CN106729954A - A kind of preparation method of the medical dressing containing sericin - Google Patents
A kind of preparation method of the medical dressing containing sericin Download PDFInfo
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- CN106729954A CN106729954A CN201611044904.XA CN201611044904A CN106729954A CN 106729954 A CN106729954 A CN 106729954A CN 201611044904 A CN201611044904 A CN 201611044904A CN 106729954 A CN106729954 A CN 106729954A
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- 108010013296 Sericins Proteins 0.000 title claims abstract description 16
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- 238000003756 stirring Methods 0.000 claims abstract description 26
- ROOXNKNUYICQNP-UHFFFAOYSA-N ammonium persulfate Chemical compound [NH4+].[NH4+].[O-]S(=O)(=O)OOS([O-])(=O)=O ROOXNKNUYICQNP-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000006185 dispersion Substances 0.000 claims abstract description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000007788 liquid Substances 0.000 claims abstract description 14
- 238000010792 warming Methods 0.000 claims abstract description 14
- 229910001870 ammonium persulfate Inorganic materials 0.000 claims abstract description 12
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims abstract description 7
- 229920002472 Starch Polymers 0.000 claims abstract description 7
- 239000003431 cross linking reagent Substances 0.000 claims abstract description 7
- 239000012467 final product Substances 0.000 claims abstract description 7
- 239000005457 ice water Substances 0.000 claims abstract description 7
- 238000009413 insulation Methods 0.000 claims abstract description 7
- 239000000787 lecithin Substances 0.000 claims abstract description 7
- 229940067606 lecithin Drugs 0.000 claims abstract description 7
- 235000010445 lecithin Nutrition 0.000 claims abstract description 7
- 239000000463 material Substances 0.000 claims abstract description 7
- 239000001509 sodium citrate Substances 0.000 claims abstract description 7
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims abstract description 7
- 235000019698 starch Nutrition 0.000 claims abstract description 7
- 239000008107 starch Substances 0.000 claims abstract description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 18
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 12
- 239000001569 carbon dioxide Substances 0.000 claims description 6
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 6
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims description 2
- 239000002861 polymer material Substances 0.000 claims description 2
- 229920003169 water-soluble polymer Polymers 0.000 claims description 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 claims 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 claims 1
- 235000011130 ammonium sulphate Nutrition 0.000 claims 1
- 206010052428 Wound Diseases 0.000 abstract description 8
- 208000027418 Wounds and injury Diseases 0.000 abstract description 8
- 208000025865 Ulcer Diseases 0.000 abstract description 3
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 3
- 230000008901 benefit Effects 0.000 abstract description 3
- 230000001684 chronic effect Effects 0.000 abstract description 3
- 230000035876 healing Effects 0.000 abstract description 3
- 208000004210 Pressure Ulcer Diseases 0.000 abstract description 2
- 208000003251 Pruritus Diseases 0.000 abstract description 2
- 230000008859 change Effects 0.000 abstract description 2
- 230000017423 tissue regeneration Effects 0.000 abstract description 2
- 231100000397 ulcer Toxicity 0.000 abstract description 2
- 230000029663 wound healing Effects 0.000 description 7
- CCJAYIGMMRQRAO-UHFFFAOYSA-N 2-[4-[(2-hydroxyphenyl)methylideneamino]butyliminomethyl]phenol Chemical compound OC1=CC=CC=C1C=NCCCCN=CC1=CC=CC=C1O CCJAYIGMMRQRAO-UHFFFAOYSA-N 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 230000008569 process Effects 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000001771 impaired effect Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 206010048038 Wound infection Diseases 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000003519 biomedical and dental material Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002431 foraging effect Effects 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 229940034586 silk sericin Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0028—Polypeptides; Proteins; Degradation products thereof
- A61L26/0047—Specific proteins or polypeptides not covered by groups A61L26/0033 - A61L26/0042
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention provides a kind of preparation method of the medical dressing containing sericin, during silk gum first added into water, N NMAs, sodium citrate, lecithin, low-molecular weight chitoglycan are added under stirring condition, dispersion obtains mixed liquor A；Take again during starch adds to water, water-soluble high-molecular material is added under stirring condition, disperse, regulation pH value is warming up to 50 100 DEG C of 5 30min of insulation to 7 13, is cooled to 30 50 DEG C, obtains mixed liquid B；During mixed liquor A finally added into mixed liquid B, crosslinking agent is added, be cooled under ice-water bath under 25 DEG C, stirring condition and add ammonium persulfate, be warming up to 40 65 DEG C of 2 6h of reaction, obtained final product.Gained of the invention dressing have the advantages that healing soon, dressing not bitterly, antibacterial, cost performance high, without pain and dressing change frequency it is few, can be used for tissue repair, ulcer, itch, bedsore, chronic wounds.
Description
Technical field
The invention belongs to medical dressing technical field, and in particular to a kind of preparation side of the medical dressing containing sericin
Method.
Background technology
Medical dressing in wound healing process, can substitute impaired skin and play temporarily as the covering of wound
The barrier action of when property, it is to avoid or the infection of control wound, there is provided be conducive to the environment of wound healing.Use suitable part
Antiseptic dressing can fully reduce the infection of wound, while promoting wound healing comprehensively.Medical dressing as wound covering
Thing, in wound healing process, can substitute impaired skin and play temporary barrier action, it is to avoid or control wound infection,
It is provided with the environment beneficial to wound healing.With increasing for aging population and chronic ulcerative wound, the market of medical dressing
Value also becomes more and more important.1962, British Winter proposed " wet wound healing is theoretical ", i.e., wound is in moistening
In the environment of it is faster than being healed under dry environment so that people have breakthrough progress to the understanding of wound healing process.
Silk gum（SilkSericin, SS）It is a kind of globular preteins, accounts for the 20~30% of silk gross weight, by 18 kinds of amino
Acid composition, in these amino acid, polar side chains account for 74.61%, therefore silk gum has good water solubility and water suction
Property.Research simultaneously also demonstrates silk gum to be had good hygroscopicity, biocompatibility, antibiotic property, inoxidizability and promotes thin
Born of the same parents' adhesion and the effect of propagation etc., are the desirable feedstocks for manufacturing biomedical material.
The content of the invention
The technical problem of solution：The purpose of the present invention overcomes the deficiencies in the prior art and provides a kind of containing sericin
The preparation method of medical dressing, gained dressing has that healing is fast, dressing not bitterly, antibacterial, cost performance high, without pain and dressing change frequency
Few advantage.
Technical scheme：A kind of preparation method of the medical dressing containing sericin, comprises the following steps：
Step 1, in parts by weight, silk gum 0.2-0.7 parts is added in water 10-20 parts, and N- methylols third are added under stirring condition
Acrylamide 0.1-0.3 parts, sodium citrate 0.05-0.08 parts, lecithin 0.01-0.03 parts, low-molecular weight chitoglycan 0.02-0.06
Part, dispersion obtains mixed liquor A；
Step 2, in parts by weight, takes starch 2-4 parts and adds in water 10-20 parts, and water soluble polymer material is added under stirring condition
0.8-1.5 parts of material, dispersion, regulation pH value is warming up to 50-100 DEG C of insulation 5-30min to 7-13, is cooled to 30-50 DEG C, obtains
Mixed liquid B；
Step 3, in parts by weight, during mixed liquor A added into mixed liquid B, adds crosslinking agent 0.5-1.2 parts, and ice-water bath declines
Temperature adds 0.1-0.5 parts of ammonium persulfate to 2-5 DEG C under stirring condition, be warming up to 40-65 DEG C of reaction 2-6h, obtains final product.
Further, dispersion condition is 300-500rpm, 20-30min in step 1.
Further, dispersion condition is 400-600rpm, 10-15min in step 2.
Further, pH is adjusted with 10-15wt.%NaOH solution in step 2.
Further, stirring condition is 200-300rpm in step 3.
Further, ammonium persulfate is added under carbon dioxide atmosphere in step 3.
Beneficial effect：Gained of the invention dressing has that healing is fast, dressing not bitterly, antibacterial, cost performance high, without pain and dressing
The few advantage of number of times, can be used for tissue repair, ulcer, itch, bedsore, chronic wounds.
Specific embodiment
Embodiment 1
A kind of preparation method of the medical dressing containing sericin, comprises the following steps：
Step 1, in parts by weight, during 0.2 part of silk gum added into 10 parts of water, N hydroxymethyl acrylamide is added under stirring condition
0.1 part, 0.05 part of sodium citrate, 0.01 part of lecithin, 0.02 part of low-molecular weight chitoglycan, dispersion, obtain mixed liquor A；
Step 2, in parts by weight, is taken during 2 parts of starch adds to 10 parts of water, and water-soluble high-molecular material 0.8 is added under stirring condition
Part, dispersion, regulation pH value is warming up to 50 DEG C of insulation 30min to 7, is cooled to 30 DEG C, obtains mixed liquid B；
Step 3, in parts by weight, during mixed liquor A added into mixed liquid B, adds 0.5 part of crosslinking agent, and 2 are cooled under ice-water bath
DEG C, 0.1 part of ammonium persulfate is added under stirring condition, 40 DEG C of reaction 6h are warming up to, obtain final product.
Wherein, dispersion condition is 300rpm, 30min in step 1；Dispersion condition is 400rpm, 15min in step 2；With
10wt.%NaOH solution adjusts pH；Stirring condition is 200rpm in step 3, and ammonium persulfate is added under carbon dioxide atmosphere
's.
Embodiment 2
A kind of preparation method of the medical dressing containing sericin, comprises the following steps：
Step 1, in parts by weight, during 0.4 part of silk gum added into 13 parts of water, N hydroxymethyl acrylamide is added under stirring condition
0.15 part, 0.06 part of sodium citrate, 0.02 part of lecithin, 0.04 part of low-molecular weight chitoglycan, dispersion, obtain mixed liquor A；
Step 2, in parts by weight, is taken during 3 parts of starch adds to 12 parts of water, and water-soluble high-molecular material 0.9 is added under stirring condition
Part, dispersion, regulation pH value is warming up to 70 DEG C of insulation 20min to 9, is cooled to 40 DEG C, obtains mixed liquid B；
Step 3, in parts by weight, during mixed liquor A added into mixed liquid B, adds 0.8 part of crosslinking agent, and 5 are cooled under ice-water bath
DEG C, 0.4 part of ammonium persulfate is added under stirring condition, 60 DEG C of reaction 4h are warming up to, obtain final product.
Wherein, dispersion condition is 400rpm, 20min in step 1；Dispersion condition is 500rpm, 10min in step 2；With
12wt.%NaOH solution adjusts pH；Stirring condition is 300rpm in step 3, and ammonium persulfate is added under carbon dioxide atmosphere
's.
Embodiment 3
A kind of preparation method of the medical dressing containing sericin, comprises the following steps：
Step 1, in parts by weight, during 0.6 part of silk gum added into 18 parts of water, N hydroxymethyl acrylamide is added under stirring condition
0.2 part, 0.07 part of sodium citrate, 0.02 part of lecithin, 0.05 part of low-molecular weight chitoglycan, dispersion, obtain mixed liquor A；
Step 2, in parts by weight, is taken during 3 parts of starch adds to 18 parts of water, and water-soluble high-molecular material 1.2 is added under stirring condition
Part, dispersion, regulation pH value is warming up to 80 DEG C of insulation 10min to 11, is cooled to 40 DEG C, obtains mixed liquid B；
Step 3, in parts by weight, during mixed liquor A added into mixed liquid B, adds 0.9 part of crosslinking agent, and 2 are cooled under ice-water bath
DEG C, 0.4 part of ammonium persulfate is added under stirring condition, 50 DEG C of reaction 3h are warming up to, obtain final product.
Wherein, dispersion condition is 400rpm, 30min in step 1；Dispersion condition is 600rpm, 15min in step 2；With
15wt.%NaOH solution adjusts pH；Stirring condition is 300rpm in step 3, and ammonium persulfate is added under carbon dioxide atmosphere
's.
Embodiment 4
A kind of preparation method of the medical dressing containing sericin, comprises the following steps：
Step 1, in parts by weight, during 0.7 part of silk gum added into 20 parts of water, N hydroxymethyl acrylamide is added under stirring condition
0.3 part, 0.08 part of sodium citrate, 0.03 part of lecithin, 0.06 part of low-molecular weight chitoglycan, dispersion, obtain mixed liquor A；
Step 2, in parts by weight, is taken during 4 parts of starch adds to 20 parts of water, and water-soluble high-molecular material 1.5 is added under stirring condition
Part, dispersion, regulation pH value is warming up to 100 DEG C of insulation 5min to 13, is cooled to 50 DEG C, obtains mixed liquid B；
Step 3, in parts by weight, during mixed liquor A added into mixed liquid B, adds 1.2 parts of crosslinking agent, and 5 are cooled under ice-water bath
DEG C, 0.5 part of ammonium persulfate is added under stirring condition, 65 DEG C of reaction 2h are warming up to, obtain final product.
Wherein, dispersion condition is 500rpm, 20min in step 1；Dispersion condition is 600rpm, 10min in step 2；With
15wt.%NaOH solution adjusts pH；Stirring condition is 300rpm in step 3, and ammonium persulfate is added under carbon dioxide atmosphere
's.
Obtained dressing is placed in 75% ethanol, sterilize 40min, is rinsed 3 times with aseptic phosphate buffer, then with 37 DEG C
PBS constant temperature immersion 12h after move to 24 orifice plates, the inhibitory action of bacterial growth is by MK3 ELIASAs (Thermo, USA) inspection
The OD value OD630 for surveying bacterium in nutrient solution is 0.894, and blank OD630 is 1.023.
Claims (6)
1. a kind of preparation method of the medical dressing containing sericin, it is characterised in that：Comprise the following steps：
Step 1, in parts by weight, silk gum 0.2-0.7 parts is added in water 10-20 parts, and N- methylols third are added under stirring condition
Acrylamide 0.1-0.3 parts, sodium citrate 0.05-0.08 parts, lecithin 0.01-0.03 parts, low-molecular weight chitoglycan 0.02-0.06
Part, dispersion obtains mixed liquor A；
Step 2, in parts by weight, takes starch 2-4 parts and adds in water 10-20 parts, and water soluble polymer material is added under stirring condition
0.8-1.5 parts of material, dispersion, regulation pH value is warming up to 50-100 DEG C of insulation 5-30min to 7-13, is cooled to 30-50 DEG C, obtains
Mixed liquid B；
Step 3, in parts by weight, during mixed liquor A added into mixed liquid B, adds crosslinking agent 0.5-1.2 parts, and ice-water bath declines
Temperature adds 0.1-0.5 parts of ammonium persulfate to 2-5 DEG C under stirring condition, be warming up to 40-65 DEG C of reaction 2-6h, obtains final product.
2. the preparation method of the medical dressing containing sericin according to claim 1, it is characterised in that：Divide in step 1
The condition of dissipating is 300-500rpm, 20-30min.
3. the preparation method of the medical dressing containing sericin according to claim 1, it is characterised in that：Divide in step 2
The condition of dissipating is 400-600rpm, 10-15min.
4. the preparation method of the medical dressing containing sericin according to claim 1, it is characterised in that：Used in step 2
10-15wt.%NaOH solution adjusts pH.
5. the preparation method of the medical dressing containing sericin according to claim 1, it is characterised in that：Stirred in step 3
Condition is mixed for 200-300rpm.
6. the preparation method of the medical dressing containing sericin according to claim 1, it is characterised in that：Mistake in step 3
Ammonium sulfate is added under carbon dioxide atmosphere.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611044904.XA CN106729954A (en) | 2016-11-24 | 2016-11-24 | A kind of preparation method of the medical dressing containing sericin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611044904.XA CN106729954A (en) | 2016-11-24 | 2016-11-24 | A kind of preparation method of the medical dressing containing sericin |
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| Publication Number | Publication Date |
|---|---|
| CN106729954A true CN106729954A (en) | 2017-05-31 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611044904.XA Pending CN106729954A (en) | 2016-11-24 | 2016-11-24 | A kind of preparation method of the medical dressing containing sericin |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107233610A (en) * | 2017-07-12 | 2017-10-10 | 江苏科技大学 | A kind of sericin wound dressing and its preparation method and application |
| CN107693842A (en) * | 2017-12-05 | 2018-02-16 | 湖北美尔丽生物科技有限公司 | A kind of medical resistance to hydrogel and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103833916A (en) * | 2012-11-23 | 2014-06-04 | 石学香 | Preparation process of medical starch acrylate composite hydrogel |
| CN104368033A (en) * | 2014-10-23 | 2015-02-25 | 天津工业大学 | Highly-bacteriostatic fast-healing fiber, membrane and massive sericin based dressing and preparation method thereof |
| CN105497970A (en) * | 2015-12-25 | 2016-04-20 | 重庆理工大学 | Medical dressing with sticking function and capable of rapidly promoting healing |
| CN105536058A (en) * | 2016-01-22 | 2016-05-04 | 青岛中腾生物技术有限公司 | Medical starch sponge and preparation method and application thereof |
| CN105985529A (en) * | 2015-03-05 | 2016-10-05 | 华中科技大学同济医学院附属协和医院 | Sericin-alginate compounded hydrogel and preparation method thereof |
-
2016
- 2016-11-24 CN CN201611044904.XA patent/CN106729954A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103833916A (en) * | 2012-11-23 | 2014-06-04 | 石学香 | Preparation process of medical starch acrylate composite hydrogel |
| CN104368033A (en) * | 2014-10-23 | 2015-02-25 | 天津工业大学 | Highly-bacteriostatic fast-healing fiber, membrane and massive sericin based dressing and preparation method thereof |
| CN105985529A (en) * | 2015-03-05 | 2016-10-05 | 华中科技大学同济医学院附属协和医院 | Sericin-alginate compounded hydrogel and preparation method thereof |
| CN105497970A (en) * | 2015-12-25 | 2016-04-20 | 重庆理工大学 | Medical dressing with sticking function and capable of rapidly promoting healing |
| CN105536058A (en) * | 2016-01-22 | 2016-05-04 | 青岛中腾生物技术有限公司 | Medical starch sponge and preparation method and application thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107233610A (en) * | 2017-07-12 | 2017-10-10 | 江苏科技大学 | A kind of sericin wound dressing and its preparation method and application |
| CN107693842A (en) * | 2017-12-05 | 2018-02-16 | 湖北美尔丽生物科技有限公司 | A kind of medical resistance to hydrogel and preparation method thereof |
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Application publication date: 20170531 |