every time
2ml solution, uniform application is in 3 × 4cm respectively2Rabbit belly, record to presentation quality is commented per the component film time and by table 5
Point.The comprehensive grading (being shown in Table 6) of each preparation example antiseptic solution is evaluated, standards of grading are total score=(30- film formation times)+outward appearance matter
Amount.
The presentation quality standards of grading table of table 5
| Presentation quality | Score |
| It is uniformly dispersed, color and luster is consistent, sticky good, good fluidity | 8 |
| It is uniformly dispersed, color and luster is consistent, viscosity is poor | 6 |
| It is uniformly dispersed, slightly has shade deviation | 4 |
| Decentralization is poor, shade deviation is more apparent | 2 |
| There is Precipitation | 0 |
Each preparation example antiseptic solution film formation time of table 6 and presentation quality measurement result and comprehensive grading
| Preparation example is numbered | Film formation time (min) | Presentation quality | Total score |
| 1 | 2.67 | 8 | 35.33 |
| 2 | 3.00 | 8 | 35.00 |
| 3 | 3.00 | 8 | 35.00 |
| 4 | 2.33 | 8 | 35.67 |
| 5 | 3.33 | 8 | 34.67 |
| 6 | 2.67 | 8 | 35.33 |
| 7 | 3.00 | 8 | 35.00 |
| 8 | 2.00 | 8 | 36.00 |
The film formation time and presentation quality measurement result of preparation example gained antiseptic solution show that 8 kinds of preparation example gained are sterilized
Solution film forming is fast, and film is uniformly dispersed, color and luster consistent, sticky good, good fluidity, and comprehensive grading is higher, wherein prepare 8 gained disappearing
The comprehensive grading highest of malicious solution.
The clinical application effect experiment of the PVP-I film forming antiseptic solution of the present invention of embodiment 4
Experimental animal and packet：Age 4-6 Sui, the milk cow of postpartum 3-5 month are chosen in Luoyang periphery cooperation cattle farm, should
Carried out screening 45 healthy cows with California mammitis detection method (CMT), be divided into 9 groups, every group 5.
Trial drug：The 8 kinds of PVP-I antiseptic solutions formed in preparation example 1-8 of the present invention.
Test method：Experimental animal is divided into 9 groups, including 8 administration groups and 1 control group.8 administration groups give respectively
8 kinds of PVP-I antiseptic solutions that preparation example 1-8 is formed, control group is tested using warm water instead of antiseptic solution.Administration group
Breast and nipple are cleaned with warm water before and after milking, nipple is dipped with antiseptic solution afterwards.Control group is only cleaned with warm water, is not used
Any disinfecting drug.The whole test period continues 30 days, and cow breast state is examined daily, checks ox with CMT methods weekly
Breast, detects each group mastadenitis of cow incidence, and each group milk cow morbidity newborn area's number is counted during off-test, the results are shown in Table 7, and then
Evaluate preventive effect of the preparation example 1-8 gained antiseptic solutions to mastadenitis of cow.
Each preparation example antiseptic solution clinical application effect measurement result of table 7
| Group | The newborn area's (individual) of experiment | The newborn area's (individual) of morbidity | Infection rate (%) | Prevention rate (%) |
| Preparation example 1 | 20 | 1 | 5 | 95 |
| Preparation example 2 | 20 | 2 | 10 | 90 |
| Preparation example 3 | 20 | 1 | 5 | 95 |
| Preparation example 4 | 20 | 1 | 5 | 95 |
| Preparation example 5 | 20 | 2 | 10 | 90 |
| Preparation example 6 | 20 | 1 | 5 | 95 |
| Preparation example 7 | 20 | 1 | 5 | 95 |
| Preparation example 8 | 20 | 0 | 0 | 100 |
| Control group | 20 | 8 | 40 | 60 |
As can be seen from Table 7, the control group milk cow's milk area incidence of disease is up to 40%, it can be seen that the mammitis morbidity of the cattle farm
Rate is higher, but using the present invention in antiseptic solution prevent cow subclinical mastitis after, prevention rate in the range of 90%-100%,
The incidence of disease can be substantially reduced.
The above is only the preferred embodiments of the present invention, and any formal limitation is not done to the present invention, though
So the present invention is disclosed above with preferred embodiment, but is not limited to the present invention, any to be familiar with this professional technology people
Member, not departing from the range of technical solution of the present invention, when making a little change using the technology contents of the disclosure above or repair
The Equivalent embodiments for equivalent variations are adornd, as long as being the content without departing from technical solution of the present invention, according to technology reality of the invention
Any simple modification, equivalent variations and modification that confrontation above example is made, still fall within the scope of technical solution of the present invention
It is interior.
Claims (10)
1. a kind of PVP-I film forming sterilizing agent, it is characterised in that the disinfectant includes PVP that percentage by weight is 5%
Iodine, percentage by weight are the Carbomer of 0.1-0.5%, percentage by weight for the PVP and percentage by weight of 1-10% are 0.1-
0.5% Potassiumiodate.
2. disinfectant according to claim 1, it is characterised in that in the disinfectant, the weight of the PVP-I
Percentage be the 5%, Carbomer percentage by weight be 0.2-0.4%, the percentage by weight of the PVP be 2-5%, described
The percentage by weight of Potassiumiodate is 0.2-0.4%.
3. disinfectant according to claim 1, it is characterised in that in the disinfectant, the weight of the PVP-I
Percentage is that the percentage by weight that the 5%, percentage by weight of the Carbomer is the 0.4%, PVP is the 5%, Potassiumiodate
Percentage by weight be 0.2%.
4. the disinfectant according to claim any one of 1-3, it is characterised in that in the disinfectant, the Carbomer
It is carbomer 934, the PVP is PVP-K30.
5. disinfectant according to claim 1, it is characterised in that available iodine content is 8.5%-12.0%.
6. a kind of method for preparing PVP-I film forming sterilizing agent according to claim 1, it is characterised in that methods described bag
Include following steps：
(1) Carbomer mother liquor, PVP mother liquors and Potassiumiodate mother liquor are prepared respectively in proportion, wherein the pH of regulation Carbomer mother liquor to
6.0-6.5；
(2) to the PVP mother liquors and Potassiumiodate mother liquor is added in the Carbomer mother liquor, it is evenly stirred until that solution is translucent even
Matter gel-like substance；
(3) PVP-I bulk drug, stirring are added in the solution for obtaining to the step (2)；And
(4) emulsify, adjust pH to 5.5-5.7.
7. method according to claim 6, it is characterised in that wrapped in PVP-I film forming sterilizing agent obtained in methods described
PVP-I, percentage by weight that percentage by weight is 5% are included for the Carbomer of 0.1-0.5%, percentage by weight are 1-10%
PVP and percentage by weight for 0.1-0.5% Potassiumiodate；Preferably, the Carbomer is carbomer 934, and the PVP is
PVP-K30。
8. method according to claim 6, it is characterised in that methods described is additionally included in the card ripple in step (1)
Nurse mother liquor places 24h, swelling uniform, and PH is to 6.0-6.5 for regulation, and 115 DEG C of autoclaving 30min, cooling is standby, and will be described
PVP mother liquors place 15min；And in the step (4), the emulsification condition is the emulsified 10min of 1200r/min rotating speeds.
9. the disinfectant according to any one of Claims 1 to 5 is in the medicine for preparing prevention and treatment mastadenitis of cow
Using.
10. application according to claim 9, it is characterised in that the pharmaceutical dosage form is solution.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108079120A (en) * | 2017-12-06 | 2018-05-29 | 常州三伊化工有限公司 | A kind of cow teats disinfectant |
| CN108403671A (en) * | 2018-06-11 | 2018-08-17 | 佛山市南海东方澳龙制药有限公司 | Betagen Solution and preparation method thereof |
| WO2020233371A1 (en) * | 2019-05-22 | 2020-11-26 | 浙江欧洁科技股份有限公司 | Mouthwash for sterilization and disinfection of oral cavity, preparation method therefor and method for using same |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103462939A (en) * | 2013-09-16 | 2013-12-25 | 湖南省畜牧兽医研究所 | Povidone iodine film coating agent for treating mastitis of dairy cows and preparation method of povidone iodine film coating agent for treating mastitis of dairy cows |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103462939A (en) * | 2013-09-16 | 2013-12-25 | 湖南省畜牧兽医研究所 | Povidone iodine film coating agent for treating mastitis of dairy cows and preparation method of povidone iodine film coating agent for treating mastitis of dairy cows |
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| 周庆民: "奶牛乳头药浴涂膜剂膜材的筛选", 《黑龙江畜牧兽医》 * |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108079120A (en) * | 2017-12-06 | 2018-05-29 | 常州三伊化工有限公司 | A kind of cow teats disinfectant |
| CN108403671A (en) * | 2018-06-11 | 2018-08-17 | 佛山市南海东方澳龙制药有限公司 | Betagen Solution and preparation method thereof |
| CN108403671B (en) * | 2018-06-11 | 2021-04-27 | 佛山市南海东方澳龙制药有限公司 | Povidone-iodine solution and preparation method thereof |
| WO2020233371A1 (en) * | 2019-05-22 | 2020-11-26 | 浙江欧洁科技股份有限公司 | Mouthwash for sterilization and disinfection of oral cavity, preparation method therefor and method for using same |
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| CN106798749B (en) | 2020-03-10 |
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